Gene daf-18 in Caenorhabditis elegans

Synonym: CELE_T07A9.6, daf-18

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP048_AA protein Get Run
CeleP048_AA_46-221 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTEN_pd Subfamily PTEN 49-230 4.2e-82 269.6 In-house 2-182 (184) alignment
Range on Protein: 49-230
Range on HMM: 2-182/184.0
FRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHgKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAP
.|..||....|......|||..|||..|||.||||...||..|||. ....||...| |...|..|||....||...|||.|......||.||.|||...
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkh.kdhykiynlrserkydskkfdgrvavypfdDhnppplellee

FCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERE
.......|||.|.|.|..||||||||||||.|.|.|............|.... .||||.|||||||||||..||.|| |.|
ivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee

subfamily_VSP_pd Subfamily VSP 43-238 2.6e-45 148.9 In-house 10-209 (212) alignment
Range on Protein: 43-238
Range on HMM: 10-209/212.0
ERIRHIFRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHgKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPS
...... |  || |. | . . .||| .|.|.||||. .|..| .. .||   .  .|| ..| . . ||.||     ||   |. .|.   . ||  |.
rklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkh.rdhykvvnlcseraydekyfnnrvkriliddhnvpk

LELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNN-----KGVTIPSQRRYIYYYHKLRERELNYLPLR
|| .  |..|.|||||.| |.|.|.||| |||||| ..||||.. . . . .. |||..  ||...     .||  |||.||. |.... ..  . || .
leellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktkynrklppa

M
 
k

PTEN_1 61-228 5.5e-42 138.8 In-house 14-193 (196) alignment
Range on Protein: 61-228
Range on HMM: 14-193/196.0
EYQNIDLDCAYITDRIIAIG-YPATG-----IEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGY-----YYDADN-FDGNVI--CFDMTDHHPPSLELM
 . . .||..|||.|||| |  |...     .|  .|.|  . ...| .....|   |.||  ..      || .  |...|.   |...||..|||. .
alptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslsel

APFCREAKEWLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYSIIRTKNNKGvtIPSQRRYIYYYHKLRE
  .|....||| .|. ..|..||||||.||.|....|.|.| .   .... |... . |.....   .|||.|...|...|..
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaella

subfamily_Tensin_pd Subfamily Tensin 62-233 1e-39 129.0 In-house 6-179 (189) alignment
Range on Protein: 62-233
Range on HMM: 6-179/189.0
YQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKgNVKVFNLRGgYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADD
 ...|||  |||.||||. .||.| |...|..  .  ..| ..|.. .. ||||     || .... .|. |   |.. |||| ..  |.. ..||.|| 
eekvdldltyiteriialsfpaegleekyrenlkdvakllkskhnd.kylvfnlse.krydisklnkkvldfGWPdllaPsleklcsicksldsWlkadp

KHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNK--GVTIPSQRRYIYYYHKLRERE--LNY
..|..|||| ||||.||.. | . | .   |  . || ... |  ..|  |.| ||||||. |. .| . .  || 
qnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklns

0036282 (Phosphotyrosine protein) phosphatases II 66-226 1.4e-37 124.5 In-house 9-168 (174) alignment
Range on Protein: 66-226
Range on HMM: 9-168/174.0
DLDCAYITDRIIAIGYPATgIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVI
.||  |||.|.|| ..|..   . ... ...|   |.. . .|..|..|.   ...|  ... ..... . ||..|.|. .  |.....|.|. |.....
pldlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

AVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKL
.|||.||.||||....|.|.. . ..|....||..  .|... ..|..|||.|..||..||
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl

subfamily_Auxilin_pd Subfamily Auxilin 61-226 6.9e-36 116.5 In-house 3-163 (166) alignment
Range on Protein: 61-226
Range on HMM: 3-163/166.0
EYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHgKGNVKVFNLrGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEAD
.| . ||| .||| ||| . .|| |.|  ..|.  . ..||  || ... .|.|| ..  |....... |.   .. .. |.|| .   ||.   ||..|
syakndlDisyitsriivmsfPaegvestyknniddvrsfLesrh.pekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

DKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNkgvTIPSQRRYIYYYHKL
 |.|. |||| |.  ..|...|||.... ...| . .. .|. |.  .     ||..||..|  .|
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig...lspsekryleyladl

0038934 (Phosphotyrosine protein) phosphatases II 63-225 4.4e-31 103.4 In-house 7-168 (194) alignment
Range on Protein: 63-225
Range on HMM: 7-168/194.0
QNIDLDCAYITDRIIAIGYPATG-----IEANFRNSKVQTQQFLTRRHgKGNVKVFNLR-GGYYYDADNFDGNVI---CFDMTDH-HPPSLELMAPFCRE
....    .||.|.||...|..|     ||   |.|     ..|. .. .....| .|.  . |||.. | .. |    . . |. ..||||..  |.. 
lkyervgdiitgrfiafkvPlsgsldkyieelyrfspedlvrylklln.vklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldl

AKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILDYYSIIRtknnkgvtiPSQRRYIYYYHK
..|.|..| ..|.|||||||.||||....| ||| . . |... .......|         |.. ... |.. 
vdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdylea

PTEN_C2 C2 domain of PTEN tumour-suppressor protein 234-530 4.8e-31 98.7 Pfam-A 2-134 (134) alignment
Range on Protein: 234-530
Range on HMM: 2-134/134.0
LPLRMQLIGVYVERPPKT-WGGGSKIKVEVGNGSTILFkpdpliisksnhqreratwlnncD----------TpnefdtgeqkyhgfvskRAYCFMVPED
 |.|..| ....|..|.   .|| |.||.| ||.. .|                       .          .                 ||..|.|.|.
npkrlelksiilegiPnfktrggckpkvkvyngkkkvf.......................kelasykdster.................raktfivkep

APVFVEGDVRIDIREIGfLKKFSDGKIGHVWFNTMFACDgglngghfeyvdktqpyigddtsigrkngmrrnetpmrkidpetgnefespwqivnppgle
 ...|||||.... . .  |. .. ||..|||||.| ..                                                             
nrlpveGDvlveflhkd.sklpkkekifrvwFNTsFiek.............................................................

khiteeqamenytnygmipprytiskilhekhekgivkddyndrklpmgdksytesgksgdirgvggpfeipykaEEHVLTFPVYEMDRALKS--KDLNN
                                                                           ...|||.|..|.|.|||   | ...
...........................................................................nqnvltlpkneLDkalkdkdkkfsk

GMKLHVVLRC
..|...|...
nfkvelvfek

0046846 (Phosphotyrosine protein) phosphatases II 63-226 2.3e-29 97.8 In-house 6-171 (176) alignment
Range on Protein: 63-226
Range on HMM: 6-171/176.0
QNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRrhgkGNVKVFNLRGG--------YY--YDADNFDGNVICFDMTDHHPPSLELMAPFCRE
   |||. ||....|. ..|... .   |.     ....      |   |.||           ..   .  ...  ...... ||..|.|||.  ....
lgldldldyinanlilgsrpiatqgplprtladflemlkel....gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellef

AKEWLEADdkHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKnnKGVTIPSQRRYIYYYHKL
 .|.|...  ....|||.||.||||....|.|.. ..  |. ..|...  .| .  . |. |.|.|..|....|
irealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefell

0041856 (Phosphotyrosine protein) phosphatases II 63-229 2.5e-29 97.6 In-house 8-172 (182) alignment
Range on Protein: 63-229
Range on HMM: 8-172/182.0
Q-----NIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRgGYYYDADNFDG---NVICFDMTDHHPPSLELMAPFCREAK
.     . ..|. ||...... ..||| ..|  .. . .. .||.  .. |   . ||. ...|.....     ..... . ||..|.|. .  |..|..
sdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfieevl

EwleadDKHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYYHKLRER
|     ......|||.||.||||....| |.. .   |........   |   ...|..|.| ......  .. .
e.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqlallelll

0039614 (Phosphotyrosine protein) phosphatases II 48-224 1.1e-28 96.1 In-house 24-285 (297) alignment
Range on Protein: 48-224
Range on HMM: 24-285/297.0
IFRTAVSSNRCRTEYQNI----------------------------------------DLDCAYI-----------TDRIIAIGYPATGIEANFRNSKVQ
 ...| |......|....                                        |||. ||           |...|| ..| ..  ..| .   .
llekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

TQ---------------------------------QFLTRRHgKGNVKVFNLRGGYyYDADNFDGNVICFDMTDHHPP-SLELMAPFCREAKEWLEAD-D
 .                                  .|.  | .....|..|.  . ..   .   . .... ||..| ||||.  |.....|.|... .
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

KHVIAVHCKAGKGRTGVMICALLIY----INFYPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYYH
.....|||.||.||||..|.|.|..     .  ... ......   |   ...|..||| |..|.. 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR...pgavqtpsqyrflydal

0043147 (Phosphotyrosine protein) phosphatases II 66-228 5.1e-28 93.3 In-house 12-161 (172) alignment
Range on Protein: 66-228
Range on HMM: 12-161/172.0
DLDCAYITDRIIAIGYPatgieanFRNSKVQTQQFLTRRHGKGnvkVFNLRgGYYYDADNF---DGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDK
.||. ||.||.||  .|       .||   .  ..| ... .    ..||  . .||....   .  .... . ||..|.|||.  |..  .|.|  ...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith...ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefidellalspg

HVIAVHCKAGKGRTGVMICALLIYINFypsprQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRE
....|||.||.||||....|.|.. ..      ... .. .|.| ...|..|||.|..||..||. 
gpvlVHCsaGvgRtgtlvaaylmllgl.....sleeavalvrekRpgavqnpsqyrflyyfeklll

0043336 (Phosphotyrosine protein) phosphatases II 15-223 1.1e-27 92.7 In-house 21-272 (278) alignment
Range on Protein: 15-223
Range on HMM: 21-272/278.0
SMARDLQENPNRQPGEPRVSEPYHNSIVERIRHIFrtAVSSNRCRTEYQNIDLDCAYI----------TDRIIAIGYPATGIEANFRNS-----------
 . .. .| .. .... .... ..|    |...|.  .  ..| . .  . |||. ||          ....|| ..| .. ...|..            
llllefeellsfkldtysiallpenkdknrykdil..pydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivm

--------------------------KVQTQQFLTrrhgKGNVKVFNLRGGYYYDADNFDGN-VICFDMTDHHPP-SLELMAPFCREAKEWLEaDDKHVI
                          .| .. . .    .....|..|.  ...|   . .. . .... ||. | ||.|.  |.....|.|| |.....
LtelvelgrvkcaqYwpggsltygdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpv

AVHCKAGKGRTGVMICALLIY----INFYPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYY
.|||.||.||||..|...|..     .  ... ......   |    . |. ||| |..|..
lVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR...pgavqtpsqyrflyea

0037934 (Phosphotyrosine protein) phosphatases II 62-225 3.4e-27 91.0 In-house 32-239 (243) alignment
Range on Protein: 62-225
Range on HMM: 32-239/243.0
YQNIDLDCAYITDRIIAIGYPATGIEANfrnskvQTQQFLTRRHGKGNVKVFNLRGGY------------------------------------------
   |...  |.|.|.|| ..| ..  ..       . .|.   .  |   . .|.  .                                          
sdyinanliyvtprliatqgPlpetved......dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen

--YYDADNFDGNVICFDMTDHHPPS-LELMAPFCREAKEWLEA-------DDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKnnK
  ..|   .. .. .. . ||..|.  | .  |..|..|..|.       |......|||.||.||||..|.|.|.. ..  .. ......   |    |
ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg..k

GVTIPSQRRYIYYYHK
.|..|||.|..|....
avqtpsqyrflyeall

0040438 (Phosphotyrosine protein) phosphatases II 58-260 2.1e-26 88.4 In-house 47-308 (317) alignment
Range on Protein: 58-260
Range on HMM: 47-308/317.0
C-------------RTEYQNIDLDCAYI----------TDRIIAIGYPATG--------------------------------------IEANFRNSKVQ
.             .    . |||. ||          ....|| ..|  .                                       . .. . .|.
nrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvt

TQQFLTrrhgKGNVKVFNLRGGYYYDADNFDGNVICFDM-TDHHPP-SLELMAPFCREAKEWLEaDDKHVIAVHCKAGKGRTGVMICALLI-----YINf
.... .    ........|.  ...| . .  .....   .||..| |..|.  |.....|.|| |......|||.||.||||..|.|.|.     . . 
llseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.

YPSPRQILDYYSIIRtknNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQLIGVYVERPPKTWGGGSKIKV
 ... ......   |   ...|. |.| |..|...    .  ..|.  ..|.  ..... . .....|.|.
gvdveeavkelreqR...pgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklke

0049260 (Phosphotyrosine protein) phosphatases II 103-226 2.2e-26 87.7 In-house 30-148 (152) alignment
Range on Protein: 103-226
Range on HMM: 30-148/152.0
RRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYinfypSPRQILDYYSI
...| . . . . .   ...  ..  ..... . ||..|.|. . .|. .. |.|  |......|||.||.||||....|.|..         ...... 
kelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.....lgvsleeaval

IRTKNNKGVTIPSQRRYIYYYHKL
.|.|....|. |.|.|..|...||
vrekRpgavpnpgqlrflyefekl

0042113 (Phosphotyrosine protein) phosphatases II 53-225 2.6e-26 87.9 In-house 21-240 (245) alignment
Range on Protein: 53-225
Range on HMM: 21-240/245.0
VSSNRCRTEYQNIDLDCAYI----------TDRIIAIGYPATGIEA--------------------------------------NFRNSKVQTQQFLTrr
  ..| .    . |||. ||          |...|| ..|...  .                                      .. . .|..  . .  
ydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseeh..

hgKGNVKVFNLRGGY-YYDADNFDGNVICFDMTDHHPPS-LELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIY----INFYPSPRQILD
  .....|..|.  . ..|   .. .. .... ||..|. |||.  |.......|..|......|||.||.||||..|.|.|..     .   |. ....
..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavk

YYSIIRtknNKGVTIPSQRRYIYYYHK
..   |    . |..||| |..|....
elrsqR...pgavqtpsqyrflyeall

0049772 (Phosphotyrosine protein) phosphatases II 69-231 3.8e-25 84.7 In-house 121-281 (314) alignment
Range on Protein: 69-231
Range on HMM: 121-281/314.0
CAYITD---------------------RIIAIGYPatgieanfrnskvqtqQ--------FLTrrhgkgnvkvfnlrgGYYYDADNFDGNVICF---DMT
. .|                        .|. |..                         .|                . .||.. | ...| .   ...
vrdivmsrdevladelsrLdaAlgKtpllildgng................neptaadlellk...............eelydpelferlgikylripvp

DHHPPSLELMAPFCREAKEWleaDDKHVIAVHCKAGKGRTGV-MICALLIYINFYpSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLREREL
|...|.|| .  |..  .|.   |......|||||||||||. ...|.|.. . . |....|...  .|. | . ..|.....|..... |.|.  
Dgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRpinpnpgfieqleqyefilealleylk

0051082 (Phosphotyrosine protein) phosphatases II 68-224 8e-25 82.6 In-house 7-148 (151) alignment
Range on Protein: 68-224
Range on HMM: 7-148/151.0
DCAYITDRIIAIGYPATgieanfrnskvqtqQFLTRRHGKGNVKVFNLRGGY--YYDADNFDG---NVICFDMTDHHPPSLELMAPFCREAKEWLEADDK
.. |.|..... |.|                .||   .  |   ..|||. .  .|... .     .|... ..|...|.|.|. ....|. |.|.....
nfsyvtgglyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVIAVHCKAGKGRTGVMICALLIYINfyPSPRQILDYYSIIRTknnkGVTIPSQRRYIYYYH
....|||.|||||||......|.. .   |. ..|..| ..|.    ||..|.| .......
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfa

0040439 (Phosphotyrosine protein) phosphatases II 67-224 3.8e-24 81.1 In-house 47-242 (249) alignment
Range on Protein: 67-224
Range on HMM: 47-242/249.0
LDCAYITDRIIAIGYPATGIEANFRNSKVQTQ-----------------------------------QFLTRRHgKGNVKVFNLRGGYYYDADNFDGNVI
.|. ||..|.|| ..| ..  ..|..   . .                                   ..|   . |....|..|.  ..|| . .  ..|
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhi

CF-DMTDHHPP-SLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLI-----YINFYPsprqILDYYSIIRTKNNKGVTIPSQRRYIYYY
.. |. ||. | |.| .  |.......||.. ......|||.||.||||..|.|.|.     . . ..    ...... .|.. ...|. |.| |..|..
qytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd....leeavkllrsqRpgavqnpeqyrflyea

H
 
l

0045098 (Phosphotyrosine protein) phosphatases II 64-225 2.9e-22 74.8 In-house 4-269 (278) alignment
Range on Protein: 64-225
Range on HMM: 4-269/278.0
NIDLDCAYITDRIIAIGYPATGIEANFRNSKV--------------------------------------------------------------------
. .||. ........ |.| .  .|......                                                                     
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------QTQQFltrrhGKGNVKVFNLRGGYYYDAD--NFDGNVICF-DMTDHHPPSLE---LMAPFCREAKEWLE--------
                       .....     ..  . .....  .....|  ..  .....  . ||..|||.    .  .... .|.|.        
ekcaqywpeggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

----ADDKHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYSIIRTKNNK-GVTIPSQRRYIYYYHK
     |......|||.||.||||....| |.. .. ..   .|.... .|.. .   |....| |..|... 
slllldsggpvlVHCsaGvgRtGtlvaaylmlell.eggvdlleavkelrsqRpglavqnleqyrflyefll

0045450 (Phosphotyrosine protein) phosphatases II 68-223 3.8e-22 74.8 In-house 106-299 (307) alignment
Range on Protein: 68-223
Range on HMM: 106-299/307.0
DCAYI----------------------------------TDRIIAIGYPATGIEANFRNSKVQTQQFLTrrhgKGNVKVFNLRGGYY-YDADNFDGNVIC
. ..|                                  .....|  .| .| | ...| .| .  . .    .....|..|.  .. ..   .  ....
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh....ldgytvrtlevtdldgtgesrtvthfh

F-DMTDHHPP-SLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIYINFY-------PSPRQILDYYSIIRtknNKGVTIPSQRRYIYY
. .  ||. | |.| .  |..|....||.. ......|||.||.||||..|.|.|.. ..        ..........   |    ..|. |.| |..|.
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflye

Y
.
a

0044763 (Phosphotyrosine protein) phosphatases II 57-227 7.6e-22 73.2 In-house 11-170 (178) alignment
Range on Protein: 57-227
Range on HMM: 11-170/178.0
RCRTEYQNIDLDCAYITDRIIAIGYPAtgieanfrnskVQTQQFLTRRHGKgnvKVFNLRGG--------YYYDADNFDGNVICFDMTDHHPPS-LELMA
  . .     ... .|...... ..|.           ..  ..| . . .    . ||..         . |. .... ..... . ||..|. || . 
nleglersdyinaseilpglylgslpp...........addlellkelgit...hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehfl

PFCREAKEWLEaDDKHVIAVHCKAGKGRTGVMICALLIYINfypsPRQILDYYSIIRTKNNkGVTIPSQRRYIYYYHKLR
 |..  .|.|. .......|||.||.||.|....| |.. .       . . .. .| . . .|. |.|.|..|....  
efvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....glsleeaielvrerRp.ivpnpgqlrqLyefelrl

0048179 (Phosphotyrosine protein) phosphatases II 90-225 9.6e-22 72.7 In-house 12-142 (144) alignment
Range on Protein: 90-225
Range on HMM: 12-142/144.0
FRNSKVQTQQFLTRRHgKGNVKVFNLRGGYYYDADNFDG-NVICFDMTDHHPPSL-ELMAPFCREAKEWLEadDKHVIAVHCKAGKGRTGVMICALLIYI
...|   .... . ..  |   |.||. .|...   . | ....... ||..|.| ||.  |..  .|.||  ......|||.||.||||....| |.. 
ylgslptaldlellkk.lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkk

NFyPSprqILDYYSIIRTKNNKGVTIPSQRRYIYYYHK
.   |   . . .  .|...  .|. |.|.|....|.|
lg.ls...leealalvrsrrpgavpnpgqlrfLleyek

0048076 (Phosphotyrosine protein) phosphatases II 107-225 1.8e-20 68.5 In-house 28-140 (145) alignment
Range on Protein: 107-225
Range on HMM: 28-140/145.0
KGNVKVFNLRGGYYYDAdNFDGNVICFDMTDHHPPSL-ELMAPFCREAKEWLEADdkHVIAVHCKAGKGRTGVMICALLIYINFyPSPRQILDYYsiiRT
 |   |.||    ..   ... ....... ||..|.| ||.  |..  .|.|...  ....|||.||.||||....| |.. .   |. ..|...   |.
lgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllg.vsleealelv...rs

KNNKGVTIPSQRRYIYYYHK
.  ..|. |.|.|..|....
qrpgavpnpgqlrflyefel

0046845 (Phosphotyrosine protein) phosphatases II 66-223 1.7e-18 62.5 In-house 69-269 (284) alignment
Range on Protein: 66-223
Range on HMM: 69-269/284.0
DLDCAYITDRIIAIGYPATG-----------------------------IEANFRNSKVQTQQF-------LTRRHgKGNVKVFNLRGGYYY-DADNFDG
|||  ||. ..||  .|  .                               | ..... .....       | . . |....|..|.  ..  .   .  
dldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtv

NVIC-FDMTDHHPP-SLELMAPFCREAKEWLEA-DDKHVIAVHCKAGKGRTGVMICALLIYINFYPS----PRQILDYYSIIRTKNNKGVTIPSQRRYIY
.... ..  ||. | |.| .  |.|...|.||. .....|.|||.||.||||..|.. |..  .          .|.... .|.. .  |. ..| |..|
thfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvy

YY
..
ea

0051299 (Phosphotyrosine protein) phosphatases II 107-222 2.2e-18 62.1 In-house 159-280 (288) alignment
Range on Protein: 107-222
Range on HMM: 159-280/288.0
KGNVKVFNLRGGYY--YDADNFDGNVICFDMT---DHHPPS-LELMAPFCREAKEWLEaDDKHVIAVHCKAGKGRTGVMICALLIYINF-YPSPRQILDY
.....|..|.  ..  .| |..  .|. | .|   ||. |. .||.  |.|.....|. .......|||.||.||||..|...|..  . .     .|..
lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvlea

YSIIRTKNNKGVTIPSQRRYIYY
.  .|.. .  |. |.| |..|.
vkrlreqRpgmvqtpeqyrfvye

0047943 (Phosphotyrosine protein) phosphatases II 130-223 2.9e-18 61.8 In-house 171-267 (273) alignment
Range on Protein: 130-223
Range on HMM: 171-267/273.0
VICFDMTDHHPP-SLELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIY----INFYPSprqILDYYSIIRTKNNKGVTIPSQRRYIYYY
. ...  ||. | ||| .  |.......|||. ......|||.||.||||..|...|..     .  ..   .|...  .|..   .|. |.|.|..|..
fhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd...vleavkllrsqRpgmvqtpeqyrflyea





0036941 (Phosphotyrosine protein) phosphatases II 132-226 1.8e-15 52.5 In-house 175-275 (297) alignment
Range on Protein: 132-226
Range on HMM: 175-275/297.0
CFDMTDHHPPS-LELMAPFCREAKEWLEAD-DKHVIAVHCKAGKGRTGVMICALLIYINF----YPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHK
...  ||..|.  . .  |.......|..  ..... |||.||.||.|..|.| |..  .    .     ||...  .|.. .  |. ..| |..|..  
ytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeall

L
 
e

0050432 (Phosphotyrosine protein) phosphatases II 134-223 3.8e-14 48.2 In-house 206-294 (308) alignment
Range on Protein: 134-223
Range on HMM: 206-294/308.0
DMTDHHPPS-LELMAPFCREAKEWLeadDKHVIAVHCKAGKGRTGVMICALLIYINF-YPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYY
.  ||. |. .| .  |.......|   ....|.|||.|| ||||..|...|..  . .     .....  .|.. .  |. |.| ...|..
nWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra

PTPc_DSPc_SM00012 132-224 2.1e-13 45.7 In-house 7-103 (105) alignment
Range on Protein: 132-224
Range on HMM: 7-103/105.0
CFDMTDHHPP-SLELMAPFCREAKEWLEADD-KHVIAVHCKAGKGRTGVMICALLIYINFYPSP--RQILDYYSIIRTKNNKGVTIPSQRRYIYYYH
. ...||. | . . .  ..|. |.. .. . .. . |||.|| ||||..... ... ... .    .|... . .|.. .. |.   |  ..| ..
ytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral

0051429 (Phosphotyrosine protein) phosphatases II 112-225 4.2e-12 41.8 In-house 49-222 (272) alignment
Range on Protein: 112-225
Range on HMM: 49-222/272.0
VFNLRGGYYYDADN-----FDGNVICFDMTDHHPPSLELMA------------------------------------------------PFCREAKEWLE
...||. .......      . ....... |...|. ...|                                                  ..|. |.| 
ivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellelll

AddKHVIAVHCKAGKGRTGVMICALLIYINFY---------PSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHK
.  .. . |||.|||.|||.....||.. ..           .   ...... .| .  . |  . |....| . .
d..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall

subfamily_PTPDC1_pd Subfamily PTPDC1 89-211 4.8e-12 40.7 In-house 41-159 (182) alignment
Range on Protein: 89-211
Range on HMM: 41-159/182.0
NFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVIC---FDMTDHHPPSLELMAPFCREAKEWLEADdkhVIAVHCKAGKGRTGVMICALLI
.| .|....   | ..    .    . ..|. || ...  . |    | ..|.  .||| .    . ..  |. .    .|||| ||.|||||.|.. |.
kfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylv

YINFYPSPRQIldyySIIRTKNNKGV
| . . . . |    ...| |  | .
yakrltaekai....klvrskrpksi

0048567 (Phosphotyrosine protein) phosphatases II 135-205 2.5e-09 31.7 In-house 44-119 (157) alignment
Range on Protein: 135-205
Range on HMM: 44-119/157.0
M-TDHHPPSLELMAPFCREAKEWLE--ADDKHVIAVHCKAGK---GRTGVMICALLIYINFYpSPRQILDYYSIIRT
.  |. |..| .   |.. ....|.     ...||||||||    |||...|.. ||... . .|........|.| 
fffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf.tpeeaiaplrivrp

subfamily_DSP11_pd Subfamily DSP11 120-198 9.5e-09 29.4 In-house 69-151 (178) alignment
Range on Protein: 120-198
Range on HMM: 69-151/178.0
YYDADNFDGNVICF---DMTDHHPPSLELMAPFCREAKEWLE--ADDKHVIAVHCKAGKGRTGVMICALLIYINFYpSPRQILD
||. ...  . . .    .. |. |. ||.  |... ||.||  .|....|.|||  |  ||| .||  ||  . | .|.. ..
yykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy.epedaie

subfamily_RNGTT_pd Subfamily RNGTT 120-186 2e-07 24.9 In-house 67-137 (189) alignment
Range on Protein: 120-186
Range on HMM: 67-137/189.0
YYDADNFDG---NVICFDMTDHHP-PSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIY
|||.....    . . .... .   |. | .. | .  .|. .   ..||.|||. |  ||| .|.. |. 
yYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLve

subfamily_CDC14_pd Subfamily CDC14 120-220 2.2e-07 25.1 In-house 223-316 (328) alignment
Range on Protein: 120-220
Range on HMM: 223-316/328.0
YYDADNFDGNVIC-FD--MTDHHPPSLELMAPFCREAKEWleaddKHVIAVHCKAGKGRTGVMICALLIYiNFYPSPRQILDYYSIIRTknnkGVTIPSQ
 ||| .|  . .   |  . |   || ...  | . |..      .  |||||||| |||| .| . |.. ..  .  ... .  |.|     |. |  |
lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmk.hyrftaaeaiawlricrP....Gsvigpq

RRYI
....
qkfl

subfamily_DSP23_pd Subfamily DSP23 134-186 3.2e-07 25.1 In-house 58-108 (148) alignment
Range on Protein: 134-186
Range on HMM: 58-108/148.0
DMTDHHPPSLELMAPFCREAKEWLEadDKHVIAVHCKAGKGRTGVMICALLIY
 . |.|||.|| .  | |  .|  |   .  ..|||  |.|||| |.   |. 
riddyhppaleqvvefvrvveeaee..kneavsvhcllgrgrtgtmlacylvk

Y_phosphatase Protein-tyrosine phosphatase 138-221 3.3e-07 25.3 Pfam-A 146-230 (235) alignment
Range on Protein: 138-221
Range on HMM: 146-230/235.0
HH-PPSLELMAPFCREAKEWLeADDKHVIAVHCKAGKGRTGVMICALLIYINFYP-SPRQILDYYSIIRTKNNKGVTIPSQRRYIY
|  | | . .  ..|. ...  ..... . |||.|| ||||..... ..  ..   .  ..|.. . .|.. .. |.  .|  ..|
hgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

Y_phosphatase Protein-tyrosine phosphatase 138-221 3.3e-07 25.3 In-house 146-230 (235) alignment
Range on Protein: 138-221
Range on HMM: 146-230/235.0
HH-PPSLELMAPFCREAKEWLeADDKHVIAVHCKAGKGRTGVMICALLIYINFYP-SPRQILDYYSIIRTKNNKGVTIPSQRRYIY
|  | | . .  ..|. ...  ..... . |||.|| ||||..... ..  ..   .  ..|.. . .|.. .. |.  .|  ..|
hgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 146-227 5.2e-07 24.0 In-house 197-277 (318) alignment
Range on Protein: 146-227
Range on HMM: 197-277/318.0
MAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMiCALLIYINFYPSPrQILDYYS---IIRTKNNkgVTIPSQRRYIYYYHKLR
.  . |..... .  ....|.||| || |||||  .|. | ..      ...| .     .|.. |  . .  . .|.. |. | 
lldlvrqvskaqqksgagpivvhCsaGvGrtGvf.iavdillerikae.alvDvfqtvkqlreqrn..lmvqtedqyefiydvll

subfamily_PTPRK_pd Subfamily PTPRK 144-225 9.8e-07 22.9 In-house 193-272 (314) alignment
Range on Protein: 144-225
Range on HMM: 193-272/314.0
ELMAPFCREAKEWLEAdDKHVIAVHCKAGKGRTGVMiCALLIYINFYPSpRQILDYYSIIRTK-NNKGVTIPSQRRYIYYYHK
. .  . |. |.. |  ..  | ||| || ||||.  .|. | ..     ....| . ...|  ..|   .  . .|.. |  
tgllklvrrvkksqee.eaGrivvhCsaGaGrtGtf.iaidivldmier.egvvdvfnavktlrsrkvnmveteeqykfiydv

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 138-222 1e-06 23.1 In-house 191-277 (319) alignment
Range on Protein: 138-222
Range on HMM: 191-277/319.0
HH-PPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMiCALLIYINFYpSPRQILDYY---SIIRTKNNKGVTIPSQRRYIYY
|  | .. ..  . .. ..  |  ..  | ||| || ||||   ..| . ..   .  ..|| .   | .||. |  |  |.| ..||.
hdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtf.ivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiye

subfamily_PRL_pd Subfamily PRL 129-189 1.2e-06 22.7 In-house 57-117 (151) alignment
Range on Protein: 129-189
Range on HMM: 57-117/151.0
NVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINF
.|. . . |  .|. |..  . .  ||  . . |...|||| || ||. |...  ||   .
evldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 149-230 3.8e-06 21.0 In-house 198-277 (315) alignment
Range on Protein: 149-230
Range on HMM: 198-277/315.0
FCREAKEWlEADDKHVIAVHCKAGKGRTGVMICALLIyINFYpSPRQILDYYSIIRT-KNNKGVTIPSQRRYIYYYHKLRERE
. .| |   .  ... . ||| || |||||.| .  . ..     .. .| . .... ....   . .. .| . |  ..|  
likevkad.ngkkefsllvhcsaGvGrtGvvisidev.vaqi.krtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_PTPRB_pd Subfamily PTPRB 137-222 5.1e-06 20.7 In-house 191-277 (293) alignment
Range on Protein: 137-222
Range on HMM: 191-277/293.0
DHH-PPSLELMAPFCREAKEWL-EADDKHVIAVHCKAGKGRTGVMICALLIYINFYPspRQILDYYSIIRT-KNNKGVTIPSQRRYIYY
||  | . . .  |.|. .|.. .. .|. | ||| || ||||. |.   .  .     ....| ..|.   .... . . ....||. 
dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifi

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 148-226 9.8e-06 19.7 In-house 199-275 (315) alignment
Range on Protein: 148-226
Range on HMM: 199-275/315.0
PFCREAKEWLEADDkHVIAVHCKAGKGRTGVMIcALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKL
 . | .| . ...    | |||.||.|||| .| .|   ..     . |  |  | . ..|.   . .  .| . |  |
nlirtvkqhhtnsv.gaivvhcsaGvGrtGtfi.tldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal