Gene F10G8.1 in Caenorhabditis elegans

Synonym: CELE_F10G8.1, F10G8.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP057_AA protein Get Run
CeleP057_AA_38-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 33-338 1.7e-199 655.9 In-house 1-305 (305) alignment
Range on Protein: 33-338
Range on HMM: 1-305/305.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
|.|||||||||||.|||||.|.|||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt

CADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG
||||||||.|||||.||||||.||||||||.|||.||..||..|.|.|||||||.|||||..||.||||.||.|..||||||||.||.|||||.||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESgVQE
|||||.|.|||||.||||||||||||||||||||||||||||.|||||||||.|..|||.||.|||||||||||||||||||||||||||||.||. |.|
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee.vke

AYDAFL
||.|||
aykafl

0050432 (Phosphotyrosine protein) phosphatases II 32-323 8.1e-80 263.7 In-house 22-303 (308) alignment
Range on Protein: 32-323
Range on HMM: 22-303/308.0
VERKQQKKQILKFVQRtlEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLegPWPHEYIHANYVATP--TNPKRFICTQAPL
.  |.  ...||....   . ...|..||  .... . .......  .   ||||||. ..|..||||  . .. ||.|.|| ..   .|..||.||.||
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPl

EKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG-DVMDFDeggqKISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWND
..|..||| |... .|..| ||... |.| .||..|.|.. | ... ..    |..|.. |  .       ....| ... ..   ....|. ||.|. .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfhytn

WPDRGVPAADMAVLELLENARPS--KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
||| |||    ..|..|| .| |  .||||||||||.|||| ...|.....|| ... .|  .... |. |||....||  ||||.....| |...|.
WpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd.vfeavkklReqRpgmvqtpeqylflyralleylklkl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-322 1.4e-79 262.3 In-house 5-280 (307) alignment
Range on Protein: 43-322
Range on HMM: 5-280/307.0
KFVQRTLEKMPQGLRAEFVGMRRFNDF-EKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGP-WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
 .|||||.|  | |. ||  . . .     ..||.  ..  ||||.|| | |..|. .. .    .||||||. . ..||.|||.| |||.|  .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama

YQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTYSFrADAKANVTATEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAV
 |.||| . |||. .| .  || .|.| ..|. . | | .. |||.   . . .   .   |||. ...    ..|.|  .|. |..|||||||  ... 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklap.dedlinvttlkvdw...aqksrtiqhlqwenwpdrgvpqinlta

LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
..|||  |  . |.|||||||.||.|..| . ...|...||.   | .|.. .. .||. .|||.||||..|.|.|.|| ..
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflel

0040438 (Phosphotyrosine protein) phosphatases II 39-325 3.7e-79 261.6 In-house 3-281 (317) alignment
Range on Protein: 39-325
Range on HMM: 3-281/317.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCAD
...|..... | .. ..|. ||  .....    .. ..  .  .||||.|. ..|..||||  . .   . ||.|.|| .|  ...||.||.||..|..|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|..| ||... |.| .||..|.|.  |... ...    ..|.. | ..       .|..| ... .|.  ....|. ||.|. .||| |||
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygd....ftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvp

AADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFrKKKLM
     .|..|| .| .    .||..||||||.||||..........||  .. . | |... .. |||....|| .|| |.....|.|. |.||.
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleyl.krklt

0036941 (Phosphotyrosine protein) phosphatases II 53-324 3.1e-77 255.1 In-house 12-282 (297) alignment
Range on Protein: 53-324
Range on HMM: 12-282/297.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|. ||  . ..    ......  .   ||||||. ..|..|||| .. .. ||.|.|| ..  ...||.||.||..|..||| |... .|. | ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NFLEKGAKKCFEYFPSKKGDVMDFdeggQKISVKCESSVTYsfradAKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP--
.. |.| .||..|.|...|... .     ...|.. |  ..      ....| ... ..   ....|. ||.|. .||| |||     .|...| .|   
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA--GQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKL
    |.||..||||||.||.|..........||     .   |  ... |. |||....||  ||.|.....|....||..
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

0051299 (Phosphotyrosine protein) phosphatases II 37-319 5.4e-77 254.4 In-house 6-286 (288) alignment
Range on Protein: 37-319
Range on HMM: 6-286/288.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTC
. ...||.|...| . . ||..||  .....   ...|..  .   ||||.|. ..|..||||  .    .. ||.|.|. .. ....||.||.||..|.
sveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

ADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-----PGEKTRKTTHYHWNDW
.||| |... .|..| ||... |.| .||. |.|.  |... ...    |.|.. | ..       ....| ... ..      .....|. ||.|. .|
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnw

PDRGVPAADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|| |||    ..|..|. .| .    .||.|||||||.|||| ...|.....||.... .|  .... ...|||....||  ||.||....| |.
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.vleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 37-322 4.3e-76 250.5 In-house 7-292 (305) alignment
Range on Protein: 37-322
Range on HMM: 7-292/305.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMK-AFKEAQE----AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNP-KRFICTQAPLE
 .  . .||.|.|.   . || || |. ..   .  . ||.  |       ||||.|| | |.. |||. | | .|||||||  |  | |||||.| ||.
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld

KTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGgqkISVKcESSVTYSFRADAKANVTATEIVIEgpGEKTRKTTHYHWNDWPD
.|  .||.|  |.||| | |||. .| |  || .|.|  .|. ...  |   | |. . | .  .  ||. ..|  ..     |...    | .|..|||
qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg...ivve.nvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpd

RGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|||| . .. ||||   | || ||||||||||||||..| .|||....   .      ...  . .||  |||.| ||||.|.|.|||| .|
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

0046845 (Phosphotyrosine protein) phosphatases II 55-323 6e-76 250.8 In-house 1-278 (284) alignment
Range on Protein: 55-323
Range on HMM: 1-278/284.0
GLRAEFVGMRRFNDFE--KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATP-----TNPKRFICTQAPLEKTCADFWYMCYQD
||..||  ..... .   ......  .   ||||||. ..|..||||  . .    ..||.|.|| ..      ..|.||.||.||..|..||| |... 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVEYIFMLCNFLEKGAKKCFEYFPSKkGDVMDFdeggQKISVKCESSVTysfraDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLEL
.|..| ||... |.| .||. |.|.. |.|. .     ...|.. |  .     .    |.  |.. .|.....|. ||.|. .|||.|||.    .||.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef

LENARPS------KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQI--IDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
|. .| .      .||||||||||.|||| ...|.....|| ....    | .... ...|||....|| .||.||....|.|...|.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl

DSPc_SM00195 59-319 2.7e-75 248.4 In-house 5-262 (263) alignment
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
||  ... .  ....  .. ..  |||||.. . |..||||. .    ...||.|||. .....|..|.||.||..|..||| |... ||..| ||... 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYSfradakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|.    |||||. .  ...      .... ... ..  | |.|||.|.|....|||.|||   . |||||. .. |    
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ...  .| ..|. .. .|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 59-319 2.7e-75 248.4 In-house 5-262 (263) alignment
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
||  ... .  ....  .. ..  |||||.. . |..||||. .    ...||.|||. .....|..|.||.||..|..||| |... ||..| ||... 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYSfradakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|.    |||||. .  ...      .... ... ..  | |.|||.|.|....|||.|||   . |||||. .. |    
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ...  .| ..|. .. .|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi

0047943 (Phosphotyrosine protein) phosphatases II 53-319 3.7e-74 244.9 In-house 11-272 (273) alignment
Range on Protein: 53-319
Range on HMM: 11-272/273.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|..||  .... .  ......  .   ||||||. ..|..|||| |. .. ||.|.|| ..  ...||.||.||..|..||| |... .|..| ||.
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

NFLEKGAKKCFEYFPSKKGD-VMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-
.. |.| .||. |.|.. |. .. ...    ..|.. |  |       |...| ... ..    ...|. ||.|. .||| |||.    .||..| .|  
elvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
     |.||.|||||||.||||....|....||| ... .|  .... ....|| ...||  ||.|.....|.|.
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 37-321 5.6e-74 244.9 In-house 10-306 (307) alignment
Range on Protein: 37-321
Range on HMM: 10-306/307.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFND--FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYV--------ATPTNPKRF
. ...|..|...| . ..||..||  ......    ......  .   ||||||. ..|..||||  . .    . ||.|.||         .. ....|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG--PGEKTRKT
|.||.||..|..||| |... .|..| ||... |.| .||..|.|.. |... ...    . |.. |  .       ....| . . ..   . ...|. 
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrtv

THYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKICEQRNNSIQTDAQYLFVH
||.|. .||| |||     .|...| .|       ..||..||||||.||||..... ....|| .....   | .... .. ||| ...|.  || |..
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

QVILNYFRK
...| ...|
eallelllk

Y_phosphatase Protein-tyrosine phosphatase 82-317 7.2e-71 233.7 Pfam-A 3-235 (235) alignment
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEgg
 ||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..  ||| .|| .|.|..... . ...  
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..

qkISVKCEssvTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
  |.|...   . . ..... ... .|.  ..  ...|.....|...|||.|||.   ..|.|... . ||    ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |..   |  .|. .. .||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 82-317 7.2e-71 233.7 In-house 3-235 (235) alignment
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEgg
 ||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..  ||| .|| .|.|..... . ...  
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..

qkISVKCEssvTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
  |.|...   . . ..... ... .|.  ..  ...|.....|...|||.|||.   ..|.|... . ||    ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |..   |  .|. .. .||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

0043336 (Phosphotyrosine protein) phosphatases II 39-319 1.3e-70 233.4 In-house 5-277 (278) alignment
Range on Protein: 39-319
Range on HMM: 5-277/278.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDfEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCAD
|..||.... | .....|..||  ...|.  . .. ..  .   ||||||. ..|..||||.      .. ||.|.|| ..  |..||.||.||..|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPskkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|. | ||... |.| .||..|.|   |... ...    ..|.. .  .       ....| . . ..     ..|. ||||. .||| |||
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvp

AADMAVLELLENARP----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
     .|..|. .|     |.||..||||||.|||| ...|.....||  .. .|  |... .. ||| ...||. || |.....| |.
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl

0039614 (Phosphotyrosine protein) phosphatases II 54-322 2.9e-69 229.1 In-house 32-292 (297) alignment
Range on Protein: 54-322
Range on HMM: 32-292/297.0
QGLRAEFVGMRRFNDfEkMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYI
..|..||  . .... . .. ..  .   ||||||. ..|..|||| ..      . ||.|.|| ..   ...||.||.||..|..||| |... .|..|
tllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

FMLCNFLEKGAkKCFEYFPSKKGdvmdfD--EggqkISVKCESSVTysfradaKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
 ||... |.|  ||..|.|.. |        .    ..|.. .  .       ....| ... ..  ....|. ||... .||| |||     .||.|| 
vmLtklvelgr.kcaqywpeegg.....tygd....ftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflel

ARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
.|       ..||..||||||.||||..... ....||  .. .|  .... .. |||....||. || |.....| ....|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk

0040439 (Phosphotyrosine protein) phosphatases II 80-321 8.3e-66 217.4 In-house 11-248 (249) alignment
Range on Protein: 80-321
Range on HMM: 11-248/249.0
EAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDF
   ||||.|. ..|..||||   .| ... ||.|.|. ..  ..|||.||.||..|..||| |... ....| ||... |.| .||..|.|.  |... .
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley

deggQKISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVV
     ...|.. |  .       |...| ... ..     ..|. .|... |||| |||     .|...| .|       ..||..||||||.|||| ..
....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

MLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.. ....||   . .|  | .. .. .||....|.. || |.....| ...|
aaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 35-325 4.2e-65 214.2 In-house 8-289 (290) alignment
Range on Protein: 35-325
Range on HMM: 8-289/290.0
KQQKKQILKFVQRTLEKMPQGLRAEFVG-MRRF--NDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATpTNPkRFICTQAPLEK
  | . . ||   . .| ...|  |..  .. .   .. . | | .  |  ||||||| | |  || |.   . .|.|||||   ...  || || .|..
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG.lka.mfiltqGalkd

TCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESSVTysfrADAKANVTaTEIVIEGPGEKTRKTTHYHWNDWPDR
|  |.| |  |.|| .| |||. .|.|  || .|.| |.|.|. | |    |.| |  . .     ||.     |  | .    |  |  |..   |||.
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe....itvlcseedd....kdaniikk.tlsvrdkdsGkehklkhlkikswpdk

GVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLM
 |. ...|.| .|   |   ||.||||||||||||. | .|  .. || |. .|  . .   . . | ||.| | ||| . ...|.. .. | .
svalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlld.lvralrnsrlnsvqvdiqylalveilldlGkdfkyi

0045098 (Phosphotyrosine protein) phosphatases II 78-322 3.6e-63 208.9 In-house 31-275 (278) alignment
Range on Protein: 78-322
Range on HMM: 31-275/278.0
AQEAGKNRYKDVGCLDNNRVKlegpwphEYIHANYVATPtnPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFD
   . ||||||. ..|..|||       .||.|.|. ..  ||.||.||.||..|.|||| |... ....| ||....|.| .||..|.|.  |... ..
lgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltyg

EggqkISVKCESSVTYsfRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--MAVLELLENARP-----------------SKGPIVVHC
.    ..|...|  ..      .   . | . .| .. ..|. ||.|.  ||| |||  .  . .|||||  |                  |.||..|||
d....ftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGSVVMLEYIMDQLlaGQIIDdGEKILVKICEQRNN-SIQTDAQYLFVHQVILNYFRKK
|||.|||| .|.. .....|  .. .|  .... .. .||.. ..|.  || |.....| .....
saGvgRtGtlvaaylmlell..eggvd.lleavkelrsqRpglavqnleqyrflyefllelllrg

0042113 (Phosphotyrosine protein) phosphatases II 79-320 6.2e-63 207.8 In-house 8-244 (245) alignment
Range on Protein: 79-320
Range on HMM: 8-244/245.0
QEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMD
    ||||.|. ..|..||||  . .   . ||.|.|| ..  ...||.||.||..|..||| |... ....|.||... |.| .||..|.|.  |... 
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt

FDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
...    ..|.. |  .       ....| ... ..  .  ..|. .|||. .||| |||  .  .|..|| .|      |.||..||||||.|||| ..
ygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

MLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. ....|| . . ..  |... .. .|| ...||. || |.....|....
aaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallellk

subfamily_PTPRD_pd Subfamily PTPRD 41-321 8.4e-60 198.0 In-house 10-283 (564) alignment
Range on Protein: 41-321
Range on HMM: 10-283/564.0
ILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAqEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFW
. ..|..   .  . .  |.  ... . |.. .| |.|    ||||...   |..||.|   ||    .|| |... . ...| .| ||.||..|..|||
lkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW

YMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGdVMDFdeggQKISVKCESSVTYSFRADAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPAAD
 |... ... | || .  ||| .|| .|.|.| |    .    ... |. |......     . ... ..       ...|. ...|. .|||.|||   
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety....geltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgvpesa

MAVLELLENAR----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
 ..|.|... |    | .||||||||||.||||  . ........ . . .|   ... .. .|||  .||  || |.|..||..  .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDi.yqyvkalrkqRnamVqteeQYiFiheailealac

0037934 (Phosphotyrosine protein) phosphatases II 75-319 3e-59 195.8 In-house 5-242 (243) alignment
Range on Protein: 75-319
Range on HMM: 5-242/243.0
FKEAQEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPtnpKRFICTQAPLEKTCAD----FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPskk
..  .   ||||.|. ..|..||||||   . ||.||..  .   .|.|.||.||..|..|    || |... ....| ||... |.|..||..|.|   
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

GDVmDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG--PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR------------PSKGPIVV
|.|  ...    ..|.. |. .       ....| .....|   ... ||  .|||.  ||| |||     .|..|. .|            .|.||..|
gev.tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV

HCSAGIGRTGSVVMLEYIMDQLlaGqiiDDGEKILVKICEQRNN-SIQTDAQYLFVHQVILNYF
|||||.|||| .... .....|  |    | |... .. |||.. ..||  || |.....| ..
HCsaGvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeallell

subfamily_PTPRB_pd Subfamily PTPRB 36-323 7.2e-59 194.2 In-house 7-289 (293) alignment
Range on Protein: 36-323
Range on HMM: 7-289/293.0
QQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
 ..... ..|... ..   ..  |.  .. ..  ...|| ..|... ||||...   |..||||   ..    .|| |||.   . |. || || || .|
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

CADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgdvmdfdeggQKISVKCESSVTYSFrADAKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRG
  ||| |....|.. | || . .||| .|| ||.|..           ..  .  . .||     . . . .  |. ||  ....||...||.  ||| |
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...........eepvlyGdikvtlva.eeeledwvirelkiek.ekeerkvrqyhftsWpdhg

VPAADMAVLELLENAR------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
|| .  ..|..... |       ||.|||||||||.||||  . |. .....   ...|    |.... |.||. .|| .||.|.||..|...|||.
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi.fgivaelReeRnllvqtekqYifihqcvldllrkke

subfamily_PTPN9_pd Subfamily PTPN9 40-324 1.3e-55 183.6 In-house 2-295 (297) alignment
Range on Protein: 40-324
Range on HMM: 2-295/297.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.| ..|.   ||  .||. |.. .|. .   ...|.|   .  ||||.|| |.|. ||.|.   .    .||.||.|    ..| || || ||.||. ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYsfrADAKanvtATEIVIE-GPGEKTRKTTHYHWNDWPDRGVPA
| | ....|  | |   ..|.|  || .|.|........|     ..||.  . ...    | |     . ..|.    |..|| ||.    ||| ||| 
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvsnveveee...edyk....vrvleiknvkteesrkvthfqflsWPdyGvPs

ADMAVLELLENAR-----------------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
. ...|..||..|                 ||. ||||||||||||||  . |.. ...|   . .|   . . .. .||  ||||. || | .. .|.|
saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvv.etvkllrtqrafsiqtpeqyefcylavley

FRKKKL
  ..| 
alelka

subfamily_PTPN12_pd Subfamily PTPN12 63-322 1.3e-55 183.3 In-house 24-280 (290) alignment
Range on Protein: 63-322
Range on HMM: 24-280/290.0
MRRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHE---YIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGA
... . ... .. .. ..  ||||||.   |..||.|.    .|   || ||..  .......| .|.|| ||  ||| | .. .|| . |.|. .| | 
ykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

KKCFEYFPSKKGDVMDFDEggQKISVKCESSVTYSFRADAkANVTATeiviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----KGPIV
|||  |.|..... . |.|   ..... |  |.  |   .  .|.|         ...|| . .|...|||.|||..   .|||.|..|      . |.|
kkCerYWpeegeeelefge..fevtleeekavdddflirt.Lkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlv

VHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDG--EKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
||||||.|||| .. ..|. ..| |..| ..    ...... .||.  .||  || .|.. ......|.
vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 71-324 2.2e-55 182.7 In-house 36-276 (288) alignment
Range on Protein: 71-324
Range on HMM: 36-276/288.0
KMKAFkeAQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKK
 ...|   ... ..||... . |  ||||.   |. ||.|| |..  ...|.||.||||. |   .| |  .  |||| |||..|||| .|  ||||||.
iidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GDVMDFDEGgqkisvkceSSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
|. . .             .|.   ||| .  |. . . |. .||..    . |...|.| |||   .. | |||  .  . |||||.|||.|||| ...
Gekarigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlil

LEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKL
   ....|     .   ...| |  |.| ..|||  |||.||...|...  || 
ilialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvleelllkky

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 43-331 1.2e-53 177.0 In-house 10-285 (288) alignment
Range on Protein: 43-331
Range on HMM: 10-285/288.0
KFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
. |...  .  .|.  |.  .  ..  .. .| ..|. | ||||...  .| .||||..       .|| |.|..   . |..|.||.|| .|  ||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

CYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmDFdeGgqkisvkcesSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMA
 |..|.. | || ...|.| .|| ||.|...  .  .  |          |||   . . . . . .. .. .  .. ...|.|..  ||| |||.. . 
vyenktstivmltelveggktkCeeYWPdadkpk.ny..G..........svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskap

VLELL---ENARPSK-GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILnyfrkkKLMDESGVQ
.||||   ..| ... |||.||||||.||||  . |. ..|.. . . ||  . .. |. .||.. .||  || |...|.|      .|..| ||.
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevll......slieedgva

subfamily_PTPN3_pd Subfamily PTPN3 59-321 5.5e-53 174.7 In-house 20-277 (280) alignment
Range on Protein: 59-321
Range on HMM: 20-277/280.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPhEYIHANYVATPTNP----KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
.|  . | .   ...| . .... ||||.|.   |. ||||.     .|| ||||    .     .|.| || ||.||..|||.| ...|.. | || . 
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

LEKGAKKCFEYFPSkKGDVMDFdeGgqKISVKCESSvtysfraDAKANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK--
.|.| .|| .|.|. ..| ...  |  ..|||||..       |.. ..   |.|..    .. || ..  . .||| |||     .||..|. |  .  
verGrvkChqyWPe.tedeley..g..efsvkceke.......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg

--GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
   |.|||||||||||| ...||  .  . | . .    .|. .. .|| . .|| .|| || . ||. ...
keePvvvhCsaGigrtGvlilletalalieaaepvyp.ldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 53-320 3.2e-52 172.6 In-house 21-284 (305) alignment
Range on Protein: 53-320
Range on HMM: 21-284/305.0
PQGLRAEFVGMRRFNDfeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
 .|| |..  . . ..  ...  |. ... |||.|..  ||..|..|        ..|| |.|| .  . |..| .|.||..| ||||.. .. ||. | 
dkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLCNFLEKGAKKCFEYFPSKKGDVMDFdeggQKISVKCESSVTYSFRADAKANVTATEIviegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN---
||..  | | .||  |.| .|.....|    ...||. .|. |.|     | ...  .       ...|  ..|.  |||| |||    ..|.|...   
mltklveggkdkCrqYWpesktekkef....gefsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk

-ARPSKG-PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
  . .|| |..||||||.||||  ....  ...| . ...|   ..| .. ..| . .|| .|| |.|... ..  
dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdv.fevlkqlRskrmkmvqtldqYvflhdaldelit

subfamily_PTPN6_pd Subfamily PTPN6 38-325 8.5e-52 171.0 In-house 10-303 (306) alignment
Range on Protein: 38-325
Range on HMM: 10-303/306.0
KKQILKFVQRTLEKMPQGLRAEFVGMRRF---NDFEKMKAFKeAQEAGKNRYKDVGCLDNNRVKL-EGPWPH-EYIHANYVA--TPTNPKRFICTQAPLE
.... .. . . ..  .|.  ||  ...    . ...... | .. . ||||| .   |..||.| |   |  .|| |||.   .... |..| ||  ||
eqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

KTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMdfdEGGQKISVKCE-SSVTYSFRADAKANVtateivieGPGEKTRKTTHYHWNDWP
.| .||| | .|.. . | |. . .|.| .||  |.|... . .    |  ...   | |  .| .|    ...          ....|.  .||...||
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskk........kkkkeerevfqyhfksWP

DRGVPAADMAVLELLENAR--------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
| |||.   |||..||. .         ..|||||||||||||||...... .....    .    | .|.  .. |||.  .||..|| ||...| .| 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

RKKKLM
..|| .
etkkkl

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 81-312 2.5e-50 166.0 In-house 51-274 (301) alignment
Range on Protein: 81-312
Range on HMM: 51-274/301.0
AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFdeGG
  |.||. | |  .  |..        ||||.. |. .|.|||.||.||..|. ||| |. | .|| | ||....||  .|| ||.|.| .. .|   | 
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi..gr

QKISVKCESSVTYSFRADAKANVTATEIVIegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA
 || .| . ..        . .|. .   .     .||  ||| ...|.||||| . . . .|.| .. |. ||||||||||||. . .  ||.  ...|
fkikiknkelilnkkiskrtlevedstgkf.....atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea

GQIIDDGEkILVKICEQRNNSIQTDAQYLFVH
 . |.  |  | .. |.| |..||  |  .. 
dptielte.alkhlrehrwngvqtnsqlywmt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 33-319 3.6e-50 165.9 In-house 6-290 (298) alignment
Range on Protein: 33-319
Range on HMM: 6-290/298.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFND---FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQ
| .. |... |... . .|   |. .||  ... ..    |.... .. .   |||| |.  ||  || ||        .|| | .. . .. . || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

APLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDfdeggqKISVkcessvtYSFRADAKANVTATEIVIE-GPGEKTRKTTHYHW
|||..| .||| |  ..... | || |  |..  |. .|.|... .  .      .|.|          . . .|... ... ..    ||.|.  . |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg......eitv.......sllskeefadlivrklkvskkkeekerevrqlhf

NDWPDRGVPAADMAVLELLENARPS---KG--PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
  |||.|||.   .||.||.. | |    |  |..|.||||.||.|. . .. ..... . | .|   ...  . ..| ...|| .|| |.....|...
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDv.fqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 44-322 3.9e-50 165.5 In-house 5-279 (281) alignment
Range on Protein: 44-322
Range on HMM: 5-279/281.0
FVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
 .... ..  .|.  |. ...  .  .  .| |. .   ||||...   |. |||.   |     .|| ||.|.. ...|..| ||.|. .....|| | 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

YQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdvmdfdeggqkiSVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAV
.. ||. | |. . .|.|  ||  |.| ..             ..|    .  | .. .||.    .. .|  . .||. .. ..  ||| ||||  ...
weqkvsaivmvtreieagklkChrYWPddns............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkel

LELLENA----RP-SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
||  ..     .. .| |.|.|||||.||||. . |. ..... | .   | . .. .. ..||  .|| .|| ||....|... |.
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke

subfamily_PTPN23_pd Subfamily PTPN23 81-321 7.3e-50 164.4 In-house 44-282 (288) alignment
Range on Protein: 81-321
Range on HMM: 44-282/288.0
AGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVA--TPTNPKrFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDE
. |||..|.   |.|||||.|    .|| | .|   .|. |. ||.|||||..| .||| | |..|.. | || .  |.| .|. .|.|..||. . |..
seknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd

ggqkISVKCESSVTYSfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--------RPSKGPIVVHCSAGIGRTGSVVM
    .|| ..|  . .        |  . ..   . ..... .| ... ||. ||||.   .|..|...        |.|| |.|||||||.|||| . .
....lsvtlksvrete......thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal

LEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.  .. .| .|... |  ... ...||| ...|. .|. |. ...|.. |.
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 51-321 8e-50 164.7 In-house 17-282 (318) alignment
Range on Protein: 51-321
Range on HMM: 17-282/318.0
KMPQGLRAEFVGM-RRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVE
.    | .|.  . |  . . ..|.  |   . |||| ..   |. ||||.   |    .|| |||.   .. | .| .|||| .|. ||| | .. .  
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

YIFMLCNFLEKGAKKCFEYFPSKKGDVMDfdeggqKISVKCESSVTYSFRADAKANVTATEIviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
 | || .  |.| .|.  |.|||.   ..      |. |. ...|..|     . .|| ||       |..|.   ||. .|||.|||.  . .|.|. .
vivmltqeeergkakvhryWPskgsrsyg......klvvelkeevelsdyvlrefkvtrtee......eesrqvrqyhytsWpdegvpesgaslldlvrq

A-----RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.     ....||||||||||.||||  .... ..... | ...|   ..  .. ||||  .||. || |...|.|..   
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvllealas

subfamily_PTPRG_pd Subfamily PTPRG 54-343 8.5e-50 164.5 In-house 19-314 (563) alignment
Range on Protein: 54-343
Range on HMM: 19-314/563.0
QGLRAEFV--GMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEY
.|. .||    ..  ..  .... .. ..  |||| ..   |. ||||..       ..|| |||.      | || || ||..|. ||| | .. .|. 
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IFMLCNFLEKGAKKCFEYFPSkkGDVMDFDeggqKISVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE--
| |. |. |.|..||. |.|.   ......    ...|. ... . .  .  .  .  ...  .   .. .. ..||. .||| |||   . ||   .  
ivmitnlvergrrkcdvYWPk..desetyg....alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

-NARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK--KLMDEsGVQE--AYDAFLE
  |...  ||||||||||.||||  ..|. .. |. . ....   ..| .|  |||. .||  ||.|.|...|.  . |  .|..|  |.|      .||
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavn.vfgflkhiraqRnflvqteEqYiflhdalleaiasketellae.qveelknctpyle

QYKK
|  |
qqyk

subfamily_Ptp69D_pd Subfamily Ptp69D 54-322 9.9e-50 164.4 In-house 22-289 (307) alignment
Range on Protein: 54-322
Range on HMM: 22-289/307.0
QGLRAEFVGMRRFnDFEKMKAFKEAQ-EAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.||  |.  . .   ..|   . | .  | ||||.|.   |..||||.   |    .|| |... .  . |.||. |.|.| |  ||| |  . .|. | 
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLCNFLEKGAKKCFEYFPSKkgDVMDFDeggqKISVKCESSVTYSFRADAKANVTATEIViEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--
|| |  ||  |||  |.|    | . ..    .| ||. |. . |  .  . .|. ..    |  |..|| . ||.. |.|  || .  ..|.|.|..  
mlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkee.sgevedsrkvvqyhytgWkDskvPevargllklieqvre

--RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
  . ...||||||||| ||.| .| |. ...|| | . .|  | .  .. .|||  .|  .|| |... .|.|  . 
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife.tvkdLrsqRnllvqsleqYvflyralldyssyg

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 54-321 1e-49 164.1 In-house 5-270 (274) alignment
Range on Protein: 54-321
Range on HMM: 5-270/274.0
QGLRAEFVGMRRFNDFEKMKAFKeaqEAGKNRYKDVGCLDNNRVKLEGPWPH----EYIHANYVATPT-NPKRFICTQAPLEKTCADFWYMCYQDKVEYI
. |..||. .    | |... |.   .. |||||..   .| || ||   ..    .|| |||.  .  . | .. || || .| |||| | ||..|. |
kdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

FMLCNFLEKGAKKCFEYFPSKKGdvMDFDEGGQKISvkcessvTYSFRADAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENAR
 || .. |.  .|| .||| ...  .. .|  ....            .  . . . ...|..   . .|. .|| . ||||. .|    ..|.|... .
vmltklkeaneqkCavyfPdaed..yeiserygdve.......ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleve

P-------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
          .|.||||||||||||  .  .  . || . ...|   || ...  .|   .||. || ..|...  | ..
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 45-321 1.1e-49 164.2 In-house 14-285 (319) alignment
Range on Protein: 45-321
Range on HMM: 14-285/319.0
VQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCY
...  ..  ..|. ||  ..  ... ...  .. .   ||||...   |. ||.|   .|    .|| |... .  . ..|| ||||||.|  ||| | .
lkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

QDKVEYIFMLCNFLEKGAKKCFEYFPSKKgdvmdFDEGGQkISVKCESSvtysfraDAKANVTATEIVIEGPGEK--TRKTTHYHWNDWPDRGVPAADMA
....  . ||..  ||.  |. .|.|...     | |.|. . |. |.        . ....   .. ..   ..  ||. .|.....||| .||   ..
eeessivvmltklveklkvklkkywpeen.....feeyGr.livtleee.......eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

VLELLENAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.|.||.. |     ...||||||||||.||||. ..|. .....   ...|   ..  ..  |||  .|. .|| |.....|..   
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 74-338 1.8e-49 163.0 In-house 48-308 (310) alignment
Range on Protein: 74-338
Range on HMM: 48-308/310.0
AFKeaQEAGKNRYKDVGCLDNNRVKLEG--PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkG
|.|  ..  |||| || |||. ||||.      ..||||||| |    . |||.| ||..|  ||| | .|.. | |..||.  |.|  ||  |.||  |
ayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.g

dVMDfDEGGQKISVKCESSVTYSFRADAKANVTATEIVIEGPGE-KTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
 | .   |  ...  .|||  .     | . |     | | | . |  . .  .| .|||||||      .     |.  .|| |||||||..|.. || 
.vte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvva

LEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESGVQeAYDAFL
|.. .|.|  |. .|  |..  ..  .|   |||. |||....| . . | .. . |. .  . ||||
lklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifargetevaekill.ladafl

subfamily_PTPN1_pd Subfamily PTPN1 72-335 7.5e-49 161.0 In-house 24-285 (290) alignment
Range on Protein: 72-335
Range on HMM: 24-285/290.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
... |. .. ..|||.||   |  |.|||     .|| |. |  .   ...| || || .|.. || | ...|   . || ...||.  ||..|.|... 
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-DVMDFDEGGQKISV-KCESSVTYSFRADAKANvtateivieGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS------KGPIVVHCSAGIG
 . . ...   |. . . |.. .|  |     |            ..||. .|.|.  ||| ||| .  | |..| . | |      .|| |.|||||||
ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGSVVMLEYIMDQLLAGQI--IDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYfrKKKLMDESGVQEAYD
|.|...... .. .. . .     | .| |... ..|   |||  |  | .. ||.    |.....| ||. . 
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG..akvikgdssvqkrwk

0051429 (Phosphotyrosine protein) phosphatases II 106-342 1.6e-48 161.0 In-house 5-248 (272) alignment
Range on Protein: 106-342
Range on HMM: 5-248/272.0
EYIHANYVATPTN---PKRFICTQAPLEKTCADFWYMcYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDF-DEGGQKISVKCESSVTYSFRADAKA
 ||.|..| ....   |.|......||. |.||||.. .. .. .|..|..  |.|. ||. | |  .  .... |.. . |.. . .  ..|.      
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

NVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADmaVLELLENARPsKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDD-------GEKILVKI
 ..  ..... . ...|. .|.|. ||||.|||     .|||||  .  .||..||||||..||| ||.| ... .. . .|.||        |... ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

CEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESGVQEAYDAFLEQYK
 .|| ...||..||||.....|...|.   .... .. |.||. |.| 
raqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyG

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 76-321 1.1e-47 157.2 In-house 16-266 (270) alignment
Range on Protein: 76-321
Range on HMM: 16-266/270.0
KEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVA-TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
. |...  |||.|.    . ||.||        .|| ||||.    ..|..|....||. |  .|| | .. ||. | |. .. ||| |||  |.|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DVMDFDEGgqKISVkcessvtYSFRADAKANVTATEIVIEGPGEKTRKTtHYHWNDWPDRGVPAADM------AVLELLENAR-----PSKG-PIVVHCS
. ... .|  ||.|        .     .    .|.. .|  ||. | . |...|.|||.||| ..        .|..|.. |      .|. |..||||
ekvkledg..kikv.......lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
||.|||| ...|....  |   . . |  .|. .. ..| . .|.  || |.......| ..
aGvgRtGtlialDiavrlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_PTPN13_pd Subfamily PTPN13 57-319 2.3e-47 156.5 In-house 14-269 (273) alignment
Range on Protein: 57-319
Range on HMM: 14-269/273.0
RAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPheYIHANYVATPTNPKRF--ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
  ||  .| .   .. .  |....  ||||..|   |. ||||..  .  || |...  | . ...  | .| || .|..||| | .. |.| | |. . 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

LEKGAKKCFEYFPSKKGDVMDFDeggQKISVKCESSVTYSfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR---PSK
 |||  ||  |.|..|.. .      ... |. .  . ..      . |  .  |..   ...|. .| .. .||| |||.. . .|... . |    ..
kekgkvkchrywPesknkklkvs...nrlevellkvqkld......gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||||||||||||.|... .. ... .   . .|  ..|. |. |||.  .||. ||.||...||. .
gPivvhcsaGiGrsGtlitidvvlglierdkefd.vkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 71-321 5.3e-47 154.8 In-house 28-271 (281) alignment
Range on Protein: 71-321
Range on HMM: 28-271/281.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYF
   .|..  .  |||| .. |||  ||.|.   |     .||||||. .|   . .| || | ..| |||| | .|..   | |||.|||   .|| |||
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PSKKGDVMDFDeggqKISVKCESSVTysfradAKANVTaTEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTG
| .   ...||    |.||. | |         |. || | . .   || ||  ||. |..|||  || .   .|..| . |    | |.|||||.||.|
prnahcclqfd....klsvsyedstv......nkslvt.trlnlsyege.trlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsg

SVVMLEYIMDQLLAGQIIDDGEKILVKI-CEQRNNSIQTDAQYLFVHQVILNYFRK
... .|  .. . .   . | ..|. ..    |  |.||  ||... .|.|..   
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva

subfamily_PTPRA_pd Subfamily PTPRA 73-320 4.3e-46 152.3 In-house 51-296 (330) alignment
Range on Protein: 73-320
Range on HMM: 51-296/330.0
KAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
.. .. ..  |||. ..   | .|| |   ||    .|| | ..    . ..|| .| |.|.|  ||| | .. |   | || .. |.  .||  |.|..
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

kGDVmdfDEGGQKISVK-CESSVTYSFRadaKANVTatEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP----SKGPIVVHCSAGIGR
 | |     |  ...|. .. .| |. |   |  |.  ..  .   .|.|  . .|.. ||| |||.  . .|.||.. .     | ||||||||||.||
.Glv...tyGnirvevedetvlvdytvr...kflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

TGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFR
||. ..|. ..... | ...|  | .. ..  || . .||| || |...|.|.|. 
tGtfivldavlervkaerkvdvfe.fvkrlrlqrpqmvqtdeqyefiykvlleyyl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 40-344 4.9e-46 151.8 In-house 5-299 (312) alignment
Range on Protein: 40-344
Range on HMM: 5-299/312.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGPWpHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
 | |.    .   || |  |.  .       .  ||   ..   ||| .. | |  |  | |     |||||.|   |.|.||.|||.|||.||. || .
mikkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwql

CYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmDFDEggQkiSVKCESSVTYSFRADAKANVT--ATEIVIEGPGEKTrKTTHYHWNDWPDRGVPAAD
.       | .|| |.| |..|| .|     | | |...  .   |  |.         .| ..|     .|.   |... |  || |  ||| |.| . 
alslgstsiillcgfvedgsekcakyisdivgfv.dled..h..rvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdsc

MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQiIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESgvQEAYDAF
 . | ||   .  | |.. |||||.||||.....| ..  |   .  ..  ...| .  .|  |... .||... ...|...  | |.  .  .. .  |
dtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn..eqewtkf

LEQYKKV
 | | |.
ketyaki

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 76-319 8e-46 151.3 In-house 5-242 (250) alignment
Range on Protein: 76-319
Range on HMM: 5-242/250.0
KEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKkCFEYFPSKKGD
|. |.  |||| |.  ||. || ||        .|| | .. . .. | || ||.||..|  ||| | ...|.. | || |. |.. . . .|.| .| .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

VMdfdeGgqKISVKCESSvtysfraDAKANVTATEIVIEGPGEKT-RKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTG
      |  .. |.  |.       . .|..| .....    ..  |   ..|.  |||.|||.   ||||||.. .       ..|..|.||||.||.|
ky....G..dvtvsllsk.......eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

SVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
. . .. ....|   ...|   |.. .. ..| ..... .|| ||...||.. 
afiaidavlerlkkekvvdv.fkvikvlrkdrphavesleqyvfvyeiilkal

subfamily_PTPRK_pd Subfamily PTPRK 69-317 1.6e-44 147.0 In-house 32-275 (314) alignment
Range on Protein: 69-317
Range on HMM: 32-275/314.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEY
||   | |. ..  |||..|.   |. ||.|   .|    .|| |... . ..|. || || ||..| .||| . |...   | || .. |.|. || .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

FPSKKGDVMDFdeggQKISVKCESSVTYSFRADAKANvtateivIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAG
.| .     |.    .   |..|    .  |  .  .       .. . |..|.  ....  ||| .||    ..|.|. .      ...|.||||||||
WPedtevygdi....kvelvetellaelvvrifrvek.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaG

IGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILN
 ||||  .... ..| .   ...|   ..  ...... | ..|  || |...|||.
aGrtGtfiaidivldmieregvvdv.fnavktlrsrkvnmveteeqykfiydvile

0041856 (Phosphotyrosine protein) phosphatases II 82-323 9.3e-44 144.5 In-house 3-175 (182) alignment
Range on Protein: 82-323
Range on HMM: 3-175/182.0
GKNRYKDVGCLDNNRvklegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgakkCFEYFPskkgdvmdfdeggq
 ||||.|. . |..|       .  ||.||... .  ..|||.||.|| .|.|||. | .. .. .| .|.         .. |.|              
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............

kisvkC-EssvtysfradakanvtateiviegpgekTRKTTHYHWNDWPDRGVPAaDMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQlla
       .                            .|  ..|..  ||| |||     .|...| .. ..||..||||||.||||..|.. ... .   
.....ell............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...

gQiiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
 .   . |...  . ..|.....|  || |.....| ... ||
.g..vsleeavklvrsrRpgmvitpnqyfflqlallellllkk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 71-321 1.1e-43 144.4 In-house 35-279 (315) alignment
Range on Protein: 71-321
Range on HMM: 35-279/315.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNfLEKGAK-KCFEYF
. .. .| ..  |||||..  ||..|||||       ..|| | |. .  . | .|..|.||. .  ||| | .|.||  | |. . ...| | ||  |.
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk.kqegdkikcrqyw

PSKKGDVMDFdeGgqKISVKcessvTysFRADAKANVTATEIvIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGI
| .|.| ..|  |  .|.|.     .  .  .| .. .| .. .   .|..|. | .....|||.||.    ..|.|. . . ..|    ...||||||.
Pdrkadsvef..G..sikve.....l..lsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGv

GRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|||| |. .. ...|.  .. .|   ... .. ..|   .||. .| |.....|...  
GrtGvvisidevvaqikrtrsvdvf.nfvknlrakrpylvqteeeyafiydavledllw

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 42-321 4.6e-43 142.1 In-house 8-285 (290) alignment
Range on Protein: 42-321
Range on HMM: 8-285/290.0
LKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE-----GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
 .||.    |  .| |..|  .  ..  ....     ..  .||....   |.||. |         ..|||.| |.    . |..| ||.|...| .||
gefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF

WYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgDVMDFDEggQKISVKCESSVTysFRADAKANVTATEiviegPGEKTRKTTHYHWNDWPDRG-VPA
| . .|.||  | ||.|  |.| .||  |.|..  |. ...|   .| .  |....       | .|. ..      ...... |.|.   |.. | |..
WkliwqekvtiivmltniieegkvkCqqYWpds..dtkayge..fsikllneetln..eyierklevknkn.....sagakqsvtqyqitnwdstgkvtn

ADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
    .| . |      .. ...||||||...||..  . ..  ...    . ||   ..| .   |. .|.||  || ...|..|.|. .
pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidv.fqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 78-320 6.1e-43 141.7 In-house 41-277 (515) alignment
Range on Protein: 78-320
Range on HMM: 41-277/515.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVM
  .  |||||..  .|..|||||       ..|. | |. .  | | .|..|.|.. .  ||| . .|..|  | |. .  |    || .|.| | || .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

DFdeGgqKISVKcessvTYSFRADAKAnVTATEIVIEgpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTGSVVM
 |  |  .|.|.     . |  |.. . .  .  |.   |...|  | .|...|||.|||    ..| |. . . ..|    |...|||||.|||| |. 
kf..G..sikve.....lvsleactgg.ikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

LEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. .. .   ....|   ... .| ..|   .||. || |.....|... 
idsvvahakttrmvdvf.nfvtnirqkrpylvqtqeqyafiygavledll

subfamily_PTPN14_pd Subfamily PTPN14 66-321 2.3e-41 136.7 In-house 35-298 (300) alignment
Range on Protein: 66-321
Range on HMM: 35-298/300.0
FNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW--PHEYIHANYVATP--TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKK
 .   .... |  ..| |||.|||   ..|||.|       ..|| |  . ..  .. . .| .|.|||.|. ||| | ....|. | || .  |.| .|
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CFEYFPSKKGDVMDFDEGgqkisvkcESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------------R
.|.|||...      . |        .  ||  |. |... .| .  .   | .. |.  |  ..||||.|||      |. ||.              .
sfkyfPkleskkktvefg........kfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
 || |..||||||.|||| ... . ..  |  .. ||  .|.| .. |||   .|| ||| ||..|...|...
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikylkn

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 40-321 5.5e-41 135.4 In-house 6-280 (287) alignment
Range on Protein: 40-321
Range on HMM: 6-280/287.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEK-MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWY
.. .||..  .|  .| .  |. . . .. |. .      |   |||....   ||.|| |.|   ..|| | .. .  . |.|| ...|. .|  .|| 
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk

MCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdV-MdfdeGGQKISVKCESsvTYsfradAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG-VPAA
.  . .|. | |||.  |.  ..|..|.|..|  | .    |  .|..  |   ..     |.  .   |.  ..  ..... . |.  .|...| |.  
liddrnvtaivmlcqekendeevcyqyWpeeks.vvl....Geyniellnee..vn.....agyierklevknknkagdkqqvkqyqitnWdstgkvtep

DMAVLELLE----NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
   .| . |    . ......||||||...||..  .  .  ...     .||   ..| .   |. .|.|| .|| |. ...|.|   
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 69-321 3.2e-40 133.0 In-house 38-281 (315) alignment
Range on Protein: 69-321
Range on HMM: 38-281/315.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEY
.  ..  |. ..  |||| ..   |. ||.|   |     .|. ||..   . ..|.|..|.|.  .  ||| . .....  | || |  |.  .|. .|
lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky

FPSKkgdVMDFdeGGQKISVKCESSV-TYSFRADakanvtatEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR----PSKGPIVVHCSA
.| |    . .  |   .. | |     |. |.          .|    |.. |.   .|.  ||| |||.  .....|  ...     | |.|||||||
wpdk...kviy..Gkitvtrkseevnteytvrtl........svvf...gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|.||||. . |. ..||. | ..||   ... .. ..| . .|. .|| |.....|. |  
GvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalletfvc

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 82-329 6.1e-40 132.0 In-house 37-280 (285) alignment
Range on Protein: 82-329
Range on HMM: 37-280/285.0
GKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNP-KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGG
  ||| || |... || |.    ..||||...  | .    .| || || .| .|||.| ||.|. |..||| ..| | .||  |.| | |.|. | .  
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye

QKISvKCES-SVTYSFrADAkANVTATEIViegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELL---ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMD
  .. .|.  ... .   .|   |. ||        .     | .   |||.  |     ..||    ..  | . ||.||||||.||| ..| ..|   
itlt.eckeeaiagti.lna.ltvinteda....sseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

QLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESG
...    |.    |. ..   | ...|.  |.||.. |...||  . ... .|
rimenpniem.ldivremramrfqavqshmqflflyvvlmeyfigegvvertg

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 81-316 9.8e-40 131.2 In-house 4-236 (237) alignment
Range on Protein: 81-316
Range on HMM: 4-236/237.0
AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmdfDE
  |||| .. . | .|| |.|.    .|| |.|.      ||..|..| ||| .| ||| | .|.|   | ||  ..|.  .|| .|.|| .        
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ay

GGQKISVKC-ESSVTYSFRADAKANVTATEiviegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----AR--PSKGPIVVHCSAGIGRTGSVVML
|   .|.|  |    |. |.   .. .  .        . |    |..  |||||||    |.| .  |    ..  .  || ..|||||.|||| ....
gvltvslkkkeefsdytvrslllskrltlk........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

EYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVIL
. .. |    ...|  .  .  | |.|   |||  ||.|.||.||
damlrqakekkvvdiyn.yvysieedrpyiiqtkdqyvfihqtil

subfamily_egg_pd Subfamily egg 65-341 2.5e-39 129.8 In-house 25-291 (307) alignment
Range on Protein: 65-341
Range on HMM: 25-291/307.0
RFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKgaKK
   | . ..   .. .  | | | | | |  |||||   | .  ..||||.|        ||..||||  |  ||| | .|..|.|| ||    |   ..
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CFEYFPSKKGDVMDFDEGGQKISvkCessVTYSFRADAKANVTATEIviEGPGEKTRKTTHYHWnDWPDRGVPAADMAVlelLENARPSKGPIVVHCSAG
|  |.|  . | . .  |. .|   .   .    .||   .||   .   |. .. |   |. . |.   .     . |   |  .|    |.||..  |
ceyywpkaesdslvtvpGslrie..n...lkvdskadplfrvtklkl..vGgddeerflehwqg.dvnnssdvysplrv...lrklrnlskpvvvqdilG

IGRTGSVVMLEYIMDQLLAGQIIDDG-EKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKkLMDESGVQEAYDAFLEQY
. .....| .|  . .|| | |      .  | .  .|. |...  .||||....| .||   .     ..  |. .||..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv.igsakeldvdyerwleer

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 78-318 2.6e-39 130.4 In-house 59-290 (319) alignment
Range on Protein: 78-318
Range on HMM: 59-290/319.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgAKKCFEYFPSKKgdvm
 |.  |||. ..   |.|.||||   |    .|| | .|.   .....| .| ||. | |||| | .. ..  | .|        .|| .|.| |     
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki....

DFDEGGQKISVKcesSVTYSFRadakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSV
.  |.  |..|.   ||. .        |   |.  .|  .  || | .|.  ||| |||   . .. |...          . .||||||||.||||  
vikeerfkvkvd...sveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

VMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
..|. ..|..   . .|   ...  . .|||. .|  .|| |..  .|. 
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 79-318 6.2e-39 129.2 In-house 24-254 (284) alignment
Range on Protein: 79-318
Range on HMM: 24-254/284.0
QEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgAKKCFEYFPSKKgdvmD
|.  |||. ..   |.|.||||   |    .|| | ...   .....| || ||. | |||| | .. ..  | .|        .|| .|.| |     .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki....v

FDEGGQKISVKcesSVTYSFRadakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSVV
  |.  |..|.   ||. |        |   |.  .|  .. || . .|.  ||| |||   . .. |...          . .||||||||.||||  .
ikeerfkvkvd...sveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

MLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
.|. ..|..   . .|   ... .. .|||. .|  .|| |..  .|. 
vldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysallee

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 80-317 1.2e-38 127.7 In-house 48-277 (439) alignment
Range on Protein: 80-317
Range on HMM: 48-277/439.0
EAGKNRYKDVGCLDNNRVKL-EGP-WPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAkkcfeYFPSKkGDVMDF
.  |||||||| .|  || | | |  ||  || |||.    ..| .| ||.| ..|. ||| . .. |.  | ||.|..|        |.||. ..|.  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd.aevcyg

DeggqkISVKCESSVTYSFRADAKANVTATeiviEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----ENARPSKGPIVVHCSAGIGRTGSVVML
|     |.|...  .     .    .|          .|| |   ..|.  |||. |||    ||..|      | .   ||.|||||||.||||... |
d.....iavrvdrnielpnyvirgfkvfne....rdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiial

EYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILN
.  ..|| . . .|  . |.  . .||.. .|. .||.|... .|.
dialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle

0046846 (Phosphotyrosine protein) phosphatases II 101-320 2.4e-38 127.0 In-house 8-174 (176) alignment
Range on Protein: 101-320
Range on HMM: 8-174/176.0
GPWPHEYIHANYVATPtnpkRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMdfdeggqkisvkcessvtysfradak
 ...  ||.||.....    |.|.||.||..|.|||. | .. .......|..  |.|  ||. |.|  ..  .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

anvtateiviegpgektrkttHYHWNDWPDRGVPAAD--MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyimdqLLAGQIIDDGEKILVKICEQR
                     .|.. .||| |||  .  . .||....|. ..||..||||||||||| .|..      ||  .   . |..| .. |||
.....................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqR

N-NSIQTDAQYLFVHQVILNYFR
  ...||..|| |.....| ...
plgavqtpeQyrflyefellllk

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 78-317 6.7e-38 125.2 In-house 31-264 (283) alignment
Range on Protein: 78-317
Range on HMM: 31-264/283.0
AQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVA---TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGDvM
 ..  |||....   |..||.|. . ...|| | ..       . |..| .|.||..|  ||| | ...|.  | || .. |   .||  |.|.. |  .
denkrknrnqeivpadqwrvelk.sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.Gs.e

DFdeGGQKISVKCESSVtYSFRADA-KANVTateivieGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELL-ENA-RPSKGPIVVHCSAGIGRTGSVV
|.  |   .... | .   ||       .|        .  ..|   .||  .|| . |  |    .  ....  .  .  |||||||||.|||||.  .
dy..Geftvtlrketts.nsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

MLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILN
 .   ....|.  ..|   ...  . |||   .||  || .||...|.
aasasvkdaltesvvdv.favvkimreqrmmavqtldqyklvhelvle

0043147 (Phosphotyrosine protein) phosphatases II 105-313 1.7e-36 120.9 In-house 5-155 (172) alignment
Range on Protein: 105-313
Range on HMM: 5-155/172.0
HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFlekgakkcfeyfpskkgdvmdfdeggqkisvkcessvtysfradakanvt
. ||.|.|. ..  |.|||.||.||  |.|||| |... .. .|..|...                                                  
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

ateivIEGPGEKTRKTTHYHWNDWPDRGVPaADMAVLELLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllaG-QiidDGEKILVKICEQR
        |   .|   .|..  ||| |||     .||.||      |. ..||..||||||.|||| .|.. ...           . |...  . |.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl...sleeavalvrekR

NNSIQTDAQYLFVHQ
....|.. || |...
pgavqnpsqyrflyy

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 72-321 5e-36 119.0 In-house 30-279 (287) alignment
Range on Protein: 72-321
Range on HMM: 30-279/287.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKL--EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
.|| .|  .. |||| ||  .|..|| |  ||    .|| |||||. |. ..||..|.|.  |  ||| . .. ..  . ..   .|.. .||..|.| .
fkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

kGDVMDFdeGGQKISVkcessVTYSFRADAkaNVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA--D--MAVLEL---LENARPS--KGPIVVHCSA
    |    ||  . .     . |. .       . .  .|.  ....|    ... .|||.... .       ||.    .| || .   ||.|||...
.evPmrv..GGysvvl.....ldydikePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

GIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
||||.| .. .  ....|.    .|   ...... |.|.  .|.  |. .. . .  |.. 
GiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyykt

0036282 (Phosphotyrosine protein) phosphatases II 105-313 5.1e-36 119.3 In-house 2-164 (174) alignment
Range on Protein: 105-313
Range on HMM: 2-164/174.0
HEYIHANYVATPTNPKRFICTQAPLEktcadFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkgdvmdfdeggqkisvkcessvtysfradakanvt
. ||.|...     ..|.|..|.||.     ||.|... ......||..  |.|  ||. |.|.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

ateivieGPGEKTRKTTHYHWNDWPDRGVPAADMaVLELLENARPS-----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLagQIIDDGEKILVKICEQRN
        .   .|   .|..  |||.|||  .. .||... ..       .||..||||||.|||| .|.. ... .||  .  .|  ... ..  || 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp

NSIQTDAQYLFVHQ
...||. || |...
gmvqtpsQyrflyy

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-321 1.7e-35 117.2 In-house 22-295 (301) alignment
Range on Protein: 61-321
Range on HMM: 22-295/301.0
VGMRRFNDFEKMKAFkEAQEAGKNRYKDVGCLDNNRVKLEGPW-----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
  ... .| . .  . . ...  ||.|..  .|.||. |.         .||| |.|.   .. |.|| .|.|..|| .||| . .|.|.  | |..|  
kelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlk

EKGAKKCFEYFPSKKGDVMDFDEGGQKISVKC--ESSVTYSFR---ADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----E
|.  .||..|.|. . .  .| .   ... ..   . |  ..     |.  |      .      .... . ..  |||. ||      ||. .      
egtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihr

NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
. ....||.|||||....|.|  . ..  ..|  |  ..|   ..   .  ..   ..|  || ....||  |.. 
qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf.qvtkavrrskpgaVtTLeqytsiydvidmylql

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 80-320 3.2e-35 116.7 In-house 51-285 (297) alignment
Range on Protein: 80-320
Range on HMM: 51-285/297.0
EAGKNRYKDVGCLDNNRVKLEGPWPH---EYIHANYVatPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNfLEKGAKKCFEYFPSKKgdVMDF
.  |.|||..   | .||||.    .   .|. | .|  ..| .|.|.|| | . | |||| | ....|  | || . .... |||  |.. |   |. |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlnd.dnerdkkcaryWsdkg..vttf

degGqKISVKCESSVtysfraDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
   | ..||. .|        . .  .  .  | .|   ..|    |.. .|||. |.      ..|.|... |      ..||..|||.||.|||| ..
...G.dvsvvllsvs......ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

MLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
 .. .. .    . .|   ... |. ..| . .||. || ||....|... 
tidsvvaeakrekevdif.glvkklrqerpylvqtkeqykfvyvavleall

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 70-319 4.4e-35 116.3 In-house 38-288 (325) alignment
Range on Protein: 70-319
Range on HMM: 38-288/325.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEyIFMLCNFLEKGAKKCFEYF
  .|.    ..  |||.|.|  ||..|| ||     |. .|| |.|. .  . . |. .|||| .|  |.| . .. .   . .. | |..| ..|  |.
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrcavyw

PSKKGDVMDFdeGGqkISVKCESSVTYSFRADAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPA---ADMAVLELL----ENAR---PSKGPIVV
| . |.   |  ||  . ||  .  ..|     . .|  ..      . .||    ...  |.| ||.    . ...|.|.    |  .    . .||.|
pkemgksktf..Gg..levklrtieeisdyvhrvldvkqvk......kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||||.||||  . |  ......    .|  .  . |. ..| . ..|  || .... . ...
hcsaGvGrtGvfislysalakvieesrvdifg.fvkklrkdrpsmvetvdqyiliyealveay

0049772 (Phosphotyrosine protein) phosphatases II 81-323 5.1e-35 117.1 In-house 47-284 (314) alignment
Range on Protein: 81-323
Range on HMM: 47-284/314.0
AGKNRYKDVGCLDnNRVKLeGP---WPHEYIHANYVATPtnpKRFICTQAPLEKTCADF----------WYMC--YQDKVEYIFM---------------
  ||||.|. . | |||.| .      . ||.|.|| ..   ..||.||.||| |. ||          | |   .. .| .| |               
rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCNFLEKGAKKCFEYFPSKKgdvmdfdeggqkisvkcessvtysfradakanvtateI-------ViegpgekTRKTTHYHWNDWPDRGVPAAD
      |... ..|.  ......  |                                             .       .|   .|.. ..|| ..|  .
AlgKtpllildgngneptaadlellk.....................................eelydpelf.......erlgikylripvpDgsaplle

M--AVLELLENArPSKGPIVVHCSAGIGRTGS-VVMLeYIMDQLlagQIidDGEKILVKICEQRN-----NSIQTDAQYLFVHQVILNYFRKKK
.  ..||..|.| . .||..|||.||.||||. ||.  |.| .|   ..  . |..|  . ..|      ..|..  ||.|.....|.|....|
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa.ylmkll...gv..sleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 89-325 1.1e-33 111.7 In-house 27-257 (290) alignment
Range on Protein: 89-325
Range on HMM: 27-257/290.0
VGCLDNNRVKLEG---PWPHEYIHANYVATPTNpKRFICTQAPLEKT-------CADFWYMCYQDKVEYIFMLCNFLEKGAK----KCFEYFPSKKGDVM
|  . ..|| |.|       .|||||.|  | .  |.| ||.|.||.         .||.|  |.||. . |||.| || |.     | .|.| . |. .
vpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

DFDEggqkISVKCessvtysFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyI
 |.     ..|||           .. .|   |.|..  .|.  . ||.  ..| .. |.     .|.|... . || |..|||  || |   .  .. .
kfkg....ltvkC.......kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.l

MDQLLAGQ-IIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILnyfrkkklM
  |..|..      |..| .. .||.. |... .. ||  .|.        .
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv........l

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 74-318 2.3e-33 110.1 In-house 39-235 (392) alignment
Range on Protein: 74-318
Range on HMM: 39-235/392.0
AFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfeyfpskk
. ..  .  |||||..  .|..|||||       ..|. | |. .  | | .|..|.|   .  ||| | .|..|  | |. .. |              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

gdvmdfdeggqkisvkcessvtysfradakanvtateiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTG
                                           |...|  . .|. .|||..||    ..|..... .   |    |...|||||.||||
..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtg

SVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNY
 |. .. .. .    ...|   .....| ..|   .||. || |..  .|. 
vvisidsvvahakktrmvdv.fnfvtnirrkrpymvqtkeqyafiygavled

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 76-316 8.2e-33 108.5 In-house 4-238 (239) alignment
Range on Protein: 76-316
Range on HMM: 4-238/239.0
KEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
|.  .  |||| ..   | .|| ||     || .|| |.|.     .|| .|.||  .| .. ||| | .|..   | ||  ..|   |||..|.|    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

DVMDFDEGGQkisvKCESSVTYSFRADAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGS
   ..    .    | |    |  |.   ..|  ||          |   .||.  |||.|||    ||| |     ... |   | |.|||||.||||.
kycnlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVIL
..... .. |    . .|  .  .  | |.|   .||  ||.|.|  .|
flvidamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavl

subfamily_PTPRN_pd Subfamily PTPRN 41-315 8.3e-33 108.3 In-house 17-288 (297) alignment
Range on Protein: 41-315
Range on HMM: 17-288/297.0
ILKFVQRTLEKmPQGLRAEFVGMRRFNDFEKMK-AFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVAT--PTNPkRFICTQAPLEKTCA
.|....  |.. .. |..|. .. ...  .. | . |. . . |||.|.|   |..||||.       ..|| |  .    | .|  .| ||.|| .| |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva

DFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGG-QKISVKCESSVTYSFRadaKANVTAteiviegpgEKTRKTTHYHWNDWPDRGV
||| | ... |  | .|..  |.| |.| .|.| .  .| .. |       . |.  .  ||      |. .         ..||  | .|.  ||..||
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfy...lknlqt.........setrtvtqfhflswpeegv

PAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVI
||.  ..||.        |    |||||||.| ||||  .... ....|| |    |    | .. .||.. ..| .|. |. ...
PasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 79-317 8.8e-33 108.4 In-house 6-238 (239) alignment
Range on Protein: 79-317
Range on HMM: 6-238/239.0
QEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVM
 .  |||| ..   | .|| ||     || .|| |.|.     .|| .|.||  .| .. ||| | .|..   | ||  ..|   |||..|.|       
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

DFDEGGQkisvKCESSVTYSFRADAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGSVVM
..    .    | |    |  |.   ..|  ||          |   .||.  |||.|||    ||| |     ... |   | |.|||||.||||....
nlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv

LEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILN
.. .. |    . .|  .  .  | |.|   .||  ||.|.|  .|.
idamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavle

0049260 (Phosphotyrosine protein) phosphatases II 117-313 7.2e-32 105.6 In-house 6-144 (152) alignment
Range on Protein: 117-313
Range on HMM: 6-144/152.0
TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFpskkgdvmdfdeggqkisvkcessvtysfradakanvtateiviegpgek
 .|..||.||.|.. |.|||| | .. .. .| ||...||.|  || .|.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

trkttHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllagqIIDDGEKILVKICEQRNNSIQTDAQYLFVH
     .|..  ||| |||  .. .|.||.     |. ..||..||||||.|||| .|.. ...          . |...  . |.|......  |. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

Q
.
e

0044763 (Phosphotyrosine protein) phosphatases II 98-322 1.2e-29 98.6 In-house 11-174 (178) alignment
Range on Protein: 98-322
Range on HMM: 11-174/178.0
KLEGPWPHEYIHANYVAtptnPKRFICTQAPlektcADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdvmdfdeggqkisvkcessvtysfra
.|||..  .||.|...     |  ..... |     ||.. . .. .. .| .|.. || |  ||..|.|.. |                          
nleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

dakanvtateiviegpgektrktTHYHWNDWPDRGVPA---ADMAVLELLENAR-PSKGPIVVHCSAGIGRTGSVVMLEYIMDQllagQIidDGEKILVK
                        .|..  .|| |||      ....|..|.|. ...||..||||||.||.|..|.. ... .    ..  . |...  
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl..sleeaiel

ICEQRNnSIQTDAQYLFVHQVILNYFRKK
. |.|.  .... |. ..... | .. ..
vrerRp.ivpnpgqlrqLyefelrllkes

0051082 (Phosphotyrosine protein) phosphatases II 106-315 1.7e-28 94.5 In-house 4-149 (151) alignment
Range on Protein: 106-315
Range on HMM: 4-149/151.0
EYIHANYVATPtnpkrFICTQAPLEktcaDFWYMCYQDKVEYIFMLCNFLEKGakKCFEYFPSKKgdvmdfdeggqkisvkcessvtysfradakanvta
 ||...||        ......||.    ||. . .. .. .|..|..  | |  .| ||.|.                                     
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

teiviegpgektRKTTHYHWNDWPDRGVPAADMAVLELLENARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQllagqiiDDGEKILVKICEQRNNSIQT
            .. .|... |||| |.|    ||||.|| ..   .||..||||||.|||| .|.|  .. .        . |..|  . ..| ...|.
............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp

DAQYLFVHQVI
  |.||.....
nqqflfqlfal

subfamily_CG7180_pd Subfamily CG7180 76-319 3.7e-28 93.0 In-house 38-290 (296) alignment
Range on Protein: 76-319
Range on HMM: 38-290/296.0
KEAQEAGKNRYKDVGCLDNNRVK---LEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAkKCFEYFPSKKgd
 ...  .|||. .|   |.|||    |.|    .|| | || . . .| .| |.|| ..|  .|| . |..... . .|..  .    .. .|.| |   
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..

VMDFDEggqkISVKCESSVTYSFRADAKANVT----ATEIVIEGPGEKTRKTTHYHWNDWPD-RGVPAADMAVLELLE-------NA--RPSKGPIVVHC
  .. |    | |.  .. .|.     .  .|    |.    ..   .||  .....  |.    ||    |..||..       ..  .| .||.||..
keqyge....ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYF
| | .|.|  . ..  ....   . .|  |  . .. ..|.. ...  .| .. .|.|...
sdGasRsGvylaidanlelvekeeevdvFe.avktlrrsRpqLvenveeYkyiYdvlleav

PTPc_DSPc_SM00012 220-316 3.8e-28 93.1 In-house 2-104 (105) alignment
Range on Protein: 220-316
Range on HMM: 2-104/105.0
TTHYHWNDWPDRGVPAADMAVLELLENARPSKG------PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQ
 .|||...||| |||    ..||||.. . .|       |.|||||||.|||| .|.|.....|| ...  .| ..|. .. .||....||..||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VIL
..|
all

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 54-331 1.2e-27 91.1 In-house 26-296 (302) alignment
Range on Protein: 54-331
Range on HMM: 26-296/302.0
QGLRAEFVGMRRF-NDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNPKRFICTQAPLEKTC---ADFWYMCYQDKVEYIF
. ...||  .  .  | || ||||.  .  ||. .|| .||.|.||||.  | .|..|  |  |   .  | .| |  ..    ..|| | .|.|.  ..
aevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLCNFLEKGAkKCFEYFPSKKGDVMDFdeggQKISVKCESsVTYSfrADAKaNVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMA----VLELLE
.|    |       |.|| | ||  ..    .|. |     | ..   ..| .  . |.. ||  .    .. |. . |..  ||    .    . .. .
ilvgeeelkk.tlselfpkksgdykey....gkmfvNnrk.Veka..eeek.tryviEvlPegcsnsvl.anvyvltnWkqkkvpvkyaeliktaakvfa

NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHqVILNYFRKKKLMDESGVQ
.  ... ..|.    |.|| |... |   ...| .|.     | |. .| .|| .....  || ... ..|... |||. .... .
kkikadentvivSknGaGRagafltlavaveklqkgkepnike.ivksiRsqRpravdslkQyvsly.ialllyikkkvtkpeekk

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 76-235 1.8e-27 91.0 In-house 26-181 (297) alignment
Range on Protein: 76-235
Range on HMM: 26-181/297.0
KEAQ---EAGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVATPTNPK--RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
  |.      ||||.|.   |..|||| .  . ..|| |.||. | ...  ..|..| ||..|  ||| . ... |  | |.... | | .||. |.|| 
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

KGDVMDfdeggqKISVKCESSVTYSfraDAKANVTATEIVIEGPgEKTRKTTHYHWNDWPDRGVPA
... .         .|  |   ..|   |   .|  ||. .    ...|. .|  .  ||| |||.
vqerlk......agdvvveflssts...defdrviltelqliyr.sesrvvrhvqflswpdhGvps

subfamily_ptpA1_pd Subfamily ptpA1 79-277 8e-27 89.0 In-house 46-255 (418) alignment
Range on Protein: 79-277
Range on HMM: 46-255/418.0
QEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATpTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmD
... |||| ..  ..  ||.|.        .|| |||.   . ||.||||| || .| |||| | .....  | ||    |.   ||  |.| . |   .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.q

FDEGGQKISVKCESSVTY-SFRADAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------RPS---KGPIVVHCSAGIGR
|   |.   |    ||       | . .. . .| .   || ||  |.|... |||. .|     . .|| .         ||   . ||.||||||.||
fsiygngnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGSVVMLEYIMDQ
||...    .| .
tgtfctavimmkk

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 126-330 1.5e-25 84.3 In-house 97-294 (302) alignment
Range on Protein: 126-330
Range on HMM: 97-294/302.0
QAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQK-ISVKCEssVtYSFRADAKANVTATEIVIEGPGEKTRKTTH-Y
  |  .|.  .| .  | .|  .  ||.| |.. ||| ||.  | |... | .   | .||| .  .   |    .... . ||  |   .|..|| .  
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd..l.eeftdkksfklytveiknekkkkkvkktvdil

HWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVIlnyfrKKK
..  ||| | |.   . |..|      |  ..||||||.||||..| . | . || . . . |  .|.. . . |  ..|.. | ...  ..      | 
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv.....tkg

LMDESGV
||.  ||
lmekagv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 130-328 8.2e-25 82.3 In-house 38-230 (255) alignment
Range on Protein: 130-328
Range on HMM: 38-230/255.0
EKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESsvtysfrADAKANVTATEIVIE-GPGEKTRKTTHYHWNDW
  | . |. .  | | | . |||.| |.| .|| .||| .| . . . .    ..| .         . |.  . . ||. . |   ||.. .||... |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGW

PDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
...  |     .|..|  .| || ..|||||.||||. . |. |..  ...      . .. |  ..| .. ..|. .|.|  |  |   ..|...  |.
ieknaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

LMDES
 ... 
eleak

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 59-319 9.6e-23 75.5 In-house 11-259 (267) alignment
Range on Protein: 59-319
Range on HMM: 11-259/267.0
EFVGMRRFNDFEKM-KAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEK
||  ...  | .     .   . . .||. |.   |..|| |     .||| | || .    . || || ||..| .||. .  . ||  | .| .  . 
efelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd

gakKCFEYFPSKKGDVMDFDEGGQKISVKCESSvtysfradaKANVTATEIVIEgpGEKTRKTTHYHWNDWPDRGV------PAADMAVLELLENARPsk
   .   ..| | |.   ...   . |.. |             .. . |. ..   | ... | |... |           |   .   . |||. .  
...nirlfwPPkmgqakkyqdltvehslekeen.........dyqiitlelkfk..nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnr..

gPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
 |.||.||.|.||.|. ....  ....   .. |   . | || .||   ..|  .|...|... .| 
.PlvvacsdGvGrsGtflvidsqleraktegvsd.ifdflrkirsqriglvdtkeryiyihellaeya

subfamily_CG42327_pd Subfamily CG42327 105-250 1.1e-22 75.2 In-house 56-193 (319) alignment
Range on Protein: 105-250
Range on HMM: 56-193/319.0
HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgdvmdfdEGGQKISVKCESSVTYSFRADAKANV
 ||..|.||  . . |  .|..|..||.. .||| . .. .   |  |..  |.| |.| ||.|.|        |...  |.  .  ||   |.  .  .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk........etldntslyGdilvtlkgrevkdrya

TATEIVIEGPGEKTRKTTHYHWnDWPDRGVPAADMAVLELLENARPS
..| .. .  .|..|. ||| . .|.. .||| . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

0048076 (Phosphotyrosine protein) phosphatases II 195-318 1.1e-21 72.4 In-house 22-142 (145) alignment
Range on Protein: 195-318
Range on HMM: 22-142/145.0
FRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQllaGQiiDDGEKIL
..  .. ..|.   .   .   .|. ..|.. .|||.|||   .  ...||..|.|....||..||||||.||||..|.. |.| .    .   . |..|
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll...lg..vsleeal

VKICEQRNNSIQTDAQYLFVHQVILNY
 .. .|| ...... |. |.....| .
elvrsqrpgavpnpgqlrflyefelel

subfamily_hpo-7_pd Subfamily hpo-7 125-332 3e-21 70.5 In-house 39-242 (263) alignment
Range on Protein: 125-332
Range on HMM: 39-242/263.0
TQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESSVTysfradakANVTATEIVIE--GPGEKTRKTTH
... | .| . |. .  | | | . |||.| |.| .|| .||| .| . . . .    ..| .  ..           .  |. ...  |   ||.. .|
lysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan....vnvcttkvqs........dvllktlellstlgeKkkthtvkh

YHWNDWPDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKICEQRNNSIQTDAQYLFVHQVILN
| .. |...  |     .|..|. || || ..|||||.||||. . .. | .  ...      . .. |  ..| .. ..|. .|.|  |  |   ..|.
ysykgWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

YFRKKKLMDESG--VQE
.. .    .|     ||
fvlnnfakgeleakyqe

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 79-318 1.3e-19 64.9 In-house 46-278 (303) alignment
Range on Protein: 79-318
Range on HMM: 46-278/303.0
QEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPTNpKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPsKKGDVMDFDE
..  |||. || |||  .|||       ||||.|.   .. |. | || || .|.|||| |  ..||  ...|    |         || .. | ..|.|
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfee

ggQKISVKCESSVTYsfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--------MAVLELLENARPSKgPIVVHCSAGIGRTGSVVM
  . | |     |         ..  .  ..    |.       .|...||   .|.            .  .| .  .|. | |    .| ||.|.  .
..rsirvgefkrvel.......gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

LEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNY
.|     | . |   |  | | .. . |  ..|  .|. .|. .. ..
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh

0048179 (Phosphotyrosine protein) phosphatases II 216-313 2.8e-19 64.7 In-house 45-139 (144) alignment
Range on Protein: 216-313
Range on HMM: 45-139/144.0
KTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllAGQiiDDGEKILVKICEQRNNSIQTDAQYLFVH
 .|  ..|.. .|||.|||   .   ..||..|.|....||..||||||.||||..|..  ..      .   . |..|  . ..| ...... |. |..
leregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgqlrfLl

Q
.
e

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 77-169 4e-18 60.3 In-house 44-153 (350) alignment
Range on Protein: 77-169
Range on HMM: 44-153/350.0
EAQEAGKNRYKDVGCLDNNRVKLE-----------GPWPHEYIHANYVATP-----TNPK-RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGA
  .   |||||..   . .||||.              . .|| |||.  .      ||. ..| ||||| .|  ||. .....||. | .| .  | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

KKCFEYFPSK
.|| .|..  
ekcyrYWqeg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 216-318 1.9e-15 51.2 In-house 87-193 (440) alignment
Range on Protein: 216-318
Range on HMM: 87-193/440.0
KTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLF
..|   .||.. |||.|||     ||.....        ..||..|||||| |||| .. .. |. .    . ||    ..  . ..| . .||  || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyaf

VHQVILNY
||...|. 
vheavleg

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 241-317 1.1e-14 49.0 In-house 218-293 (297) alignment
Range on Protein: 241-317
Range on HMM: 218-293/297.0
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |. . | . ...||||||.||.| ||. . |...|  .  | |   || .. |||   .||  |. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlk

subfamily_CG42327_pd Subfamily CG42327 248-320 1.2e-12 42.1 In-house 244-316 (319) alignment
Range on Protein: 248-320
Range on HMM: 244-316/319.0
RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
| |.||.||||| |.|||| |.  .  . .|   .   |  ...  . ..| ....|  || |...|. .| .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 120-272 1.9e-11 38.5 In-house 4-155 (198) alignment
Range on Protein: 120-272
Range on HMM: 4-155/198.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL-EKGAKKCFeYFPSKKGDVMDFdeGGqkISVKCESSVTysfRADAK-ANVTATEIVIEgPgEKT
.|.|.|| || .| |||| | ..    .| |. .   .| |   | |.|. .  .  .  |   .|| ... .|   ..|   . .  |. .   |   |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..gs..lsvttktitt...kpdytitaliltnntta.p.pst

RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLE
|. .|| .  | ..  |   . |  ..     |         |..|||| | | ||  | |.
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 120-272 2e-11 38.4 In-house 5-156 (199) alignment
Range on Protein: 120-272
Range on HMM: 5-156/199.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL-EKGAKKCFeYFPSKKGDVMDFdeGGqkISVKCESSVTysfRADAK-ANVTATEIVIEgPgEKT
.|.|.|| || .| |||| | ..    .| |. .   .| |   | |.|. .  .  .  |   .|| ... .|   ..|   . .  |. .   |   |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..gs..lsvttktitt...kpdytitaliltnntta.p.pst

RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLE
|. .|| .  | ..  |   . |  ..     |         |..|||| | | ||  | |.
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 101-167 4.9e-11 36.5 In-house 86-154 (349) alignment
Range on Protein: 101-167
Range on HMM: 86-154/349.0
GPWPHEYIHANYVATPT--NPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFP
.  ...|| |||.  .     |..|.|||||  |  ||. .   ..|. .. | .  |.. .||  |. 
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 251-322 6.5e-11 36.5 In-house 262-347 (350) alignment
Range on Protein: 251-322
Range on HMM: 262-347/350.0
KGPIVVHCSAGIGRTGSVVMLEYIMDQL--------------LAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
  ||.||||||.|||| .| |.... ..               | .. |  . |. .. .|| . .|.  |..|... .|.||. .
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLr

subfamily_eak_pd Subfamily eak 83-236 3.1e-10 33.9 In-house 55-197 (332) alignment
Range on Protein: 83-236
Range on HMM: 55-197/332.0
KNRYKDVgCLDNNRVKLEGP--WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFdeGg
.| .| |   | . |.|      .  || |  .  .   ...| | .. |.    || | .. |   | .| . .|.. .|   ||| |  ....|  | 
rnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf..G.

qKISVKCESSVtysfradaKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA
 .. |.. . |        | |.  |  ..   |..| .  ||.   | .  .|  
.ildverkefv........krniletrllelskGnethrvlhykvfGwtettlpky

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 130-341 1.4e-09 31.0 In-house 128-331 (346) alignment
Range on Protein: 130-341
Range on HMM: 128-331/346.0
EKTCADFWYMCYQDKVEYIFMLCNfLEKGAKKCFEYFPSkkgdvmdfDEGGQKISVKCessVTYSFRADAKAN--VTATEIVIEGPGEKTRKTTHYH--W
|    ||||| ||.... ....    .|  .     |          ..|| . . |    .    |||   .    . |.. ||  .      |.|  |
esfvedfwymiyqeqihlvylmvp.ddklkntttslfnd........enggyqytgkm...finnrradvsgdpkeytievlpegnsdsvicqvhhhapw

N--DWPDRGVPAADMAVLELLENARPSKGPIVVhCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
.  . | . .|   |    | |.   . |  ||    | ||. | .   | ..||  | |  .  .|. .| .||  .... |||  .. ....|  .|.
khlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnng.iepniceimknikqqrpggvesfaqyasiyaivfdyiarkr

LMDESGVQEAYDAFLEQY
   .. |.   . |... 
ggkkapvnkdinrfidel

subfamily_PTPDC1_pd Subfamily PTPDC1 223-318 7.6e-09 30.3 In-house 85-175 (182) alignment
Range on Protein: 223-318
Range on HMM: 85-175/182.0
YHWNDWPDRGVPAADM--AVLELLENARpSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLagqiidDGEKILVKICEQRNNSIQTDAQYLFVHQVILNY
..   |.| ||.. .    .  ... |  ..| . ||| || |||| ..    .  . |      ..|| . .. ..| .||||  |  .|..  |  
vynfgwkDygvasleriLdivkvvafal.qegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksiqtreqvelvkefalfl

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 190-322 1.4e-08 28.6 In-house 200-341 (347) alignment
Range on Protein: 190-322
Range on HMM: 200-341/347.0
SVTYSFRADAKANVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMAVLELL----ENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL
.|.   |. .  |  . |.| ||  | |  .  |    || .  |     || |.     .. .|       . |.|| |  |. |. .||.   |..|.
avevdqrnknwmnkytvevvaegcseatf.akvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqv

LAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|.|.   | .... |. .||   .     | .  .  | |.. |
ldgkt.pdcddlfkkmrdqragvftmsifytyairaalfylklk

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 71-233 1.9e-08 28.2 In-house 87-235 (244) alignment
Range on Protein: 71-233
Range on HMM: 87-235/244.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfEYFPSK
 ||   . ... |||      .| ||| | .|     || | .|        .| || ||  |  ||| |  . .|. . .|    |.      ||.|  
vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds

kgDVMDFDEGgqKIsvkcesSVTYSFRADAKaNVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGV
  . ... |    |      .|| . | . | |. |... ||    |  .  | .   .||  | 
..eplewyee..di......tvtltdrdefk.nikasnleiesdmneshqaltmfqisnwpsdgt

DSPc Dual specificity phosphatase, catalytic domain 239-277 3.2e-08 28.5 Pfam-A 61-98 (133) alignment
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |......  |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt

DSPc Dual specificity phosphatase, catalytic domain 239-277 3.2e-08 28.5 In-house 61-98 (133) alignment
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |......  |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt

PTPc_motif_SM00404 239-276 3.4e-08 28.5 In-house 68-104 (140) alignment
Range on Protein: 239-276
Range on HMM: 68-104/140.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMD
.||. .|||. ..| ..||| ||. |......  |.|.
kvldfienaekkggkvlVHCqaGvSRSatliia.Ylmr

0038934 (Phosphotyrosine protein) phosphatases II 220-270 5e-08 28.3 In-house 67-134 (194) alignment
Range on Protein: 220-270
Range on HMM: 67-134/194.0
TTHYHWNDWPDRGVPAADMAVLE------------LLEN-----ARPSKGPIVVHCSAGIGRTGSVVM
.. |. ......|.   .. . .             |.      .. ..| ..||| ||.|||| .| 
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

subfamily_DSP19_pd Subfamily DSP19 229-278 5.7e-08 27.2 In-house 67-115 (152) alignment
Range on Protein: 229-278
Range on HMM: 67-115/152.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQL
|.  . .   ..|. .|.|| ..| ..|||.||. |. |||.  |.| . 
petdllsylkealdFieearskdgavlvHCnAGvSRsasvvi.aylmkke

PTEN_1 217-269 7.1e-08 27.5 In-house 91-148 (196) alignment
Range on Protein: 217-269
Range on HMM: 91-148/196.0
TRKTTHYHWNDWPDRGVPAADMAV--LELLENARP---SKGPIVVHCSAGIGRTGSVV
 ..   |.  ...| |.|  ..    .. .....    ... ..||| ||.||.| ||
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv

subfamily_eak_pd Subfamily eak 247-323 1.5e-07 25.1 In-house 233-309 (332) alignment
Range on Protein: 247-323
Range on HMM: 233-309/332.0
ARPSKGPIVvHCSAGIGRTGSVVMLEYIMdQLLAGQIIDD--GEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
. ||  ||.  .. |  |.|  |... .. .|. ... .    |....|. ..|. |. .. |. |.....|.|.....
tppsfapii.qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 80-154 2.7e-07 24.4 In-house 37-119 (347) alignment
Range on Protein: 80-154
Range on HMM: 37-119/347.0
EAGKNRYKDVGCLDNNRVKLEgP---------WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
.  ||| |||   |. || |  |          .. || | ..      | .| || || .|  ||| | .  ||  .  . . 
slsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 251-321 3.1e-07 24.0 In-house 265-346 (349) alignment
Range on Protein: 251-321
Range on HMM: 265-346/349.0
KGPIVVHCSAGIGRTGSVVMLEYIMDqlL------------AGQIIDDGEKILV-KICEQRNNSIQTDAQYLFVHQVILNYFRK
  ...|||||| |||| .| |.....  .              ..  |   | | ..  || . .|  ||. .... .|.||. 
lstllvhcsaGcGrtGvlvtldllls..ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfal

subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 93-213 3.2e-07 22.2 In-house 58-178 (327) alignment
Range on Protein: 93-213
Range on HMM: 58-178/327.0
DNNRVkLEGPwPHEYIHANYVATptNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLE---KGAKKCFEYFPSKKGDVMDFDEGGQKISVKCES
|| || | |    |..  .||    .   .|  ||| .|.    | .  .|..  .  ||   .       ||. |||..  . |. .     .|. |..
dnrrv.lcgs.deeffpgqyvrm..egaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsivcka

SVTYSFRAD-AKANVTATEIVIEGP
    |. |   . ..| .|.||.  
reglsmgatkyeleltdsevvidkn

subfamily_CDC14_pd Subfamily CDC14 236-277 4.3e-07 24.1 In-house 248-288 (328) alignment
Range on Protein: 236-277
Range on HMM: 248-288/328.0
ADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
 |. | ..|| |  ..| |.||| ||.||||...   |.| .
sdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkh

subfamily_DSP1_pd Subfamily DSP1 227-277 6.9e-07 23.5 In-house 71-120 (163) alignment
Range on Protein: 227-277
Range on HMM: 71-120/163.0
DWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
| |.  . .  . |.| ..... ..| . .|| ||| |  ..... |.| .
DspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla.ylmkt

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 95-169 1.2e-06 22.9 In-house 8-72 (130) alignment
Range on Protein: 95-169
Range on HMM: 8-72/130.0
NRVKlegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfEYFPSK
.|..      ..||.|..|    . . .. ||.|| .|. ||| |  .  |. . .|    |.      ||.|  
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds

subfamily_DSP8_pd Subfamily DSP8 240-280 2.3e-06 21.3 In-house 82-121 (159) alignment
Range on Protein: 240-280
Range on HMM: 82-121/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQLLA
 .| .. |. ..| ..||. ||| |  .|. . ||| .|  
svefidkaksengrvlvhvlaGisrsatva.iayimktlem

subfamily_DSP6_pd Subfamily DSP6 241-278 4.8e-06 20.2 In-house 83-119 (158) alignment
Range on Protein: 241-278
Range on HMM: 83-119/158.0
LELLENARPSKGPIVVHCSAGIGRTGSVvMLEYIMDQL
.|....|| .|  ..||| ||| |.  | .| |.| .|
iefidearskkskvlvhClaGisrsvtv.tlaylmkkl

Y_phosphatase3 Tyrosine phosphatase family 218-271 6.3e-06 21.3 Pfam-A 95-144 (164) alignment
Range on Protein: 218-271
Range on HMM: 95-144/164.0
RKTTHYHWNDWPDRGvPAADMAVLELLENarpSKGPIVVHCSAGIGRTGSVVML
... . . .. ...   .|  .|||.| .   ..||...||.||  ||| |..|
eeamaeayreilede.kkayrkvlealae...eegpvlfHCtaGKDRTGvvaal

subfamily_DSP10_pd Subfamily DSP10 240-277 8.1e-06 19.8 In-house 81-117 (159) alignment
Range on Protein: 240-277
Range on HMM: 81-117/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQ
 || .|.|| .   ..||| ||| |  .|| . |.| .
alefieearkkgsrvLvhCqaGisrsatvv.iaYlmkh