Gene cel-1 in Caenorhabditis elegans

Synonym: CELE_C03D6.3, cel-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily RNGTT
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP045_AA protein Get Run
CeleP045_AA_23-194 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_RNGTT_pd Subfamily RNGTT 16-205 2.2e-87 285.6 In-house 1-188 (189) alignment
Range on Protein: 16-205
Range on HMM: 1-188/189.0
PDRWLHCPKTGTLINNLFFPFKTPLCKMYDNQIAERRyQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDN
|.|||.||..|.||.. |.||||||.|.||...||.. .|.|....|. .....|.||.||||||.||| .||...... |.|...||.|..|..|....
PerWlnCPrkgkliaekflpfktplskrydddlaeen.rfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFARYDPTeDDKILAPEKPDWER
|||||.||.||.|..|.|||||||||||||||..||...|.....||. .||..|..||||.||...|..||. . ...| |||.|||..
fiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadv.eeaiaapelpdwcl

mRNA_cap_enzyme mRNA capping enzyme, catalytic domain 289-479 5.7e-70 224.2 Pfam-A 1-192 (192) alignment
Range on Protein: 289-479
Range on HMM: 1-192/192.0
QPVSLSRGNINLLEQESYMVSWKADGMRYIIYINDGDVYAFDRDNEVFEIENLDFVTKN-GAP---LMETLVDTEVIIDKVEIngamCDQPRMLIYDIMR
||||||| |..||.|..|.||.||||.|....|.. .||..||||||...|||.|..|. ...   ...||.|.|..||.||     ....|.|||||..
qpvslsrenlkllkqkdYyvseKaDGlRvlllitkkevylidrdnevylvenlkfplklekekekvhhgtllDGElvidtvee....eqklryliyDila

FNSVNVMKEPFYKRFEIIKTEIIDMRTAA-FKTGRLKHENQIMSVRRKDFYDLEATAKLFGPKFVQHVGHEIDGLIFQPKKTKYETGRCDKVLKWK
.|...|...|..||.||.|.|||..|... .||...|.|.. ..||.|.|..|.|..||.  |..... |||||||||...|.| .||....||||
ingelvserplskRleilkkeiikpraeeklkthiiktelepfkvrlksfilllalekllskkkikklsheiDGLIfqsvdtpYvagrdknllKWK

0038934 (Phosphotyrosine protein) phosphatases II 15-205 2e-53 176.2 In-house 2-190 (194) alignment
Range on Protein: 15-205
Range on HMM: 2-190/194.0
LPDRWLHCPKTGTLINNLFFPFKTPLCKMYDNQIAeRRYQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTD
||||||.....|..|.. | .||.||....|..|    |.|.|  ...  .|...|.||.||||||.||| .||.... . |.|. . ..|..|..| ..
lPdrwlkyervgdiitgrfiafkvPlsgsldkyie.elyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

NFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFARYDPTEDDKIlAPEKPDWER
.|..||.||... |. ||.|||..|..|||.|.||||...  . ...||. |.| |...|..|||...|. ||...... . |||||..  
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavl.apekpelll

subfamily_DSP11_pd Subfamily DSP11 15-185 1.8e-42 139.2 In-house 1-172 (178) alignment
Range on Protein: 15-185
Range on HMM: 1-172/178.0
LPDRWLHCPKTGTLINN-LFFPFKTPLCKMYDNQIAERRyQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVsPTQEDT
.|||| .  . |. |.   | .||||| . .|....| . .| | ..... . ..||.|| |||||||||| ..|.|...  |.|....|. | |..|  
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeek.rftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelv

DNFIKLVQEFH--KKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYIDDLFA
..|.. |.||   .|  |...||||||| ||||.||  || .||.|  . ||  | | |   . ...|..||  
kkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkk

mRNA_cap_C mRNA capping enzyme, C-terminal domain 482-585 2e-34 107.5 Pfam-A 1-105 (105) alignment
Range on Protein: 482-585
Range on HMM: 1-105/105.0
SHNSVDFLLKVEKKCKEGMLPEWIGYL-FVQNLSDPF----GTMKATATLKKYHNKIIECTLlvDNqgRPKEWKFMRERTDKSLPNGLRTAENVVETMVN
..|.||||||.||....|.|.|. |.| .|.. ||.|     ..|.....|....||.||.|  |.  . ..|||.|.|.||| ||...|||.|.... .
elntvDfllklekeeedglLeeekgkldyveggsdefitakekeklksdekelkgkIvEckl..dd..kkgrWkflriRkDKsepNsistaekvlksied

PVTETYLIE
.||...|.|
nvtkeeLle

0036282 (Phosphotyrosine protein) phosphatases II 25-183 2.2e-24 81.5 In-house 11-162 (174) alignment
Range on Protein: 25-183
Range on HMM: 11-162/174.0
TGTLINNLFFPFKTPLCkmydnqIAERRYQFHPAEVFSHPHLHGKKIGLWIDLTNTDRYYfreeVTEHECIYHKMKMAGRGVSPTQEdTDNFIKLVQEFH
 .. |.. .. .. ||.        |  ....   |..  ... ......|......|..     ... . |... . ..|| ....  ..|.|.|.|..
dlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsi.llefvkfveeal

KKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEY-GLDAAIGEFAENR---QKGIYKQDYIDDL
.. |...| |||..|..|||.|.||||  .  . .|. |.  ..| |    .... ....  |
sedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl

0044763 (Phosphotyrosine protein) phosphatases II 56-184 4.6e-21 70.7 In-house 22-164 (178) alignment
Range on Protein: 56-184
Range on HMM: 22-164/178.0
HPAEVF------------SHPHLHGKKIGLWIDLTNTDRYY----FREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHG
.. |..              . |.  .|.....||......    ... ..|... |... . . || .  | ...|.....|...  ....| |||..|
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaG

FNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQkGIYKQDYIDDLF
..|.| |.||||  .  . |..|| .. | |  ... ....  | 
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLy

PTEN_1 10-175 1e-20 69.4 In-house 10-176 (196) alignment
Range on Protein: 10-175
Range on HMM: 10-176/196.0
KARMGLPDRWLHCPKTGTLINNLFFPFKTPLCKmydnQIAERRYQFHPAEVFSHP-HLHGKKIGLWIDLTNTDRY----YFREEVTEHECIYHKMKMAGR
| .. ||...| ..   . |   .... .||..    .| |..|. .  .| ..  .|....| |...|.. . .    |  ||  .. ..|... .   
kknlalptelldltyitsriiamgkapsrpllq....eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDh

GVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIY
|... .|  |   .. .   .. . .|| |||..| .|.|...|||| . . .  | |.  ..| | .|  
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgap

0041856 (Phosphotyrosine protein) phosphatases II 63-176 1.1e-19 66.2 In-house 51-156 (182) alignment
Range on Protein: 63-176
Range on HMM: 51-156/182.0
HPHLHGKKIGLWIDLTntDRYYFREEVTEHECIYHKMKMAGRGVSPtQEDTDNFIKLVQEfhkkyPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAA
 . |.. .|.. ..||  ...|. |... . . |... . . || .  ... .||. |.|     ....| |||..| .|||.|.||||  . ...|. |
lrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklgvsleea

IGEFAENRQKGIYK
. .. . | ...  
vklvrsrRpgmvit

0043147 (Phosphotyrosine protein) phosphatases II 66-181 1.2e-19 66.1 In-house 40-151 (172) alignment
Range on Protein: 66-181
Range on HMM: 40-151/172.0
LHGKKIGLWIDLTntDRYYFREEVTEHECIYHKMKMAGRGVSpTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQvEEYGLDAAIGE
|. ..|.....||  ...| .| .... . |. . .   ||  . |  ..|.....|.. ..|. .| |||..|..|||.|.|||| . . . |. |. .
lkelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeaval

FAENRQKGIYKQDYID
. | | .... .... 
vrekRpgavqnpsqyr

0040439 (Phosphotyrosine protein) phosphatases II 42-180 2.6e-19 65.3 In-house 6-235 (249) alignment
Range on Protein: 42-180
Range on HMM: 6-235/249.0
KMYDNQIAERRYQFHPAEVFSHPHLHG--------------------------------------------KKIGLWIDLTNTDRY--------------
 .. . .  .||. ...  .| ..|.                                              .|.  ..||.....              
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggs

-----------------------------YFREEVTEHECIYHKMKmaGRGVSPTQEDTDNFIKLVQEFHKKY-PDRVVGVHCTHGFNRTGFLIAAYLF-
                             |. |..| .   |...     ||.|. ||...||..|....... .. .| |||..| .|||..|||||  
leygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp..dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

----QVEEYGLDAAIGEFAENRQKGIYKQDYI
       .. |. |. .. . | .... ....
eqlekelgvdleeavkllrsqRpgavqnpeqy

0048076 (Phosphotyrosine protein) phosphatases II 61-184 2.8e-19 64.7 In-house 20-136 (145) alignment
Range on Protein: 61-184
Range on HMM: 20-136/145.0
FSHPHLHGKKIGLWIDLTNTDRYYFreevtEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLD
 . ..|.  .|.....||.. ....     .. . |. . . ..|| .  |. ..|.....|..|.  ...| |||..| .|||.|.||||   . . |.
ldlellkdlgittvlnltselelle.....rlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmlllgvsle

AAIGEFAENRQKGIYKQDYIDDLF
 |. .. . | .... ....  |.
ealelvrsqrpgavpnpgqlrfly

0048179 (Phosphotyrosine protein) phosphatases II 60-183 2.4e-18 61.7 In-house 19-137 (144) alignment
Range on Protein: 60-183
Range on HMM: 19-137/144.0
VFSHPHLHGKKIGLWIDLTNTdryYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkyPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGL
. . ..|.  .|...|.||..   |  |... . . |... . ..|| .  |. ..|.....|...  ....| |||..|..|||.|.||||  .. . |
aldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsl

DAAIGEFAENRQKGIYKQDYIDDL
. |. .. . |  ... ....  |
eealalvrsrrpgavpnpgqlrfL

0049260 (Phosphotyrosine protein) phosphatases II 69-184 1.2e-17 59.4 In-house 30-143 (152) alignment
Range on Protein: 69-184
Range on HMM: 30-143/152.0
KKIGLWIDLTNTDRYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFhKKYPDRVVGVHCTHGFNRTGFLIAAYLFQvEEYGLDAAIGEFAE
|. | .. .. |..... .. .|.   |. . .   || .  .  . ........ ..... .| |||..|..|||.|.||||     . |. |.  . |
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvre

NRQKGIYKQDYIDDLF
 | .... ....  |.
kRpgavpnpgqlrfly

0049772 (Phosphotyrosine protein) phosphatases II 37-171 3.8e-17 58.4 In-house 145-255 (314) alignment
Range on Protein: 37-171
Range on HMM: 145-255/314.0
KTPLCKMYDNQiaerryqfhpaevfshPHLHGKKIGLWIdltntDRYYFREEVTEHECIYHKMKMAGrGVSPTQEDTDNFIKLVQEFhkkYPDRVVGVHC
||||...  |.                .... . . |.      ...| .| ....   |. . . . |  |. || | |.....|.    ....| |||
Ktpllildgng................neptaadlellk.....eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHC

THGFNRTG-FLIAAYLFQVEEYGLDAAIGEFAENRQ
..| .||| |..||||     . |. |. .. . | 
kaGkgRtgtfvvaaylmkllgvsleealedvrlkRp

0037934 (Phosphotyrosine protein) phosphatases II 65-180 9.3e-17 56.8 In-house 67-231 (243) alignment
Range on Protein: 65-180
Range on HMM: 67-231/243.0
HLHGKKIGLWIDLTNTD----------------------------------------RYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFH
 |.  .|.  ..||...                                        ...  ...| . . || . . . || .. ||  .|.. |.|| 
mlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefi

KK-------YPDRVVGVHCTHGFNRTGFLIAAYLFQVE-EYGLDAAIGEFAENRQK-GIYKQDYI
..        ....| |||..| .||| ||||||     ...|. |. .. | |   ..  ....
eellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqy

0045450 (Phosphotyrosine protein) phosphatases II 66-180 1.2e-16 56.8 In-house 127-293 (307) alignment
Range on Protein: 66-180
Range on HMM: 127-293/307.0
LHGKKIGLWIDLTNTDRY-----------------------YFREEVTEHECIYHKMKM--------------------AGRGVSPTQEDTDNFIKLVQE
|. ..... ..||... .                       ....| ............                     . ||.|. |.. .||..|..
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

FHKKY-PDRVVGVHCTHGFNRTGFLIAAYLFQVEE--------YGLDAAIGEFAENRQKGIYKQDYI
..... .. .| |||..| .||| .|||||  .          . |. |. .. | | ...  ....
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

0039614 (Phosphotyrosine protein) phosphatases II 67-175 2.5e-15 52.2 In-house 122-273 (297) alignment
Range on Protein: 67-175
Range on HMM: 122-273/297.0
HGKKIGLWIDLTNTDRY--------------------YFREEVTEHECI-----------------YHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKY-P
.  ..   . ||... .                    ..... ... ..                 .. ...   || |. |. ..|..||.|..... .
weqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

DRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIY
...| |||..| .||| .|||||         .. .. |. |. | | ... 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavq

0042113 (Phosphotyrosine protein) phosphatases II 75-179 3.7e-15 51.5 In-house 81-231 (245) alignment
Range on Protein: 75-179
Range on HMM: 81-231/245.0
IDLTNTDRYYF-----------------------------------------REEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKYPDRVVG
..||... . .                                         ..  . . . || . . . || .. |. ..|...|... .. .. .| 
vmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvl

VHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIYKQDY
|||..| .||| .|||||         .. |. |. |. . | . .  ...
VHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsq

0040438 (Phosphotyrosine protein) phosphatases II 67-179 4.7e-15 51.1 In-house 107-264 (317) alignment
Range on Protein: 67-179
Range on HMM: 107-264/317.0
HGKKIGLWIDLTNTDRY----------------------YFREEVTEHECIYHKMKM-------------------AGRGVSPTQEDTDNFIKLVQEFHK
.  .... . ||... .                       ...|.............                      || |. ..  .|...|.|. .
weqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale

kYPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIYKQDY
  |. .| |||..| .|||..|||||      . ... .. |. |. | | ....  ..
.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeq

0051082 (Phosphotyrosine protein) phosphatases II 64-172 4.5e-14 47.8 In-house 27-134 (151) alignment
Range on Protein: 64-172
Range on HMM: 27-134/151.0
PHLHGKKIGLWIDLTNTD-RYYFREEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHGFNRTGFLIAAYLFQvEEYGLDAA
. |.  .|   ..|.... |.|. | ..|..  .. . . .  . .... .| ........ .  .. .| |||..| .|||.|.|.||   . . |..|
ellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylml.lgvsleea

IGEFAENRQK
. |. . |  
leeyrlkrpg

0046846 (Phosphotyrosine protein) phosphatases II 71-174 6.1e-13 44.4 In-house 48-156 (176) alignment
Range on Protein: 71-174
Range on HMM: 48-156/176.0
IGLWIDLTNTD------RYYFREEVTEHECIYHKMKMAGRGVSPTqEDTDNFIKLVQEFHKKYpdRVVGVHCTHGFNRTGFLIAAYLFQV-EEYGLDAAI
|.. ..||.         ... .|...... |. . .   || .  |. ........|. |.   ..| ||| .| .||| |.|||| .    . .. |.
itavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveeal

GEFAENRQ-KGI
 .. | |  . .
alvreqRplgav

0043336 (Phosphotyrosine protein) phosphatases II 86-175 1e-12 43.6 In-house 168-261 (278) alignment
Range on Protein: 86-175
Range on HMM: 168-261/278.0
REEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIY
..  . . ..|| ...   || .. ..  .|.| |.|. .  .. .| |||..| .||| .||.||         .. |. |. |. | | . . 
gdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavq

DSPc Dual specificity phosphatase, catalytic domain 65-179 2.2e-11 38.7 Pfam-A 13-123 (133) alignment
Range on Protein: 65-179
Range on HMM: 13-123/133.0
HLHGKKIGLWIDLTNTDRY-YFREEVTEHECIYH--KmkmagRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDA
 |  ..| | |..|.. .  .....   ..  .            . .... .. .. ......|   . | |||..| .|.. ||.||| . ... |. 
lleklgitlvinvtkevpnnnaikkseieylripved.....etetkiskeleeavefiekaeqk..gkkvlVHCqaGisRSatliiaYlmktknlslne

AIGEFAENRqKGIYKQ-DY
|.  . |.| . | ..  .
Ayefvkerr.skispnagf

DSPc Dual specificity phosphatase, catalytic domain 65-179 2.2e-11 38.7 In-house 13-123 (133) alignment
Range on Protein: 65-179
Range on HMM: 13-123/133.0
HLHGKKIGLWIDLTNTDRY-YFREEVTEHECIYH--KmkmagRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDA
 |  ..| | |..|.. .  .....   ..  .            . .... .. .. ......|   . | |||..| .|.. ||.||| . ... |. 
lleklgitlvinvtkevpnnnaikkseieylripved.....etetkiskeleeavefiekaeqk..gkkvlVHCqaGisRSatliiaYlmktknlslne

AIGEFAENRqKGIYKQ-DY
|.  . |.| . | ..  .
Ayefvkerr.skispnagf

0046845 (Phosphotyrosine protein) phosphatases II 76-175 3.6e-11 38.5 In-house 141-258 (284) alignment
Range on Protein: 76-175
Range on HMM: 141-258/284.0
DLTNTDRYYFR---------EEVTEHECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKK-YPDRVVGVHCTHGFNRTGFLIAAYLFQVE--------EY
. .. | |  |         .. . .  ..| ..   .|| |. ||  .|..||.|.... ... .. ||| .| .||| .||..|            ..
seevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgv

GLDAAIGEFAENRQKGIY
 .  |.  . | |   . 
dvleavkrlreqRpgmvq

0045098 (Phosphotyrosine protein) phosphatases II 75-172 4.3e-11 38.2 In-house 137-252 (278) alignment
Range on Protein: 75-172
Range on HMM: 137-252/278.0
IDLTNTDRYYFREEVTEHECIYHKM-KMAGRGVSPTQ--EDTDNFIKLVQEFHK------------KYPDRVVGVHCTHGFNRTGFLIAAYLFQVE---E
..|. |. .. ||. ....  ....  .   || ..      ..... ..|..|              .. .| ||| .| .||| |.||||        
rtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlellegg

YGLDAAIGEFAENRQK
. |. |. |. . |  
vdlleavkelrsqRpg

DNA_ligase_A_M ATP dependent DNA ligase domain 303-479 1.2e-10 30.2 Pfam-A 18-202 (202) alignment
Range on Protein: 303-479
Range on HMM: 18-202/202.0
QESYMVSWKADGMRYIIYINDGDVYAFDRDNEVFEI---ENLDFVTKNGAPL-METLVDTEVII-D--------KVEINGA----------MCDQPRMLI
.. ..|..| || | ..  ....|... |  . .     | |... .  ..   . ..| |... |          ..             .  ......
egafiveeKyDGeRvqvhkdgdevkllSRrgkditakkpellkalkeaflkdvksvildGElvavdketgeilpfqtlasrknkkkvkveekeaelsffv

YDIMRFNSVNVMKEPFYKRFEIIKTEIidmrtaafktgrLKHENQIMSVRRKDFYDLEATAKLFgpkfVQHVGHEIDGLIFQPKKTKYETGR-CDKVLKW
.|.. .. .....||. .|...... .             . ||.|  .. .. .|.|  ..|.     . . .. .|...  .. ||| |. . . || 
FDvlyldgesltdepleeRrklLeeif............kesenrieiaetlevndveeleell....eevikeglEGvvlKdpdskYepgkrssnwlKl

K
|
K

0051429 (Phosphotyrosine protein) phosphatases II 62-178 2.3e-10 36.1 In-house 37-212 (272) alignment
Range on Protein: 62-178
Range on HMM: 37-212/272.0
SHPHLHGKKIGLWIDLTNTDRYYFRE-EVTEHECIYHKMKMAGRGVSPTQ--------------------------------------------------
. ..|.  .|   .||.... . .   .   . . |. . . .... .                                                    
dfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvp

-EDTDNFIKLVQEfhkkypDRVVGVHCTHGFNRTGFLIAAYLFQvEEYG--------------LDAAIGEFAENRQKGIYKQD
 |   ....|...      .. | |||..| .|||...|..|   .  .              |..|. |  . | . .  ..
qeallellellld......ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqtee

0047943 (Phosphotyrosine protein) phosphatases II 92-175 2.6e-10 35.7 In-house 167-256 (273) alignment
Range on Protein: 92-175
Range on HMM: 167-256/273.0
HECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKY-PDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDAAIGEFAENRQKGIY
. ...| ..    || |. |.  .||.||.......  . .| ||| .| .||| .||..|         .  .. |.  . . |  ...
tvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvq

PTPc_motif_SM00404 66-180 4.2e-10 34.7 In-house 23-131 (140) alignment
Range on Protein: 66-180
Range on HMM: 23-131/140.0
LHGKKIGLWIDLTNTDRYYfreevtE--HECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAI
|  ..| . |..|.. .        .   .  . ....   ........ |. .. .....||   . | |||..| .|.. ||.||| . ... |..|.
lkklgithvinvteevslt......kensgfqilqiplddnekdklskyldkvldfienaekk..ggkvlVHCqaGvSRSatliiaYlmryrqlslaeay

GEFAENRqKGIYKQ-DYI
  . |.| . | ..  ..
efvkerR.piispnlnfv

subfamily_PTPDC1_pd Subfamily PTPDC1 84-181 5.3e-10 34.0 In-house 73-166 (182) alignment
Range on Protein: 84-181
Range on HMM: 73-166/182.0
YFREEVTEHECIYHKMKMAGRGVSPTQEdTDNFIKLVQEFHKKYpdrVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGIYKQDYID
|  |...|.. ..... ..  || . ..   . .|.|.   ..     |.|||  |  ||| |||.||  ....  . ||    ..| | |. .. ..
YdlealmeqgiyvynfgwkDygvasler.iLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqve

subfamily_DSP23_pd Subfamily DSP23 106-173 7.1e-10 33.7 In-house 63-128 (148) alignment
Range on Protein: 106-173
Range on HMM: 63-128/148.0
VSPTQEDTDNFIKLVQEFHKKypDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKG
  |. |. ..|...|.| ..|  .  |.|||  |. ||| ..| || . ..     || |  . |   
hppaleqvvefvrvveeaeek..neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgs

0036941 (Phosphotyrosine protein) phosphatases II 94-171 1.2e-09 33.4 In-house 171-257 (297) alignment
Range on Protein: 94-171
Range on HMM: 171-257/297.0
CIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKKY-PDRVVGVHCTHGFNRTGFLIAAYLF--------QVEEYGLDAAIGEFAENRQ
 ..| ..    || .. ..  .||.||....|.. .. .| ||| .| .|.| .|||.|           ... .  |. .. | | 
thfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRp

0050432 (Phosphotyrosine protein) phosphatases II 96-159 1.5e-09 33.1 In-house 202-267 (308) alignment
Range on Protein: 96-159
Range on HMM: 202-267/308.0
YHKMKMAGRGVSPTQEDTDNFIKLVQEFHkkyPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGL
.| .     || |  |.  .|..||....   |. .. ||| .| .||| .||..|      .  .  .
fhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdv

0051299 (Phosphotyrosine protein) phosphatases II 79-164 2.5e-09 32.5 In-house 158-259 (288) alignment
Range on Protein: 79-164
Range on HMM: 158-259/288.0
NTDRYYFREEVTEHE------------CIYHKMKMAGRGVSPTQEDTDNFIKLVQEFHKkYPDRVVGVHCTHGFNRTGFLIAAYLF-----QVEEYGLDA
  | |  |.   ..              ..| ..    || .. |.  .|..||.....  .. .| ||| .| .||| .||..|      . ..  .  
vlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle

AIG
|. 
avk

subfamily_PTEN_pd Subfamily PTEN 107-172 6e-08 27.9 In-house 92-158 (184) alignment
Range on Protein: 107-172
Range on HMM: 92-158/184.0
SPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGLD-AAIGEFAENRQK
.|. |  ..... .... .. ...|| |||  |  ||| ||.|||..   .     |.  |||.| |
ppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtk

0048567 (Phosphotyrosine protein) phosphatases II 104-174 7.4e-08 26.9 In-house 48-122 (157) alignment
Range on Protein: 104-174
Range on HMM: 48-122/157.0
RGvSPTQEDTDNFIKLVQEFHK--KYPDRVVGVHCTHGF---NRTGFLIAAYLFQVEEYGLDAAIGEFAENRQKGI
 |  ..   . .||... .| |  .. .... |||..|     ||..||..||  .  .  . ||. ..  |.. .
fG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv

PTPc_DSPc_SM00012 96-151 8e-08 27.8 In-house 5-61 (105) alignment
Range on Protein: 96-151
Range on HMM: 5-61/105.0
YHKMKMAGRGVSPTQedtDNFIKLVQEFHKKYPD----RVVGVHCTHGFNRTGFLIAAYL
|| ...   ||  ..   |....|.....|.. .      | ||| .| .||| ..|...
yhytgwpdhgvPees...dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldi

subfamily_PRL_pd Subfamily PRL 88-173 1.4e-07 25.7 In-house 50-132 (151) alignment
Range on Protein: 88-173
Range on HMM: 50-132/151.0
EVTEHECIYHKMKMAgRGVSPTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGlDAAIgEFAENRQKG
.. ...   . ....  | .|..|  .....|..| .|. |...|.|||  |. |.  |.|  | .      . |. ||  ....|
klekegievldlafd.dGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGmky.edav.efirekrrg

subfamily_CDC14_pd Subfamily CDC14 33-162 2.6e-07 24.8 In-house 180-294 (328) alignment
Range on Protein: 33-162
Range on HMM: 180-294/328.0
FFPFKTPlckmYDNQIAERRYQFH-PAEVFshPHLHGKKIGLWIDLTNTdrYYFREEVTEhECIYHKMKMAGRGVSPTQEDTDNFIKLVQEFhkkypDRV
|  .  |     ... .| .|. | |....  .. . ...   . | .    | ... |. . . ||  .   |  |...   .|......      .  
flalagP....hnkskledgyplhaPekll..eyfrknnvttvvrLnkk..lYdakkftd.aGfdhkDlffiDGstPsdaivkkfleiaeka.....eGa

VGVHCTHGFNRTGFLIAAYLFQveEYGLDAA
. |||  |. ||| |||.||..  .|.. ||
iavhCkaGLGrtGtLiacylmk..hyrftaa

subfamily_VSP_pd Subfamily VSP 108-159 6.2e-07 23.5 In-house 107-158 (212) alignment
Range on Protein: 108-159
Range on HMM: 107-158/212.0
PTQEDTDNFIKLVQEFHKKYPDRVVGVHCTHGFNRTGFLIAAYLFQVEEYGL
|. |.  .| | |.|. .| ...|. .||  | .||| .. |.|.. | .  
pkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifet