Gene C46A5.1 in Caenorhabditis elegans

Synonym: CELE_C46A5.1, C46A5.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf16
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP037_AA protein Get Run
CeleP037_AA_202-471 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 197-485 9.9e-187 613.7 In-house 1-294 (303) alignment 
Range on Protein: 197-485
Range on HMM: 1-294/303.0
ISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSSYIHANWVDLNSSKKAILTQLPLSHTASDFW
||.||..||||.|..||..||||||||||||..||||..|||.||.||||||||||||.|||.|||.|||||||....|.||||||||||||||||.|||
iseekkqkwkllakrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfw

QMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSD-----VKQIWQ
||||.||.|||||..||.|..|.||.||||.||||||||.|.|||||||.||||.||.|||||||||.||.|.||||||.|||.|||||     ||||||
qmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq

VQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEEQEN
.||.||||.|..|.||||.||||||||||||||||.|||.||.||..|||||||||||||.|||||||||||||.|||||.||| |  . .. |
lqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpn
0040438 (Phosphotyrosine protein) phosphatases II 203-471 3.2e-61 202.7 In-house 3-277 (317) alignment 
Range on Protein: 203-471
Range on HMM: 3-277/317.0
TKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNS-SKKAILTQLPLSHTASDF
....|. .  || |...  .|||..  . ....|  ... |.||||..|... |||||||..      |.||.|..||  . ..| |.|| ||..|  ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQ
|.|. .|...... ...  |...      .|. ...|...| .... ....    .|..| .| |.  .. .. .....||..||....|.. .....  
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

SYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
...|..   .|.| . ... |.||.|||.. ..... |. |.  ... .... .|. | ..||...|.  .|....|...
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk
0039614 (Phosphotyrosine protein) phosphatases II 196-471 6.2e-58 191.9 In-house 10-290 (297) alignment 
Range on Protein: 196-471
Range on HMM: 10-290/297.0
KISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPhISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLNS--SKKAILTQL
. ....|. . |. . . ... ..  .|||..  . |. .|  ... |.||||..|... |||||||        ||.||.|..||  .  ..| |.|| 
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQDflKFEDRFIRVGEFKQvelGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDV
||..|  |||.|. .|...... ...  | ..    . .|....  ...| .... ....    .|... .|.|.|. .  ......| .||....|...
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

KQIWQVQSYLRKYT----DGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
... ..  ..|..     .|.| . ... |.||.|||..  ...  |. |   ... .... .|. | ..||..||.  .| ...|...
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
0036941 (Phosphotyrosine protein) phosphatases II 229-474 1e-57 191.1 In-house 25-281 (297) alignment 
Range on Protein: 229-474
Range on HMM: 25-281/297.0
GYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVF
 .|....|  ... |..|||. |... ||.||||.|..  ||.|..||. . ..| |.|| ||..|  |||.|. .|...... . .. | ..    . .
llllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqyw

PQN-QDFLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSN--GTYKTFIHVHHYKNWPHGSIPSDVKQ----IWQVQSYLRKYTDGHPPVYMSMSGCGRAGT
| . ...|...| .... ....| | ... | .| |..  . .. .....||..||. ..|.....    |..|...|.....|.| . ... |.||.||
pleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

FALFETAHMSLHN--EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNG
|.. ..... |..  ... .......  .|. | ..||.|.|.  .| ...|... . 
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0043336 (Phosphotyrosine protein) phosphatases II 205-469 2.5e-56 186.5 In-house 7-276 (278) alignment 
Range on Protein: 205-469
Range on HMM: 7-276/278.0
WKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQ
.    .| |...  .  .|||..  . ....|  ... |.||||..|... |||||||..      |.||.|..||. . ..| |.|| ||..|  |||.
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

MIIDQKIKCVLLIMTDGEFNKFGGNSVFPqnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYkTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLR
|. ........ .... |... .    .|  ...|...| .... .... .  . ..|.|    .| .  .....||..||....|........   ..|
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavr

KY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
..  ....| . ... |.||.|||.. ..... |..|.  ... .... .|. | ..||..||.  .| ...|.
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 243-468 7.6e-56 184.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 243-468
Range on HMM: 1-235/235.0
NMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
|..|||. |....|..||||    ..| ||.||.|..  ..|| |.|| ||..| .|||.|....|.|.. .. .. | ..   .  .| .....|...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RFIRVGeFKQVELGKGWNLKVLSVSNGTYKT---FIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAHMSLHN
 ....   |. |  |...|..|.... . ..    ....||.|||. ..|...|.....   ..|..  . .| | ... |.||.|||.. ... ..|..
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|.  ..........|. | ..||.|.|. ..| .|.|
eee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 243-468 7.6e-56 184.5 In-house 1-235 (235) alignment 
Range on Protein: 243-468
Range on HMM: 1-235/235.0
NMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
|..|||. |....|..||||    ..| ||.||.|..  ..|| |.|| ||..| .|||.|....|.|.. .. .. | ..   .  .| .....|...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RFIRVGeFKQVELGKGWNLKVLSVSNGTYKT---FIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAHMSLHN
 ....   |. |  |...|..|.... . ..    ....||.|||. ..|...|.....   ..|..  . .| | ... |.||.|||.. ... ..|..
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|.  ..........|. | ..||.|.|. ..| .|.|
eee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0050432 (Phosphotyrosine protein) phosphatases II 202-470 1.6e-55 184.0 In-house 9-299 (308) alignment 
Range on Protein: 202-470
Range on HMM: 9-299/308.0
LTKWKLVAQETLKDDANIAVNEFEK------------------VSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT-DSSYIHANWVDL---NSSK
|... .. ...|. . .. | .. |                   | . .. .|   .. |.||||..|... |||||||  .|.||.|..||.   ....
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklpr

KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN--QDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN--GTYKTFIHVHHYK
| |.|| ||..|  |||.|. .|.....  ...  | ..      .| .  ...|.... .... . ..    ... . .| ..|  . .  .... ||.
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhyt

NWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|||....|........   ..||. .|.| | ... |.||.|||.. ....  |. |   ... ...  .|  | ..||...|.  .| ...|..
nWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleyl
DSPc_SM00195 224-469 2.8e-55 182.9 In-house 6-261 (263) alignment 
Range on Protein: 224-469
Range on HMM: 6-261/263.0
FEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||.  .  | ....... .|..|||. .....||.||||..      |.||.||..... ..|| |.|| ||..| .|||.|....|.|... .. . |
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeee

FNKFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVElgKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--GHPPVYMSM
 .|   .. .|.. ..  .|..  . . | ....  . ..|..|.... .   ........|||||. ..|.. |.. .. ....| ..   .| | .. 
ngkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

SGCGRAGTFALFETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
 |.||.|||.. ...  .|..|.  ... ......|. | ..||.| |....|. |.| 
aGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 224-469 2.8e-55 182.9 In-house 6-261 (263) alignment 
Range on Protein: 224-469
Range on HMM: 6-261/263.0
FEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||.  .  | ....... .|..|||. .....||.||||..      |.||.||..... ..|| |.|| ||..| .|||.|....|.|... .. . |
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeee

FNKFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVElgKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--GHPPVYMSM
 .|   .. .|.. ..  .|..  . . | ....  . ..|..|.... .   ........|||||. ..|.. |.. .. ....| ..   .| | .. 
ngkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

SGCGRAGTFALFETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
 |.||.|||.. ...  .|..|.  ... ......|. | ..||.| |....|. |.| 
aGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
0045450 (Phosphotyrosine protein) phosphatases II 200-471 4.7e-55 182.8 In-house 9-305 (307) alignment 
Range on Protein: 200-471
Range on HMM: 9-305/307.0
EKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPP---HISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLN---------SSKK
....|. |  ...|.|. ..   ||||.  . ..   ..|  ... |.||||..|... ||.||||        ||.||.|..|...         ...|
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS---NGTYKTFIHVHHYKNW
 |.|| ||..|  |||.|. .|...... .... |...      .|.....| ... .... ....    .|. . .| |.      .  .....||..|
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgw

PHGSIPSDVKQIWQ----VQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPS--LNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
|....|...... .    |...|.....|.| . ... |.||.|||..  ..   |..|.    ... .... .|. | ..|||..|.  .| ...|..|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0046845 (Phosphotyrosine protein) phosphatases II 223-470 1.6e-54 180.6 In-house 5-274 (284) alignment 
Range on Protein: 223-470
Range on HMM: 5-274/284.0
EFEKVSGYLPP---HISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDL------NSSKKAILTQLPLSHTASDFWQMIIDQKIKC
|||..  . ..   ..|  ... |..|||..|... |||||||        ||.||.|..||       ...|| |.|| ||..|  |||.|. .|....
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN---GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--
.  ...  |...      .|.....|...| .... . ..    ... . .|...|   . .  .....||..||. ..|........   ..|.. .  
IVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

--GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
  |.| | ... |.||.|||.. ....  |..|..   ... ...  .|. | ..||.|.|.  || ...|..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 205-470 1.7e-54 180.6 In-house 10-286 (288) alignment 
Range on Protein: 205-470
Range on HMM: 10-286/288.0
WKLVAQETLKDDANIAVNEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFW
.  . ...|... ..  .|||..  .| ....|  ... |..|||..|... |||||||.      .|.||.|...|. |...| |.|| ||..| .|||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

QMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS------NGTYKTFIHVHHYKNWPHGSIPSDVKQIW
.|. .|.....  ...  |...      .|. ...|...| ...  . ..    ... . .| |.       . .. .....||.|||. ..|.......
rmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

QVQSYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
.   ..||.   .|.| | ... |.||.|||.. ..... |..|   ... . .. .|. | ..||...|.  || ...|..
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 220-470 1.9e-51 170.5 In-house 14-272 (273) alignment 
Range on Protein: 220-470
Range on HMM: 14-272/273.0
AVNEFEKVSGYLPPHI-SKNHFVSNMDKNRFVDVICMDHSRVKL--TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
   |||..  . |..  |   .. |.||||. |... |||||||   .|.||.|..||. |...| |.|| ||..|  |||.|. .|.....  .... |
lleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

FNKFGGNSVFPQNQD--FLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN--GTYKTFIHVHHYKNWPHGSIPSDVKQ----IWQVQSYLRKYTDGHPPVY
 ..      .|....  .|.... .... . ..    ... . .| ..|    .. .....||..||  ..|.....    |..|...|... ...| | 
lgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV

MSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
... |.||.|||.. ....  |. |   ... ...  .|. | ..||...|.  .| ...|..
HCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045098 (Phosphotyrosine protein) phosphatases II 222-471 7.9e-51 168.4 In-house 12-273 (278) alignment 
Range on Protein: 222-471
Range on HMM: 12-273/278.0
NEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKltdsSYIHANWVDLNsSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGG
  ..... . |  |. . ...|.||||..|... ||||||     ||.|...|   .|| |.|| || .|..|||.|. ...|.... ...  | ..   
efefllllgipseitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

NSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSV---SNGTYKTFIHVHHYKNWPHGSIPSDV--KQIWQVQSYLRKYT---------------D
   .|  ...| ..| .... ......    . |.|  .    .. .. .....||..|| ...||.   |.....  ..|..                .
aqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GHPPVYMSMSGCGRAGTFALFETAHMSLhneQPSLNMVKCLENVRNGRLH-SVQNLSQFSVVYTLIAEHVL
|.| .   . |.||.||...  .    |   .. ... .... .|. | . .||||.|.  .| ...|..|
ggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 236-471 9.5e-49 161.6 In-house 4-247 (249) alignment 
Range on Protein: 236-471
Range on HMM: 4-247/249.0
SKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQn
|  ... |.||||..|... |||||||..      |.||.|...|.  .... |.|| ||..| .|||.|. ...|.... .... |... .    .|. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

QDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT----DGHPPVYMSMSGCGRAGTFALF
...|...| .... ....    ... . .| ..      .  ... .| .||. ..|...... .   ..||.     .|.| . ... |.||.|||.. 
ggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

ETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
 .... |. |.  ...  ... .|. | ..|||..|.  .| ...|..|
ylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallelll
0037934 (Phosphotyrosine protein) phosphatases II 239-468 1.5e-48 160.9 In-house 6-240 (243) alignment 
Range on Protein: 239-468
Range on HMM: 6-240/243.0
HFVSNMDKNRFVDVICMDHSRVKLTDSSYIHANWVDLNssKKAILTQLPLSHTASD----FWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPqnQDFlKF
... |..|||. |....||||||| .|.||.||...    .. |.||.||..|  |    ||.|. ...|.... .... | ....    .|  ...  .
llpenlsknrysdilpydhsrvklegsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.ty

EDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK----------YTDGHPPVYMSMSGCGRAGTFALFET
.| .... .... .  . ..|..  .. . .. ... .|| .||....|........  ...|.          . .|.| . . . |.||.||...  .
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

AHMSLhneqpSLNMVKCLENVRNGRLH-SVQNLSQFSVVYTLIAE
 .. |     .... .... .|. | . .||..||.  .| ...|
mllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 239-468 1.7e-48 160.5 In-house 5-241 (245) alignment 
Range on Protein: 239-468
Range on HMM: 5-241/245.0
HFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDF
 .. |.||||..|... ||.||||.      ||.||.|..||.   ..| |.|| ||..|  |||.|. ...|.... .... |... .    .|. ...
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges

LKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK---YTDGHPPVYMSMSGCGRAGTFALFETAH
|...| .... ....    ... . .|.|.     .. .....|| .||....|......... ...||    ....| . ... |.||.|||..  ...
ltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

MSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
. |. |.  ... .... .|. | ..||..||.  .| ...|
eqlekel.gvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_PTPN12_pd Subfamily PTPN12 242-470 1.5e-36 120.8 In-house 39-277 (290) alignment 
Range on Protein: 242-470
Range on HMM: 39-277/290.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF-LK
.|. |||. |..  |.|||.|.      .|.|| ||..   ..|.. | .| ||..| .|||.||...... |...    | .|.  .  .|....  |.
envkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele

FEDrfIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD-GHPPVYMSM-SGCGRAGTFALFETAHMSLHN
|..  ..|   ..  . ... .. | | .   .  ..  ||..||   .|| .|.. .. . .|.. .  . |. .   .|.||.||    . ... |..
fge..fevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka

EQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|.   .|.. . . ..|. |   ||   |...||  .|| |
ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN1_pd Subfamily PTPN1 236-468 1.3e-32 107.7 In-house 25-269 (290) alignment 
Range on Protein: 236-468
Range on HMM: 25-269/290.0
SKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD--
.. .. .| ..||. ||   ||||.||   |  || |. |.|.   .. |||| ||..|.. ||||. .|| |.|...    | ..    . .||...  
reaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

FLKFEDRFIRVgEFKQVELGKGWNLKVLSVSNG-TYK-TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK----YTDGHPPVYMSMSGCGRAGTFALFET
 |..||  ..| .. . |  . . ...| . |  | .   |  .||  ||  ..|.   .  .    .|.     .|  |.|    .| ||.|||.| .|
ellledtklkv.kliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

AHMSLHNEQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
  . .....   |... | | ..|. ||  .|   |.   |. | |
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN13_pd Subfamily PTPN13 240-467 1.7e-32 107.8 In-house 34-266 (273) alignment 
Range on Protein: 240-467
Range on HMM: 34-266/273.0
FVSNMDKNRFVDVICMDHSRVKLTDSS-YIHANWVDLNSSK---KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKF
  .|.||||. .|. .|..|||| |.. || |... ..  |   ..|..| || .|..|||||. .|| . . .. .. | .|   .  .|....  || 
kkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

EDRfIRVGEFKQVELgKGWNLKVLSVSNGTYKTFIHVHH--YKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMS-MSGCGRAGTFALFETAhMSLHN
..| ..|   |...| .|.... | |..   .  ..| |  . .||  ..||  ... |. ...|.  . . |. .   .| ||.||.   ... . | .
snr.levellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv.lglie

EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
 . .... . ....|. |   ||   |.  ||  | 
rdkefdvkeivrklreqrqgvvqtkdqyifvykail
subfamily_PTPRD_pd Subfamily PTPRD 221-471 2.9e-32 107.1 In-house 26-282 (564) alignment 
Range on Protein: 221-471
Range on HMM: 26-282/564.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
 .|..|..     .... .   |  |||. ...  |||||.|       .| || |...|   ..|  | || ||..| .|||.|. .|..... ..   
eeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkl

GEFNKFGGNSVFPQNQdFLKFEDRFIRVGEFKQVELGKGWNLKVlSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMS
 | .|   .. .|...   ....  . . | ....     ..|. . ..   .  ..  |. .||.  .|   ... .. .  |...  | .| |    .
eEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa

GCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
| || |||   .     ...|.  ... ......|. | . ||. .|.. ... |.| . 
GVGRTGtfividamlerikeek.tvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_PTPN3_pd Subfamily PTPN3 235-466 3.2e-32 106.6 In-house 33-271 (280) alignment 
Range on Protein: 235-466
Range on HMM: 33-271/280.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNSSK-----KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
||. .   |..|||. |..  |. ||||..|.  || ||.|....       . | || ||..||.|||||. .||.. .... |  |  .      .|.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

NQDFLKFEDRFIRVGEFkqvELGKGWNLKVLSVSNGTY--KTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSMSGCGRAGTFALFE
..| |.. .  ... .    .  | . |. | ... .   .  |.   | .||  ..|.| ... .. . .||.  |  .| |    .| ||.| . |.|
tedeleygefsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

TAHMsLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
|| . | ... ...... . ..|. |   ||. ||.  |   |
tala.lieaaepvypldivrtmrdqramlvqtasqykfvCeai
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 241-468 1e-31 105.1 In-house 39-274 (281) alignment 
Range on Protein: 241-468
Range on HMM: 39-274/281.0
VSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLK
  |. |||.....  |..|||.      ... || ||.|. ... |. | || |. ..  .||||...||.. . ..  . | .|      .|...  ||
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselk

FEDRFIRVGEFKQVELGKGWNLKVlSVSNGTYKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG---HPPVYMSMSGCGRAGTFALFETAHMSLH
. |  ..  . .. .     ..|. . ..|  .. ..  .|..||   .|.. |.. . .. ..|.|.    .| |    .| ||.||.  ....  ...
ygdvtvkstaeeekatyierkfkl.eresgetre.veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave

NEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
.|...|..   ....|. |   || . |.. ||  . .
aeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 222-478 1.3e-31 104.6 In-house 14-278 (285) alignment 
Range on Protein: 222-478
Range on HMM: 14-278/285.0
NEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL--TDSSYIHANWVDLNSSKK--AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFN
   .|. ||.||  .   . .| | ||. || |.. .|| |   |  ||||.|. .    .   | || ||  | ||||.|| ..||  ||.. |  |  
lhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg

KFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVEL-GKGWN-LKVLSVSNGTYKTFIHVH-HYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSM-SG
       .|..  . .||    | . | |.  . |  .| | |.   . . . .   | .   ||    | | . . ..  ...|      |. .   .|
vekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsag

CGRAGTFALFETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKK
 ||. ||   . | . .  |.| ..|.  . ..|  |...||.  || ..| .. |...|.|. ..
vgrtatfvgidyatirim.enpniemldivremramrfqavqshmqflflyvvlmeyfigegvver
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 217-470 1.7e-31 103.8 In-house 25-285 (302) alignment 
Range on Protein: 217-470
Range on HMM: 25-285/302.0
ANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLN-SSKKAILTQLPLSHTA---SDFWQMIIDQKIKCVLLI
.    .||.|..    .  . . | .|..||.  || ..|. .|||.    ||..|  |..   ... ||.||| . ..    .||.|. ..||. | ..
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

MTDGEFNKfGGNSVFP-QNQDFLKFEDRFIRVGEFKQVELGK-GWNLKVLSvsNGT-YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSY--LRKYTDGHPP
. . | .|   . .|| . .|...... |. .   ...|  |  . . ||   .|     .. | . .||.. ..|  . .. .       .|    .. 
vgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlP..egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadent

VYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| .|. |.||||.|    .|  .|...    |.   ....|. | ..|..|.|.  .|  .. ..
vivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 241-469 1e-30 102.1 In-house 54-289 (298) alignment 
Range on Protein: 241-469
Range on HMM: 54-289/298.0
VSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDfLK
 .| .|||. |.| .|.||| |..      | || | ...  . ..| |.|| || .| .|||.|.....|... .. .  | .|   .  .|...   .
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.et

FEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSM-SGCGRAGTFALFETAHMSLH
...  ... . ..       .||| . .. . .. ..  |. .||  ..|.  . . .. .  |...    . || .   .| ||.|||   ..    ..
ygeitvsllskeefadlivrklkvskkkeekere.vrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervk

NEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
.|| .. . . .. .|. | ..||  .|.. .|... | 
keq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_PTPRB_pd Subfamily PTPRB 221-467 3.8e-30 99.9 In-house 28-282 (293) alignment 
Range on Protein: 221-467
Range on HMM: 28-282/293.0
VNEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWV-DLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMT
..|.|...       .....   | .|||. ...  |||||||      ..| || ||.. ..|| .. | || || .|  |||.|. ..| . ....  
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltq

DGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQVelgKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT----DGHPPVYM
  |  |   .  .|....   . |  . . . ...   . | .. |...... .. .. .|.. ||   .|.. |.. .    .|...    . .| |  
lvekgkvkCeeYWPadeepvlyGdikvtlvaeeel...edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

SMSGCGRAGTFALFETAHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
  .| ||.|||   ..   .... .  ....  . ..|. | . ||. .|. .... . 
CsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 221-470 1.1e-29 98.5 In-house 26-283 (319) alignment 
Range on Protein: 221-470
Range on HMM: 26-283/319.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
 .||.....  . .... .   | .|||. ... .|..||.|.      .| || |...|  .  .| | || ||..| .|||.|. .... .|...  .
ekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

GEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYM-SM
 |  |   . ..|. ..| ..    . . | .. |     .||.   |.      .  ..|..||   .| . ... ..   .|| ...  . |. .   
veklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCs

SGCGRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 | || |||   . | .   .|.  |.. .   ..|  |   ||. .|....|  . | |
aGvGRtGtfivld.amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPN23_pd Subfamily PTPN23 243-469 1.1e-29 98.1 In-house 43-279 (288) alignment 
Range on Protein: 243-469
Range on HMM: 43-279/288.0
NMDKNRFVDVICMDHSRVKLTDS--SYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKFEDR
. .|||. |..  ||.|||| .|   || | .|      . . | || ||  |..|||.|. .|| . . ....  | .|   .. .|....   ||.| 
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdl

FIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPS----DVKQIWQVQS-YLRKYTDGHPPVYM-SMSGCGRAGTFALFETAHMSLHN
 . . . .. |     .||.   .. . |.  |. ....||.  .|.     .. . .|.| |  .    . |. .   .| ||.|.|||  .|   |..
svtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelek

EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
..  |.... .. .|. | ..||. .|.  .|  . |.
gnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0049772 (Phosphotyrosine protein) phosphatases II 234-468 1.2e-29 99.4 In-house 37-278 (314) alignment 
Range on Protein: 234-468
Range on HMM: 37-278/314.0
HISKNHFVSNMDKNRFVDVICMDhSRVKL-----TDSSYIHANWVDLNssKKAILTQLPLSHTASDF----------WQMIIDQKIKCVLLIM-------
.| .  .. |.||||. |....| .||.|      .|.||.|..||    .| | || ||..|  ||          |.|........  . |       
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------TDGEFNKFggNSVFPQNQDFLKfedrfirvgefkqvelgkgwnlkvlSVS---NGTYKTFIHVHHYkNWPHGSIPsDVKQIWQVQS
                .   ..  |   ......||                         ..    .   .. |..... ..| || | . ......  
delsrLdaAlgKtpllildgng..neptaadlellk.........................eelydpelferlgikylri.pvpDgsap.lledfdefle

YLRKYTDGHPPVYMSMSGCGRAGTFALfeTAHMSLHNeqpSLNMVKCLENVRNGRL-----HSVQNLSQFSVVYTLIAE
..... .|.| .   ..|.||.|||..  .| . ...    ... ..|| ||. |      .....| |.  ..  . |
fieeadkggpvlvHCkaGkgRtgtfvv..aaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 241-469 2.2e-29 97.4 In-house 7-241 (250) alignment 
Range on Protein: 241-469
Range on HMM: 7-241/250.0
VSNMDKNRFVDVICMDHSRVKLTDSS------YIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFgGNSVFPQNQDfLK
 .| .|||. |.| .|.||| |  ..      || | ...  . .|  | || ||..|  |||.|....|.. .... .  | .|   .  .| ..   |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ek

FEDrfIRVGEFKQVELGkGWNLKVLSVSNGTYKTF--IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKY---TDGHPPVYMSMSGCGRAGTFALFETAHMS
. |  ..|  ... | .  .  ..| .|. . .    .   |. .||  ..|   . . .... ...    ..  | .    .| ||.|.|   ..    
yGd..vtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

LHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
|..|.  ... | .. .|. | |.|. |.|.. ||..| . 
lkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPN9_pd Subfamily PTPN9 239-470 2.6e-29 97.2 In-house 38-290 (297) alignment 
Range on Protein: 239-470
Range on HMM: 38-290/297.0
HFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQD
.  .|. |||. ||.|.|..||.|.       | ||.||.||    ||| | || || .| ||||.|. .|..  ....    |  .   .  .| ....
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

FLKFEDrfIRVGEFKqVELGKGWNLKVLSVSNGTYKTFIHVHHY--KNWPHGSIPSDVKQIWQVQSYLRKY--------------TDGHPPVYMSM-SGC
  .| |  ..| . . ||  . .. .|| ..| . .   .| |.    ||   .||. ... .| .  |..                  ||. .   .| 
saefgd..lsvsnve.veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRAGTFALFETAHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
||.|||. .. .   |.. .  ...|.... .|. | .|.|   |.   |  . |. 
GrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 206-466 3e-29 96.6 In-house 16-279 (290) alignment 
Range on Protein: 206-466
Range on HMM: 16-279/290.0
KLVAQETLKDDANIAVNEFEKVSGYLPPH-ISKNHFVSNM--DKNRFVDVICMDHSRVKLTDS---SYIHANWVDLNsSKKAILTQLPLSHTASDFWQMI
|. .. . |.  ..|.. .||.  ||| . . .. |  |    |||. ||.| | .|| | |     |.|||.|.       |||| .|  |. |.|.|.
kfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl.kamfiltqGalkdtvidiwrmv

IDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ-DFLKFEDRFIRVGEFKQVELG-KGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPSDVKQIWQVQSYLR
...|.  . ..    |  |   .  .|... . | | .  .   | .. .   .   | |  . .|  . . |. . | ||  |..     . ..   ||
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhl.kikswpdksvalstlallrtlrilr

KYTdGhPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
| . | | |    .| ||.|||.  |..   | . . .|....    .|| || |||   |. ..  ..
kas.G.pvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 209-470 4.4e-27 89.9 In-house 7-277 (307) alignment 
Range on Protein: 209-470
Range on HMM: 7-277/307.0
AQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT----DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQK
 |.||.   .  |.||.... . |  .. . | .| ||||. || |.|..|. ..     | |||||.. .    || | .| ||  |  .|| |.|..|
vqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

IKCVLLIMTDGEFNKFGGNSVFPQNQDF-LKF--EDRFIRVGEFKQVELG---KGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPS-DVKQIWQVQSyL
...|...    |  |   .  .| ..   | |  . . | | ..   .|    .  |.  | |  .     |.   ..|||   .|  ..  |  ...  
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea.v

RkyTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|   |  | |    .| ||.||          . . .   .| | .|..|. | ...|.  |.  .. .. |. 
r..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_PTPRA_pd Subfamily PTPRA 213-487 5.1e-27 89.6 In-house 27-311 (330) alignment 
Range on Protein: 213-487
Range on HMM: 27-311/330.0
LKDDANIAVNEFEKVSG-YLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKI
  ||..   .||. .    .   .       |..|||.|...  |.||| |.      .| || | ..|    | | | .| |...|  |||.|| .|| 
saddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqks

KCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGT---YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT-
  ....    | ..   .  .|. .  . . .  . | . . ..     .. |  ....|    .  ..  |.. ||.  .|.. . . ..   ..|   
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

-DGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLgNGIGKKDVEEQENSI
  . | |    .| ||.|||  ...    .. |.  ... . ....|. | . || . |.  .|  . |. |  |  . ||   |. .
qsagpivvhcsaGvGrtGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl.ygdteldvsslekhl
0041856 (Phosphotyrosine protein) phosphatases II 243-473 7.6e-27 89.5 In-house 1-174 (182) alignment 
Range on Protein: 243-473
Range on HMM: 1-174/182.0
NMDKNRFVDVICMDHSRvkltDSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMtdgefnkfgG----Nsvfpqnqdflkfedr
|.||||..|....||||    |..||.||... .    . |.|| || .|  ||..|. ...|.... .          .                    
nldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

firvgefkqvelgkgwnlkvlsvsnGTYKTFIHVHHYKNWPHGSIPSdVKQIWQVQSYLRKytDGHPPVYMSMSGCGRAGTFALFEtahM---Slhneqp
                           ..  .. ..| .|| ...|. . .. .     ..  .|.| .   . |.||.||...     .          
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaay...lmkkl......

SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
.... .... ||. | ..|....|. ... .. |..|..
gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 222-472 8.2e-27 89.1 In-house 24-282 (318) alignment 
Range on Protein: 222-472
Range on HMM: 24-282/318.0
NEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
.|.|..|     .   |     |  |||.....  ||.||||..      | || ||..| . .||| | .| ||..| .|||.|. .|. . ....   
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

GEFNKFGGNSVFPQNQDfLKFEDrfIRVGEFKQVELGKgWNLKVLSVSNGTYKTF--IHVHHYKNWPHGSIPSDVKQIWQVQSYL---RKYTDGHPPVYM
 |  |   .  .|...   ....  ..|   ..|||.. . |. ..|..   .    .. .|| .||  ..|... .. ..        . .. .| |  
eergkakvhryWPskgs.rsygk..lvvelkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
  .| ||.|.|   ..    ...|.  ... .  ...|. |   ||  .|. ..|. . | .  
CsaGvGrtGvfiavdillerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPN14_pd Subfamily PTPN14 223-469 1.3e-26 88.4 In-house 28-295 (300) alignment 
Range on Protein: 223-469
Range on HMM: 28-295/300.0
EFEKVSGY-LPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----SSYIHANWVDLNSS---KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
|.|...   .  ..|  .   | .|||| ||.  ...||.|.      . || |  .    .   .. | .| || .|  |||||. .|... ....  .
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

GEFNKFGGNSVFPQN---QDFLKFEdRFIRVGEFKQ-VELGKGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPSDVKQI----WQVQSYLRKYTDGH--
 |  |    . ||..   .. ..|. .|  . .|..  .      ||.  .  . ..| .|.  |..||   .|.|||.      .|||  || ..    
eedgkeksfkyfPkleskkktvefg.kfkvttkfsedsdsvittglklkhlpskeertvwhl.qytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

----PPVYM-SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
    ||| .    | ||.|   | .    .|.... .... | |. .|. | . ||.|.|.  ||... ..
keskPPvlvhCsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 240-467 3.8e-26 86.8 In-house 44-276 (288) alignment 
Range on Protein: 240-467
Range on HMM: 44-276/288.0
FVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFL
   | .|||. ... .|. ||||..      . || |...| . . || | || || .|  |||... ..|.. .. .    | .|   .  .|....  
lavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk

KFEDRFIRVGEFKQVElgkGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSMSGCGRAGTFALFETAHMSLH
.. .  . . | |..|    . |. | .   . .  |. ..|. ||  ..| . ... .. . .    .    | .   . | ||.|||   ...   ..
nyGsvtvtlveskele...dfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidave

NeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
. .  ....  ....|. |   ||.|.|.  .|  ..
e.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_CG7180_pd Subfamily CG7180 238-473 7.2e-26 85.5 In-house 37-293 (296) alignment 
Range on Protein: 238-473
Range on HMM: 37-293/296.0
NHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQd
..   |..||| |.|.  |. || |.      .| || | .||    ||  | |. |  .|  .||... |..|..|  .   ..|.|   .| .|... 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

FLKFEDRFIRVGEFKQVELGKGWNLKVLSV---------SNGTYKTFIHVHHYKNWPH-GSIPSD----VKQIWQVQSYLRKY---TDGHPPVYMSMSGC
  .. . |. . | ||    | ...|.               . .  ... ... |.   ..|.     .. . .|... .|     .  | | .|  | 
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
.|.| .   . | . | ...  ... . .  .|. | . |.|  ..  .| .. |.|| |
sRsGvylaid.anlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 232-470 8.2e-26 85.7 In-house 32-271 (288) alignment 
Range on Protein: 232-470
Range on HMM: 32-271/288.0
PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN
 .  . . |..|  ..|. .. . | .||||.| .  ||.|| |  .   .. | .| ||  |   .|.|.... .. ....    |  |   .  || .
asidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

QDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSN-GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAHM
.       |.  |   |.... |  .. .| .|. |  | .. . |...|.. ..| . .   ..   |....  .| | .|  | ||.||..|   |  
lGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq..kPivvhssaGvGrtgtlililiale

SLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
||  .   | . . |.. |. | ...|   |.  |. .. |..
slrldd.flgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Ptp69D_pd Subfamily Ptp69D 214-487 8.3e-26 85.8 In-house 17-302 (307) alignment 
Range on Protein: 214-487
Range on HMM: 17-302/307.0
KDDA-NIAVNEFEKVSGY-LPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKI
| |.    ..|.||.     .   .  .   |  |||. |..  |. ||||.      ||.|| |...     .|| |  | |.  |. |||.|| .|..
krdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqev

KCVLLIMTDGEFNKFGGNSVFPQNqDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGT----YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYL-RKY
. . ..   .| |.   .  .|.. |  ...|  ... .... .     .|.|  . . .     .  .  .||..|.   .|   . . .. . .   |
tlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

TDGHPPVYM-SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLgNGIGKKDVEEQENSI
   . |. .    | ||.|.|  ..     |..|. ......   ..|. |   ||.| |.. .|  ....    |   .||.. |..|
klnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldyss.ygdtdedvddledai
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 198-473 1.8e-25 84.9 In-house 14-295 (319) alignment 
Range on Protein: 198-473
Range on HMM: 14-295/319.0
SDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNH--FVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPL
 | .. . .|  .. ..|| ..   || ...   ..   ...     | ||||.....  |...|||        | || | .|.   . .| | .| ||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

SHTASDFWQMIIDQKIKCVLLIMtdgefnKFGGNSVFPQNQDfLKFEDRFIRVgefKQVELGKGWNLKVLSVSN-G--TYKTFIHVHHYKNWPHGSIPS-
  |  |||.|| ....  ..|.       |      .|.. .  | |   ..|   . ||  . . .. . .|. |  . .  |. .|.. ||.   |  
dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkv...dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy

--DVKQIWQVQSYLRKYTDGHPP-VYMSMSGCGRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE-HVLGN
  |. .. .  ..|..  ... . |    .|.||.|..  .. . ..  .|.  ... . ....|. | . ||.| |.  .|. . | |..|.
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld.vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 239-470 4e-25 83.3 In-house 16-264 (270) alignment 
Range on Protein: 239-470
Range on HMM: 16-264/270.0
HFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVD--LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD
... .   ||. |..   ..||.| .      . || ||.|    ...|| | .. ||  | ..||.||...| ......    | ..   .  .|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

F-LKFEDRFIRVGEFKQVElGKGWNLKVLSVS-NGTYKTFIHvHHYKNWPHGSIPSDVK----------QIWQVQSYLRKYTDGHPPVYMSMSGCGRAGT
  .|.|| .|.|   ...   .|. |. | .  .|. .  .| ..|..||  ..|..             . .|. . ..  ...| .     | ||.||
ekvkledgkikvlalseek.eegyiltrlrleekgeerrlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FALFETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
. . ..|   |. |. ...... .|..|. |   ||   |.  .|  ..|..
lialDiavrlLe.etkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPN6_pd Subfamily PTPN6 240-470 8.7e-25 82.3 In-house 51-297 (306) alignment 
Range on Protein: 240-470
Range on HMM: 51-297/306.0
FVSNMDKNRFVDVICMDHSRVKL-----TDSSYIHANWVD---LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF
 ..|. |||.  .. .||.||.|     ..| || || ..    .|.|. | ||  |..| ||||.|. ... . .... .. | .|      .|.... 
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

LKFEDrfIRVGEFKQvELGKGWNLKVLSVS---NGTYKTFIHVHHYKNWPHGSIPSDVKQI----WQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALF
 .. .  |.| . .. .  . ..|. ||||   ... .  .. .|.|.||  ..|.| ...     .|..  .. .  .  | |    .| || ||| . 
eeyGk..isvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

ETA--HMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
..    .. .  .  ... |. . ||. |   ||  .|.  ||. |....
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPRG_pd Subfamily PTPRG 240-482 1.3e-24 81.3 In-house 44-301 (563) alignment 
Range on Protein: 240-482
Range on HMM: 44-301/563.0
FVSNMDKNRFVDVICMDHSRVKLT-----DSS--YIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDF
  .|  ||| .... .|.|||||.     ...  || ||..|  . ||. | || || .|. |||.|| .|. . . .|    | ..   .  .|. .. 
kpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.des

LKFEDRFIRVGEFKQVELGKGWNLKVLS--VSNG---TYKTFIHVHHYKNWPHGSIPSD-VKQIWQV-QSYLRKYTDGHPPVYMSMSGCGRAGTFALFET
....   ..  | ... |    .|..    . ..    ..  .  .|| .||  . |.  . ..  | .|   . ..  | |    .| ||.||.  ..|
etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldt

AHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNG--IGKKDVEE
 .  ...|. . |. . |  .|  | . ||.  |.  ..  . | ....   . ...|||
llkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 237-469 2.3e-24 80.9 In-house 22-267 (274) alignment 
Range on Protein: 237-469
Range on HMM: 22-267/274.0
KNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
. .   .  |||. ...  ..||| |        ||||| ||..      ||  . || ||..| .|||.||  .... ....    | |.   .  ||.
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

NQDFlKFEDRFIRVG-EFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYL---RKYTDGH--PPVYMSMSGCGRAGTFAL
..|. . ..|.. |  .....   ...... |.... . .  .. . | .||    | |.... ..       |. .. .  | |    .| ||.| |  
aedy.eiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

FETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
 . |   |..|.  ....|   |.|  |   ||. .|. ...  ....
isiavrqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 241-473 4.6e-24 80.4 In-house 23-259 (284) alignment 
Range on Protein: 241-473
Range on HMM: 23-259/284.0
VSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMtdgefnKFGGNSVFPQNQDfLK
  | ||||.....  |...|||        | || | ..    . .| | || ||  |  |||.|| ....  ..|.       |      .|.. .  |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ik

FEDRFIRVgefKQVELGKGWNLKVLSVSN-G--TYKTFIHVHHYKNWPHGSIPS---DVKQIWQVQSYLRKYTDGHPP-VYMSMSGCGRAGTFALFEtAH
 |   ..|   . ||  . . .. . .|. |  . .  |. .|.. ||.   |    |. .. .  ..|..  ... . |    .|.||.|..  .. . 
eerfkvkv...dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld.vl

MSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE-HVLGN
..  .|.  ... . ....|. | . ||.| |.  .|. . | |..|.
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 243-473 9e-24 79.1 In-house 51-287 (297) alignment 
Range on Protein: 243-473
Range on HMM: 51-287/297.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSkKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPqNQDFLKFED
|..|.|. ... .| |||||       || |. | .|  |   . | || |   |  |||.|..|.... ....  | | .|      .. ..   .| |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvttfGd

RFIrvgEFKQVELGKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPS--DVKQIWQVQSYLRKYTDG--HPPVYMSMS-GCGRAGTFALFETAhMSL
  .   . . |.  .|   . |.|..|    . ... ... .||. ...   ..... .. | .||  ..  . |. .  . | ||.| .   .   .. 
vsv...vllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv.vae

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
 ... .... . .. .|. | . ||   |.. || .. | .| .
akrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 222-480 1.6e-23 77.8 In-house 15-275 (281) alignment 
Range on Protein: 222-480
Range on HMM: 15-275/281.0
NEFEKVSGYLPPHIS--KNHFVSNmDKNRFVDVICMDHSRVKLTD-------SSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIM
.|| .. |  |  .    |. | |  |||.... |.| |||.|         . |||||..     |.  |||| |   | .|||.|| ...  ..... 
qefsnlpgdppsdlctvfnqpvnn.kknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

TDGEFNKFGGNSVFPQNQDFLKFEDRFIRvgEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKytDGHPPVYMSMS
   | |.      ||.|       |..    ....  . |      | .|      .|    .|.||   .|   . . ..   .|      |||    .
qfletnrekcaeyfprnahcclqfdklsv..syedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira..rstppvihcsa

GCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVR-NGRLHSVQNLSQFSVVYTLIaehvLGNGIGKKDV
| ||.||.   | |  |.|.     .. . .  .|  ||  ||| | |. ... ..    |  |.  |..
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl....ldfgvaykqi
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 241-472 3.2e-23 77.3 In-house 46-290 (325) alignment 
Range on Protein: 241-472
Range on HMM: 46-290/325.0
VSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKAIL-TQLPLSHTASDFWQMIIDQKiKCVLLIMTDGEFNKFGGNSVFPQN----Q
  |..|||| .|. .|.||| |       .| || |...  .  |.  | .| ||..|  |.|....| .   |....   . .|      .|..    .
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksk

DFLKFEDRFIRVGEFkqvELGKGWNLKVLSVSNGTYKTfIHVHHYKNWP-------HGSIPSDVKQIWQVQSYLRKYTDGHPPVYM-SMSGCGRAGTFAL
 |  .| ... . |.          |.|  |..|  .. ..  ... |.         .. | .. . .|.  ..  | .  |. .  ..| ||.|.|. 
tfGglevklrtieei...sdyvhrvldvkqvkkGetrs.vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

FETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
. .|   .  |. .... . ....|. |   |.   |....|. ..| .. 
lysalakvi.eesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 221-470 1.1e-22 75.6 In-house 25-283 (305) alignment 
Range on Protein: 221-470
Range on HMM: 25-283/305.0
VNEFEKVSGYlPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
 ......    .  |  ..   |  |||..... .|..|..||      || || |..||   ..|| |..| || .| .|||..|.. |.. ....   
eaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltkl

GEFNKFGGNSVFPQNQDF-LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG---HPPVYMS
 | .|   .  .|...    .|..  . . ..|...     .||.   ..   .  .  ..  .||   .|     . ..   ..|        | .   
veggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC

MSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
  | ||.|.|   . |   |..|. .... . | ..|. |.  ||.| |.  ..  ..| .
sagvgRtGvfiavdialerlkkEe.vvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 235-468 3.1e-22 73.8 In-house 38-281 (290) alignment 
Range on Protein: 235-468
Range on HMM: 38-281/290.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLT------D--SSYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVF
.  .   ||  .||| ...  |  |. |       |   .||.| ...  . .|. |.|| |.|.|. |||..| ..|. .......  | .|   .  .
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PQNqDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWP-HGSIPSDVKQIWQVQSYLR-KYTDGHPPVYMSMSG-CGRAGTFALF
|.. |  ...   |.. . ....     .|.| . ... .|. .. .. .||. .|...     . ...   . .. .|  .. .  |.  ||...|   
pds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaa

ETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
.|.    . |.   .... |.. |  .  |||   |. ...... .
attinkckteg.vidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_PTPRK_pd Subfamily PTPRK 242-471 3.4e-22 73.7 In-house 42-278 (314) alignment 
Range on Protein: 242-471
Range on HMM: 42-278/314.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFlkF
 | .|||. |.. .|.|||.|.      .| || |...|  . ... | || || .|  |||... |..  .....    |  ..     .|.. .   .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..y

EDrfIRVgEFKQVELGKGWNLKVLSVSN--GTYK--TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAhMS
.|  |.| |. ..|| .    ....|..   ...    ..  .. .||.  .|   . . ..   . | .  .  . |   ..|.||.|||   ..  . 
gd..ikv.elvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv.ld

LHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
. ...  ... ..  ..|. .   |.   |.  .|  | | .|
mieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 223-470 4.7e-22 73.3 In-house 29-280 (315) alignment 
Range on Protein: 223-470
Range on HMM: 29-280/315.0
EFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
..| . |     .   . . | .|||....| .|.|||.|       .| |. ||..|  |  .. | .| |.  .  |||... ...|  ....    |
dyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlve

FNKFGGNSVFPQNqdFLKFEDrfIRVGeFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGH--PPVYMSMSGC
 .|   .  .| .   . .    | |   |. |  . .  . |||  |     .   ||  ||   .|     . ..    ... .    . |    .| 
gekrkaekywpdk..kviyGk..itvt.rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGv

GRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH-V
||.|||  ...    .. |.  ... . ...||. | . || . |.  .|  . |  |
GrtGtfitldavldqaeaen.aidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 220-470 5.1e-22 72.9 In-house 26-289 (305) alignment 
Range on Protein: 220-470
Range on HMM: 26-289/305.0
AVNEFEKVSGYLPPHISKNHFVSN------MDKNRFVDVICMDHSRVKLTD---SSYIHANWVD--LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVL
  .|| ... |  | .... | .|      . |||. || | |.| ||| .   | |||||.|   .   |. | .| || .|  .|| |.|..|.. ..
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqiv

LIMTDGEFNKFGGNSVFPQNQDF---LKFEDRFIRVGEFKQVELGKGWNLKVLSVSN-GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHP
..    |  |.     .|  |     ||       |   | .|     .. .| ..  |  |  .   .. .||   .|       .. | .|      |
mlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk..vp

PVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 |    .| ||.||    |     . ...|   | . .  .|. | .|.||  |.  .. .. ...
ivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 242-482 1.3e-21 71.7 In-house 47-299 (305) alignment 
Range on Protein: 242-482
Range on HMM: 47-299/305.0
SNMDKNRFVDVICMDHSRVKLTDS---SYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
 . .|||. || |.|. ||||  .    |||||.|   . .|. | || || .| .||| | ...|.. ....    |         |. ...| |.||.
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

RFI----RVGEFKQVELGKGWNLKVL----SV-SNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYtDGhPPVYMSMSGCGRAGTFALFETAHM
.      ..   ..... |  . ||      .   |. .  .  .|. .||   .|.    | ..    |    | | |    .| ||.|.  ..|    
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.kg.pivvhcsagigrtgsvvmleyild

SLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEE
 | . |   .  | |  .|. |  |.|   |.  |. .| .... ... ...|.|
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevke
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 235-470 2.8e-21 70.8 In-house 39-278 (287) alignment 
Range on Protein: 235-470
Range on HMM: 39-278/287.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLTD--SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDf
.  |   .| ||||. ...  |  || | .    || | ..|  ..||| |... |...|| .||..| |.... ....  . | ..      .|...  
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWP-HGSIPSDVKQIWQVQSYLR-KYTDGHPPVYMSMS-GCGRAGTFALFETAHMS
. . .  |.. . .. .     .|.|   .. . |  .. ... ||. .| ...    . ...   . ..  |. .. .  | . ||...|   .|.   
vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink

LHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 ..|   ..... |.. |  . .|||  .|.  .. .. |..
ckte.GviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 240-471 7.3e-21 69.3 In-house 41-278 (315) alignment 
Range on Protein: 240-471
Range on HMM: 41-278/315.0
FVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ-NQDF
   |. |||. ... .|..||||       || || |  .    . |  | .| ||  . .|||.|....|.  . ..    | .|   .  .|. . | 
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

LKFEDrfIRVGEFKQVELGKGWNLKVlSVSNGTYKTFIHVHHYKNWPHGSIP----SDVKQIWQVQSYlrKYTDGHPPVYMSMSGCGRAGTFALFETAhM
 .|    |.|  ..    . | . |.  . ..  .  .  .....||.  ..    | .| | .|..   . .. .. .   ..| ||.| .   .   .
vefGs..ikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidev.v

SLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
.  ... |... . ..|.|. | . ||   ... .|  . |..|
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPRN_pd Subfamily PTPRN 238-470 8.3e-21 69.0 In-house 51-292 (297) alignment 
Range on Protein: 238-470
Range on HMM: 51-292/297.0
NHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA--ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ
 .   |..|||  .|.  |||||||..      | || |  .  .  ...  | || ||..| .|||||. .| .  .. . .  | .    .  .|.. 
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG

DF--LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGtyKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGH--PPVYMSMSGCGRAGTFALFETA
      .| ...    . .  | . . || |  |.   .| .   |.  ||. ..|.  | . . .  . |   |   | |  ...|.||.|.. | .  
sevyhiyevhlvsehiwcddylvrsfylknlqtset..rt.vtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv

HMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
   | .    ....  || .|. | . |.  .|| ...| .|| |
lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 242-471 8.3e-21 68.6 In-house 42-277 (515) alignment 
Range on Protein: 242-471
Range on HMM: 42-277/515.0
SNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ-NQDFLK
 |  |||. ... .| .||||       .| |. |  .   .. |  | .| |.  . .|||........  . ..    | .|      .|.   | .|
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

FEDrfIRVGEFKQVELGKGWNLKVLSVSNGTYKTfIHVHHYKNWPHGSIPS----DVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAhMSL
|    |.|        . |   |.  . .  ..| .  .|...||.  .|      .| | .|..   .||  || .   ..| ||.| .   .   .. 
fGs..ikvelvsleactggikrkltvlkgddsrt.vtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsv.vah

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
 ..  .... . ..|.|. | . ||   |.. .|  . |..|
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0046846 (Phosphotyrosine protein) phosphatases II 263-467 2.4e-20 68.5 In-house 10-170 (176) alignment 
Range on Protein: 263-467
Range on HMM: 10-170/176.0
TDSSYIHANWVDLNsskKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKfedrfirvgefkqvelgkgwnlkvlsvsn
 |..||.||... .   . | || || .|  ||..|. ...|..|. .... |.....    .|. ...                               
ldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

gtyktfihVHHYKNWPHGSIPSDvKQIWQVQSYLRKYTDGHPPVY-MSMSGCGRAGTFALFEtahmsLHNEQPSLNMVKCLENVRNGRL-HSVQNLSQFS
         ... .|| ...|.. ......  ..|.. . . ||.   . |.||.||...       |   .  |.. ..|. ||. |  ..||. .|  
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqtpeQyr

VVYTLIA
 .|  . 
flyefel
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 214-470 3.9e-20 66.7 In-house 16-279 (439) alignment 
Range on Protein: 214-470
Range on HMM: 16-279/439.0
KDDANIAVNEFEKVSGYLPPHISKNHFVS---NMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQK
|.. .|  ..|||..   |..  .  ...   .  |||. ||  .||.|| |        | || ||...     |  | || |  .|. |||...|..|
knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

ikCVLLIMTDGEFNKFGgnsVFPQNQDFLkFEDRFIRVGefKQVELGK--GWNLKVLSVSNGTYK-TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT
  .| ..|    .. .     .| ...   . |  .||   ...|| .     .||.   . | |   .   ||  ||.  .|..   . .    .    
..tvtivmltnlvesyk...ywpsdaevc.ygdiavrvd..rnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

D---GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|     | |    .| ||.||   .. |   |. |.  ...   .. .|. | . ||.| |. ..|  . | .
dkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 234-463 4e-20 66.7 In-house 41-279 (301) alignment 
Range on Protein: 234-463
Range on HMM: 41-279/301.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS---YIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN-
|| . .   . ||.|.  | |  .. |.. .      |||||.. .  ... | || ||. |. ||| |..  ... . ..    | ..   .. .|.. 
hitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

QDFLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSNGTYK----TFIHvHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFET
.. |. .   |.. . ... | |  . . | | . | |    | .| . |..|..  .|    .....   ..|    .| |    .| ||. .|   | 
sekldigrfkikiknkeli.lnkkiskrtlevedstgkfatrtvth.yqysewtdrgvPkshaelfdlmelvkkse..kPivvhcsaGiGrsvafigtey

AHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFS-----VVY
    ... .| ... . |...|. | ..||. ||.       ||
larevea.dptieltealkhlrehrwngvqtnsqlywmtlGtvy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 234-470 1.7e-19 64.9 In-house 24-259 (267) alignment 
Range on Protein: 234-470
Range on HMM: 24-259/267.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLTDS--SYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfgGNSVFPQNQD
 ||.     | ..||. |..  |..|| | ..   || | .|.    |.| |.|| ||. | .||...|.|||.  . |... .. |        |.  .
tisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni..rlfwPPkmgq

FLKFEDRFIRVGEFKQVELGKGWNLKvLSVSNGTYKtFIHVHHYKNWPHGSI-PSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSL
  |..|  .     |. .  .   |. | . | . .  . ...||.|   .     .| .. . .  .    ..| |     | ||.|||   ..    .
akkyqdltvehslekeendyqiitle.lkfknesah.nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

HNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 .|.  ... . | ..|. |   |. . ..  .. |.||. 
kteg.vsdifdflrkirsqriglvdtkeryiyihellaeya
0043147 (Phosphotyrosine protein) phosphatases II 264-463 2.7e-19 65.0 In-house 4-154 (172) alignment 
Range on Protein: 264-463
Range on HMM: 4-154/172.0
DSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDgefnkfggnsvfpqnqdflkfedrfirvgefkqvelgkgwnlkvlSVSN
.| ||.|...||.    . | || ||..| .|||.|. ...|.... ...                                               .  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

GTYKTFIHVHHYKNWPHGSIPsDVKQIWQVQSYLRK---YTDGHPPVYMSMSGCGRAGTFALFETAHmslhneqPSLNMVKCLENVRNGRLHSVQNLSQF
  .. ..  ..| .|| .. | . ...... .....     .|.| .   . |.||.||...    .        .|.. .... ||. | ..||| || 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy

SVVY
  .|
rfly
0051429 (Phosphotyrosine protein) phosphatases II 264-469 4.4e-19 64.6 In-house 3-224 (272) alignment 
Range on Protein: 264-469
Range on HMM: 3-224/272.0
DSSYIHANWVDLNSS----KKAILTQLPLSHTASDFWQMiIDQKIKCVLLIMTDGEFNKFGGNSVFP-----------QNQDFLKFEDRFIRVGEFKQVE
 |.||.|..|. . .    .. .... || .|| |||..  ...||... .... | ....   . |               .  . . .... .... .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVkqIWQVQSYLRKytdGHPPVYMSMSGCGRAGTFALFETAHmSLHNEQPSLN--------MVK
    ..| .  ... .    ... || .||  ..|..   . .. ..|..   |.| ..  ..|..| ||...         ...  ..        . .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlylee

CLENVRNGRLHSVQNLSQFSVVYTLIAEH
..| .|  | ..||.  |.  .|  ..| 
aveelraqrpgavqteeqylflyeallel
PTPc_DSPc_SM00012 369-468 4.7e-19 63.9 In-house 2-105 (105) alignment 
Range on Protein: 369-468
Range on HMM: 2-105/105.0
IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD----GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYT
... ||..||. ..|.... | ..  ...| .     ..| | ..  |.||.|||.........|..|. .... .... .|. | ..||.. |....|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LIAE
 ..|
alle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 221-312 3.8e-18 60.1 In-house 30-127 (310) alignment 
Range on Protein: 221-312
Range on HMM: 30-127/310.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT-D----SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMT
|... |.     . .. . .  .| |||. ||.|.| |||||. |      |||||.|  |  ... | .| || ||  |||.||.... . .||.  
vkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 234-483 4.1e-18 60.1 In-house 34-289 (312) alignment 
Range on Protein: 234-483
Range on HMM: 34-289/312.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD
      |.   | ||. .. | |  |  |.  .  |||||.| . .  .  . || ||  |.. |||. .     ...|. .  |           .   
dsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

FLKFEDRFIRVGEFKQVELGKGW-------NLKVLSVSNGTYKTFIHvHHYKNWPHGSIPSDVKQIWQVQSYLRKytDGHPPVYMSMSGCGRAGTFALFE
|...||  .      ..|.|           |||.  . |    . | . .  ||   .|  .    .. | ..|  | .| .    .| ||.||.|| |
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnh.yqwaswpdhgmpdscdtalrllsavkk..dkkpviahcsagvgrtgtlalie

TAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEEQ
.   .|   .   |. . .  .|. |  ||. . |.  .   . | .  .|. |.. .| 
smiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqew
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 240-471 2.2e-17 57.6 In-house 42-237 (392) alignment 
Range on Protein: 240-471
Range on HMM: 42-237/392.0
FVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWV-DLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMT--DGEfnkfggnsvfpqnqd
   |. |||. ... .| .||||      .|| |. | ..  ... |  | .| | . . .|||.|. ....  . ..    .|.               
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

flkfedrfirvgefkqvelgkgwnlkvlsvsNGTYKTFIHVHHYKNWPHGSIP----SDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAH
                               .|  .  .  .|. .||   .|    | .| | .|..   .||  || .    .| ||.|     ..  
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..hpliihcsagvgrtgvvisidsvv

mSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
 .  ..   ..... . |.|. | . ||   |....|  . | .|
.ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 211-468 7.4e-17 56.0 In-house 6-275 (287) alignment 
Range on Protein: 211-468
Range on HMM: 6-275/287.0
ETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----SSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKI
   ||| .  |. . . |   .    . . . .. |||. ||. .|..|| |.      |.|| ||.|   .  .. | .| |.. |  |||....... 
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrs

KCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVgeFKQVELGKGWNLKVLSVSNGTYK--TFIHVHHYKNWPHGSIPSD----VKQIWQVQ---SY
  |...  . |  .      .|...  ..     . .  ...  .   .  . | . .   .    ..  .. .|| ....      .. . .|.     
asvitmtreveearlkcykywPerevPmrvGGysvvl..ldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

LRKYTDGHPPVYMSMSGCGRAGTFaLFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
 |. ..  |.|     | ||.|.. |   . .|  ..   ... . .  .|. |   ||   |. ..|  .. 
ardasevGPlvvhddvGiGrsGil.latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 219-472 3e-16 54.2 In-house 10-268 (283) alignment 
Range on Protein: 219-472
Range on HMM: 10-268/283.0
IAVNEFEKVSgyLPPH-ISKNHFVSNMDKNRFVDVICMDHSRVKLTDS--SYIHANWVD----LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIM
.  . ....|  .|.     .    |  |||. ... .|  ||.|     .|| | ..      . .|| | .| || .|  |||.|. |.|| ..... 
lfrevlkrls..vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

TDGEFNKFGGNSVFPQNQdFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSNG-TYKTFIHVHHYK--NWPHGSIPSDVK---QIWQVQSYLRKYTDGhpP
   | ..      .|..    .. .  . . .       . .  | | . .  . |. . . ||.  .| . .  . .    .. .|.|  ..  .|  |
klqedlrikCsqyWPkrG.sedyGeftvtlrkett...snsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg..P

VYMSM-SGCGRAGTFALFETAhMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
. .   .| ||...|    .. .     .  ... . ....|. |   ||.| |. .|..|. |. | 
ivvhCstgiGrtavfiaasas.vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc
0036282 (Phosphotyrosine protein) phosphatases II 265-463 1e-15 53.3 In-house 2-163 (174) alignment 
Range on Protein: 265-463
Range on HMM: 2-163/174.0
SSYIHANWVDLNS-SKKAILTQLPLShtasdFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnqdflkfedrfirvgefkqvelgkgwnlkvlsvSNG
|.||.|...||.  ... |..| ||.     ||.|. ...|..|.  ..  | ....    .|                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

TYKTFIHVHHYKNWPHGSIPSDVKqIWQVQSYLRKY---TDGHPPVYMSMSGCGRAGTFALFETAHMSLHneQPSLNMVKCLENVRNGRLHSVQNLSQFS
 .. ... ..| .|| .. |.. . .... ......    .|.| .   . |.||.||...    .. |.  ..  . .. .  .|. | ..||. ||. 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

VVY
 .|
fly
0049260 (Phosphotyrosine protein) phosphatases II 278-463 1.1e-15 53.1 In-house 8-143 (152) alignment 
Range on Protein: 278-463
Range on HMM: 8-143/152.0
SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFpqnqdflkfedrfirvgefkqvelgkgwnlkvlsvsngtyktfihVHHYKNW
....| || |...|..|||.|. ...|.... .... |..|.. .  .                                              ... .|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

PHGSIPSDVKQIWQVQSYLRK--YTDGHPPVYMSMSGCGRAGTFALFETAHmslhneqPSLNMVKCLENVRNGRLHSVQNLSQFSVVY
| .. |..   . ..   ..|    .|.| .   . |.||.||...    .         ... .... ||. | ..|.| .|   .|
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 243-464 8.6e-15 49.5 In-house 7-234 (239) alignment 
Range on Protein: 243-464
Range on HMM: 7-234/239.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWV-DLNSSKKA-ILTQLPLSHTASDFWQMIIdQKIKCVLLIMTD-GEFNKFGGNSVFPQNQDflK
|  |||. ...  ||||| |        | || |... | . | || | ||  .. .. |||.|.  |. .||....|   |  |      .|..    |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmw.qerrcvivmltglieghkkkchqywpdsts..k

FEDrfIRVGeFKQVELGKGWNLK--VLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFEtAHMSL
. .  .||  ... |.   . ..  |.|    | . ... .|.  ||   .|     .  ..  . | .    .| |    .| ||.|.| . . | .  
ycn..lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid.amlrq

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYT
 ..| ...... .. .|. | | ||   |. ... 
akkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 243-463 9.3e-15 49.4 In-house 8-234 (239) alignment 
Range on Protein: 243-463
Range on HMM: 8-234/239.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWV-DLNSSKKA-ILTQLPLSHTASDFWQMIIdQKIKCVLLIMTD-GEFNKFGGNSVFPQNQDflK
|  |||. ...  ||||| |        | || |... | . | || | ||  .. .. |||.|.  |. .||....|   |  |      .|..    |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmw.qerrcvivmltglieghkkkchqywpdsts..k

FEDrfIRVGeFKQVELGKGWNLK--VLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFEtAHMSL
. .  .||  ... |.   . ..  |.|    | . ... .|.  ||   .|     .  ..  . | .    .| |    .| ||.|.| . . | .  
ycn..lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid.amlrq

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVY
 ..| ...... .. .|. | | ||   |. ...
akkqktvdifnyvkairedrphmvqtseqyvfih
subfamily_egg_pd Subfamily egg 242-473 6.8e-14 46.2 In-house 39-276 (307) alignment 
Range on Protein: 242-473
Range on HMM: 39-276/307.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfgGNSVFPQN-QDFLK
 |..| |   | | | |||||          .|||| |. .    . ||.| ||  |  |||.|.  .... .... .  | ..   .  .|.  .| |.
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser..ceyywpkaesdslv

FEDRFIRVGEFKQVELGK-GWNLKVLSVsNGTYKTFIHVHHYKnWPHgSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAHMSLHNE
.    .|.  .|  .     ...  | .  |. .   .. |.. .      |||    .|   ||. .  .| |  .. |. .|.|.   |.| .||   
tvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwq.gdv.nnssdvysplrvlrklrnls..kpvvvqdilGvskaatlvaieiallsllrG

qPSL--NMVKCLENVRNGRLHSVQNLSQFSVVYTLIA---EHVLGN
 |     . ..   .|  |  ||.   ..  || |..     |.|.
.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs
0044763 (Phosphotyrosine protein) phosphatases II 256-466 7.5e-14 47.2 In-house 3-167 (178) alignment 
Range on Protein: 256-466
Range on HMM: 3-167/178.0
DHSRVKLT------DSSYIHANWVDLNsskkAILTQLPLshtaSDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDflkfedrfirvgefkqvel
|..||.|.       | ||.|.... .     .|..||     .|..... ...|.... . .. | .... .  .|.. .                   
drtrvllsnleglersdyinaseilpg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

gkgwnlkvlsvsngtyktfIHVHHYkNWPHGSIPSDVKQIWQVQSYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSlhneqpSLNMVKCLENVRN
                   |...|. ..| .. |.  ......  .....  ..|.| .   . | ||.||...    ..       .|.. ...| ||.
...................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvre

GRLhSVQNLSQFSVVYTLI
 |   |.| .|   .| . 
rRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 258-481 1e-13 44.6 In-house 91-320 (346) alignment 
Range on Protein: 258-481
Range on HMM: 91-320/346.0
SRVKLTDSSYIHA---NWVDLNSSKKAILTQLPLSHTA---SDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQDFLKF-EDRFIRVGEFKQVELG
||   .  .|.|     .| ..  .| |..|||  .      ||| || ...|. | |.. |  ...    |.| ...   ..    ||           
srrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkn.tttslfndenggyqytgkmfinnrradvsgdp

KGWNLKVLSVSNGTyKTFIHVHHYKNWPHGSIPSD----VKQIWQVQSYlrKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVR
| . ..||   |       .|||.  | |   |      .| | |  |   |         .|. ||||| .|     |   | |     |... . |..
keytievlpegnsd.svicqvhhhapwkhlqqppktlpiikmihqflse..kqvqnagvcvvslfgcgracsfigalyainqlnng.iepniceimknik

NGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVE
. |  .|. ..|.. .|... ...     |||.  
qqrpggvesfaqyasiyaivfdyiarkrggkkapv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 243-466 1.6e-13 45.4 In-house 3-235 (237) alignment 
Range on Protein: 243-466
Range on HMM: 3-235/237.0
NMDKNRFVDVICMDHSRVKLT----DSSYIHANWVDL--NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFED
|  |||. .....||||| |     .| || |....    . || | .| ||  .  |||||. ..|   ....    | |.      .|. ..   .  
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

rfIRVGEFKQVELGKgWNLKVL-SVSNGTYK--TFIHVHHYKNWPHGSIPSDVKQIWQVQSYL----RKYTDGHPPVYMSMSGCGRAGTFALFEtAHMSL
  . |   |. |.   . .. |  . ..| |   .|| ...  ||.  .|     . . .  .    .. ..  | .    .| ||.| | . . | .  
..ltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid.amlrq

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
 .|.  ... . . .. . | . .|   |. ...  |
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0051082 (Phosphotyrosine protein) phosphatases II 265-465 2.7e-13 45.3 In-house 3-148 (151) alignment 
Range on Protein: 265-465
Range on HMM: 3-148/151.0
SSYIHANWVDLNsskkAILTQLPLShtasDFWQMIIDQKIKCVLLIMTDGEFNkfGGNSVFPQNQdflkfedrfirvgefkqvelgkgwnlkvlsvsngt
|.||....|. .     .... ||.    ||.... ...||... .... | .     . .|...                                   
sdyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

ykTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKyTDGHPPVYMSMSGCGRAGTFALFETAHMSlhneqpsLNMVKCLENVRNGRLHSVQNLSQFSVVYT
    ..  .. .||  ..|   ... .. ..|.. ....| .   ..|.|| ||...    ..        ... ..|| .|  | ..||   || ... 
..ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlf

L
 
a
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 235-393 4.7e-12 40.4 In-house 25-190 (297) alignment 
Range on Protein: 235-393
Range on HMM: 25-190/297.0
ISKNHFVSNMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN---SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
 |  .  | . |||. |.. .| .||||    |.. || |..| .    .  | ||.| ||| |  |||... .| .. . ..    |  .      .|.
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

NQ-DFLKFEDRFIR-----VGEFKQVELgkgWNLKVLSVsnGTYKTFIHVhHYKNWPHGSIPSDVKQIWQVQ
 . . ||  |  .        ||..| |    .|...       .   ||  . .||   .|||.... . |
vvqerlkagdvvveflsstsdefdrvil...telqliyr..sesrvvrhv.qflswpdhGvpsdledlvrfq
subfamily_ptpA1_pd Subfamily ptpA1 234-322 7.7e-12 39.7 In-house 38-132 (418) alignment 
Range on Protein: 234-322
Range on HMM: 38-132/418.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGN
  |.     |  |||. ... ..|.||.|        | || ||..|    |. | || ||  | .|||.|. ... . ....  . |  .   .
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 263-464 1.2e-11 39.3 In-house 44-253 (290) alignment 
Range on Protein: 263-464
Range on HMM: 44-253/290.0
TDSSYIHANWVDLNSSKKAILTQLPLSHT-------ASDFWQMIIDQKIKCVLLIMTDGEFNK----FGGNSVFPQNQD-FLKFEDRFIRVgefKQVELG
  . ||||| |   .  . |||| |. ..         .|| |. . |.| |  .    | ..    |  .  .|.. .  |||..  ..    |. |  
fnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC...kskeke

KGWNLKVLSVSNGTYKTFIHVHH-YKNWPHGSIPSDVKQIWQVQSYLRkyTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGR
.. . . | |  .  . |   |. .|.| . ... | | . .. ....  . . | .   . |  |  ..|  . .   . . . |..... |...|. |
ddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

LHSVQNLSQFSVVYT
 . ...  ... |  
alaitsalelafvda
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 237-310 7.7e-11 36.0 In-house 28-107 (332) alignment 
Range on Protein: 237-310
Range on HMM: 28-107/332.0
KNHFVSNMDKNRFVDVICMDHSRVKLTD----SSYIHANWVDLNSSKKA-ILTQLPLS-HTASDFWQMIIDQKIKCVLLI
 ..|. ||| ||   . |.|||||.|.       .  |.|||  | | | |..| |.  ||   ||.|. ..|   .|..
ydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 236-467 1.1e-10 35.8 In-house 44-290 (301) alignment 
Range on Protein: 236-467
Range on HMM: 44-290/301.0
SKNHFVSNMDKNRFvdvICMDHSRVKLTDSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ----D
.... ....|.||.   |   .....|.  .|| |...|  |. || | .| |. .|  |||..|...|   .. ..   |  |   .  .|. .    .
nrfknitvyddnri...ilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

FLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSN-GTYKTFIHV-----------HHYKNWPHGSIPSDVKQIWQVQS--YLRKYTDGHPPVYMSMS-GCGR
| .|.  ..    . .  . .  |.|.  .|| |  .  ..|            .  .||.  .  . . . ||      |.   |  ||    | . .|
fgpftvtlvneqvyPdf.virqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsr

AGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
.|..   . .      |    ....  . ||  .   |. | |.. .|  | 
sGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_eak_pd Subfamily eak 203-376 1.7e-10 34.8 In-house 11-186 (332) alignment 
Range on Protein: 203-376
Range on HMM: 11-186/332.0
TKWKLVAQETLKDDANIAVNEFEKVSGYLPP-HISKNHFVSNMDKNrFVDVICMDHSRVKLTDS-----SYIHANWVDLNS-SKKAILTQLPLSHTASDF
 || |. .. . .  |  .|  ...  | .   ||.   . ....|  |...  |.  |.|| |      || |  ....   .| ||| ..       |
ekwilinknhiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfaf

WQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ-DFLKFEDRFIRVGEFkqVELGKgWNLKVLS--VSNGTYKtfihVHHYKN
|||...||  ... .. | | .    .  ||..  . |||    .   ||  |. ..  . . |   . | |..    |.||| 
wqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrni.letrllelskGnethr....vlhykv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 241-317 1.8e-10 35.1 In-house 45-142 (350) alignment 
Range on Protein: 241-317
Range on HMM: 45-142/350.0
VSNMDKNRFVDVICMDHSRVKLT--------------DSSYIHANWVDLN-------SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFN
|  . |||.....  .||||||                . || ||.. |.       .. | | || ||  |  ||...|.  |.| .| . .| |.|
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 224-311 1.5e-09 31.9 In-house 18-117 (347) alignment 
Range on Protein: 224-311
Range on HMM: 18-117/347.0
FEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----------SSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIM
 |....| |.... . .  ...|||  ||  .| .|| |.             .|| |  . . |.||. |||| || .|  |||.|.   |.  |. |.
denlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 286-466 7.4e-09 30.0 In-house 39-217 (255) alignment 
Range on Protein: 286-466
Range on HMM: 39-217/255.0
LplshTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKFEDRFIRVGEFKQVELGKGWNLkvLSVSnGTYKTFIHV--HHYKNWPHGSI
|    |   |.|.|. .| . | ..    | ..   .| || ..|  ||..|  . . .  .  . .  ..  .|   |  |    |  ..|| |.    
l....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei..tstl.gekkkthtvkhysykGWiekna

PSDVKQIWQVqsyLRKYTDGHPPVYMSMSGCGRAGTFALFETAHM----SLHN-EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
| . ..| ..   |.  .| .. | .  .| ||. .|.| | ..     ||.. |   |. .. ||..|. |  ....  |..    ..
Pelareilni...lkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv
0048076 (Phosphotyrosine protein) phosphatases II 359-466 7.4e-09 31.0 In-house 38-139 (145) alignment 
Range on Protein: 359-466
Range on HMM: 38-139/145.0
SVSNGTYkTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVY-MSMSGCGRAGTFALFETAHMslhneqPSLNMVKCLENVRNGRLHSVQNLS
|  .. .  ..  ..| .||  ..|.. ......  ..... . . ||.   . |.||.||...    ..       .... ..|| ||. | ..|.| .
selelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpg

QFSVVYTLI
|.  .| ..
qlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 356-464 1.3e-08 30.2 In-house 48-139 (144) alignment 
Range on Protein: 356-464
Range on HMM: 48-139/144.0
KvlsvsngtyktfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD-GHPPVYMSMSGCGRAGTFALFETAHmslhnEQPsLNMVKCLENVRNGRLHSVQ
             .. ... .||  ..|.. ... ..  ..... . |.| .   . |.||.||...    .     ..  |.. ..|. ||. | ..|.
e............giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavp

NLSQFSVVYT
| .|.  .. 
npgqlrfLle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 237-383 2.1e-08 28.1 In-house 89-237 (244) alignment 
Range on Protein: 237-383
Range on HMM: 89-237/244.0
KNHFV-SNMDKNRFVDVICMDHSRVKLTDS----SYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFnkfggNSVFPQNQD
|. |  .|  |||    . .| .|| |. .    .|| | .|  |  . . |||| ||. |. |||.|....... .... .  |      .  .|. . 
kdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep

FLKFE-DRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFiHVHHYKNWPH-GSIP
.  .| |  . . .  .    |  ||.. |  | .....  .    |||  |. |
lewyeeditvtltdrdefknikasnleiesdmneshqal.tmfqisnwpsdgttp
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 256-313 1.1e-07 26.2 In-house 6-61 (130) alignment 
Range on Protein: 256-313
Range on HMM: 6-61/130.0
DHSRVKltDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKcVLLIMTD
. ||..  .  ||.|..| |   ... .||| ||. |. |||.|.... .  ||...  
evsrlq..gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvn.vlvvlgs
subfamily_CG42327_pd Subfamily CG42327 240-389 2.1e-06 21.6 In-house 25-183 (319) alignment 
Range on Protein: 240-389
Range on HMM: 25-183/319.0
FVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF
 |.  ||.|...|. . ..|| |        . |..|..|     .    | .| .|  ..||||... .|. . .. .    |         .| ..  
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYK-NWPHGSIPSDVKQI
   .        .|. | .. . .  | . .   .   .. ||  .|..  .|.. . .
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 266-315 3.1e-06 20.7 In-house 91-143 (349) alignment 
Range on Protein: 266-315
Range on HMM: 91-143/349.0
SYIHANWVDL---NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
 || ||.. |   .  || | || ||  |  ||...|. ...| || .  | |
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke