Synonym: CELE_K09H11.7, CELE_K09H11.7
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_PGP_pd | Subfamily PGP | 17-296 | 1.3e-97 | 317.4 | In-house | 1-267 (279) | alignment | ||
Range on Protein: 17-296
Range on HMM: 1-267/279.0
TFVFDADGVLWTGDIPIPGAAEWINTLLdDPEKSVFITTNNSTKTLEQYMKKVKKMRFGRLGRENLLSPTIVLCDYFKQnsDKFENQyIYLIGVENLKKS
|..||.|||||.|. .||||||..|.| . .|.|...||||||. |...||.||..| .. .|..||......||.|| .|||.. .|..| |.||..
tvlfDcDGVlWlgetaipgaaealnaLk.klgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq..kkfekk.vyvlgeeglkee
LEEGgGVKCFGTGPDHKDNYTDGDFINEVDVKSkIPKAVVVSFDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFPGPVpGMILPETGPWSAAIQNVSGR
|.| |....||||..... .|.||..|..... .||||..|...||.||.||||.| .| |.||..|||...|.. ....|..|.. |||...|||
Lkea.giellgtgpeklkdeldedfveelkldk.dvgAVvvgvdeklsyakllkAanyLrepevlflatneDallplkk.evvipgaGslvaaieaasgr
KPdIVFGKPHEQLANFLKSRVQAgkfNSERTVMFGDRLDTDMMFGKNNGFTTVWMQTGVNTLLDIELARKNGesTKIPDF
|| .|.|||.|.|...|... . . |||.|.||||.||..||||.|..|.....||..| |.| ..|.. ...||.
kp.lvlGKPnelllelllekeei...dpertlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkee..klvPdy
|
|||||||||
Chronophin_1 | 16-286 | 2.6e-48 | 155.7 | In-house | 2-241 (261) | alignment | |||
Range on Protein: 16-286
Range on HMM: 2-241/261.0
DTFVFDADGVLWTGDIPIPGAAEWINTLlDDPEKSVFITTNNSTKTLEQYMKKVKKMRFGRLGRENLLSPTIVLCDYFKQnsdKFENQYIYLIGVENLKK
... .| ||||. |. .||||| |..| . .|.|...||||..| |.. ...|.. . . |...| .. . .| . . .|..| | |.|
qlvLlDldGVlikgeeavpgAaelieal.kqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq...qaakakvyvlGeeglrk
SLEEGGGVKCFGTGPdhkdnytdgdfinevdvkskIPKAVVVSFDSHFSYPKLMKAANFLADPlVEFLVCNEDSTFPGPVpGmILPETGPWSAAIQNVSG
.|.| | . .. . ..|||| .| ..|. || .|.. . |. |.. |.| |.| . | |.| || ||.. ||
elreaGlrlvdeped....................rveaVvvGydeelsfeklaeaialirdg.alfvatnrDptvPlee.G.iaPgtGslaaaveaAsg
RKPDIVfGKPHEQLANFLKSRVQAgkfNSERTVMFGDRLDTDMMFGKNNGFTTVWMQTGVNTLLDIELARK
|.| .| |||. . . ....| ..|.||| |||||||. .|.. |..|. . ||| .| ... ..|
replvv.GKPepvmfeealekiga...dpeetvmvGDRldTDilagaraglstllvltGvseleeaqaykk
|
|||||||||
Chronophin_2 | 18-285 | 3.7e-45 | 145.4 | In-house | 3-254 (282) | alignment | |||
Range on Protein: 18-285
Range on HMM: 3-254/282.0
FVFDADGVLWTGDIPIPGAAEWINTLLDDpEKSVFITTNNSTKTLEQYMKKVKKMRFGRLGRENLLSPTIVLCDYFKQNSDKfeNQYIYLIGVENLKKSL
.|| |||.| |. ..||.| ...| | |.. |||||.. |.|..| .. | . |...| .. |... .| . .. || | |.| |
vlfdcdgviwngekavagapevvsrlara.gknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadv..rgkvfviggeglrkel
EEGgGVKCFGTgPDHKDnytdgDFINEVDVKSKIpKAVVVSFDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFPGpVPGMILPETGPWSAAIQNVSGRK
.| ||.. . .|... | .. .. .. .||.| .| .... || ||. .| |. .| ..| | | |.| .| .||.. ||||
rea.gvpvved.adeqe.....asiydcaldpdv.ravlvgydekltflklakacaylrdadclllatdrdpwhpl.sdgritpgsgsltaaletasgrk
PdIVFGKPHEQLANFLKSRVQagkFNSERTVMFGDRLDTDMMFGKNNGFTTVWMQTGVNTLLDIELAR
.| ||| . . . . | . . |..| ||||.||..||.| |..|| ||| .| . . .
a.tvigkpsrfmfecissqfs...vdparslmigdrletdilfgsncglstvltltgvssleeaqeys
|
|||||||||
Hydrolase_6 | Haloacid dehalogenase-like hydrolase | 18-121 | 1.2e-23 | 74.4 | Pfam-A | 1-99 (101) | alignment | ||
Range on Protein: 18-121
Range on HMM: 1-99/101.0
FVFDADGVLWTGDIPIPGAAEWINTLLDDpEKSVFITTNNSTKTLEQYMKKVKKMRFGrLGRENLLSPTIVLCDYFKQNSDkfeNQYIYLIGVENLKKSL
|.|| ||||| || .|||||| ...| . .| |.. ||||.|. |.|.||..|. . . |..... .. .|.|.. .. ...|| |.|.. |
flfDvdGvLwrgdkaipgaaealkalraa.gkpvvllTNnsskseeeyakkleklgvd.vteeqvvtsataaaeylkkrka...dkkvlvigeeglreel
EEGG
.| |
keaG
|
|||||||||
Hydrolase | haloacid dehalogenase-like hydrolase | 16-264 | 1.9e-11 | 36.1 | Pfam-A | 2-214 (215) | alignment | ||
Range on Protein: 16-264
Range on HMM: 2-214/215.0
DTFVFDADGVLWTGDIPI--PGAAEWINTLLDD--------PEKSVFITTNNSTK-----------------------TLEQYMKKVKKMRF-GRLGREN
.|.||| .|.|..| .. .|........ . .. |.....|||. . ...|... . . ..|. ..
ktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrggltgfatfigrgvsgkvdgivlgnpewmtalglrviapdlvaae
L-LSPTIVLCDYfkqnsdkfenqyIyligvenlkksleegggvkcfgtgpdhkdnytdgdfinevdvkskipkAVVVSFDSHFS---YPKLMKAANFLAD
...|. . . .... . .|. .|....| . | .
gqskgrtvvvva............v................................................qaralgviafadpvkpeaaeavasLke
PLV-EFLVC-------NEDSTFPGPvpgmilpeTGPWSAAIQNvsgrkpdivfGKPHEQLANFLKSRVQAgkfNSERTVMFGDRLdTDMMFGKNN
. .|. . . ...| .. . | |||...| . . . | . ....|.||.. .|. ....
aGievvlltgdnpetaeaiakqagi........edslvfaevv..........gkPepklfvaaieeLqi...dpgevamvGDgv.nDapalaaA
|
|||||||||
Hydrolase_like | HAD-hyrolase-like | 222-280 | 5.9e-11 | 33.5 | Pfam-A | 2-57 (75) | alignment | ||
Range on Protein: 222-280
Range on HMM: 2-57/75.0
FGKPHEQLANFLKSRVqagKFNSERTVMFGDRLDTDMMFGKNNGFTTVWMQTGVNTLLD
|||.... . . . .....|| ||.|.||. ...| | ... ||| . |
lgKPnpgmydkalevl...gappsevvmiGDslatDieaAnnaGirsilVltGvsreed
|
|||||||||
subfamily_LHPP_pd | Subfamily LHPP | 143-275 | 2.1e-10 | 32.0 | In-house | 94-220 (227) | alignment | ||
Range on Protein: 143-275
Range on HMM: 94-220/227.0
NEVDvKSKiPKAVVVS-FDSHFSYPKLMKAANFLADPLVEFLVCNEDSTFPGPVPGMILpETGPWSAAIQNVSGRKPDIVfGKPHeqlANFLKSRVQAGK
...| .| |.|||.. . .|.| .| .| . |.. . |.. . . . |..| . |.. .|.. | | .| |||. |.| .. ... .
edid.tdk.pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlal.gpGafvkaleyatgvkaevv.GKPs...alffekaleelg
FNSERTVMFGDRLDTDMMFGKNNGFTTVWMQTGV
. |. || || . |. . |. .| .||.
vdpeeavmiGDdvedDveGAlkaGlrgvlVktGk
|
|||||||||
subfamily_LHPP_pd | Subfamily LHPP | 18-98 | 3.5e-08 | 24.7 | In-house | 1-79 (227) | alignment | ||
Range on Protein: 18-98
Range on HMM: 1-79/227.0
FVFDADGVLWTGDIPIPGAAEWINTLLDdPEKSVFITTNNSTKTLEQYMKKVKKMRFGrLGRENLLSPTIVLCDYFKQNSD
.. | |||...| .||||.| .. | . .. | . ||.. .. .. ... ... |. . |...... . ... ....
vllDlsGvlhnedaaipgavealkrLrq.agvkvrfvtNttkeskralverLirlgfd.veeeeiftsleaarqllrerkl
|
|||||||||
PGP_phosphatase | Mitochondrial PGP phosphatase | 226-275 | 3.6e-07 | 19.8 | Pfam-A | 120-167 (168) | alignment | ||
Range on Protein: 226-275
Range on HMM: 120-167/168.0
HEQLANFLKSRVQagKFNSERTVMFGDRLDTDMMFGKNNGFTTVWMQTGV
.|.. ...|.. . ... .. |||| ||..... .| . ||.. ||
aeevleyfkekkv..vtkadeiavvgDRllTdvlmanmmGslsvwlregv
|