Synonym: CELE_C46A5.1, C46A5.1
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 197-485 | 9.9e-187 | 613.7 | In-house | 1-294 (303) | alignment | ||
Range on Protein: 197-485
Range on HMM: 1-294/303.0
ISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSSYIHANWVDLNSSKKAILTQLPLSHTASDFW
||.||..||||.|..||..||||||||||||..||||..|||.||.||||||||||||.|||.|||.|||||||....|.||||||||||||||||.|||
iseekkqkwkllakrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfw
QMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSD-----VKQIWQ
||||.||.|||||..||.|..|.||.||||.||||||||.|.|||||||.||||.||.|||||||||.||.|.||||||.|||.||||| ||||||
qmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq
VQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEEQEN
.||.||||.|..|.||||.||||||||||||||||.|||.||.||..|||||||||||||.|||||||||||||.|||||.||| | . .. |
lqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpn
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 203-471 | 3.2e-61 | 202.7 | In-house | 3-277 (317) | alignment | ||
Range on Protein: 203-471
Range on HMM: 3-277/317.0
TKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNS-SKKAILTQLPLSHTASDF
....|. . || |... .|||.. . ....| ... |.||||..|... |||||||.. |.||.|..|| . ..| |.|| ||..| ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF
WQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQ
|.|. .|...... ... |... .|. ...|...| .... .... .|..| .| |. .. .. .....||..||....|.. .....
wrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl
SYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
...|.. .|.| . ... |.||.|||.. ..... |. |. ... .... .|. | ..||...|. .|....|...
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylk
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 196-471 | 6.2e-58 | 191.9 | In-house | 10-290 (297) | alignment | ||
Range on Protein: 196-471
Range on HMM: 10-290/297.0
KISDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPhISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLNS--SKKAILTQL
. ....|. . |. . . ... .. .|||.. . |. .| ... |.||||..|... ||||||| ||.||.|..|| . ..| |.||
esipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg
PLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQDflKFEDRFIRVGEFKQvelGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDV
||..| |||.|. .|...... ... | .. . .|.... ...| .... .... .|... .|.|.|. . ......| .||....|...
PlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppsl
KQIWQVQSYLRKYT----DGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
... .. ..|.. .|.| . ... |.||.|||.. ... |. | ... .... .|. | ..||..||. .| ...|...
ellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 229-474 | 1e-57 | 191.1 | In-house | 25-281 (297) | alignment | ||
Range on Protein: 229-474
Range on HMM: 25-281/297.0
GYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVF
.|....| ... |..|||. |... ||.||||.|.. ||.|..||. . ..| |.|| ||..| |||.|. .|...... . .. | .. . .
llllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqyw
PQN-QDFLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSN--GTYKTFIHVHHYKNWPHGSIPSDVKQ----IWQVQSYLRKYTDGHPPVYMSMSGCGRAGT
| . ...|...| .... ....| | ... | .| |.. . .. .....||..||. ..|..... |..|...|.....|.| . ... |.||.||
pleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgt
FALFETAHMSLHN--EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNG
|.. ..... |.. ... ....... .|. | ..||.|.|. .| ...|... .
fiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 205-469 | 2.5e-56 | 186.5 | In-house | 7-276 (278) | alignment | ||
Range on Protein: 205-469
Range on HMM: 7-276/278.0
WKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQ
. .| |... . .|||.. . ....| ... |.||||..|... |||||||.. |.||.|..||. . ..| |.|| ||..| |||.
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr
MIIDQKIKCVLLIMTDGEFNKFGGNSVFPqnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYkTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLR
|. ........ .... |... . .| ...|...| .... .... . . ..|.| .| . .....||..||....|........ ..|
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavr
KY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
.. ....| . ... |.||.|||.. ..... |..|. ... .... .|. | ..||..||. .| ...|.
ealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 243-468 | 7.6e-56 | 184.5 | Pfam-A | 1-235 (235) | alignment | ||
Range on Protein: 243-468
Range on HMM: 1-235/235.0
NMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
|..|||. |....|..|||| ..| ||.||.|.. ..|| |.|| ||..| .|||.|....|.|.. .. .. | .. . .| .....|...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd
RFIRVGeFKQVELGKGWNLKVLSVSNGTYKT---FIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAHMSLHN
.... |. | |...|..|.... . .. ....||.|||. ..|...|..... ..|.. . .| | ... |.||.|||.. ... ..|..
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea
EQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|. ..........|. | ..||.|.|. ..| .|.|
eee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 243-468 | 7.6e-56 | 184.5 | In-house | 1-235 (235) | alignment | ||
Range on Protein: 243-468
Range on HMM: 1-235/235.0
NMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
|..|||. |....|..|||| ..| ||.||.|.. ..|| |.|| ||..| .|||.|....|.|.. .. .. | .. . .| .....|...|
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd
RFIRVGeFKQVELGKGWNLKVLSVSNGTYKT---FIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAHMSLHN
.... |. | |...|..|.... . .. ....||.|||. ..|...|..... ..|.. . .| | ... |.||.|||.. ... ..|..
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea
EQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|. ..........|. | ..||.|.|. ..| .|.|
eee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 202-470 | 1.6e-55 | 184.0 | In-house | 9-299 (308) | alignment | ||
Range on Protein: 202-470
Range on HMM: 9-299/308.0
LTKWKLVAQETLKDDANIAVNEFEK------------------VSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT-DSSYIHANWVDL---NSSK
|... .. ...|. . .. | .. | | . .. .| .. |.||||..|... ||||||| .|.||.|..||. ....
lelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklpr
KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN--QDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN--GTYKTFIHVHHYK
| |.|| ||..| |||.|. .|..... ... | .. .| . ...|.... .... . .. ... . .| ..| . . .... ||.
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhyt
NWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|||....|........ ..||. .|.| | ... |.||.|||.. .... |. | ... ... .| | ..||...|. .| ...|..
nWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleyl
|
|||||||||
DSPc_SM00195 | 224-469 | 2.8e-55 | 182.9 | In-house | 6-261 (263) | alignment | |||
Range on Protein: 224-469
Range on HMM: 6-261/263.0
FEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||. . | ....... .|..|||. .....||.||||.. |.||.||..... ..|| |.|| ||..| .|||.|....|.|... .. . |
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeee
FNKFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVElgKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--GHPPVYMSM
.| .. .|.. .. .|.. . . | .... . ..|..|.... . ........|||||. ..|.. |.. .. ....| .. .| | ..
ngkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs
SGCGRAGTFALFETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
|.||.|||.. ... .|..|. ... ......|. | ..||.| |....|. |.|
aGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
|
|||||||||
PTPc_SM00194 | 224-469 | 2.8e-55 | 182.9 | In-house | 6-261 (263) | alignment | |||
Range on Protein: 224-469
Range on HMM: 6-261/263.0
FEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||. . | ....... .|..|||. .....||.||||.. |.||.||..... ..|| |.|| ||..| .|||.|....|.|... .. . |
fekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeee
FNKFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVElgKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--GHPPVYMSM
.| .. .|.. .. .|.. . . | .... . ..|..|.... . ........|||||. ..|.. |.. .. ....| .. .| | ..
ngkekcdrywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCs
SGCGRAGTFALFETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
|.||.|||.. ... .|..|. ... ......|. | ..||.| |....|. |.|
aGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 200-471 | 4.7e-55 | 182.8 | In-house | 9-305 (307) | alignment | ||
Range on Protein: 200-471
Range on HMM: 9-305/307.0
EKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPP---HISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLN---------SSKK
....|. | ...|.|. .. ||||. . .. ..| ... |.||||..|... ||.|||| ||.||.|..|... ...|
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk
AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS---NGTYKTFIHVHHYKNW
|.|| ||..| |||.|. .|...... .... |... .|.....| ... .... .... .|. . .| |. . .....||..|
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgw
PHGSIPSDVKQIWQ----VQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPS--LNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
|....|...... . |...|.....|.| . ... |.||.|||.. .. |..|. ... .... .|. | ..|||..|. .| ...|..|
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 223-470 | 1.6e-54 | 180.6 | In-house | 5-274 (284) | alignment | ||
Range on Protein: 223-470
Range on HMM: 5-274/284.0
EFEKVSGYLPP---HISKNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDL------NSSKKAILTQLPLSHTASDFWQMIIDQKIKC
|||.. . .. ..| ... |..|||..|... ||||||| ||.||.|..|| ...|| |.|| ||..| |||.|. .|....
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv
VLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN---GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD--
. ... |... .|.....|...| .... . .. ... . .|...| . . .....||..||. ..|........ ..|.. .
IVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenl
--GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|.| | ... |.||.|||.. .... |..|.. ... ... .|. | ..||.|.|. || ...|..
pgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 205-470 | 1.7e-54 | 180.6 | In-house | 10-286 (288) | alignment | ||
Range on Protein: 205-470
Range on HMM: 10-286/288.0
WKLVAQETLKDDANIAVNEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFW
. . ...|... .. .|||.. .| ....| ... |..|||..|... |||||||. .|.||.|...|. |...| |.|| ||..| .|||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW
QMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS------NGTYKTFIHVHHYKNWPHGSIPSDVKQIW
.|. .|..... ... |... .|. ...|...| ... . .. ... . .| |. . .. .....||.|||. ..|.......
rmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll
QVQSYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
. ..||. .|.| | ... |.||.|||.. ..... |..| ... . .. .|. | ..||...|. || ...|..
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 220-470 | 1.9e-51 | 170.5 | In-house | 14-272 (273) | alignment | ||
Range on Protein: 220-470
Range on HMM: 14-272/273.0
AVNEFEKVSGYLPPHI-SKNHFVSNMDKNRFVDVICMDHSRVKL--TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|||.. . |.. | .. |.||||. |... ||||||| .|.||.|..||. |...| |.|| ||..| |||.|. .|..... .... |
lleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve
FNKFGGNSVFPQNQD--FLKFEDRFIRVGEFKQvelGKGWNLKVLSVSN--GTYKTFIHVHHYKNWPHGSIPSDVKQ----IWQVQSYLRKYTDGHPPVY
.. .|.... .|.... .... . .. ... . .| ..| .. .....||..|| ..|..... |..|...|... ...| |
lgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvV
MSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
... |.||.|||.. .... |. | ... ... .|. | ..||...|. .| ...|..
HCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 222-471 | 7.9e-51 | 168.4 | In-house | 12-273 (278) | alignment | ||
Range on Protein: 222-471
Range on HMM: 12-273/278.0
NEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKltdsSYIHANWVDLNsSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGG
..... . | |. . ...|.||||..|... |||||| ||.|...| .|| |.|| || .|..|||.|. ...|.... ... | ..
efefllllgipseitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc
NSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSV---SNGTYKTFIHVHHYKNWPHGSIPSDV--KQIWQVQSYLRKYT---------------D
.| ...| ..| .... ...... . |.| . .. .. .....||..|| ...||. |..... ..|.. .
aqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds
GHPPVYMSMSGCGRAGTFALFETAHMSLhneQPSLNMVKCLENVRNGRLH-SVQNLSQFSVVYTLIAEHVL
|.| . . |.||.||... . | .. ... .... .|. | . .||||.|. .| ...|..|
ggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 236-471 | 9.5e-49 | 161.6 | In-house | 4-247 (249) | alignment | ||
Range on Protein: 236-471
Range on HMM: 4-247/249.0
SKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQn
| ... |.||||..|... |||||||.. |.||.|...|. .... |.|| ||..| .|||.|. ...|.... .... |... . .|.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.
QDFLKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT----DGHPPVYMSMSGCGRAGTFALF
...|...| .... .... ... . .| .. . ... .| .||. ..|...... . ..||. .|.| . ... |.||.|||..
ggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa
ETAHMSLHNEQPsLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
.... |. |. ... ... .|. | ..|||..|. .| ...|..|
ylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallelll
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 239-468 | 1.5e-48 | 160.9 | In-house | 6-240 (243) | alignment | ||
Range on Protein: 239-468
Range on HMM: 6-240/243.0
HFVSNMDKNRFVDVICMDHSRVKLTDSSYIHANWVDLNssKKAILTQLPLSHTASD----FWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPqnQDFlKF
... |..|||. |....||||||| .|.||.||... .. |.||.||..| | ||.|. ...|.... .... | .... .| ... .
llpenlsknrysdilpydhsrvklegsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.ty
EDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK----------YTDGHPPVYMSMSGCGRAGTFALFET
.| .... .... . . ..|.. .. . .. ... .|| .||....|........ ...|. . .|.| . . . |.||.||... .
gdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaayl
AHMSLhneqpSLNMVKCLENVRNGRLH-SVQNLSQFSVVYTLIAE
.. | .... .... .|. | . .||..||. .| ...|
mllll.....gvdleeavkllreqRpgkavqtpsqyrflyealle
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 239-468 | 1.7e-48 | 160.5 | In-house | 5-241 (245) | alignment | ||
Range on Protein: 239-468
Range on HMM: 5-241/245.0
HFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDF
.. |.||||..|... ||.||||. ||.||.|..||. ..| |.|| ||..| |||.|. ...|.... .... |... . .|. ...
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ges
LKFEDRFIRVGEFKQvelGKGWNLKVLSVS--NGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK---YTDGHPPVYMSMSGCGRAGTFALFETAH
|...| .... .... ... . .|.|. .. .....|| .||....|......... ...|| ....| . ... |.||.|||.. ...
ltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml
MSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
. |. |. ... .... .|. | ..||..||. .| ...|
eqlekel.gvsleeavkelrsqRpgavqtpsqyrflyealle
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 242-470 | 1.5e-36 | 120.8 | In-house | 39-277 (290) | alignment | ||
Range on Protein: 242-470
Range on HMM: 39-277/290.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF-LK
.|. |||. |.. |.|||.|. .|.|| ||.. ..|.. | .| ||..| .|||.||...... |... | .|. . .|.... |.
envkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele
FEDrfIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD-GHPPVYMSM-SGCGRAGTFALFETAHMSLHN
|.. ..| .. . ... .. | | . . .. ||..|| .|| .|.. .. . .|.. . . |. . .|.||.|| . ... |..
fge..fevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka
EQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|. .|.. . . ..|. | || |...|| .|| |
ekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 236-468 | 1.3e-32 | 107.7 | In-house | 25-269 (290) | alignment | ||
Range on Protein: 236-468
Range on HMM: 25-269/290.0
SKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD--
.. .. .| ..||. || ||||.|| | || |. |.|. .. |||| ||..|.. ||||. .|| |.|... | .. . .||...
reaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek
FLKFEDRFIRVgEFKQVELGKGWNLKVLSVSNG-TYK-TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRK----YTDGHPPVYMSMSGCGRAGTFALFET
|..|| ..| .. . | . . ...| . | | . | .|| || ..|. . . .|. .| |.| .| ||.|||.| .|
ellledtklkv.kliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdt
AHMSLHNEQP--SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
. ..... |... | | ..|. || .| |. |. | |
clvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 240-467 | 1.7e-32 | 107.8 | In-house | 34-266 (273) | alignment | ||
Range on Protein: 240-467
Range on HMM: 34-266/273.0
FVSNMDKNRFVDVICMDHSRVKLTDSS-YIHANWVDLNSSK---KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKF
.|.||||. .|. .|..|||| |.. || |... .. | ..|..| || .|..|||||. .|| . . .. .. | .| . .|.... ||
kkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv
EDRfIRVGEFKQVELgKGWNLKVLSVSNGTYKTFIHVHH--YKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMS-MSGCGRAGTFALFETAhMSLHN
..| ..| |...| .|.... | |.. . ..| | . .|| ..|| ... |. ...|. . . |. . .| ||.||. ... . | .
snr.levellkvqkl.dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv.lglie
EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
. .... . ....|. | || |. || |
rdkefdvkeivrklreqrqgvvqtkdqyifvykail
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 221-471 | 2.9e-32 | 107.1 | In-house | 26-282 (564) | alignment | ||
Range on Protein: 221-471
Range on HMM: 26-282/564.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
.|..|.. .... . | |||. ... |||||.| .| || |...| ..| | || ||..| .|||.|. .|..... ..
eeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkl
GEFNKFGGNSVFPQNQdFLKFEDRFIRVGEFKQVELGKGWNLKVlSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMS
| .| .. .|... .... . . | .... ..|. . .. . .. |. .||. .| ... .. . |... | .| | .
eEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa
GCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
| || ||| . ...|. ... ......|. | . ||. .|.. ... |.| .
GVGRTGtfividamlerikeek.tvDiyqyvkalrkqRnamVqteeQYiFiheaileala
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 235-466 | 3.2e-32 | 106.6 | In-house | 33-271 (280) | alignment | ||
Range on Protein: 235-466
Range on HMM: 33-271/280.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNSSK-----KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
||. . |..|||. |.. |. ||||..|. || ||.|.... . | || ||..||.|||||. .||.. .... | | . .|.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe
NQDFLKFEDRFIRVGEFkqvELGKGWNLKVLSVSNGTY--KTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSMSGCGRAGTFALFE
..| |.. . ... . . | . |. | ... . . |. | .|| ..|.| ... .. . .||. | .| | .| ||.| . |.|
tedeleygefsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille
TAHMsLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
|| . | ... ...... . ..|. | ||. ||. | |
tala.lieaaepvypldivrtmrdqramlvqtasqykfvCeai
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 241-468 | 1e-31 | 105.1 | In-house | 39-274 (281) | alignment | ||
Range on Protein: 241-468
Range on HMM: 39-274/281.0
VSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLK
|. |||..... |..|||. ... || ||.|. ... |. | || |. .. .||||...||.. . .. . | .| .|... ||
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselk
FEDRFIRVGEFKQVELGKGWNLKVlSVSNGTYKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG---HPPVYMSMSGCGRAGTFALFETAHMSLH
. | .. . .. . ..|. . ..| .. .. .|..|| .|.. |.. . .. ..|.|. .| | .| ||.||. .... ...
ygdvtvkstaeeekatyierkfkl.eresgetre.veqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave
NEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
.|...|.. ....|. | || . |.. || . .
aeleeldvkavvaelrkernlmvqtvvqyefvykavld
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 222-478 | 1.3e-31 | 104.6 | In-house | 14-278 (285) | alignment | ||
Range on Protein: 222-478
Range on HMM: 14-278/285.0
NEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL--TDSSYIHANWVDLNSSKK--AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFN
.|. ||.|| . . .| | ||. || |.. .|| | | ||||.|. . . | || || | ||||.|| ..|| ||.. | |
lhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfegg
KFGGNSVFPQN-QDFLKFEDRFIRVGEFKQVEL-GKGWN-LKVLSVSNGTYKTFIHVH-HYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVYMSM-SG
.|.. . .|| | . | |. . | .| | |. . . . . | . || | | . . .. ...| |. . .|
vekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsag
CGRAGTFALFETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKK
||. || . | . . |.| ..|. . ..| |...||. || ..| .. |...|.|. ..
vgrtatfvgidyatirim.enpniemldivremramrfqavqshmqflflyvvlmeyfigegvver
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 217-470 | 1.7e-31 | 103.8 | In-house | 25-285 (302) | alignment | ||
Range on Protein: 217-470
Range on HMM: 25-285/302.0
ANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLN-SSKKAILTQLPLSHTA---SDFWQMIIDQKIKCVLLI
. .||.|.. . . . | .|..||. || ..|. .|||. ||..| |.. ... ||.||| . .. .||.|. ..||. | ..
taevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil
MTDGEFNKfGGNSVFP-QNQDFLKFEDRFIRVGEFKQVELGK-GWNLKVLSvsNGT-YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSY--LRKYTDGHPP
. . | .| . .|| . .|...... |. . ...| | . . || .| .. | . .||.. ..| . .. . .| ..
vgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlP..egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadent
VYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| .|. |.||||.| .| .|... |. ....|. | ..|..|.|. .| .. ..
vivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyi
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 241-469 | 1e-30 | 102.1 | In-house | 54-289 (298) | alignment | ||
Range on Protein: 241-469
Range on HMM: 54-289/298.0
VSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDfLK
.| .|||. |.| .|.||| |.. | || | ... . ..| |.|| || .| .|||.|.....|... .. . | .| . .|... .
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.et
FEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSM-SGCGRAGTFALFETAHMSLH
... ... . .. .||| . .. . .. .. |. .|| ..|. . . .. . |... . || . .| ||.||| .. ..
ygeitvsllskeefadlivrklkvskkkeekere.vrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervk
NEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
.|| .. . . .. .|. | ..|| .|.. .|... |
keq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 221-467 | 3.8e-30 | 99.9 | In-house | 28-282 (293) | alignment | ||
Range on Protein: 221-467
Range on HMM: 28-282/293.0
VNEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWV-DLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMT
..|.|... ..... | .|||. ... ||||||| ..| || ||.. ..|| .. | || || .| |||.|. ..| . ....
seeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltq
DGEFNKFGGNSVFPQNQDFLKFEDRFIRVGEFKQVelgKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT----DGHPPVYM
| | . .|.... . | . . . ... . | .. |...... .. .. .|.. || .|.. |.. . .|... . .| |
lvekgkvkCeeYWPadeepvlyGdikvtlvaeeel...edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh
SMSGCGRAGTFALFETAHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
.| ||.||| .. .... . .... . ..|. | . ||. .|. .... .
CsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvl
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 221-470 | 1.1e-29 | 98.5 | In-house | 26-283 (319) | alignment | ||
Range on Protein: 221-470
Range on HMM: 26-283/319.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
.||..... . .... . | .|||. ... .|..||.|. .| || |...| . .| | || ||..| .|||.|. .... .|... .
ekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl
GEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYM-SM
| | . ..|. ..| .. . . | .. | .||. |. . ..|..|| .| . ... .. .|| ... . |. .
veklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCs
SGCGRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| || ||| . | . .|. |.. . ..| | ||. .|....| . | |
aGvGRtGtfivld.amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 243-469 | 1.1e-29 | 98.1 | In-house | 43-279 (288) | alignment | ||
Range on Protein: 243-469
Range on HMM: 43-279/288.0
NMDKNRFVDVICMDHSRVKLTDS--SYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKFEDR
. .|||. |.. ||.|||| .| || | .| . . | || || |..|||.|. .|| . . .... | .| .. .|.... ||.|
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdl
FIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPS----DVKQIWQVQS-YLRKYTDGHPPVYM-SMSGCGRAGTFALFETAHMSLHN
. . . .. | .||. .. . |. |. ....||. .|. .. . .|.| | . . |. . .| ||.|.||| .| |..
svtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelek
EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
.. |.... .. .|. | ..||. .|. .| . |.
gnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 234-468 | 1.2e-29 | 99.4 | In-house | 37-278 (314) | alignment | ||
Range on Protein: 234-468
Range on HMM: 37-278/314.0
HISKNHFVSNMDKNRFVDVICMDhSRVKL-----TDSSYIHANWVDLNssKKAILTQLPLSHTASDF----------WQMIIDQKIKCVLLIM-------
.| . .. |.||||. |....| .||.| .|.||.|..|| .| | || ||..| || |.|........ . |
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla
--------------TDGEFNKFggNSVFPQNQDFLKfedrfirvgefkqvelgkgwnlkvlSVS---NGTYKTFIHVHHYkNWPHGSIPsDVKQIWQVQS
. .. | ......|| .. . .. |..... ..| || | . ......
delsrLdaAlgKtpllildgng..neptaadlellk.........................eelydpelferlgikylri.pvpDgsap.lledfdefle
YLRKYTDGHPPVYMSMSGCGRAGTFALfeTAHMSLHNeqpSLNMVKCLENVRNGRL-----HSVQNLSQFSVVYTLIAE
..... .|.| . ..|.||.|||.. .| . ... ... ..|| ||. | .....| |. .. . |
fieeadkggpvlvHCkaGkgRtgtfvv..aaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealle
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 241-469 | 2.2e-29 | 97.4 | In-house | 7-241 (250) | alignment | ||
Range on Protein: 241-469
Range on HMM: 7-241/250.0
VSNMDKNRFVDVICMDHSRVKLTDSS------YIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFgGNSVFPQNQDfLK
.| .|||. |.| .|.||| | .. || | ... . .| | || ||..| |||.|....|.. .... . | .| . .| .. |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka.ek
FEDrfIRVGEFKQVELGkGWNLKVLSVSNGTYKTF--IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKY---TDGHPPVYMSMSGCGRAGTFALFETAHMS
. | ..| ... | . . ..| .|. . . . |. .|| ..| . . .... ... .. | . .| ||.|.| ..
yGd..vtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler
LHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
|..|. ... | .. .|. | |.|. |.|.. ||..| .
lkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilka
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 239-470 | 2.6e-29 | 97.2 | In-house | 38-290 (297) | alignment | ||
Range on Protein: 239-470
Range on HMM: 38-290/297.0
HFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQD
. .|. |||. ||.|.|..||.|. | ||.||.|| ||| | || || .| ||||.|. .|.. .... | . . .| ....
klranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees
FLKFEDrfIRVGEFKqVELGKGWNLKVLSVSNGTYKTFIHVHHY--KNWPHGSIPSDVKQIWQVQSYLRKY--------------TDGHPPVYMSM-SGC
.| | ..| . . || . .. .|| ..| . . .| |. || .||. ... .| . |.. ||. . .|
saefgd..lsvsnve.veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi
GRAGTFALFETAHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
||.|||. .. . |.. . ...|.... .|. | .|.| |. | . |.
GrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 206-466 | 3e-29 | 96.6 | In-house | 16-279 (290) | alignment | ||
Range on Protein: 206-466
Range on HMM: 16-279/290.0
KLVAQETLKDDANIAVNEFEKVSGYLPPH-ISKNHFVSNM--DKNRFVDVICMDHSRVKLTDS---SYIHANWVDLNsSKKAILTQLPLSHTASDFWQMI
|. .. . |. ..|.. .||. ||| . . .. | | |||. ||.| | .|| | | |.|||.|. |||| .| |. |.|.|.
kfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGl.kamfiltqGalkdtvidiwrmv
IDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ-DFLKFEDRFIRVGEFKQVELG-KGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPSDVKQIWQVQSYLR
...|. . .. | | . .|... . | | . . | .. . . | | . .| . . |. . | || |.. . .. ||
lqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhl.kikswpdksvalstlallrtlrilr
KYTdGhPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
| . | | | .| ||.|||. |.. | . . .|.... .|| || ||| |. .. ..
kas.G.pvvvhcsaGiGrtGtfvaievglqilldGk.eldlldlvralrnsrlnsvqvdiqylalveil
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 209-470 | 4.4e-27 | 89.9 | In-house | 7-277 (307) | alignment | ||
Range on Protein: 209-470
Range on HMM: 7-277/307.0
AQETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT----DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQK
|.||. . |.||.... . | .. . | .| ||||. || |.|..|. .. | |||||.. . || | .| || | .|| |.|..|
vqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek
IKCVLLIMTDGEFNKFGGNSVFPQNQDF-LKF--EDRFIRVGEFKQVELG---KGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPS-DVKQIWQVQSyL
...|... | | . .| .. | | . . | | .. .| . |. | | . |. ..||| .| .. | ...
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainllea.v
RkyTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| | | | .| ||.|| . . . .| | .|..|. | ...|. |. .. .. |.
r..ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 213-487 | 5.1e-27 | 89.6 | In-house | 27-311 (330) | alignment | ||
Range on Protein: 213-487
Range on HMM: 27-311/330.0
LKDDANIAVNEFEKVSG-YLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKI
||.. .||. . . . |..|||.|... |.||| |. .| || | ..| | | | .| |...| |||.|| .||
saddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqks
KCVLLIMTDGEFNKFGGNSVFPQnQDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGT---YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT-
.... | .. . .|. . . . . . | . . .. .. | ....| . .. |.. ||. .|.. . . .. ..|
ativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq
-DGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLgNGIGKKDVEEQENSI
. | | .| ||.||| ... .. |. ... . ....|. | . || . |. .| . |. | | . || |. .
qsagpivvhcsaGvGrtGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl.ygdteldvsslekhl
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 243-473 | 7.6e-27 | 89.5 | In-house | 1-174 (182) | alignment | ||
Range on Protein: 243-473
Range on HMM: 1-174/182.0
NMDKNRFVDVICMDHSRvkltDSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMtdgefnkfgG----Nsvfpqnqdflkfedr
|.||||..|....|||| |..||.||... . . |.|| || .| ||..|. ...|.... . .
nldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...............
firvgefkqvelgkgwnlkvlsvsnGTYKTFIHVHHYKNWPHGSIPSdVKQIWQVQSYLRKytDGHPPVYMSMSGCGRAGTFALFEtahM---Slhneqp
.. .. ..| .|| ...|. . .. . .. .|.| . . |.||.||... .
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaay...lmkkl......
SLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
.... .... ||. | ..|....|. ... .. |..|..
gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 222-472 | 8.2e-27 | 89.1 | In-house | 24-282 (318) | alignment | ||
Range on Protein: 222-472
Range on HMM: 24-282/318.0
NEFEKVSGYL-PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
.|.|..| . | | |||..... ||.||||.. | || ||..| . .||| | .| ||..| .|||.|. .|. . ....
eeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe
GEFNKFGGNSVFPQNQDfLKFEDrfIRVGEFKQVELGKgWNLKVLSVSNGTYKTF--IHVHHYKNWPHGSIPSDVKQIWQVQSYL---RKYTDGHPPVYM
| | . .|... .... ..| ..|||.. . |. ..|.. . .. .|| .|| ..|... .. .. . .. .| |
eergkakvhryWPskgs.rsygk..lvvelkeevelsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh
SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
.| ||.|.| .. ...|. ... . ...|. | || .|. ..|. . | .
CsaGvGrtGvfiavdillerikaea.lvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 223-469 | 1.3e-26 | 88.4 | In-house | 28-295 (300) | alignment | ||
Range on Protein: 223-469
Range on HMM: 28-295/300.0
EFEKVSGY-LPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----SSYIHANWVDLNSS---KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
|.|... . ..| . | .|||| ||. ...||.|. . || | . . .. | .| || .| |||||. .|... .... .
eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmltee
GEFNKFGGNSVFPQN---QDFLKFEdRFIRVGEFKQ-VELGKGWNLKVLSVSNGTYKTFIHVhHYKNWPHGSIPSDVKQI----WQVQSYLRKYTDGH--
| | . ||.. .. ..|. .| . .|.. . ||. . . ..| .|. |..|| .|.|||. .||| || ..
eedgkeksfkyfPkleskkktvefg.kfkvttkfsedsdsvittglklkhlpskeertvwhl.qytDWpdhgvPeDvkgflsyLeevqsvrrktnseves
----PPVYM-SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
||| . | ||.| | . .|.... .... | |. .|. | . ||.|.|. ||... ..
keskPPvlvhCsaGvGrtGvlilsdlliatlehne.eidikkvlarLreqrmllvqtlaqYkfvYkvliky
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 240-467 | 3.8e-26 | 86.8 | In-house | 44-276 (288) | alignment | ||
Range on Protein: 240-467
Range on HMM: 44-276/288.0
FVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFL
| .|||. ... .|. ||||.. . || |...| . . || | || || .| |||... ..|.. .. . | .| . .|....
lavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk
KFEDRFIRVGEFKQVElgkGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG--HPPVYMSMSGCGRAGTFALFETAHMSLH
.. . . . | |..| . |. | . . . |. ..|. || ..| . ... .. . . . | . . | ||.||| ... ..
nyGsvtvtlveskele...dfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidave
NeQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
. . .... ....|. | ||.|.|. .| ..
e.edyiDvagtvaklRkqRallvqtlkqYefiyevll
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 238-473 | 7.2e-26 | 85.5 | In-house | 37-293 (296) | alignment | ||
Range on Protein: 238-473
Range on HMM: 37-293/296.0
NHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQd
.. |..||| |.|. |. || |. .| || | .|| || | |. | .| .||... |..|..| . ..|.| .| .|...
glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks.
FLKFEDRFIRVGEFKQVELGKGWNLKVLSV---------SNGTYKTFIHVHHYKNWPH-GSIPSD----VKQIWQVQSYLRKY---TDGHPPVYMSMSGC
.. . |. . | || | ...|. . . ... ... |. ..|. .. . .|... .| . | | .| |
keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa
GRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
.|.| . . | . | ... ... . . .|. | . |.| .. .| .. |.|| |
sRsGvylaid.anlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 232-470 | 8.2e-26 | 85.7 | In-house | 32-271 (288) | alignment | ||
Range on Protein: 232-470
Range on HMM: 32-271/288.0
PPHISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS--YIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN
. . . |..| ..|. .. . | .||||.| . ||.|| | . .. | .| || | .|.|.... .. .... | | . || .
asidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk
QDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSN-GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAHM
. |. | |.... | .. .| .|. | | .. . |...|.. ..| . . .. |.... .| | .| | ||.||..| |
lGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq..kPivvhssaGvGrtgtlililiale
SLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
|| . | . . |.. |. | ...| |. |. .. |..
slrldd.flgirsllaklreerfkaiqtemqylyvhrcvleel
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 214-487 | 8.3e-26 | 85.8 | In-house | 17-302 (307) | alignment | ||
Range on Protein: 214-487
Range on HMM: 17-302/307.0
KDDA-NIAVNEFEKVSGY-LPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKI
| |. ..|.||. . . . | |||. |.. |. ||||. ||.|| |... .|| | | |. |. |||.|| .|..
krdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqev
KCVLLIMTDGEFNKFGGNSVFPQNqDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGT----YKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYL-RKY
. . .. .| |. . .|.. | ...| ... .... . .|.| . . . . . .||..|. .| . . .. . . |
tlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrely
TDGHPPVYM-SMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLgNGIGKKDVEEQENSI
. |. . | ||.|.| .. |..|. ...... ..|. | ||.| |.. .| .... | .||.. |..|
klnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldyss.ygdtdedvddledai
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 198-473 | 1.8e-25 | 84.9 | In-house | 14-295 (319) | alignment | ||
Range on Protein: 198-473
Range on HMM: 14-295/319.0
SDEKLTKWKLVAQETLKDDANIAVNEFEKVSGYLPPHISKNH--FVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPL
| .. . .| .. ..|| .. || ... .. ... | ||||..... |...||| | || | .|. . .| | .| ||
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl
SHTASDFWQMIIDQKIKCVLLIMtdgefnKFGGNSVFPQNQDfLKFEDRFIRVgefKQVELGKGWNLKVLSVSN-G--TYKTFIHVHHYKNWPHGSIPS-
| |||.|| .... ..|. | .|.. . | | ..| . || . . .. . .|. | . . |. .|.. ||. |
dntladfWrmiweyncstivllt......kdkcsqywplkiv.ikeerfkvkv...dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdy
--DVKQIWQVQSYLRKYTDGHPP-VYMSMSGCGRAGTFALFEtAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE-HVLGN
|. .. . ..|.. ... . | .|.||.|.. .. . .. .|. ... . ....|. | . ||.| |. .|. . | |..|.
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld.vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 239-470 | 4e-25 | 83.3 | In-house | 16-264 (270) | alignment | ||
Range on Protein: 239-470
Range on HMM: 16-264/270.0
HFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVD--LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD
... . ||. |.. ..||.| . . || ||.| ...|| | .. || | ..||.||...| ...... | .. . .|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk
F-LKFEDRFIRVGEFKQVElGKGWNLKVLSVS-NGTYKTFIHvHHYKNWPHGSIPSDVK----------QIWQVQSYLRKYTDGHPPVYMSMSGCGRAGT
.|.|| .|.| ... .|. |. | . .|. . .| ..|..|| ..|.. . .|. . .. ...| . | ||.||
ekvkledgkikvlalseek.eegyiltrlrleekgeerrlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt
FALFETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
. . ..| |. |. ...... .|..|. | || |. .| ..|..
lialDiavrlLe.etkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 240-470 | 8.7e-25 | 82.3 | In-house | 51-297 (306) | alignment | ||
Range on Protein: 240-470
Range on HMM: 51-297/306.0
FVSNMDKNRFVDVICMDHSRVKL-----TDSSYIHANWVD---LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF
..|. |||. .. .||.||.| ..| || || .. .|.|. | || |..| ||||.|. ... . .... .. | .| .|....
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek
LKFEDrfIRVGEFKQvELGKGWNLKVLSVS---NGTYKTFIHVHHYKNWPHGSIPSDVKQI----WQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALF
.. . |.| . .. . . ..|. |||| ... . .. .|.|.|| ..|.| ... .|.. .. . . | | .| || ||| .
eeyGk..isvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi
ETA--HMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
.. .. . . ... |. . ||. | || .|. ||. |....
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 240-482 | 1.3e-24 | 81.3 | In-house | 44-301 (563) | alignment | ||
Range on Protein: 240-482
Range on HMM: 44-301/563.0
FVSNMDKNRFVDVICMDHSRVKLT-----DSS--YIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnQDF
.| ||| .... .|.|||||. ... || ||..| . ||. | || || .|. |||.|| .|. . . .| | .. . .|. ..
kpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.des
LKFEDRFIRVGEFKQVELGKGWNLKVLS--VSNG---TYKTFIHVHHYKNWPHGSIPSD-VKQIWQV-QSYLRKYTDGHPPVYMSMSGCGRAGTFALFET
.... .. | ... | .|.. . .. .. . .|| .|| . |. . .. | .| . .. | | .| ||.||. ..|
etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldt
AHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNG--IGKKDVEE
. ...|. . |. . | .| | . ||. |. .. . | .... . ...|||
llkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 237-469 | 2.3e-24 | 80.9 | In-house | 22-267 (274) | alignment | ||
Range on Protein: 237-469
Range on HMM: 22-267/274.0
KNHFVSNMDKNRFVDVICMDHSRVKL-------TDSSYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
. . . |||. ... ..||| | ||||| ||.. || . || ||..| .|||.|| .... .... | |. . ||.
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd
NQDFlKFEDRFIRVG-EFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYL---RKYTDGH--PPVYMSMSGCGRAGTFAL
..|. . ..|.. | ..... ...... |.... . . .. . | .|| | |.... .. |. .. . | | .| ||.| |
aedy.eiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia
FETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH
. | |..|. ....| |.| | ||. .|. ... ....
isiavrqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralcly
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 241-473 | 4.6e-24 | 80.4 | In-house | 23-259 (284) | alignment | ||
Range on Protein: 241-473
Range on HMM: 23-259/284.0
VSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMtdgefnKFGGNSVFPQNQDfLK
| ||||..... |...||| | || | .. . .| | || || | |||.|| .... ..|. | .|.. . |
dqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkiv.ik
FEDRFIRVgefKQVELGKGWNLKVLSVSN-G--TYKTFIHVHHYKNWPHGSIPS---DVKQIWQVQSYLRKYTDGHPP-VYMSMSGCGRAGTFALFEtAH
| ..| . || . . .. . .|. | . . |. .|.. ||. | |. .. . ..|.. ... . | .|.||.|.. .. .
eerfkvkv...dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld.vl
MSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE-HVLGN
.. .|. ... . ....|. | . ||.| |. .|. . | |..|.
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 243-473 | 9e-24 | 79.1 | In-house | 51-287 (297) | alignment | ||
Range on Protein: 243-473
Range on HMM: 51-287/297.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSkKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPqNQDFLKFED
|..|.|. ... .| ||||| || |. | .| | . | || | | |||.|..|.... .... | | .| .. .. .| |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvttfGd
RFIrvgEFKQVELGKGWNLKVLSVSNGT--YKTFIHVHHYKNWPHGSIPS--DVKQIWQVQSYLRKYTDG--HPPVYMSMS-GCGRAGTFALFETAhMSL
. . . |. .| . |.|..| . ... ... .||. ... ..... .. | .|| .. . |. . . | ||.| . . ..
vsv...vllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv.vae
HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGN
... .... . .. .|. | . || |.. || .. | .| .
akrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 222-480 | 1.6e-23 | 77.8 | In-house | 15-275 (281) | alignment | ||
Range on Protein: 222-480
Range on HMM: 15-275/281.0
NEFEKVSGYLPPHIS--KNHFVSNmDKNRFVDVICMDHSRVKLTD-------SSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIM
.|| .. | | . |. | | |||.... |.| |||.| . |||||.. |. |||| | | .|||.|| ... .....
qefsnlpgdppsdlctvfnqpvnn.kknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc
TDGEFNKFGGNSVFPQNQDFLKFEDRFIRvgEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKytDGHPPVYMSMS
| |. ||.| |.. .... . | | .| .| .|.|| .| . . .. .| ||| .
qfletnrekcaeyfprnahcclqfdklsv..syedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira..rstppvihcsa
GCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVR-NGRLHSVQNLSQFSVVYTLIaehvLGNGIGKKDV
| ||.||. | | |.|. .. . . .| || ||| | |. ... .. | |. |..
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvl....ldfgvaykqi
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 241-472 | 3.2e-23 | 77.3 | In-house | 46-290 (325) | alignment | ||
Range on Protein: 241-472
Range on HMM: 46-290/325.0
VSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKAIL-TQLPLSHTASDFWQMIIDQKiKCVLLIMTDGEFNKFGGNSVFPQN----Q
|..|||| .|. .|.||| | .| || |... . |. | .| ||..| |.|....| . |.... . .| .|.. .
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgksk
DFLKFEDRFIRVGEFkqvELGKGWNLKVLSVSNGTYKTfIHVHHYKNWP-------HGSIPSDVKQIWQVQSYLRKYTDGHPPVYM-SMSGCGRAGTFAL
| .| ... . |. |.| |..| .. .. ... |. .. | .. . .|. .. | . |. . ..| ||.|.|.
tfGglevklrtieei...sdyvhrvldvkqvkkGetrs.vkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis
FETAHMSLHnEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
. .| . |. .... . ....|. | |. |....|. ..| ..
lysalakvi.eesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 221-470 | 1.1e-22 | 75.6 | In-house | 25-283 (305) | alignment | ||
Range on Protein: 221-470
Range on HMM: 25-283/305.0
VNEFEKVSGYlPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTD
...... . | .. | |||..... .|..|..|| || || |..|| ..|| |..| || .| .|||..|.. |.. ....
eaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltkl
GEFNKFGGNSVFPQNQDF-LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDG---HPPVYMS
| .| . .|... .|.. . . ..|... .||. .. . . .. .|| .| . .. ..| | .
veggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhC
MSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| ||.|.| . | |..|. .... . | ..|. |. ||.| |. .. ..| .
sagvgRtGvfiavdialerlkkEe.vvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 235-468 | 3.1e-22 | 73.8 | In-house | 38-281 (290) | alignment | ||
Range on Protein: 235-468
Range on HMM: 38-281/290.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLT------D--SSYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVF
. . || .||| ... | |. | | .||.| ... . .|. |.|| |.|.|. |||..| ..|. ....... | .| . .
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYW
PQNqDFLKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWP-HGSIPSDVKQIWQVQSYLR-KYTDGHPPVYMSMSG-CGRAGTFALF
|.. | ... |.. . .... .|.| . ... .|. .. .. .||. .|... . ... . .. .| .. . |. ||...|
pds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaa
ETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
.|. . |. .... |.. | . ||| |. ...... .
attinkckteg.vidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 242-471 | 3.4e-22 | 73.7 | In-house | 42-278 (314) | alignment | ||
Range on Protein: 242-471
Range on HMM: 42-278/314.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFlkF
| .|||. |.. .|.|||.|. .| || |...| . ... | || || .| |||... |.. ..... | .. .|.. . .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..y
EDrfIRVgEFKQVELGKGWNLKVLSVSN--GTYK--TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFETAhMS
.| |.| |. ..|| . ....|.. ... .. .. .||. .| . . .. . | . . . | ..|.||.||| .. .
gd..ikv.elvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidiv.ld
LHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
. ... ... .. ..|. . |. |. .| | | .|
mieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 223-470 | 4.7e-22 | 73.3 | In-house | 29-280 (315) | alignment | ||
Range on Protein: 223-470
Range on HMM: 29-280/315.0
EFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
..| . | . . . | .|||....| .|.|||.| .| |. ||..| | .. | .| |. . |||... ...| .... |
dyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlve
FNKFGGNSVFPQNqdFLKFEDrfIRVGeFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGH--PPVYMSMSGC
.| . .| . . . | | |. | . . . ||| | . || || .| . .. ... . . | .|
gekrkaekywpdk..kviyGk..itvt.rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGv
GRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEH-V
||.||| ... .. |. ... . ...||. | . || . |. .| . | |
GrtGtfitldavldqaeaen.aidvynfitgvrqnrikmvqvaeqyqfiydalletfv
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 220-470 | 5.1e-22 | 72.9 | In-house | 26-289 (305) | alignment | ||
Range on Protein: 220-470
Range on HMM: 26-289/305.0
AVNEFEKVSGYLPPHISKNHFVSN------MDKNRFVDVICMDHSRVKLTD---SSYIHANWVD--LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVL
.|| ... | | .... | .| . |||. || | |.| ||| . | |||||.| . |. | .| || .| .|| |.|..|.. ..
lreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqiv
LIMTDGEFNKFGGNSVFPQNQDF---LKFEDRFIRVGEFKQVELGKGWNLKVLSVSN-GTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHP
.. | |. .| | || | | .| .. .| .. | | . .. .|| .| .. | .| |
mlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk..vp
PVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| .| ||.|| | . ...| | . . .|. | .|.|| |. .. .. ...
ivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 242-482 | 1.3e-21 | 71.7 | In-house | 47-299 (305) | alignment | ||
Range on Protein: 242-482
Range on HMM: 47-299/305.0
SNMDKNRFVDVICMDHSRVKLTDS---SYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFP-QNQDFLKFED
. .|||. || |.|. |||| . |||||.| . .|. | || || .| .||| | ...|.. .... | |. ...| |.||.
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee
RFI----RVGEFKQVELGKGWNLKVL----SV-SNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYtDGhPPVYMSMSGCGRAGTFALFETAHM
. .. ..... | . || . |. . . .|. .|| .|. | .. | | | | .| ||.|. ..|
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps.kg.pivvhcsagigrtgsvvmleyild
SLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEE
| . | . | | .|. | |.| |. |. .| .... ... ...|.|
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevke
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 235-470 | 2.8e-21 | 70.8 | In-house | 39-278 (287) | alignment | ||
Range on Protein: 235-470
Range on HMM: 39-278/287.0
ISKNHFVSNMDKNRFVDVICMDHSRVKLTD--SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDf
. | .| ||||. ... | || | . || | ..| ..||| |... |...|| .||..| |.... .... . | .. .|...
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.
LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYKNWP-HGSIPSDVKQIWQVQSYLR-KYTDGHPPVYMSMS-GCGRAGTFALFETAHMS
. . . |.. . .. . .|.| .. . | .. ... ||. .| ... . ... . .. |. .. . | . ||...| .|.
vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink
LHNEqPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
..| ..... |.. | . .||| .|. .. .. |..
ckte.GviDvfqvlksqriqkpgsvqtveqykfindivleyl
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 240-471 | 7.3e-21 | 69.3 | In-house | 41-278 (315) | alignment | ||
Range on Protein: 240-471
Range on HMM: 41-278/315.0
FVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ-NQDF
|. |||. ... .|..|||| || || | . . | | .| || . .|||.|....|. . .. | .| . .|. . |
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads
LKFEDrfIRVGEFKQVELGKGWNLKVlSVSNGTYKTFIHVHHYKNWPHGSIP----SDVKQIWQVQSYlrKYTDGHPPVYMSMSGCGRAGTFALFETAhM
.| |.| .. . | . |. . .. . . .....||. .. | .| | .|.. . .. .. . ..| ||.| . . .
vefGs..ikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad..ngkkefsllvhcsaGvGrtGvvisidev.v
SLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
. ... |... . ..|.|. | . || ... .| . |..|
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 238-470 | 8.3e-21 | 69.0 | In-house | 51-292 (297) | alignment | ||
Range on Protein: 238-470
Range on HMM: 51-292/297.0
NHFVSNMDKNRFVDVICMDHSRVKLTD------SSYIHANWVDLNSSKKA--ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ
. |..||| .|. |||||||.. | || | . . ... | || ||..| .|||||. .| . .. . . | . . .|..
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG
DF--LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGtyKTfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGH--PPVYMSMSGCGRAGTFALFETA
.| ... . . | . . || | |. .| . |. ||. ..|. | . . . . | | | | ...|.||.|.. | .
sevyhiyevhlvsehiwcddylvrsfylknlqtset..rt.vtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv
HMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| . .... || .|. | . |. .|| ...| .|| |
lnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 242-471 | 8.3e-21 | 68.6 | In-house | 42-277 (515) | alignment | ||
Range on Protein: 242-471
Range on HMM: 42-277/515.0
SNMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ-NQDFLK
| |||. ... .| .|||| .| |. | . .. | | .| |. . .|||........ . .. | .| .|. | .|
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk
FEDrfIRVGEFKQVELGKGWNLKVLSVSNGTYKTfIHVHHYKNWPHGSIPS----DVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAhMSL
| |.| . | |. . . ..| . .|...||. .| .| | .|.. .|| || . ..| ||.| . . ..
fGs..ikvelvsleactggikrkltvlkgddsrt.vtqfhfteWPdkGvpkhtssllklikevkadhgqyt..hpliihcsaGvGrtGvvisidsv.vah
HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
.. .... . ..|.|. | . || |.. .| . |..|
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 263-467 | 2.4e-20 | 68.5 | In-house | 10-170 (176) | alignment | ||
Range on Protein: 263-467
Range on HMM: 10-170/176.0
TDSSYIHANWVDLNsskKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKfedrfirvgefkqvelgkgwnlkvlsvsn
|..||.||... . . | || || .| ||..|. ...|..|. .... |..... .|. ...
ldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................
gtyktfihVHHYKNWPHGSIPSDvKQIWQVQSYLRKYTDGHPPVY-MSMSGCGRAGTFALFEtahmsLHNEQPSLNMVKCLENVRNGRL-HSVQNLSQFS
... .|| ...|.. ...... ..|.. . . ||. . |.||.||... | . |.. ..|. ||. | ..||. .|
........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqtpeQyr
VVYTLIA
.| .
flyefel
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 214-470 | 3.9e-20 | 66.7 | In-house | 16-279 (439) | alignment | ||
Range on Protein: 214-470
Range on HMM: 16-279/439.0
KDDANIAVNEFEKVSGYLPPHISKNHFVS---NMDKNRFVDVICMDHSRVKL------TDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQK
|.. .| ..|||.. |.. . ... . |||. || .||.|| | | || ||... | | || | .|. |||...|..|
knkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk
ikCVLLIMTDGEFNKFGgnsVFPQNQDFLkFEDRFIRVGefKQVELGK--GWNLKVLSVSNGTYK-TFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT
.| ..| .. . .| ... . | .|| ...|| . .||. . | | . || ||. .|.. . . .
..tvtivmltnlvesyk...ywpsdaevc.ygdiavrvd..rnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan
D---GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
| | | .| ||.|| .. | |. |. ... .. .|. | . ||.| |. ..| . | .
dkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 234-463 | 4e-20 | 66.7 | In-house | 41-279 (301) | alignment | ||
Range on Protein: 234-463
Range on HMM: 41-279/301.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLTDSS---YIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQN-
|| . . . ||.|. | | .. |.. . |||||.. . ... | || ||. |. ||| |.. ... . .. | .. .. .|..
hitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki
QDFLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSNGTYK----TFIHvHHYKNWPHGSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFET
.. |. . |.. . ... | | . . | | . | | | .| . |..|.. .| ..... ..| .| | .| ||. .| |
sekldigrfkikiknkeli.lnkkiskrtlevedstgkfatrtvth.yqysewtdrgvPkshaelfdlmelvkkse..kPivvhcsaGiGrsvafigtey
AHMSLHNeQPSLNMVKCLENVRNGRLHSVQNLSQFS-----VVY
... .| ... . |...|. | ..||. ||. ||
larevea.dptieltealkhlrehrwngvqtnsqlywmtlGtvy
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 234-470 | 1.7e-19 | 64.9 | In-house | 24-259 (267) | alignment | ||
Range on Protein: 234-470
Range on HMM: 24-259/267.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLTDS--SYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfgGNSVFPQNQD
||. | ..||. |.. |..|| | .. || | .|. |.| |.|| ||. | .||...|.|||. . |... .. | |. .
tisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdni..rlfwPPkmgq
FLKFEDRFIRVGEFKQVELGKGWNLKvLSVSNGTYKtFIHVHHYKNWPHGSI-PSDVKQIWQVQSYLRKYTDGHPPVYMSMSGCGRAGTFALFETAHMSL
|..| . |. . . |. | . | . . . ...||.| . .| .. . . . ..| | | ||.||| .. .
akkyqdltvehslekeendyqiitle.lkfknesah.nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera
HNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHV
.|. ... . | ..|. | |. . .. .. |.||.
kteg.vsdifdflrkirsqriglvdtkeryiyihellaeya
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 264-463 | 2.7e-19 | 65.0 | In-house | 4-154 (172) | alignment | ||
Range on Protein: 264-463
Range on HMM: 4-154/172.0
DSSYIHANWVDLNSSK-KAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDgefnkfggnsvfpqnqdflkfedrfirvgefkqvelgkgwnlkvlSVSN
.| ||.|...||. . | || ||..| .|||.|. ...|.... ... .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp
GTYKTFIHVHHYKNWPHGSIPsDVKQIWQVQSYLRK---YTDGHPPVYMSMSGCGRAGTFALFETAHmslhneqPSLNMVKCLENVRNGRLHSVQNLSQF
.. .. ..| .|| .. | . ...... ..... .|.| . . |.||.||... . .|.. .... ||. | ..||| ||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy
SVVY
.|
rfly
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 264-469 | 4.4e-19 | 64.6 | In-house | 3-224 (272) | alignment | ||
Range on Protein: 264-469
Range on HMM: 3-224/272.0
DSSYIHANWVDLNSS----KKAILTQLPLSHTASDFWQMiIDQKIKCVLLIMTDGEFNKFGGNSVFP-----------QNQDFLKFEDRFIRVGEFKQVE
|.||.|..|. . . .. .... || .|| |||.. ...||... .... | .... . | . . . .... .... .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll
LGKGWNLKVLSVSNGTYKTFIHVHHYKNWPHGSIPSDVkqIWQVQSYLRKytdGHPPVYMSMSGCGRAGTFALFETAHmSLHNEQPSLN--------MVK
..| . ... . ... || .|| ..|.. . .. ..|.. |.| .. ..|..| ||... ... .. . .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlylee
CLENVRNGRLHSVQNLSQFSVVYTLIAEH
..| .| | ..||. |. .| ..|
aveelraqrpgavqteeqylflyeallel
|
|||||||||
PTPc_DSPc_SM00012 | 369-468 | 4.7e-19 | 63.9 | In-house | 2-105 (105) | alignment | |||
Range on Protein: 369-468
Range on HMM: 2-105/105.0
IHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD----GHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYT
... ||..||. ..|.... | .. ...| . ..| | .. |.||.|||.........|..|. .... .... .|. | ..||.. |....|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
LIAE
..|
alle
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 221-312 | 3.8e-18 | 60.1 | In-house | 30-127 (310) | alignment | ||
Range on Protein: 221-312
Range on HMM: 30-127/310.0
VNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLT-D----SSYIHANWVDLNSSKKA-ILTQLPLSHTASDFWQMIIDQKIKCVLLIMT
|... |. . .. . . .| |||. ||.|.| |||||. | |||||.| | ... | .| || || |||.||.... . .||.
vkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck
|
|||||||||
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 234-483 | 4.1e-18 | 60.1 | In-house | 34-289 (312) | alignment | ||
Range on Protein: 234-483
Range on HMM: 34-289/312.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLT--DSSYIHANWVDLNSSKK-AILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD
|. | ||. .. | | | |. . |||||.| . . . . || || |.. |||. . ...|. . | .
dsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg
FLKFEDRFIRVGEFKQVELGKGW-------NLKVLSVSNGTYKTFIHvHHYKNWPHGSIPSDVKQIWQVQSYLRKytDGHPPVYMSMSGCGRAGTFALFE
|...|| . ..|.| |||. . | . | . . || .| . .. | ..| | .| . .| ||.||.|| |
fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnh.yqwaswpdhgmpdscdtalrllsavkk..dkkpviahcsagvgrtgtlalie
TAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVEEQ
. .| . |. . . .|. | ||. . |. . . | . .|. |.. .|
smiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqew
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 240-471 | 2.2e-17 | 57.6 | In-house | 42-237 (392) | alignment | ||
Range on Protein: 240-471
Range on HMM: 42-237/392.0
FVSNMDKNRFVDVICMDHSRVKL------TDSSYIHANWV-DLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMT--DGEfnkfggnsvfpqnqd
|. |||. ... .| .|||| .|| |. | .. ... | | .| | . . .|||.|. .... . .. .|.
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............
flkfedrfirvgefkqvelgkgwnlkvlsvsNGTYKTFIHVHHYKNWPHGSIP----SDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAH
.| . . .|. .|| .| | .| | .|.. .|| || . .| ||.| ..
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqyt..hpliihcsagvgrtgvvisidsvv
mSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVL
. .. ..... . |.|. | . || |....| . | .|
.ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 211-468 | 7.4e-17 | 56.0 | In-house | 6-275 (287) | alignment | ||
Range on Protein: 211-468
Range on HMM: 6-275/287.0
ETLKDDANIAVNEFEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----SSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKI
||| . |. . . | . . . . .. |||. ||. .|..|| |. |.|| ||.| . .. | .| |.. | |||.......
rrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrs
KCVLLIMTDGEFNKFGGNSVFPQNQDFLKFEDRFIRVgeFKQVELGKGWNLKVLSVSNGTYK--TFIHVHHYKNWPHGSIPSD----VKQIWQVQ---SY
|... . | . .|... .. . . ... . . . | . . . .. .. .|| .... .. . .|.
asvitmtreveearlkcykywPerevPmrvGGysvvl..ldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel
LRKYTDGHPPVYMSMSGCGRAGTFaLFETAHMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAE
|. .. |.| | ||.|.. | . .| .. ... . . .|. | || |. ..| ..
ardasevGPlvvhddvGiGrsGil.latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 219-472 | 3e-16 | 54.2 | In-house | 10-268 (283) | alignment | ||
Range on Protein: 219-472
Range on HMM: 10-268/283.0
IAVNEFEKVSgyLPPH-ISKNHFVSNMDKNRFVDVICMDHSRVKLTDS--SYIHANWVD----LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIM
. . ....| .|. . | |||. ... .| ||.| .|| | .. . .|| | .| || .| |||.|. |.|| .....
lfrevlkrls..vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt
TDGEFNKFGGNSVFPQNQdFLKFEDRFIRVGEFKQvelGKGWNLKVLSVSNG-TYKTFIHVHHYK--NWPHGSIPSDVK---QIWQVQSYLRKYTDGhpP
| .. .|.. .. . . . . . . | | . . . |. . . ||. .| . . . . .. .|.| .. .| |
klqedlrikCsqyWPkrG.sedyGeftvtlrkett...snsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkg..P
VYMSM-SGCGRAGTFALFETAhMSLHNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIAEHVLG
. . .| ||...| .. . . ... . ....|. | ||.| |. .|..|. |. |
ivvhCstgiGrtavfiaasas.vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalc
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 265-463 | 1e-15 | 53.3 | In-house | 2-163 (174) | alignment | ||
Range on Protein: 265-463
Range on HMM: 2-163/174.0
SSYIHANWVDLNS-SKKAILTQLPLShtasdFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQnqdflkfedrfirvgefkqvelgkgwnlkvlsvSNG
|.||.|...||. ... |..| ||. ||.|. ...|..|. .. | .... .|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre
TYKTFIHVHHYKNWPHGSIPSDVKqIWQVQSYLRKY---TDGHPPVYMSMSGCGRAGTFALFETAHMSLHneQPSLNMVKCLENVRNGRLHSVQNLSQFS
.. ... ..| .|| .. |.. . .... ...... .|.| . . |.||.||... .. |. .. . .. . .|. | ..||. ||.
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr
VVY
.|
fly
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 278-463 | 1.1e-15 | 53.1 | In-house | 8-143 (152) | alignment | ||
Range on Protein: 278-463
Range on HMM: 8-143/152.0
SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFpqnqdflkfedrfirvgefkqvelgkgwnlkvlsvsngtyktfihVHHYKNW
....| || |...|..|||.|. ...|.... .... |..|.. . . ... .|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw
PHGSIPSDVKQIWQVQSYLRK--YTDGHPPVYMSMSGCGRAGTFALFETAHmslhneqPSLNMVKCLENVRNGRLHSVQNLSQFSVVY
| .. |.. . .. ..| .|.| . . |.||.||... . ... .... ||. | ..|.| .| .|
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 243-464 | 8.6e-15 | 49.5 | In-house | 7-234 (239) | alignment | ||
Range on Protein: 243-464
Range on HMM: 7-234/239.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWV-DLNSSKKA-ILTQLPLSHTASDFWQMIIdQKIKCVLLIMTD-GEFNKFGGNSVFPQNQDflK
| |||. ... ||||| | | || |... | . | || | || .. .. |||.|. |. .||....| | | .|.. |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmw.qerrcvivmltglieghkkkchqywpdsts..k
FEDrfIRVGeFKQVELGKGWNLK--VLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFEtAHMSL
. . .|| ... |. . .. |.| | . ... .|. || .| . .. . | . .| | .| ||.|.| . . | .
ycn..lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid.amlrq
HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYT
..| ...... .. .|. | | || |. ...
akkqktvdifnyvkairedrphmvqtseqyvfihl
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 243-463 | 9.3e-15 | 49.4 | In-house | 8-234 (239) | alignment | ||
Range on Protein: 243-463
Range on HMM: 8-234/239.0
NMDKNRFVDVICMDHSRVKLT------DSSYIHANWV-DLNSSKKA-ILTQLPLSHTASDFWQMIIdQKIKCVLLIMTD-GEFNKFGGNSVFPQNQDflK
| |||. ... ||||| | | || |... | . | || | || .. .. |||.|. |. .||....| | | .|.. |
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmw.qerrcvivmltglieghkkkchqywpdsts..k
FEDrfIRVGeFKQVELGKGWNLK--VLSVSNGTYKTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYT--DGHPPVYMSMSGCGRAGTFALFEtAHMSL
. . .|| ... |. . .. |.| | . ... .|. || .| . .. . | . .| | .| ||.|.| . . | .
ycn..lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid.amlrq
HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVY
..| ...... .. .|. | | || |. ...
akkqktvdifnyvkairedrphmvqtseqyvfih
|
|||||||||
subfamily_egg_pd | Subfamily egg | 242-473 | 6.8e-14 | 46.2 | In-house | 39-276 (307) | alignment | ||
Range on Protein: 242-473
Range on HMM: 39-276/307.0
SNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNS-SKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKfgGNSVFPQN-QDFLK
|..| | | | | ||||| .|||| |. . . ||.| || | |||.|. .... .... . | .. . .|. .| |.
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeser..ceyywpkaesdslv
FEDRFIRVGEFKQVELGK-GWNLKVLSVsNGTYKTFIHVHHYKnWPHgSIPSDVKQIWQVQSYLRKYTdgHPPVYMSMSGCGRAGTFALFETAHMSLHNE
. .|. .| . ... | . |. . .. |.. . ||| .| ||. . .| | .. |. .|.|. |.| .||
tvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwq.gdv.nnssdvysplrvlrklrnls..kpvvvqdilGvskaatlvaieiallsllrG
qPSL--NMVKCLENVRNGRLHSVQNLSQFSVVYTLIA---EHVLGN
| . .. .| | ||. .. || |.. |.|.
.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigs
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 256-466 | 7.5e-14 | 47.2 | In-house | 3-167 (178) | alignment | ||
Range on Protein: 256-466
Range on HMM: 3-167/178.0
DHSRVKLT------DSSYIHANWVDLNsskkAILTQLPLshtaSDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDflkfedrfirvgefkqvel
|..||.|. | ||.|.... . .|..|| .|..... ...|.... . .. | .... . .|.. .
drtrvllsnleglersdyinaseilpg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...................
gkgwnlkvlsvsngtyktfIHVHHYkNWPHGSIPSDVKQIWQVQSYLRKY--TDGHPPVYMSMSGCGRAGTFALFETAHMSlhneqpSLNMVKCLENVRN
|...|. ..| .. |. ...... ..... ..|.| . . | ||.||... .. .|.. ...| ||.
...................iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvre
GRLhSVQNLSQFSVVYTLI
| |.| .| .| .
rRp.ivpnpgqlrqLyefe
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 258-481 | 1e-13 | 44.6 | In-house | 91-320 (346) | alignment | ||
Range on Protein: 258-481
Range on HMM: 91-320/346.0
SRVKLTDSSYIHA---NWVDLNSSKKAILTQLPLSHTA---SDFWQMIIDQKIKCVLLIMTDGEFNKfGGNSVFPQNQDFLKF-EDRFIRVGEFKQVELG
|| . .|.| .| .. .| |..||| . ||| || ...|. | |.. | ... |.| ... .. ||
srrmacvpayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkn.tttslfndenggyqytgkmfinnrradvsgdp
KGWNLKVLSVSNGTyKTFIHVHHYKNWPHGSIPSD----VKQIWQVQSYlrKYTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEqPSLNMVKCLENVR
| . ..|| | .|||. | | | .| | | | | .|. ||||| .| | | | |... . |..
keytievlpegnsd.svicqvhhhapwkhlqqppktlpiikmihqflse..kqvqnagvcvvslfgcgracsfigalyainqlnng.iepniceimknik
NGRLHSVQNLSQFSVVYTLIAEHVLGNGIGKKDVE
. | .|. ..|.. .|... ... |||.
qqrpggvesfaqyasiyaivfdyiarkrggkkapv
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 243-466 | 1.6e-13 | 45.4 | In-house | 3-235 (237) | alignment | ||
Range on Protein: 243-466
Range on HMM: 3-235/237.0
NMDKNRFVDVICMDHSRVKLT----DSSYIHANWVDL--NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDFLKFED
| |||. .....||||| | .| || |.... . || | .| || . |||||. ..| .... | |. .|. .. .
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv
rfIRVGEFKQVELGKgWNLKVL-SVSNGTYK--TFIHVHHYKNWPHGSIPSDVKQIWQVQSYL----RKYTDGHPPVYMSMSGCGRAGTFALFEtAHMSL
. | |. |. . .. | . ..| | .|| ... ||. .| . . . . .. .. | . .| ||.| | . . | .
..ltvslkkkeefsd.ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid.amlrq
HNEQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
.|. ... . . .. . | . .| |. ... |
akekkvvdiynyvysieedrpyiiqtkdqyvfihqti
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 265-465 | 2.7e-13 | 45.3 | In-house | 3-148 (151) | alignment | ||
Range on Protein: 265-465
Range on HMM: 3-148/151.0
SSYIHANWVDLNsskkAILTQLPLShtasDFWQMIIDQKIKCVLLIMTDGEFNkfGGNSVFPQNQdflkfedrfirvgefkqvelgkgwnlkvlsvsngt
|.||....|. . .... ||. ||.... ...||... .... | . . .|...
sdyinfsyvtgg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................
ykTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKyTDGHPPVYMSMSGCGRAGTFALFETAHMSlhneqpsLNMVKCLENVRNGRLHSVQNLSQFSVVYT
.. .. .|| ..| ... .. ..|.. ....| . ..|.|| ||... .. ... ..|| .| | ..|| || ...
..ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflfqlf
L
a
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 235-393 | 4.7e-12 | 40.4 | In-house | 25-190 (297) | alignment | ||
Range on Protein: 235-393
Range on HMM: 25-190/297.0
ISKNHFVSNMDKNRFVDVICMDHSRVKL----TDSSYIHANWVDLN---SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQ
| . | . |||. |.. .| .|||| |.. || |..| . . | ||.| ||| | |||... .| .. . .. | . .|.
fssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywps
NQ-DFLKFEDRFIR-----VGEFKQVELgkgWNLKVLSVsnGTYKTFIHVhHYKNWPHGSIPSDVKQIWQVQ
. . || | . ||..| | .|... . || . .|| .|||.... . |
vvqerlkagdvvveflsstsdefdrvil...telqliyr..sesrvvrhv.qflswpdhGvpsdledlvrfq
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 234-322 | 7.7e-12 | 39.7 | In-house | 38-132 (418) | alignment | ||
Range on Protein: 234-322
Range on HMM: 38-132/418.0
HISKNHFVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGN
|. | |||. ... ..|.||.| | || ||..| |. | || || | .|||.|. ... . .... . | . .
etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcd
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 263-464 | 1.2e-11 | 39.3 | In-house | 44-253 (290) | alignment | ||
Range on Protein: 263-464
Range on HMM: 44-253/290.0
TDSSYIHANWVDLNSSKKAILTQLPLSHT-------ASDFWQMIIDQKIKCVLLIMTDGEFNK----FGGNSVFPQNQD-FLKFEDRFIRVgefKQVELG
. ||||| | . . |||| |. .. .|| |. . |.| | . | .. | . .|.. . |||.. .. |. |
fnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC...kskeke
KGWNLKVLSVSNGTYKTFIHVHH-YKNWPHGSIPSDVKQIWQVQSYLRkyTDGHPPVYMSMSGCGRAGTFALFETAHMSLHNEQPSLNMVKCLENVRNGR
.. . . | | . . | |. .|.| . ... | | . .. .... . . | . . | | ..| . . . . . |..... |...|. |
ddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqr
LHSVQNLSQFSVVYT
. ... ... |
alaitsalelafvda
|
|||||||||
subfamily_Cele-PTP-12_pd | Subfamily Cele-PTP-12 | 237-310 | 7.7e-11 | 36.0 | In-house | 28-107 (332) | alignment | ||
Range on Protein: 237-310
Range on HMM: 28-107/332.0
KNHFVSNMDKNRFVDVICMDHSRVKLTD----SSYIHANWVDLNSSKKA-ILTQLPLS-HTASDFWQMIIDQKIKCVLLI
..|. ||| || . |.|||||.|. . |.||| | | | |..| |. || ||.|. ..| .|..
ydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 236-467 | 1.1e-10 | 35.8 | In-house | 44-290 (301) | alignment | ||
Range on Protein: 236-467
Range on HMM: 44-290/301.0
SKNHFVSNMDKNRFvdvICMDHSRVKLTDSSYIHANWVDLNSS-KKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ----D
.... ....|.||. | .....|. .|| |...| |. || | .| |. .| |||..|...| .. .. | | . .|. . .
nrfknitvyddnri...ilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee
FLKFEDRFIRVGEFKQVeLGKGWNLKVLSVSN-GTYKTFIHV-----------HHYKNWPHGSIPSDVKQIWQVQS--YLRKYTDGHPPVYMSMS-GCGR
| .|. .. . . . . |.|. .|| | . ..| . .||. . . . . || |. | || | . .|
fgpftvtlvneqvyPdf.virqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsr
AGTFALFETAHMSLHNEQpSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLIA
.|.. . . | .... . || . |. | |.. .| |
sGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvid
|
|||||||||
subfamily_eak_pd | Subfamily eak | 203-376 | 1.7e-10 | 34.8 | In-house | 11-186 (332) | alignment | ||
Range on Protein: 203-376
Range on HMM: 11-186/332.0
TKWKLVAQETLKDDANIAVNEFEKVSGYLPP-HISKNHFVSNMDKNrFVDVICMDHSRVKLTDS-----SYIHANWVDLNS-SKKAILTQLPLSHTASDF
|| |. .. . . | .| ... | . ||. . ....| |... |. |.|| | || | .... .| ||| .. |
ekwilinknhiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfaf
WQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQ-DFLKFEDRFIRVGEFkqVELGKgWNLKVLS--VSNGTYKtfihVHHYKN
|||...|| ... .. | | . . ||.. . ||| . || |. .. . . | . | |.. |.|||
wqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrni.letrllelskGnethr....vlhykv
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 241-317 | 1.8e-10 | 35.1 | In-house | 45-142 (350) | alignment | ||
Range on Protein: 241-317
Range on HMM: 45-142/350.0
VSNMDKNRFVDVICMDHSRVKLT--------------DSSYIHANWVDLN-------SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFN
| . |||..... .|||||| . || ||.. |. .. | | || || | ||...|. |.| .| . .| |.|
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 224-311 | 1.5e-09 | 31.9 | In-house | 18-117 (347) | alignment | ||
Range on Protein: 224-311
Range on HMM: 18-117/347.0
FEKVSGYLPPHISKNHFVSNMDKNRFVDVICMDHSRVKLTD-----------SSYIHANWVDL-NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIM
|....| |.... . . ...||| || .| .|| |. .|| | . . |.||. |||| || .| |||.|. |. |. |.
denlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
|
|||||||||
subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 286-466 | 7.4e-09 | 30.0 | In-house | 39-217 (255) | alignment | ||
Range on Protein: 286-466
Range on HMM: 39-217/255.0
LplshTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQD-FLKFEDRFIRVGEFKQVELGKGWNLkvLSVSnGTYKTFIHV--HHYKNWPHGSI
| | |.|.|. .| . | .. | .. .| || ..| ||..| . . . . . . .. .| | | | ..|| |.
l....tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei..tstl.gekkkthtvkhysykGWiekna
PSDVKQIWQVqsyLRKYTDGHPPVYMSMSGCGRAGTFALFETAHM----SLHN-EQPSLNMVKCLENVRNGRLHSVQNLSQFSVVYTLI
| . ..| .. |. .| .. | . .| ||. .|.| | .. ||.. | |. .. ||..|. | .... |.. ..
Pelareilni...lkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 359-466 | 7.4e-09 | 31.0 | In-house | 38-139 (145) | alignment | ||
Range on Protein: 359-466
Range on HMM: 38-139/145.0
SVSNGTYkTFIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTDGHPPVY-MSMSGCGRAGTFALFETAHMslhneqPSLNMVKCLENVRNGRLHSVQNLS
| .. . .. ..| .|| ..|.. ...... ..... . . ||. . |.||.||... .. .... ..|| ||. | ..|.| .
selelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpg
QFSVVYTLI
|. .| ..
qlrflyefe
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 356-464 | 1.3e-08 | 30.2 | In-house | 48-139 (144) | alignment | ||
Range on Protein: 356-464
Range on HMM: 48-139/144.0
KvlsvsngtyktfIHVHHYKNWPHGSIPSDVKQIWQVQSYLRKYTD-GHPPVYMSMSGCGRAGTFALFETAHmslhnEQPsLNMVKCLENVRNGRLHSVQ
.. ... .|| ..|.. ... .. ..... . |.| . . |.||.||... . .. |.. ..|. ||. | ..|.
e............giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavp
NLSQFSVVYT
| .|. ..
npgqlrfLle
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 237-383 | 2.1e-08 | 28.1 | In-house | 89-237 (244) | alignment | ||
Range on Protein: 237-383
Range on HMM: 89-237/244.0
KNHFV-SNMDKNRFVDVICMDHSRVKLTDS----SYIHANWVD-LNSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFnkfggNSVFPQNQD
|. | .| ||| . .| .|| |. . .|| | .| | . . |||| ||. |. |||.|....... .... . | . .|. .
kdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep
FLKFE-DRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFiHVHHYKNWPH-GSIP
. .| | . . . . | ||.. | | ..... . ||| |. |
lewyeeditvtltdrdefknikasnleiesdmneshqal.tmfqisnwpsdgttp
|
|||||||||
subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 256-313 | 1.1e-07 | 26.2 | In-house | 6-61 (130) | alignment | ||
Range on Protein: 256-313
Range on HMM: 6-61/130.0
DHSRVKltDSSYIHANWVDLN-SSKKAILTQLPLSHTASDFWQMIIDQKIKcVLLIMTD
. ||.. . ||.|..| | ... .||| ||. |. |||.|.... . ||...
evsrlq..gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvn.vlvvlgs
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 240-389 | 2.1e-06 | 21.6 | In-house | 25-183 (319) | alignment | ||
Range on Protein: 240-389
Range on HMM: 25-183/319.0
FVSNMDKNRFVDVICMDHSRVKLT------DSSYIHANWVDLN--SSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGEFNKFGGNSVFPQNQDF
|. ||.|...|. . ..|| | . |..|..| . | .| .| ..||||... .|. . .. . | .| ..
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl
LKFEDRFIRVGEFKQVELGKGWNLKVLSVSNGTYKTFIHVHHYK-NWPHGSIPSDVKQI
. .|. | .. . . | . . . .. || .|.. .|.. . .
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaal
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 266-315 | 3.1e-06 | 20.7 | In-house | 91-143 (349) | alignment | ||
Range on Protein: 266-315
Range on HMM: 91-143/349.0
SYIHANWVDL---NSSKKAILTQLPLSHTASDFWQMIIDQKIKCVLLIMTDGE
|| ||.. | . || | || || | ||...|. ...| || . | |
dyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddke
|