Gene egg-3 in Caenorhabditis elegans

Synonym: CELE_F44F4.2, egg-3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily egg
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP051_AA protein Get Run
CeleP051_AA_198-516 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_egg_pd Subfamily egg 196-514 6.4e-147 483.1 In-house 1-269 (307) alignment 
Range on Protein: 196-514
Range on HMM: 1-269/307.0
EPGKFSCHLTEFVQEFNRldRMFVSNELSDEESLQTAFNANYLTKARSKMVPCAEFSRVKLndglgrlddrnELRNGMFSDeheflqeegytakstygtt
|..|....|.|.|||..|  |..|..|..||.||.||...|.|.|||||.|.|...|||||           |||.|...|                   
eaakkakylseivqeler..rlevleesvdeislttaasdnnlekarskrvhckdssrvkl...........elrrGqyld...................

DFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsanrNHCPYYWPRAENESLRF--GSFHITCMKVDSKADPLF
||||||.|||.||||.||.||||||||..|||||||||..|.||||.|...|           ..|.||||.||..||..  ||..|...||||||||||
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes...........erceyywpkaesdslvtvpGslrienlkvdskadplf

TITKLKVqkVGGNlldaefDEELFLEHWQWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGsPITKSLILQSCVFVRLQ
..||||.  |||.      |||.||||||.|.....||..|.|||||.|.||.|..||.|.|.||..|||.||.||....|| ||||||.|...||.||.
rvtklkl..vGgd......deerflehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlr

RRLSVSSVLLYLFIYRVILRW
|||||.|||||||.||..| .
rrlsvesvllylfvyrlvlff
Y_phosphatase Protein-tyrosine phosphatase 238-512 1e-62 207.0 Pfam-A 2-234 (235) alignment 
Range on Protein: 238-512
Range on HMM: 2-234/235.0
LTKARSKMVPCAEFSRVKLndglgrlddrnelrngmfsdeheflqeegytaKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQF
..| |.|........||||                                |.. |..|.|.|||||| .  ..||..|.|||.| |||||||.|||...
kkknRykdilpydktrvkl................................kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkv

IVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLRFGSFHITCMkVDSK-ADPLFTITKLKVQKVGGNLLDAEFdEELFLEHWQwDWQYLGDVHWPFR
||||.| ...         .|..|..|||..|.|||..|....... ...| ..  .|..||...| ...    |. ..| ...|. |..   ...  ..
ivmltsleek.........grekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslld

VLRKARQLS----TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPitkSLILQSCVFVRLQRRLSVSSVLLYLFIYRVIL
..|| .. .    .|..|.|..|....||.|.....|... ...      .|| .  .| ||. .|.|.  | |.|..||
lirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 238-512 1e-62 207.0 In-house 2-234 (235) alignment 
Range on Protein: 238-512
Range on HMM: 2-234/235.0
LTKARSKMVPCAEFSRVKLndglgrlddrnelrngmfsdeheflqeegytaKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQF
..| |.|........||||                                |.. |..|.|.|||||| .  ..||..|.|||.| |||||||.|||...
kkknRykdilpydktrvkl................................kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkv

IVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLRFGSFHITCMkVDSK-ADPLFTITKLKVQKVGGNLLDAEFdEELFLEHWQwDWQYLGDVHWPFR
||||.| ...         .|..|..|||..|.|||..|....... ...| ..  .|..||...| ...    |. ..| ...|. |..   ...  ..
ivmltsleek.........grekcaqYwpeeeeesltygdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslld

VLRKARQLS----TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPitkSLILQSCVFVRLQRRLSVSSVLLYLFIYRVIL
..|| .. .    .|..|.|..|....||.|.....|... ...      .|| .  .| ||. .|.|.  | |.|..||
lirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
DSPc_SM00195 207-515 4.1e-56 185.6 In-house 2-262 (263) alignment 
Range on Protein: 207-515
Range on HMM: 2-262/263.0
FVQEFNRLDRMFVSNelsdeESLQTAFNANYlTKARSKMVPCAEFSRVKLNDGLGRlddrnelrngmfsdeheflqeegytakstyGTTDFIHANYVKGG
. .||..|...  ..     |. ......|  .| |.|.... . .||||..  ..                               ..|.|.|||.|| 
lkeefekleestspk.....etteaekkknk.sknRyknilpydhtrVklkkeekk..............................egsdYINAnyikga

PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLRFGSFHITCMKVDSKAdPLFTITKLKVQKVGGn
   ...|..|.||..| |||||||..||.. ||||.. ...         ....|  |||. .... .||........|..|    .....|...| |  
nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen.........gkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegk.

lldaefDEELFLEHWQW-DWQYLGDV---HWPFRVLRKARQL----STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPitkSLILQSCVFVRLQRRLSV
      .|. .....|. .|.  |     .  ...||....     |.|..|.| .|....||.|.|...| .. ...      | . .  .| ||  .|
......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmv

SSVLLYLFIYRVILRWI
..   |||||..||..|
qtleqYlfiyeaileyi
PTPc_SM00194 207-515 4.1e-56 185.6 In-house 2-262 (263) alignment 
Range on Protein: 207-515
Range on HMM: 2-262/263.0
FVQEFNRLDRMFVSNelsdeESLQTAFNANYlTKARSKMVPCAEFSRVKLNDGLGRlddrnelrngmfsdeheflqeegytakstyGTTDFIHANYVKGG
. .||..|...  ..     |. ......|  .| |.|.... . .||||..  ..                               ..|.|.|||.|| 
lkeefekleestspk.....etteaekkknk.sknRyknilpydhtrVklkkeekk..............................egsdYINAnyikga

PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLRFGSFHITCMKVDSKAdPLFTITKLKVQKVGGn
   ...|..|.||..| |||||||..||.. ||||.. ...         ....|  |||. .... .||........|..|    .....|...| |  
nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeen.........gkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegk.

lldaefDEELFLEHWQW-DWQYLGDV---HWPFRVLRKARQL----STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPitkSLILQSCVFVRLQRRLSV
      .|. .....|. .|.  |     .  ...||....     |.|..|.| .|....||.|.|...| .. ...      | . .  .| ||  .|
......eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmv

SSVLLYLFIYRVILRWI
..   |||||..||..|
qtleqYlfiyeaileyi
0050432 (Phosphotyrosine protein) phosphatases II 203-518 3e-54 179.8 In-house 40-302 (308) alignment 
Range on Protein: 203-518
Range on HMM: 40-302/308.0
HLTEFVQEFNRLDRMFVsnelsdEESLQTAFNANYLTKARSKMVPCAEFSRVKLNDGlgrlddrnelrngmfsdeheflqeegytakstygtTDFIHANY
 |. . .||..| ....       ..  .|   .  .| |.| ... . |||||..|                                   .|.|.|.|
dlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkldeg...................................sdYInAsy

VKGG--PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAEN-ESLRFGSFHITCMKVDSkaDPLFTITKLK
|.|    | ..||..|.||.|| |||||||...... ||||.. |.          .|. |. |||  .. .||..| |..|......  .. .|...|.
vdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve.........ngrekcaqYwplelgggsleygkftvtllseev..lddytvrtle

VQKVGgnlldaeFDEELFLEHWQW----DWQYLGDVHWPFRVLRKARQL--STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQ
....|        .|.... |...    | .   ..   .. |...|.   . |..| | .|....||.. ....| .. ..  ..   ...   ..| |
ltnlg.......dgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd...vfeavkklReq

RRLSVSSVLLYLFIYRVILRWIEPY
|  .| ..  |||.||..| ... .
Rpgmvqtpeqylflyralleylklk
0036941 (Phosphotyrosine protein) phosphatases II 207-520 2.9e-53 176.5 In-house 15-282 (297) alignment 
Range on Protein: 207-520
Range on HMM: 15-282/297.0
FVQEFNRLDRMFVsnelsdEESLQTAFNANYLTKARSKMVPCAEFSRVKLNDGLgrlddrnelrngmfsdeheflqeegytakstygtTDFIHANYVKGG
. .|| .|.....        || .| . ..|.| |.| ... ...||||.|.                                   .|.|.|.||.| 
llkefeellplll......lgslsvallpenleknRykdilpydhtRVklddeg..................................sdYinAsyvdgy

PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADPLFTITKLKVQKVggn
 | ..||..|.||.|| |||||||...... ||||.. |.          .|. |. |||  |.||| .| |..|...|... .. .|...|.|...   
dlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve.........lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt...

lldaEFDEELFLEHWQWD-WQYL---GDVHWPFRVLRKARQ------LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQSCVFVRLQRRL
    . .|.... |...  |       ..   .. ....|.       ..|..| | .|...|||.. ....|. . ..    .  ||.   ..| ||  
....gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg

SVSSVLLYLFIYRVILRWIEPYVN
.| ..  |.|.|...| ..  . .
avqtleqyrflyeallellkkklt
0040438 (Phosphotyrosine protein) phosphatases II 194-520 4.9e-52 172.5 In-house 8-281 (317) alignment 
Range on Protein: 194-520
Range on HMM: 8-281/317.0
LVEPGKFSCHlTEFVQEFNRLDRMfvsnelsDEESLQTAFNANYLTKARSKMVPCAEFSRVKLNDglgrlddrnelrngmfsdeheflqeegytaKSTYG
...  ..| . | . .||..|...       . .. ..|   .   | |.. ... ..|||||..                               . . 
alldllksdf.talleefedllsl.......kldtysvaelpenkdknrypdilpydhsRVkLsp..............................lggdl

TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRaeNESLRFGSFHITCMKVDSkaDPLF
 .|.|.|.||.|  | ..||..|.||.|| |||||||...... ||||.. ..          .|. |  |||   .|.| .| |..|.....   .. .
dsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtelee.........lgrekcaqYwpl..getltygdftvtllseee..lagi

TITKLKVQKVGGNlldaefdEELFLEHWQWDWQY----LGDVHWPFRVLRKARQL----STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQ
|...|.|.. |..       |.... |... .        .    .. |...|.     ..|..| | .|....||.. ....|... ..  ..   . .
tlrtlevedlgds.......esrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd...vee

SCVFVRLQRRLSVSSVLLYLFIYRVILRWIEPYVN
   ..| ||. .| .   | |.|...| ..  ...
avkelreqRpgavqtpeqyrflydalleylkrklt
0046845 (Phosphotyrosine protein) phosphatases II 207-518 3.3e-51 169.7 In-house 2-277 (284) alignment 
Range on Protein: 207-518
Range on HMM: 2-277/284.0
FVQEFNRLDRMFVSNElsdeESLQTAFNANYLTKARSKMVPCAEFSRVKLNDGLGRLDDRNelrngmfsdeheflqeegytakstygttdFIHANYVKGG
. .|| .| ...|. .     || .|   ..|.| |.| ... . |||||.   |.|.| .                             .|.|.||.| 
leeefeellsltvkll....lslsvallpenlsknRykdilpydhsRVklksldgdledsd.............................YinAsyvdgy

-----PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAeNESLRFGSFHITCMKVDSkaDPLFTITKLKVQ
        ..||..|.||.|| |||||||...... ||||.. |.          .|. |..|||   .|.|..| |..|.....   .. .|...|...
dldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelve.........ngrekcaqYwple.gevltygdftvtllseev..kddytvrtlelt

KVGGnlldaeFDEELFLEHWQW----DWQYLGDVHWPFRVLRKARQL------STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQSCVFVR
..|        .|.... |...    | .   .. . .. ||..|.|      . |..| | .|....||.. ....| ....... ..  .|.   ..|
nlgy......tgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlr

LQRRLSVSSVLLYLFIYRVILRWIEPY
 ||  .| ..  |.|.|...| ..  .
eqRpgmvqtleqyrfvyealleylklk
0051299 (Phosphotyrosine protein) phosphatases II 204-515 3.6e-51 169.7 In-house 22-286 (288) alignment 
Range on Protein: 204-515
Range on HMM: 22-286/288.0
LTEFVQEFNRLDRMFVSnelsdeESLQTAFNANYLTKARSKMVPCAEFSRVKLNdglgrlddrnelrngmfsdeheflqeegytAKSTYGTTDFIHANYV
|| . .||..| .....       .| .|   ..|.| |.. ... . |||||.                                . ....|.|.|.|.
ltglleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLs..............................vldgvegsdYinAsyi

KGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRaeNESLRFGSFHITCMKVDSkaDPLFTITKLKVQKV
.| .| ..||..|.||.|| |||||||...... ||||.. |.          .|. |..|||   ..|| .| ...|......  .. .|...|.|...
dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklve.........lgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnl

GGNLldaEFDEELFLEHWQW----DWQYLGDVHWPFRVLRKARQL----STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQRR
.        .|...  |...    | ..  ..   .. ||..|.     . |..| | .|....||.. ....|... ..  ..   .|.   ..| || 
dlld...gdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd...vleavkrlreqRp

LSVSSVLLYLFIYRVILRWI
 .| ..  |.|.|...| ..
gmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 205-515 6e-50 165.6 In-house 12-272 (273) alignment 
Range on Protein: 205-515
Range on HMM: 12-272/273.0
TEFVQEFNRLDRMFVsnelsdEESLQTAFNANYLTKARSKMVPCAEFSRVKLndglgR---LDdrnelrngmfsdeheflqeegytakstygttdFIHAN
| . .||..| ....      . . ..|   ....| |.| ... . |||||          |                                .|.|.
tllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl.....gdggsd................................yinAs

YVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENE-SLRFGSFHITCMKVDSkaDPLFTITKLKV
||.| .| ..||..|.||.|| |||||||...... ||||.. |.          .|. |..|||  ..| ||..| |..|......  .. .|...|..
yvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelve.........lgrekcaqYwpleggelsltygkftvtllseet..kddytvrtlel

QKVGgnlldaeFDEELFLEHWQWD-WQylgDVHWP------FRVLRKARQ------LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSC
...|       ..|...  |...  |    | . |      .. ....|.       ..|..| | .|....||.. ....| .....  ..   .|.  
tnlg.......tgesrtvthfhytgwp...dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd...vleav

VFVRLQRRLSVSSVLLYLFIYRVILRWI
 ..| ||  .| ..  |.|.|...| ..
kllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 204-515 4.2e-46 153.5 In-house 26-304 (307) alignment 
Range on Protein: 204-515
Range on HMM: 26-304/307.0
LTEFVQEFNRLDRMFVSNelsdEESLQTAFNANYLTKARSKMVPCAEFSRVKLNDGLgrlddrnelrngmfsdeheflqeegytakSTYGTTDFIHANYV
|| . .||..| .. |        .  .|   .  .| |.| ... . .||||..                               ......|.|.|.||
ltgllkefekllsvtvfl....lgeysiallpenkdknrykdilpydhtRVklssld.............................gsledsdYiNAsyv

--------KGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAeNESLRFGSFHITCMKVDSkaDPLFTI
        .|  | ..||..|.||..| ||||||....... ||||.. |.          .|. |. |||   .|.| .| |..|.....   .. .|.
rvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve.........lgrekcaqywPde.geeltygnftvtllseeh..ldgytv

TKLKVQKVggnlldAEFDEELFLEHWQW----DWQYLGDVHWPFRVLRKARQ------LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPI---Tksl
..|.|.         . .|.... |...    | .   ..   .. ....|.       ..|..| | .|.. .||.. . ..| .. ..  .   .   
rtlevtdl......dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd...

ILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWI
.|.   ..| ||  .| .   | |.|...| ..
lleavkllreqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 206-515 1.7e-45 151.0 In-house 21-277 (278) alignment 
Range on Protein: 206-515
Range on HMM: 21-277/278.0
EFVQEFNRLDRMFVsnelsdeESLQTAFNANYLTKARSKMVPCAEFSRVKLNDglgrlddrnelrngmfsdeheflqeegytaKSTYGTTDFIHANYVKG
 . .|| .|.....       ..  .|   .  .| |.| ... ..|||||..                               .    .|.|.|.||.|
llllefeellsfkl.......dtysiallpenkdknrykdilpydhsrvklsl..............................lggdldsdYinAsyvdg

GPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPraeNESLRFGSFHITCMKVDSkaDPLFTITKLKVQKvgg
 .  ..||..|.||..| |||||||...... ||||.. |.          .|. | .|||   ..||..| |..|..|...  .. .|...|.| .   
ynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelve.........lgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtn...

nlldAEFDEELFLEHWQW-DWQylgDVHWP------FRVLRKARQ----LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQR
       .|...  |... .|    | ..|      .. |...|.     ..|..| | .|....||.. ....|... ..  ..   ...   ..| ||
....lgdgesrtvthyhylgwp...dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd...leeavkelreqR

RLSVSSVLLYLFIYRVILRWI
  .| .   | |.|...| ..
pgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 204-517 1.1e-44 148.4 In-house 31-291 (297) alignment 
Range on Protein: 204-517
Range on HMM: 31-291/297.0
LTEFVQEFNRLDRMFVsnelsdEesLQTAFNANYLTKARSKMVPCAEFSRVKLNDGLgrlddrnelrngmfsdeheflqeegytakSTYGTTDFIHANYV
 | . .|| .| ....      .    .|   .  .| |.| ... ..|||||..                               ...  .|.|.|.||
ktllllefeellslkp......d..ysiallpenkdknrykdilpydhsrvklkped.............................gvdldsdYinAsyv

KGGPL-LNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRnHCPYYWPRAENeslRFGSFHITCMKVDSkaDPLFTITKLKVQK
.|  |  ..||..|.||..| |||||||...... ||||.. |. .         | .|. |||  ..   ..| |..|..||.   .. .|...|.|..
dgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelg.........r.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn

vGGnlldaefdEELFLEHWQW----DWQYLGDVHWPFRVLRKARQ------LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRL
 .|        |.... |.|.    | .   ..   ...|...|.       ..|..| | .|....||.. . ..| .. ..  ..   .|.   ..| 
.ng........esrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd...vleavkelre

QRRLSVSSVLLYLFIYRVILRWIEP
||. .| .   | |.|...| ..  
qRpgavqtpsqyrflydallellkr
0045098 (Phosphotyrosine protein) phosphatases II 236-516 3.4e-43 143.4 In-house 32-273 (278) alignment 
Range on Protein: 236-516
Range on HMM: 32-273/278.0
NYLTKARSKMVPCAEFSRVKlndglgrlddrnelrngmfsdeheflqeegytakstygttDFIHANYVKGGPllNTFICAQAPLKNTQEDFWRMVFQEKC
. | | | | ... ..||||                                        |.|.|.|..| |  ..||..|.||..| .|||||......
gnldknRykdilpydhsrVk........................................dYINAsyidgyp..kkfIatqgPlpstvadfwrmlwelgi

QFIVMLNSAVDSStlgpldsanRNHCPYYWPRaeNESLRFGSFHITCMKVDSKadPLFTITKLKVQKVGGNLldaEFDEELFLEHWQW-DWQYLGDVHWP
. ||||.. |. .         |..|. |||   ..||..| |..|.....    . .|...|.|. .  .    | .|.....|...  |   |  . |
tvivmltelvelg.........rekcaqywpe..ggsltygdftvtllseevl..ddytlrtllvtnltver...edlesrgvthlhylpwpdhgvpslp

--------FRVLRKARQ--------------LSTPTIVQCIDGCSKSGTLVSIETALMHFirGSPITkslILQSCVFVRLQRRL-SVSSVLLYLFIYRVI
        .. .|.|..               ..|..| |  |.. .|||| . . | ..  .. ..   .|.   ..| ||.  .| .   | |.|...
ilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvd...lleavkelrsqRpglavqnleqyrflyefl

LRWIE
|....
lelll
0040439 (Phosphotyrosine protein) phosphatases II 236-515 7.4e-42 139.0 In-house 10-246 (249) alignment 
Range on Protein: 236-515
Range on HMM: 10-246/249.0
NYLTKARSKMVPCAEFSRVKLNDglgrlddrnelrngmfsdeheflqeegytaKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKC
. . | |.. ... ..|||||..                               . .  .|.|.|.|..|    ..||..|.||..| ||||||......
enkdknrypdilpydhsrvklsi..............................lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgi

QFIVMLNSAVDSstlgpldsaNRNHCPYYWPRaeNESLRFGSFHITCMKVDSKADplFTITKLKVQKVggnlldaEFDEELFLEHWQW-DWQYLG---DV
. ||||.| |           .|..|  |||   ..|| .| |..|...|..|.|  .|...|.....       ...|..   |.|. ||   |   ..
tvivmLtslvel.........grekcaqywpl..ggsleygdftvtllsvevkdd..ytvrtleltnl.......ydgesrtvlhiqytdwpdhgvppsf

HWPFRVLRKARQ------LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWI
   .. ....|.       ..|..| | .|....||.. . ..|... .   ..   ...   ..| ||. .| .   | |.|...|...
edlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd...leeavkllrsqRpgavqnpeqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 238-515 7.1e-40 132.3 In-house 10-243 (245) alignment 
Range on Protein: 238-515
Range on HMM: 10-243/245.0
LTKARSKMVPCAEFSRVKLNDglgrlddrnelrngmfsdeheflqeegytaKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQF
 .| |.. ... ...||||..                               ..   .|.|.|.||.|    ..||..|.||..| ||||||....... 
kdknrysdilpydhtrvklsp..............................dggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgitt

IVMLNSAVDsstlgpldsANRNHCPYYWPRaeNESLRFGSFHITCMKVDSkaDPLFTITKLKVQKVggnlLDAEFDEELFLEHWQWDWQYLGD-VHWPFR
||||.. ..          .|. |. |||   .|||..| |..|......  .. .|...|.|...     | |  | . . .  |. .   | . . ..
ivmLteeee.........lgrvkcaqywpl..gesltygdftvtllseeh..lddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllellld

VLRKARQ-----LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWI
.|. .|.      ..|..| | .|.. .||.. . ..|... .   ..   . .   ..| ||. .| .   | |.|...| ..
flefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs...leeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 236-514 1.8e-33 111.5 In-house 9-241 (243) alignment 
Range on Protein: 236-514
Range on HMM: 9-241/243.0
NYLTKARSKMVPCAEFSRVKLndglgrlddrnelrngmfsdeheflqeegytakstYGtTDFIHANYVKGGPllnTFICAQAPLKNTQED----FWRMVF
. |.| | . ... ..|||||                                    | .|.|.||.... |   ..|. |.||..| ||    ||||..
enlsknrysdilpydhsrvkl...................................eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlw

QEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPraenESLRFGSFHITCMKVDSKADplFTITKLKVQKVG-GNLLdaefdeELFLEHWQWDWQY---
..... ||||.. |.          .|. |. |||    .. ..| |..|.... ...|  .|...|... .. ..|        |   .... |     
elgitvivmltelvEl.........grekcaqywp....gevtygdftvtllseehldd..ytvrtlllenldlddlt......rlvihyhylpwpdhgv

---LGDVHWPFRVLRK---------ARQLSTPTIVQCIDGCSKSGTLVSIETALMHFirgspitKSLILQSCVFVRLQRRL-SVSSVLLYLFIYRVILRW
     |.   .. .|.         |.  . |..| |  |....|||. . . |...       .  ...   ..| ||   .| .   | |.|...| .
PdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Ptp69D_pd Subfamily Ptp69D 293-516 8.2e-29 95.7 In-house 74-287 (307) alignment 
Range on Protein: 293-516
Range on HMM: 74-287/307.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNHCPYYWPRAenESLRFGSFHITCmkVDSKADPL
 ..|.| |...||    ..||.||.|. .| .|||||. . . . ||||           |.  ||..|. |||    .  ..|.  ...  |...  . 
edsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn.........lteknrkkcakYWpie..devqygdilvkl..vseekhsd

FTITKLKVQKVGGNLLDAEFDEELFLEH---WQwDWQYLGDVHWPFRVLRKA----RQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQ
..| .|.| |.. .  . |   ..   |   |. | .     .  .......    ..  .| .| |  | ..||..|...  | .      .    | .
yiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvd...ife

SCVFVRLQRRLSVSSVLLYLFIYRVILRWIE
    .| || | | |   | |.|| .| ...
tvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 294-514 9.1e-29 95.0 In-house 65-268 (281) alignment 
Range on Protein: 294-514
Range on HMM: 65-268/281.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENESLRFGSFHITcmKVDSKADPLF
.||.|||||..   |   .| .| | |.|. |||||..||.   ||||   ..         .||..|  |.||     |.|  . ..    ||  .  .
stdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfle.........tnrekcaeyfprnahcclqfdklsvs..yedstvnksl

TITKLKVQKVGGNLLDAEFdeelFLEHWQwDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFiRgSPITKSLILQSCVFVRLQ
  |.|..   |   | . .    . . |  |||  .     ...||| |  ||| ...|  |  .||||...| ||    . | .|   | |    .|. 
vttrlnlsyegetrlithw....lwkewp.dwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsi.h.shftlpdikqivshlrvt

-RRLSVSSVLLYLFIYRVILRW
 |  || ..  |..|..|.| .
graasvqtlqqymliwkvlldf
subfamily_PTPRD_pd Subfamily PTPRD 294-520 8.7e-28 92.3 In-house 75-286 (564) alignment 
Range on Protein: 294-520
Range on HMM: 75-286/564.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAeNeSLRFGSFHITCMKVDSKADplF
 .|.| |....|    ...| .|.||..| |||||||...... ||||.. ...         ... |  |||   . . ..|....| ..   .||  .
gsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk.........gkvkchkYWPek.g.tetygeltVtleeeeelad..y

TITKLKVQKVGgnlldaeFDEELFLEHWQW-DWQYLGDVHWPFRVLRKA-------RQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQ
.|...|..|          .|    ..... .|   |  . .  .|.         .. . |..|.|  |   .|| . |.  |        .    | |
eirtfklkkkk.......ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvD...iyq

SCVFVRLQRRLSVSSVLLYLFIYRVILRWIEPYVN
    .| ||   | .   | ||...||  .. ...
yvkalrkqRnamVqteeQYiFiheailealacgnt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 264-515 5.9e-27 89.5 In-house 48-279 (288) alignment 
Range on Protein: 264-515
Range on HMM: 48-279/288.0
DDRNELRNGMFSDEHEFLQEEGytakSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPY
...|  || .  ||..   ...     .  ..|.| |.|..|    ...|..|.|| .| .|||..|...| . ||||.. |.          ....|  
akknRyrnilpyDekrvklkkl....eeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveg.........gktkCee

YWPRAENEsLRFGSFHITCMKVDSKADplFTITKLKVQKVGGNLLDAEFDEELFLEHWqwdwqyLGDVHWPF----RVLRKARQL-STPTIVQCIDGCSK
||| |...  ..||. .| ...  . |  |.  || ..| ...|   ...   . .|         . . |.    | .  | |  . | ||.| .|  .
YWPdadkp.knyGsvtvtlveskeled..fvlrklllekkkteleitqyqylaWpdhg......vPeskapllellrqvkvanqadtgpiivhCsaGvGr

SGTLVSIETALMHFIRgspiTKSL-ILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWI
.|| ....... .  .    .. . ..     .| || | |  .  | |||.|.|  |
tgtFialdalidavee....edyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPRB_pd Subfamily PTPRB 293-516 9.7e-27 88.7 In-house 77-286 (293) alignment 
Range on Protein: 293-516
Range on HMM: 77-286/293.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENeSLRFGSFHITCMKVDSKADpl
 ..|.| |||..|    . || .| || .| .||||||...|.. ||||   |.           . .|  |||. |. .  .|. ..| .. ... |  
sgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvek.........gkvkCeeYWPadee.pvlyGdikvtlvaeeeled..

FTITKLKVQKVGGNLLDAEFDEELFLEHWQWDW-QYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVR
..| .||..|   .    ...   . .|   .  . | |    .|   .  . ..|..| |  |  ..||...... | .  .   .    |.   . .|
wvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvd...ifgivaelR

LQRRLSVSSVLLYLFIYRVILRWIE
 .| | | ..  |.||....|. ..
eeRnllvqtekqYifihqcvldllr
subfamily_PTPRG_pd Subfamily PTPRG 293-522 1.8e-26 87.5 In-house 74-294 (563) alignment 
Range on Protein: 293-522
Range on HMM: 74-294/563.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNHCPYYWPRaeNESLRFGSFHITCMKVDSKAdpL
.. |.| |||..|    . || .| |||.| .|||||..... . |||.           |   .|..|. |||.  .||...|....| .. . .|  |
kklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitn.........lvergrrkcdvYWPk..desetygalqvtlieeevla..l

FTITKLKVQKVGGNLLDAeFDEELFLEHWQW-DWQYLGDVHWPFRVLRKARQL-------STPTIVQCIDGCSKSGTLVSIETaLMHFIRGSPITKslIL
 |. .|.....  .  .   |.|.   .... .|   |  . .  ||  ...          |..| |  | ...||.. ..| |.. |.   .    ..
ytvrtlviknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldt.llkqiqqenavn..vf

QSCVFVRLQRRLSVSSVLLYLFIYRVILRWIEPYVNKW
.    .|.||   | .   |.|.. ..| .|    .. 
gflkhiraqRnflvqteEqYiflhdalleaiasketel
subfamily_PTPN12_pd Subfamily PTPN12 292-516 2.2e-26 87.4 In-house 65-278 (290) alignment 
Range on Protein: 292-516
Range on HMM: 65-278/290.0
YGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADP
    |.| ||..||.    ..| ||.|| .| .|||||... . . .||.   |.          ....|  |||   .|.|.||.|..|... .   | 
eegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCreve.........lgkkkCerYWpeegeeelefgefevtleeekavddd

lFTITKLKVQKVGGNLLDAEFDEELFLEHWQ-WDWQYLGDVHWPFRVLRKarQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQSCVFV
 |.|  |||.. . .     |  . . .|      . | .. . .| |..  . ..| .| |  |. . ||...|. . . . ..    .  . .  . .
.flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlel

RLQRRLSVSSVLLYLFIYRVILRWIE
| ||   | .   | ..|. ..  ..
rkqraalvqtkeqyelvykavaelvq
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 293-516 3.6e-26 87.1 In-house 82-291 (298) alignment 
Range on Protein: 293-516
Range on HMM: 82-291/298.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENEslRFGSFHITCMKVDSKADpl
  .|.| | ....    |.|| .||||..| ||||||| .|. . ||||.. ...         .. ... |||  ..|  ..|..... .. ...||  
eesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleel.........dktkyhkywPdegke..tygeitvsllskeefad..

FTITKLKVQKVGGNlldaEFDEELFLEHWQWDWQYLGDVHWPF-----RVLRKARQLS-TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQS
....||||.|   .    .  |   |.. .|  .    ..        .| .. .|   .| |||| .|  .||| . |.. | .  . . .    ..| 
livrklkvskkkee....kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvD...vfqv

CVFVRLQRRLSVSSVLLYLFIYRVILRWIE
   .| .|  .| .   | ||| ..|. ..
vkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN23_pd Subfamily PTPN23 293-521 3.7e-26 86.6 In-house 65-286 (288) alignment 
Range on Protein: 293-521
Range on HMM: 65-286/288.0
GTTDFIHANYVKG-GPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADP
.. |.| | .||.  |   .||..||||..|  |||.||...| . |||| |  .          .....  ||| ...|. .|| ...|. .| .    
skDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskee.........lgkpkvdrYwPedkgetvkfgdlsvtlksvreteth

LFTITKLKVQKVGGNLLDAEFdeelFLEHWQW----D-----WQYLGDVHWPFRVLRkaRQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKsl
   . ||.....              |. |      .      |.|. |.  ..  .  |.. || .|.|  |  ..|..  . .|.  . .|  ..   
vervlkletldadavksvshl....qltsWpelGvPasPetllqfldevesayeavq..rksktPlvvhCsaGvgRtgvfalvyaavrelekgnglld..

ILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWIEPYVNK
|.|    .| ||| .|. .  . | | ..|. .. . .|
iiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvldk
subfamily_PTPN3_pd Subfamily PTPN3 293-514 6.1e-26 86.0 In-house 63-274 (280) alignment 
Range on Protein: 293-514
Range on HMM: 63-274/280.0
GTTDFIHANYVK----GGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRNHCPYYWPRaENESLRFGSFHITCMKVdsK
..||.| ||||.    .  | | .| .| ||..| .|||.||...|...|||| . |..          |  |  |||. ....|..|.|...| |   .
setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG.........rvkChqyWPe.tedeleygefsvkceke..d

ADPLFTITKLKVQKVGGNlldaEFDEELFLEHWQWDWQYLGDVHWPF----RVLRKAR-QLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLI
..  . . .| ...   .    |  . | | . .|  . . | .  |    . .||.|   ..|..| |  |  ..| |. .||||.   .  |.    |
etksyvlrelvlkdketk....eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldi

LQScvfVRLQRRLSVSSVLLYLFIYRVILRW
..    .| ||   | ..  | |.   ||. 
vrt...mrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 293-513 7e-26 85.5 In-house 79-281 (290) alignment 
Range on Protein: 293-513
Range on HMM: 79-281/290.0
GTTDFIHANYVKGgpLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRNHCPYYWPRAENESLRFGSFHITCMKVDSKaDPL
.  |..|||||||  |  .|| .| .||.|  |.|||| |||  .||||   ..           . .|  |.|  | | | ||.. ..| . |.| |  
ydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedG.........kakceqyypekeGevltfGeitvlcseeddk.dan

FTITKLKVQKVGGNlldaEFDEELFLEHWQWDWQYLGDVHW-PFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVR
     | |...              |.   |  . .       .|.||  |..| | .| |  |  ..||.|.||..|  .. |  .    .|. .  .|
iikktlsvrdkdsG....kehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeld...lldlvralr

LQRRLSVSSVLLYLFIYRVILR
  |  ||   . || . ...| 
nsrlnsvqvdiqylalveilld
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 287-515 8.7e-26 85.8 In-house 66-283 (305) alignment 
Range on Protein: 287-515
Range on HMM: 66-283/305.0
TAKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENESLRFGSFHITCMKVD
|.|.. . .|.| |.||.|    ...| ||.||||| .||||....|| . ||||   |.          ... |  ||| ...|. .||.|...     
tekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve.........ggkdkCrqYWpesktekkefgefsvelksek

SKADplFTITKLKVQKVGGnlldaEFDEELFLEHWQWDWQYLGDVHWP------FRVLRKARQLS--TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPI
. .|  ... |||. .  .     . ..   |..   ||   | .. .      .. ..|... .  .| .| | .| ...|. .... || .  .   .
tasd..yieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevv

TKSLILQScvfVRLQRRLSVSSVLLYLFIYRVILRWI
    .|.    .| .|   |..   | |.. ..   |
dvfevlkq...lRskrmkmvqtldqYvflhdaldeli
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 294-516 2.3e-25 84.2 In-house 36-243 (250) alignment 
Range on Protein: 294-516
Range on HMM: 36-243/250.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNhCPYYWPRaeNESLRFGSFHITCMKVDSKADplF
 .|.| | ...|    ..|| .|.||..| |||||||..|| . ||||..         |   ... .. |||   ... ..|. ... .. . .||  .
esdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtn.........Lkesekt.yhqywPv..ekaekyGdvtvsllskeefad..y

TITKLKVQKVGGNllDAEFdeELFLEHWQWDWQYLGDV-----HWPFRVLRKARQ-LSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSC
|..|||. |   .  |        |.. .|  .   .|     .   .| .. .|  ..| ||||  | ..||. . |.. | .  .   .    . .  
tkrklklskakka..deri..vrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvd...vfkvi

VFVRLQRRLSVSSVLLYLFIYRVILRWIE
  .| .|  .| |   | |.|..||. ..
kvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPN6_pd Subfamily PTPN6 294-517 1.8e-24 81.3 In-house 80-299 (306) alignment 
Range on Protein: 294-517
Range on HMM: 80-299/306.0
TTDFIHANYVKG----GPllNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLrFGSFHITCMKVdsKA
 .|.| |||.|.        ...| .|  |..| .||||||.||... |||.   |.          ....|  ||| .|...  .|. ..|...   |.
gsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivmttkevEr.........gkekCarYWPdeeekee.yGkisvtnvse..ks

DPLFTITKLKVQKVGGNLLDAEFDEE--------LFLEHWQWDWQYLGDVHWPFRVLRKArqLSTPTIVQCIDGCSKSGTLVSIETaLMHFIRGSPITKS
   ... .|.|.|.  .    |  .            .. .   ..| ||.   . |..|   . |..| | .|  . ||.. |.. |.. |. . .   
ladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea..eagpivvhCsaGiGRtGtfiviDi.llkliekkgldad

LIL-QSCVFVRLQRRLSVSSVLLYLFIYRVILRWIEP
. . ..   || ||   |     | |.|..|  .|| 
idiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 289-511 3e-24 80.7 In-house 70-284 (325) alignment 
Range on Protein: 289-511
Range on HMM: 70-284/325.0
KSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSaNRNHCPYYWPRAENESLRFGSFHITCMKVDSK
|   . .|.| |.|..     ..|. ||||| .| .|.||.|.. .|  .|.||          ||  . ..|  |||.   .| .||....  . ..  
kkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne.........ldl.gkdrcavywpkemgksktfGglevklrtieei

ADPLFTITKLKVQKVGGNLLDAEFDEELFL-----EHWQWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslI
.| .  . ..|  | |  .   .|.   .      ..      .|  |.     ..   . ||| .| |..|  ..|...|. .|| . |  | .    |
sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvd...i

LQSCVFVRLQRRLSVSSVLLYLFIYRVI
...   .| .|   | .|  | .||  .
fgfvkklrkdrpsmvetvdqyiliyeal
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 294-522 5.3e-24 79.4 In-house 79-297 (305) alignment 
Range on Protein: 294-522
Range on HMM: 79-297/305.0
TTDFIHANYVkGGPLLN--TFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLgpldsanrnHCPYYWPRAENESLRFGSFHITCMKVDSK---
 .|.|||||| | |..    ||||| || .| ..|| || |.| . ||||  .|.   |         .|  ||| |  | | . |  .      ||   
psdyihanyv.gcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgkl.........kcaqywpaaqgeklelksgivvenvsgskpme

ADPLFTITKLKVQKVGGNLLDaefdeelfLEHWQW-DWQYLGD--VH-WPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLIL
 |.   || |..   |.. .         . | || .|   |   ..   . .|   |    | .|.|  |  ..||.|.||  | .     |      |
rdaeiqitllnltysgdqkms........vrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpel

qsCVFVRLQRRLSVSSVLLYLFIYRVILRW-IEPYVNKW
     .| ||  |. . . ||||.||.| . .| | .|.
..vkalrdqrafsiqndvqylfihrvmlnyflekykeky
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 297-524 1.5e-23 78.2 In-house 69-277 (288) alignment 
Range on Protein: 297-524
Range on HMM: 69-277/288.0
FIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstLGPLDSANrnhcpyYWPRAENESLRFGSFHITCMKVDSKADPLFTIT
.|.|| |  ..  . .|||||||. | | .|.|....  ..||||.  ..   .|   ||.      |.|    |. |.| .     |  .  | | ...
yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcelle...kGkeksae......yfPsklGekarigrlctvvkkkradidklvkvs

KLKVQKVGGNLLdaeFDEELFLEhwQWDWQYLGDVH-WPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSpitKSLILQSCVFVRLQRR
 |...|.| .     .   | |   .|| . . . .  |.|.|   ..|  | .|..  |  ..|||. |  ||           . | . .   | .|.
llriskegeekv...ivkilhll..eWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrldd...flgirsllaklreerf

LSVSSVLLYLFIYRVILRWIepyVNKWYH
 .. .   ||...|..|  .   . |.|.
kaiqtemqylyvhrcvleel...llkkyk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 268-516 1.6e-23 78.2 In-house 67-277 (281) alignment 
Range on Protein: 268-516
Range on HMM: 67-277/281.0
ElrngmfsdeheflqeegytakstygTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPr
.                         .||.| ||.|.|    . .| .|.|. .. ..||.||...| . |||.   ..         |.. .|  ||| 
k.........................ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie.........agklkChrYWP.

AENESLRFGSFHITCMKvdSKADPLFTITKLKVQKVGGNLLDAE-FDEELFLEHWQW-DWQYLgdVHWPFRVLRK-ARQLSTPTIVQCIDGCSKSGTLVS
 .|..|..| .... ..  ... . .   |.|... .|.  . | .    . .|    . . |  ...   ||.   ..  .| .. |  |  ..|| ..
ddnselkygdvtvksta..eeekatyierkfkleresgetreveqlaytaWPdhGvPattkel..lefrkevlkltekktkaplvihCsaGvGrtGtyia

IETALMHFIRGSpiTKSLILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWIE
..... .  .    ..  . .    .| .| | | .|. | |.|...|. ..
lDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldald
0041856 (Phosphotyrosine protein) phosphatases II 240-515 2.1e-23 78.2 In-house 4-171 (182) alignment 
Range on Protein: 240-515
Range on HMM: 4-171/182.0
KARSKMVPCAEFSRvklndglgrlddrnelrngmfsdeheflqeegytakstygTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIV
| | . ... ..||                                          |.|.||.. |.   ..||..|.||..| .||.||. ..... ||
knrysdilpydhsr........................................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittiv

MLNsavdsstlgpldsanrnhCPYYWPraeneslrfgsfhitcmkvdskadplftitklkvqkvggnllDAEFDEELFLEHWQWDWQYLGDVHWPFRVLR
.|.                  ...|||                                          . . .. . . ...|.     |..  .. ..
nlt..................eelywp..........................................ellerlgiqylylpwpDhgvpdldelldfie

KARQLSTPTIVQCIDGCSKSGTLVSIEtaLMHFIrgspitKSLILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWI
.... . |..| |  |....|||| .   ||.        .  . .   .|| .|  .| .   | |.....| ..
evleeggpvlVHCsaGvgRtgtlvaay..lmkkl......gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPRK_pd Subfamily PTPRK 294-513 1e-22 75.3 In-house 70-275 (314) alignment 
Range on Protein: 294-513
Range on HMM: 70-275/314.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVdsstlgpldSANRNHCPYYWPraENESLrFGSFHITCMKVDSKADPLF
 .|.| |... .    . || .| ||..| .||||.|..|.|  ||||.  |         .  | .|  |||  |. .  .| ......... .|. . 
ssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelv.........evgrvkClkyWP..edtev.ygdikvelvetellaelvv

TITKLKV--QKVGGNLLDAEFDEELFLEHwQWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETaLMHFIRGSPITKslILQSCVFVR
 | ...   ... .  .  .|.   . .| .   .  | ..   ||  .  .   ...| |  |. ..|| . |.. ..  |.   .    . .    .|
rifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi.vldmieregvvd..vfnavktlr

LQRRLSVSSVLLYLFIYRVILR
 ..   |     | ||| ||| 
srkvnmveteeqykfiydvile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 293-518 1.3e-22 75.3 In-house 72-283 (318) alignment 
Range on Protein: 293-518
Range on HMM: 72-283/318.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRNHCPYYWPraENESLRFGSFHITCMKVDSKADpl
 ..|.| |||. |    ...| ||||| .| |||||||.. ... ||||   ....         .. .  |||  ...|  .|. ... ..  . .|  
egsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeerg.........kakvhryWP..skgsrsygklvvelkeevelsd..

FTITKLKVQKVGGNllDAEFDEELFLEHWQwDWQYLGDVHWPFRVLRKARQLS-----TPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSC
... ..||.. . .  .           |  |   . ..     ..|....       .|..| |  |  . |. . ... | .    . .    ..|  
yvlrefkvtrteee..esrqvrqyhytsWp.degvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD...vfqtv

VFVRLQRRLSVSSVLLYLFIYRVILRWIEPY
  .| || | |     | ||| |.|  .. .
kqlreqrnlmvqtedqyefiydvllealasg
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 294-516 1.3e-22 75.3 In-house 75-284 (319) alignment 
Range on Protein: 294-516
Range on HMM: 75-284/319.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLgpldsanrnHCPYYWPRAENEslRFGSFHITCMKVDSKADplF
 .|.| |... |    . || .||||.|| |||||||..|..  .|||.  |.   .         ..  |||... |  ..| . .|  . . ..|  .
gsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkv.........klkkywpeenfe..eyGrlivtleeeeeled..y

TITKLKVQKVGGNLLDAEFDEELFLEhWQWD--WQYLGDVHWPFRVLRKARQL--STPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVF
 | |||..|  ...   |  .  ..| |  .   ...  .   .. .||.|.   | | .| | .|  . || . .. .| .  . . .    . .    
iirklklnkkssevetRevkhfqyte.WpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlD...vfstvsr

VRLQRRLSVSSVLLYLFIYRVILRWIE
.|.|| . |.    | ||| ..| ..|
lRtqRnimvqrpeqYkfiyealleave
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 294-515 1.4e-22 75.1 In-house 66-277 (307) alignment 
Range on Protein: 294-515
Range on HMM: 66-277/307.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRNHCPYYWPRAENESLRFGSFHITCMKVD------S
..|.|||||.      . ||||| ||.||| .|| |. ||| . ..||  ... .         . .|  |||  | . | ||.   |    .      .
asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviela.........kikceqywpleegqklvfgeapntisvanlgakkla

KADPLFTITKLKVQKVGGNlldaefdeeLFLEHWQWD-WQYLGDVHWP---FRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLI
  . |  .|.|||.  ...           ..|.||. |   |  .       .|   |    | .| |  |  .|||.|.|       |.|    .   
pdedlinvttlkvdwaqks.........rtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkk

LqsCVFVRLQRRLSVSSVLLYLFIYRVILRWI
|     .| ||. .. . . ||...||.| . 
l..veelrsqrhyaiqteaqylylhrvlleyf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 294-516 1.7e-22 74.7 In-house 47-265 (270) alignment 
Range on Protein: 294-516
Range on HMM: 47-265/270.0
TTDFIHANYVKGGP-LLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNsavdsstlgPLDSANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADPL
.| .| ||||.|     ...|.|..||..| ..||||...|| . |||.          .|   .|..|  |||   .|....   .|. ... .. .  
ataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmtt.........gleEkgrkkCerYWpaepkekvkledgkikvlalseekeeg

FTITKLKVQKVGGNLLDAEFDEELFLEHWQ---WD-WQYLGDVHWPFRVL---RKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQ
. .|.|.... | .     |  . . .|      |   .  ..   .| .   .|  . ..|..| | .|  ..|||. ...|.    . . .    |..
yiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiie

ScvfVRLQRRLSVSSVLLYLFIYRVILRWIE
    .| .|   |. .  | |.|.... ..|
e...lRkdRmalvqhpeqyeflykavveyae
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 294-516 2.4e-22 74.1 In-house 75-284 (290) alignment 
Range on Protein: 294-516
Range on HMM: 75-284/290.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESlrFGSFHITCMKvDSKADpLF
| ..|.| |.||    . .| .|.|..||  |||... |||.  |||| . ...         ....|  ||| .....  .| |.|. .. ... .  .
tneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniiee.........gkvkCqqYWpdsdtka..ygefsiklln.eetln.ey

TITKLKVQKVGGNlLDAEFDEELFLEHWQWDW---QYLGDVHWPFRVLR-KARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQScvf
...||.|..   .  ...   .. .  |. .    .. . ..   .. . . ..  |. .| | |. ..|.......|.. .      |    .|.|   
ierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlks...

VRLQRRLSVSSVLLYLFIYRVILRWIE
 | |.  || .|  | .|....|. ..
qRiqkpgsvqtvqqyqgifqivltyld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 295-516 3.4e-22 73.6 In-house 73-288 (305) alignment 
Range on Protein: 295-516
Range on HMM: 73-288/305.0
TDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTlgpldsanrNHCPYYWPRAENESLRFGSF-HITCMKVDSKADPLF
 ..||||||      . |||.||||..|  ||| | .|.| . | ||   ..  .         ..|  |..  ... | |    .   .|..| .   |
heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekga.........kkcleyfaskdkdvlefeekgqkisvkfessvtlkf

T-ITKLKVQKVGgNLLDAEFDEELFLEHWQW-DWQYLGDVHWP---FRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKS-LILQSc
.  .| ||..    ...    . .   |. | ||   |        . .| ||| .  |..| |  |  ..|..| .|  |  .. |  | ..  |||  
rkdakakvtetv.lviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqk.

vfVRLQRRLSVSSVLLYLFIYRVILRWIE
  .| ||  |. .   |||...||| ...
..ireqrnnsiqtdaqylfvhqvilnyfr
subfamily_PTPRA_pd Subfamily PTPRA 291-514 7.5e-22 72.6 In-house 82-294 (330) alignment 
Range on Protein: 291-514
Range on HMM: 82-294/330.0
TYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNHCPYYWPraENESLRFGSFHITCMKVDSKAD
   ..|.| | ...|    ..|| || |...| ||||||... | . ||||           |.  ... |  |||  .. .. .|  ...  ..    |
GveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte.........lkerkeekcaqywP..deGlvtyGnirvevedetvlvd

plFTITKLKVQKVGGNLLDA--EFDEELFLEHWQ---WDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETaLMHFIRGSPITKslILQ
  .|. |. ||... .  .      . . .. |       .  | ..   .| .. .| . | .| |  |  ..||.. ... ... ..   .    . .
..ytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda.vlervkaerkvd..vfe

SCVFVRLQRRLSVSSVLLYLFIYRVILRW
    .||||   | .   | |||.|.| .
fvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 294-512 2.8e-21 71.3 In-house 52-252 (284) alignment 
Range on Protein: 294-512
Range on HMM: 52-252/284.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNsavdsstlgpldsanRNHCPYYWPRAENEslRFGSFHITCMKVDSKADplF
 .|.| | ...|    . .| .| ||.|| .|||||... .|  ||.|                ...|  |||   ..  . . |..    |.  ..  .
fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...............kdkcsqywplkivi..keerfkvkvdsveesee..y

TITKLKVQKVGGNLLDAEFDE---ELFLEHWQWDWQY-LGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVF
.. .... . | .    .  .     . .. . |    |  .    | |..  .  .. .| |  |. ..|. . ... |  . . . .    . .    
vvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvd...vynfvrd

VRLQRRLSVSSVLLYLFIYRVIL
.| ||   | ..  | |||  .|
lrqqrntlvqdlvqykfiysall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 294-512 3.2e-21 71.0 In-house 88-288 (319) alignment 
Range on Protein: 294-512
Range on HMM: 88-288/319.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNsavdsstlgpldsanRNHCPYYWPRAENEslRFGSFHITCMKVDSKADplF
 .|.| | .|.|    . .| || ||.|| .|||||... .|  ||.|                ...|  |||   ..  . . |..    |.  |.  .
fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...............kdkcsqywplkivi..keerfkvkvdsveetae..y

TITKLKVQKVGGNLLDAEFDE---ELFLEHWQWDWQY-LGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVF
.. .... . | .    .  .     . .. . |    |  .    | |..  .  .. .| |  |. ..|. . ... |  . . . .    . .    
vvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvd...vynfvrd

VRLQRRLSVSSVLLYLFIYRVIL
.| ||   | ..  | |||  .|
lrqqrntlvqdlvqykfiysall
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 270-514 4.9e-21 69.7 In-house 47-292 (301) alignment 
Range on Protein: 270-514
Range on HMM: 47-292/301.0
RNGMFSDEHEFLQEEgyTAKSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAE
.|    |..... ..  . . .  ....| |.|..|    . || ||.|.|.|  ||||...||| . |||.    .           ...|  |||..|
knitvyddnriilkp..kpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke.........gtkskceqywpnse

NESLRFGSFHITCmkVDSKADPLFTITKLKVQKVGGN---LLDAEFDEELFLEHWQ------WDWQYLGDVHWPFRVLR--------KARQLSTPTIVQC
.|| .|| |..|   |.... | |.| .|.|.   |     .  .|. .   . |.       ||   | |. |  ||.        . .    | .| |
aeseefgpftvtl..vneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHC

IDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQRRLSVSSVLLYLFIYRVILRW
 |. |.||. .|.. .|    .   .    . |    || ..   |     | .|| || ..
SdtVsrsGvYcsvsiglEQckaegVVd...vfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 289-512 5.5e-21 69.4 In-house 75-287 (310) alignment 
Range on Protein: 289-512
Range on HMM: 75-287/310.0
KSTYGttDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENeSLRFGSFHITCMKVDSK
|| |.  |.|||||||   | .||||.| ||. |  |||||.|||... |..|  ...           | .|  |||     .  .|   .| .   |.
ksrye..dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvge.........egrpkcvgywpslgv.tetygcirvtnlsesse

AdplFTITKLKVQKVGGNLLDAEFD---EELFLEHWQW-DWQYLG--D--VH-WPFRVLRKARQlsTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPIT
    | | .| |  |  |.   |     .|| ..  .| .|   |  |  .|  | |.| . |.   | .|.|  |  . ...|... .. .  ||  . 
e...feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvvalklkidkldrglkvd

KSLILQScvfVRLQRRLSVSSVLLYLFIYRVIL
   .      .. .|   . . | ||.| || .
aeevkte...llksraiciqtelqyliidrvri
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 294-513 6.7e-21 69.5 In-house 76-277 (315) alignment 
Range on Protein: 294-513
Range on HMM: 76-277/315.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAeneSLRFGSFHITCMkvDSKADPLF
 .|.. ||...|    . .|.||.|. .. .||||.||.|..  ||||.. |.          .....  |||      . .| . .| .  . .    .
hsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlveg.........ekrkaekywpdk...kviyGkitvtrk..seevntey

TITKLkvqkvgGNLLDAEFDEELFLEHWQWDWQYLGDVHWPF-RVLRKARQLST----PTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCV
|.  |          . .  | . |..  |    .     |.  . |...|  |    . .| | .|  ..||...... | .      |    . . . 
tvrtl......svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaid...vynfit

FVRLQRRLSVSSVLLYLFIYRVILR
 || .|.  |...  | ||| ..| 
gvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 295-513 8.2e-21 69.1 In-house 72-275 (315) alignment 
Range on Protein: 295-513
Range on HMM: 72-275/315.0
TDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADplFT
 |.| | |.|.    ...|..|.||| . .||||||.|||   |||..          ..  .. .|  |||  . .| .|||.... ..... .|   .
sdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk.........kqegdkikcrqywPdrkadsvefGsikvellsleadtd..gv

ITKLKVQKVGGNLLDAEFDEELFLEHWQwDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQR
. || ..|       . |. . . ..   | |    ..    |  . ..   . .| |  |  ..| ..||.  . .  |.. .    ...    .| .|
arklvtrkseesrtvtqfqftewPdkGv.dkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvd...vfnfvknlrakr

RLSVSSVLLYLFIYRVILR
   | .   | ||| ..| 
pylvqteeeyafiydavle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 262-514 1e-20 69.0 In-house 53-267 (274) alignment 
Range on Protein: 262-514
Range on HMM: 53-267/274.0
RlddrnelrngmfsdeheflqeegytakstYGTTDFIHANYVKGGP-LLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNH
.                                ...| |||.||     .... .| || || .|||||..||..| ||||           |  ||.. 
e.............................dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltk.........lkeaneqk

CPYYWPRAENE--SLRFGSFHITCMKVDSKADplFTITKLKVQKVGGNLLdaefdeelF---------LEHWQWDWQYLGDVHWPFRVLRKARQLS-TPT
|  |.| ||.   | |.| ..|.  |. .. |  ....|| ....  .                     ..   | . | |.    .  |....   .|.
CavyfPdaedyeiserygdveikvekivernd..ysvrklvlkylerers........vkhywytdWPdhksPddantlldlvleveesreeenaklapv

IVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQRRLSVSSVLLYLFIYRVILRW
.| |  |  . |  ..|. |. .. . . .    .|.  . .||.|   | .   | .|.|..  .
vvhCsaGiGrtGcfiaisiavrqlreeivvd...vlkivcnlrldrGGmvqtseqyelihralcly
subfamily_PTPN9_pd Subfamily PTPN9 293-402 1.9e-20 68.1 In-house 68-166 (297) alignment 
Range on Protein: 293-402
Range on HMM: 68-166/297.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLRFGSFHITCMKVDSKADpl
 ..|.|.||.| |    ..|| .| |||.| .||||||.....  |||    |.           |  |  |||  |..| .||..... ..|... |  
easdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvver.........grlkcgqyWpleeessaefgdlsvsnveveeeed..

FTITKLKVQK
.....|....
ykvrvleikn
0051429 (Phosphotyrosine protein) phosphatases II 294-519 3.1e-20 68.4 In-house 3-229 (272) alignment 
Range on Protein: 294-519
Range on HMM: 3-229/272.0
TTDFIHANYVKGGPL---LNTFICAQAPLKNTQEDFWRMvFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWP----------RAENESLRFGSFHI
... |.|..|.|       ........||..|..||||.  ....  ||.| | .           .|. |..|||            . .. ..| ...
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeEr.........grlkcdrywpgirylhlpilddsaptilygalrv

TCMKVDSKADPLFTITKLKVQKVGGNLldaefdeelfLEHWQWDWQYLGDV----HWPFRVLRKARQlSTPTIVQCIDGCSKSGTLVSIETALmhfiRGS
|....  . | . .   |. .   |.           .|.... ..   |     ..  ..|.  .. . | .| |  |.. .||.| .   |    .| 
tllseellldyilrellltlllsagea..........revmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll....lgv

P---------ITKSLILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWIEPYV
.          |   ...    .| ||. .| .   |||.|...| ..... 
sletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
0049772 (Phosphotyrosine protein) phosphatases II 230-519 3.7e-20 68.3 In-house 40-284 (314) alignment 
Range on Protein: 230-519
Range on HMM: 40-284/314.0
QTAFNANyLTKARSKMVPCAEfSRVKLnDGLGRlddrnelrngmfsdeheflqeegytakstYGtTDFIHANYVKGGpllNTFICAQAPLKNTQEDF---
.  . .|  .| |.. ...|. .||.| .||.                              .| .|.|.|.||.|    ..||..|.||..| .||   
vadlfln.rdknryldilpad.nrvil.pglpv.............................sg.sdyinasyvdgf...lkfIatqgpleitvvdfree

-------WRMVF--QEKCQFIVMLNSAVDSSTLGPLDSA-----NRNHCPYYwpraeneslrfgsfhitcmK----------Vdskadplftitklkvqk
       ||||.  . ..  ||| ...|  . |  ||.|     ... ....                                                
pvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...................neptaadlellk.................

vggnllDAEFDEELF----LEHWQWDWQY-----LGDVHWPFRVLRKArQLSTPTIVQCIDGCSKSGTLVSieTALMHFIRGSPITKSLILqscvfVRLQ
      .  .| |||    ........       | |.   ......| .  .|..| | .|.. .||.|   .|..   .| .. . |       |||.
......eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvv..aaylmkllgvsleealed.....vrlk

RR-----LSVSSVLLYLFIYRVILRWIEPYV
|       .. . ..|.||....| ... . 
Rpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 294-517 4e-20 67.1 In-house 45-257 (290) alignment 
Range on Protein: 294-517
Range on HMM: 45-257/290.0
TTDFIHANYVKGGPLLnTFICAQAPLKNT-------QEDFWRMVFQEKCQFIVMLNSAVDSSTlgpldSANRNHCPYYWPRAENESLRFGSFHITCmkVD
. |.||||.|.    |  .|  |.|....        |.|| |. ||| . .|||    . |.       ..  |  | | ...|.|.|. . . |   .
nddyiHAnrvtcpngl.rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksa.....ntslfaCakYvpesvgeelkfkgltvkC..ks

SKADPLFTITKLKVQKVGGnlldaefdEELFLEH-WQWDWQYLG---DVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFI-RGSPITKS
  ..  . . .| |.  ..        ||. ..| .  .|..|    |      ...| ..  || || |.|| |.| .| .|. .   ..   . ..  
kekeddvetRelvvkfdde........eeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkle

LILQScvfVRLQRRLSVSSVLLYLFIYRVILrwieP
 .|..   .| || | ..| | . |.  .|.     
dvlka...lrkqralaitsalelafvdagiv....l
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 295-513 6.4e-20 65.7 In-house 71-274 (515) alignment 
Range on Protein: 295-513
Range on HMM: 71-274/515.0
TDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNHCPYYWPRAENESLRFGSFHITCMKVDSKADplFT
 |.. | |...    ...|..|.|.| . .||||.|.||.   |.|..          |   .. .|  |||    .|..|||...  . ... ..   .
sdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk.........lkegdkikcgkyWPdkpgdsvkfGsikvelvsleactg..gi

ITKLKVQKVGGNLLDAEFDEELFLEHWqWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVRLQR
. ||.| |       . |. . . ..   . .    . .   |  .  |.. | |. |  |  . | ..||.  . |   .  .    ...    .| .|
krkltvlkgddsrtvtqfhfteWPdkG.vpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvd...vfnfvtnirqkr

RLSVSSVLLYLFIYRVILR
   |     | ||| ..| 
pylvqtqeqyafiygavle
subfamily_CG7180_pd Subfamily CG7180 294-515 5.2e-19 63.0 In-house 69-290 (296) alignment 
Range on Protein: 294-515
Range on HMM: 69-290/296.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRnHCPYYWPRAEneSLRFGSFHITCMKVDSKadPLF
..|.| | || .    . .|  .|| |.| ..|||.|..|... .|.|    | .         .  .| |||       ..| . .  .....   . .
ksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfa.........k.mypsywpnks..keqygeifveiveekqy..anl

TITKLKVQKV----GGNLLDAEFDEELFLEHWQWDWQY----------LGDVHWPFRVLRKAR---QLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGS
.| ..|..|     . .  . . .. . .      |.           | ..    |..|.     .   |..| . || |.||  ..|. .|   ..  
kirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekee

PITkslILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWI
 .    . .    .| .|.  | .|  | .|| |.| ..
evd...vFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 291-517 5.9e-19 63.1 In-house 67-280 (287) alignment 
Range on Protein: 291-517
Range on HMM: 67-280/287.0
TYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRaeNESLRFGSFHITCMKVDskAD
     |.| | ...|    . || |..|. ||  .||... ... . ||||    .          ... |  |||   ..|. .| ..|. .. .    
kgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqeke.........ndeevcyqyWpe..eksvvlGeyniellnee..vn

PLFTITKLKVQKVGGNlldaefDEELFLEHWQ-WDWQYLGDVHWPFRVL-------R-KARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKS
  ... ||.|.. . .      .... .. .|  .|.  |.|. |  .|       . . ..  |. .| | |.  .|.......|.. .  .   |   
agyierklevknknka......gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvf

LILQScvfVRLQRRLSVSSVLLYLFIYRVILRWIEP
 .|.|    | |.  ||  |  | ||. ..|  .. 
qvlks...qriqkpgsvqtveqykfindivleylds
subfamily_PTPN13_pd Subfamily PTPN13 296-513 1.1e-18 62.4 In-house 61-267 (273) alignment 
Range on Protein: 296-513
Range on HMM: 61-267/273.0
DFIHANYVKGG--PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLgpldsanrnHCPYYWPRAENESLRFGS-FHITCMKVDSKADpl
 .| |...|        ..| .| || .| .|||.||.. |.. |.|. . ...  .          |  |||  .|..|   . .... .||  . .  
gyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkv.........kchrywPesknkklkvsnrlevellkvqkldg..

FTITKLKVQKVGGNlldaEFDEELFLEHWQW-DWQYLGDVHWPFRVLRKARQLST---PTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQScv
|.. .|.|...  .    |  |   |.  .| | .         ..... |.| |   | .| |  |  .||||..|...|    |  ..  . |...  
fvvralavkdsesg....esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk..

fVRLQRRLSVSSVLLYLFIYRVILR
 .| ||.  | .   |.|.|..|| 
.lreqrqgvvqtkdqyifvykaile
0046846 (Phosphotyrosine protein) phosphatases II 293-515 2.6e-18 61.9 In-house 10-173 (176) alignment 
Range on Protein: 293-515
Range on HMM: 10-173/176.0
GTTDFIHANYVKGGpllnTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLGpldsanrnhCPYYWPRAENESLrfgsfhitcmkvdskadpl
.  |.|.||.. |.     .|. |.|| .| .||..|....... .|.|.. |. . |.         ||.|||. |....                   
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlk.........cpnywpeleklgi...................

ftitklkvqkvggnlldaefdeelflEHWQWDWQ-----YLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIEtaLMHF-IRGSPitksliLQS
                          ......|       | ...  .. .|.|..   |..| |  |.. .|||| .   |..     |.      .. 
..........................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay..llelekglsv......eea

CVFVRLQRR-LSVSSVLLYLFIYRVILRWI
  .|| ||.  .| .   | |.|...|...
lalvreqRplgavqtpeQyrflyefellll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 295-511 6.2e-18 59.7 In-house 57-262 (283) alignment 
Range on Protein: 295-511
Range on HMM: 57-262/283.0
TDFIHANYVK---GGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNsavdsstlgPLDSANRNHCPYYWPRaeNESLRFGSFHITCMKVDskADP
 |.| | ..         . .| ||.||..|. |||.|||.||   ||||          .|   .| .|  |||.  . |  .| | .|  |    .  
rdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt.........klqedlrikCsqyWPk..rGsedyGeftvtlrket..tsn

LFTITKLKVQKVggnlldAEFDEELFLEHWQW-DWQYLGDVHwPFRVL--------RKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITksl
 |.| .| ...       .   ..|.| |.|  ||   |.   .   |         . ..  .| .| |  |  ........ ... .    | .    
sfiikelllrvn......ssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvd...

ILQSCVFVRLQRRLSVSSVLLYLFIYRVI
. .    .| ||   | .   | ... ..
vfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 295-514 1e-17 59.1 In-house 59-269 (285) alignment 
Range on Protein: 295-514
Range on HMM: 59-269/285.0
TDFIHANYVK-GGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTlgpldsanrNHCPYYWPRAENESLRFGSFHITCMKVDSKADPLF
 |.|||....  |   .|.| .| || .|  |||.|..|||  ...|| . ..            ..|  |.|    | ..|| . ||  ..  .|    
rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv.........ekcalyypeklgevvkfgkyeitlteckeeaiagt

TITKLKVQkvggNLLDAEfDEELFLEHWQWDW---QYLGDVHWP----FRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSLILQS
 .  | |     |  ||   | |...| |  |   |   .   |    .. ..|     .|  |.|  |  .. |.| |. | .. .    |    |.. 
ilnaltvi....ntedas.seplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivre

CVFVRLQrrlSVSSVLLYLFIYRVILRW
   .|.|   .| | . .||.| |.. .
mramrfq...avqshmqflflyvvlmey
0043147 (Phosphotyrosine protein) phosphatases II 295-508 1.6e-17 59.2 In-house 5-154 (172) alignment 
Range on Protein: 295-508
Range on HMM: 5-154/172.0
TDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAvdsstlgpldsanrnhcpyywpraeneslrfgsfhitcmkvdskadplft
.|.|.|.|...    . ||. |.|| || .|||||. ..... ||.|..                                                   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

itklkvqkvggnLLDAEFDEELFLEHWQWDWQYLGDVhW------PFRVLRK--ARQLSTPTIVQCIDGCSKSGTLVSIETALmhfiRGSpitksLILQS
            |.|.|. |.| .... . |   |           .. ...  |.. . |..| |  |.. .|||| .   |    .|       ... 
............lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl.....sleea

CVFVRLQRRLSVSSVLLYLFIY
  .|| .|. .| .   | |.|
valvrekRpgavqnpsqyrfly
subfamily_PTPN1_pd Subfamily PTPN1 293-471 3.1e-17 57.2 In-house 54-227 (290) alignment 
Range on Protein: 293-471
Range on HMM: 54-227/290.0
GTTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAEN-ESLRFG--SFHITCMKVDSKa
. .|.| |. |.   .   .| .| || || . ||.||...|.. .||||  |.          ... |  |||. |. ..| .   ..... .. ..| 
adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvek.........eqikcaqywPqgeeekellledtklkvkliseerk.

dPLFTITKLKVQKvggnlLDAEFDEELFLEHWqWDWQYLGDVHWPF---RVLRKAR---QLS---TPTIVQCIDGCSKSGTLVSIETALMH
   .|. .|....     | ..   |..  |.   |  .|  . |    . | | |    ||    |... |  |  .|||.. ..| |..
.syytvrllelen.....lktqetreilhfhy.ttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvl
subfamily_PTPN14_pd Subfamily PTPN14 295-516 4.1e-17 57.1 In-house 76-297 (300) alignment 
Range on Protein: 295-516
Range on HMM: 76-297/300.0
TDFIHANYVKG--GPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRA--ENESLRFGSFHITCmKVDSKAD
|..| |  .|   |    ..| ||.||..| .|||.||.... | |||| .  ..          ....  |.|.   ......|| |..|  |  ...|
tgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed.........gkeksfkyfPkleskkktvefgkfkvtt.kfsedsd

PlFTITKLKVQKVGGN-------LLDAEFDEELFLEHWQWDWQYLGDVHWPFRVLRK---ARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITk
  .. |.||.. .  .       |  ... ..   |  .   .|| .|.   |   .   ... . | .| | .|  ..| |.  .  .  .  .  |  
s.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.

slILQSCVFVRLQRRLSVSSVLLYLFIYRVILRWIE
  | ..   .| || | |...  | |.|.|......
..ikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 294-514 6.7e-17 56.1 In-house 75-278 (439) alignment 
Range on Protein: 294-514
Range on HMM: 75-278/439.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTlgpldsanrnhcpyYWPRAENesLRFGSFhitCMKVDSKA-DPL
 . .| |||.||    . .| .|.| |.| .||||.|...|.  ||||   |.|                |||  ..    .|     ...|| .   | 
hshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..............ywpsdae..vcygdi...avrvdrnielpn

FTITKLKVQkvggNLLDAEFDEELFLEHWQWDWQ--YL----GDVHWPFRVLRKAR--QLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslIL
..|  .||     |  |    |   |.     |    .      |   .| .  |   .   | .|.|  |  ..||..... || ..     .    | 
yvirgfkvf....nerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvd...ik

QSCVFVRLQRRLSVSSVLLYLFIYRVILRW
    ..| ||.  | ..  |.|||  .|  
givkvlrkqrkqmvqalcqyvfiynavled
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 295-512 6.9e-17 56.1 In-house 65-274 (287) alignment 
Range on Protein: 295-512
Range on HMM: 65-274/287.0
TDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRNHCPYYWPRAeNESLRFGSFHITCMKVDSKaDPLFT
.|.| |||| .    ..||.||.|.  |  ||||.|....   ....   |. .         |..|  |||   .  .| | . .. .. | | .| ..
sdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveea.........rlkcykywPer.evPmrvGGysvvlldydik.ePeyg

ITKLKVQKVGGNllDAEFDEELFLEHW---QWDWQYLGDVHWPFRV------LRKARQlSTPTIVQCIDGCSKSGTLVSIeTALMHfiRGSPITKSLILQ
.  |.. .. ..  .|.  . | |  |         .| . . . |       |.| .   | .| .  |  .||.|...  .|..  |.  . .  . .
vralrlidletr..earvvkqldllswPdkvlaPtavglirfvldvkqhielardase.vGPlvvhddvGiGrsGillat.lvlvs..rledlGrvdvaa

SCVFVRLQRRLSVSSVLLYLFIYRVIL
  ...| .|.  | .|. . ..|  . 
vvirlreyraalvqavvqlrllyealv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 290-469 2.8e-16 54.5 In-house 24-196 (237) alignment 
Range on Protein: 290-469
Range on HMM: 24-196/237.0
STYGTTDFIHANYVKGG-PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENeSLRFGSFHITCMKVDSK
 . ...|.| |.|.||     ...|.|| ||... .|||.||.||||  ||||   ..          |. .|  ||| ...    .| . ..  | .  
gagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltglie.........gnelkchkywpstdq.paaygvltvslkkkeef

ADplFTITKLKVQKVGgNLLDAEFDEELFLEHWQWD--WQYLGDV-HWPFRVLRKARQ--LSTPTIVQCIDGCSKSGTLVSIETAL
.|  .|.  | ..| . .| .  .  .  .  |      |.   .  .  ... ...    |.| |. |  |  ..| .. |.. |
sd..ytvrslllskrl.tlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 297-466 1.3e-15 51.9 In-house 77-235 (301) alignment 
Range on Protein: 297-466
Range on HMM: 77-235/301.0
FIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSstlgpldsaNRNHCPYYWPRAENESLRFGSFHITCMKVDSKADPLFTIT
 ||||...     . ||..|.|||||.|||| |. | . . ||||   |.          . ..| .| |   .|.|. | |.|.  . ..  .   .  
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvek.........leekceeylpvkisekldigrfkikiknkelilnkkiskr

KLKVQKVGGNLLDAEFdeeLFLEHWQWDWQYLGDVHW-PFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIE
.|.|.   |..        .   . .|  . .   |   | ..  ...   | .|.| .|  .| .... |
tlevedstgkfatrtv...thyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigte
0036282 (Phosphotyrosine protein) phosphatases II 295-508 3.2e-14 48.5 In-house 2-163 (174) alignment 
Range on Protein: 295-508
Range on HMM: 2-163/174.0
TDFIHANYVKGGPLLNTFICAQAPLKntqedFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRaeneslrfgsfhitcmkvdskadplft
.|.|.|.....   .. .|. |.||.     ||.|....... .|||.. .           ..  |. |||.                           
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleeke.........lglykcinywpe...........................

itklkvqkvggnllDAEFDEELFLEHWQWDWQYLGDVHWP-----FRVLRKARQL--STPTIVQCIDGCSKSGTLVSIETALMHFIrgspITKSLILQSC
              . |. |.| ...... |   |    .     .. ...|..   . |..| |  |.. .|||| .   |.. .     .   .|.  
..............lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlv

VFVRLQRRLSVSSVLLYLFIY
  .||||  .| .   | |.|
relRlqrpgmvqtpsQyrfly
PTPc_DSPc_SM00012 434-512 3.8e-14 48.1 In-house 25-104 (105) alignment 
Range on Protein: 434-512
Range on HMM: 25-104/105.0
PFRVLRKARQL---STPTIVQCIDGCSKSGTLVSIETALMHFIRGSpiTKSLILQSCVFVRLQRRLSVSSVLLYLFIYRVIL
 .| ..| ..    |.|..|.| .|....||.| ....|... ...  ..  |.| .  .| ||. .|..   |||.||..|
llravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_ptpA1_pd Subfamily ptpA1 294-366 1.2e-13 45.5 In-house 74-136 (418) alignment 
Range on Protein: 294-366
Range on HMM: 74-136/418.0
TTDFIHANYVKGGpLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanRNHCPYYWP
 .|.| |||. |    . |||.| || ||  ||||||....|. ||||.   .           | .|  |||
gsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresenc.........rikcdrywp
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 294-388 3.4e-13 44.4 In-house 78-158 (297) alignment 
Range on Protein: 294-388
Range on HMM: 78-158/297.0
TTDFIHANYVKGGPLlnTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRnHCPYYWPraENESLRFGSFHITCMKVDSK
  |.. | .|||      .|. | | |.| .|||.||..|. . |||||          ..  .. .|  ||.  .. .  ||.  .. . |...
dsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnd.........dnerdk.kcaryWs..dkgvttfGdvsvvllsvser
0051082 (Phosphotyrosine protein) phosphatases II 295-511 4.2e-13 44.6 In-house 3-149 (151) alignment 
Range on Protein: 295-511
Range on HMM: 3-149/151.0
TDFIHANYVKGGpllntFICAQAPLKntqeDFWRMVFQEKCQFIVMLNSAVDSStlgpldsanrnHCPYYWPRAEneslrfgsfhitcmkvdskadplft
.|.|...|| ||     ... ..||     ||.... ..... ||.|.| .              .|| |.|...                         
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg...........ycpeylpelg.........................

itklkvqkvggnlldaefdeeLFLEHWQW-DWQYLgDV----HWPFRVLRKARQL-STPTIVQCIDGCSKSGTLVSIETALMHfirgspitkSLILQSCV
                     . . |... ||.   ..    ..  ..|.....  . |..| |  |.. .|||| .   |..           . .   
.....................ievlhipildwpdp.glplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.........vsleeale

FVRLQRRLSVSSVLLYLFIYRVI
..||.|  .| .   .||.....
eyrlkrpgvvqpnqqflfqlfal
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 297-524 6.2e-13 43.1 In-house 69-283 (312) alignment 
Range on Protein: 297-524
Range on HMM: 69-283/312.0
FIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTlgpLDSANrnHCPYYWPRAENESLRFGSFHITCMKVDSKADPLFTIT
.||||.||     . |.|.|.||.||   ||....   .  |..| . |. ..     .|.  .        . |  |  . . | ...  |.    |  
yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgs...ekcak..yisdivgfvdledhrvyteycteieiggkskdkithr

KLKVqkvggnLLDAEfDEELFLEHWQWD-WQYLG---DVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMhFIRGsPiTKSLILQSCVFVRL
 |||      .. |   .|  |.|.||  |   |    .   .|.|   ..   | | .|  |  ..|||. ||. .   .|  |  |  . .| |..| 
vlkv......vvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmia.alrh.p.rkqnvkdsfvllrk

QRRLSVSSVLLYLFIYRVILRWIepYVNKWYH
.|  ||  .  |..  |..| ..  | .  |.
drarsvrvfpqyvyalrcvlefl..yskglyk
0049260 (Phosphotyrosine protein) phosphatases II 307-508 9.4e-13 43.6 In-house 6-143 (152) alignment 
Range on Protein: 307-508
Range on HMM: 6-143/152.0
PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWpraeneslrfgsfhitcmkvdskadplftitklkvqkvggn
   . ||..|.|. || .|||||. . ... ||||.. ..          ..  |..|.                                         
ampfefiatqgpgpntladfwrmlkelgittivmltelle.........lgklkceqyi.........................................

lldaefdeelFLEHWQWDWQYLGDVHWPFRVLRK-----ARQLSTPTIVQCIDGCSKSGTLVSIETALmhfirgspiTKSLILQSCVFVRLQRRLSVSSV
             |..|.  .  | .  .. | .     |.. . |..| |  |.. .|||| .   |          .  ...   .|| .|  .| . 
..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnp

LLYLFIY
  . |.|
gqlrfly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 232-371 2.3e-12 41.3 In-house 42-156 (350) alignment 
Range on Protein: 232-371
Range on HMM: 42-156/350.0
AFNANYLTKARSKMVPCAEFSRVKLNDGLGRLddrnelrngmfsdeheflqeegYTAKSTYGTTDFIHANYVKGG----PLLNTF--ICAQAPLKNTQED
.   .  .| | | .   | |||||. .|                          . | .. | |.| |||.|           |  | .||||..| .|
seGvelfaknrYknilPYehsrvkLkkslkss......................dakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvdd

FWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENE
|...... | . |..|.| |.          |.. |  ||.. . .
fykvillnkvkvilsltsdve.........lnlekcyrYWqegsyd
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 294-387 3.5e-12 40.8 In-house 58-144 (297) alignment 
Range on Protein: 294-387
Range on HMM: 58-144/297.0
TTDFIHANYVK--GGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgpLDSANRNHCPYYWPRAENESLRFGSFHITCMKVDS
 .|.| |.||     .    .|.|| ||..| .|||..|...  . |||.           |    |. |  |||....| |. |.. .  .   |
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak.........lqedGrdkcapywpsvvqerlkagdvvveflssts
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 289-519 6.7e-12 39.4 In-house 69-289 (302) alignment 
Range on Protein: 289-519
Range on HMM: 69-289/302.0
KSTYGTTDFIHANYVKGGPLLNTFICAQAPLKNTQ---EDFWRMVFQEKCQFIVMLnsavdsstLGPLDSANrnHCPYYWPRAENESLRFGSFHITCMKV
| .    ....|  |.   | .. | || | ....   |.|||||||||.. .|.|        .|. .  .      ..|.  .. . .|.. .   ||
kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil........vgeeelkk..tlselfpkksgdykeygkmfvNnrkV

DSKADPLftiTKLKVQKVGGNLLDAEFDEELFLEHWQWD---WQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITKSL
... .     |.. .  .  .  .. . .   |. |. .    .|   ..    |  |  . . .|..    |. . |....  .|. .  .|.    . 
ekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnike

ILQScvfVRLQRRLSVSSVLLYLFIYRVILRWIEPYV
|..|   .| ||  .| |.  | ..|...| .|   |
ivks...iRsqRpravdslkQyvslyialllyikkkv
0044763 (Phosphotyrosine protein) phosphatases II 291-513 1.8e-11 39.5 In-house 14-169 (178) alignment 
Range on Protein: 291-513
Range on HMM: 14-169/178.0
TYGTTDFIHANYVKGGpllnTFICAQAPlkntqEDFWRMVFQEKCQFIVMLNSAVDSSTLGpldsanrnhCPYYWPRAENeslrfgsfhitcmkvdskad
 . ..|.|.|... .|     ..... |     .|..... ..... ||.|.. .    |.         |. |||. ..                    
glersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflk.........cdpywpeeag....................

plftitklkvqkvggnlldaefdeelfLEHWQWDW------QYLGDVHWPFRVLRKAR-QLSTPTIVQCIDGCSKSGTLVSIETALMHfirgspitKSLI
                           ... .. .      . |  ..  .. ...|. .   |..| |  | . ||||| .   ...        .  .
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsl

LQSCVFVRLQRRlSVSSVLLYLFIYRVILR
 .   .|| .|.  | .   . ..|.. ||
eeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_CG42327_pd Subfamily CG42327 294-406 3.7e-11 37.3 In-house 55-159 (319) alignment 
Range on Protein: 294-406
Range on HMM: 55-159/319.0
TTDFIHANYVKGGP-LLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdSSTLGpldsanRNHCPYYWPRAEN--ESLRFGSFHITCMKVDSKaD
 . ...|.||.|     | .|.||..|...  ||||.|.. . . || | .    | ||       . |. |.|  |   .   .| . .|  . ..| |
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd...lselG......ikvcaeylPtketldntslyGdilvtlkgrevk.d

PlFTITKLKVQKVGGN
  . |. | ...| ..
r.yaistlllkrvdke
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 294-348 8.5e-10 32.6 In-house 72-126 (392) alignment 
Range on Protein: 294-348
Range on HMM: 72-126/392.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSS
 .|.. | |...    ...|..|.|   . .|||||||||.   |.|..   .  
dsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 311-399 8.5e-10 33.1 In-house 5-82 (198) alignment 
Range on Protein: 311-399
Range on HMM: 5-82/198.0
TFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgplDSANRN-HCPYYWPRAENESLRFGSFHITCMKVDSKADplFTITKLK
 .|..| ||..|  |||.||..     |||.|           |  |..   |.||| .|. . ..||. .|.  . .|.|  .||| | 
ryiatqhplretladfwqmvwetgsghivmvnd..........dqknkeadypfywpttesgtgkygslsvttktittkpd..ytitali
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 311-399 9.5e-10 33.0 In-house 6-83 (199) alignment 
Range on Protein: 311-399
Range on HMM: 6-83/199.0
TFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSavdsstlgplDSANRN-HCPYYWPRAENESLRFGSFHITCMKVDSKADplFTITKLK
 .|..| ||..|  |||.||..     |||.|           |  |..   |.||| .|. . ..||. .|.  . .|.|  .||| | 
ryiatqhplretmadfwqmvwetgsghivmvnd..........dqknkeadypfywpttesgtgkygslsvttktittkpd..ytitali
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 294-343 1.4e-09 32.4 In-house 56-105 (267) alignment 
Range on Protein: 294-343
Range on HMM: 56-105/267.0
TTDFIHANYVKGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNS
. ..| | ||.|    |.||  | |||||. ||. .. ..|.  ||.|  
eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 230-346 1.3e-08 28.6 In-house 41-143 (349) alignment 
Range on Protein: 230-346
Range on HMM: 41-143/349.0
QTAFNANYLTKARSKMVPCAEFSRVKLNDGLGRLDDRNELRngMFSDeheflqeegytaksTYGTTDFIHANYVKGGPLL--NTFICAQAPLKNTQEDFW
. .   .  .| | | .   | |||||. .|      .. .    ||              .    |.| |||.|   .   . .|. ||||  | .||.
ilseGvelfaknrykdilPyehsrvklkkslksskvikast..sesd..............sgklddyinanylkltrisvekkyiatqaPlPstvddfy

RMVFQEKCQFIVMLNSAVD
...  .. . .. ||.  .
kvillngvklvlsLnddke
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 294-508 1.5e-08 29.1 In-house 35-234 (239) alignment 
Range on Protein: 294-508
Range on HMM: 35-234/239.0
TTDFIHANYVKGG-PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENeslRFGSFHITCMKVDSKADpl
 .|.| |.|..      ...|..|  .. .  |||||..||.   ||||   ..           ...|  ||| . .   ..  ...|  | .  ||  
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglie.........ghkkkchqywpdsts...kycnlrvtlrktevfad..

FTITKLKVQKVGGNLLDAEFDEELFLEHWQWDWQYLGDVHWPFRVLRK-ARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVR
. |  . . .||       ..  . .   .   ||   |    | . | .   . | ...|  |  ..|... |.. | .  .   .    |..    .|
yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd...ifnyvkair

LQRRLSVSSVLLYLFIY
 .|   | .   |.||.
edrphmvqtseqyvfih
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 294-508 1.5e-08 29.1 In-house 34-233 (239) alignment 
Range on Protein: 294-508
Range on HMM: 34-233/239.0
TTDFIHANYVKGG-PLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENeslRFGSFHITCMKVDSKADpl
 .|.| |.|..      ...|..|  .. .  |||||..||.   ||||   ..           ...|  ||| . .   ..  ...|  | .  ||  
hsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglie.........ghkkkchqywpdsts...kycnlrvtlrktevfad..

FTITKLKVQKVGGNLLDAEFDEELFLEHWQWDWQYLGDVHWPFRVLRK-ARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRGSPITkslILQSCVFVR
. |  . . .||       ..  . .   .   ||   |    | . | .   . | ...|  |  ..|... |.. | .  .   .    |..    .|
yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvd...ifnyvkair

LQRRLSVSSVLLYLFIY
 .|   | .   |.||.
edrphmvqtseqyvfih
subfamily_PTPRN_pd Subfamily PTPRN 291-371 3.6e-08 27.5 In-house 80-152 (297) alignment 
Range on Protein: 291-371
Range on HMM: 80-152/297.0
TYGTTDFIHANYV-KGGPLLNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENE
.  ..|.| |  . .  |   ..| .|.|| .|  |||.||... .  ||.| .  .          . ..|  |||   .|
saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrlee.........egvkqckrywpdeGse
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 309-380 3.7e-07 23.8 In-house 235-293 (440) alignment 
Range on Protein: 309-380
Range on HMM: 235-293/440.0
LNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAvdsstlgpldsaNRNHCPYYWPRaENESLRFGSFHI
 |.||..| ||  |  ||||.| . .   |.|||              | . |  |||  .  |. || | .
knafiatqmpldstvldfwrlvhdyristiimlnql............ndktcsiywpv.ntrsvtfgpftv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 322-475 7.7e-07 23.4 In-house 40-178 (255) alignment 
Range on Protein: 322-475
Range on HMM: 40-178/255.0
TQEDFWRMVFQEKCQFIVMLNSAVDsstlgpldsANRNHCPYYWPRAENESLRFGSFHITCMKvdSKADPLFTITKLKVqKVGGnllDAEFDEELFLEHW
| . |.... | | . .|||    .         .....|  |.|   .| |..    .|. |  | ||...   ..   ..|      . ..    .. 
tvdkfyqtivqtktevvvmlcdfae.........egvekcssyfplekdeklkladvnvtttk..ssadvvlrtleits.tlge...kkkthtvkhysyk

QWDWQYLGDVHWPFRVLRKARQLSTPTIVQCIDGCSKSGTLVSIETALMHFIRG
 |  .   .     . . |. . | . .|.|  |  .| ..| .| .  ..|| 
GWieknaPelareilnilkvvrdsksvvvhCstGiGrsaafvlaelvyqkmirs
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 294-359 4.4e-06 20.5 In-house 68-132 (303) alignment 
Range on Protein: 294-359
Range on HMM: 68-132/303.0
TTDFIHANYVKGGPLlNTFICAQAPLKNTQEDFWRMVFQEKCQFIVMLNSAVDSSTLGPLDSANRN
 . .|||.|..     .  | .| ||  |  |||.|. ..| . ...| .  .  .||      ||
dssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn