Gene cel-1 in Caenorhabditis elegans

Synonym: CELE_C03D6.3, cel-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP045_AA protein Get Run
CeleP045_AA_23-194 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 16-205 2.2e-87 285.6 In-house 1-188 (189) alignment 
Range on Protein: 16-205
Range on HMM: 1-188/189.0
PDRWLHCPKTGTLINNLFFPFKTPLCKMYDNQIAERRyQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDN
|.|||.||..|.||.. |.||||||.|.||...||.. .|.|....|. .....|.||.||||||.||| .||...... |.|...||.|..|..|....
PerWlnCPrkgkliaekflpfktplskrydddlaeen.rfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFARYDPTeDDKILAPEKPDWER
|||||.||.||.|..|.|||||||||||||||..||...|.....||. .||..|..||||.||...|..||. . ...| |||.|||..
fiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv.eeaiaapelpdwcl
mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 289-479 5.7e-70 224.2 Pfam-A 1-192 (192) alignment 
Range on Protein: 289-479
Range on HMM: 1-192/192.0
QPVSLSRGNINLLEQESYMVSWKADGMRYIIYINDGDVYAFDRDNEVFEIENLDFVTKN-GAP---LMETLVDTEVIIDKVEIngamCDQPRMLIYDIMR
||||||| |..||.|..|.||.||||.|....|.. .||..||||||...|||.|..|. ...   ...||.|.|..||.||     ....|.|||||..
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkkevylidrdnevylvenlkfplklekekekvhhgtllDGElvidtvee....eqklryliyDila

FNSVNVMKEPFYKRFEIIKTEIIDMRTAA-FKTGRLKHENQIMSVRRKDFYDLEATAKLFGPKFVQHVGHEIDGLIFQPKKTKYETGRCDKVLKWK
.|...|...|..||.||.|.|||..|... .||...|.|.. ..||.|.|..|.|..||.  |..... |||||||||...|.| .||....||||
ingelvserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK
0038934 (Phosphotyrosine protein) phosphatases II 15-205 2e-53 176.2 In-house 2-190 (194) alignment 
Range on Protein: 15-205
Range on HMM: 2-190/194.0
LPDRWLHCPKTGTLINNLFFPFKTPLCKMYDNQIAeRRYQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTD
||||||.....|..|.. | .||.||....|..|    |.|.|  ...  .|...|.||.||||||.||| .||.... . |.|. . ..|..|..| ..
lPdrwlkyervgdiitgrfiafkvPlsgsldkyie.elyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

NFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFARYDPTEDDKIlAPEKPDWER
.|..||.||... |. ||.|||..|..|||.|.||||...  . ...||. |.| |...|..|||...|. ||...... . |||||..  
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavl.apekpelll
subfamily_DSP11_pd Subfamily DSP11 15-185 1.8e-42 139.2 In-house 1-172 (178) alignment 
Range on Protein: 15-185
Range on HMM: 1-172/178.0
LPDRWLHCPKTGTLINN-LFFPFKTPLCKMYDNQIAERRyQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVsPTQEDT
.|||| .  . |. |.   | .||||| . .|....| . .| | ..... . ..||.|| |||||||||| ..|.|...  |.|....|. | |..|  
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeek.rftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelv

DNFIKLVQEFH--KKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFA
..|.. |.||   .|  |...||||||| ||||.||  || .||.|  . ||  | | |   . ...|..||  
kkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk
mRNA_cap_C mRNA capping enzyme, C-terminal domain 482-585 2e-34 107.5 Pfam-A 1-105 (105) alignment 
Range on Protein: 482-585
Range on HMM: 1-105/105.0
SHNSVDFLLKVEKKCKEGMLPEWIGYL-FVQNLSDPF----GTMKATATLKKYHNKIIECTLlvDNqgRPKEWKFMRERTDKSLPNGLRTAENVVETMVN
..|.||||||.||....|.|.|. |.| .|.. ||.|     ..|.....|....||.||.|  |.  . ..|||.|.|.||| ||...|||.|.... .
elntvDfllklekeeedglLeeekgkldyveggsdefitakekeklksdekelkgkIvEckl..dd..kkgrWkflriRkDKsepNsistaekvlksied

PVTETYLIE
.||...|.|
nvtkeeLle
0036282 (Phosphotyrosine protein) phosphatases II 25-183 2.2e-24 81.5 In-house 11-162 (174) alignment 
Range on Protein: 25-183
Range on HMM: 11-162/174.0
TGTLINNLFFPFKTPLCkmydnqIAERRYQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYfreeVTEHECIYHKMKMAGRGVSPTQEdTDNFIKLVQEFH
 .. |.. .. .. ||.        |  ....   |..  ... ......|......|..     ... . |... . ..|| ....  ..|.|.|.|..
dlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsi.llefvkfveeal

KKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEY-GLDAAIGEFAENR---QKGIYKQDYIDDL
.. |...| |||..|..|||.|.||||  .  . .|. |.  ..| |    .... ....  |
sedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl
0044763 (Phosphotyrosine protein) phosphatases II 56-184 4.6e-21 70.7 In-house 22-164 (178) alignment 
Range on Protein: 56-184
Range on HMM: 22-164/178.0
HPAEVF------------SHPHLHGKKIGLWIDLTNTDRYY----FREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHG
.. |..              . |.  .|.....||......    ... ..|... |... . . || .  | ...|.....|...  ....| |||..|
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaG

FNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQkGIYKQDYIDDLF
..|.| |.||||  .  . |..|| .. | |  ... ....  | 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLy
PTEN_1 10-175 1e-20 69.4 In-house 10-176 (196) alignment 
Range on Protein: 10-175
Range on HMM: 10-176/196.0
KARMGLPDRWLHCPKTGTLINNLFFPFKTPLCKmydnQIAERRYQFHPAEVFSHP-HLHGKKIGLWIDLTNTDRY----YFREEVTEHECIYHKMKMAGR
| .. ||...| ..   . |   .... .||..    .| |..|. .  .| ..  .|....| |...|.. . .    |  ||  .. ..|... .   
kknlalptelldltyitsriiamgkapsrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDh

GVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIY
|... .|  |   .. .   .. . .|| |||..| .|.|...|||| . . .  | |.  ..| | .|  
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgap
0041856 (Phosphotyrosine protein) phosphatases II 63-176 1.1e-19 66.2 In-house 51-156 (182) alignment 
Range on Protein: 63-176
Range on HMM: 51-156/182.0
HPHLHGKKIGLWIDLTntDRYYFREEVTEHECIYHKMKMAGRGVSPtQEDTDNFIKLVQEfhkkyPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAA
 . |.. .|.. ..||  ...|. |... . . |... . . || .  ... .||. |.|     ....| |||..| .|||.|.||||  . ...|. |
lrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleea

IGEFAENRQKGIYK
. .. . | ...  
vklvrsrRpgmvit
0043147 (Phosphotyrosine protein) phosphatases II 66-181 1.2e-19 66.1 In-house 40-151 (172) alignment 
Range on Protein: 66-181
Range on HMM: 40-151/172.0
LHGKKIGLWIDLTntDRYYFREEVTEHECIYHKMKMAGRGVSpTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQvEEYGLDAAIGE
|. ..|.....||  ...| .| .... . |. . .   ||  . |  ..|.....|.. ..|. .| |||..|..|||.|.|||| . . . |. |. .
lkelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeaval

FAENRQKGIYKQDYID
. | | .... .... 
vrekRpgavqnpsqyr
0040439 (Phosphotyrosine protein) phosphatases II 42-180 2.6e-19 65.3 In-house 6-235 (249) alignment 
Range on Protein: 42-180
Range on HMM: 6-235/249.0
KMYDNQIAERRYQFHPAEVFSHPHLHG--------------------------------------------KKIGLWIDLTNTDRY--------------
 .. . .  .||. ...  .| ..|.                                              .|.  ..||.....              
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

-----------------------------YFREEVTEHECIYHKMKmaGRGVSPTQEDTDNFIKLVQEFHKKY-PDRVVGVHCTHGFNRTGFLIAAYLF-
                             |. |..| .   |...     ||.|. ||...||..|....... .. .| |||..| .|||..|||||  
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

----QVEEYGLDAAIGEFAENRQKGIYKQDYI
       .. |. |. .. . | .... ....
eqlekelgvdleeavkllrsqRpgavqnpeqy
0048076 (Phosphotyrosine protein) phosphatases II 61-184 2.8e-19 64.7 In-house 20-136 (145) alignment 
Range on Protein: 61-184
Range on HMM: 20-136/145.0
FSHPHLHGKKIGLWIDLTNTDRYYFreevtEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLD
 . ..|.  .|.....||.. ....     .. . |. . . ..|| .  |. ..|.....|..|.  ...| |||..| .|||.|.||||   . . |.
ldlellkdlgittvlnltselelle.....rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmlllgvsle

AAIGEFAENRQKGIYKQDYIDDLF
 |. .. . | .... ....  |.
ealelvrsqrpgavpnpgqlrfly
0048179 (Phosphotyrosine protein) phosphatases II 60-183 2.4e-18 61.7 In-house 19-137 (144) alignment 
Range on Protein: 60-183
Range on HMM: 19-137/144.0
VFSHPHLHGKKIGLWIDLTNTdryYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkyPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGL
. . ..|.  .|...|.||..   |  |... . . |... . ..|| .  |. ..|.....|...  ....| |||..|..|||.|.||||  .. . |
aldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsl

DAAIGEFAENRQKGIYKQDYIDDL
. |. .. . |  ... ....  |
eealalvrsrrpgavpnpgqlrfL
0049260 (Phosphotyrosine protein) phosphatases II 69-184 1.2e-17 59.4 In-house 30-143 (152) alignment 
Range on Protein: 69-184
Range on HMM: 30-143/152.0
KKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFhKKYPDRVVGVHCTHGFNRTGFLIAAYLFQvEEYGLDAAIGEFAE
|. | .. .. |..... .. .|.   |. . .   || .  .  . ........ ..... .| |||..|..|||.|.||||     . |. |.  . |
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvre

NRQKGIYKQDYIDDLF
 | .... ....  |.
kRpgavpnpgqlrfly
0049772 (Phosphotyrosine protein) phosphatases II 37-171 3.8e-17 58.4 In-house 145-255 (314) alignment 
Range on Protein: 37-171
Range on HMM: 145-255/314.0
KTPLCKMYDNQiaerryqfhpaevfshPHLHGKKIGLWIdltntDRYYFREEVTEHECIYHKMKMAGrGVSPTQEDTDNFIKLVQEFhkkYPDRVVGVHC
||||...  |.                .... . . |.      ...| .| ....   |. . . . |  |. || | |.....|.    ....| |||
Ktpllildgng................neptaadlellk.....eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHC

THGFNRTG-FLIAAYLFQVEEYGLDAAIGEFAENRQ
..| .||| |..||||     . |. |. .. . | 
kaGkgRtgtfvvaaylmkllgvsleealedvrlkRp
0037934 (Phosphotyrosine protein) phosphatases II 65-180 9.3e-17 56.8 In-house 67-231 (243) alignment 
Range on Protein: 65-180
Range on HMM: 67-231/243.0
HLHGKKIGLWIDLTNTD----------------------------------------RYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFH
 |.  .|.  ..||...                                        ...  ...| . . || . . . || .. ||  .|.. |.|| 
mlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefi

KK-------YPDRVVGVHCTHGFNRTGFLIAAYLFQVE-EYGLDAAIGEFAENRQK-GIYKQDYI
..        ....| |||..| .||| ||||||     ...|. |. .. | |   ..  ....
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy
0045450 (Phosphotyrosine protein) phosphatases II 66-180 1.2e-16 56.8 In-house 127-293 (307) alignment 
Range on Protein: 66-180
Range on HMM: 127-293/307.0
LHGKKIGLWIDLTNTDRY-----------------------YFREEVTEHECIYHKMKM--------------------AGRGVSPTQEDTDNFIKLVQE
|. ..... ..||... .                       ....| ............                     . ||.|. |.. .||..|..
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

FHKKY-PDRVVGVHCTHGFNRTGFLIAAYLFQVEE--------YGLDAAIGEFAENRQKGIYKQDYI
..... .. .| |||..| .||| .|||||  .          . |. |. .. | | ...  ....
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy
0039614 (Phosphotyrosine protein) phosphatases II 67-175 2.5e-15 52.2 In-house 122-273 (297) alignment 
Range on Protein: 67-175
Range on HMM: 122-273/297.0
HGKKIGLWIDLTNTDRY--------------------YFREEVTEHECI-----------------YHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKY-P
.  ..   . ||... .                    ..... ... ..                 .. ...   || |. |. ..|..||.|..... .
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

DRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIY
...| |||..| .||| .|||||         .. .. |. |. | | ... 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavq
0042113 (Phosphotyrosine protein) phosphatases II 75-179 3.7e-15 51.5 In-house 81-231 (245) alignment 
Range on Protein: 75-179
Range on HMM: 81-231/245.0
IDLTNTDRYYF-----------------------------------------REEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKYPDRVVG
..||... . .                                         ..  . . . || . . . || .. |. ..|...|... .. .. .| 
vmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvl

VHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIYKQDY
|||..| .||| .|||||         .. |. |. |. . | . .  ...
VHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsq
0040438 (Phosphotyrosine protein) phosphatases II 67-179 4.7e-15 51.1 In-house 107-264 (317) alignment 
Range on Protein: 67-179
Range on HMM: 107-264/317.0
HGKKIGLWIDLTNTDRY----------------------YFREEVTEHECIYHKMKM-------------------AGRGVSPTQEDTDNFIKLVQEFHK
.  .... . ||... .                       ...|.............                      || |. ..  .|...|.|. .
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

kYPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIYKQDY
  |. .| |||..| .|||..|||||      . ... .. |. |. | | ....  ..
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq
0051082 (Phosphotyrosine protein) phosphatases II 64-172 4.5e-14 47.8 In-house 27-134 (151) alignment 
Range on Protein: 64-172
Range on HMM: 27-134/151.0
PHLHGKKIGLWIDLTNTD-RYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHGFNRTGFLIAAYLFQvEEYGLDAA
. |.  .|   ..|.... |.|. | ..|..  .. . . .  . .... .| ........ .  .. .| |||..| .|||.|.|.||   . . |..|
ellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

IGEFAENRQK
. |. . |  
leeyrlkrpg
0046846 (Phosphotyrosine protein) phosphatases II 71-174 6.1e-13 44.4 In-house 48-156 (176) alignment 
Range on Protein: 71-174
Range on HMM: 48-156/176.0
IGLWIDLTNTD------RYYFREEVTEHECIYHKMKMAGRGVSPTqEDTDNFIKLVQEFHKKYpdRVVGVHCTHGFNRTGFLIAAYLFQV-EEYGLDAAI
|.. ..||.         ... .|...... |. . .   || .  |. ........|. |.   ..| ||| .| .||| |.|||| .    . .. |.
itavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveeal

GEFAENRQ-KGI
 .. | |  . .
alvreqRplgav
0043336 (Phosphotyrosine protein) phosphatases II 86-175 1e-12 43.6 In-house 168-261 (278) alignment 
Range on Protein: 86-175
Range on HMM: 168-261/278.0
REEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIY
..  . . ..|| ...   || .. ..  .|.| |.|. .  .. .| |||..| .||| .||.||         .. |. |. |. | | . . 
gdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavq
DSPc Dual specificity phosphatase, catalytic domain 65-179 2.2e-11 38.7 Pfam-A 13-123 (133) alignment 
Range on Protein: 65-179
Range on HMM: 13-123/133.0
HLHGKKIGLWIDLTNTDRY-YFREEVTEHECIYH--KmkmagRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDA
 |  ..| | |..|.. .  .....   ..  .            . .... .. .. ......|   . | |||..| .|.. ||.||| . ... |. 
lleklgitlvinvtkevpnnnaikkseieylripved.....etetkiskeleeavefiekaeqk..gkkvlVHCqaGisRSatliiaYlmktknlslne

AIGEFAENRqKGIYKQ-DY
|.  . |.| . | ..  .
Ayefvkerr.skispnagf
DSPc Dual specificity phosphatase, catalytic domain 65-179 2.2e-11 38.7 In-house 13-123 (133) alignment 
Range on Protein: 65-179
Range on HMM: 13-123/133.0
HLHGKKIGLWIDLTNTDRY-YFREEVTEHECIYH--KmkmagRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDA
 |  ..| | |..|.. .  .....   ..  .            . .... .. .. ......|   . | |||..| .|.. ||.||| . ... |. 
lleklgitlvinvtkevpnnnaikkseieylripved.....etetkiskeleeavefiekaeqk..gkkvlVHCqaGisRSatliiaYlmktknlslne

AIGEFAENRqKGIYKQ-DY
|.  . |.| . | ..  .
Ayefvkerr.skispnagf
0046845 (Phosphotyrosine protein) phosphatases II 76-175 3.6e-11 38.5 In-house 141-258 (284) alignment 
Range on Protein: 76-175
Range on HMM: 141-258/284.0
DLTNTDRYYFR---------EEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKK-YPDRVVGVHCTHGFNRTGFLIAAYLFQVE--------EY
. .. | |  |         .. . .  ..| ..   .|| |. ||  .|..||.|.... ... .. ||| .| .||| .||..|            ..
seevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgv

GLDAAIGEFAENRQKGIY
 .  |.  . | |   . 
dvleavkrlreqRpgmvq
0045098 (Phosphotyrosine protein) phosphatases II 75-172 4.3e-11 38.2 In-house 137-252 (278) alignment 
Range on Protein: 75-172
Range on HMM: 137-252/278.0
IDLTNTDRYYFREEVTEHECIYHKM-KMAGRGVSPTQ--EDTDNFIKLVQEFHK------------KYPDRVVGVHCTHGFNRTGFLIAAYLFQVE---E
..|. |. .. ||. ....  ....  .   || ..      ..... ..|..|              .. .| ||| .| .||| |.||||        
rtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlellegg

YGLDAAIGEFAENRQK
. |. |. |. . |  
vdlleavkelrsqRpg
DNA_ligase_A_M ATP dependent DNA ligase domain 303-479 1.2e-10 30.2 Pfam-A 18-202 (202) alignment 
Range on Protein: 303-479
Range on HMM: 18-202/202.0
QESYMVSWKADGMRYIIYINDGDVYAFDRDNEVFEI---ENLDFVTKNGAPL-METLVDTEVII-D--------KVEINGA----------MCDQPRMLI
.. ..|..| || | ..  ....|... |  . .     | |... .  ..   . ..| |... |          ..             .  ......
egafiveeKyDGeRvqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsffv

YDIMRFNSVNVMKEPFYKRFEIIKTEIidmrtaafktgrLKHENQIMSVRRKDFYDLEATAKLFgpkfVQHVGHEIDGLIFQPKKTKYETGR-CDKVLKW
.|.. .. .....||. .|...... .             . ||.|  .. .. .|.|  ..|.     . . .. .|...  .. ||| |. . . || 
FDvlyldgesltdepleeRrklLeeif............kesenrieiaetlevndveeleell....eevikeglEGvvlKdpdskYepgkrssnwlKl

K
|
K
0051429 (Phosphotyrosine protein) phosphatases II 62-178 2.3e-10 36.1 In-house 37-212 (272) alignment 
Range on Protein: 62-178
Range on HMM: 37-212/272.0
SHPHLHGKKIGLWIDLTNTDRYYFRE-EVTEHECIYHKMKMAGRGVSPTQ--------------------------------------------------
. ..|.  .|   .||.... . .   .   . . |. . . .... .                                                    
dfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvp

-EDTDNFIKLVQEfhkkypDRVVGVHCTHGFNRTGFLIAAYLFQvEEYG--------------LDAAIGEFAENRQKGIYKQD
 |   ....|...      .. | |||..| .|||...|..|   .  .              |..|. |  . | . .  ..
qeallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee
0047943 (Phosphotyrosine protein) phosphatases II 92-175 2.6e-10 35.7 In-house 167-256 (273) alignment 
Range on Protein: 92-175
Range on HMM: 167-256/273.0
HECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKY-PDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIY
. ...| ..    || |. |.  .||.||.......  . .| ||| .| .||| .||..|         .  .. |.  . . |  ...
tvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq
PTPc_motif_SM00404 66-180 4.2e-10 34.7 In-house 23-131 (140) alignment 
Range on Protein: 66-180
Range on HMM: 23-131/140.0
LHGKKIGLWIDLTNTDRYYfreevtE--HECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAI
|  ..| . |..|.. .        .   .  . ....   ........ |. .. .....||   . | |||..| .|.. ||.||| . ... |..|.
lkklgithvinvteevslt......kensgfqilqiplddnekdklskyldkvldfienaekk..ggkvlVHCqaGvSRSatliiaYlmryrqlslaeay

GEFAENRqKGIYKQ-DYI
  . |.| . | ..  ..
efvkerR.piispnlnfv
subfamily_PTPDC1_pd Subfamily PTPDC1 84-181 5.3e-10 34.0 In-house 73-166 (182) alignment 
Range on Protein: 84-181
Range on HMM: 73-166/182.0
YFREEVTEHECIYHKMKMAGRGVSPTQEdTDNFIKLVQEFHKKYpdrVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYID
|  |...|.. ..... ..  || . ..   . .|.|.   ..     |.|||  |  ||| |||.||  ....  . ||    ..| | |. .. ..
YdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqve
subfamily_DSP23_pd Subfamily DSP23 106-173 7.1e-10 33.7 In-house 63-128 (148) alignment 
Range on Protein: 106-173
Range on HMM: 63-128/148.0
VSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKG
  |. |. ..|...|.| ..|  .  |.|||  |. ||| ..| || . ..     || |  . |   
hppaleqvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgs
0036941 (Phosphotyrosine protein) phosphatases II 94-171 1.2e-09 33.4 In-house 171-257 (297) alignment 
Range on Protein: 94-171
Range on HMM: 171-257/297.0
CIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKY-PDRVVGVHCTHGFNRTGFLIAAYLF--------QVEEYGLDAAIGEFAENRQ
 ..| ..    || .. ..  .||.||....|.. .. .| ||| .| .|.| .|||.|           ... .  |. .. | | 
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRp
0050432 (Phosphotyrosine protein) phosphatases II 96-159 1.5e-09 33.1 In-house 202-267 (308) alignment 
Range on Protein: 96-159
Range on HMM: 202-267/308.0
YHKMKMAGRGVSPTQEDTDNFIKLVQEFHkkyPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGL
.| .     || |  |.  .|..||....   |. .. ||| .| .||| .||..|      .  .  .
fhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdv
0051299 (Phosphotyrosine protein) phosphatases II 79-164 2.5e-09 32.5 In-house 158-259 (288) alignment 
Range on Protein: 79-164
Range on HMM: 158-259/288.0
NTDRYYFREEVTEHE------------CIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDA
  | |  |.   ..              ..| ..    || .. |.  .|..||.....  .. .| ||| .| .||| .||..|      . ..  .  
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle

AIG
|. 
avk
subfamily_PTEN_pd Subfamily PTEN 107-172 6e-08 27.9 In-house 92-158 (184) alignment 
Range on Protein: 107-172
Range on HMM: 92-158/184.0
SPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLD-AAIGEFAENRQK
.|. |  ..... .... .. ...|| |||  |  ||| ||.|||..   .     |.  |||.| |
ppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk
0048567 (Phosphotyrosine protein) phosphatases II 104-174 7.4e-08 26.9 In-house 48-122 (157) alignment 
Range on Protein: 104-174
Range on HMM: 48-122/157.0
RGvSPTQEDTDNFIKLVQEFHK--KYPDRVVGVHCTHGF---NRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGI
 |  ..   . .||... .| |  .. .... |||..|     ||..||..||  .  .  . ||. ..  |.. .
fG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
PTPc_DSPc_SM00012 96-151 8e-08 27.8 In-house 5-61 (105) alignment 
Range on Protein: 96-151
Range on HMM: 5-61/105.0
YHKMKMAGRGVSPTQedtDNFIKLVQEFHKKYPD----RVVGVHCTHGFNRTGFLIAAYL
|| ...   ||  ..   |....|.....|.. .      | ||| .| .||| ..|...
yhytgwpdhgvPees...dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldi
subfamily_PRL_pd Subfamily PRL 88-173 1.4e-07 25.7 In-house 50-132 (151) alignment 
Range on Protein: 88-173
Range on HMM: 50-132/151.0
EVTEHECIYHKMKMAgRGVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGlDAAIgEFAENRQKG
.. ...   . ....  | .|..|  .....|..| .|. |...|.|||  |. |.  |.|  | .      . |. ||  ....|
klekegievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmky.edav.efirekrrg
subfamily_CDC14_pd Subfamily CDC14 33-162 2.6e-07 24.8 In-house 180-294 (328) alignment 
Range on Protein: 33-162
Range on HMM: 180-294/328.0
FFPFKTPlckmYDNQIAERRYQFH-PAEVFshPHLHGKKIGLWIDLTNTdrYYFREEVTEhECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFhkkypDRV
|  .  |     ... .| .|. | |....  .. . ...   . | .    | ... |. . . ||  .   |  |...   .|......      .  
flalagP....hnkskledgyplhaPekll..eyfrknnvttvvrLnkk..lYdakkftd.aGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa

VGVHCTHGFNRTGFLIAAYLFQveEYGLDAA
. |||  |. ||| |||.||..  .|.. ||
iavhCkaGLGrtGtLiacylmk..hyrftaa
subfamily_VSP_pd Subfamily VSP 108-159 6.2e-07 23.5 In-house 107-158 (212) alignment 
Range on Protein: 108-159
Range on HMM: 107-158/212.0
PTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGL
|. |.  .| | |.|. .| ...|. .||  | .||| .. |.|.. | .  
pkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifet