Gene C46A5.1 in Caenorhabditis elegans

Synonym: CELE_C46A5.1, C46A5.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf16
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP037_AA protein Get Run
CeleP037_AA_202-471 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 197-485 9.9e-187 613.7 In-house 1-294 (303) alignment
Range on Protein: 197-485
Range on HMM: 1-294/303.0
ISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSSYIHANWVDLNSSKKAILTQLPLSHTASDFW
||.||..||||.|..||..||||||||||||..||||..|||.||.||||||||||||.|||.|||.|||||||....|.||||||||||||||||.|||
iseekkqkwkllakrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfw

QMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSD-----VKQIWQ
||||.||.|||||..||.|..|.||.||||.||||||||.|.|||||||.||||.||.|||||||||.||.|.||||||.|||.|||||     ||||||
qmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq

VQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEEQEN
.||.||||.|..|.||||.||||||||||||||||.|||.||.||..|||||||||||||.|||||||||||||.|||||.||| |  . .. |
lqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpn

0040438 (Phosphotyrosine protein) phosphatases II 203-471 3.2e-61 202.7 In-house 3-277 (317) alignment
Range on Protein: 203-471
Range on HMM: 3-277/317.0
TKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNS-SKKAILTQLPLSHTASDF
....|. .  || |...  .|||..  . ....|  ... |.||||..|... |||||||..      |.||.|..||  . ..| |.|| ||..|  ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQ
|.|. .|...... ...  |...      .|. ...|...| .... ....    .|..| .| |.  .. .. .....||..||....|.. .....  
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

SYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
...|..   .|.| . ... |.||.|||.. ..... |. |.  ... .... .|. | ..||...|.  .|....|...
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk

0039614 (Phosphotyrosine protein) phosphatases II 196-471 6.2e-58 191.9 In-house 10-290 (297) alignment
Range on Protein: 196-471
Range on HMM: 10-290/297.0
KISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPhISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLNS--SKKAILTQL
. ....|. . |. . . ... ..  .|||..  . |. .|  ... |.||||..|... |||||||        ||.||.|..||  .  ..| |.|| 
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQDflKFEDRFIRVGEFKQvelGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDV
||..|  |||.|. .|...... ...  | ..    . .|....  ...| .... ....    .|... .|.|.|. .  ......| .||....|...
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

KQIWQVQSYLRKYT----DGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
... ..  ..|..     .|.| . ... |.||.|||..  ...  |. |   ... .... .|. | ..||..||.  .| ...|...
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk

0036941 (Phosphotyrosine protein) phosphatases II 229-474 1e-57 191.1 In-house 25-281 (297) alignment
Range on Protein: 229-474
Range on HMM: 25-281/297.0
GYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVF
 .|....|  ... |..|||. |... ||.||||.|..  ||.|..||. . ..| |.|| ||..|  |||.|. .|...... . .. | ..    . .
llllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqyw

PQN-QDFLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSN--GTYKTFIHVHHYKNWPHGSIPSDVKQ----IWQVQSYLRKYTDGHPPVYMSMSGCGRAGT
| . ...|...| .... ....| | ... | .| |..  . .. .....||..||. ..|.....    |..|...|.....|.| . ... |.||.||
pleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt

FALFETAHMSLHN--EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNG
|.. ..... |..  ... .......  .|. | ..||.|.|.  .| ...|... . 
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl

0043336 (Phosphotyrosine protein) phosphatases II 205-469 2.5e-56 186.5 In-house 7-276 (278) alignment
Range on Protein: 205-469
Range on HMM: 7-276/278.0
WKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQ
.    .| |...  .  .|||..  . ....|  ... |.||||..|... |||||||..      |.||.|..||. . ..| |.|| ||..|  |||.
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

MIIDQKIKCVLLIMTDGEFNKFGGNSVFPqnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYkTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLR
|. ........ .... |... .    .|  ...|...| .... .... .  . ..|.|    .| .  .....||..||....|........   ..|
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavr

KY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
..  ....| . ... |.||.|||.. ..... |..|.  ... .... .|. | ..||..||.  .| ...|.
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley

Y_phosphatase Protein-tyrosine phosphatase 243-468 7.6e-56 184.5 Pfam-A 1-235 (235) alignment
Range on Protein: 243-468
Range on HMM: 1-235/235.0
NMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
|..|||. |....|..||||    ..| ||.||.|..  ..|| |.|| ||..| .|||.|....|.|.. .. .. | ..   .  .| .....|...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RFIRVGeFKQVELGKGWNLKVLSVSNGTYKT---FIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAHMSLHN
 ....   |. |  |...|..|.... . ..    ....||.|||. ..|...|.....   ..|..  . .| | ... |.||.|||.. ... ..|..
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|.  ..........|. | ..||.|.|. ..| .|.|
eee.vdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 243-468 7.6e-56 184.5 In-house 1-235 (235) alignment
Range on Protein: 243-468
Range on HMM: 1-235/235.0
NMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
|..|||. |....|..||||    ..| ||.||.|..  ..|| |.|| ||..| .|||.|....|.|.. .. .. | ..   .  .| .....|...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RFIRVGeFKQVELGKGWNLKVLSVSNGTYKT---FIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAHMSLHN
 ....   |. |  |...|..|.... . ..    ....||.|||. ..|...|.....   ..|..  . .| | ... |.||.|||.. ... ..|..
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

EQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|.  ..........|. | ..||.|.|. ..| .|.|
eee.vdvlqivkelRkqRpgmvqsleqYiflykaile

0050432 (Phosphotyrosine protein) phosphatases II 202-470 1.6e-55 184.0 In-house 9-299 (308) alignment
Range on Protein: 202-470
Range on HMM: 9-299/308.0
LTKWKLVAQETLKDDANIAVNEFEK------------------VSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT-DSSYIHANWVDL---NSSK
|... .. ...|. . .. | .. |                   | . .. .|   .. |.||||..|... |||||||  .|.||.|..||.   ....
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklpr

KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN--QDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN--GTYKTFIHVHHYK
| |.|| ||..|  |||.|. .|.....  ...  | ..      .| .  ...|.... .... . ..    ... . .| ..|  . .  .... ||.
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhyt

NWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|||....|........   ..||. .|.| | ... |.||.|||.. ....  |. |   ... ...  .|  | ..||...|.  .| ...|..
nWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleyl

DSPc_SM00195 224-469 2.8e-55 182.9 In-house 6-261 (263) alignment
Range on Protein: 224-469
Range on HMM: 6-261/263.0
FEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||.  .  | ....... .|..|||. .....||.||||..      |.||.||..... ..|| |.|| ||..| .|||.|....|.|... .. . |
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeee

FNKFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVElgKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--GHPPVYMSM
 .|   .. .|.. ..  .|..  . . | ....  . ..|..|.... .   ........|||||. ..|.. |.. .. ....| ..   .| | .. 
ngkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

SGCGRAGTFALFETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
 |.||.|||.. ...  .|..|.  ... ......|. | ..||.| |....|. |.| 
aGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 224-469 2.8e-55 182.9 In-house 6-261 (263) alignment
Range on Protein: 224-469
Range on HMM: 6-261/263.0
FEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||.  .  | ....... .|..|||. .....||.||||..      |.||.||..... ..|| |.|| ||..| .|||.|....|.|... .. . |
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeee

FNKFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVElgKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--GHPPVYMSM
 .|   .. .|.. ..  .|..  . . | ....  . ..|..|.... .   ........|||||. ..|.. |.. .. ....| ..   .| | .. 
ngkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs

SGCGRAGTFALFETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
 |.||.|||.. ...  .|..|.  ... ......|. | ..||.| |....|. |.| 
aGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey

0045450 (Phosphotyrosine protein) phosphatases II 200-471 4.7e-55 182.8 In-house 9-305 (307) alignment
Range on Protein: 200-471
Range on HMM: 9-305/307.0
EKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPP---HISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLN---------SSKK
....|. |  ...|.|. ..   ||||.  . ..   ..|  ... |.||||..|... ||.||||        ||.||.|..|...         ...|
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS---NGTYKTFIHVHHYKNW
 |.|| ||..|  |||.|. .|...... .... |...      .|.....| ... .... ....    .|. . .| |.      .  .....||..|
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgw

PHGSIPSDVKQIWQ----VQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPS--LNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
|....|...... .    |...|.....|.| . ... |.||.|||..  ..   |..|.    ... .... .|. | ..|||..|.  .| ...|..|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll





0046845 (Phosphotyrosine protein) phosphatases II 223-470 1.6e-54 180.6 In-house 5-274 (284) alignment
Range on Protein: 223-470
Range on HMM: 5-274/284.0
EFEKVSGYLPP---HISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDL------NSSKKAILTQLPLSHTASDFWQMIIDQKIKC
|||..  . ..   ..|  ... |..|||..|... |||||||        ||.||.|..||       ...|| |.|| ||..|  |||.|. .|....
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN---GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--
.  ...  |...      .|.....|...| .... . ..    ... . .|...|   . .  .....||..||. ..|........   ..|.. .  
IVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl

--GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
  |.| | ... |.||.|||.. ....  |..|..   ... ...  .|. | ..||.|.|.  || ...|..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

0051299 (Phosphotyrosine protein) phosphatases II 205-470 1.7e-54 180.6 In-house 10-286 (288) alignment
Range on Protein: 205-470
Range on HMM: 10-286/288.0
WKLVAQETLKDDANIAVNEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFW
.  . ...|... ..  .|||..  .| ....|  ... |..|||..|... |||||||.      .|.||.|...|. |...| |.|| ||..| .|||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

QMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS------NGTYKTFIHVHHYKNWPHGSIPSDVKQIW
.|. .|.....  ...  |...      .|. ...|...| ...  . ..    ... . .| |.       . .. .....||.|||. ..|.......
rmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

QVQSYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
.   ..||.   .|.| | ... |.||.|||.. ..... |..|   ... . .. .|. | ..||...|.  || ...|..
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 220-470 1.9e-51 170.5 In-house 14-272 (273) alignment
Range on Protein: 220-470
Range on HMM: 14-272/273.0
AVNEFEKVSGYLPPHI-SKNHFVSNMDKNRFVDVICMDHSRVKL--TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
   |||..  . |..  |   .. |.||||. |... |||||||   .|.||.|..||. |...| |.|| ||..|  |||.|. .|.....  .... |
lleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve

FNKFGGNSVFPQNQD--FLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN--GTYKTFIHVHHYKNWPHGSIPSDVKQ----IWQVQSYLRKYTDGHPPVY
 ..      .|....  .|.... .... . ..    ... . .| ..|    .. .....||..||  ..|.....    |..|...|... ...| | 
lgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV

MSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
... |.||.|||.. ....  |. |   ... ...  .|. | ..||...|.  .| ...|..
HCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0045098 (Phosphotyrosine protein) phosphatases II 222-471 7.9e-51 168.4 In-house 12-273 (278) alignment
Range on Protein: 222-471
Range on HMM: 12-273/278.0
NEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKltdsSYIHANWVDLNsSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGG
  ..... . |  |. . ...|.||||..|... ||||||     ||.|...|   .|| |.|| || .|..|||.|. ...|.... ...  | ..   
efefllllgipseitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

NSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSV---SNGTYKTFIHVHHYKNWPHGSIPSDV--KQIWQVQSYLRKYT---------------D
   .|  ...| ..| .... ......    . |.|  .    .. .. .....||..|| ...||.   |.....  ..|..                .
aqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

GHPPVYMSMSGCGRAGTFALFETAHMSLhneQPSLNMVKCLENVRNGRLH-SVQNLSQFSVVYTLIAEHVL
|.| .   . |.||.||...  .    |   .. ... .... .|. | . .||||.|.  .| ...|..|
ggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0040439 (Phosphotyrosine protein) phosphatases II 236-471 9.5e-49 161.6 In-house 4-247 (249) alignment
Range on Protein: 236-471
Range on HMM: 4-247/249.0
SKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQn
|  ... |.||||..|... |||||||..      |.||.|...|.  .... |.|| ||..| .|||.|. ...|.... .... |... .    .|. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

QDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT----DGHPPVYMSMSGCGRAGTFALF
...|...| .... ....    ... . .| ..      .  ... .| .||. ..|...... .   ..||.     .|.| . ... |.||.|||.. 
ggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

ETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
 .... |. |.  ...  ... .|. | ..|||..|.  .| ...|..|
ylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallelll

0037934 (Phosphotyrosine protein) phosphatases II 239-468 1.5e-48 160.9 In-house 6-240 (243) alignment
Range on Protein: 239-468
Range on HMM: 6-240/243.0
HFVSNMDKNRFVDVICMDHSRVKLTDSSYIHANWVDLNssKKAILTQLPLSHTASD----FWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPqnQDFlKF
... |..|||. |....||||||| .|.||.||...    .. |.||.||..|  |    ||.|. ...|.... .... | ....    .|  ...  .
llpenlsknrysdilpydhsrvklegsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.ty

EDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK----------YTDGHPPVYMSMSGCGRAGTFALFET
.| .... .... .  . ..|..  .. . .. ... .|| .||....|........  ...|.          . .|.| . . . |.||.||...  .
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl

AHMSLhneqpSLNMVKCLENVRNGRLH-SVQNLSQFSVVYTLIAE
 .. |     .... .... .|. | . .||..||.  .| ...|
mllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle

0042113 (Phosphotyrosine protein) phosphatases II 239-468 1.7e-48 160.5 In-house 5-241 (245) alignment
Range on Protein: 239-468
Range on HMM: 5-241/245.0
HFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDF
 .. |.||||..|... ||.||||.      ||.||.|..||.   ..| |.|| ||..|  |||.|. ...|.... .... |... .    .|. ...
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges

LKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK---YTDGHPPVYMSMSGCGRAGTFALFETAH
|...| .... ....    ... . .|.|.     .. .....|| .||....|......... ...||    ....| . ... |.||.|||..  ...
ltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

MSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
. |. |.  ... .... .|. | ..||..||.  .| ...|
eqlekel.gvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPN12_pd Subfamily PTPN12 242-470 1.5e-36 120.8 In-house 39-277 (290) alignment
Range on Protein: 242-470
Range on HMM: 39-277/290.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF-LK
.|. |||. |..  |.|||.|.      .|.|| ||..   ..|.. | .| ||..| .|||.||...... |...    | .|.  .  .|....  |.
envkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele

FEDrfIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD-GHPPVYMSM-SGCGRAGTFALFETAHMSLHN
|..  ..|   ..  . ... .. | | .   .  ..  ||..||   .|| .|.. .. . .|.. .  . |. .   .|.||.||    . ... |..
fge..fevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka

EQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|.   .|.. . . ..|. |   ||   |...||  .|| |
ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_PTPN1_pd Subfamily PTPN1 236-468 1.3e-32 107.7 In-house 25-269 (290) alignment
Range on Protein: 236-468
Range on HMM: 25-269/290.0
SKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD--
.. .. .| ..||. ||   ||||.||   |  || |. |.|.   .. |||| ||..|.. ||||. .|| |.|...    | ..    . .||...  
reaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

FLKFEDRFIRVgEFKQVELGKGWNLKVLSVSNG-TYK-TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK----YTDGHPPVYMSMSGCGRAGTFALFET
 |..||  ..| .. . |  . . ...| . |  | .   |  .||  ||  ..|.   .  .    .|.     .|  |.|    .| ||.|||.| .|
ellledtklkv.kliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt

AHMSLHNEQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
  . .....   |... | | ..|. ||  .|   |.   |. | |
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPN13_pd Subfamily PTPN13 240-467 1.7e-32 107.8 In-house 34-266 (273) alignment
Range on Protein: 240-467
Range on HMM: 34-266/273.0
FVSNMDKNRFVDVICMDHSRVKLTDSS-YIHANWVDLNSSK---KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKF
  .|.||||. .|. .|..|||| |.. || |... ..  |   ..|..| || .|..|||||. .|| . . .. .. | .|   .  .|....  || 
kkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

EDRfIRVGEFKQVELgKGWNLKVLSVSNGTYKTFIHVHH--YKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMS-MSGCGRAGTFALFETAhMSLHN
..| ..|   |...| .|.... | |..   .  ..| |  . .||  ..||  ... |. ...|.  . . |. .   .| ||.||.   ... . | .
snr.levellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv.lglie

EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
 . .... . ....|. |   ||   |.  ||  | 
rdkefdvkeivrklreqrqgvvqtkdqyifvykail

subfamily_PTPRD_pd Subfamily PTPRD 221-471 2.9e-32 107.1 In-house 26-282 (564) alignment
Range on Protein: 221-471
Range on HMM: 26-282/564.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
 .|..|..     .... .   |  |||. ...  |||||.|       .| || |...|   ..|  | || ||..| .|||.|. .|..... ..   
eeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkl

GEFNKFGGNSVFPQNQdFLKFEDRFIRVGEFKQVELGKGWNLKVlSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMS
 | .|   .. .|...   ....  . . | ....     ..|. . ..   .  ..  |. .||.  .|   ... .. .  |...  | .| |    .
eEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa

GCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
| || |||   .     ...|.  ... ......|. | . ||. .|.. ... |.| . 
GVGRTGtfividamlerikeek.tvDiyqyvkalrkqRnamVqteeQYiFiheaileala

subfamily_PTPN3_pd Subfamily PTPN3 235-466 3.2e-32 106.6 In-house 33-271 (280) alignment
Range on Protein: 235-466
Range on HMM: 33-271/280.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNSSK-----KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
||. .   |..|||. |..  |. ||||..|.  || ||.|....       . | || ||..||.|||||. .||.. .... |  |  .      .|.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

NQDFLKFEDRFIRVGEFkqvELGKGWNLKVLSVSNGTY--KTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSMSGCGRAGTFALFE
..| |.. .  ... .    .  | . |. | ... .   .  |.   | .||  ..|.| ... .. . .||.  |  .| |    .| ||.| . |.|
tedeleygefsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

TAHMsLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
|| . | ... ...... . ..|. |   ||. ||.  |   |
tala.lieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 241-468 1e-31 105.1 In-house 39-274 (281) alignment
Range on Protein: 241-468
Range on HMM: 39-274/281.0
VSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLK
  |. |||.....  |..|||.      ... || ||.|. ... |. | || |. ..  .||||...||.. . ..  . | .|      .|...  ||
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselk

FEDRFIRVGEFKQVELGKGWNLKVlSVSNGTYKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG---HPPVYMSMSGCGRAGTFALFETAHMSLH
. |  ..  . .. .     ..|. . ..|  .. ..  .|..||   .|.. |.. . .. ..|.|.    .| |    .| ||.||.  ....  ...
ygdvtvkstaeeekatyierkfkl.eresgetre.veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave

NEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
.|...|..   ....|. |   || . |.. ||  . .
aeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 222-478 1.3e-31 104.6 In-house 14-278 (285) alignment
Range on Protein: 222-478
Range on HMM: 14-278/285.0
NEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL--TDSSYIHANWVDLNSSKK--AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFN
   .|. ||.||  .   . .| | ||. || |.. .|| |   |  ||||.|. .    .   | || ||  | ||||.|| ..||  ||.. |  |  
lhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg

KFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVEL-GKGWN-LKVLSVSNGTYKTFIHVH-HYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSM-SG
       .|..  . .||    | . | |.  . |  .| | |.   . . . .   | .   ||    | | . . ..  ...|      |. .   .|
vekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsag

CGRAGTFALFETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKK
 ||. ||   . | . .  |.| ..|.  . ..|  |...||.  || ..| .. |...|.|. ..
vgrtatfvgidyatirim.enpniemldivremramrfqavqshmqflflyvvlmeyfigegvver

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 217-470 1.7e-31 103.8 In-house 25-285 (302) alignment
Range on Protein: 217-470
Range on HMM: 25-285/302.0
ANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLN-SSKKAILTQLPLSHTA---SDFWQMIIDQKIKCVLLI
.    .||.|..    .  . . | .|..||.  || ..|. .|||.    ||..|  |..   ... ||.||| . ..    .||.|. ..||. | ..
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

MTDGEFNKfGGNSVFP-QNQDFLKFEDRFIRVGEFKQVELGK-GWNLKVLSvsNGT-YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSY--LRKYTDGHPP
. . | .|   . .|| . .|...... |. .   ...|  |  . . ||   .|     .. | . .||.. ..|  . .. .       .|    .. 
vgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlP..egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadent

VYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| .|. |.||||.|    .|  .|...    |.   ....|. | ..|..|.|.  .|  .. ..
vivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 241-469 1e-30 102.1 In-house 54-289 (298) alignment
Range on Protein: 241-469
Range on HMM: 54-289/298.0
VSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDfLK
 .| .|||. |.| .|.||| |..      | || | ...  . ..| |.|| || .| .|||.|.....|... .. .  | .|   .  .|...   .
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.et

FEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSM-SGCGRAGTFALFETAHMSLH
...  ... . ..       .||| . .. . .. ..  |. .||  ..|.  . . .. .  |...    . || .   .| ||.|||   ..    ..
ygeitvsllskeefadlivrklkvskkkeekere.vrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervk

NEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
.|| .. . . .. .|. | ..||  .|.. .|... | 
keq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_PTPRB_pd Subfamily PTPRB 221-467 3.8e-30 99.9 In-house 28-282 (293) alignment
Range on Protein: 221-467
Range on HMM: 28-282/293.0
VNEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWV-DLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMT
..|.|...       .....   | .|||. ...  |||||||      ..| || ||.. ..|| .. | || || .|  |||.|. ..| . ....  
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltq

DGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQVelgKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT----DGHPPVYM
  |  |   .  .|....   . |  . . . ...   . | .. |...... .. .. .|.. ||   .|.. |.. .    .|...    . .| |  
lvekgkvkCeeYWPadeepvlyGdikvtlvaeeel...edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

SMSGCGRAGTFALFETAHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
  .| ||.|||   ..   .... .  ....  . ..|. | . ||. .|. .... . 
CsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 221-470 1.1e-29 98.5 In-house 26-283 (319) alignment
Range on Protein: 221-470
Range on HMM: 26-283/319.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
 .||.....  . .... .   | .|||. ... .|..||.|.      .| || |...|  .  .| | || ||..| .|||.|. .... .|...  .
ekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

GEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYM-SM
 |  |   . ..|. ..| ..    . . | .. |     .||.   |.      .  ..|..||   .| . ... ..   .|| ...  . |. .   
veklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCs

SGCGRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 | || |||   . | .   .|.  |.. .   ..|  |   ||. .|....|  . | |
aGvGRtGtfivld.amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav

subfamily_PTPN23_pd Subfamily PTPN23 243-469 1.1e-29 98.1 In-house 43-279 (288) alignment
Range on Protein: 243-469
Range on HMM: 43-279/288.0
NMDKNRFVDVICMDHSRVKLTDS--SYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKFEDR
. .|||. |..  ||.|||| .|   || | .|      . . | || ||  |..|||.|. .|| . . ....  | .|   .. .|....   ||.| 
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdl

FIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPS----DVKQIWQVQS-YLRKYTDGHPPVYM-SMSGCGRAGTFALFETAHMSLHN
 . . . .. |     .||.   .. . |.  |. ....||.  .|.     .. . .|.| |  .    . |. .   .| ||.|.|||  .|   |..
svtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelek

EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
..  |.... .. .|. | ..||. .|.  .|  . |.
gnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0049772 (Phosphotyrosine protein) phosphatases II 234-468 1.2e-29 99.4 In-house 37-278 (314) alignment
Range on Protein: 234-468
Range on HMM: 37-278/314.0
HISKNHFVSNMDKNRFVDVICMDhSRVKL-----TDSSYIHANWVDLNssKKAILTQLPLSHTASDF----------WQMIIDQKIKCVLLIM-------
.| .  .. |.||||. |....| .||.|      .|.||.|..||    .| | || ||..|  ||          |.|........  . |       
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------TDGEFNKFggNSVFPQNQDFLKfedrfirvgefkqvelgkgwnlkvlSVS---NGTYKTFIHVHHYkNWPHGSIPsDVKQIWQVQS
                .   ..  |   ......||                         ..    .   .. |..... ..| || | . ......  
delsrLdaAlgKtpllildgng..neptaadlellk.........................eelydpelferlgikylri.pvpDgsap.lledfdefle

YLRKYTDGHPPVYMSMSGCGRAGTFALfeTAHMSLHNeqpSLNMVKCLENVRNGRL-----HSVQNLSQFSVVYTLIAE
..... .|.| .   ..|.||.|||..  .| . ...    ... ..|| ||. |      .....| |.  ..  . |
fieeadkggpvlvHCkaGkgRtgtfvv..aaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 241-469 2.2e-29 97.4 In-house 7-241 (250) alignment
Range on Protein: 241-469
Range on HMM: 7-241/250.0
VSNMDKNRFVDVICMDHSRVKLTDSS------YIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFgGNSVFPQNQDfLK
 .| .|||. |.| .|.||| |  ..      || | ...  . .|  | || ||..|  |||.|....|.. .... .  | .|   .  .| ..   |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ek

FEDrfIRVGEFKQVELGkGWNLKVLSVSNGTYKTF--IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKY---TDGHPPVYMSMSGCGRAGTFALFETAHMS
. |  ..|  ... | .  .  ..| .|. . .    .   |. .||  ..|   . . .... ...    ..  | .    .| ||.|.|   ..    
yGd..vtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

LHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
|..|.  ... | .. .|. | |.|. |.|.. ||..| . 
lkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_PTPN9_pd Subfamily PTPN9 239-470 2.6e-29 97.2 In-house 38-290 (297) alignment
Range on Protein: 239-470
Range on HMM: 38-290/297.0
HFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQD
.  .|. |||. ||.|.|..||.|.       | ||.||.||    ||| | || || .| ||||.|. .|..  ....    |  .   .  .| ....
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees

FLKFEDrfIRVGEFKqVELGKGWNLKVLSVSNGTYKTFIHVHHY--KNWPHGSIPSDVKQIWQVQSYLRKY--------------TDGHPPVYMSM-SGC
  .| |  ..| . . ||  . .. .|| ..| . .   .| |.    ||   .||. ... .| .  |..                  ||. .   .| 
saefgd..lsvsnve.veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRAGTFALFETAHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
||.|||. .. .   |.. .  ...|.... .|. | .|.|   |.   |  . |. 
GrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 206-466 3e-29 96.6 In-house 16-279 (290) alignment
Range on Protein: 206-466
Range on HMM: 16-279/290.0
KLVAQETLKDDANIAVNEFEKVSGYLPPH-ISKNHFVSNM--DKNRFVDVICMDHSRVKLTDS---SYIHANWVDLNsSKKAILTQLPLSHTASDFWQMI
|. .. . |.  ..|.. .||.  ||| . . .. |  |    |||. ||.| | .|| | |     |.|||.|.       |||| .|  |. |.|.|.
kfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl.kamfiltqGalkdtvidiwrmv

IDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ-DFLKFEDRFIRVGEFKQVELG-KGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPSDVKQIWQVQSYLR
...|.  . ..    |  |   .  .|... . | | .  .   | .. .   .   | |  . .|  . . |. . | ||  |..     . ..   ||
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhl.kikswpdksvalstlallrtlrilr

KYTdGhPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
| . | | |    .| ||.|||.  |..   | . . .|....    .|| || |||   |. ..  ..
kas.G.pvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveil

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 209-470 4.4e-27 89.9 In-house 7-277 (307) alignment
Range on Protein: 209-470
Range on HMM: 7-277/307.0
AQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT----DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQK
 |.||.   .  |.||.... . |  .. . | .| ||||. || |.|..|. ..     | |||||.. .    || | .| ||  |  .|| |.|..|
vqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

IKCVLLIMTDGEFNKFGGNSVFPQNQDF-LKF--EDRFIRVGEFKQVELG---KGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPS-DVKQIWQVQSyL
...|...    |  |   .  .| ..   | |  . . | | ..   .|    .  |.  | |  .     |.   ..|||   .|  ..  |  ...  
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea.v

RkyTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|   |  | |    .| ||.||          . . .   .| | .|..|. | ...|.  |.  .. .. |. 
r..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_PTPRA_pd Subfamily PTPRA 213-487 5.1e-27 89.6 In-house 27-311 (330) alignment
Range on Protein: 213-487
Range on HMM: 27-311/330.0
LKDDANIAVNEFEKVSG-YLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKI
  ||..   .||. .    .   .       |..|||.|...  |.||| |.      .| || | ..|    | | | .| |...|  |||.|| .|| 
saddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqks

KCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGT---YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT-
  ....    | ..   .  .|. .  . . .  . | . . ..     .. |  ....|    .  ..  |.. ||.  .|.. . . ..   ..|   
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

-DGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLgNGIGKKDVEEQENSI
  . | |    .| ||.|||  ...    .. |.  ... . ....|. | . || . |.  .|  . |. |  |  . ||   |. .
qsagpivvhcsaGvGrtGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl.ygdteldvsslekhl

0041856 (Phosphotyrosine protein) phosphatases II 243-473 7.6e-27 89.5 In-house 1-174 (182) alignment
Range on Protein: 243-473
Range on HMM: 1-174/182.0
NMDKNRFVDVICMDHSRvkltDSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMtdgefnkfgG----Nsvfpqnqdflkfedr
|.||||..|....||||    |..||.||... .    . |.|| || .|  ||..|. ...|.... .          .                    
nldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............

firvgefkqvelgkgwnlkvlsvsnGTYKTFIHVHHYKNWPHGSIPSdVKQIWQVQSYLRKytDGHPPVYMSMSGCGRAGTFALFEtahM---Slhneqp
                           ..  .. ..| .|| ...|. . .. .     ..  .|.| .   . |.||.||...     .          
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaay...lmkkl......

SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
.... .... ||. | ..|....|. ... .. |..|..
gvsleeavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 222-472 8.2e-27 89.1 In-house 24-282 (318) alignment
Range on Protein: 222-472
Range on HMM: 24-282/318.0
NEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
.|.|..|     .   |     |  |||.....  ||.||||..      | || ||..| . .||| | .| ||..| .|||.|. .|. . ....   
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

GEFNKFGGNSVFPQNQDfLKFEDrfIRVGEFKQVELGKgWNLKVLSVSNGTYKTF--IHVHHYKNWPHGSIPSDVKQIWQVQSYL---RKYTDGHPPVYM
 |  |   .  .|...   ....  ..|   ..|||.. . |. ..|..   .    .. .|| .||  ..|... .. ..        . .. .| |  
eergkakvhryWPskgs.rsygk..lvvelkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
  .| ||.|.|   ..    ...|.  ... .  ...|. |   ||  .|. ..|. . | .  
CsaGvGrtGvfiavdillerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_PTPN14_pd Subfamily PTPN14 223-469 1.3e-26 88.4 In-house 28-295 (300) alignment
Range on Protein: 223-469
Range on HMM: 28-295/300.0
EFEKVSGY-LPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----SSYIHANWVDLNSS---KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
|.|...   .  ..|  .   | .|||| ||.  ...||.|.      . || |  .    .   .. | .| || .|  |||||. .|... ....  .
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee

GEFNKFGGNSVFPQN---QDFLKFEdRFIRVGEFKQ-VELGKGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPSDVKQI----WQVQSYLRKYTDGH--
 |  |    . ||..   .. ..|. .|  . .|..  .      ||.  .  . ..| .|.  |..||   .|.|||.      .|||  || ..    
eedgkeksfkyfPkleskkktvefg.kfkvttkfsedsdsvittglklkhlpskeertvwhl.qytDWpdhgvPeDvkgflsyLeevqsvrrktnseves

----PPVYM-SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
    ||| .    | ||.|   | .    .|.... .... | |. .|. | . ||.|.|.  ||... ..
keskPPvlvhCsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 240-467 3.8e-26 86.8 In-house 44-276 (288) alignment
Range on Protein: 240-467
Range on HMM: 44-276/288.0
FVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFL
   | .|||. ... .|. ||||..      . || |...| . . || | || || .|  |||... ..|.. .. .    | .|   .  .|....  
lavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk

KFEDRFIRVGEFKQVElgkGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSMSGCGRAGTFALFETAHMSLH
.. .  . . | |..|    . |. | .   . .  |. ..|. ||  ..| . ... .. . .    .    | .   . | ||.|||   ...   ..
nyGsvtvtlveskele...dfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidave

NeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
. .  ....  ....|. |   ||.|.|.  .|  ..
e.edyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_CG7180_pd Subfamily CG7180 238-473 7.2e-26 85.5 In-house 37-293 (296) alignment
Range on Protein: 238-473
Range on HMM: 37-293/296.0
NHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQd
..   |..||| |.|.  |. || |.      .| || | .||    ||  | |. |  .|  .||... |..|..|  .   ..|.|   .| .|... 
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.

FLKFEDRFIRVGEFKQVELGKGWNLKVLSV---------SNGTYKTFIHVHHYKNWPH-GSIPSD----VKQIWQVQSYLRKY---TDGHPPVYMSMSGC
  .. . |. . | ||    | ...|.               . .  ... ... |.   ..|.     .. . .|... .|     .  | | .|  | 
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
.|.| .   . | . | ...  ... . .  .|. | . |.|  ..  .| .. |.|| |
sRsGvylaid.anlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 232-470 8.2e-26 85.7 In-house 32-271 (288) alignment
Range on Protein: 232-470
Range on HMM: 32-271/288.0
PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN
 .  . . |..|  ..|. .. . | .||||.| .  ||.|| |  .   .. | .| ||  |   .|.|.... .. ....    |  |   .  || .
asidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

QDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSN-GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAHM
.       |.  |   |.... |  .. .| .|. |  | .. . |...|.. ..| . .   ..   |....  .| | .|  | ||.||..|   |  
lGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq..kPivvhssaGvGrtgtlililiale

SLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
||  .   | . . |.. |. | ...|   |.  |. .. |..
slrldd.flgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Ptp69D_pd Subfamily Ptp69D 214-487 8.3e-26 85.8 In-house 17-302 (307) alignment
Range on Protein: 214-487
Range on HMM: 17-302/307.0
KDDA-NIAVNEFEKVSGY-LPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKI
| |.    ..|.||.     .   .  .   |  |||. |..  |. ||||.      ||.|| |...     .|| |  | |.  |. |||.|| .|..
krdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqev

KCVLLIMTDGEFNKFGGNSVFPQNqDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGT----YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYL-RKY
. . ..   .| |.   .  .|.. |  ...|  ... .... .     .|.|  . . .     .  .  .||..|.   .|   . . .. . .   |
tlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely

TDGHPPVYM-SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLgNGIGKKDVEEQENSI
   . |. .    | ||.|.|  ..     |..|. ......   ..|. |   ||.| |.. .|  ....    |   .||.. |..|
klnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldyss.ygdtdedvddledai

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 198-473 1.8e-25 84.9 In-house 14-295 (319) alignment
Range on Protein: 198-473
Range on HMM: 14-295/319.0
SDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNH--FVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPL
 | .. . .|  .. ..|| ..   || ...   ..   ...     | ||||.....  |...|||        | || | .|.   . .| | .| ||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

SHTASDFWQMIIDQKIKCVLLIMtdgefnKFGGNSVFPQNQDfLKFEDRFIRVgefKQVELGKGWNLKVLSVSN-G--TYKTFIHVHHYKNWPHGSIPS-
  |  |||.|| ....  ..|.       |      .|.. .  | |   ..|   . ||  . . .. . .|. |  . .  |. .|.. ||.   |  
dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkv...dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy

--DVKQIWQVQSYLRKYTDGHPP-VYMSMSGCGRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE-HVLGN
  |. .. .  ..|..  ... . |    .|.||.|..  .. . ..  .|.  ... . ....|. | . ||.| |.  .|. . | |..|.
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld.vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 239-470 4e-25 83.3 In-house 16-264 (270) alignment
Range on Protein: 239-470
Range on HMM: 16-264/270.0
HFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVD--LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD
... .   ||. |..   ..||.| .      . || ||.|    ...|| | .. ||  | ..||.||...| ......    | ..   .  .|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

F-LKFEDRFIRVGEFKQVElGKGWNLKVLSVS-NGTYKTFIHvHHYKNWPHGSIPSDVK----------QIWQVQSYLRKYTDGHPPVYMSMSGCGRAGT
  .|.|| .|.|   ...   .|. |. | .  .|. .  .| ..|..||  ..|..             . .|. . ..  ...| .     | ||.||
ekvkledgkikvlalseek.eegyiltrlrleekgeerrlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FALFETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
. . ..|   |. |. ...... .|..|. |   ||   |.  .|  ..|..
lialDiavrlLe.etkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_PTPN6_pd Subfamily PTPN6 240-470 8.7e-25 82.3 In-house 51-297 (306) alignment
Range on Protein: 240-470
Range on HMM: 51-297/306.0
FVSNMDKNRFVDVICMDHSRVKL-----TDSSYIHANWVD---LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF
 ..|. |||.  .. .||.||.|     ..| || || ..    .|.|. | ||  |..| ||||.|. ... . .... .. | .|      .|.... 
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

LKFEDrfIRVGEFKQvELGKGWNLKVLSVS---NGTYKTFIHVHHYKNWPHGSIPSDVKQI----WQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALF
 .. .  |.| . .. .  . ..|. ||||   ... .  .. .|.|.||  ..|.| ...     .|..  .. .  .  | |    .| || ||| . 
eeyGk..isvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

ETA--HMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
..    .. .  .  ... |. . ||. |   ||  .|.  ||. |....
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

subfamily_PTPRG_pd Subfamily PTPRG 240-482 1.3e-24 81.3 In-house 44-301 (563) alignment
Range on Protein: 240-482
Range on HMM: 44-301/563.0
FVSNMDKNRFVDVICMDHSRVKLT-----DSS--YIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDF
  .|  ||| .... .|.|||||.     ...  || ||..|  . ||. | || || .|. |||.|| .|. . . .|    | ..   .  .|. .. 
kpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.des

LKFEDRFIRVGEFKQVELGKGWNLKVLS--VSNG---TYKTFIHVHHYKNWPHGSIPSD-VKQIWQV-QSYLRKYTDGHPPVYMSMSGCGRAGTFALFET
....   ..  | ... |    .|..    . ..    ..  .  .|| .||  . |.  . ..  | .|   . ..  | |    .| ||.||.  ..|
etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldt

AHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNG--IGKKDVEE
 .  ...|. . |. . |  .|  | . ||.  |.  ..  . | ....   . ...|||
llkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 237-469 2.3e-24 80.9 In-house 22-267 (274) alignment
Range on Protein: 237-469
Range on HMM: 22-267/274.0
KNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
. .   .  |||. ...  ..||| |        ||||| ||..      ||  . || ||..| .|||.||  .... ....    | |.   .  ||.
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

NQDFlKFEDRFIRVG-EFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYL---RKYTDGH--PPVYMSMSGCGRAGTFAL
..|. . ..|.. |  .....   ...... |.... . .  .. . | .||    | |.... ..       |. .. .  | |    .| ||.| |  
aedy.eiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

FETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
 . |   |..|.  ....|   |.|  |   ||. .|. ...  ....
isiavrqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralcly

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 241-473 4.6e-24 80.4 In-house 23-259 (284) alignment
Range on Protein: 241-473
Range on HMM: 23-259/284.0
VSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMtdgefnKFGGNSVFPQNQDfLK
  | ||||.....  |...|||        | || | ..    . .| | || ||  |  |||.|| ....  ..|.       |      .|.. .  |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ik

FEDRFIRVgefKQVELGKGWNLKVLSVSN-G--TYKTFIHVHHYKNWPHGSIPS---DVKQIWQVQSYLRKYTDGHPP-VYMSMSGCGRAGTFALFEtAH
 |   ..|   . ||  . . .. . .|. |  . .  |. .|.. ||.   |    |. .. .  ..|..  ... . |    .|.||.|..  .. . 
eerfkvkv...dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld.vl

MSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE-HVLGN
..  .|.  ... . ....|. | . ||.| |.  .|. . | |..|.
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 243-473 9e-24 79.1 In-house 51-287 (297) alignment
Range on Protein: 243-473
Range on HMM: 51-287/297.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSkKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPqNQDFLKFED
|..|.|. ... .| |||||       || |. | .|  |   . | || |   |  |||.|..|.... ....  | | .|      .. ..   .| |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvttfGd

RFIrvgEFKQVELGKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPS--DVKQIWQVQSYLRKYTDG--HPPVYMSMS-GCGRAGTFALFETAhMSL
  .   . . |.  .|   . |.|..|    . ... ... .||. ...   ..... .. | .||  ..  . |. .  . | ||.| .   .   .. 
vsv...vllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv.vae

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
 ... .... . .. .|. | . ||   |.. || .. | .| .
akrekevdifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 222-480 1.6e-23 77.8 In-house 15-275 (281) alignment
Range on Protein: 222-480
Range on HMM: 15-275/281.0
NEFEKVSGYLPPHIS--KNHFVSNmDKNRFVDVICMDHSRVKLTD-------SSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIM
.|| .. |  |  .    |. | |  |||.... |.| |||.|         . |||||..     |.  |||| |   | .|||.|| ...  ..... 
qefsnlpgdppsdlctvfnqpvnn.kknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

TDGEFNKFGGNSVFPQNQDFLKFEDRFIRvgEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKytDGHPPVYMSMS
   | |.      ||.|       |..    ....  . |      | .|      .|    .|.||   .|   . . ..   .|      |||    .
qfletnrekcaeyfprnahcclqfdklsv..syedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira..rstppvihcsa

GCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVR-NGRLHSVQNLSQFSVVYTLIaehvLGNGIGKKDV
| ||.||.   | |  |.|.     .. . .  .|  ||  ||| | |. ... ..    |  |.  |..
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl....ldfgvaykqi

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 241-472 3.2e-23 77.3 In-house 46-290 (325) alignment
Range on Protein: 241-472
Range on HMM: 46-290/325.0
VSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKAIL-TQLPLSHTASDFWQMIIDQKiKCVLLIMTDGEFNKFGGNSVFPQN----Q
  |..|||| .|. .|.||| |       .| || |...  .  |.  | .| ||..|  |.|....| .   |....   . .|      .|..    .
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksk

DFLKFEDRFIRVGEFkqvELGKGWNLKVLSVSNGTYKTfIHVHHYKNWP-------HGSIPSDVKQIWQVQSYLRKYTDGHPPVYM-SMSGCGRAGTFAL
 |  .| ... . |.          |.|  |..|  .. ..  ... |.         .. | .. . .|.  ..  | .  |. .  ..| ||.|.|. 
tfGglevklrtieei...sdyvhrvldvkqvkkGetrs.vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

FETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
. .|   .  |. .... . ....|. |   |.   |....|. ..| .. 
lysalakvi.eesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 221-470 1.1e-22 75.6 In-house 25-283 (305) alignment
Range on Protein: 221-470
Range on HMM: 25-283/305.0
VNEFEKVSGYlPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
 ......    .  |  ..   |  |||..... .|..|..||      || || |..||   ..|| |..| || .| .|||..|.. |.. ....   
eaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltkl

GEFNKFGGNSVFPQNQDF-LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG---HPPVYMS
 | .|   .  .|...    .|..  . . ..|...     .||.   ..   .  .  ..  .||   .|     . ..   ..|        | .   
veggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC

MSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
  | ||.|.|   . |   |..|. .... . | ..|. |.  ||.| |.  ..  ..| .
sagvgRtGvfiavdialerlkkEe.vvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 235-468 3.1e-22 73.8 In-house 38-281 (290) alignment
Range on Protein: 235-468
Range on HMM: 38-281/290.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLT------D--SSYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVF
.  .   ||  .||| ...  |  |. |       |   .||.| ...  . .|. |.|| |.|.|. |||..| ..|. .......  | .|   .  .
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW

PQNqDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWP-HGSIPSDVKQIWQVQSYLR-KYTDGHPPVYMSMSG-CGRAGTFALF
|.. |  ...   |.. . ....     .|.| . ... .|. .. .. .||. .|...     . ...   . .. .|  .. .  |.  ||...|   
pds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaa

ETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
.|.    . |.   .... |.. |  .  |||   |. ...... .
attinkckteg.vidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

subfamily_PTPRK_pd Subfamily PTPRK 242-471 3.4e-22 73.7 In-house 42-278 (314) alignment
Range on Protein: 242-471
Range on HMM: 42-278/314.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFlkF
 | .|||. |.. .|.|||.|.      .| || |...|  . ... | || || .|  |||... |..  .....    |  ..     .|.. .   .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..y

EDrfIRVgEFKQVELGKGWNLKVLSVSN--GTYK--TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAhMS
.|  |.| |. ..|| .    ....|..   ...    ..  .. .||.  .|   . . ..   . | .  .  . |   ..|.||.|||   ..  . 
gd..ikv.elvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv.ld

LHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
. ...  ... ..  ..|. .   |.   |.  .|  | | .|
mieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 223-470 4.7e-22 73.3 In-house 29-280 (315) alignment
Range on Protein: 223-470
Range on HMM: 29-280/315.0
EFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
..| . |     .   . . | .|||....| .|.|||.|       .| |. ||..|  |  .. | .| |.  .  |||... ...|  ....    |
dyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlve

FNKFGGNSVFPQNqdFLKFEDrfIRVGeFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGH--PPVYMSMSGC
 .|   .  .| .   . .    | |   |. |  . .  . |||  |     .   ||  ||   .|     . ..    ... .    . |    .| 
gekrkaekywpdk..kviyGk..itvt.rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGv

GRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH-V
||.|||  ...    .. |.  ... . ...||. | . || . |.  .|  . |  |
GrtGtfitldavldqaeaen.aidvynfitgvrqnrikmvqvaeqyqfiydalletfv

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 220-470 5.1e-22 72.9 In-house 26-289 (305) alignment
Range on Protein: 220-470
Range on HMM: 26-289/305.0
AVNEFEKVSGYLPPHISKNHFVSN------MDKNRFVDVICMDHSRVKLTD---SSYIHANWVD--LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVL
  .|| ... |  | .... | .|      . |||. || | |.| ||| .   | |||||.|   .   |. | .| || .|  .|| |.|..|.. ..
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqiv

LIMTDGEFNKFGGNSVFPQNQDF---LKFEDRFIRVGEFKQVELGKGWNLKVLSVSN-GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHP
..    |  |.     .|  |     ||       |   | .|     .. .| ..  |  |  .   .. .||   .|       .. | .|      |
mlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk..vp

PVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 |    .| ||.||    |     . ...|   | . .  .|. | .|.||  |.  .. .. ...
ivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 242-482 1.3e-21 71.7 In-house 47-299 (305) alignment
Range on Protein: 242-482
Range on HMM: 47-299/305.0
SNMDKNRFVDVICMDHSRVKLTDS---SYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
 . .|||. || |.|. ||||  .    |||||.|   . .|. | || || .| .||| | ...|.. ....    |         |. ...| |.||.
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

RFI----RVGEFKQVELGKGWNLKVL----SV-SNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYtDGhPPVYMSMSGCGRAGTFALFETAHM
.      ..   ..... |  . ||      .   |. .  .  .|. .||   .|.    | ..    |    | | |    .| ||.|.  ..|    
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.kg.pivvhcsagigrtgsvvmleyild

SLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEE
 | . |   .  | |  .|. |  |.|   |.  |. .| .... ... ...|.|
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevke

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 235-470 2.8e-21 70.8 In-house 39-278 (287) alignment
Range on Protein: 235-470
Range on HMM: 39-278/287.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLTD--SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDf
.  |   .| ||||. ...  |  || | .    || | ..|  ..||| |... |...|| .||..| |.... ....  . | ..      .|...  
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWP-HGSIPSDVKQIWQVQSYLR-KYTDGHPPVYMSMS-GCGRAGTFALFETAHMS
. . .  |.. . .. .     .|.|   .. . |  .. ... ||. .| ...    . ...   . ..  |. .. .  | . ||...|   .|.   
vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink

LHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 ..|   ..... |.. |  . .|||  .|.  .. .. |..
ckte.GviDvfqvlksqriqkpgsvqtveqykfindivleyl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 240-471 7.3e-21 69.3 In-house 41-278 (315) alignment
Range on Protein: 240-471
Range on HMM: 41-278/315.0
FVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ-NQDF
   |. |||. ... .|..||||       || || |  .    . |  | .| ||  . .|||.|....|.  . ..    | .|   .  .|. . | 
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

LKFEDrfIRVGEFKQVELGKGWNLKVlSVSNGTYKTFIHVHHYKNWPHGSIP----SDVKQIWQVQSYlrKYTDGHPPVYMSMSGCGRAGTFALFETAhM
 .|    |.|  ..    . | . |.  . ..  .  .  .....||.  ..    | .| | .|..   . .. .. .   ..| ||.| .   .   .
vefGs..ikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidev.v

SLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
.  ... |... . ..|.|. | . ||   ... .|  . |..|
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_PTPRN_pd Subfamily PTPRN 238-470 8.3e-21 69.0 In-house 51-292 (297) alignment
Range on Protein: 238-470
Range on HMM: 51-292/297.0
NHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA--ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ
 .   |..|||  .|.  |||||||..      | || |  .  .  ...  | || ||..| .|||||. .| .  .. . .  | .    .  .|.. 
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG

DF--LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGtyKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGH--PPVYMSMSGCGRAGTFALFETA
      .| ...    . .  | . . || |  |.   .| .   |.  ||. ..|.  | . . .  . |   |   | |  ...|.||.|.. | .  
sevyhiyevhlvsehiwcddylvrsfylknlqtset..rt.vtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv

HMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
   | .    ....  || .|. | . |.  .|| ...| .|| |
lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 242-471 8.3e-21 68.6 In-house 42-277 (515) alignment
Range on Protein: 242-471
Range on HMM: 42-277/515.0
SNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ-NQDFLK
 |  |||. ... .| .||||       .| |. |  .   .. |  | .| |.  . .|||........  . ..    | .|      .|.   | .|
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

FEDrfIRVGEFKQVELGKGWNLKVLSVSNGTYKTfIHVHHYKNWPHGSIPS----DVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAhMSL
|    |.|        . |   |.  . .  ..| .  .|...||.  .|      .| | .|..   .||  || .   ..| ||.| .   .   .. 
fGs..ikvelvsleactggikrkltvlkgddsrt.vtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsv.vah

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
 ..  .... . ..|.|. | . ||   |.. .|  . |..|
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

0046846 (Phosphotyrosine protein) phosphatases II 263-467 2.4e-20 68.5 In-house 10-170 (176) alignment
Range on Protein: 263-467
Range on HMM: 10-170/176.0
TDSSYIHANWVDLNsskKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKfedrfirvgefkqvelgkgwnlkvlsvsn
 |..||.||... .   . | || || .|  ||..|. ...|..|. .... |.....    .|. ...                               
ldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

gtyktfihVHHYKNWPHGSIPSDvKQIWQVQSYLRKYTDGHPPVY-MSMSGCGRAGTFALFEtahmsLHNEQPSLNMVKCLENVRNGRL-HSVQNLSQFS
         ... .|| ...|.. ......  ..|.. . . ||.   . |.||.||...       |   .  |.. ..|. ||. |  ..||. .|  
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqtpeQyr

VVYTLIA
 .|  . 
flyefel

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 214-470 3.9e-20 66.7 In-house 16-279 (439) alignment
Range on Protein: 214-470
Range on HMM: 16-279/439.0
KDDANIAVNEFEKVSGYLPPHISKNHFVS---NMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQK
|.. .|  ..|||..   |..  .  ...   .  |||. ||  .||.|| |        | || ||...     |  | || |  .|. |||...|..|
knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

ikCVLLIMTDGEFNKFGgnsVFPQNQDFLkFEDRFIRVGefKQVELGK--GWNLKVLSVSNGTYK-TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT
  .| ..|    .. .     .| ...   . |  .||   ...|| .     .||.   . | |   .   ||  ||.  .|..   . .    .    
..tvtivmltnlvesyk...ywpsdaevc.ygdiavrvd..rnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

D---GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|     | |    .| ||.||   .. |   |. |.  ...   .. .|. | . ||.| |. ..|  . | .
dkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 234-463 4e-20 66.7 In-house 41-279 (301) alignment
Range on Protein: 234-463
Range on HMM: 41-279/301.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS---YIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN-
|| . .   . ||.|.  | |  .. |.. .      |||||.. .  ... | || ||. |. ||| |..  ... . ..    | ..   .. .|.. 
hitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

QDFLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSNGTYK----TFIHvHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFET
.. |. .   |.. . ... | |  . . | | . | |    | .| . |..|..  .|    .....   ..|    .| |    .| ||. .|   | 
sekldigrfkikiknkeli.lnkkiskrtlevedstgkfatrtvth.yqysewtdrgvPkshaelfdlmelvkkse..kPivvhcsaGiGrsvafigtey

AHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFS-----VVY
    ... .| ... . |...|. | ..||. ||.       ||
larevea.dptieltealkhlrehrwngvqtnsqlywmtlGtvy

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 234-470 1.7e-19 64.9 In-house 24-259 (267) alignment
Range on Protein: 234-470
Range on HMM: 24-259/267.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLTDS--SYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfgGNSVFPQNQD
 ||.     | ..||. |..  |..|| | ..   || | .|.    |.| |.|| ||. | .||...|.|||.  . |... .. |        |.  .
tisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni..rlfwPPkmgq

FLKFEDRFIRVGEFKQVELGKGWNLKvLSVSNGTYKtFIHVHHYKNWPHGSI-PSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSL
  |..|  .     |. .  .   |. | . | . .  . ...||.|   .     .| .. . .  .    ..| |     | ||.|||   ..    .
akkyqdltvehslekeendyqiitle.lkfknesah.nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

HNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
 .|.  ... . | ..|. |   |. . ..  .. |.||. 
kteg.vsdifdflrkirsqriglvdtkeryiyihellaeya

0043147 (Phosphotyrosine protein) phosphatases II 264-463 2.7e-19 65.0 In-house 4-154 (172) alignment
Range on Protein: 264-463
Range on HMM: 4-154/172.0
DSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDgefnkfggnsvfpqnqdflkfedrfirvgefkqvelgkgwnlkvlSVSN
.| ||.|...||.    . | || ||..| .|||.|. ...|.... ...                                               .  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

GTYKTFIHVHHYKNWPHGSIPsDVKQIWQVQSYLRK---YTDGHPPVYMSMSGCGRAGTFALFETAHmslhneqPSLNMVKCLENVRNGRLHSVQNLSQF
  .. ..  ..| .|| .. | . ...... .....     .|.| .   . |.||.||...    .        .|.. .... ||. | ..||| || 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy

SVVY
  .|
rfly

0051429 (Phosphotyrosine protein) phosphatases II 264-469 4.4e-19 64.6 In-house 3-224 (272) alignment
Range on Protein: 264-469
Range on HMM: 3-224/272.0
DSSYIHANWVDLNSS----KKAILTQLPLSHTASDFWQMiIDQKIKCVLLIMTDGEFNKFGGNSVFP-----------QNQDFLKFEDRFIRVGEFKQVE
 |.||.|..|. . .    .. .... || .|| |||..  ...||... .... | ....   . |               .  . . .... .... .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVkqIWQVQSYLRKytdGHPPVYMSMSGCGRAGTFALFETAHmSLHNEQPSLN--------MVK
    ..| .  ... .    ... || .||  ..|..   . .. ..|..   |.| ..  ..|..| ||...         ...  ..        . .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlylee

CLENVRNGRLHSVQNLSQFSVVYTLIAEH
..| .|  | ..||.  |.  .|  ..| 
aveelraqrpgavqteeqylflyeallel

PTPc_DSPc_SM00012 369-468 4.7e-19 63.9 In-house 2-105 (105) alignment
Range on Protein: 369-468
Range on HMM: 2-105/105.0
IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD----GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYT
... ||..||. ..|.... | ..  ...| .     ..| | ..  |.||.|||.........|..|. .... .... .|. | ..||.. |....|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LIAE
 ..|
alle

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 221-312 3.8e-18 60.1 In-house 30-127 (310) alignment
Range on Protein: 221-312
Range on HMM: 30-127/310.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT-D----SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMT
|... |.     . .. . .  .| |||. ||.|.| |||||. |      |||||.|  |  ... | .| || ||  |||.||.... . .||.  
vkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 234-483 4.1e-18 60.1 In-house 34-289 (312) alignment
Range on Protein: 234-483
Range on HMM: 34-289/312.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD
      |.   | ||. .. | |  |  |.  .  |||||.| . .  .  . || ||  |.. |||. .     ...|. .  |           .   
dsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg

FLKFEDRFIRVGEFKQVELGKGW-------NLKVLSVSNGTYKTFIHvHHYKNWPHGSIPSDVKQIWQVQSYLRKytDGHPPVYMSMSGCGRAGTFALFE
|...||  .      ..|.|           |||.  . |    . | . .  ||   .|  .    .. | ..|  | .| .    .| ||.||.|| |
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnh.yqwaswpdhgmpdscdtalrllsavkk..dkkpviahcsagvgrtgtlalie

TAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEEQ
.   .|   .   |. . .  .|. |  ||. . |.  .   . | .  .|. |.. .| 
smiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqew

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 240-471 2.2e-17 57.6 In-house 42-237 (392) alignment
Range on Protein: 240-471
Range on HMM: 42-237/392.0
FVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWV-DLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMT--DGEfnkfggnsvfpqnqd
   |. |||. ... .| .||||      .|| |. | ..  ... |  | .| | . . .|||.|. ....  . ..    .|.               
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

flkfedrfirvgefkqvelgkgwnlkvlsvsNGTYKTFIHVHHYKNWPHGSIP----SDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAH
                               .|  .  .  .|. .||   .|    | .| | .|..   .||  || .    .| ||.|     ..  
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..hpliihcsagvgrtgvvisidsvv

mSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
 .  ..   ..... . |.|. | . ||   |....|  . | .|
.ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 211-468 7.4e-17 56.0 In-house 6-275 (287) alignment
Range on Protein: 211-468
Range on HMM: 6-275/287.0
ETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----SSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKI
   ||| .  |. . . |   .    . . . .. |||. ||. .|..|| |.      |.|| ||.|   .  .. | .| |.. |  |||....... 
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrs

KCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVgeFKQVELGKGWNLKVLSVSNGTYK--TFIHVHHYKNWPHGSIPSD----VKQIWQVQ---SY
  |...  . |  .      .|...  ..     . .  ...  .   .  . | . .   .    ..  .. .|| ....      .. . .|.     
asvitmtreveearlkcykywPerevPmrvGGysvvl..ldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

LRKYTDGHPPVYMSMSGCGRAGTFaLFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
 |. ..  |.|     | ||.|.. |   . .|  ..   ... . .  .|. |   ||   |. ..|  .. 
ardasevGPlvvhddvGiGrsGil.latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 219-472 3e-16 54.2 In-house 10-268 (283) alignment
Range on Protein: 219-472
Range on HMM: 10-268/283.0
IAVNEFEKVSgyLPPH-ISKNHFVSNMDKNRFVDVICMDHSRVKLTDS--SYIHANWVD----LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIM
.  . ....|  .|.     .    |  |||. ... .|  ||.|     .|| | ..      . .|| | .| || .|  |||.|. |.|| ..... 
lfrevlkrls..vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

TDGEFNKFGGNSVFPQNQdFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSNG-TYKTFIHVHHYK--NWPHGSIPSDVK---QIWQVQSYLRKYTDGhpP
   | ..      .|..    .. .  . . .       . .  | | . .  . |. . . ||.  .| . .  . .    .. .|.|  ..  .|  |
klqedlrikCsqyWPkrG.sedyGeftvtlrkett...snsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg..P

VYMSM-SGCGRAGTFALFETAhMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
. .   .| ||...|    .. .     .  ... . ....|. |   ||.| |. .|..|. |. | 
ivvhCstgiGrtavfiaasas.vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc

0036282 (Phosphotyrosine protein) phosphatases II 265-463 1e-15 53.3 In-house 2-163 (174) alignment
Range on Protein: 265-463
Range on HMM: 2-163/174.0
SSYIHANWVDLNS-SKKAILTQLPLShtasdFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnqdflkfedrfirvgefkqvelgkgwnlkvlsvSNG
|.||.|...||.  ... |..| ||.     ||.|. ...|..|.  ..  | ....    .|                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

TYKTFIHVHHYKNWPHGSIPSDVKqIWQVQSYLRKY---TDGHPPVYMSMSGCGRAGTFALFETAHMSLHneQPSLNMVKCLENVRNGRLHSVQNLSQFS
 .. ... ..| .|| .. |.. . .... ......    .|.| .   . |.||.||...    .. |.  ..  . .. .  .|. | ..||. ||. 
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

VVY
 .|
fly

0049260 (Phosphotyrosine protein) phosphatases II 278-463 1.1e-15 53.1 In-house 8-143 (152) alignment
Range on Protein: 278-463
Range on HMM: 8-143/152.0
SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFpqnqdflkfedrfirvgefkqvelgkgwnlkvlsvsngtyktfihVHHYKNW
....| || |...|..|||.|. ...|.... .... |..|.. .  .                                              ... .|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

PHGSIPSDVKQIWQVQSYLRK--YTDGHPPVYMSMSGCGRAGTFALFETAHmslhneqPSLNMVKCLENVRNGRLHSVQNLSQFSVVY
| .. |..   . ..   ..|    .|.| .   . |.||.||...    .         ... .... ||. | ..|.| .|   .|
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 243-464 8.6e-15 49.5 In-house 7-234 (239) alignment
Range on Protein: 243-464
Range on HMM: 7-234/239.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWV-DLNSSKKA-ILTQLPLSHTASDFWQMIIdQKIKCVLLIMTD-GEFNKFGGNSVFPQNQDflK
|  |||. ...  ||||| |        | || |... | . | || | ||  .. .. |||.|.  |. .||....|   |  |      .|..    |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmw.qerrcvivmltglieghkkkchqywpdsts..k

FEDrfIRVGeFKQVELGKGWNLK--VLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFEtAHMSL
. .  .||  ... |.   . ..  |.|    | . ... .|.  ||   .|     .  ..  . | .    .| |    .| ||.|.| . . | .  
ycn..lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid.amlrq

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYT
 ..| ...... .. .|. | | ||   |. ... 
akkqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 243-463 9.3e-15 49.4 In-house 8-234 (239) alignment
Range on Protein: 243-463
Range on HMM: 8-234/239.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWV-DLNSSKKA-ILTQLPLSHTASDFWQMIIdQKIKCVLLIMTD-GEFNKFGGNSVFPQNQDflK
|  |||. ...  ||||| |        | || |... | . | || | ||  .. .. |||.|.  |. .||....|   |  |      .|..    |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmw.qerrcvivmltglieghkkkchqywpdsts..k

FEDrfIRVGeFKQVELGKGWNLK--VLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFEtAHMSL
. .  .||  ... |.   . ..  |.|    | . ... .|.  ||   .|     .  ..  . | .    .| |    .| ||.|.| . . | .  
ycn..lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid.amlrq

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVY
 ..| ...... .. .|. | | ||   |. ...
akkqktvdifnyvkairedrphmvqtseqyvfih

subfamily_egg_pd Subfamily egg 242-473 6.8e-14 46.2 In-house 39-276 (307) alignment
Range on Protein: 242-473
Range on HMM: 39-276/307.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfgGNSVFPQN-QDFLK
 |..| |   | | | |||||          .|||| |. .    . ||.| ||  |  |||.|.  .... .... .  | ..   .  .|.  .| |.
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser..ceyywpkaesdslv

FEDRFIRVGEFKQVELGK-GWNLKVLSVsNGTYKTFIHVHHYKnWPHgSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAHMSLHNE
.    .|.  .|  .     ...  | .  |. .   .. |.. .      |||    .|   ||. .  .| |  .. |. .|.|.   |.| .||   
tvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwq.gdv.nnssdvysplrvlrklrnls..kpvvvqdilGvskaatlvaieiallsllrG

qPSL--NMVKCLENVRNGRLHSVQNLSQFSVVYTLIA---EHVLGN
 |     . ..   .|  |  ||.   ..  || |..     |.|.
.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs

0044763 (Phosphotyrosine protein) phosphatases II 256-466 7.5e-14 47.2 In-house 3-167 (178) alignment
Range on Protein: 256-466
Range on HMM: 3-167/178.0
DHSRVKLT------DSSYIHANWVDLNsskkAILTQLPLshtaSDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDflkfedrfirvgefkqvel
|..||.|.       | ||.|.... .     .|..||     .|..... ...|.... . .. | .... .  .|.. .                   
drtrvllsnleglersdyinaseilpg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................

gkgwnlkvlsvsngtyktfIHVHHYkNWPHGSIPSDVKQIWQVQSYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSlhneqpSLNMVKCLENVRN
                   |...|. ..| .. |.  ......  .....  ..|.| .   . | ||.||...    ..       .|.. ...| ||.
...................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvre

GRLhSVQNLSQFSVVYTLI
 |   |.| .|   .| . 
rRp.ivpnpgqlrqLyefe

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 258-481 1e-13 44.6 In-house 91-320 (346) alignment
Range on Protein: 258-481
Range on HMM: 91-320/346.0
SRVKLTDSSYIHA---NWVDLNSSKKAILTQLPLSHTA---SDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQDFLKF-EDRFIRVGEFKQVELG
||   .  .|.|     .| ..  .| |..|||  .      ||| || ...|. | |.. |  ...    |.| ...   ..    ||           
srrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkn.tttslfndenggyqytgkmfinnrradvsgdp

KGWNLKVLSVSNGTyKTFIHVHHYKNWPHGSIPSD----VKQIWQVQSYlrKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVR
| . ..||   |       .|||.  | |   |      .| | |  |   |         .|. ||||| .|     |   | |     |... . |..
keytievlpegnsd.svicqvhhhapwkhlqqppktlpiikmihqflse..kqvqnagvcvvslfgcgracsfigalyainqlnng.iepniceimknik

NGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVE
. |  .|. ..|.. .|... ...     |||.  
qqrpggvesfaqyasiyaivfdyiarkrggkkapv

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 243-466 1.6e-13 45.4 In-house 3-235 (237) alignment
Range on Protein: 243-466
Range on HMM: 3-235/237.0
NMDKNRFVDVICMDHSRVKLT----DSSYIHANWVDL--NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFED
|  |||. .....||||| |     .| || |....    . || | .| ||  .  |||||. ..|   ....    | |.      .|. ..   .  
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

rfIRVGEFKQVELGKgWNLKVL-SVSNGTYK--TFIHVHHYKNWPHGSIPSDVKQIWQVQSYL----RKYTDGHPPVYMSMSGCGRAGTFALFEtAHMSL
  . |   |. |.   . .. |  . ..| |   .|| ...  ||.  .|     . . .  .    .. ..  | .    .| ||.| | . . | .  
..ltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid.amlrq

HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
 .|.  ... . . .. . | . .|   |. ...  |
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti

0051082 (Phosphotyrosine protein) phosphatases II 265-465 2.7e-13 45.3 In-house 3-148 (151) alignment
Range on Protein: 265-465
Range on HMM: 3-148/151.0
SSYIHANWVDLNsskkAILTQLPLShtasDFWQMIIDQKIKCVLLIMTDGEFNkfGGNSVFPQNQdflkfedrfirvgefkqvelgkgwnlkvlsvsngt
|.||....|. .     .... ||.    ||.... ...||... .... | .     . .|...                                   
sdyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

ykTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKyTDGHPPVYMSMSGCGRAGTFALFETAHMSlhneqpsLNMVKCLENVRNGRLHSVQNLSQFSVVYT
    ..  .. .||  ..|   ... .. ..|.. ....| .   ..|.|| ||...    ..        ... ..|| .|  | ..||   || ... 
..ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlf

L
 
a

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 235-393 4.7e-12 40.4 In-house 25-190 (297) alignment
Range on Protein: 235-393
Range on HMM: 25-190/297.0
ISKNHFVSNMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN---SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
 |  .  | . |||. |.. .| .||||    |.. || |..| .    .  | ||.| ||| |  |||... .| .. . ..    |  .      .|.
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps

NQ-DFLKFEDRFIR-----VGEFKQVELgkgWNLKVLSVsnGTYKTFIHVhHYKNWPHGSIPSDVKQIWQVQ
 . . ||  |  .        ||..| |    .|...       .   ||  . .||   .|||.... . |
vvqerlkagdvvveflsstsdefdrvil...telqliyr..sesrvvrhv.qflswpdhGvpsdledlvrfq

subfamily_ptpA1_pd Subfamily ptpA1 234-322 7.7e-12 39.7 In-house 38-132 (418) alignment
Range on Protein: 234-322
Range on HMM: 38-132/418.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGN
  |.     |  |||. ... ..|.||.|        | || ||..|    |. | || ||  | .|||.|. ... . ....  . |  .   .
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 263-464 1.2e-11 39.3 In-house 44-253 (290) alignment
Range on Protein: 263-464
Range on HMM: 44-253/290.0
TDSSYIHANWVDLNSSKKAILTQLPLSHT-------ASDFWQMIIDQKIKCVLLIMTDGEFNK----FGGNSVFPQNQD-FLKFEDRFIRVgefKQVELG
  . ||||| |   .  . |||| |. ..         .|| |. . |.| |  .    | ..    |  .  .|.. .  |||..  ..    |. |  
fnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC...kskeke

KGWNLKVLSVSNGTYKTFIHVHH-YKNWPHGSIPSDVKQIWQVQSYLRkyTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGR
.. . . | |  .  . |   |. .|.| . ... | | . .. ....  . . | .   . |  |  ..|  . .   . . . |..... |...|. |
ddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr

LHSVQNLSQFSVVYT
 . ...  ... |  
alaitsalelafvda

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 237-310 7.7e-11 36.0 In-house 28-107 (332) alignment
Range on Protein: 237-310
Range on HMM: 28-107/332.0
KNHFVSNMDKNRFVDVICMDHSRVKLTD----SSYIHANWVDLNSSKKA-ILTQLPLS-HTASDFWQMIIDQKIKCVLLI
 ..|. ||| ||   . |.|||||.|.       .  |.|||  | | | |..| |.  ||   ||.|. ..|   .|..
ydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 236-467 1.1e-10 35.8 In-house 44-290 (301) alignment
Range on Protein: 236-467
Range on HMM: 44-290/301.0
SKNHFVSNMDKNRFvdvICMDHSRVKLTDSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ----D
.... ....|.||.   |   .....|.  .|| |...|  |. || | .| |. .|  |||..|...|   .. ..   |  |   .  .|. .    .
nrfknitvyddnri...ilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

FLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSN-GTYKTFIHV-----------HHYKNWPHGSIPSDVKQIWQVQS--YLRKYTDGHPPVYMSMS-GCGR
| .|.  ..    . .  . .  |.|.  .|| |  .  ..|            .  .||.  .  . . . ||      |.   |  ||    | . .|
fgpftvtlvneqvyPdf.virqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsr

AGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
.|..   . .      |    ....  . ||  .   |. | |.. .|  | 
sGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvid

subfamily_eak_pd Subfamily eak 203-376 1.7e-10 34.8 In-house 11-186 (332) alignment
Range on Protein: 203-376
Range on HMM: 11-186/332.0
TKWKLVAQETLKDDANIAVNEFEKVSGYLPP-HISKNHFVSNMDKNrFVDVICMDHSRVKLTDS-----SYIHANWVDLNS-SKKAILTQLPLSHTASDF
 || |. .. . .  |  .|  ...  | .   ||.   . ....|  |...  |.  |.|| |      || |  ....   .| ||| ..       |
ekwilinknhiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfaf

WQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ-DFLKFEDRFIRVGEFkqVELGKgWNLKVLS--VSNGTYKtfihVHHYKN
|||...||  ... .. | | .    .  ||..  . |||    .   ||  |. ..  . . |   . | |..    |.||| 
wqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrni.letrllelskGnethr....vlhykv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 241-317 1.8e-10 35.1 In-house 45-142 (350) alignment
Range on Protein: 241-317
Range on HMM: 45-142/350.0
VSNMDKNRFVDVICMDHSRVKLT--------------DSSYIHANWVDLN-------SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFN
|  . |||.....  .||||||                . || ||.. |.       .. | | || ||  |  ||...|.  |.| .| . .| |.|
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 224-311 1.5e-09 31.9 In-house 18-117 (347) alignment
Range on Protein: 224-311
Range on HMM: 18-117/347.0
FEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----------SSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIM
 |....| |.... . .  ...|||  ||  .| .|| |.             .|| |  . . |.||. |||| || .|  |||.|.   |.  |. |.
denlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif





subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 286-466 7.4e-09 30.0 In-house 39-217 (255) alignment
Range on Protein: 286-466
Range on HMM: 39-217/255.0
LplshTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKFEDRFIRVGEFKQVELGKGWNLkvLSVSnGTYKTFIHV--HHYKNWPHGSI
|    |   |.|.|. .| . | ..    | ..   .| || ..|  ||..|  . . .  .  . .  ..  .|   |  |    |  ..|| |.    
l....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei..tstl.gekkkthtvkhysykGWiekna

PSDVKQIWQVqsyLRKYTDGHPPVYMSMSGCGRAGTFALFETAHM----SLHN-EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
| . ..| ..   |.  .| .. | .  .| ||. .|.| | ..     ||.. |   |. .. ||..|. |  ....  |..    ..
Pelareilni...lkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv

0048076 (Phosphotyrosine protein) phosphatases II 359-466 7.4e-09 31.0 In-house 38-139 (145) alignment
Range on Protein: 359-466
Range on HMM: 38-139/145.0
SVSNGTYkTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVY-MSMSGCGRAGTFALFETAHMslhneqPSLNMVKCLENVRNGRLHSVQNLS
|  .. .  ..  ..| .||  ..|.. ......  ..... . . ||.   . |.||.||...    ..       .... ..|| ||. | ..|.| .
selelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpg

QFSVVYTLI
|.  .| ..
qlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 356-464 1.3e-08 30.2 In-house 48-139 (144) alignment
Range on Protein: 356-464
Range on HMM: 48-139/144.0
KvlsvsngtyktfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD-GHPPVYMSMSGCGRAGTFALFETAHmslhnEQPsLNMVKCLENVRNGRLHSVQ
             .. ... .||  ..|.. ... ..  ..... . |.| .   . |.||.||...    .     ..  |.. ..|. ||. | ..|.
e............giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavp

NLSQFSVVYT
| .|.  .. 
npgqlrfLle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 237-383 2.1e-08 28.1 In-house 89-237 (244) alignment
Range on Protein: 237-383
Range on HMM: 89-237/244.0
KNHFV-SNMDKNRFVDVICMDHSRVKLTDS----SYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFnkfggNSVFPQNQD
|. |  .|  |||    . .| .|| |. .    .|| | .|  |  . . |||| ||. |. |||.|....... .... .  |      .  .|. . 
kdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep

FLKFE-DRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFiHVHHYKNWPH-GSIP
.  .| |  . . .  .    |  ||.. |  | .....  .    |||  |. |
lewyeeditvtltdrdefknikasnleiesdmneshqal.tmfqisnwpsdgttp

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 256-313 1.1e-07 26.2 In-house 6-61 (130) alignment
Range on Protein: 256-313
Range on HMM: 6-61/130.0
DHSRVKltDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKcVLLIMTD
. ||..  .  ||.|..| |   ... .||| ||. |. |||.|.... .  ||...  
evsrlq..gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvn.vlvvlgs

subfamily_CG42327_pd Subfamily CG42327 240-389 2.1e-06 21.6 In-house 25-183 (319) alignment
Range on Protein: 240-389
Range on HMM: 25-183/319.0
FVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF
 |.  ||.|...|. . ..|| |        . |..|..|     .    | .| .|  ..||||... .|. . .. .    |         .| ..  
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYK-NWPHGSIPSDVKQI
   .        .|. | .. . .  | . .   .   .. ||  .|..  .|.. . .
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaal

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 266-315 3.1e-06 20.7 In-house 91-143 (349) alignment
Range on Protein: 266-315
Range on HMM: 91-143/349.0
SYIHANWVDL---NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
 || ||.. |   .  || | || ||  |  ||...|. ...| || .  | |
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke