Gene cdc-14 in Caenorhabditis elegans

Synonym: CELE_C17G10.4, cdc-14

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP044_AA protein Get Run
CeleP044_AA_14-175 phosphatase_domain Get Run
CeleP044_AA_194-352 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_CDC14_pd Subfamily CDC14 18-352 5.6e-154 506.8 In-house 4-327 (328) alignment 
Range on Protein: 18-352
Range on HMM: 4-327/328.0
TELLPNRLYFGCFPN-PDAIDKSDksvkktcFININNKFHYEPFYEDFGPWNLSVLYRLCVQVGKLLEVEEKRSRRVVLFCQDDgtgqyDKIRVNTAYVL
.|||..||||... . |.......       .........|| ||.||||.||.||||.||.. |.|. |||.|...||... |     .| |.|.|...
lelledrlyfatlrkkPkstselh.......yfsvddelkyenfyadfGPlnlavlyrycvklnkkLkseekaskkivlytsad.....skkranaalli

GAYLIIYQGFSADDAYLKVSSGETVKFVGFRDASMGSPQYLLHLHDVLRGIEKALKFGWLDFSDFDYEEYEFYERVENGDFNWIIPGKILSFCGPHNESR
|||..||. ..|..|| .....||..|| |||||.|| .| |.|.|||.|.||||..|.||..|||.|||| ||||||||||||.|.|.|...||||.|.
gayaviylkktaeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnwivPdkflalagPhnksk

EENGYPYHAPDVYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGL
.|.|||.|||. ...|||.|.|.|.||||.|.|||.|||.|||||.||||||||||||.|. ||........|..|||||||||||||||||..||.|..
ledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrf

TAGECMGWLRVCRPGSVIGPQQPYLIEKQKFCWSLS
|| |...|||.||||||||||| .|.|||. .|. .
taaeaiawlricrPGsvigpqqkfleekqaalwleg
0041856 (Phosphotyrosine protein) phosphatases II 181-352 5.8e-41 135.4 In-house 2-173 (182) alignment 
Range on Protein: 181-352
Range on HMM: 2-173/182.0
FDYEEYEFYERVENGDFNWIIPGKILSFCGPHNESREENGYPYHAPDVYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKF
.|...|. . ..... ... |  ... .. |...    .|.... .  ......|....|||.|.  .|........|. ...|.. |...|. ...|.|
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldf

IKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVIGPQQPYLIEKQKFCWSLS
|. | . .| |.|||.||.||||||.|...||..|... |.. ..| .|||.|| |.| ...  . ... | 
ieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
0038934 (Phosphotyrosine protein) phosphatases II 184-342 7.2e-40 132.1 In-house 4-167 (194) alignment 
Range on Protein: 184-342
Range on HMM: 4-167/194.0
EEYEFYERVENgdfnwIIPGKILSFCGPHNESREENGYPYH--APDVYFDYFREN--KVSTIVRLN--AKNYDASKFTKAGFDHVDLFFID-GSTPSDEI
.... ||||..     ||.|... |..|...| ... ....  .|. ...|....  |. ....|.   . ||...|.|||.....|.|.| |..||.||
drwlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

MLKFIKVVD-----NTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVigPQQPYLI
.|.|...||     ...| |||||||||||||||.|..... .|..| |.....| .|||..  |.| || 
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgai..pnqdyle
0049772 (Phosphotyrosine protein) phosphatases II 145-345 9.2e-39 129.4 In-house 68-267 (314) alignment 
Range on Protein: 145-345
Range on HMM: 68-267/314.0
GFRDASMGSPQYLLHLHDVLRGiEKALKFGWLDFSDFDYEEYEFYERVENGDFNWIIPGK---------------------ILSFCGPHnesreengyPY
.... .. .  |.    . ..  .. |. .. ||..... .|.....|..||.|......                     .|...|..         ..
pvsgsdyinasyvdgflkfIat.qgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.........ne

HaPDVYFDYFRenkvstivrlnAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVDN--TKGGVAVHCKAGLGRTGT-LIACWMMKEYGLTAGE
  .  ......              ||...|...|. .... . |||.|..|....|......  ..| |.|||||| ||||| ..|...|| .|... |
p.taadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvslee

CMGWLRVCRPgsvIGPQQPYLIEKQ
.. ..| .||   |.|.. ..   .
aledvrlkRp...inpnpgfieqle
DSPn Dual specificity protein phosphatase, N-terminal half 19-170 1e-38 123.2 Pfam-A 2-141 (141) alignment 
Range on Protein: 19-170
Range on HMM: 2-141/141.0
ELLPNRLYFGCFPNpdaidkSDKSVKKTCFININNKFHYEPFYEDFGPWNLSVLYRLCVQVGKLLEVEEKRSRRVVLFCQDDGtgqydKIRVNTAYVLGA
||...|||| .. .      . |. ..| ...|.....|||||.|||| ||...|| ||.. |.|. .|......||... |      | |.|.|. .||
eliedrLyfvslkk......kpkktenthyfsiDeelvYepfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytslde.....kkranaalLiga

YLIIYQGFSADDAYLKVSSGEtVKFVGFRDASMGSPQYLLHLHDVLRGIEKA
|..|... |...|. ...|.|  ... |||||.|. .| |...|.|.|.|||
Yavivlklspeealkplesve.psllpFrDAsygestyeltildclkglekA
0048567 (Phosphotyrosine protein) phosphatases II 192-349 3.8e-36 118.7 In-house 2-138 (157) alignment 
Range on Protein: 192-349
Range on HMM: 2-138/157.0
VENGDFNWIIPGKILSFCGPHNESREENGYPYHAPD--VYFDYFREN---KVSTIVRLNAKnydaskftkagfdhvdlffidgstpsdeiMLKFIKVVDN
.||||...|||.... ...|. ... .| .... .|  ||.|.|...   ......|.. |                             . ||.|....
kengdlieiipdrlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilk.............................lnkflkilel

TKGGVAVHCKAGL---GRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVIGPQQPYLIEKQKFCW
... .||||||||   |||.|||.|.... .|.|. |....||..|||||..... ||. ......
agkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltl
0050432 (Phosphotyrosine protein) phosphatases II 138-342 1.2e-35 118.8 In-house 6-291 (308) alignment 
Range on Protein: 138-342
Range on HMM: 6-291/308.0
GETVKFVGFRDASMGSPQYLLHLHDVLRGIEKALKFGWLD------FSDFDYEEYEFYERVENGDFNW-------------------------------I
. ..... |||.|.    . |...|.|. .|||| .|.|.      .| ....||......||.|.|.                               .
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssk

IPGKILSFCGPHnesreengypYHAPDVYFDYFRENKVSTIVRLNAKNYD-----ASKFTKA---GFDHVDLFFI-------------------------
.| |.. . ||.          ..  . .. .. |..|..||.|.   ..     |  .      |. ... |..                         
lprkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdge

-------------DGSTPSD-EIMLKFIKVVDNT--KGGVAVHCKAGLGRTGTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPYLI
             |...|.. ||.|.|.. |...  .| ..|||.||.|||||.||....     ||.|... |.. .|| .|||.|..|.| ...
srtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0040438 (Phosphotyrosine protein) phosphatases II 156-342 3.7e-35 117.1 In-house 5-268 (317) alignment 
Range on Protein: 156-342
Range on HMM: 5-268/317.0
YLLHLHDVLRGIEKALKFGWLDFSDFDYEEYEFYERVENGDFNWII----------------------------------PGKILSFCGPHnesreengy
.||.| |.|..  .||. .. |. ......|...|..||.|.|..                                   . |.. . ||.         
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.........

pYHAPDVYFDYFRENKVSTIVRLNAKNYD------------------------ASKFTKAGFDHVDLFF-------------------IDGSTP-SDEIM
  .  . .. .. |..|..||.|.   ..                         | ...||. .  | .                    |...| | ...
.pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

LKFIKVVDNT----KGGVAVHCKAGLGRTGTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPYLI
|.|.. |..     .| |.|||.||.|||||.||...|     ||.|... |.. .|| .|||.|  |.| . .
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl
0043147 (Phosphotyrosine protein) phosphatases II 184-342 8e-35 115.5 In-house 2-153 (172) alignment 
Range on Protein: 184-342
Range on HMM: 2-153/172.0
EEYEFYERVENGDFNWiIPGKILSFCGPhnesreengyPYHAPDVYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKV
.|.. |..... |... || ... ..||            .  . ......|.....||.|.   ||...... |. .  | . |...|. |..|.|.. 
degsdyinasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflef

VDN-----TKGGVAVHCKAGLGRTGTLIACWMMKeYGLTAGECMGWLRVCRPGSVIGPQQPYLI
.|.      .| |.|||.||.||||||.|...|. .||.. |.. ..| .|||.|  |.| ...
idellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrfl
0048567 (Phosphotyrosine protein) phosphatases II 17-178 2.1e-34 113.0 In-house 7-156 (157) alignment 
Range on Protein: 17-178
Range on HMM: 7-156/157.0
LTELLPNRLYFGCFPNPDAidksdkSVKKTCFININNKFHYEPFYEDFGPWNLSVLYRLCVQVGKLLEVEEKRSRRVVLFCQDDGtgqydKIRVNTAYVL
|.|..|.|||| ..|...       |. ......|.....||.|. ||||.||..|||..... |.|.. |.........|  .      | | .||...
lieiipdrlyfallprlpk......slynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckagl.....kkrgrtatLi

GAYLIIYQGFSADDAYLKVSSGETvKFVGFRDASMGSPQYLLHLHDVLRGIEKALKFGWLDF
|.|||...||....|.  ..  .  ..| |||||..   | |.|.|||.|..|||..|.||.
gcYlilhlgftpeeaiaplrivrp.gsvpfrdasyllslynltlldvlyGllkAlelgfldl
0039614 (Phosphotyrosine protein) phosphatases II 144-342 2.9e-34 114.3 In-house 2-281 (297) alignment 
Range on Protein: 144-342
Range on HMM: 2-281/297.0
VGFRDASMGSPQYLLHLHDVLRGIEKALKFGWLDFSDFDY----EEYEFYERVENGDFNWII------------------------------------PG
. .|||...|... |.  |.| ..|||.....|.   ...    ..|......||.|.|...                                    . 
lplrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr

KILSFCGPHNEsreengypyhAPDVYFDYFRENKVSTIVRLNAKNYDASKF----------------TKAGFDHVDLFF---------------------
|.. . ||..|           .. .. ...|..|..||.|.  ...  |.                |  ...| | ..                     
kfIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqyt

--IDGSTP-SDEIMLKFIKVVDN------TKGGVAVHCKAGLGRTGTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPYLI
   |...| | |..|.|.. |..       .| |.|||.||.|||||.||...|     ||.|... |.. .|| .|||.|  |.| . .
gwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0044763 (Phosphotyrosine protein) phosphatases II 176-350 3.7e-34 113.3 In-house 2-172 (178) alignment 
Range on Protein: 176-350
Range on HMM: 2-172/178.0
LDFSDFDYEEYEFYERVENGDFNWIIPGKILSFCGPhnesreengypyhapDVYFDYFRENKVSTIVRLNAKNY------DASKFTKAGFDHVDLFFIDG
||.. .. ...| .||... ....|.|| .|. ..|                 ......|.....||.|.   .      |.  ...||. .. . . |.
ldrtrvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDh

STPS-DEIMLKFIKVVD----NTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVIGPQQPYLIEKQKFCWS
..|. .|..|.|.. ..    . .| |.|||.||.||.|||.|...||..||.. |.. ..| .||..    |. .|.| ... ..
gvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrllk
0043336 (Phosphotyrosine protein) phosphatases II 154-340 9.5e-34 112.5 In-house 5-267 (278) alignment 
Range on Protein: 154-340
Range on HMM: 5-267/278.0
PQYLLHLHDVLRGIEKALKFGWLDFSDFDYEEYEFYERVENGDFNWII----------------------------------PGKILSFCGPHNEsreen
 ..| .| ..|..  ..|. .. .. .|....|......||.|.|..                                   | |.. . ||..|     
kdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.....

gypyhAPDVYFDYFRENKVSTIVRLNAKN--------------------------------------------YDASKFTKAGFDHVDLFfiDGSTP-SD
      .. .. ...|..|.|||.|.                                               .|  ..|  .. ...    |...| | 
.....tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpesl

EIMLKFIKVVDN----TKGGVAVHCKAGLGRTGTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPY
...|.|.|.|..     .| |.|||.||.|||||.||....     ||.|... |.. .|| .|||.|  |.| .
sllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr
0045450 (Phosphotyrosine protein) phosphatases II 142-341 9.9e-34 112.9 In-house 4-295 (307) alignment 
Range on Protein: 142-341
Range on HMM: 4-295/307.0
KFVGFRDASMGSPQYLLHLHDVLRGIEKALKfGWLDFSDFDYEEYEFYERVENGDFNWI-----------------------------------------
..  |.|| ..  ..|| | | | |..|. .  .|.. .|.. ||......||.|.|..                                         
plslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

--IPGKILSFCGPHNEsreengypyhAPDVYFDYFRENKVSTIVRLNAKNYDASK------------------------------------------FTK
  .. |.. . ||..|           .. .. ...|..|..||.|.   .....                                          .|.
ydlkrkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtg

AGFDHVDLFF---IDGSTPSD-EIMLKFIKVVDN------TKGGVAVHCKAGLGRTGTLIACWMMKEYG--------LTAGECMGWLRVCRPGSVIGPQQ
 .. .  ...    |...|.. |..|.||. |..       .| |.|||.||.|||||.||...|....        ... |.. .|| .|||.|  |.|
esrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeq

PYL
 . 
yrf
0045098 (Phosphotyrosine protein) phosphatases II 168-343 1.5e-31 105.2 In-house 7-266 (278) alignment 
Range on Protein: 168-343
Range on HMM: 7-266/278.0
EKALKFGWLDFSDFDYEEYEFYERVENGDFNWII----------------------PGKILSFCGPHNesreengypyHAPDVYFDYFRENKVSTIVRLN
...|  ..  .. ..  |.... ...|.|.|..                       | | . . ||..          .  . ......|.....||.|.
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlp..........stvadfwrmlwelgitvivmlt

AKNYDA----------------------------------------------SKFTKAGFDHVDL-FFIDGSTPSDE---IMLKFIKVVDN---------
   ...                                              . ....|. |... .. |...||..    .|.... ...         
elvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

--------TKGGVAVHCKAGLGRTGTLIACWMMKEY---GLTAGECMGWLRVCRPG-SV-IGPQQPYLIE
         .| |.|||.||.||||||.|...|.|.   |... |.  .|| .||| .| .  |. .|.|
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflye
0049260 (Phosphotyrosine protein) phosphatases II 210-343 1.8e-30 101.0 In-house 6-143 (152) alignment 
Range on Protein: 210-343
Range on HMM: 6-143/152.0
GPHNESREENGYPYHAPDVYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVD-----NTKGGVAVHCKAGLGRTGT
....|     |.  .  . ......|....|||.|.   ...  ... .. .  |.. |...|.....|.|.  ..     . .| |.|||.||.|||||
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgt

LIACWMMKeYGLTAGECMGWLRVCRPGSVIGPQQPYLIE
|.|...|. .|... |.. ..| .|||.|. |.| ... 
lvaaylml.lgvsleeavalvrekRpgavpnpgqlrfly
0040439 (Phosphotyrosine protein) phosphatases II 185-341 1.2e-29 99.0 In-house 2-237 (249) alignment 
Range on Protein: 185-341
Range on HMM: 2-237/249.0
EYEFYERVENGDFNWII----------------------------------PGKILSFCGPHNEsreengypyhAPDVYFDYFRENKVSTIVRLNAKN--
||......||.| |..                                   . ... . || .|          . . ......|.....||.|.     
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvel

-------------------------------------------YDASKFTKAGFDHVDLFfiDGSTP-SDEIMLKFIKVVDN------TKGGVAVHCKAG
                                           || ...|  .. ..|.   | ..| | |..|.||. |..      ..| |.|||.||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaG

LGRTGTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPYL
.|||||.||...|     ||.|... |.. .|| .|||.|  |.| . 
vgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
0042113 (Phosphotyrosine protein) phosphatases II 186-342 1.2e-29 98.8 In-house 1-235 (245) alignment 
Range on Protein: 186-342
Range on HMM: 1-235/245.0
YEFYERVENGDFNWI----------------------------------IPGKILSFCGPHNEsreengypyhAPDVYFDYFRENKVSTIVRLNAKNYD-
|......||.|.|..                                  |..|.. . ||..|           .. .. ...|....|||.|.   .. 
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelg

------------------------------------------ASKFTKAGFDHVDLFFIDGSTPS-DEIMLKFIKVVDN-----TKGGVAVHCKAGLGRT
                                           ..... .. .  | . |...|. .|..|.|.. |..      .| |.|||.||.|||
rvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRt

GTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPYLI
||.||...|     ||.|... |.. .|| .|||.|  |.| . .
GtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl
0036282 (Phosphotyrosine protein) phosphatases II 189-343 2e-29 97.9 In-house 4-163 (174) alignment 
Range on Protein: 189-343
Range on HMM: 4-163/174.0
YERVENGDFNWIIPgKILSFCGPHNesreengypyhapdvYFDYFRENKVSTIVRLNAKNYDA------------SKFTKAGFDHVDLFFIDGSTPSDEI
|... . |...| | ... ..||..               ......|....|.|.|.  ...             . ... |. ...| . |...|...|
yinaspldlsyitp.rliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi

MLKFIKVVDNT-----KGGVAVHCKAGLGRTGTLIACWMMKEYGL-TAGECMGWLRVCR---PGSVIGPQQPYLIE
.|.|.| |..      .| |.|||.||.||||||.|...|. ..| .. . . ..| .|   ||.|. |.| . . 
llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly
0046846 (Phosphotyrosine protein) phosphatases II 189-343 6e-29 96.4 In-house 4-166 (176) alignment 
Range on Protein: 189-343
Range on HMM: 4-166/176.0
YERVENGDFNWIIPGKILSFCgphnesreengyP-------YHAPDVYFDYFRENKVSTIVRLNAK--------NYDASKFTKAGFDHVDLFFIDGSTPS
.......|...|... ||. .            |       ..    ......|......|.|.           .. . ..|.|. .  | . |...|.
rllgldldldyinanlilgsr............piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpd

DEIMLKFIKVVDNTK---GGVAVHCKAGLGRTGTLIACWMMKE-YGLTAGECMGWLRVCRP-GSVIGPQQPYLIE
.|..|.... ...     | |.|||.||.||||||.|.....  .||.. |.. ..| .|| |.|  |.| . ..
lelllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrfly
0051082 (Phosphotyrosine protein) phosphatases II 196-342 6.4e-29 95.9 In-house 7-145 (151) alignment 
Range on Protein: 196-342
Range on HMM: 7-145/151.0
DFNWIIPGkILSFCGPHNesreengypyhapdVYFDYFRENKVSTIVRLNAKN---YDASKFTKAGFDHVDLFFIDGSTPSD----EIMLKFIKVVDNT-
.|... .| .. . ||..               ......|....||| |. .    |... ....|...... ..| ..|.     ...|.|....... 
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

KGGVAVHCKAGLGRTGTLIACWMMKeYGLTAGECMGWLRVCRPGSVIGPQQPYLI
.| |.|||.||.||||||.|...|. .|... |.. ..| .|||.|. .|| ...
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfq
0037934 (Phosphotyrosine protein) phosphatases II 193-340 1.8e-28 95.1 In-house 35-232 (243) alignment 
Range on Protein: 193-340
Range on HMM: 35-232/243.0
ENGDFNWIIPgKILSFCGPHNESREEngypyhAPDVYFDYFRENKVSTIVRLNAKN------------------------------------------YD
 |... .. | ..  ..||..|. |.      ..  ..... |.....|| |.                                             .|
inanliyvtp.rliatqgPlpetved......dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenld

ASKFTKAGFDHVDLFFIDGSTPS-DEIMLKFIKVVD------------NTKGGVAVHCKAGLGRTGTLIACWMMKEY-GLTAGECMGWLRVCRPG-SVIG
....|. .. .  | . |...|.  |..|.|.. |             ...| |.|||.||.||||||||...|... |... |.. .|| .||| .|  
lddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqt

PQQPY
|.| .
psqyr
PTEN_1 193-345 6.3e-27 89.7 In-house 21-188 (196) alignment 
Range on Protein: 193-345
Range on HMM: 21-188/196.0
ENGDFNWIIPGKILSFCGP-HNeSREENGYPYHAPDV--YFDYFRENKVSTIVRLNAK------NYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKV
... ... | ..   .. | .    .|. |  ...||  ..| . |... ..|.|. .      .|| ..| | |. . .. . |  .|| . .....|.
dltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicks

VDNT------KGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCR-PGSVIGPQQPYLIEKQ
...       .. |.|||||||||.||..|...|. ..||| | . ..| .| ||..  |.|  |.| .
fiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyf
0048179 (Phosphotyrosine protein) phosphatases II 230-343 1.6e-26 88.1 In-house 22-138 (144) alignment 
Range on Protein: 230-343
Range on HMM: 22-138/144.0
FDYFRENKVSTIVRLNAKnYDASKFTKAGFDHVDLFFIDGSTPSD-EIMLKFIKVVDNT---KGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWL
..........|...|. . |.   ... |. .. | . | ..|.. |..|.|.. ...    .| |.|||.||.||||||.|...||..||.. |.. ..
lellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalv

RVCRPGSVIGPQQPYLIE
| .|||.|. |.| . ..
rsrrpgavpnpgqlrfLl
0047943 (Phosphotyrosine protein) phosphatases II 178-342 3.7e-26 87.6 In-house 22-264 (273) alignment 
Range on Protein: 178-342
Range on HMM: 22-264/273.0
FSDFDYEEYEFYERVENGDFNWI------------------------------IPGKILSFCGPHnesreengypYHAPDVYFDYFRENKVSTIVRLNAK
.| ... .|......||.|.|..                              .. |.. . ||           ..  . ..... |..|..||.|.  
lslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl..........pntvedfwrmvweqnvrviVmLtel

NYDAS---------------------------KFTKAGFDHVDLF-------------------FIDGSTP-SDEIMLKFIKVVDN------TKGGVAVH
 ..                              .||... .  |                    . | ..| | |..|.||..|..       .| |.||
velgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVH

CKAGLGRTGTLIACWMM-----KEYGLTAGECMGWLRVCRPGSVIGPQQPYLI
|.||.|||||.||....     ||.|... |.. .|| .|||.|. |.| ...
CsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0048076 (Phosphotyrosine protein) phosphatases II 230-342 1.6e-25 84.8 In-house 22-135 (145) alignment 
Range on Protein: 230-342
Range on HMM: 22-135/145.0
FDYFRENKVSTIVRLnakNYDASKFTKAGFDHVDLFFIDGSTPSD-EIMLKFIKVVDNT---KGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWL
......... |...|    .. . ... |. .. | . | ..|.. |..|.|.. ...    .| |.|||.||.||||||.|...|...|... |.. ..
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

RVCRPGSVIGPQQPYLI
| .|||.|. |.| . .
rsqrpgavpnpgqlrfl
0051299 (Phosphotyrosine protein) phosphatases II 223-342 2.3e-20 68.7 In-house 61-278 (288) alignment 
Range on Protein: 223-342
Range on HMM: 61-278/288.0
YHAPDVY-----------------------------------------FDYFRENKVSTIVRLNAKN---------------------------------
|    |.                                         . .  |..|..||.|.                                    
ydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevld

----------------YDASKFTKAGFDHVDLFfiDGSTPS-DEIMLKFIKVVDNT----KGGVAVHCKAGLGRTGTLIACWMM-----KEYGLTAGECM
                .|  ..|   | . .    | ..|.  | .|.|.. |..     .| |.|||.||.|||||.||....     ||.|... | .
dytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

GWLRVCRPGSVIGPQQPYLI
 .|| .|||.|. |.| ...
krlreqRpgmvqtpeqyrfv
0046845 (Phosphotyrosine protein) phosphatases II 230-342 2.4e-20 68.5 In-house 94-266 (284) alignment 
Range on Protein: 230-342
Range on HMM: 94-266/284.0
FDYFRENKVSTIVRLNAKN-----------------------------------Y------------DASKFTKAGFDHVDLFfiDGSTP-SDEIMLKFI
.    |..|..|| |.                                      |            .   .|   | . .    | ..| | |..|.|.
wrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswp..dhgvppspedllefl

KVVDNT------KGGVAVHCKAGLGRTGTLIACWMMKEY--------GLTAGECMGWLRVCRPGSVIGPQQPYLI
. |..       .| ..|||.||.|||||.||.....|.        |... |.. .|| .|||.|  ..| ...
rlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
0051429 (Phosphotyrosine protein) phosphatases II 221-343 8.1e-20 67.0 In-house 29-218 (272) alignment 
Range on Protein: 221-343
Range on HMM: 29-218/272.0
YPYHAPDVYFDYFRENKVSTIVRLNAKNYDA---SKFTKAGFDHVDLFFIDGSTPSD-------------------------------------------
.| .. .  |....|....||| |   .. .     .  .|.... | ..| |.|.                                            
gplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhyt

---------EIMLKFIKVVDNtKGGVAVHCKAGLGRTGTLIACWMMKeYGLT--------------AGECMGWLRVCRPGSVIGPQQPYLIE
         | .|...... . .| | |||.|| .||||..|....  .|..              . |.. .|| .|||.|  ..| . . 
dwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly
0036941 (Phosphotyrosine protein) phosphatases II 231-342 2.2e-19 65.3 In-house 72-269 (297) alignment 
Range on Protein: 231-342
Range on HMM: 72-269/297.0
DYFR------------------------ENKVSTIVRLNAKNYD---------------------------------ASKFTKAGFDHVD----------
| ..                        |..|..|| |.    .                                  . .|   .  .|          
dgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvt

----LFFIDGSTPS-DEIMLKFIKVVDN------TKGGVAVHCKAGLGRTGTLIACWMM--------KEYGLTAGECMGWLRVCRPGSVIGPQQPYLI
    .   | ..|.  ...|.||. |..       .| | |||.||.||.||.||...|        ||.|..  |.. .|| .|||.|  ..| . .
hfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl
subfamily_PRL_pd Subfamily PRL 228-342 5.2e-18 59.5 In-house 25-143 (151) alignment 
Range on Protein: 228-342
Range on HMM: 25-143/151.0
VYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVD-----NTKGGVAVHCKAGLGRTGTLIACWMMkEYGLTAGECM
 . . .....|.|.||    .||..|. |.| . .|| | ||..|..|.. ......      ..|  ||||| |||||.  |.|  .. | |..  . .
kfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali.eaGmkyedav

GWLRVCRPGSVIGPQQPYLI
 ..|  | |..   |  .| 
efirekrrgainskqlkfle
subfamily_PTPDC1_pd Subfamily PTPDC1 248-338 5.8e-17 56.7 In-house 72-164 (182) alignment 
Range on Protein: 248-338
Range on HMM: 72-164/182.0
NYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVDN--TKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVIGPQQ
 ||  .....|  .  . . | ...| | .|  .|||.   ..| ||||| ||||||| ||||...    ||| . .  .|  || |.   .|
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreq
subfamily_DSP23_pd Subfamily DSP23 230-344 1.6e-16 55.3 In-house 24-140 (148) alignment 
Range on Protein: 230-344
Range on HMM: 24-140/148.0
FDYFRENKVSTIVRLNAKNYDASKFTkAGFDHVDLFFIDGSTPSDEIMLKFIKVVDNTK---GGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLR
. |. .. |  .| |  .    .. |  .   | |   |   |. | . .|..||....     |.|||  | |||||..||...|| .|.|.| .  .|
yrylldlgvrylvslteegrphveat.pnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevr

VCRPGSVIGPQQPYLIEK
  |||||   .|  |. .
rlrpgsvetveqeklvrd
DSPc Dual specificity phosphatase, catalytic domain 276-334 8.6e-14 46.5 Pfam-A 61-117 (133) alignment 
Range on Protein: 276-334
Range on HMM: 61-117/133.0
IMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRpgSVI
 . .||. ... .. |.|||.||. |..|||....||...|.. |..  ..  |  | |
eavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..ski
DSPc Dual specificity phosphatase, catalytic domain 276-334 8.6e-14 46.5 In-house 61-117 (133) alignment 
Range on Protein: 276-334
Range on HMM: 61-117/133.0
IMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRpgSVI
 . .||. ... .. |.|||.||. |..|||....||...|.. |..  ..  |  | |
eavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..ski
PTPc_motif_SM00404 275-337 1.3e-13 46.0 In-house 67-127 (140) alignment 
Range on Protein: 275-337
Range on HMM: 67-127/140.0
EIMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRpgSVIGPQ
. .|.||. . ...| | |||.||. |..|||....|....|.. |..  ... |  . | |.
dkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..piispn
THAP THAP domain 954-1027 1.6e-13 37.2 Pfam-A 3-82 (85) alignment 
Range on Protein: 954-1027
Range on HMM: 3-82/85.0
CCY--C---LEVYEKRYMTQVPKTEQRIARWVAILGEQFRirLRMKPANYMCRKHFPQADF---SSRGRLLKTAVPNVVSQE
|..  |    .  .|  . ..||.|.....|.. ||.. .   . .  ...| .|| . ||   ... || |.||| . ..|
CavasCsnskkkkkkvsfhkfPkdeellkkWlkalgrede..eeplknsriCseHFeeedfkkekkkrrlkkgavPtlfege
subfamily_PTPMT1_pd Subfamily PTPMT1 251-334 1.6e-12 42.2 In-house 66-153 (171) alignment 
Range on Protein: 251-334
Range on HMM: 66-153/171.0
ASKFTKAGFDHVDLFFIDGS-TPSDEIML---KFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVI
  ...| | ... |  .|   .|. | ..   .||. | ...  | |||||| ||..||.||..||.. |.  | .  |. .|.   .
teewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirl
subfamily_RNGTT_pd Subfamily RNGTT 228-332 3.1e-10 34.0 In-house 43-157 (189) alignment 
Range on Protein: 228-332
Range on HMM: 43-157/189.0
VYFDYFR--ENKVSTIVRLN--AKNYDASKFTKAGFDHVDLFFI-DGSTPSDEIMLKFIKVVDN-----TKGGVAVHCKAGLGRTGTLIACWMMKEYGLT
. ..|..  ..|.  .. |    . ||.....| |  .| |     | .|. | . .|||.|..     ..  ..|||. |  ||| ||.......    
mllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws

AGECMGWLRVCRPGS
. . .   . .||  
veaavalFakaRppG
subfamily_PTEN_pd Subfamily PTEN 241-318 6.1e-10 34.4 In-house 64-144 (184) alignment 
Range on Protein: 241-318
Range on HMM: 64-144/184.0
IVRL-NAKNYDASKFTKAgFDHVdlFFIDGSTPSDEIMLKFIKVVDN-----TKGGVAVHCKAGLGRTGTLIACWMMKEYGLTA
|  |   ..||..||..    ..   | |  .|. |.. .... ...     .|  |.|||||| ||||.||.....|.  |. 
iynlrserkydskkfdgr.vavy..pfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllek
subfamily_DSP19_pd Subfamily DSP19 277-331 3.4e-09 31.2 In-house 78-132 (152) alignment 
Range on Protein: 277-331
Range on HMM: 78-132/152.0
MLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPG
.|.||. . ...| | |||.||  |. ...  ..||.  |.  |..  .|  || 
aldFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc
subfamily_DSP1_pd Subfamily DSP1 277-336 3.9e-08 27.5 In-house 84-141 (163) alignment 
Range on Protein: 277-336
Range on HMM: 84-141/163.0
MLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPgsVIGP
...||. | ...| | .||.||. |  ||.  ..||.  ..  | . . .  |.  .| |
viefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs..iisP
PTPc_DSPc_SM00012 272-313 4.8e-08 28.5 In-house 16-64 (105) alignment 
Range on Protein: 272-313
Range on HMM: 16-64/105.0
PS-DEIMLKFIKVVDNTKG------GVAVHCKAGLGRTGTLIACWMMKE
|.  . .|.... |.. |        | |||.|| |||||..|  .. .
PeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillq
subfamily_DSP11_pd Subfamily DSP11 247-329 1.1e-07 25.9 In-house 68-157 (178) alignment 
Range on Protein: 247-329
Range on HMM: 68-157/178.0
KNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVVDNTK-------GGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCR
. |. ...|. |  .. |.    ..|..|.. ||...|.. .         ..|||  |. ||| ||  ....  |. . . .  .  .|
ryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear
subfamily_DSP12_pd Subfamily DSP12 277-328 1.1e-07 26.3 In-house 71-122 (155) alignment 
Range on Protein: 277-328
Range on HMM: 71-122/155.0
MLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVC
...||.   ...| | |||.||. |  |... ..||...|   . .  ..  
avdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkek
subfamily_DSP10_pd Subfamily DSP10 278-346 1.2e-07 25.7 In-house 82-148 (159) alignment 
Range on Protein: 278-346
Range on HMM: 82-148/159.0
LKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPgsVIGPQQPYLIEKQK
|.||. . ..   | |||.||. |  |..  ..||. .|.  .   . ...||  .| |   .. .  .
lefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPnLnfmGqLle
Y_phosphatase Protein-tyrosine phosphatase 273-314 1.3e-07 26.6 Pfam-A 151-196 (235) alignment 
Range on Protein: 273-314
Range on HMM: 151-196/235.0
SDEIMLKFIKVVDNTK----GGVAVHCKAGLGRTGTLIACWMMKEY
| . .|..|. | ..|    | | |||.|| |||||..| ... | 
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
Y_phosphatase Protein-tyrosine phosphatase 273-314 1.3e-07 26.6 In-house 151-196 (235) alignment 
Range on Protein: 273-314
Range on HMM: 151-196/235.0
SDEIMLKFIKVVDNTK----GGVAVHCKAGLGRTGTLIACWMMKEY
| . .|..|. | ..|    | | |||.|| |||||..| ... | 
spkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq
subfamily_Slingshot_pd Subfamily Slingshot 278-342 4.9e-07 23.3 In-house 86-148 (169) alignment 
Range on Protein: 278-342
Range on HMM: 86-148/169.0
LKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRpgSVIGPQQPYLI
 |||. . ...  | |||| |. |. . .  . ||||||.  |.. ...  |  ||| | . .| 
ykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgflk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 273-329 6.8e-07 23.2 In-house 201-256 (290) alignment 
Range on Protein: 273-329
Range on HMM: 201-256/290.0
SDEIMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYgLTAGECMGWLRVCR
|.  .|. .... .. | |.||| ||.|||||..|  .  .  |. |  .  | ..|
stlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqi.lldGkeldlldlvr
subfamily_LRR-DSP_pd Subfamily LRR-DSP 286-351 8.9e-07 22.3 In-house 195-258 (263) alignment 
Range on Protein: 286-351
Range on HMM: 195-258/263.0
NTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPgsVIGPQQPYLIEKQKFCWSL
  |||| |||.||. |. ||. ...||   |.  | .      ||   | | . ..   .|.   |
rkkGGvlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrp..riqPnpGfkdqlkkyekkl
DSPc_SM00195 270-311 1.1e-06 23.6 In-house 172-218 (263) alignment 
Range on Protein: 270-311
Range on HMM: 172-218/263.0
STP-SDEIMLKFIKVVDNT----KGGVAVHCKAGLGRTGTLIACWMM
..| | . .|.....|...    .| . |||.||.|||||...  ..
gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
PTPc_SM00194 270-311 1.1e-06 23.6 In-house 172-218 (263) alignment 
Range on Protein: 270-311
Range on HMM: 172-218/263.0
STP-SDEIMLKFIKVVDNT----KGGVAVHCKAGLGRTGTLIACWMM
..| | . .|.....|...    .| . |||.||.|||||...  ..
gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidii
subfamily_DSP3_pd Subfamily DSP3 242-329 1.2e-06 22.3 In-house 51-138 (162) alignment 
Range on Protein: 242-329
Range on HMM: 51-138/162.0
VRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMlKFIK-VVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCR
|  .|. |. ....  |..  | . .| |.  .. . |||.  .....| | |||..|. |  ||.  ..|    .|. | .   |  |
vdtgaefykdleikylGlevdDvpefdlskyFetaa.kfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkR
subfamily_VSP_pd Subfamily VSP 246-326 1.4e-06 22.4 In-house 84-167 (212) alignment 
Range on Protein: 246-326
Range on HMM: 84-167/212.0
AKNYDASKFTKagfdHVDL-FFIDGSTPSDEIMLKFIKVVD-----NTKGGVAVHCKAGLGRTGTLIACWMMK-EYGLTAGECMGWLR
 ..|| . | .    .|      |   |. | .|.| | |      ..|  .|.||| | |||||.. ..... |   || |.. .. 
eraydekyfnn....rvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 268-308 1.4e-06 22.0 In-house 200-241 (302) alignment 
Range on Protein: 268-308
Range on HMM: 200-241/302.0
D-GSTPSDEIMLKFIKVVDNTKGGVAVHCKAGLGRTGTLIAC
| |.    .  |. .|  .  |  | ||| ||.||||||.| 
dhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvai
subfamily_DSP14_pd Subfamily DSP14 277-360 3.9e-06 20.9 In-house 72-153 (157) alignment 
Range on Protein: 277-360
Range on HMM: 72-153/157.0
MLKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPgsVIGPQQPYLIEKQKFCWSLSQSNGVHLT
. . |. |....| . |||.||  |  .|   ..||   |.  |   ... .||  .| | . .  . ...   | ... |.. 
vadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iirPNvGFwkqlidyEkklkgkssvkmv
subfamily_DSP15_pd Subfamily DSP15 278-350 4.9e-06 20.7 In-house 68-138 (151) alignment 
Range on Protein: 278-350
Range on HMM: 68-138/151.0
LKFIKVVDNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRpgSVIGPQQPYLIEKQKFCWS
 .||      ...| ||| ||. |  ||.. ..|    |   ...  .. .|  ||  |   .    ... ..
vefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaR..svanPnfGfkrqlkeyekt
subfamily_PTPN13_pd Subfamily PTPN13 270-309 5.4e-06 20.9 In-house 180-223 (273) alignment 
Range on Protein: 270-309
Range on HMM: 180-223/273.0
STPSDE-IMLKFI---KVVDNTKGGVAVHCKAGLGRTGTLIACW
..||    .|.|.   . ... .| ..||| ||.||.||||.  
gvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitid