Gene egg-4 in Caenorhabditis elegans

Synonym: CELE_T21E3.1, egg-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily egg
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP052_AA protein Get Run
CeleP052_AA_391-663 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_egg_pd Subfamily egg 393-699 6.7e-190 624.3 In-house 1-307 (307) alignment
Range on Protein: 393-699
Range on HMM: 1-307/307.0
GAARKAKYLSTIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFW
.||.||||||.|....|||.|.||.||..|..|..|||||.||.|..|||||||.|..|...|||||.|||||||..||||.||||..|||.||||||||
eaakkakylseivqelerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfw

RMVWQEEVPYIVMLTSRKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILRLLRNA
|||.||||.||||||||||.|||||||||..||..|||||.|||||..|....|||||||.|.|.|.|.|||..|||||||||||..||||..||.|||.
rmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgdvnnssdvysplrvlrklrnl

SKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKELDVDYERWLQERSERMFLDDL
|||||..|.||||.||.|||.|||..||||||..|..|.|||.|||.||..|.|....|.||.|||.|||||||||||||||||||||.||||.||||||
skpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyerwleersekmflddl

AAPIPGY
|||||||
aapipgy

0040438 (Phosphotyrosine protein) phosphatases II 406-698 5.9e-63 208.4 In-house 18-310 (317) alignment
Range on Protein: 406-698
Range on HMM: 18-310/317.0
GGMERRFEILENSVNHiPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
..... || | .   . ......  .|..|.|.| . . |..|. |. . | .  |.|.|. ..|  | ..||.||.|..|||.|||||||.. | .|||
talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

LTSRKEPER--CEYYWPKspsdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA----SK
||. .|..|  |. |||       ... |...... ....  .. . ...|.. .  | |.|.| |..     | .  ... . |..|...|.|    ..
LteleelgrekcaqYwpl....getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpgg

PVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGsaKELDVDYERWLQERSERMFLDDLAA
||..| . ||.|.....||..... | ..   .. |. ||..||..|| ...||.||.|.......... ..   .| . .. ..|... . ..|||   
pvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylkrklt..lepaselklkllklliplalddvkl

PIPG
..  
keke

0036941 (Phosphotyrosine protein) phosphatases II 403-665 1.4e-61 203.8 In-house 10-280 (297) alignment
Range on Protein: 403-665
Range on HMM: 10-280/297.0
TIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqfprGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
. . .... || | .  . ........ .|.||.| . . . |.||. |    ..   |.|.|. ..|  | ..||.||.|..|||.|||||||.. |. 
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMLTSRKEPER--CEYYWPKSPSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIG-PDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRN----
|||||.  | .|  |. |||    .. .   |...... .|.. ... . ...|..    . |.|.| |..     | .  ....| |....|.|.    
Ivmltelvelgrekcaqywpleegeslty..gdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkl

--ASKPVVIHDHLGVSRAACLVAAEIAICSLLRG-PTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDV
   ..||..| . ||.|.....||..... | ..  ......  ||..||..||....|..||.|.......... .
lpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk

0051299 (Phosphotyrosine protein) phosphatases II 403-662 2e-61 203.3 In-house 20-286 (288) alignment
Range on Protein: 403-662
Range on HMM: 20-286/288.0
TIIGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
. . |... || | .   ........  .|.||.|.. . . |..|. |. . |.  .|.|.|. |.| .| ..||.||.|..|||.|||||||...|..
ngltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrv

IVMLTSRKEPER--CEYYWPKspsdPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIG---PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNA-
|||||.  | .|  |..|||       ... | .....  ... .|   |. ... ..   .| |.|.| |..     | .  ... . |..|||.|.| 
IvmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

---SKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
   ..|||.| . ||.|.....|...... |...  ..  | .||..||..||....||.||.||........
asgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 405-664 1.5e-59 197.2 In-house 41-301 (308) alignment
Range on Protein: 405-664
Range on HMM: 41-301/308.0
IGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqfprgQYLGDFIHANRISGK--PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
.|..|. || | .  .........  .|..|.| . . . |..|. |     .   |.|.|. ..|    | ..||.||.|..|||.|||||||...|..
lglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrv

IVMLTSRKEP--ERCEYYWPKSPSD-PAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDrEERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA--S
|||||.  |   | |. ||| .. . . .   |......  ... .|   |. .|. .| . |.|.| |..     | .  ... . |..|.|.|.   .
IvmLtklvengrekcaqYwplelgggsley..gkftvtllseevlddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpg

KPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
.|.|.| . ||.|.....|...... | ..  ..  |. ||..||..||....||.||.|..|........
gpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0045450 (Phosphotyrosine protein) phosphatases II 392-663 6.9e-59 195.4 In-house 13-305 (307) alignment
Range on Protein: 392-663
Range on HMM: 13-305/307.0
FGAARKAKYLSTIIGGMERRFEILENSVN--HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ-YLGDFIHANRI--------SGKPLFNEFIMT
..   ... | ... |... || | .      ........ .|..|.| . . . |.||. |. . |.   .|.|.|. .        .|  | ..||.|
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSpsdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG--PDREERHVEHWQG----D
|.|...||.|||||.|.. | .|||||. .| .|  |  ||| .     . . | ..... ....  .. . |..|..    .. |.|.| |..     |
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpd

VNNSSNMYSPLNILRLLRN------ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPTYK-YPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
 . .... . |......|.       ..||..| . ||.|.....|| .... | ...|.. .... ||..||..|| ....| ||.|..........
hgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

0046845 (Phosphotyrosine protein) phosphatases II 408-664 2.3e-58 193.2 In-house 2-276 (284) alignment
Range on Protein: 408-664
Range on HMM: 2-276/284.0
MERRFEILENSVNHI--PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ-YLGDFIHANRISGK-----PLFNEFIMTQAPMKNTVDDFWRMVWQEE
.|. || | . . ..  ......  .|..|.| . . . |..|. |. . |.   .|.|.|. ..|         ..||.||.|..|||.|||||||...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VPYIVMLTSRKEPE--RCEYYWPKSpSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNA-
|..|||||.  | .   |..||| . ... .   |......  ... .|   |.  |. .|.. |.|.| |..     | .  ... . |..|||.|.. 
vrvIVmltelvengrekcaqYwple.gevlty..gdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrell

-----SKPVVIHDHLGVSRAACLVAAEIAICSLLRGP-TYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
     ..|.|.|.. ||.|.....|...... | ..  .....|. ||..||..||....|..||.||......... 
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0039614 (Phosphotyrosine protein) phosphatases II 405-663 4.4e-57 189.1 In-house 32-290 (297) alignment
Range on Protein: 405-663
Range on HMM: 32-290/297.0
IGGMERRFEILENSVNhipFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ-YLGDFIHANRISGKPL-FNEFIMTQAPMKNTVDDFWRMVWQEEVPY
 . ..  .|.|.. ..   ...... .|..|.| . . . |..|. |. ..|.    |.|.|. ..|  |  ..||.||.|...||.|||||||.. |..
tllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtv

IVMLTSRKEPER-CEYYWPKSPSdpavtVPGGLRIENFGVYQapDPLFRVTHLRLIGpDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN------
|||||. .| .| |. ||| . .     . |...... .|..  .. . |..|..   . |.|.| |.|     | .  ... . |..|.|.|.      
ivmLtklvelgrkcaqywpeegg.....tygdftvtllkveh..ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelp

ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
 ..||..| . ||.|.....|| .... | ..  ... |. ||..||..|| ...|| ||.|..........
kggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydallellk

0043336 (Phosphotyrosine protein) phosphatases II 400-662 2.1e-56 186.8 In-house 14-277 (278) alignment
Range on Protein: 400-662
Range on HMM: 14-277/278.0
YLSTIIGGMERRFEILENSVNhIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEE
.| .   .... || | .    ........ .|..|.| . . . |..|. |.   | .  |.|.|. ..| .  ..||.||.|...||.|||||||.. 
lllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelg

VPYIVMLTSRKEPER--CEYYWPkspsdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN-
|. |||||. .| .|  | .|||       ... |...... ....  .. . |..|..    | |.|.| |..     | .  ... . |..|. .|. 
vttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrea

---ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
    ..||..| . ||.|.....|...... | ..   ..... ||..||..|| ...||.||.|.........
ledsngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 406-662 8e-56 184.8 In-house 12-272 (273) alignment
Range on Protein: 406-662
Range on HMM: 12-272/273.0
GGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqfprGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
..... || | .  .........  .|..|.|.. . . |..|. |    |.   |.|.|. ..| .| ..||.||.|..|||.|||||||.. |..|||
tllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVm

LTSRKEPER--CEYYWPKSPSDpAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN------A
||.  | .|  |..||| .  .  ... | ..... ....  .. . |..|.|    . |.|.| |..     | .  ... | |....|.|.       
LtelvelgrekcaqYwplegge.lsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

SKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
..|||.| . ||.|.....|...... | ..  ..  |  ||..||..|| ...|| ||.|.........
ngpvvVHCsaGvgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0040439 (Phosphotyrosine protein) phosphatases II 423-662 1.7e-54 180.4 In-house 2-246 (249) alignment
Range on Protein: 423-662
Range on HMM: 2-246/249.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWP
.....   .|..|.|.| . . |..|. |.  .| .|.|.|.|. |.|    ..||.||.|...||.|||||.|.. . .|||||| .|.  | |. |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

KspsdPAVTVPGGLRIENFGVYQAPDplFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN------ASKPVVIHDHLGVSRAAC
       ... |....... |.. .|  . |..|.|    | |.|.| |.|     | . .... . |......|.       ..||..| . ||.|...
l....ggsleygdftvtllsvevkdd..ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
..|| .... | .   ...... ||..||..|| ....| ||.|.........
fiaaylmleqleke..lgvdleeavkllrsqRpgavqnpeqyrflyeallell

DSPc_SM00195 409-662 5.1e-53 175.4 In-house 3-262 (263) alignment
Range on Protein: 409-662
Range on HMM: 3-262/263.0
ERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS
.. || ||.| .. ..|... ..|..| |   . . |.||. |. . ..   |.|.|| |.|.   ...|.||.|...||.|||||||.|.|..|||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

RKE--PERCEYYWPKSPSDPAVTVpgGLRIENFGVYQAPdPLFRVTHLRLIGPD-REERHVEHWQGDVNNSS----NMYSPLNILRLLRNA----SKPVV
 .|   |.|. |||..  .. .     .....  | . .   . ...|.|   . .|.| |...|    . .    .. | |..|| ...     |.|.|
eeengkekcdrywpeesggketfg..kisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

IHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
.| . ||.|....|...|.. .| .. .  . ..  |. ||. || ...| .||.|... .....
VhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 409-662 5.1e-53 175.4 In-house 3-262 (263) alignment
Range on Protein: 409-662
Range on HMM: 3-262/263.0
ERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS
.. || ||.| .. ..|... ..|..| |   . . |.||. |. . ..   |.|.|| |.|.   ...|.||.|...||.|||||||.|.|..|||||.
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

RKE--PERCEYYWPKSPSDPAVTVpgGLRIENFGVYQAPdPLFRVTHLRLIGPD-REERHVEHWQGDVNNSS----NMYSPLNILRLLRNA----SKPVV
 .|   |.|. |||..  .. .     .....  | . .   . ...|.|   . .|.| |...|    . .    .. | |..|| ...     |.|.|
eeengkekcdrywpeesggketfg..kisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

IHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
.| . ||.|....|...|.. .| .. .  . ..  |. ||. || ...| .||.|... .....
VhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0042113 (Phosphotyrosine protein) phosphatases II 425-662 1.5e-50 167.3 In-house 2-243 (245) alignment
Range on Protein: 425-662
Range on HMM: 2-243/245.0
THSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKs
....  .|..|.|.. . . |.||. |. . |..  |.|.|. ..|    . ||.||.|...||.|||||.|.. . .|||||.  | .|  |. |||  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

psdPAVTVPGGLRIENFGVYQapDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN-----ASKPVVIHDHLGVSRAACLVA
     ... |...... ....  .. . |..|..   .| |.|.| |..     | .  ... . |..|...|.     ...||..| . ||.|.....|
...gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

AEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
| .... | .   ...... ||..||..|| ...|| ||.|.........
aylmleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeallell

Y_phosphatase Protein-tyrosine phosphatase 432-659 9.7e-50 164.5 Pfam-A 1-234 (235) alignment
Range on Protein: 432-659
Range on HMM: 1-234/235.0
NQEKCRNPRVHCKDSTRIALqfpRGQY-LGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDpaV
|..|.|.. . . |.||. |   .|.    |.|.|| ..| .  ..||.||.|.|.|..|||||||||.| .|||||| .|   | |..|||.. ..   
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..s

TVPGGLRIENF-GVY-QAPDPLFRVTHLRLIGPDR-----EERHVEHWQgDVNNSSNMYSPLNILRLLRNAS----KPVVIHDHLGVSRAACLVAAEIAI
.  | ...|.   .  .  .  .|...|.  . ..     .. |...|. | .  ..  | |...| ... .    .|||.|   ||.|....||..|..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..| .. .    |  .|. ||..|| ....  ||||......
eqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 432-659 9.7e-50 164.5 In-house 1-234 (235) alignment
Range on Protein: 432-659
Range on HMM: 1-234/235.0
NQEKCRNPRVHCKDSTRIALqfpRGQY-LGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDpaV
|..|.|.. . . |.||. |   .|.    |.|.|| ..| .  ..||.||.|.|.|..|||||||||.| .|||||| .|   | |..|||.. ..   
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee..s

TVPGGLRIENF-GVY-QAPDPLFRVTHLRLIGPDR-----EERHVEHWQgDVNNSSNMYSPLNILRLLRNAS----KPVVIHDHLGVSRAACLVAAEIAI
.  | ...|.   .  .  .  .|...|.  . ..     .. |...|. | .  ..  | |...| ... .    .|||.|   ||.|....||..|..
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWp.dhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

CSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..| .. .    |  .|. ||..|| ....  ||||......
eqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail

0045098 (Phosphotyrosine protein) phosphatases II 417-662 2.6e-49 163.5 In-house 18-272 (278) alignment
Range on Protein: 417-662
Range on HMM: 18-272/278.0
NSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIAlqfprgqylgDFIHANRISGKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--R
   .   .|..   .|..|.| . . . |..|.           |.|.|. |.| |  ..||.||.|...||.|||||.|.. ...|||||. .| .   
llgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgyp..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

CEYYWPKspsdPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLI---GPDREERHVEHWQG-DVNNSSNMYSP-----LNILRLLRN--------------
|. |||       . . |....... ... .|   |. ... .    .| |.|.|.|..   .   .   .|     |..|. .|.              
caqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---ASKPVVIHDHLGVSRAACLVAAEIAICSLlrgpTYKYPVQRAVQFLRQRRPF-SIETPMQYIFVHRLVAFFF
    ..||..| . ||.|...|||| . .. |      .. .. ||..||..||. ......||.|...... ..
lldsggpvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllell

0037934 (Phosphotyrosine protein) phosphatases II 424-661 4.5e-44 146.2 In-house 2-241 (243) alignment
Range on Protein: 424-661
Range on HMM: 2-241/243.0
FTHSASDNNQEKCRNPRVHCKDSTRIALqfpRGqylGDFIHANRISGKPlfnEFIMTQAPMKNTVDD----FWRMVWQEEVPYIVMLTSRK--EPERCEY
|... . .|..|.| . . . | .|. |    |   .|.|.|| | . |    .| ||.|...||.|    ||||.|.. . .|||||. .  . | |. 
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPkspsDPAvtVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNS----SNMYSPLNILRLLR------------NASKPVVIHDH
|||    ..   . |...... .... .|   |. .|. ...| ..|.| |..          ... . |..|. .|            . ..||..| .
ywp....gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

LGVSRAACLVAAEIAICSLlrgptyKYPVQRAVQFLRQRRPF-SIETPMQYIFVHRLVAFF
 ||.|...|.|| . .  |      ..... ||..||..||. ...|| ||.|........
aGvgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_PTPRD_pd Subfamily PTPRD 408-659 5.4e-38 126.0 In-house 25-278 (564) alignment
Range on Protein: 408-659
Range on HMM: 25-278/564.0
MERRFEILENSvNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLT
.|.... .|.. .. ...... . |..| |   .   |..|. |.  .|.   |.| |. | |    ...| ||.|...|..|||||||....  |||||
feeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

SRKEPER--CEYYWPKSpSdpAVTVpGGLRIENFGVYQAPDPLFRVTHLrLIGPDREERHVEHWQGDV-NNSSNMYSPLNILRLLRN-------ASKPVV
. .| ..  |. |||.. .    |. |.| ..    ..  |  .|   |     ..| | |....     ..  . |. ..|.|.|.        ..|.|
kleEkgkvkchkYWPek.g..tety.geltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPiv

IHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
.|   || |  . .. .. .  .      .  .   |. ||. |.. ..|. ||||.|. ..
VhCSaGVGRTGtfividamlerike..ektvDiyqyvkalrkqRnamVqteeQYiFiheail

0041856 (Phosphotyrosine protein) phosphatases II 432-662 2.9e-35 116.9 In-house 1-171 (182) alignment
Range on Protein: 432-662
Range on HMM: 1-171/182.0
NQEKCRNPRVHCKDSTRialqfprgqyLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTsrkeperCEYYWPkspsdpavtvp
|..| | . . . | .|            |.|.|| . |   ...||.||.|...|| ||.||.... . .||.||       .|.|||           
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywp...........

gglrienfgvyqapdplfrvthlrligpDREER---HVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSllrgptyKY
                            ...||   .. ... . ..  .... |....  .. ..||..| . ||.|...|||| . ..        ..
............................ellerlgiqylylpwpDhgvpdldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.......gv

PVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
... ||...|.||| ...|| ||.|..... ...
sleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_PTPN9_pd Subfamily PTPN9 407-658 7.6e-34 112.1 In-house 17-286 (297) alignment
Range on Protein: 407-658
Range on HMM: 17-286/297.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|. . .. . |   .  |..| .  | || |   | | |.||. |.   ..   |.|.|| . |    . || || |.|.||.|||||||..||  ||| 
GlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

TSRKEPER--CEYYWPKSPSDpaVTVPGGLRIENFGVYQAPDPLFRVTHLRLIgPDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA--------
|   |  |  |  |||..  .  ..  | |...|  | .  |  .|| ... .  ..|.|.| |.|     |    |.  | |..|.  |..        
trvvergrlkcgqyWpleees..saefgdlsvsnveveeeedykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

---------SKPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
           |.|.|   |. |.  ... .|..  | .  . .  |. .|. ||..| ||| || || | .  |
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylav

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 424-664 8.3e-33 108.7 In-house 33-279 (307) alignment
Range on Protein: 424-664
Range on HMM: 33-279/307.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRgqYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPK
 |  | . |..| |   |.|.| .|| ..|.      |.|||| .      . || .| |..||. .|| |. ||.|  ..||    |    .|| ||| 
vtveafsantdknryqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpl

SPSDPAVT--VPGGLRIENFGVYQ-APDP-LFRVTHLRLIGPdREERHVEHWQGD-----VNNSSNMySPLNILRLLRNASKPVVIHDHLGVSRAACLVA
   .  |    |  . ..|.|. . |||  |  || |..    .. | ..|.| .          |. . .|.|   |    |||.|   || |.  .||
eegqklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinl.tainlleavrydtnpvvvhcsaGvGrsGtiva

AEIAICSLLRGPTYKyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
  .    ...|   |  ... |. ||..|...|.| .||...||..  .| .
islvqdkmiaGinck.dmkklveelrsqrhyaiqteaqylylhrvlleyfle

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 408-659 9.2e-33 108.6 In-house 22-277 (318) alignment
Range on Protein: 408-659
Range on HMM: 22-277/318.0
MERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLT
... .| |. | ...  ..| .. |. | |   .   |.||..||   |.   |.| || | |    ...| .|||. .|..|||||||. .   |||||
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

SRKEP--ERCEYYWPKSPSdpavTVPGGLRIENFGVYQAPDPLFRVTHLRLiGPDREERHVEHWQG-DVNNSSNMYSPLNILRLLRNAS--------KPV
  .|   .... |||.. |    .  | |..|     .  | . |  ...      |.|.|  ..  .  ...   |. ..| |.|..|        .|.
qeeergkakvhryWPskgs....rsygklvvelkeevelsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

VIHDHLGVSRAACLVAAEIAICSLLRGPTYkyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|.|   || |.   .| .| .  .    .    |   |. ||..|.  . |  ||.|..  . 
vvhCsaGvGrtGvfiavdillerikaealv..Dvfqtvkqlreqrnlmvqtedqyefiydvll

subfamily_PTPRB_pd Subfamily PTPRB 411-662 1.7e-32 107.6 In-house 30-285 (293) alignment
Range on Protein: 411-662
Range on HMM: 30-285/293.0
RFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK
..| |..  ..   . . .  |..| |  ..   | .|. |.  ...   |.| || |.|    .||| || |. .||||||||||....  |||||   
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlv

EPE--RCEYYWPKSpsdPAVTVPGGLRIENFGVYQAPDplFRVTHLRLIGpDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNAS------KPVVI
|    .|| |||.       .. | ....     .  |  . . .|..   ..|||.|....     | .  ..  . |...| .|.|       .|.|.
ekgkvkCeeYWPad...eepvlyGdikvtlvaeeeled..wvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
|   || |.  ..| .  . .. .  .    .   |. ||..| . . |  ||||.|. |  ..
hCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_Ptp69D_pd Subfamily Ptp69D 407-659 1.8e-32 107.7 In-house 23-283 (307) alignment
Range on Protein: 407-659
Range on HMM: 23-283/307.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|... .| ||..  .   . |. ..|. | | . ..  |.||. |.   |.   |.| |. | |   ...||. |.|. .|..|||||... ||  ||||
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

TSRKEPER--CEYYWPKSpsdpAVTVPGGLRIENFGVYQAPDP---LFRVTHLRLIGPDREER------HVEHWQgDVNNSSNMYSPLNILRLL----RN
.  .| .|  |. |||.       .  | . ..     ...|     . |..    ... |..      |   |. |..      . |.... .    ..
snlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykl

ASKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
   |.|.|  .||.|.. .|| .. .  |      |  .   |. ||..|.. ..   ||.|..| ..
nrsPivvhCsaGvgrsgifvaldsllqqlkae..dkvdifetvkdLrsqRnllvqsleqYvflyrall

subfamily_PTPRG_pd Subfamily PTPRG 406-657 2.9e-32 106.6 In-house 19-282 (563) alignment
Range on Protein: 406-657
Range on HMM: 19-282/563.0
GGMERRFE-ILENSVN-HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLG-DFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
 |... || . ..... ... .||   .|..| |.  .   |..|. |.   |.    |.| || | |    ..||.|| |.|.|.||||||.|...|  
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IVMLTS--RKEPERCEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPlFRVTHLRLIGPDR--EERHVEHWQgdVNNSSNMYSPLNILRLLRN-------
|||.|    .. . |. ||||  |    ..   |  |.  ....    . . .|.|   ..  .|..| ...    .  .. .|   |  | .       
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrt.lviknlklkkkkqcdteklvrqyh..ytkWPdhgvPehslpvLifvkkssaa

---ASKPVVIHDHLGVSRAACLVAAEiaicSLLRGPTY--KYPVQRAVQFLRQRRPFSIETPMQYIFVHRL
   .  |.|.|.. ||.|.  ... .    .||.      .  | . .. .| .|.| ..|  ||||.|  
nkaeaGPivvHcsaGvgrtGtyivld....tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhda

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 406-659 3e-30 100.4 In-house 23-280 (319) alignment
Range on Protein: 406-659
Range on HMM: 23-280/319.0
GGMERRFEILENSVNHiPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
 ..|. |. |...||   |...  ..|..| | . .   | ||..|.   |.   |.| |. | |    ..|| ||||..||..|||||||.||.  .||
tllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvm

LTSRKEPE--RCEYYWPKSpsdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQ----GDVNNSSNMYSPLNILRLLRNA-----SK
||  .|.   ... |||.      ... | | ..     .  |   |  .|.    . | |.| |.|     | .   .  | |..|. .|..     |.
ltklveklkvklkkywpee....nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsg

PVVIHDHLGVSRAACLVAAEIAICSLLRGPTYkyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|.|.|   || |    .. ....  . .  .    |   |. ||  |.. ...| ||.|..  . 
PivvhCsaGvGRtGtfivldamlervkeegvl..DvfstvsrlRtqRnimvqrpeqYkfiyeall

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 407-659 5.7e-30 99.3 In-house 22-276 (288) alignment
Range on Protein: 407-659
Range on HMM: 22-276/288.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|... .. | .  ..   | .   .|..| | . .   | .|. |.    .   |.| |. | |.   ...| ||.|. .||.|||..|.....  ||||
gfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

TSR--KEPERCEYYWPKSPSDpavTVPGGLRIENFGVYQAPDPLFRVTHLRligPDREERHVEHWQ------GDVN-NSSNMYSPLNILRLLRNAS-KPV
|.   .. ..|| |||..      .  | . ..  .. .  | . |   |     . .|... ..|       .|  .. ..   |...    .|  .|.
telveggktkCeeYWPdadkp...knyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpi

VIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..|   || |.   .|.. .|  . .  . .  |  .|. ||..|.. ..|  ||.|... ..
ivhCsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevll

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 413-663 6.2e-30 99.2 In-house 5-269 (274) alignment
Range on Protein: 413-663
Range on HMM: 5-269/274.0
EILENSVNHIPFTHSASD----NNQEKCRNPRVHCKDSTRIALQFPRGQY-LGDFIHANRISGKPL-FNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
. ||.   ..|  ..  .     .|.| |   .   . .|. |.   ..  . ..| || | |     . .. || |. |||.|||||..||||. ||||
kdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml

TSRKEPER--CEYYWPKSPSDPAVTVPGGLRIENFGVYQAPDplFRVTHLRLIGPDReERHVEH-WQGDVNNSSNMYSPLNILRLLRN---------AS-
|  || ..  |. |.|.. .       |.. |.. .. .  |  ..|..| |    | ||.| | |  |  .     .. ..|.|...         |  
tklkeaneqkCavyfPdaedyeiserygdveikvekivernd..ysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenakl

KPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
 |||.|   |. |. | .|..||.  | .  . .  | . |  ||. |   ..|  || ..|| .. . .
apvvvhCsaGiGrtGcfiaisiavrqlre..eivvdvlkivcnlrldrGGmvqtseqyelihralclylk

0051429 (Phosphotyrosine protein) phosphatases II 459-683 1.1e-29 99.3 In-house 3-246 (272) alignment
Range on Protein: 459-683
Range on HMM: 3-246/272.0
LGDFIHANRISGKPL---FNEFIMTQAPMKNTVDDFWRMvWQEEVPYIVMLTSRKEPER--CEYYWP--------KSPSDPAVTVPGGLRIENFGVYQAP
|.. |.|. ..|       . .. ...|...|..||||. ... . .||.|.|  | .|  |..|||          ....     | ||. .. ... .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYS--PLNILRLLRNaSKPVVIHDHLGVSRAACLVAAEIAIcsLLRGPTYKYP--------VQRAVQ
| . |.  |.|. .  | |.| |..       .  .   |..|.||.. ..||..| . |..| ...||. . .  |  . .  .         ...||.
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll..lgvsletivddYlltnlyleeave

FLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKELDVDYERWLQER
 ||..|| ...|..||.|... .. ..| ....  |    . ....|.
elraqrpgavqteeqylflyeallellrsllsvraeyllaaldaidee

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 410-659 1.5e-29 98.2 In-house 31-287 (298) alignment
Range on Protein: 410-659
Range on HMM: 31-287/298.0
RRFEILENSVN---HIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
  |. |..  .   .   . . ...|..| | . .   ||.|. |.   ..  .|.| |  ...    | ||.||||...|| ||||||..|..  ||||
lefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVml

TSRKEPER--CEYYWPKSP--SDPAVTVpGGLRIENFGVYQAPDplFRVTHLRLIgPDREERHVEHWQ-GDVNNSSNMYSPLNILRLLRN---AS--KPV
|. .| ..  .. |||..       .||   |. |.|. .      . |.. .     || |.... .  |   ..|. | |..||  |     .  |||
tnleeldktkyhkywPdegketygeitv.sllskeefadlivrk..lkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpv

VIHDHLGVSRAACLvaaeIAICSLLRGPT--YKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
...   || |.       ||| |.|       .  | ..|. ||..|| ...|  ||.|.. .| 
ivqCsaGvgRsGtf....iaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl

0046846 (Phosphotyrosine protein) phosphatases II 456-662 2.6e-29 97.6 In-house 8-173 (176) alignment
Range on Protein: 456-662
Range on HMM: 8-173/176.0
GQYLGDFIHANRISGKplfnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERC--EYYWPKsP-SDPAvtvpgglrienfgvyqapdplfrvt
 ..  |.|.|| | |      .| ||.|. .|. ||..|.... . ..|.||...| .|.   .|||    .                            
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi.........................

hlrligpdreE-RHVEHWQGDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICsllrgpTYKYPVQRAVQFLRQRRP-FSIETPMQ
          .  |.    ..| ... ... |...|  ... .||..| . |..|...|||| . ..       . ..|. |....|..|| ....|| |
..........qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllel......ekglsveealalvreqRplgavqtpeQ

YIFVHRLVAFFF
| |... . ...
yrflyefellll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 407-658 4.6e-29 96.4 In-house 16-272 (281) alignment
Range on Protein: 407-658
Range on HMM: 16-272/281.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|. . .| |..  .. . | | .|.|..| |   .   | ||. ..    .   |.| || ..|    .|.| ||.|. .....||.|||...|  |||.
GfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

TSRKEPE--RCEYYWPKSPSdpaVTVPGGLRIENFGVYQAPDplFRVTHLRLIGPDREERHVEH-----W--QGDVNNSSNMYSPLNIL-RLLR-NASKP
|   | .  .|  |||   |    .  | .....    . .   .   ...|   . |.|.||.     |  .|  ...... .  . . .| . .   |
treieagklkChrYWPddns...elkygdvtvkstaeeekat..yierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkap

VVIHDHLGVSRAACLVAAEIAICSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
.|||   || |. . .| . .. .. .  . .  |.  |. ||..| . . | .|| ||.. |
lvihCsaGvGrtGtyialDrlvkaveae.leeldvkavvaelrkernlmvqtvvqyefvykav

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 407-658 5e-29 96.4 In-house 23-279 (305) alignment
Range on Protein: 407-658
Range on HMM: 23-279/305.0
GMERRFEILENSvnHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVML
|.| ... | .   . ..    ...|..| |.  .   |  || |.    .   |.| |. . |    ...|..|.|.||||.||||....| |  ||||
gleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivml

T--SRKEPERCEYYWPKSPSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHW-------QGDVNNSSNMYSPLNILRLLRNAS--KP
|     . ..|. |||.| ...     | . .|     .|.| . |  ..     |.|.| | ..       .| .. .. . | .. ..  .. .  .|
tklveggkdkCrqYWpesktekkef..gefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

VVIHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
...|   ||.|.   .| .||.  | .  .    | . .. ||..|.  ..|  || |.|  .
llVhCsagvgRtGvfiavdialerlkkEev..vdvfevlkqlRskrmkmvqtldqYvflhdal

0049772 (Phosphotyrosine protein) phosphatases II 426-663 5.2e-29 97.4 In-house 40-281 (314) alignment
Range on Protein: 426-663
Range on HMM: 40-281/314.0
HSASDNNQEKCRNPRVHCKDsTRIALQFPRGQYlGDFIHANRISGKplfNEFIMTQAPMKNTVDDF----------WRMV--WQEEVPYIVM--------
 .    |..| |.... . | .|  |..  ..   |.|.|. ..|    . || ||.|...||.||          ||||  ..  | .|||        
vadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

-------------LTSRKEPErceyywpkspsdpavtvpG--------GLRienfgvyqapdplfrvtH---------------LRLIGPDREERHVEHw
             |..  ..                   .         |.                                 ||.  || ..   |. 
elsrLdaAlgKtpllildgng..................neptaadlellk.................eelydpelferlgikylripvpDgsaplled.

qgdvnnssnmysPLNILRLLRN--ASKPVVIHDHLGVSRAACLVAAEIAICSLlrgptyKYPVQRAVQFLRQRRP-----FSIETPMQYIFVHRLVAFFF
             . .|.....  . .||..| . |..|....|.| . .  |      ..... |....|..||      .||...||.|... .  ..
............fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefilealleyl

R
.
k

0043147 (Phosphotyrosine protein) phosphatases II 460-655 1.2e-28 95.4 In-house 5-154 (172) alignment
Range on Protein: 460-655
Range on HMM: 5-154/172.0
GDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRkeperceyywpkspsdpavtvpgglrienfgvyqapdplfrvthlrLIGP
 |.|.|. ...    ..||.||.|. ||..|||||.... . .||.||..                                              |  |
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

DREERHVEHWQ------GDVNNSSNMYSPLNILRL--LRNASKPVVIHDHLGVSRAACLVAAEIAIcsllrgptYKYPVQRAVQFLRQRRPFSIETPMQY
. .||.. ...      ..| ... ... |....   ... ..||..| . ||.|...|||| . .        ...... ||...|..|| ....| ||
ellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpgavqnpsqy

IFVH
.|..
rfly

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 437-663 2.5e-28 93.8 In-house 25-265 (270) alignment
Range on Protein: 437-663
Range on HMM: 25-265/270.0
RNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKP-LFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDPAVTVPGG
|   .  .  ||. |.  . .    .| || . |     ...| ...|...|. .||||.|.|.|. |||.|  .|   ..|| |||..| .   .  | 
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgk

LRIENfgVYQAPDPLFRVTHLRLIgPDREERHVEHWQ-------GDVNNSSNMYSPLNILRLLRNA---------SKPVVIHDHLGVSRAACLVAAEIAI
... .  . .. .  ...|.|||   . |||.. |..       | .... .  |. ..|..||.          ..|...|.  || |. .|.| .||.
ikvla..lseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiav

CSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
. | .  | |  | . .. ||. |.  ...| || |... |. . .
rlLee..tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae

subfamily_PTPN6_pd Subfamily PTPN6 407-663 5.1e-28 92.9 In-house 27-298 (306) alignment
Range on Protein: 407-663
Range on HMM: 27-298/306.0
GMERRFEILENSVNHIPFT--HSASDNNQEKCRNPRVHCKDSTRIALQfPRGQYLGDFIHANRISGK--PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
|.|  || |... ..  ..  ..|  .|.|| |   .   | ||. |.   . .  |.| || |...     ...| ||  ...|| |||||||||.   
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTSRKEP--ERCEYYWPKSPSDPAvtvPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRN-----
|||.|   |   |.|  |||.. ....    | ....|    .. |  .|  ..  .  ..|||.| ...     | .  .. .  |. |. ...     
ivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeel

---ASKPVVIHDHLGVSRAACLVAAEIAICSL-LRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
    . |.|.|   |. |   ..  .| .  .  .|  ... .|..|. .|. |   . |  || ||.. .... .
eeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyie

subfamily_PTPN12_pd Subfamily PTPN12 423-671 5.5e-28 92.7 In-house 31-286 (290) alignment
Range on Protein: 423-671
Range on HMM: 31-286/290.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWP
. ... ...|..| |   .   | .|. |.  ...   |.| || | |     |.| .|.|. .|.||||||.|. .|  .||.    | .  .|| |||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

KSPSDPAVTvpGGLRIENFGVYQAP-DPLFRVTHLRLIGPDRE--ERHVEHWqGDVNNSSNMYSPLNILRLLRNA----SKPVVIHDHLGVSRAACLVAA
..  ..  .  | .....    .   | | |  ...  .  |.    | ..|  | .  |.. | |....|.|.     ..|.|.|   || |.  ..| 
eegeeelef..gefevtleeekavdddflirtLkveaqkesrkvyqfhYtaW.PDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiai

EIAICSLLRGPT-YKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVIGSAKE
...   | .. .  .. |   |. ||..|.  . |  || .|.. || ...  ... .|
dyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 428-663 5.8e-28 92.4 In-house 51-290 (305) alignment
Range on Protein: 428-663
Range on HMM: 51-290/305.0
ASDNNQEKCRNPRVHCKDSTRIALQFPRgqyLGDFIHANRIsGKPLFNE--FIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSP
..| .. | |   | |.| . . |. |      |.|||| . | |.  |  || .| |. .|.|.|| || |. |  ||||    |    .|  ||| . 
sadiaitknryqdvpcqdqsavkldkps...psdyihanyv.gcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaq

SDpAVTVPGGLRIENFGVYQ--APDPLFRVTHLRLIGPDREERHVEH--WQ--GDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAI
 .  ... .|. .||    .    |.  ..| |.|     ..  | |  |    |        . |..|  .| .  |.|.|   |. |.  .|| |  .
ge.klelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyil

CSLLRgPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
  .        |.   |. ||..| |||.. .||.|.||..  .| 
ekiae.nkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 423-655 1.2e-27 91.3 In-house 45-276 (290) alignment
Range on Protein: 423-655
Range on HMM: 45-276/290.0
PFTHSASDNNQ--EKCRNPRVHCKDSTRIALQfprGQYLGDFIHANRISGkpLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYY
..  .  |.|   .| |   | | | ||. |.     | ||..||| . |  |   ||.|| ..|.|| |.|||| ||.| .||||    |    .|| |
ylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqy

WPKSPSDpAVTVpGGLRIEnFGVYQAPDPLFRVTHLRLIGPDREERH------VEHWQGDVNNSSNMySPLNILRLLRNASKPVVIHDHLGVSRAACLVA
.|.   . ..|  | . .      . .|       | .   |    |      .  |       |.. . | .|| ||.|| |||.|   |. |.  .||
ypekeGe.vltf.Geitvl.cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstl.allrtlrilrkasGpvvvhcsaGiGrtGtfva

AEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFVH
 |...  || |  ..  .   |. ||. |  |..  .||. . 
ievglqilldGkeld..lldlvralrnsrlnsvqvdiqylalv

subfamily_PTPRA_pd Subfamily PTPRA 424-682 1.2e-27 91.7 In-house 50-313 (330) alignment
Range on Protein: 424-682
Range on HMM: 50-313/330.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPK
.  .. ..|.|| | ...   | .|. |.  .|.   |.| |  | |    ..|| .| | ..||.|||||.|. .   |||||  ||   |.|. |||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

SPS----DPAVTVP-----GGLRIENFGVYQAPDPLfRVTHLRLIgpdrEERHVEHWQgDVNNSSNMYSPLNILRLLR----NASKPVVIHDHLGVSRAA
  .    .  |.|        . . .| | | ||   |  . ||.    .  | . |  ||   ..    |..|. ..    . . |.|.|   || |. 
eGlvtyGnirvevedetvlvdytvrkflvqqlpdat.rekksrlv....rqfhftswP.dvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtG

CLVAAEiAICSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFrdVIGsAKELDVDY-ERWLQE
 ... . |.   ..    |  | ..|. ||..||  . | .|| |... .  ..  . |   ||||   |. ||.
tfivld.avlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy..lyg.dteldvsslekhlqk

subfamily_PTPN13_pd Subfamily PTPN13 427-658 1.6e-27 91.5 In-house 32-265 (273) alignment
Range on Protein: 427-658
Range on HMM: 32-265/273.0
SASDNNQEKCRNPRVHCKDSTRIALQFPRGqYL-GDFIHANRisGKPLFnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPKSP
. ...|..| |   |   | ||. |.   | |.  ..|...   ||  . |.|..| |. .||.|||.|||. ..  |.|.|. || .  .|. |||.| 
gkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv..gkdey.eyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesk

SDPaVTVPGGLRIENFGVYQAPDplFRVTHLRLIGPD-REERHVEHWQ------GDV-NNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEI
... ..| . |..|. .| .  .  | | .| ..  . .| |.| | .       .| ... ..   .  .| |.. . |.|.|   |. |.  |.. ..
nkk.lkvsnrlevellkvqkldg..fvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidv

AICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
..  . |    ...|.  |. ||..|   . |  |||||.. .
vlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 407-659 4.1e-27 89.8 In-house 21-280 (290) alignment
Range on Protein: 407-659
Range on HMM: 21-280/290.0
GMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQ--YLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV
|.. .|. |... ..   |.  . .|... |  ..  .|  || |.   |.     ..|.|  | |    ...|.||.|..||. |||...|||.|. ||
gfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiiv

MLTSRKEPE--RCEYYWPKSPSDPavTVPGGLRIENFGVYQapDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSN-MYSPLNILRLLR--------NAS
|||. .| .  .|  |||.|...     .  ... |  ...  .   |  ...    . ....| ..|    .|   .  |  || ...        .  
mltniieegkvkCqqYWpdsdtka..ygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

KPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
...|.|   .|.|.| ..||...|       .    |   .. .|. .| |..|  || .....| 
tsivvHCSdtvgrsavfcaaattinkckt..egvidvfqvlksqRiqkpgsvqtvqqyqgifqivl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 430-658 6.2e-27 89.4 In-house 7-238 (250) alignment
Range on Protein: 430-658
Range on HMM: 7-238/250.0
DNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER-CEYYWP--KSPSDP
 .|.|| |   .   ||.|. |.  .|.   |.| |  . |    . ||.||.|...|. ||||||..|..  |||||. || |. .. |||  |.    
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyG

AVTVPgGLRIENFGVYQAPDplFRVTHLRLIGpDREERHVEHWQ-GDVNNSSNMYSPLNILRLLRN-----ASKPVVIHDHLGVSRAACLVAAEIAICSL
 |||   |  |.|. |.     . ... .  . .|  |.... .  |     .. . |..|. ..       ..||...   ||.|. . .| .  .  |
dvtvs.llskeefadytkrk..lklskakkad.erivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerl

LRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
 .    .  | . .. ||. || ..|.  ||.||....
kk..ekvvdvfkvikvlrkdrphavesleqyvfvyeii

subfamily_PTPN3_pd Subfamily PTPN3 411-658 6.6e-27 89.1 In-house 20-271 (280) alignment
Range on Protein: 411-658
Range on HMM: 20-271/280.0
RFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK
.|| |    . .  ...   .| .| |   .   |.||. |.  .  |.        | .. | | .| || |...|. |||.|||....  |||||.  
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlv

EPE--RCEYYWPKsPSDpaVTVPGGLRIENFGVYQAPDPLFRvtHLRLIGPD-REERHVEHWQ------GDV-NNSSNMYSPLNILRLLR-NASKPVVIH
|    .|  |||. ..|   .  |.....     .    ..|  .| |   . .|||.. . |       .| ..|... . .. .| ||  ...|||.|
erGrvkChqyWPe.ted..eleygefsvkcekedetksyvlr..elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvh

DHLGVSRAACLVAAEIAICsLLRGPTYKYPVQrAVQFLRQRRPFSIETPMQYIFVHRLV
   |. |.  |.. |.|.. |.      ||..  |. .|..|   ..|. || ||   .
CsaGigrtGvlilletala.lieaaepvypld.ivrtmrdqramlvqtasqykfvCeai

0049260 (Phosphotyrosine protein) phosphatases II 471-655 1.4e-26 88.5 In-house 5-143 (152) alignment
Range on Protein: 471-655
Range on HMM: 5-143/152.0
KPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWpkspsdpavtvpgglrienfgvyqapdplfrvthlrligpdreerHVEH
    .||| ||.|. ||..|||||...  . .|||||.. |  .  ||.|.                                             .. |
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylh

WQ---GDVNNSSNMYSPLNILRL--LRNASKPVVIHDHLGVSRAACLVAAEIAIcsllrgptYKYPVQRAVQFLRQRRPFSIETPMQYIFVH
..   . | ..| .   |...    ... ..||..| . ||.|...|||| . .        ...... ||...|..|| ....| |..|..
lpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_PTPRK_pd Subfamily PTPRK 424-657 1.6e-26 87.9 In-house 35-272 (314) alignment
Range on Protein: 424-657
Range on HMM: 35-272/314.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPK
.  .  |.|.|| |   .   | .|. |.   |.   |.| |. | .    ..||.|| |...|| ||||.|..|.   |||||  .|    .|  |||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

SpsdpAVTvPGGLRIENFGVYQAPDPLFRVTHLRL-IGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNAS----KPVVIHDHLGVSRAACLVA
     . .  | ...|   .    . . |.  ..    .  | | | ..|     | .   .  . |...| . . .     ..|.|   |  |. . .|
d....tev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

AEIaICSLLRGPTyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRL
 .| .. ...       |  ||. ||.|..  .||  ||.|..  
idi.vldmiereg.vvdvfnavktlrsrkvnmveteeqykfiydv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 407-659 2.2e-26 87.5 In-house 21-275 (287) alignment
Range on Protein: 407-659
Range on HMM: 21-275/287.0
GMERRFEILEN-SVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQfprgQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVM
| . .| .||. . ..   ||. . .|..| |  ..  .|  |. |.    .   |.| |  | |    ..||....|| ||. .||.......|. |||
gfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivm

LTSRKEP--ERCEYYWPKSPSdpavTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSN-MYSPLNILR----LLRNAS----K
|.  ||   | |  |||.. |    .| |  .||     .  . . |  ...  . . ....|. .|    .|   . .|  ||       ..       
lcqekendeevcyqyWpeeks....vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgnt

PVVIHDHLGVSRAACLVAAEIAICSLLRGPTykYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
..|.|   .| |.| ..||...|    .  .    | . ..  |...| |. |  ||.|.  .| 
sivvhCsdtvGrsamfcaaattinkckteGv..iDvfqvlksqriqkpgsvqtveqykfindivl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 417-691 2.8e-26 87.7 In-house 10-283 (284) alignment
Range on Protein: 417-691
Range on HMM: 10-283/284.0
NSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTsrkePERCE
 .||    |..  |.|..| |  ..   | ... |.   |.   |.| |  |.|    . .| || |..||..|||||.|. ..  ||.||     ..| 
lgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kdkcs

YYWPKSpsdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVE--HWQ-----GDVNNSSNMYSPLNILRLL---RNASKPVVIHDHLGVSR
 |||.     .|   .  ...   | .. .   |  .|   |  .. |..   |..     |  . .|..   .. .| |    |  ...|.|   || |
qywplk....ivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

AACLVAAEIAIcSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHrlVAFFFRDVIGSAKELDVDYERWLQERSERM-FLDD
.   .. .. . . ..    .  | . |. |||.|.  ..  .|| |..  .|.    ..| .     |.  .|.|.|... | ||
tgvyivldvll.drmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiy..salleehlfghsdvalpdfpayleelsnksdfddd

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 436-659 3e-26 87.1 In-house 45-268 (288) alignment
Range on Protein: 436-659
Range on HMM: 45-268/288.0
C--RNPRVHCKDSTRIALQfprgQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS--RKEPERCEYYWPKSPSDPAVTVP
.  |  .. . | ||. |.         .|.|| .| ..  . .| .|||.. |.. .|.|. ...| |||||.    |  |. . |.|    . |    
trdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

GglRIENFGVYQAPDPLFRVTHLRLIGPDREER-----HVEHWQGDVNnSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSLlRGPTy
          ..  | | .|. ||   .  |.      |. .|. |     |  |||..|  |..  ||.|.| . || |.. |.   ||. || | .  
l..ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgv.PenylsplrllevlkslqkPivvhssaGvGrtgtlililialesl.rldd.

KYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
   ... .. ||. |  .|.| |||..|||.| 
flgirsllaklreerfkaiqtemqylyvhrcvl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 416-691 4.7e-26 86.8 In-house 45-318 (319) alignment
Range on Protein: 416-691
Range on HMM: 45-318/319.0
ENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTsrkePERC
. .||    |..  |.|..| |  ..   | ... |.   |.   |.| |  ..|    . .| .| |..||..|||||.|. ..  ||.||     ..|
klgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt....kdkc

EYYWPKSpsdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVE--HWQ-----GDVNNSSNMYSPLNILRLL---RNASKPVVIHDHLGVS
  |||.     .|   .   ..   | .. .   |  .|   |  .. |..   |..     |  . .|..   .. .| |    |  ...|.|   || 
sqywplk....ivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvG

RAACLVAAEIAIcSLLRGpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHrlVAFFFRDVIGSAKELDVDYERWLQERSERMFLDD
|.   .. .. . . ..    .  | . |. |||.|.  ..  .|| |..  .|.    ..| .     |.  .|.|.|..  .||
rtGvyivldvll.drmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiy..salleehlfghsdvampdfpayleelsnksdfdd

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 431-658 1.9e-25 84.1 In-house 36-265 (281) alignment
Range on Protein: 431-658
Range on HMM: 36-265/281.0
NNQEKCRNPRVHCKDSTRIALQF-PRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSPSdpa
 |..| |   . | | .|. |..    .   |.|||| |    |   .|.|| | |.|  |||||.|||.   ||||    |   |.|  |.|.      
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah...

vtvpGGLRIENFGVYQAPDPL---FRVTHLRLiGPDREERHVEHWQG------DVNNSSNMYspLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAIC
      |..... |      .   .  |.| |   . | | . ||        .| .||..   |.||| .|  | | |||   || |.  |.| |||. 
....cclqfdklsvsyedstvnkslvttrlnl.syegetrlithwlwkewpdwqvpessevm..lkilrkirarstppvihcsagvgrsgtlmaveialq

SLLRGPTYKyPVQRAVQFLRQ-RRPFSIETPMQYIFVHRLV
|.    |    ... |  ||   |  |..|  ||... ...
sihshftlp.dikqivshlrvtgraasvqtlqqymliwkvl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 424-659 2.4e-25 84.3 In-house 43-281 (297) alignment
Range on Protein: 424-659
Range on HMM: 43-281/297.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLfnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE-PERCEYYWPKS
 | .    | || |   .   || |. |.    .   |.. |  . |     ..| || |||.||.|||.||..|.|  ||||.  .|  ..|  ||...
qtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdk

psdpAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPdREERHVE-----HWQ-GDVNNSSNMYSPLNILRLLR-----NASKPVVIHDHLGVSRAACLV
    .||  | . ..   | .    . |  ...   . . .| |.     .|   .|..  .. | |...  .|     ||. |...|   || |.. |.
....gvttfGdvsvvllsvsereGfikrelevtkgka.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

AAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
. .  ..   |  . .  .   |. ||| ||. . |  || ||. .| 
tidsvvaeakr..ekevdifglvkklrqerpylvqtkeqykfvyvavl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 431-664 2.7e-24 80.4 In-house 47-289 (305) alignment
Range on Protein: 431-664
Range on HMM: 47-289/305.0
NNQEKCRNPRVHCKDSTRIALqfpRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK--EPERCEYYWPKSPSDPAV
....| |   | | |  |. |   .| .  ..|||| .|     . || ||||...|  ||| | .|. | .| ||   .    ..|  |..    |   
qeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

TVPGGLRI----ENFGVYQ---APDPLFRVTHLRLIGPDREERHVEHWQ-GDVNNSSNMYSPLNILRLLRNA---SKPVVIHDHLGVSRAACLVAAEIAI
   .| .|    |  . ..     .   . | | . ||  . |.| |.   |  .     . | || || .|     |.|.|   |. |.  .|  |  .
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyil

CSLLRGPTYKyPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRD
  || |   .   .. .| .|..|  ||.|  ||.|||...  .||.
dqllagqiie.dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

0036282 (Phosphotyrosine protein) phosphatases II 461-656 3.9e-24 80.7 In-house 3-164 (174) alignment
Range on Protein: 461-656
Range on HMM: 3-164/174.0
DFIHANRISGKPLFNEFIMTQAPMKntvddFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPKspsdpavtvpgglrienfgvyqapdplfrvthlrliG
|.|.|. ...    ...| .|.|..     ||.|.... . ..|||.. ||..  .|  |||                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................l

PDREERHVEHWQG---DVNNSSNM-YsPLNILRLLRNA-----SKPVVIHDHLGVSRAACLVAAEIAICSLLrgptykYPVQRAVQFLRQRR---PFSIE
.. .||.. ...    . ..  ..    |........|     ..||..| . ||.|...|||| . .. ||       ... |....|..|   | ...
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll......eslvdaldlvrelRlqrpgmvq

TPMQYIFVHR
|| ||.|.. 
tpsQyrflyy

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 417-658 1.6e-23 78.0 In-house 18-262 (283) alignment
Range on Protein: 417-658
Range on HMM: 18-262/283.0
NSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLG-DFIHANRISGKplFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--
 || . . . ...|.|..| ||  .  .|  |. |.    .|.   ||  ..   .   ...|..|.|...|| |||.||..|..  |||||  .| .  
lsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykq..dkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

RCEYYWPKSPSDPAVTVPGGLRIENfgvyQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNIL----RLL----RNASKPVVIHDHLGVS
.|  ||||  |         || |            .   ||  .  ...  . |.| .   . .  ...| |    ..     ..   |.|.|   |. 
kCsqyWPkrGsedyGeftvtlrket....tsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiG

RAACLVAAEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFVHRLV
|.| ..||  ..  .|        |   |. .|..|.  . |  || .|| ||
rtavfiaasasvkdaltesvvd..vfavvkimreqrmmavqtldqyklvhelv

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 420-658 7e-23 75.5 In-house 31-272 (515) alignment
Range on Protein: 420-658
Range on HMM: 31-272/515.0
NHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEY
|  | | .  . | .| |   .   ||.|. |.    .   |.. |  | .    . .| .|.| | .||||||.|.||.|  |.|.| .|| .  .|  
niypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgk

YWPKSPSDpAVTVpGGLRIENFGVYQAPDPLFRvtHLRLIGPDReERHVE-----HWQgDVNNSSNMYSPLNILRLLRN----ASKPVVIHDHLGVSRAA
|||. |.| .|   | ...|   .    . . |  .|...  |   | |       |  |     .  | | ... ..      . |..||   || |. 
yWPdkpgd.svkf.Gsikvelvsleactggikr..kltvlkgdd.srtvtqfhfteWP.dkGvpkhtssllklikevkadhgqythpliihcsaGvGrtG

CLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
 .....  .       |    | . |. .||.||. . |  || |..  |
vvisidsvvahakt..trmvdvfnfvtnirqkrpylvqtqeqyafiygav

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 426-658 7e-23 75.9 In-house 38-273 (315) alignment
Range on Protein: 426-658
Range on HMM: 38-273/315.0
HSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSP
 .  ..|..| |   .   ||.|. |.    .   |.| |  | .    . .| .|.| | .||||||||.||.|  |||.| ..| ..  |  |||.  
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

SDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPDRE--ERHVEHWQGDVNnSSNMYSPLNILRLLRN----ASKPVVIHDHLGVSRAACLVAAEIAI
.| .    | ...| . . .  |   |   .|     |     . . |        .. | |.... ..        ....|   || |.  .....  .
adsvef..GsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGv.dkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

CSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
  . |.      | . |. ||. ||. . |  .| |..  |
aqikrtr..svdvfnfvknlrakrpylvqteeeyafiydav

0044763 (Phosphotyrosine protein) phosphatases II 445-658 7.2e-23 76.6 In-house 3-167 (178) alignment
Range on Protein: 445-658
Range on HMM: 3-167/178.0
DSTRIALQFPRGQYLGDFIHANRISGKplfneFIMTQAPMkntvDDFWRMVWQEEVPYIVMLTSRKEPER--CEYYWPKSPSdpavtvpgglrienfgvy
| ||  |. ..|   .|.|.|..| .      ......|.     |........ . .||.||. .|. .  |  |||.. .                  
drtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..................

qapdplfrvthlrligpdreeR---HVEHWQG-DVNNSSNMYSPLNILRLLR-NASKPVVIHDHLGVSRAACLVAAEIAICSllrgptyKYPVQRAVQFL
                         |.    . . . .. ..  ..... .. .  .||..| . ||.|...|||| . ..        ..... |....
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.......glsleeaielv

RQRRPfSIETPMQYIFVHRLV
|.|||  ...| |. ..... 
rerRp.ivpnpgqlrqLyefe

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 411-662 1.2e-22 75.0 In-house 15-277 (287) alignment
Range on Protein: 411-662
Range on HMM: 15-277/287.0
RFEILENSVNHIPFTHSASDN--NQEKCRNPRVHCKDSTRIALQfPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS
 .. | .  .  ..|  |...  . .| |   |   | ||. |    |..  |.| || ...    ..|| .|.|.  || ||||.|.....  ....| 
evdalkedsesstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr

RKEPERCE--YYWPKSpSDPAVtVpGGLRIENFGvYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNSSNMYSPL---------NI---LRLLRNAS-
  |  | .   |||.    |   | ||  .  .  |.  .| . |  ||||  . .| .| .    ..  ..  .|          ..   . | |.|| 
eveearlkcykywPer.evPmr.v.GGysvvlld.ydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardase

-KPVVIHDHLGVSRAACLVAAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
  |.|.||  |. |.  |.|  . .  |.   . .  | ..| .||..|   . ...|. ..   .. ..
vGPlvvhddvGiGrsGillatlvlvsrled..lGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_PTPN23_pd Subfamily PTPN23 406-658 2.3e-22 74.1 In-house 15-276 (288) alignment
Range on Protein: 406-658
Range on HMM: 15-276/288.0
GGMERRFEILENSVNHIPF--THSASDNNQEKCRNPRVHCKDSTRIALQfprgQYLGDFIHANRISG-KPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPY
......|. ||.. ..     . ...  . || |.  .   |..|. |.    .   |.| |  . .  |   .||.||||...|. |||.||... .. 
taldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssv

IVMLTSRKEPER--CEYYWPKSPSDPAVTVPggLRIENFGVYQAPDPLFRVTHLRLIGPDReERHVEHWQGDVNNS-SNMYSPLNILRLLRNASK-----
||||.|..| ..  .. |||..  .. .  .  |..    | ...    || .|.  ..|.  ..| | |     .     || ..|..| .. .     
iVmllskeelgkpkvdrYwPedkgetvkfgd..lsvtlksvretethvervlkletldada.vksvshlqltsWpelGvPasPetllqfldevesayeav

------PVVIHDHLGVSRAACLVAAEIAICSLLRGPTYKyPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
      |.|.|   || |.  .     |.  | .|.     . . |. ||. | |....  |. |.   |
qrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll.diiqvvsrlreqRrfmvqekeqlkfsyeav

0051082 (Phosphotyrosine protein) phosphatases II 460-656 2.6e-22 74.5 In-house 3-147 (151) alignment
Range on Protein: 460-656
Range on HMM: 3-147/151.0
GDFIHANRISGKplfneFIMTQAPMKntvdDFWRMVWQEEVPYIVMLTSRKEPERCEYYWPKSPsdpavtvpgglrienfgvyqapdplfrvthlrligp
 |.|..... |      .. ...|.     ||....... . .||.|.| .|.. |  |.|.                                      
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

dreeRHVEHWQGDVNNSSNM----YSPLNILRLLRNA-SKPVVIHDHLGVSRAACLVAAEIAICSllrgptykYPVQRAVQFLRQRRPFSIETPMQYIFV
    ..| |.. . .   ..     . |..|.||..  ..||..| . |..| ..|||. . ..         .... |....|..|| .. ...|..|.
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkrpgvvqpnqqflfq

HR
..
lf

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 410-660 1.5e-21 71.9 In-house 27-286 (325) alignment
Range on Protein: 410-660
Range on HMM: 27-286/325.0
RRFEILeNSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMV--WQeeVPYIVMLT
. |..|  |.. | .. ..  .|..| | . |   | .|. |.  . .   |.| |. .      . |. .|||. .|..|.||.|  |.   . .|.| 
hefgll.psddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr..csvvvvln

SR-KEPERCEYYWPKSPSDpAVTVpGGLRIENFGVYQAPDPLFRVTHLRLIGPD----REERHVEHWQ--GDVNNSSNMYSPLNILRL----LR---NAS
   .. .||  ||||  .. ..|  |||...   . .  | . || ... .        .. ..  |.  |  .  . . | |...      ..   .||
eldlgkdrcavywpkemgk.sktf.GglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkas

KPVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAF
 |...|   || |.  ...   |.  ..     .  .   |. ||. ||  .||  |||...  .. 
tpilvhcsaGvGrtGvfislysalakviees..rvdifgfvkklrkdrpsmvetvdqyiliyealve

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 418-654 1.4e-20 68.2 In-house 36-273 (301) alignment
Range on Protein: 418-654
Range on HMM: 36-273/301.0
SVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALqFPRGQYLGdfIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERC
....   |.| .  ...| | | | || || . . .  |. .   |||| |. .   . || ||.|.||| .||| |. | .|  ||||. . |   |.|
tidkdhitesyaylpkdkhryptvPckPstavev.ivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

EYYWPKSPSDPAVTVPGGLRIENFGVYQAPDPLFRVTHLRLIGPDREERHVEHWQGDVNNS----SNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLV
|.| | ..|.        ..|.|  .    .   |  ...    . . | | |.|                 ... |.... ||.|.|   |. |. ...
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafi

AAEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFV
..|.    ..  || .  ...|.. ||..|  .. |  |  ..
gteylareveadptie..ltealkhlrehrwngvqtnsqlywm

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 445-662 1.7e-20 68.3 In-house 31-259 (290) alignment
Range on Protein: 445-662
Range on HMM: 31-259/290.0
DSTRIALQFPRGQYLGDFIHANRISGkPLFNEFIMTQAPMKN-------TVDDFWRMVWQEEVPYIVMLTSRKEPER------CEYYWPKSpSDPAVTVp
  ||..|.    ..  |.|||||..  |   ..|.||.| ..       |. .|| |. ||.|  .|||  ..|...      |. | |.|  .  ... 
eatrvvLkgygkrfnddyiHAnrvtc.pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes.vgeelkf.

GGLRIENFGVYQAPDPLFRvtHLRLIGPDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAiCSLLRGPTYK
.|| ..     .  |   |  .| .   |.||  |.| .     ..|   .  . |.... ...   ||..|.. |.|| |.| | ... . .. . . .
kgltvkCkskekeddvetR..elvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilg.yQkiaetsgs

YPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
  .. ... ||..|   | ..... ||   . . .
vkledvlkalrkqralaitsalelafvdagivlla

subfamily_PTPN1_pd Subfamily PTPN1 416-653 7.3e-20 65.8 In-house 16-262 (290) alignment
Range on Protein: 416-653
Range on HMM: 16-262/290.0
ENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQfpRGQYlgDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS--RKEPE
..  ...| ...  ..|... |   |.  | .|| |.  |..   |.| |. .  . .  ..|.|| |. |||| ||.|||...   .|||     ||  
rkeasdfptreaklpenrnlnryrdvspydhsrikle..radn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

RCEYYWPKSPSDPAVTVP-GGLRIENfgVYQAPDPLFRVTHLRLIG-PDREERHVEHWQG----DVNNSSNMYSPLNILRLLRNA------SKPVVIHDH
.|  |||.  .. ....    |...   . .     ..| .|.|     .| |.. |.      |    .   . |. |  .|..        |.|||  
kcaqywPqgeeekellledtklkvkl..iseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

LGVSRAACLVAAEIAICSLLRGP-TYKYPVQRAVQFLRQRRPFSIETPMQYIF
 |. |.  .. ..  .  . .   .    ... .  ||. |   | |. |  |
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 422-540 1.5e-19 64.7 In-house 42-158 (310) alignment
Range on Protein: 422-540
Range on HMM: 42-158/310.0
IPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYlGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYW
  .|. |  ..  | |   | |.|..|. |.  . .| .|.|||| .  . | . || .| |.. |. |||||..||    |..|    |    .|  ||
ssltyeaykkymhknrysdvvcldtsrvklkidksry.edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PkspSDPAVTVPGGLRIENFG
|   |       | .|. |..
p...slgvtetygcirvtnls

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 426-658 1.6e-19 64.7 In-house 42-275 (439) alignment
Range on Protein: 426-658
Range on HMM: 42-275/439.0
HSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERceyYWPKSPS-
  | . .| | |   |   | ||..||   |     .| || | |    . .| ||.| |.|.|||||.|... .  |||||   |  .   ||| .   
laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...ywpsdaev

---DPAVTVPGGLRIENFGVYQapdplFRVTHLRLIGpdREERHV-----EHWQgDVNNSSNMYSPLNILRLLRNAS-----KPVVIHDHLGVSRAACLV
   | || |   . . |. .       |.|   |  .  . || |       |  | |  ..    |. || .  |       |||.|   || |.  ..
cygdiavrvdrnielpnyvirg.....fkvfnerdtt..ekertvlqfhyiawp.dknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtii

AAEIAICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
| .||.  |      |  ..  |..||..|   ...  ||.|..  |
aldialeqlkl..enkvdikgivkvlrkqrkqmvqalcqyvfiynav

subfamily_CG7180_pd Subfamily CG7180 426-522 3.1e-19 63.7 In-house 36-133 (296) alignment
Range on Protein: 426-522
Range on HMM: 36-133/296.0
HSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPER-CEYYWPKS
.    .|.|| |.. |   | .|. |.   |.   |.| |  . .    .|.|.|.||.|.|||.|||.|..||.  .|.||   . .. .  |||. 
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 407-525 3.4e-19 63.6 In-house 16-137 (301) alignment
Range on Protein: 407-525
Range on HMM: 16-137/301.0
GMERRFEILENSvNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRG--QYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV
..| ... |..  .. . | . |..|..  |.  .   |  || |.  .   .   ..| |. |.|    ..||..|.|||.|. ||||..||| .  ||
kfeeqykelkeg.edksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLTSRKEP--ERCEYYWPKSPSD
|.| .||   ..|| |||.|  .
mvtnlkegtkskceqywpnseae

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 423-521 1.8e-18 61.6 In-house 40-140 (315) alignment
Range on Protein: 423-521
Range on HMM: 40-140/315.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTS--RKEPERCEYYWP
|.  .   .|..| |   .   | .|. | .   .   |.. || | |    . .| .|.|  ..|.||||.|..|..  |||||.   .| ...| |||
pldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywp

K
 
d

subfamily_ptpA1_pd Subfamily ptpA1 405-542 3.9e-17 57.1 In-house 20-157 (418) alignment
Range on Protein: 405-542
Range on HMM: 20-157/418.0
IGGMERRFEILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKpLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIV
|  ..  | .||.||     .      |  | |   .   . ||. |.  . .   |.| || | |    ..|| || |. ||. |||||||.. .  ||
ihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriiv

MLTSRKEPE--RCEYYWPKSPSDPAVTVPGGlRIENFGVY
||.   |    .|. |||.      ... |    | || |
mlsresencrikcdrywpeqiggeqfsiygn.gnevfgty

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 423-658 4.7e-17 56.5 In-house 36-232 (392) alignment
Range on Protein: 423-658
Range on HMM: 36-232/392.0
PFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPErceyywpks
| | .  . |..| |   .   ||.|. |.        |.. |  | .    . .| .|.|   ..|||||||.||.|  |.|.|  || .         
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

psdpavtvpgglrienfgvyqapdplfrvthlrlIGPDRE---ERHVEHWQGDV--NNSSNMYSPLN-ILRLLRNASKPVVIHDHLGVSRAACLVAAEIA
                                   | |       |.  |  .   . .|..   .. .     . ..|..||   || |.. ... .  
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsv

ICSLLRgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLV
..   .  |    |   |  .|..||. ..|  || |..  |
vahakk..trmvdvfnfvtnirrkrpymvqtkeqyafiygav

subfamily_PTPN14_pd Subfamily PTPN14 413-527 8.9e-17 56.0 In-house 30-147 (300) alignment
Range on Protein: 413-527
Range on HMM: 30-147/300.0
EILENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQyLGDFIHANRISGK--PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRK
| . .  ..  .. .. ..|.|| | . |   . .|. |.  . .   ..| | .|.        ..|..|.|...|| |||.|||...|  |||||. .
eripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

EP--ERCEYYWPKSPSDPA
|   |..  |.||. |   
edgkeksfkyfPkleskkk

PTPc_DSPc_SM00012 576-659 1.1e-16 56.3 In-house 19-104 (105) alignment
Range on Protein: 576-659
Range on HMM: 19-104/105.0
SSNMYSPLNILRLLRNA---SKPVVIHDHLGVSRAACLVAAEIAICSLLRGPtYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|... . |. ..  .|.   |||||.|.. ||.|....||..|....| ..  ... ... |. ||..|| ...| .||.|..| ..
sdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqylflyrall

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 427-570 2.8e-16 54.2 In-house 28-170 (297) alignment
Range on Protein: 427-570
Range on HMM: 28-170/297.0
SASDNNQEKCRNPRVHCKDSTRIALQfpRGQYLGDFIHANRIS--GKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKS
.  ..   | |   .   |.||. |.  |.    |.| |. .    ..    .|..| |...||||||..|....|  |||..  .|   ..|  |||..
akrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

PSDPAVTvpGGLRIENFGVYQAPDPLFRVTHLRLIGPdREERHVEHWQ
  .   .  | . .|    .        .| |.||    |.|.| | |
vqerlka..gdvvveflsstsdefdrviltelqliyr.sesrvvrhvq

0048076 (Phosphotyrosine protein) phosphatases II 571-659 5.2e-15 50.9 In-house 59-140 (145) alignment
Range on Protein: 571-659
Range on HMM: 59-140/145.0
GDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICsllrgptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVA
|  . .. ... |.... .... .||..| . ||.|...|||| . ..       ...... |....|..||.....| |..|..... 
gvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.......lgvsleealelvrsqrpgavpnpgqlrflyefel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 431-523 6.1e-15 50.1 In-house 2-95 (237) alignment
Range on Protein: 431-523
Range on HMM: 2-95/237.0
NNQEKCRNPRVHCKDSTRIALQFPRGQylGDFIHANRISGK-PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSP
.|. | |   . . | .|. |. . ..   |.| |. . |     ...| .| |.... ||||.|||||    |||||   |   ..|  |||.. 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 409-661 8.7e-15 49.4 In-house 9-258 (267) alignment
Range on Protein: 409-661
Range on HMM: 9-258/267.0
ERRFEILENSV-NHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQylgdFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLT
|. || ...   ..   . | . .|||. |   .   | ||. |.    .    .| |  . |    | ||.|| |.|||. ||. .. ...|| ||.||
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

SRKEPERCEYYWPK---SPSDPAVTVPGGLRIENFgVYQAPDPLFRvtHLRLIGPDREERHVEHWQGDVNNSSNMYSPLNILR--LLRNASKPVVIHDHL
   . .   .. ||   .     .||   |  |.   ||     ..         .    . ..|. ..||   .   . ||    | |...|.|..   
kvftdnirlfwPPkmgqakkyqdltvehslekeen.dyqiitlelk..fknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsd

GVSRAACLVAAEIAICSLLRGPTYKypVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFF
|| |.  .. ..  .  . .  . .  .   .. .|..|.  ..|  .||..|.|.| .
GvGrsGtflvidsqleraktegvsd..ifdflrkirsqriglvdtkeryiyihellaey

0048179 (Phosphotyrosine protein) phosphatases II 571-656 1.2e-14 49.7 In-house 61-139 (144) alignment
Range on Protein: 571-656
Range on HMM: 61-139/144.0
GDVNNSSNMYSPLNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAIcsllrgpTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHR
|  . .. ... |.... ... ..||..| . ||.|...|||| . .       ....... |....|.|||.....| |..|...
gvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.......klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_PTPRN_pd Subfamily PTPRN 427-523 1.4e-14 48.5 In-house 51-150 (297) alignment
Range on Protein: 427-523
Range on HMM: 51-150/297.0
SASDNNQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRISG-KPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSP
. ...| .| |.  |   | .|. |.    .   |.| |  |    |    .| ||.|. .|| |||.|||.. |  ||.||. .|   ..|. |||.  
akaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeG





subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 432-658 3e-14 47.8 In-house 8-237 (239) alignment
Range on Protein: 432-658
Range on HMM: 8-237/239.0
NQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRIS---GKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDP
|. | |   .   | .|. |.    .   |.| |. .    | |  . .| ||  .. .  |||||.|||    |||||   |   ..|  ||| | |  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

AVtVPGGLR-IENFGvyqapDPLFRVTHLRLIGpDREERHVEHWQGDVNNSS--NMYSpLNILRLLRN-------ASKPVVIHDHLGVSRAACLVAaeia
.  .   ||  | |      | . |   .  .| . |||.| ...  |        |.   .| | |.        ..| |||   || |. ...     
cn.lrvtlrktevfa.....dyiirtfvmsqvg.qteeryvyqyhftvwpdkgvpqya.tavlglrrkitkdslpgarpwvihcsagvgrtgaflv....

ICSLLRGPTYKY--PVQRAVQFLRQRRPFSIETPMQYIFVHRLV
| ..||    .    .   |. .|. ||. ..|  ||.|.|  |
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 432-658 3e-14 47.8 In-house 7-236 (239) alignment
Range on Protein: 432-658
Range on HMM: 7-236/239.0
NQEKCRNPRVHCKDSTRIALQFPRGQYLGDFIHANRIS---GKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDP
|. | |   .   | .|. |.    .   |.| |. .    | |  . .| ||  .. .  |||||.|||    |||||   |   ..|  ||| | |  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp..kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

AVtVPGGLR-IENFGvyqapDPLFRVTHLRLIGpDREERHVEHWQGDVNNSS--NMYSpLNILRLLRN-------ASKPVVIHDHLGVSRAACLVAaeia
.  .   ||  | |      | . |   .  .| . |||.| ...  |        |.   .| | |.        ..| |||   || |. ...     
cn.lrvtlrktevfa.....dyiirtfvmsqvg.qteeryvyqyhftvwpdkgvpqya.tavlglrrkitkdslpgarpwvihcsagvgrtgaflv....

ICSLLRGPTYKY--PVQRAVQFLRQRRPFSIETPMQYIFVHRLV
| ..||    .    .   |. .|. ||. ..|  ||.|.|  |
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 487-662 1.4e-13 45.6 In-house 40-221 (255) alignment
Range on Protein: 487-662
Range on HMM: 40-221/255.0
TVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWPKSPSDPAVTVPGGLRIENfgvyQAPDPLFRVTHLRL-IGPDREERHVEHWQ--GDVNNS--SNM
||| |.... | .   .|||.  .|   |.|. |.|    .  .     .   .     . |...|  .. . .|  .. . |.|..  | ...    . 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

YSPLNILRLLRNAsKPVVIHDHLGVSRAACLVAAEIAIC----SLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
   ||||.. |.. |.||.|   |. |.| .| ||..      || . .| .    . .. ||..|. .|.||.|  |   .|  ..
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 425-521 1.7e-12 41.9 In-house 28-123 (285) alignment
Range on Protein: 425-521
Range on HMM: 28-123/285.0
THSASDNNQEKCRNPRVHCKDSTRIALQfprgQYLGDFIHAN--RISGKPLfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE--PERCEYYWP
|..| . | .  |   |.| . ||. |.    ..  |.|||.  |. ||   . .| || |. .|. |||.|..||.. |..|| .  |   |.|  |.|
tytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdq.styittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

K
.
e

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 461-523 2.3e-12 41.3 In-house 84-154 (350) alignment
Range on Protein: 461-523
Range on HMM: 84-154/350.0
DFIHANRISGK-------PLFnEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSP
|.| || .. .       | |  .| ||||...|||||.... . .|. |..|||  |   |.|. ||..  
DYinanYlkltrfsveinpdf.kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs

subfamily_hpo-7_pd Subfamily hpo-7 485-663 7e-12 39.8 In-house 44-228 (263) alignment
Range on Protein: 485-663
Range on HMM: 44-228/263.0
KNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYYWPKSPSDPAVTvpGGLRIENFGVYQapDPLFRVTHLRL-IGPDREERHVEHWQ--G--DVNNSS
 .|.| |.... | .   .|||.  .|   |.|. |.|    .  .     . .    | .  |.| .  .|   .|  .. . |.|..  |  ..|.  
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkl..anvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpe

NMYSPLNILRLLRNAsKPVVIHDHLGVSRAACLVAAEIAIC----SLLRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFR
.. . ||||.. ||  |..|.|   |. |.|  . ||..      ||   .| .    . .. ||..|. .|.||||  |   .|  |. 
lareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl

subfamily_CG42327_pd Subfamily CG42327 446-530 1.2e-10 35.6 In-house 42-129 (319) alignment
Range on Protein: 446-530
Range on HMM: 42-129/319.0
STRIALQFPRGQYLGDFIHANRISGK-PLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPE--RCEYYWPKSPSDPAVTV
 ||. ||    .    ...|. . |     | .| .|......  ||||.||.     || ||.  |    .|  |.| . . .   .
etrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 423-521 3.5e-10 33.8 In-house 59-155 (349) alignment
Range on Protein: 423-521
Range on HMM: 59-155/349.0
PFTHSASDNnqEKCRNPRVHCKDSTRIALqfprGQYLGDFIHANRISGKPLFN--EFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEP--ERCEYY
|. ||      .|  ..    | ||  .     .  | |.| || ..   .     .| ||||.  |||||....  ..|. .. |.. ||.  |.|. |
Pyehsrvkl..kkslksskvikastsesd....sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiy

WPK
| .
wqe

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 430-520 9e-10 32.4 In-house 49-139 (302) alignment
Range on Protein: 430-520
Range on HMM: 49-139/302.0
DNNQEKCRNPRVHCKDSTRIALQFPRgqylGDFIHANRISGKPLFNEFIMTQAPMKNTV---DDFWRMVWQEEVPYIVMLTSRKEPER-CEYYWP
 .| .|.... | . ||... |.        ....| ...   | .. |..| | ....   ..|||||.||..  .|.|   .| ..  . ..|
kknlkknqsedvpildsnlvkleaep....dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfp

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 476-525 2.3e-08 28.4 In-house 6-57 (199) alignment
Range on Protein: 476-525
Range on HMM: 6-57/199.0
EFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE-PE-RCEYYWPKSPSD
 .| || |...|. |||.|||.    .|||.   .   |    .||| . | 
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesg

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 476-525 2.3e-08 28.5 In-house 5-56 (198) alignment
Range on Protein: 476-525
Range on HMM: 5-56/198.0
EFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE-PE-RCEYYWPKSPSD
 .| || |...|. |||.|||.    .|||.   .   |    .||| . | 
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesg

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 424-519 4e-08 27.1 In-house 29-129 (347) alignment
Range on Protein: 424-519
Range on HMM: 29-129/347.0
FTHSASDNNQEKCRNPRVHCKDSTRIALQfP------RGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPERCEY
|| .  ... .| |   |. .|.||. |  |      | .    .| |  |      .|.|.|| |. .|| |||.||    |  .| .   .. |  | 
ftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee

YW
. 
fa

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 473-521 5e-08 26.7 In-house 234-281 (440) alignment
Range on Protein: 473-521
Range on HMM: 234-281/440.0
LFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEpERCEYYWPK
  | || || |.  || ||||.| . ..  |.||   ..   |  ||| 
kknafiatqmpldstvldfwrlvhdyristiimlnqlnd.ktcsiywpv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 588-666 6.8e-08 26.3 In-house 213-289 (302) alignment
Range on Protein: 588-666
Range on HMM: 213-289/302.0
LLRNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGptYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFFRDVI
.  .|....||  . |. ||. .... .|...| .|   .  ..  |. .|. || ....  ||..... ......  .
kkikadentvivSknGaGRagafltlavaveklqkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 430-522 9.5e-08 25.9 In-house 94-181 (244) alignment
Range on Protein: 430-522
Range on HMM: 94-181/244.0
DNNQEKCRNPRVHCKDSTRIALQfpRGQYLGDFIHANRISGKPLFNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPercEYYWPKS
 ||  | |.      |  |. |   .|     .| |  .       |.|.|| |. .|  |||.|. .  |  .|.| | .|    . ||| |
pnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee...deywpds

subfamily_PTPN14_pd Subfamily PTPN14 590-661 1e-06 23.0 In-house 226-295 (300) alignment
Range on Protein: 590-661
Range on HMM: 226-295/300.0
RNASKPVVIHDHLGVSRAACLVAAEIAICSLLRGPtyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFF
.... ||..|   || |.  |. ... | .|  .   .  ...... ||..| . ..|  || ||....  .
keskPPvlvhCsaGvGrtGvlilsdlliatlehne..eidikkvlarLreqrmllvqtlaqYkfvYkvliky

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 475-522 2e-06 22.1 In-house 28-72 (130) alignment
Range on Protein: 475-522
Range on HMM: 28-72/130.0
NEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKEPercEYYWPKS
.|...||.|. .|  |||.|. .  |  .|.| | .|    . ||| |
aeylltqhpladtsmdfwkmmleryvnvlvvlgsveee...deywpds

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 435-511 3.1e-06 21.1 In-house 46-118 (312) alignment
Range on Protein: 435-511
Range on HMM: 46-118/312.0
KCRNPRVHCKDSTRIALQFPRGQYlgdfIHAN--RISGKPlfNEFIMTQAPMKNTVDDFWRMVWQEEVPYIVMLTSRKE
  | | . | |  |..|      |    ||||  .|  ||  . |. ||.|..||.  ||...       |..|..  |
lnrypniqcwdrgrftlagdenfy....ihanfvkictkp..erfvctqgplentcthfwqlalslgstsiillcgfve

subfamily_CG42327_pd Subfamily CG42327 590-661 4.3e-06 20.6 In-house 244-314 (319) alignment
Range on Protein: 590-661
Range on HMM: 244-314/319.0
RNASKPVVIHDHLGVSRAACLVAAEIAICSLlRGPTYKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFF
|.   |.|.|   || |.  ..|..||| ||   .     . . |...|. |  .. |  || |... .  .
resqGPlvvhcsdGvGrtGlviasdiairsl.eeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 583-662 6.5e-06 20.1 In-house 199-276 (312) alignment
Range on Protein: 583-662
Range on HMM: 199-276/312.0
LNILRLLRNASKPVVIHDHLGVSRAACLVAAEIAICSlLRGPTyKYPVQRAVQFLRQRRPFSIETPMQYIFVHRLVAFFF
| .|  ...  |||. |   || |.  |.  |  |.. || |  |  |. .  .||. |  |...  ||... | |  |.
lrllsavkkdkkpviahcsagvgrtgtlaliesmiaa.lrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 416-506 6.7e-06 19.8 In-house 18-107 (332) alignment
Range on Protein: 416-506
Range on HMM: 18-107/332.0
ENSVNHIPFTHSASDNNQEKCRNPRVHCKDSTRIALQFPRGQylGDFIHANRISGKPLFNEFIMTQAPMKNTVD-DFWRMVWQEEVPYIVML
  |    | |.    || .  | |...| | .|. |    |.   ||  |. . |    . .|..|||...  .  ||||| . .   |...
htsamtypntydkflnnmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf

PTPc_motif_SM00404 583-652 7.4e-06 20.9 In-house 70-131 (140) alignment
Range on Protein: 583-652
Range on HMM: 70-131/140.0
LNILRLLRNASKPVVIHDHLGVSRAACLVAAEIaicslLRgpTYKYPVQRAVQFLRQRRpFSIETPMQYI
|....  ..  . |..|  .|||| |.|..|..     .|  .... .. |..|...||  .|.  ....
ldfienaekkggkvlVHCqaGvSRSatliiaYl.....mr..yrqlslaeayefvkerR.piispnlnfv