Synonym: CELE_F10G8.1, F10G8.1
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 33-338 | 1.7e-199 | 655.9 | In-house | 1-305 (305) | alignment | ||
Range on Protein: 33-338
Range on HMM: 1-305/305.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
|.|||||||||||.|||||.|.|||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt
CADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG
||||||||.|||||.||||||.||||||||.|||.||..||..|.|.|||||||.|||||..||.||||.||.|..||||||||.||.|||||.||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg
VPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESgVQE
|||||.|.|||||.||||||||||||||||||||||||||||.|||||||||.|..|||.||.|||||||||||||||||||||||||||||.||. |.|
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee.vke
AYDAFL
||.|||
aykafl
|
|||||||||
0050432 | (Phosphotyrosine protein) phosphatases II | 32-323 | 8.1e-80 | 263.7 | In-house | 22-303 (308) | alignment | ||
Range on Protein: 32-323
Range on HMM: 22-303/308.0
VERKQQKKQILKFVQRtlEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLegPWPHEYIHANYVATP--TNPKRFICTQAPL
. |. ...||.... . ...|..|| .... . ....... . ||||||. ..|..|||| . .. ||.|.|| .. .|..||.||.||
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPl
EKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG-DVMDFDeggqKISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWND
..|..||| |... .|..| ||... |.| .||..|.|.. | ... .. |..|.. | . ....| ... .. ....|. ||.|. .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfhytn
WPDRGVPAADMAVLELLENARPS--KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
||| ||| ..|..|| .| | .||||||||||.|||| ...|.....|| ... .| .... |. |||....|| ||||.....| |...|.
WpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd.vfeavkklReqRpgmvqtpeqylflyralleylklkl
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 43-322 | 1.4e-79 | 262.3 | In-house | 5-280 (307) | alignment | ||
Range on Protein: 43-322
Range on HMM: 5-280/307.0
KFVQRTLEKMPQGLRAEFVGMRRFNDF-EKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGP-WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
.|||||.| | |. || . . . ..||. .. ||||.|| | |..|. .. . .||||||. . ..||.|||.| |||.| .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama
YQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTYSFrADAKANVTATEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAV
|.||| . |||. .| . || .|.| ..|. . | | .. |||. . . . . |||. ... ..|.| .|. |..||||||| ...
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklap.dedlinvttlkvdw...aqksrtiqhlqwenwpdrgvpqinlta
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
..||| | . |.|||||||.||.|..| . ...|...||. | .|.. .. .||. .|||.||||..|.|.|.|| ..
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflel
|
|||||||||
0040438 | (Phosphotyrosine protein) phosphatases II | 39-325 | 3.7e-79 | 261.6 | In-house | 3-281 (317) | alignment | ||
Range on Protein: 39-325
Range on HMM: 3-281/317.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCAD
...|..... | .. ..|. || ..... .. .. . .||||.|. ..|..|||| . . . ||.|.|| .| ...||.||.||..|..|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved
FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|..| ||... |.| .||..|.|. |... ... ..|.. | .. .|..| ... .|. ....|. ||.|. .||| |||
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygd....ftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvp
AADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFrKKKLM
.|..|| .| . .||..||||||.||||..........|| .. . | |... .. |||....|| .|| |.....|.|. |.||.
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleyl.krklt
|
|||||||||
0036941 | (Phosphotyrosine protein) phosphatases II | 53-324 | 3.1e-77 | 255.1 | In-house | 12-282 (297) | alignment | ||
Range on Protein: 53-324
Range on HMM: 12-282/297.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|. || . .. ...... . ||||||. ..|..|||| .. .. ||.|.|| .. ...||.||.||..|..||| |... .|. | ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt
NFLEKGAKKCFEYFPSKKGDVMDFdeggQKISVKCESSVTYsfradAKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP--
.. |.| .||..|.|...|... . ...|.. | .. ....| ... .. ....|. ||.|. .||| ||| .|...| .|
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl
----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA--GQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKL
|.||..||||||.||.|..........|| . | ... |. |||....|| ||.|.....|....||..
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 37-319 | 5.4e-77 | 254.4 | In-house | 6-286 (288) | alignment | ||
Range on Protein: 37-319
Range on HMM: 6-286/288.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTC
. ...||.|...| . . ||..|| ..... ...|.. . ||||.|. ..|..|||| . .. ||.|.|. .. ....||.||.||..|.
sveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv
ADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-----PGEKTRKTTHYHWNDW
.||| |... .|..| ||... |.| .||. |.|. |... ... |.|.. | .. ....| ... .. .....|. ||.|. .|
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnw
PDRGVPAADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|| ||| ..|..|. .| . .||.|||||||.|||| ...|.....||.... .| .... ...|||....|| ||.||....| |.
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.vleavkrlreqRpgmvqtpeqyrfvyealleyl
|
|||||||||
subfamily_Cele-PTP-10_pd | Subfamily Cele-PTP-10 | 37-322 | 4.3e-76 | 250.5 | In-house | 7-292 (305) | alignment | ||
Range on Protein: 37-322
Range on HMM: 7-292/305.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMK-AFKEAQE----AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNP-KRFICTQAPLE
. . .||.|.|. . || || |. .. . . ||. | ||||.|| | |.. |||. | | .||||||| | | |||||.| ||.
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld
KTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGgqkISVKcESSVTYSFRADAKANVTATEIVIEgpGEKTRKTTHYHWNDWPD
.| .||.| |.||| | |||. .| | || .|.| .|. ... | | |. . | . . ||. ..| .. |... | .|..|||
qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg...ivve.nvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpd
RGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|||| . .. |||| | || ||||||||||||||..| .|||.... . ... . .|| |||.| ||||.|.|.|||| .|
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 55-323 | 6e-76 | 250.8 | In-house | 1-278 (284) | alignment | ||
Range on Protein: 55-323
Range on HMM: 1-278/284.0
GLRAEFVGMRRFNDFE--KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATP-----TNPKRFICTQAPLEKTCADFWYMCYQD
||..|| ..... . ...... . ||||||. ..|..|||| . . ..||.|.|| .. ..|.||.||.||..|..||| |...
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq
KVEYIFMLCNFLEKGAKKCFEYFPSKkGDVMDFdeggQKISVKCESSVTysfraDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLEL
.|..| ||... |.| .||. |.|.. |.|. . ...|.. | . . |. |.. .|.....|. ||.|. .|||.|||. .||.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef
LENARPS------KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQI--IDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
|. .| . .||||||||||.|||| ...|.....|| .... | .... ...|||....|| .||.||....|.|...|.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
|
|||||||||
DSPc_SM00195 | 59-319 | 2.7e-75 | 248.4 | In-house | 5-262 (263) | alignment | |||
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
|| ... . .... .. .. |||||.. . |..||||. . ...||.|||. .....|..|.||.||..|..||| |... ||..| ||...
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee
EKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYSfradakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|. |||||. . ... .... ... .. | |.|||.|.|....|||.||| . |||||. .. |
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts
KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ... .| ..|. .. .|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
PTPc_SM00194 | 59-319 | 2.7e-75 | 248.4 | In-house | 5-262 (263) | alignment | |||
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
|| ... . .... .. .. |||||.. . |..||||. . ...||.|||. .....|..|.||.||..|..||| |... ||..| ||...
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee
EKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYSfradakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|. |||||. . ... .... ... .. | |.|||.|.|....|||.||| . |||||. .. |
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts
KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ... .| ..|. .. .|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
|
|||||||||
0047943 | (Phosphotyrosine protein) phosphatases II | 53-319 | 3.7e-74 | 244.9 | In-house | 11-272 (273) | alignment | ||
Range on Protein: 53-319
Range on HMM: 11-272/273.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|..|| .... . ...... . ||||||. ..|..|||| |. .. ||.|.|| .. ...||.||.||..|..||| |... .|..| ||.
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt
NFLEKGAKKCFEYFPSKKGD-VMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-
.. |.| .||. |.|.. |. .. ... ..|.. | | |...| ... .. ...|. ||.|. .||| |||. .||..| .|
elvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka
-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|.||.|||||||.||||....|....||| ... .| .... ....|| ...|| ||.|.....|.|.
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
|
|||||||||
0045450 | (Phosphotyrosine protein) phosphatases II | 37-321 | 5.6e-74 | 244.9 | In-house | 10-306 (307) | alignment | ||
Range on Protein: 37-321
Range on HMM: 10-306/307.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFND--FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYV--------ATPTNPKRF
. ...|..|...| . ..||..|| ...... ...... . ||||||. ..|..|||| . . . ||.|.|| .. ....|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf
ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG--PGEKTRKT
|.||.||..|..||| |... .|..| ||... |.| .||..|.|.. |... ... . |.. | . ....| . . .. . ...|.
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrtv
THYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKICEQRNNSIQTDAQYLFVH
||.|. .||| ||| .|...| .| ..||..||||||.||||..... ....|| ..... | .... .. ||| ...|. || |..
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly
QVILNYFRK
...| ...|
eallelllk
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 82-317 | 7.2e-71 | 233.7 | Pfam-A | 3-235 (235) | alignment | ||
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEgg
||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||.. ||| .|| .|.|..... . ...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..
qkISVKCEssvTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
|.|... . . ..... ... .|. .. ...|.....|...|||.|||. ..|.|... . || ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
QLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |.. | .|. .. .||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 82-317 | 7.2e-71 | 233.7 | In-house | 3-235 (235) | alignment | ||
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEgg
||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||.. ||| .|| .|.|..... . ...
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..
qkISVKCEssvTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
|.|... . . ..... ... .|. .. ...|.....|...|||.|||. ..|.|... . || ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille
QLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |.. | .|. .. .||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
|
|||||||||
0043336 | (Phosphotyrosine protein) phosphatases II | 39-319 | 1.3e-70 | 233.4 | In-house | 5-277 (278) | alignment | ||
Range on Protein: 39-319
Range on HMM: 5-277/278.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDfEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCAD
|..||.... | .....|..|| ...|. . .. .. . ||||||. ..|..||||. .. ||.|.|| .. |..||.||.||..|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved
FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPskkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|. | ||... |.| .||..|.| |... ... ..|.. . . ....| . . .. ..|. ||||. .||| |||
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvp
AADMAVLELLENARP----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.|..|. .| |.||..||||||.|||| ...|.....|| .. .| |... .. ||| ...||. || |.....| |.
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl
|
|||||||||
0039614 | (Phosphotyrosine protein) phosphatases II | 54-322 | 2.9e-69 | 229.1 | In-house | 32-292 (297) | alignment | ||
Range on Protein: 54-322
Range on HMM: 32-292/297.0
QGLRAEFVGMRRFNDfEkMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYI
..|..|| . .... . .. .. . ||||||. ..|..|||| .. . ||.|.|| .. ...||.||.||..|..||| |... .|..|
tllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi
FMLCNFLEKGAkKCFEYFPSKKGdvmdfD--EggqkISVKCESSVTysfradaKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
||... |.| ||..|.|.. | . ..|.. . . ....| ... .. ....|. ||... .||| ||| .||.||
vmLtklvelgr.kcaqywpeegg.....tygd....ftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflel
ARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
.| ..||..||||||.||||..... ....|| .. .| .... .. |||....||. || |.....| ....|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 80-321 | 8.3e-66 | 217.4 | In-house | 11-248 (249) | alignment | ||
Range on Protein: 80-321
Range on HMM: 11-248/249.0
EAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDF
||||.|. ..|..|||| .| ... ||.|.|. .. ..|||.||.||..|..||| |... ....| ||... |.| .||..|.|. |... .
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley
deggQKISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVV
...|.. | . |...| ... .. ..|. .|... |||| ||| .|...| .| ..||..||||||.|||| ..
....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi
MLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.. ....|| . .| | .. .. .||....|.. || |.....| ...|
aaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk
|
|||||||||
subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 35-325 | 4.2e-65 | 214.2 | In-house | 8-289 (290) | alignment | ||
Range on Protein: 35-325
Range on HMM: 8-289/290.0
KQQKKQILKFVQRTLEKMPQGLRAEFVG-MRRF--NDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATpTNPkRFICTQAPLEK
| . . || . .| ...| |.. .. . .. . | | . | ||||||| | | || |. . .|.||||| ... || || .|..
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG.lka.mfiltqGalkd
TCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESSVTysfrADAKANVTaTEIVIEGPGEKTRKTTHYHWNDWPDR
| |.| | |.|| .| |||. .|.| || .|.| |.|.|. | | |.| | . . ||. | | . | | |.. |||.
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe....itvlcseedd....kdaniikk.tlsvrdkdsGkehklkhlkikswpdk
GVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLM
|. ...|.| .| | ||.||||||||||||. | .| .. || |. .| . . . . | ||.| | ||| . ...|.. .. | .
svalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlld.lvralrnsrlnsvqvdiqylalveilldlGkdfkyi
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 78-322 | 3.6e-63 | 208.9 | In-house | 31-275 (278) | alignment | ||
Range on Protein: 78-322
Range on HMM: 31-275/278.0
AQEAGKNRYKDVGCLDNNRVKlegpwphEYIHANYVATPtnPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFD
. ||||||. ..|..||| .||.|.|. .. ||.||.||.||..|.|||| |... ....| ||....|.| .||..|.|. |... ..
lgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltyg
EggqkISVKCESSVTYsfRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--MAVLELLENARP-----------------SKGPIVVHC
. ..|...| .. . . | . .| .. ..|. ||.|. ||| ||| . . .||||| | |.||..|||
d....ftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC
SAGIGRTGSVVMLEYIMDQLlaGQIIDdGEKILVKICEQRNN-SIQTDAQYLFVHQVILNYFRKK
|||.|||| .|.. .....| .. .| .... .. .||.. ..|. || |.....| .....
saGvgRtGtlvaaylmlell..eggvd.lleavkelrsqRpglavqnleqyrflyefllelllrg
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 79-320 | 6.2e-63 | 207.8 | In-house | 8-244 (245) | alignment | ||
Range on Protein: 79-320
Range on HMM: 8-244/245.0
QEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMD
||||.|. ..|..|||| . . . ||.|.|| .. ...||.||.||..|..||| |... ....|.||... |.| .||..|.|. |...
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt
FDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
... ..|.. | . ....| ... .. . ..|. .|||. .||| ||| . .|..|| .| |.||..||||||.|||| ..
ygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi
MLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. ....|| . . .. |... .. .|| ...||. || |.....|....
aaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallellk
|
|||||||||
subfamily_PTPRD_pd | Subfamily PTPRD | 41-321 | 8.4e-60 | 198.0 | In-house | 10-283 (564) | alignment | ||
Range on Protein: 41-321
Range on HMM: 10-283/564.0
ILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAqEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFW
. ..|.. . . . |. ... . |.. .| |.| ||||... |..||.| || .|| |... . ...| .| ||.||..|..|||
lkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW
YMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGdVMDFdeggQKISVKCESSVTYSFRADAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPAAD
|... ... | || . ||| .|| .|.|.| | . ... |. |...... . ... .. ...|. ...|. .|||.|||
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety....geltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgvpesa
MAVLELLENAR----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
..|.|... | | .||||||||||.|||| . ........ . . .| ... .. .||| .|| || |.|..||.. .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDi.yqyvkalrkqRnamVqteeQYiFiheailealac
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 75-319 | 3e-59 | 195.8 | In-house | 5-242 (243) | alignment | ||
Range on Protein: 75-319
Range on HMM: 5-242/243.0
FKEAQEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPtnpKRFICTQAPLEKTCAD----FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPskk
.. . ||||.|. ..|..|||||| . ||.||.. . .|.|.||.||..|..| || |... ....| ||... |.|..||..|.|
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...
GDVmDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG--PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR------------PSKGPIVV
|.| ... ..|.. |. . ....| .....| ... || .|||. ||| ||| .|..|. .| .|.||..|
gev.tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV
HCSAGIGRTGSVVMLEYIMDQLlaGqiiDDGEKILVKICEQRNN-SIQTDAQYLFVHQVILNYF
|||||.|||| .... .....| | | |... .. |||.. ..|| || |.....| ..
HCsaGvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeallell
|
|||||||||
subfamily_PTPRB_pd | Subfamily PTPRB | 36-323 | 7.2e-59 | 194.2 | In-house | 7-289 (293) | alignment | ||
Range on Protein: 36-323
Range on HMM: 7-289/293.0
QQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
..... ..|... .. .. |. .. .. ...|| ..|... ||||... |..|||| .. .|| |||. . |. || || || .|
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet
CADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgdvmdfdeggQKISVKCESSVTYSFrADAKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRG
||| |....|.. | || . .||| .|| ||.|.. .. . . .|| . . . . |. || ....||...||. ||| |
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...........eepvlyGdikvtlva.eeeledwvirelkiek.ekeerkvrqyhftsWpdhg
VPAADMAVLELLENAR------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
|| . ..|..... | ||.|||||||||.|||| . |. ..... ...| |.... |.||. .|| .||.|.||..|...|||.
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi.fgivaelReeRnllvqtekqYifihqcvldllrkke
|
|||||||||
subfamily_PTPN9_pd | Subfamily PTPN9 | 40-324 | 1.3e-55 | 183.6 | In-house | 2-295 (297) | alignment | ||
Range on Protein: 40-324
Range on HMM: 2-295/297.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.| ..|. || .||. |.. .|. . ...|.| . ||||.|| |.|. ||.|. . .||.||.| ..| || || ||.||. ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf
WYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYsfrADAKanvtATEIVIE-GPGEKTRKTTHYHWNDWPDRGVPA
| | ....| | | ..|.| || .|.|........| ..||. . ... | | . ..|. |..|| ||. ||| |||
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvsnveveee...edyk....vrvleiknvkteesrkvthfqflsWPdyGvPs
ADMAVLELLENAR-----------------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
. ...|..||..| ||. |||||||||||||| . |.. ...| . .| . . .. .|| ||||. || | .. .|.|
saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvv.etvkllrtqrafsiqtpeqyefcylavley
FRKKKL
..|
alelka
|
|||||||||
subfamily_PTPN12_pd | Subfamily PTPN12 | 63-322 | 1.3e-55 | 183.3 | In-house | 24-280 (290) | alignment | ||
Range on Protein: 63-322
Range on HMM: 24-280/290.0
MRRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHE---YIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGA
... . ... .. .. .. ||||||. |..||.|. .| || ||.. .......| .|.|| || ||| | .. .|| . |.|. .| |
ykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk
KKCFEYFPSKKGDVMDFDEggQKISVKCESSVTYSFRADAkANVTATeiviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----KGPIV
||| |.|..... . |.| ..... | |. | . .|.| ...|| . .|...|||.|||.. .|||.|..| . |.|
kkCerYWpeegeeelefge..fevtleeekavdddflirt.Lkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlv
VHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDG--EKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
||||||.|||| .. ..|. ..| |..| .. ...... .||. .|| || .|.. ......|.
vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 71-324 | 2.2e-55 | 182.7 | In-house | 36-276 (288) | alignment | ||
Range on Protein: 71-324
Range on HMM: 36-276/288.0
KMKAFkeAQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKK
...| ... ..||... . | ||||. |. ||.|| |.. ...|.||.||||. | .| | . |||| |||..|||| .| ||||||.
iidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl
GDVMDFDEGgqkisvkceSSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
|. . . .|. ||| . |. . . |. .||.. . |...|.| ||| .. | ||| . . |||||.|||.|||| ...
Gekarigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlil
LEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKL
....| . ...| | |.| ..||| |||.||...|... ||
ilialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvleelllkky
|
|||||||||
subfamily_Urchin-PTPRB-like_pd | Subfamily Urchin-PTPRB-like | 43-331 | 1.2e-53 | 177.0 | In-house | 10-285 (288) | alignment | ||
Range on Protein: 43-331
Range on HMM: 10-285/288.0
KFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
. |... . .|. |. . .. .. .| ..|. | ||||... .| .||||.. .|| |.|.. . |..|.||.|| .| ||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel
CYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmDFdeGgqkisvkcesSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMA
|..|.. | || ...|.| .|| ||.|... . . | ||| . . . . . .. .. . .. ...|.|.. ||| |||.. .
vyenktstivmltelveggktkCeeYWPdadkpk.ny..G..........svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskap
VLELL---ENARPSK-GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILnyfrkkKLMDESGVQ
.|||| ..| ... |||.||||||.|||| . |. ..|.. . . || . .. |. .||.. .|| || |...|.| .|..| ||.
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevll......slieedgva
|
|||||||||
subfamily_PTPN3_pd | Subfamily PTPN3 | 59-321 | 5.5e-53 | 174.7 | In-house | 20-277 (280) | alignment | ||
Range on Protein: 59-321
Range on HMM: 20-277/280.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPhEYIHANYVATPTNP----KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
.| . | . ...| . .... ||||.|. |. ||||. .|| |||| . .|.| || ||.||..|||.| ...|.. | || .
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl
LEKGAKKCFEYFPSkKGDVMDFdeGgqKISVKCESSvtysfraDAKANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK--
.|.| .|| .|.|. ..| ... | ..|||||.. |.. .. |.|.. .. || .. . .||| ||| .||..|. | .
verGrvkChqyWPe.tedeley..g..efsvkceke.......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg
--GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|.|||||||||||| ...|| . . | . . .|. .. .|| . .|| .|| || . ||. ...
keePvvvhCsaGigrtGvlilletalalieaaepvyp.ldivrtmrdqramlvqtasqykfvCeailkvyee
|
|||||||||
subfamily_Sponge-PTP8_pd | Subfamily Sponge-PTP8 | 53-320 | 3.2e-52 | 172.6 | In-house | 21-284 (305) | alignment | ||
Range on Protein: 53-320
Range on HMM: 21-284/305.0
PQGLRAEFVGMRRFNDfeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.|| |.. . . .. ... |. ... |||.|.. ||..|..| ..|| |.|| . . |..| .|.||..| ||||.. .. ||. |
dkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv
MLCNFLEKGAKKCFEYFPSKKGDVMDFdeggQKISVKCESSVTYSFRADAKANVTATEIviegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN---
||.. | | .|| |.| .|.....| ...||. .|. |.| | ... . ...| ..|. |||| ||| ..|.|...
mltklveggkdkCrqYWpesktekkef....gefsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk
-ARPSKG-PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
. .|| |..||||||.|||| .... ...| . ...| ..| .. ..| . .|| .|| |.|... ..
dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdv.fevlkqlRskrmkmvqtldqYvflhdaldelit
|
|||||||||
subfamily_PTPN6_pd | Subfamily PTPN6 | 38-325 | 8.5e-52 | 171.0 | In-house | 10-303 (306) | alignment | ||
Range on Protein: 38-325
Range on HMM: 10-303/306.0
KKQILKFVQRTLEKMPQGLRAEFVGMRRF---NDFEKMKAFKeAQEAGKNRYKDVGCLDNNRVKL-EGPWPH-EYIHANYVA--TPTNPKRFICTQAPLE
.... .. . . .. .|. || ... . ...... | .. . ||||| . |..||.| | | .|| |||. .... |..| || ||
eqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle
KTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMdfdEGGQKISVKCE-SSVTYSFRADAKANVtateivieGPGEKTRKTTHYHWNDWP
.| .||| | .|.. . | |. . .|.| .|| |.|... . . | ... | | .| .| ... ....|. .||...||
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskk........kkkkeerevfqyhfksWP
DRGVPAADMAVLELLENAR--------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
| |||. |||..||. . ..|||||||||||||||...... ..... . | .|. .. |||. .||..|| ||...| .|
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
RKKKLM
..|| .
etkkkl
|
|||||||||
subfamily_Cele-PTP-19_pd | Subfamily Cele-PTP-19 | 81-312 | 2.5e-50 | 166.0 | In-house | 51-274 (301) | alignment | ||
Range on Protein: 81-312
Range on HMM: 51-274/301.0
AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFdeGG
|.||. | | . |.. ||||.. |. .|.|||.||.||..|. ||| |. | .|| | ||....|| .|| ||.|.| .. .| |
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi..gr
QKISVKCESSVTYSFRADAKANVTATEIVIegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA
|| .| . .. . .|. . . .|| ||| ...|.||||| . . . .|.| .. |. ||||||||||||. . . ||. ...|
fkikiknkelilnkkiskrtlevedstgkf.....atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea
GQIIDDGEkILVKICEQRNNSIQTDAQYLFVH
. |. | | .. |.| |..|| | ..
dptielte.alkhlrehrwngvqtnsqlywmt
|
|||||||||
subfamily_Anemone-PTP-2_pd | Subfamily Anemone-PTP-2 | 33-319 | 3.6e-50 | 165.9 | In-house | 6-290 (298) | alignment | ||
Range on Protein: 33-319
Range on HMM: 6-290/298.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFND---FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQ
| .. |... |... . .| |. .|| ... .. |.... .. . |||| |. || || || .|| | .. . .. . || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq
APLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDfdeggqKISVkcessvtYSFRADAKANVTATEIVIE-GPGEKTRKTTHYHW
|||..| .||| | ..... | || | |.. |. .|.|... . . .|.| . . .|... ... .. ||.|. . |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg......eitv.......sllskeefadlivrklkvskkkeekerevrqlhf
NDWPDRGVPAADMAVLELLENARPS---KG--PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||.|||. .||.||.. | | | |..|.||||.||.|. . .. ..... . | .| ... . ..| ...|| .|| |.....|...
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDv.fqvvkvlRkkrpgavqteeqYvfiyeavleal
|
|||||||||
subfamily_Choan-PTP-1_pd | Subfamily Choan-PTP-1 | 44-322 | 3.9e-50 | 165.5 | In-house | 5-279 (281) | alignment | ||
Range on Protein: 44-322
Range on HMM: 5-279/281.0
FVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
.... .. .|. |. ... . . .| |. . ||||... |. |||. | .|| ||.|.. ...|..| ||.|. .....|| |
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv
YQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdvmdfdeggqkiSVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAV
.. ||. | |. . .|.| || |.| .. ..| . | .. .||. .. .| . .||. .. .. ||| |||| ...
weqkvsaivmvtreieagklkChrYWPddns............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkel
LELLENA----RP-SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|| .. .. .| |.|.|||||.||||. . |. ..... | . | . .. .. ..|| .|| .|| ||....|... |.
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
|
|||||||||
subfamily_PTPN23_pd | Subfamily PTPN23 | 81-321 | 7.3e-50 | 164.4 | In-house | 44-282 (288) | alignment | ||
Range on Protein: 81-321
Range on HMM: 44-282/288.0
AGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVA--TPTNPKrFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDE
. |||..|. |.|||||.| .|| | .| .|. |. ||.|||||..| .||| | |..|.. | || . |.| .|. .|.|..||. . |..
seknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd
ggqkISVKCESSVTYSfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--------RPSKGPIVVHCSAGIGRTGSVVM
.|| ..| . . | . .. . ..... .| ... ||. ||||. .|..|... |.|| |.|||||||.|||| . .
....lsvtlksvrete......thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal
LEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
. .. .| .|... | ... ...||| ...|. .|. |. ...|.. |.
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
|
|||||||||
subfamily_Anemone-PTP-6_pd | Subfamily Anemone-PTP-6 | 51-321 | 8e-50 | 164.7 | In-house | 17-282 (318) | alignment | ||
Range on Protein: 51-321
Range on HMM: 17-282/318.0
KMPQGLRAEFVGM-RRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVE
. | .|. . | . . ..|. | . |||| .. |. ||||. | .|| |||. .. | .| .|||| .|. ||| | .. .
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa
YIFMLCNFLEKGAKKCFEYFPSKKGDVMDfdeggqKISVKCESSVTYSFRADAKANVTATEIviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
| || . |.| .|. |.|||. .. |. |. ...|..| . .|| || |..|. ||. .|||.|||. . .|.|. .
vivmltqeeergkakvhryWPskgsrsyg......klvvelkeevelsdyvlrefkvtrtee......eesrqvrqyhytsWpdegvpesgaslldlvrq
A-----RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
. ....||||||||||.|||| .... ..... | ...| .. .. |||| .||. || |...|.|..
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvllealas
|
|||||||||
subfamily_PTPRG_pd | Subfamily PTPRG | 54-343 | 8.5e-50 | 164.5 | In-house | 19-314 (563) | alignment | ||
Range on Protein: 54-343
Range on HMM: 19-314/563.0
QGLRAEFV--GMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEY
.|. .|| .. .. .... .. .. |||| .. |. ||||.. ..|| |||. | || || ||..|. ||| | .. .|.
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai
IFMLCNFLEKGAKKCFEYFPSkkGDVMDFDeggqKISVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE--
| |. |. |.|..||. |.|. ...... ...|. ... . . . . . ... . .. .. ..||. .||| ||| . || .
ivmitnlvergrrkcdvYWPk..desetyg....alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks
-NARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK--KLMDEsGVQE--AYDAFLE
|... ||||||||||.|||| ..|. .. |. . .... ..| .| |||. .|| ||.|.|...|. . | .|..| |.| .||
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavn.vfgflkhiraqRnflvqteEqYiflhdalleaiasketellae.qveelknctpyle
QYKK
| |
qqyk
|
|||||||||
subfamily_Ptp69D_pd | Subfamily Ptp69D | 54-322 | 9.9e-50 | 164.4 | In-house | 22-289 (307) | alignment | ||
Range on Protein: 54-322
Range on HMM: 22-289/307.0
QGLRAEFVGMRRFnDFEKMKAFKEAQ-EAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.|| |. . . ..| . | . | ||||.|. |..||||. | .|| |... . . |.||. |.|.| | ||| | . .|. |
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv
MLCNFLEKGAKKCFEYFPSKkgDVMDFDeggqKISVKCESSVTYSFRADAKANVTATEIViEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--
|| | || ||| |.| | . .. .| ||. |. . | . . .|. .. | |..|| . ||.. |.| || . ..|.|.|..
mlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkee.sgevedsrkvvqyhytgWkDskvPevargllklieqvre
--RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
. ...||||||||| ||.| .| |. ...|| | . .| | . .. .||| .| .|| |... .|.| .
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife.tvkdLrsqRnllvqsleqYvflyralldyssyg
|
|||||||||
subfamily_PTPN5_RR_pd | Subfamily PTPN5_RR | 54-321 | 1e-49 | 164.1 | In-house | 5-270 (274) | alignment | ||
Range on Protein: 54-321
Range on HMM: 5-270/274.0
QGLRAEFVGMRRFNDFEKMKAFKeaqEAGKNRYKDVGCLDNNRVKLEGPWPH----EYIHANYVATPT-NPKRFICTQAPLEKTCADFWYMCYQDKVEYI
. |..||. . | |... |. .. |||||.. .| || || .. .|| |||. . . | .. || || .| |||| | ||..|. |
kdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi
FMLCNFLEKGAKKCFEYFPSKKGdvMDFDEGGQKISvkcessvTYSFRADAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENAR
|| .. |. .|| .||| ... .. .| .... . . . . ...|.. . .|. .|| . ||||. .| ..|.|... .
vmltklkeaneqkCavyfPdaed..yeiserygdve.......ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleve
P-------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.|.|||||||||||| . . . || . ...| || ... .| .||. || ..|... | ..
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclylkr
|
|||||||||
subfamily_Anemone-PTP-5_pd | Subfamily Anemone-PTP-5 | 45-321 | 1.1e-49 | 164.2 | In-house | 14-285 (319) | alignment | ||
Range on Protein: 45-321
Range on HMM: 14-285/319.0
VQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCY
... .. ..|. || .. ... ... .. . ||||... |. ||.| .| .|| |... . . ..|| ||||||.| ||| | .
lkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW
QDKVEYIFMLCNFLEKGAKKCFEYFPSKKgdvmdFDEGGQkISVKCESSvtysfraDAKANVTATEIVIEGPGEK--TRKTTHYHWNDWPDRGVPAADMA
.... . ||.. ||. |. .|.|... | |.|. . |. |. . .... .. .. .. ||. .|.....||| .|| ..
eeessivvmltklveklkvklkkywpeen.....feeyGr.livtleee.......eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats
VLELLENAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.|.||.. | ...||||||||||.||||. ..|. ..... ...| .. .. ||| .|. .|| |.....|..
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyealleavea
|
|||||||||
subfamily_Cele-PTP-14_pd | Subfamily Cele-PTP-14 | 74-338 | 1.8e-49 | 163.0 | In-house | 48-308 (310) | alignment | ||
Range on Protein: 74-338
Range on HMM: 48-308/310.0
AFKeaQEAGKNRYKDVGCLDNNRVKLEG--PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkG
|.| .. |||| || |||. ||||. ..||||||| | . |||.| ||..| ||| | .|.. | |..||. |.| || |.|| |
ayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.g
dVMDfDEGGQKISVKCESSVTYSFRADAKANVTATEIVIEGPGE-KTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
| . | ... .||| . | . | | | | . | . . .| .||||||| . |. .|| |||||||..|.. ||
.vte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvva
LEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESGVQeAYDAFL
|.. .|.| |. .| |.. .. .| |||. |||....| . . | .. . |. . . ||||
lklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifargetevaekill.ladafl
|
|||||||||
subfamily_PTPN1_pd | Subfamily PTPN1 | 72-335 | 7.5e-49 | 161.0 | In-house | 24-285 (290) | alignment | ||
Range on Protein: 72-335
Range on HMM: 24-285/290.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
... |. .. ..|||.|| | |.||| .|| |. | . ...| || || .|.. || | ...| . || ...||. ||..|.|...
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee
-DVMDFDEGGQKISV-KCESSVTYSFRADAKANvtateivieGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS------KGPIVVHCSAGIG
. . ... |. . . |.. .| | | ..||. .|.|. ||| ||| . | |..| . | | .|| |.|||||||
ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG
RTGSVVMLEYIMDQLLAGQI--IDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYfrKKKLMDESGVQEAYD
|.|...... .. .. . . | .| |... ..| ||| | | .. ||. |.....| ||. .
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG..akvikgdssvqkrwk
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 106-342 | 1.6e-48 | 161.0 | In-house | 5-248 (272) | alignment | ||
Range on Protein: 106-342
Range on HMM: 5-248/272.0
EYIHANYVATPTN---PKRFICTQAPLEKTCADFWYMcYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDF-DEGGQKISVKCESSVTYSFRADAKA
||.|..| .... |.|......||. |.||||.. .. .. .|..|.. |.|. ||. | | . .... |.. . |.. . . ..|.
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy
NVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADmaVLELLENARPsKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDD-------GEKILVKI
.. ..... . ...|. .|.|. ||||.||| .||||| . .||..||||||..||| ||.| ... .. . .|.|| |... ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel
CEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESGVQEAYDAFLEQYK
.|| ...||..||||.....|...|. .... .. |.||. |.|
raqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyG
|
|||||||||
subfamily_Choan-PTP-2_pd | Subfamily Choan-PTP-2 | 76-321 | 1.1e-47 | 157.2 | In-house | 16-266 (270) | alignment | ||
Range on Protein: 76-321
Range on HMM: 16-266/270.0
KEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVA-TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
. |... |||.|. . ||.|| .|| ||||. ..|..|....||. | .|| | .. ||. | |. .. ||| ||| |.|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk
DVMDFDEGgqKISVkcessvtYSFRADAKANVTATEIVIEGPGEKTRKTtHYHWNDWPDRGVPAADM------AVLELLENAR-----PSKG-PIVVHCS
. ... .| ||.| . . .|.. .| ||. | . |...|.|||.||| .. .|..|.. | .|. |..||||
ekvkledg..kikv.......lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs
AGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
||.|||| ...|.... | . . | .|. .. ..| . .|. || |.......| ..
aGvgRtGtlialDiavrlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveyaer
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 57-319 | 2.3e-47 | 156.5 | In-house | 14-269 (273) | alignment | ||
Range on Protein: 57-319
Range on HMM: 14-269/273.0
RAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPheYIHANYVATPTNPKRF--ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
|| .| . .. . |.... ||||..| |. ||||.. . || |... | . ... | .| || .|..||| | .. |.| | |. .
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle
LEKGAKKCFEYFPSKKGDVMDFDeggQKISVKCESSVTYSfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR---PSK
||| || |.|..|.. . ... |. . . .. . | . |.. ...|. .| .. .||| |||.. . .|... . | ..
kekgkvkchrywPesknkklkvs...nrlevellkvqkld......gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda
GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||||||||||||.|... .. ... . . .| ..|. |. |||. .||. ||.||...||. .
gPivvhcsaGiGrsGtlitidvvlglierdkefd.vkeivrklreqrqgvvqtkdqyifvykailevl
|
|||||||||
subfamily_Cele-PTP-13_pd | Subfamily Cele-PTP-13 | 71-321 | 5.3e-47 | 154.8 | In-house | 28-271 (281) | alignment | ||
Range on Protein: 71-321
Range on HMM: 28-271/281.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYF
.|.. . |||| .. ||| ||.|. | .||||||. .| . .| || | ..| |||| | .|.. | |||.||| .|| |||
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf
PSKKGDVMDFDeggqKISVKCESSVTysfradAKANVTaTEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTG
| . ...|| |.||. | | |. || | . . || || ||. |..||| || . .|..| . | | |.|||||.||.|
prnahcclqfd....klsvsyedstv......nkslvt.trlnlsyege.trlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsg
SVVMLEYIMDQLLAGQIIDDGEKILVKI-CEQRNNSIQTDAQYLFVHQVILNYFRK
... .| .. . . . | ..|. .. | |.|| ||... .|.|..
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
|
|||||||||
subfamily_PTPRA_pd | Subfamily PTPRA | 73-320 | 4.3e-46 | 152.3 | In-house | 51-296 (330) | alignment | ||
Range on Protein: 73-320
Range on HMM: 51-296/330.0
KAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
.. .. .. |||. .. | .|| | || .|| | .. . ..|| .| |.|.| ||| | .. | | || .. |. .|| |.|..
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde
kGDVmdfDEGGQKISVK-CESSVTYSFRadaKANVTatEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP----SKGPIVVHCSAGIGR
| | | ...|. .. .| |. | | |. .. . .|.| . .|.. ||| |||. . .|.||.. . | ||||||||||.||
.Glv...tyGnirvevedetvlvdytvr...kflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr
TGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFR
||. ..|. ..... | ...| | .. .. || . .||| || |...|.|.|.
tGtfivldavlervkaerkvdvfe.fvkrlrlqrpqmvqtdeqyefiykvlleyyl
|
|||||||||
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 40-344 | 4.9e-46 | 151.8 | In-house | 5-299 (312) | alignment | ||
Range on Protein: 40-344
Range on HMM: 5-299/312.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGPWpHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
| |. . || | |. . . || .. ||| .. | | | | | |||||.| |.|.||.|||.|||.||. || .
mikkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwql
CYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmDFDEggQkiSVKCESSVTYSFRADAKANVT--ATEIVIEGPGEKTrKTTHYHWNDWPDRGVPAAD
. | .|| |.| |..|| .| | | |... . | |. .| ..| .|. |... | || | ||| |.| .
alslgstsiillcgfvedgsekcakyisdivgfv.dled..h..rvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdsc
MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQiIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESgvQEAYDAF
. | || . | |.. |||||.||||.....| .. | . .. ...| . .| |... .||... ...|... | |. . .. . |
dtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn..eqewtkf
LEQYKKV
| | |.
ketyaki
|
|||||||||
subfamily_Nvec-PTP-2_pd | Subfamily Nvec-PTP-2 | 76-319 | 8e-46 | 151.3 | In-house | 5-242 (250) | alignment | ||
Range on Protein: 76-319
Range on HMM: 5-242/250.0
KEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKkCFEYFPSKKGD
|. |. |||| |. ||. || || .|| | .. . .. | || ||.||..| ||| | ...|.. | || |. |.. . . .|.| .| .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae
VMdfdeGgqKISVKCESSvtysfraDAKANVTATEIVIEGPGEKT-RKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTG
| .. |. |. . .|..| ..... .. | ..|. |||.|||. ||||||.. . ..|..|.||||.||.|
ky....G..dvtvsllsk.......eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG
SVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
. . .. ....| ...| |.. .. ..| ..... .|| ||...||..
afiaidavlerlkkekvvdv.fkvikvlrkdrphavesleqyvfvyeiilkal
|
|||||||||
subfamily_PTPRK_pd | Subfamily PTPRK | 69-317 | 1.6e-44 | 147.0 | In-house | 32-275 (314) | alignment | ||
Range on Protein: 69-317
Range on HMM: 32-275/314.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEY
|| | |. .. |||..|. |. ||.| .| .|| |... . ..|. || || ||..| .||| . |... | || .. |.|. || .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky
FPSKKGDVMDFdeggQKISVKCESSVTYSFRADAKANvtateivIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAG
.| . |. . |..| . | . . .. . |..|. .... ||| .|| ..|.|. . ...|.||||||||
WPedtevygdi....kvelvetellaelvvrifrvek.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaG
IGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILN
|||| .... ..| . ...| .. ...... | ..| || |...|||.
aGrtGtfiaidivldmieregvvdv.fnavktlrsrkvnmveteeqykfiydvile
|
|||||||||
0041856 | (Phosphotyrosine protein) phosphatases II | 82-323 | 9.3e-44 | 144.5 | In-house | 3-175 (182) | alignment | ||
Range on Protein: 82-323
Range on HMM: 3-175/182.0
GKNRYKDVGCLDNNRvklegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgakkCFEYFPskkgdvmdfdeggq
||||.|. . |..| . ||.||... . ..|||.||.|| .|.|||. | .. .. .| .|. .. |.|
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............
kisvkC-EssvtysfradakanvtateiviegpgekTRKTTHYHWNDWPDRGVPAaDMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQlla
. .| ..|.. ||| ||| .|...| .. ..||..||||||.||||..|.. ... .
.....ell............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...
gQiiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
. . |... . ..|.....| || |.....| ... ||
.g..vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
|
|||||||||
subfamily_Urchin-PTP-1_pd | Subfamily Urchin-PTP-1 | 71-321 | 1.1e-43 | 144.4 | In-house | 35-279 (315) | alignment | ||
Range on Protein: 71-321
Range on HMM: 35-279/315.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNfLEKGAK-KCFEYF
. .. .| .. |||||.. ||..||||| ..|| | |. . . | .|..|.||. . ||| | .|.|| | |. . ...| | || |.
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk.kqegdkikcrqyw
PSKKGDVMDFdeGgqKISVKcessvTysFRADAKANVTATEIvIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGI
| .|.| ..| | .|.|. . . .| .. .| .. . .|..|. | .....|||.||. ..|.|. . . ..| ...||||||.
Pdrkadsvef..G..sikve.....l..lsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGv
GRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|||| |. .. ...|. .. .| ... .. ..| .||. .| |.....|...
GrtGvvisidevvaqikrtrsvdvf.nfvknlrakrpylvqteeeyafiydavledllw
|
|||||||||
subfamily_Sponge-PTP11_pd | Subfamily Sponge-PTP11 | 42-321 | 4.6e-43 | 142.1 | In-house | 8-285 (290) | alignment | ||
Range on Protein: 42-321
Range on HMM: 8-285/290.0
LKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE-----GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.||. | .| |..| . .. .... .. .||.... |.||. | ..|||.| |. . |..| ||.|...| .||
gefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF
WYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgDVMDFDEggQKISVKCESSVTysFRADAKANVTATEiviegPGEKTRKTTHYHWNDWPDRG-VPA
| . .|.|| | ||.| |.| .|| |.|.. |. ...| .| . |.... | .|. .. ...... |.|. |.. | |..
WkliwqekvtiivmltniieegkvkCqqYWpds..dtkayge..fsikllneetln..eyierklevknkn.....sagakqsvtqyqitnwdstgkvtn
ADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.| . | .. ...||||||...||.. . .. ... . || ..| . |. .|.|| || ...|..|.|. .
pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidv.fqvlksqRiqkpgsvqtvqqyqgifqivltylds
|
|||||||||
subfamily_Urchin-PTP-6_pd | Subfamily Urchin-PTP-6 | 78-320 | 6.1e-43 | 141.7 | In-house | 41-277 (515) | alignment | ||
Range on Protein: 78-320
Range on HMM: 41-277/515.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVM
. |||||.. .|..||||| ..|. | |. . | | .|..|.|.. . ||| . .|..| | |. . | || .|.| | || .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv
DFdeGgqKISVKcessvTYSFRADAKAnVTATEIVIEgpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTGSVVM
| | .|.|. . | |.. . . . |. |...| | .|...|||.||| ..| |. . . ..| |...|||||.|||| |.
kf..G..sikve.....lvsleactgg.ikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis
LEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. .. . ....| ... .| ..| .||. || |.....|...
idsvvahakttrmvdvf.nfvtnirqkrpylvqtqeqyafiygavledll
|
|||||||||
subfamily_PTPN14_pd | Subfamily PTPN14 | 66-321 | 2.3e-41 | 136.7 | In-house | 35-298 (300) | alignment | ||
Range on Protein: 66-321
Range on HMM: 35-298/300.0
FNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW--PHEYIHANYVATP--TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKK
. .... | ..| |||.||| ..|||.| ..|| | . .. .. . .| .|.|||.|. ||| | ....|. | || . |.| .|
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek
CFEYFPSKKGDVMDFDEGgqkisvkcESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------------R
.|.|||... . | . || |. |... .| . . | .. |. | ..||||.||| |. ||. .
sfkyfPkleskkktvefg........kfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk
PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|| |..||||||.|||| ... . .. | .. || .|.| .. ||| .|| ||| ||..|...|...
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
|
|||||||||
subfamily_Sponge-PTP10_pd | Subfamily Sponge-PTP10 | 40-321 | 5.5e-41 | 135.4 | In-house | 6-280 (287) | alignment | ||
Range on Protein: 40-321
Range on HMM: 6-280/287.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEK-MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWY
.. .||.. .| .| . |. . . .. |. . | |||.... ||.|| |.| ..|| | .. . . |.|| ...|. .| .||
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk
MCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdV-MdfdeGGQKISVKCESsvTYsfradAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG-VPAA
. . .|. | |||. |. ..|..|.|..| | . | .|.. | .. |. . |. .. ..... . |. .|...| |.
liddrnvtaivmlcqekendeevcyqyWpeeks.vvl....Geyniellnee..vn.....agyierklevknknkagdkqqvkqyqitnWdstgkvtep
DMAVLELLE----NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.| . | . ......||||||...||.. . . ... .|| ..| . |. .|.|| .|| |. ...|.|
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleylds
|
|||||||||
subfamily_Urchin-PTP-7_pd | Subfamily Urchin-PTP-7 | 69-321 | 3.2e-40 | 133.0 | In-house | 38-281 (315) | alignment | ||
Range on Protein: 69-321
Range on HMM: 38-281/315.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEY
. .. |. .. |||| .. |. ||.| | .|. ||.. . ..|.|..|.|. . ||| . ..... | || | |. .|. .|
lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky
FPSKkgdVMDFdeGGQKISVKCESSV-TYSFRADakanvtatEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR----PSKGPIVVHCSA
.| | . . | .. | | |. |. .| |.. |. .|. ||| |||. .....| ... | |.|||||||
wpdk...kviy..Gkitvtrkseevnteytvrtl........svvf...gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa
GIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|.||||. . |. ..||. | ..|| ... .. ..| . .|. .|| |.....|. |
GvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalletfvc
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 82-329 | 6.1e-40 | 132.0 | In-house | 37-280 (285) | alignment | ||
Range on Protein: 82-329
Range on HMM: 37-280/285.0
GKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNP-KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGG
||| || |... || |. ..||||... | . .| || || .| .|||.| ||.|. |..||| ..| | .|| |.| | |.|. | .
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye
QKISvKCES-SVTYSFrADAkANVTATEIViegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELL---ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMD
.. .|. ... . .| |. || . | . |||. | ..|| .. | . ||.||||||.||| ..| ..|
itlt.eckeeaiagti.lna.ltvinteda....sseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati
QLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESG
... |. |. .. | ...|. |.||.. |...|| . ... .|
rimenpniem.ldivremramrfqavqshmqflflyvvlmeyfigegvvertg
|
|||||||||
subfamily_Anemone-PTP-4_pd | Subfamily Anemone-PTP-4 | 81-316 | 9.8e-40 | 131.2 | In-house | 4-236 (237) | alignment | ||
Range on Protein: 81-316
Range on HMM: 4-236/237.0
AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmdfDE
|||| .. . | .|| |.|. .|| |.|. ||..|..| ||| .| ||| | .|.| | || ..|. .|| .|.|| .
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ay
GGQKISVKC-ESSVTYSFRADAKANVTATEiviegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----AR--PSKGPIVVHCSAGIGRTGSVVML
| .|.| | |. |. .. . . . | |.. ||||||| |.| . | .. . || ..|||||.|||| ....
gvltvslkkkeefsdytvrslllskrltlk........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi
EYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVIL
. .. | ...| . . | |.| ||| ||.|.||.||
damlrqakekkvvdiyn.yvysieedrpyiiqtkdqyvfihqtil
|
|||||||||
subfamily_egg_pd | Subfamily egg | 65-341 | 2.5e-39 | 129.8 | In-house | 25-291 (307) | alignment | ||
Range on Protein: 65-341
Range on HMM: 25-291/307.0
RFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKgaKK
| . .. .. . | | | | | | ||||| | . ..||||.| ||..|||| | ||| | .|..|.|| || | ..
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er
CFEYFPSKKGDVMDFDEGGQKISvkCessVTYSFRADAKANVTATEIviEGPGEKTRKTTHYHWnDWPDRGVPAADMAVlelLENARPSKGPIVVHCSAG
| |.| . | . . |. .| . . .|| .|| . |. .. | |. . |. . . | | .| |.||.. |
ceyywpkaesdslvtvpGslrie..n...lkvdskadplfrvtklkl..vGgddeerflehwqg.dvnnssdvysplrv...lrklrnlskpvvvqdilG
IGRTGSVVMLEYIMDQLLAGQIIDDG-EKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKkLMDESGVQEAYDAFLEQY
. .....| .| . .|| | | . | . .|. |... .||||....| .|| . .. |. .||..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv.igsakeldvdyerwleer
|
|||||||||
subfamily_Urchin-PTPRA_pd | Subfamily Urchin-PTPRA | 78-318 | 2.6e-39 | 130.4 | In-house | 59-290 (319) | alignment | ||
Range on Protein: 78-318
Range on HMM: 59-290/319.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgAKKCFEYFPSKKgdvm
|. |||. .. |.|.|||| | .|| | .|. .....| .| ||. | |||| | .. .. | .| .|| .|.| |
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki....
DFDEGGQKISVKcesSVTYSFRadakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSV
. |. |..|. ||. . | |. .| . || | .|. ||| ||| . .. |... . .||||||||.||||
vikeerfkvkvd...sveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy
VMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
..|. ..|.. . .| ... . .|||. .| .|| |.. .|.
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysallee
|
|||||||||
subfamily_Urchin-PTP-8_pd | Subfamily Urchin-PTP-8 | 79-318 | 6.2e-39 | 129.2 | In-house | 24-254 (284) | alignment | ||
Range on Protein: 79-318
Range on HMM: 24-254/284.0
QEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgAKKCFEYFPSKKgdvmD
|. |||. .. |.|.|||| | .|| | ... .....| || ||. | |||| | .. .. | .| .|| .|.| | .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki....v
FDEGGQKISVKcesSVTYSFRadakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSVV
|. |..|. ||. | | |. .| .. || . .|. ||| ||| . .. |... . .||||||||.|||| .
ikeerfkvkvd...sveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi
MLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
.|. ..|.. . .| ... .. .|||. .| .|| |.. .|.
vldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysallee
|
|||||||||
subfamily_Sponge-PTP6_pd | Subfamily Sponge-PTP6 | 80-317 | 1.2e-38 | 127.7 | In-house | 48-277 (439) | alignment | ||
Range on Protein: 80-317
Range on HMM: 48-277/439.0
EAGKNRYKDVGCLDNNRVKL-EGP-WPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAkkcfeYFPSKkGDVMDF
. |||||||| .| || | | | || || |||. ..| .| ||.| ..|. ||| . .. |. | ||.|..| |.||. ..|.
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd.aevcyg
DeggqkISVKCESSVTYSFRADAKANVTATeiviEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----ENARPSKGPIVVHCSAGIGRTGSVVML
| |.|... . . .| .|| | ..|. |||. ||| ||..| | . ||.|||||||.||||... |
d.....iavrvdrnielpnyvirgfkvfne....rdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiial
EYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILN
. ..|| . . .| . |. . .||.. .|. .||.|... .|.
dialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
|
|||||||||
0046846 | (Phosphotyrosine protein) phosphatases II | 101-320 | 2.4e-38 | 127.0 | In-house | 8-174 (176) | alignment | ||
Range on Protein: 101-320
Range on HMM: 8-174/176.0
GPWPHEYIHANYVATPtnpkRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMdfdeggqkisvkcessvtysfradak
... ||.||..... |.|.||.||..|.|||. | .. .......|.. |.| ||. |.| .. .
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................
anvtateiviegpgektrkttHYHWNDWPDRGVPAAD--MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyimdqLLAGQIIDDGEKILVKICEQR
.|.. .||| ||| . . .||....|. ..||..||||||||||| .|.. || . . |..| .. |||
.....................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqR
N-NSIQTDAQYLFVHQVILNYFR
...||..|| |.....| ...
plgavqtpeQyrflyefellllk
|
|||||||||
subfamily_Sponge-PTP5_pd | Subfamily Sponge-PTP5 | 78-317 | 6.7e-38 | 125.2 | In-house | 31-264 (283) | alignment | ||
Range on Protein: 78-317
Range on HMM: 31-264/283.0
AQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVA---TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGDvM
.. |||.... |..||.|. . ...|| | .. . |..| .|.||..| ||| | ...|. | || .. | .|| |.|.. | .
denkrknrnqeivpadqwrvelk.sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.Gs.e
DFdeGGQKISVKCESSVtYSFRADA-KANVTateivieGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELL-ENA-RPSKGPIVVHCSAGIGRTGSVV
|. | .... | . || .| . ..| .|| .|| . | | . .... . . |||||||||.|||||. .
dy..Geftvtlrketts.nsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi
MLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILN
. ....|. ..| ... . ||| .|| || .||...|.
aasasvkdaltesvvdv.favvkimreqrmmavqtldqyklvhelvle
|
|||||||||
0043147 | (Phosphotyrosine protein) phosphatases II | 105-313 | 1.7e-36 | 120.9 | In-house | 5-155 (172) | alignment | ||
Range on Protein: 105-313
Range on HMM: 5-155/172.0
HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFlekgakkcfeyfpskkgdvmdfdeggqkisvkcessvtysfradakanvt
. ||.|.|. .. |.|||.||.|| |.|||| |... .. .|..|...
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................
ateivIEGPGEKTRKTTHYHWNDWPDRGVPaADMAVLELLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllaG-QiidDGEKILVKICEQR
| .| .|.. ||| ||| .||.|| |. ..||..||||||.|||| .|.. ... . |... . |.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl...sleeavalvrekR
NNSIQTDAQYLFVHQ
....|.. || |...
pgavqnpsqyrflyy
|
|||||||||
subfamily_Choan-PTP-3_pd | Subfamily Choan-PTP-3 | 72-321 | 5e-36 | 119.0 | In-house | 30-279 (287) | alignment | ||
Range on Protein: 72-321
Range on HMM: 30-279/287.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKL--EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
.|| .| .. |||| || .|..|| | || .|| |||||. |. ..||..|.|. | ||| . .. .. . .. .|.. .||..|.| .
fkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer
kGDVMDFdeGGQKISVkcessVTYSFRADAkaNVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA--D--MAVLEL---LENARPS--KGPIVVHCSA
| || . . . |. . . . .|. ....| ... .|||.... . ||. .| || . ||.|||...
.evPmrv..GGysvvl.....ldydikePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv
GIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
||||.| .. . ....|. .| ...... |.|. .|. |. .. . . |..
GiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyykt
|
|||||||||
0036282 | (Phosphotyrosine protein) phosphatases II | 105-313 | 5.1e-36 | 119.3 | In-house | 2-164 (174) | alignment | ||
Range on Protein: 105-313
Range on HMM: 2-164/174.0
HEYIHANYVATPTNPKRFICTQAPLEktcadFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkgdvmdfdeggqkisvkcessvtysfradakanvt
. ||.|... ..|.|..|.||. ||.|... ......||.. |.| ||. |.|.
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................
ateivieGPGEKTRKTTHYHWNDWPDRGVPAADMaVLELLENARPS-----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLagQIIDDGEKILVKICEQRN
. .| .|.. |||.||| .. .||... .. .||..||||||.|||| .|.. ... .|| . .| ... .. ||
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp
NSIQTDAQYLFVHQ
...||. || |...
gmvqtpsQyrflyy
|
|||||||||
subfamily_Sponge-PTP9_pd | Subfamily Sponge-PTP9 | 61-321 | 1.7e-35 | 117.2 | In-house | 22-295 (301) | alignment | ||
Range on Protein: 61-321
Range on HMM: 22-295/301.0
VGMRRFNDFEKMKAFkEAQEAGKNRYKDVGCLDNNRVKLEGPW-----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
... .| . . . . ... ||.|.. .|.||. |. .||| |.|. .. |.|| .|.|..|| .||| . .|.|. | |..|
kelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlk
EKGAKKCFEYFPSKKGDVMDFDEGGQKISVKC--ESSVTYSFR---ADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----E
|. .||..|.|. . . .| . ... .. . | .. |. | . .... . .. |||. || ||. .
egtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihr
NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
. ....||.|||||....|.| . .. ..| | ..| .. . .. ..| || ....|| |..
qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf.qvtkavrrskpgaVtTLeqytsiydvidmylql
|
|||||||||
subfamily_Urchin-PTP-5_pd | Subfamily Urchin-PTP-5 | 80-320 | 3.2e-35 | 116.7 | In-house | 51-285 (297) | alignment | ||
Range on Protein: 80-320
Range on HMM: 51-285/297.0
EAGKNRYKDVGCLDNNRVKLEGPWPH---EYIHANYVatPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNfLEKGAKKCFEYFPSKKgdVMDF
. |.|||.. | .||||. . .|. | .| ..| .|.|.|| | . | |||| | ....| | || . .... ||| |.. | |. |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlnd.dnerdkkcaryWsdkg..vttf
degGqKISVKCESSVtysfraDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
| ..||. .| . . . . | .| ..| |.. .|||. |. ..|.|... | ..||..|||.||.|||| ..
...G.dvsvvllsvs......ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll
MLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. .. . . .| ... |. ..| . .||. || ||....|...
tidsvvaeakrekevdif.glvkklrqerpylvqtkeqykfvyvavleall
|
|||||||||
subfamily_Urchin-PTP-3_pd | Subfamily Urchin-PTP-3 | 70-319 | 4.4e-35 | 116.3 | In-house | 38-288 (325) | alignment | ||
Range on Protein: 70-319
Range on HMM: 38-288/325.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEyIFMLCNFLEKGAKKCFEYF
.|. .. |||.|.| ||..|| || |. .|| |.|. . . . |. .|||| .| |.| . .. . . .. | |..| ..| |.
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrcavyw
PSKKGDVMDFdeGGqkISVKCESSVTYSFRADAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPA---ADMAVLELL----ENAR---PSKGPIVV
| . |. | || . || . ..| . .| .. . .|| ... |.| ||. . ...|.|. | . . .||.|
pkemgksktf..Gg..levklrtieeisdyvhrvldvkqvk......kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv
HCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||||.|||| . | ...... .| . . |. ..| . ..| || .... . ...
hcsaGvGrtGvfislysalakvieesrvdifg.fvkklrkdrpsmvetvdqyiliyealveay
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 81-323 | 5.1e-35 | 117.1 | In-house | 47-284 (314) | alignment | ||
Range on Protein: 81-323
Range on HMM: 47-284/314.0
AGKNRYKDVGCLDnNRVKLeGP---WPHEYIHANYVATPtnpKRFICTQAPLEKTCADF----------WYMC--YQDKVEYIFM---------------
||||.|. . | |||.| . . ||.|.|| .. ..||.||.||| |. || | | .. .| .| |
rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda
------LCNFLEKGAKKCFEYFPSKKgdvmdfdeggqkisvkcessvtysfradakanvtateI-------ViegpgekTRKTTHYHWNDWPDRGVPAAD
|... ..|. ...... | . .| .|.. ..|| ..| .
AlgKtpllildgngneptaadlellk.....................................eelydpelf.......erlgikylripvpDgsaplle
M--AVLELLENArPSKGPIVVHCSAGIGRTGS-VVMLeYIMDQLlagQIidDGEKILVKICEQRN-----NSIQTDAQYLFVHQVILNYFRKKK
. ..||..|.| . .||..|||.||.||||. ||. |.| .| .. . |..| . ..| ..|.. ||.|.....|.|....|
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa.ylmkll...gv..sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
|
|||||||||
subfamily_Cele-PTP-1_pd | Subfamily Cele-PTP-1 | 89-325 | 1.1e-33 | 111.7 | In-house | 27-257 (290) | alignment | ||
Range on Protein: 89-325
Range on HMM: 27-257/290.0
VGCLDNNRVKLEG---PWPHEYIHANYVATPTNpKRFICTQAPLEKT-------CADFWYMCYQDKVEYIFMLCNFLEKGAK----KCFEYFPSKKGDVM
| . ..|| |.| .|||||.| | . |.| ||.|.||. .||.| |.||. . |||.| || |. | .|.| . |. .
vpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel
DFDEggqkISVKCessvtysFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyI
|. ..||| .. .| |.|.. .|. . ||. ..| .. |. .|.|... . || |..||| || | . .. .
kfkg....ltvkC.......kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.l
MDQLLAGQ-IIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILnyfrkkklM
|..|.. |..| .. .||.. |... .. || .|. .
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv........l
|
|||||||||
subfamily_Urchin-PTP-4_pd | Subfamily Urchin-PTP-4 | 74-318 | 2.3e-33 | 110.1 | In-house | 39-235 (392) | alignment | ||
Range on Protein: 74-318
Range on HMM: 39-235/392.0
AFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfeyfpskk
. .. . |||||.. .|..||||| ..|. | |. . | | .|..|.| . ||| | .|..| | |. .. |
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............
gdvmdfdeggqkisvkcessvtysfradakanvtateiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTG
|...| . .|. .|||..|| ..|..... . | |...|||||.||||
..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtg
SVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNY
|. .. .. . ...| .....| ..| .||. || |.. .|.
vvisidsvvahakktrmvdv.fnfvtnirrkrpymvqtkeqyafiygavled
|
|||||||||
subfamily_Anemone-PTP-1_pd | Subfamily Anemone-PTP-1 | 76-316 | 8.2e-33 | 108.5 | In-house | 4-238 (239) | alignment | ||
Range on Protein: 76-316
Range on HMM: 4-238/239.0
KEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
|. . |||| .. | .|| || || .|| |.|. .|| .|.|| .| .. ||| | .|.. | || ..| |||..|.|
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts
DVMDFDEGGQkisvKCESSVTYSFRADAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGS
.. . | | | |. ..| || | .||. |||.||| ||| | ... | | |.|||||.||||.
kycnlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga
VVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVIL
..... .. | . .| . . | |.| .|| ||.|.| .|
flvidamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavl
|
|||||||||
subfamily_PTPRN_pd | Subfamily PTPRN | 41-315 | 8.3e-33 | 108.3 | In-house | 17-288 (297) | alignment | ||
Range on Protein: 41-315
Range on HMM: 17-288/297.0
ILKFVQRTLEKmPQGLRAEFVGMRRFNDFEKMK-AFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVAT--PTNPkRFICTQAPLEKTCA
.|.... |.. .. |..|. .. ... .. | . |. . . |||.|.| |..||||. ..|| | . | .| .| ||.|| .| |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva
DFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGG-QKISVKCESSVTYSFRadaKANVTAteiviegpgEKTRKTTHYHWNDWPDRGV
||| | ... | | .|.. |.| |.| .|.| . .| .. | . |. . || |. . ..|| | .|. ||..||
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfy...lknlqt.........setrtvtqfhflswpeegv
PAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVI
||. ..||. | |||||||.| |||| .... ....|| | | | .. .||.. ..| .|. |. ...
PasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
|
|||||||||
subfamily_Nvec-PTP-1_pd | Subfamily Nvec-PTP-1 | 79-317 | 8.8e-33 | 108.4 | In-house | 6-238 (239) | alignment | ||
Range on Protein: 79-317
Range on HMM: 6-238/239.0
QEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVM
. |||| .. | .|| || || .|| |.|. .|| .|.|| .| .. ||| | .|.. | || ..| |||..|.|
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc
DFDEGGQkisvKCESSVTYSFRADAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGSVVM
.. . | | | |. ..| || | .||. |||.||| ||| | ... | | |.|||||.||||....
nlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv
LEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILN
.. .. | . .| . . | |.| .|| ||.|.| .|.
idamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavle
|
|||||||||
0049260 | (Phosphotyrosine protein) phosphatases II | 117-313 | 7.2e-32 | 105.6 | In-house | 6-144 (152) | alignment | ||
Range on Protein: 117-313
Range on HMM: 6-144/152.0
TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFpskkgdvmdfdeggqkisvkcessvtysfradakanvtateiviegpgek
.|..||.||.|.. |.|||| | .. .. .| ||...||.| || .|.
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................
trkttHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllagqIIDDGEKILVKICEQRNNSIQTDAQYLFVH
.|.. ||| ||| .. .|.||. |. ..||..||||||.|||| .|.. ... . |... . |.|...... |. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
Q
.
e
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 98-322 | 1.2e-29 | 98.6 | In-house | 11-174 (178) | alignment | ||
Range on Protein: 98-322
Range on HMM: 11-174/178.0
KLEGPWPHEYIHANYVAtptnPKRFICTQAPlektcADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdvmdfdeggqkisvkcessvtysfra
.|||.. .||.|... | ..... | ||.. . .. .. .| .|.. || | ||..|.|.. |
nleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................
dakanvtateiviegpgektrktTHYHWNDWPDRGVPA---ADMAVLELLENAR-PSKGPIVVHCSAGIGRTGSVVMLEYIMDQllagQIidDGEKILVK
.|.. .|| ||| ....|..|.|. ...||..||||||.||.|..|.. ... . .. . |...
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl..sleeaiel
ICEQRNnSIQTDAQYLFVHQVILNYFRKK
. |.|. .... |. ..... | .. ..
vrerRp.ivpnpgqlrqLyefelrllkes
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 106-315 | 1.7e-28 | 94.5 | In-house | 4-149 (151) | alignment | ||
Range on Protein: 106-315
Range on HMM: 4-149/151.0
EYIHANYVATPtnpkrFICTQAPLEktcaDFWYMCYQDKVEYIFMLCNFLEKGakKCFEYFPSKKgdvmdfdeggqkisvkcessvtysfradakanvta
||...|| ......||. ||. . .. .. .|..|.. | | .| ||.|.
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................
teiviegpgektRKTTHYHWNDWPDRGVPAADMAVLELLENARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQllagqiiDDGEKILVKICEQRNNSIQT
.. .|... |||| |.| ||||.|| .. .||..||||||.|||| .|.| .. . . |..| . ..| ...|.
............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp
DAQYLFVHQVI
|.||.....
nqqflfqlfal
|
|||||||||
subfamily_CG7180_pd | Subfamily CG7180 | 76-319 | 3.7e-28 | 93.0 | In-house | 38-290 (296) | alignment | ||
Range on Protein: 76-319
Range on HMM: 38-290/296.0
KEAQEAGKNRYKDVGCLDNNRVK---LEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAkKCFEYFPSKKgd
... .|||. .| |.||| |.| .|| | || . . .| .| |.|| ..| .|| . |..... . .|.. . .. .|.| |
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..
VMDFDEggqkISVKCESSVTYSFRADAKANVT----ATEIVIEGPGEKTRKTTHYHWNDWPD-RGVPAADMAVLELLE-------NA--RPSKGPIVVHC
.. | | |. .. .|. . .| |. .. .|| ..... |. || |..||.. .. .| .||.||..
keqyge....ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs
SAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYF
| | .|.| . .. .... . .| | . .. ..|.. ... .| .. .|.|...
sdGasRsGvylaidanlelvekeeevdvFe.avktlrrsRpqLvenveeYkyiYdvlleav
|
|||||||||
PTPc_DSPc_SM00012 | 220-316 | 3.8e-28 | 93.1 | In-house | 2-104 (105) | alignment | |||
Range on Protein: 220-316
Range on HMM: 2-104/105.0
TTHYHWNDWPDRGVPAADMAVLELLENARPSKG------PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQ
.|||...||| ||| ..||||.. . .| |.|||||||.|||| .|.|.....|| ... .| ..|. .. .||....||..||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
VIL
..|
all
|
|||||||||
subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 54-331 | 1.2e-27 | 91.1 | In-house | 26-296 (302) | alignment | ||
Range on Protein: 54-331
Range on HMM: 26-296/302.0
QGLRAEFVGMRRF-NDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNPKRFICTQAPLEKTC---ADFWYMCYQDKVEYIF
. ...|| . . | || ||||. . ||. .|| .||.|.||||. | .|..| | | . | .| | .. ..|| | .|.|. ..
aevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv
MLCNFLEKGAkKCFEYFPSKKGDVMDFdeggQKISVKCESsVTYSfrADAKaNVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMA----VLELLE
.| | |.|| | || .. .|. | | .. ..| . . |.. || . .. |. . |.. || . . .. .
ilvgeeelkk.tlselfpkksgdykey....gkmfvNnrk.Veka..eeek.tryviEvlPegcsnsvl.anvyvltnWkqkkvpvkyaeliktaakvfa
NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHqVILNYFRKKKLMDESGVQ
. ... ..|. |.|| |... | ...| .|. | |. .| .|| ..... || ... ..|... |||. .... .
kkikadentvivSknGaGRagafltlavaveklqkgkepnike.ivksiRsqRpravdslkQyvsly.ialllyikkkvtkpeekk
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 76-235 | 1.8e-27 | 91.0 | In-house | 26-181 (297) | alignment | ||
Range on Protein: 76-235
Range on HMM: 26-181/297.0
KEAQ---EAGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVATPTNPK--RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
|. ||||.|. |..|||| . . ..|| |.||. | ... ..|..| ||..| ||| . ... | | |.... | | .||. |.||
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv
KGDVMDfdeggqKISVKCESSVTYSfraDAKANVTATEIVIEGPgEKTRKTTHYHWNDWPDRGVPA
... . .| | ..| | .| ||. . ...|. .| . ||| |||.
vqerlk......agdvvveflssts...defdrviltelqliyr.sesrvvrhvqflswpdhGvps
|
|||||||||
subfamily_ptpA1_pd | Subfamily ptpA1 | 79-277 | 8e-27 | 89.0 | In-house | 46-255 (418) | alignment | ||
Range on Protein: 79-277
Range on HMM: 46-255/418.0
QEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATpTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmD
... |||| .. .. ||.|. .|| |||. . ||.||||| || .| |||| | ..... | || |. || |.| . | .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.q
FDEGGQKISVKCESSVTY-SFRADAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------RPS---KGPIVVHCSAGIGR
| |. | || | . .. . .| . || || |.|... |||. .| . .|| . || . ||.||||||.||
fsiygngnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr
TGSVVMLEYIMDQ
||... .| .
tgtfctavimmkk
|
|||||||||
subfamily_Cele-PTP-7_pd | Subfamily Cele-PTP-7 | 126-330 | 1.5e-25 | 84.3 | In-house | 97-294 (302) | alignment | ||
Range on Protein: 126-330
Range on HMM: 97-294/302.0
QAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQK-ISVKCEssVtYSFRADAKANVTATEIVIEGPGEKTRKTTH-Y
| .|. .| . | .| . ||.| |.. ||| ||. | |... | . | .||| . . | .... . || | .|..|| .
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd..l.eeftdkksfklytveiknekkkkkvkktvdil
HWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVIlnyfrKKK
.. ||| | |. . |..| | ..||||||.||||..| . | . || . . . | .|.. . . | ..|.. | ... .. |
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv.....tkg
LMDESGV
||. ||
lmekagv
|
|||||||||
subfamily_Cele-PTP-9_pd | Subfamily Cele-PTP-9 | 130-328 | 8.2e-25 | 82.3 | In-house | 38-230 (255) | alignment | ||
Range on Protein: 130-328
Range on HMM: 38-230/255.0
EKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESsvtysfrADAKANVTATEIVIE-GPGEKTRKTTHYHWNDW
| . |. . | | | . |||.| |.| .|| .||| .| . . . . ..| . . |. . . ||. . | ||.. .||... |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGW
PDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
... | .|..| .| || ..|||||.||||. . |. |.. ... . .. | ..| .. ..|. .|.| | | ..|... |.
ieknaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg
LMDES
...
eleak
|
|||||||||
subfamily_Sponge-PTP1_pd | Subfamily Sponge-PTP1 | 59-319 | 9.6e-23 | 75.5 | In-house | 11-259 (267) | alignment | ||
Range on Protein: 59-319
Range on HMM: 11-259/267.0
EFVGMRRFNDFEKM-KAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEK
|| ... | . . . . .||. |. |..|| | .||| | || . . || || ||..| .||. . . || | .| . .
efelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd
gakKCFEYFPSKKGDVMDFDEGGQKISVKCESSvtysfradaKANVTATEIVIEgpGEKTRKTTHYHWNDWPDRGV------PAADMAVLELLENARPsk
. ..| | |. ... . |.. | .. . |. .. | ... | |... | | . . |||. .
...nirlfwPPkmgqakkyqdltvehslekeen.........dyqiitlelkfk..nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnr..
gPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|.||.||.|.||.|. .... .... .. | . | || .|| ..| .|...|... .|
.PlvvacsdGvGrsGtflvidsqleraktegvsd.ifdflrkirsqriglvdtkeryiyihellaeya
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 105-250 | 1.1e-22 | 75.2 | In-house | 56-193 (319) | alignment | ||
Range on Protein: 105-250
Range on HMM: 56-193/319.0
HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgdvmdfdEGGQKISVKCESSVTYSFRADAKANV
||..|.|| . . | .|..|..||.. .||| . .. . | |.. |.| |.| ||.|.| |... |. . || |. . .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk........etldntslyGdilvtlkgrevkdrya
TATEIVIEGPGEKTRKTTHYHWnDWPDRGVPAADMAVLELLENARPS
..| .. . .|..|. ||| . .|.. .||| . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
|
|||||||||
0048076 | (Phosphotyrosine protein) phosphatases II | 195-318 | 1.1e-21 | 72.4 | In-house | 22-142 (145) | alignment | ||
Range on Protein: 195-318
Range on HMM: 22-142/145.0
FRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQllaGQiiDDGEKIL
.. .. ..|. . . .|. ..|.. .|||.||| . ...||..|.|....||..||||||.||||..|.. |.| . . . |..|
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll...lg..vsleeal
VKICEQRNNSIQTDAQYLFVHQVILNY
.. .|| ...... |. |.....| .
elvrsqrpgavpnpgqlrflyefelel
|
|||||||||
subfamily_hpo-7_pd | Subfamily hpo-7 | 125-332 | 3e-21 | 70.5 | In-house | 39-242 (263) | alignment | ||
Range on Protein: 125-332
Range on HMM: 39-242/263.0
TQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESSVTysfradakANVTATEIVIE--GPGEKTRKTTH
... | .| . |. . | | | . |||.| |.| .|| .||| .| . . . . ..| . .. . |. ... | ||.. .|
lysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan....vnvcttkvqs........dvllktlellstlgeKkkthtvkh
YHWNDWPDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKICEQRNNSIQTDAQYLFVHQVILN
| .. |... | .|..|. || || ..|||||.||||. . .. | . ... . .. | ..| .. ..|. .|.| | | ..|.
ysykgWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
YFRKKKLMDESG--VQE
.. . .| ||
fvlnnfakgeleakyqe
|
|||||||||
subfamily_Cele-PTP-16_pd | Subfamily Cele-PTP-16 | 79-318 | 1.3e-19 | 64.9 | In-house | 46-278 (303) | alignment | ||
Range on Protein: 79-318
Range on HMM: 46-278/303.0
QEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPTNpKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPsKKGDVMDFDE
.. |||. || ||| .||| ||||.|. .. |. | || || .|.|||| | ..|| ...| | || .. | ..|.|
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfee
ggQKISVKCESSVTYsfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--------MAVLELLENARPSKgPIVVHCSAGIGRTGSVVM
. | | | .. . .. |. .|...|| .|. . .| . .|. | | .| ||.|. .
..rsirvgefkrvel.......gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal
LEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNY
.| | . | | | | .. . | ..| .|. .|. .. ..
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
|
|||||||||
0048179 | (Phosphotyrosine protein) phosphatases II | 216-313 | 2.8e-19 | 64.7 | In-house | 45-139 (144) | alignment | ||
Range on Protein: 216-313
Range on HMM: 45-139/144.0
KTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllAGQiiDDGEKILVKICEQRNNSIQTDAQYLFVH
.| ..|.. .|||.||| . ..||..|.|....||..||||||.||||..|.. .. . . |..| . ..| ...... |. |..
leregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgqlrfLl
Q
.
e
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 77-169 | 4e-18 | 60.3 | In-house | 44-153 (350) | alignment | ||
Range on Protein: 77-169
Range on HMM: 44-153/350.0
EAQEAGKNRYKDVGCLDNNRVKLE-----------GPWPHEYIHANYVATP-----TNPK-RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGA
. |||||.. . .||||. . .|| |||. . ||. ..| ||||| .| ||. .....||. | .| . | .
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl
KKCFEYFPSK
.|| .|..
ekcyrYWqeg
|
|||||||||
subfamily_Urchin-PTP-2_pd | Subfamily Urchin-PTP-2 | 216-318 | 1.9e-15 | 51.2 | In-house | 87-193 (440) | alignment | ||
Range on Protein: 216-318
Range on HMM: 87-193/440.0
KTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLF
..| .||.. |||.||| ||..... ..||..|||||| |||| .. .. |. . . || .. . ..| . .|| || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyaf
VHQVILNY
||...|.
vheavleg
|
|||||||||
subfamily_Choan-PTP-4_pd | Subfamily Choan-PTP-4 | 241-317 | 1.1e-14 | 49.0 | In-house | 218-293 (297) | alignment | ||
Range on Protein: 241-317
Range on HMM: 218-293/297.0
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |. . | . ...||||||.||.| ||. . |...| . | | || .. ||| .|| |. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlk
|
|||||||||
subfamily_CG42327_pd | Subfamily CG42327 | 248-320 | 1.2e-12 | 42.1 | In-house | 244-316 (319) | alignment | ||
Range on Protein: 248-320
Range on HMM: 244-316/319.0
RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
| |.||.||||| |.|||| |. . . .| . | ... . ..| ....| || |...|. .| .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
|
|||||||||
subfamily_Nvec-PTP-3_pd | Subfamily Nvec-PTP-3 | 120-272 | 1.9e-11 | 38.5 | In-house | 4-155 (198) | alignment | ||
Range on Protein: 120-272
Range on HMM: 4-155/198.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL-EKGAKKCFeYFPSKKGDVMDFdeGGqkISVKCESSVTysfRADAK-ANVTATEIVIEgPgEKT
.|.|.|| || .| |||| | .. .| |. . .| | | |.|. . . . | .|| ... .| ..| . . |. . | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..gs..lsvttktitt...kpdytitaliltnntta.p.pst
RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLE
|. .|| . | .. | . | .. | |..|||| | | || | |.
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald
|
|||||||||
subfamily_Anemone-PTP-3_pd | Subfamily Anemone-PTP-3 | 120-272 | 2e-11 | 38.4 | In-house | 5-156 (199) | alignment | ||
Range on Protein: 120-272
Range on HMM: 5-156/199.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL-EKGAKKCFeYFPSKKGDVMDFdeGGqkISVKCESSVTysfRADAK-ANVTATEIVIEgPgEKT
.|.|.|| || .| |||| | .. .| |. . .| | | |.|. . . . | .|| ... .| ..| . . |. . | |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..gs..lsvttktitt...kpdytitaliltnntta.p.pst
RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLE
|. .|| . | .. | . | .. | |..|||| | | || | |.
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 101-167 | 4.9e-11 | 36.5 | In-house | 86-154 (349) | alignment | ||
Range on Protein: 101-167
Range on HMM: 86-154/349.0
GPWPHEYIHANYVATPT--NPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFP
. ...|| |||. . |..|.||||| | ||. . ..|. .. | . |.. .|| |.
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
|
|||||||||
subfamily_Fungi-PTP1_pd | Subfamily Fungi-PTP1 | 251-322 | 6.5e-11 | 36.5 | In-house | 262-347 (350) | alignment | ||
Range on Protein: 251-322
Range on HMM: 262-347/350.0
KGPIVVHCSAGIGRTGSVVMLEYIMDQL--------------LAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
||.||||||.|||| .| |.... .. | .. | . |. .. .|| . .|. |..|... .|.||. .
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLr
|
|||||||||
subfamily_eak_pd | Subfamily eak | 83-236 | 3.1e-10 | 33.9 | In-house | 55-197 (332) | alignment | ||
Range on Protein: 83-236
Range on HMM: 55-197/332.0
KNRYKDVgCLDNNRVKLEGP--WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFdeGg
.| .| | | . |.| . || | . . ...| | .. |. || | .. | | .| . .|.. .| ||| | ....| |
rnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf..G.
qKISVKCESSVtysfradaKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA
.. |.. . | | |. | .. |..| . ||. | . .|
.ildverkefv........krniletrllelskGnethrvlhykvfGwtettlpky
|
|||||||||
subfamily_Cele-PTP-5_pd | Subfamily Cele-PTP-5 | 130-341 | 1.4e-09 | 31.0 | In-house | 128-331 (346) | alignment | ||
Range on Protein: 130-341
Range on HMM: 128-331/346.0
EKTCADFWYMCYQDKVEYIFMLCNfLEKGAKKCFEYFPSkkgdvmdfDEGGQKISVKCessVTYSFRADAKAN--VTATEIVIEGPGEKTRKTTHYH--W
| ||||| ||.... .... .| . | ..|| . . | . ||| . . |.. || . |.| |
esfvedfwymiyqeqihlvylmvp.ddklkntttslfnd........enggyqytgkm...finnrradvsgdpkeytievlpegnsdsvicqvhhhapw
N--DWPDRGVPAADMAVLELLENARPSKGPIVVhCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
. . | . .| | | |. . | || | ||. | . | ..|| | | . .|. .| .|| .... ||| .. ....| .|.
khlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnng.iepniceimknikqqrpggvesfaqyasiyaivfdyiarkr
LMDESGVQEAYDAFLEQY
.. |. . |...
ggkkapvnkdinrfidel
|
|||||||||
subfamily_PTPDC1_pd | Subfamily PTPDC1 | 223-318 | 7.6e-09 | 30.3 | In-house | 85-175 (182) | alignment | ||
Range on Protein: 223-318
Range on HMM: 85-175/182.0
YHWNDWPDRGVPAADM--AVLELLENARpSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLagqiidDGEKILVKICEQRNNSIQTDAQYLFVHQVILNY
.. |.| ||.. . . ... | ..| . ||| || |||| .. . . | ..|| . .. ..| .|||| | .|.. |
vynfgwkDygvasleriLdivkvvafal.qegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksiqtreqvelvkefalfl
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 190-322 | 1.4e-08 | 28.6 | In-house | 200-341 (347) | alignment | ||
Range on Protein: 190-322
Range on HMM: 200-341/347.0
SVTYSFRADAKANVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMAVLELL----ENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL
.|. |. . | . |.| || | | . | || . | || |. .. .| . |.|| | |. |. .||. |..|.
avevdqrnknwmnkytvevvaegcseatf.akvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqv
LAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|.|. | .... |. .|| . | . . | |.. |
ldgkt.pdcddlfkkmrdqragvftmsifytyairaalfylklk
|
|||||||||
subfamily_Sponge-PTP4_pd | Subfamily Sponge-PTP4 | 71-233 | 1.9e-08 | 28.2 | In-house | 87-235 (244) | alignment | ||
Range on Protein: 71-233
Range on HMM: 87-235/244.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfEYFPSK
|| . ... ||| .| ||| | .| || | .| .| || || | ||| | . .|. . .| |. ||.|
vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds
kgDVMDFDEGgqKIsvkcesSVTYSFRADAKaNVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGV
. ... | | .|| . | . | |. |... || | . | . .|| |
..eplewyee..di......tvtltdrdefk.nikasnleiesdmneshqaltmfqisnwpsdgt
|
|||||||||
DSPc | Dual specificity phosphatase, catalytic domain | 239-277 | 3.2e-08 | 28.5 | Pfam-A | 61-98 (133) | alignment | ||
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |...... |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
|
|||||||||
DSPc | Dual specificity phosphatase, catalytic domain | 239-277 | 3.2e-08 | 28.5 | In-house | 61-98 (133) | alignment | ||
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |...... |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
|
|||||||||
PTPc_motif_SM00404 | 239-276 | 3.4e-08 | 28.5 | In-house | 68-104 (140) | alignment | |||
Range on Protein: 239-276
Range on HMM: 68-104/140.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMD
.||. .|||. ..| ..||| ||. |...... |.|.
kvldfienaekkggkvlVHCqaGvSRSatliia.Ylmr
|
|||||||||
0038934 | (Phosphotyrosine protein) phosphatases II | 220-270 | 5e-08 | 28.3 | In-house | 67-134 (194) | alignment | ||
Range on Protein: 220-270
Range on HMM: 67-134/194.0
TTHYHWNDWPDRGVPAADMAVLE------------LLEN-----ARPSKGPIVVHCSAGIGRTGSVVM
.. |. ......|. .. . . |. .. ..| ..||| ||.|||| .|
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
|
|||||||||
subfamily_DSP19_pd | Subfamily DSP19 | 229-278 | 5.7e-08 | 27.2 | In-house | 67-115 (152) | alignment | ||
Range on Protein: 229-278
Range on HMM: 67-115/152.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQL
|. . . ..|. .|.|| ..| ..|||.||. |. |||. |.| .
petdllsylkealdFieearskdgavlvHCnAGvSRsasvvi.aylmkke
|
|||||||||
PTEN_1 | 217-269 | 7.1e-08 | 27.5 | In-house | 91-148 (196) | alignment | |||
Range on Protein: 217-269
Range on HMM: 91-148/196.0
TRKTTHYHWNDWPDRGVPAADMAV--LELLENARP---SKGPIVVHCSAGIGRTGSVV
.. |. ...| |.| .. .. ..... ... ..||| ||.||.| ||
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
|
|||||||||
subfamily_eak_pd | Subfamily eak | 247-323 | 1.5e-07 | 25.1 | In-house | 233-309 (332) | alignment | ||
Range on Protein: 247-323
Range on HMM: 233-309/332.0
ARPSKGPIVvHCSAGIGRTGSVVMLEYIMdQLLAGQIIDD--GEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
. || ||. .. | |.| |... .. .|. ... . |....|. ..|. |. .. |. |.....|.|.....
tppsfapii.qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
|
|||||||||
subfamily_Cele-PTP-17_pd | Subfamily Cele-PTP-17 | 80-154 | 2.7e-07 | 24.4 | In-house | 37-119 (347) | alignment | ||
Range on Protein: 80-154
Range on HMM: 37-119/347.0
EAGKNRYKDVGCLDNNRVKLEgP---------WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
. ||| ||| |. || | | .. || | .. | .| || || .| ||| | . || . . .
slsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
|
|||||||||
subfamily_Fungi-PTP2_pd | Subfamily Fungi-PTP2 | 251-321 | 3.1e-07 | 24.0 | In-house | 265-346 (349) | alignment | ||
Range on Protein: 251-321
Range on HMM: 265-346/349.0
KGPIVVHCSAGIGRTGSVVMLEYIMDqlL------------AGQIIDDGEKILV-KICEQRNNSIQTDAQYLFVHQVILNYFRK
...|||||| |||| .| |..... . .. | | | .. || . .| ||. .... .|.||.
lstllvhcsaGcGrtGvlvtldllls..ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfal
|
|||||||||
subfamily_Cele-PTP-2_pd | Subfamily Cele-PTP-2 | 93-213 | 3.2e-07 | 22.2 | In-house | 58-178 (327) | alignment | ||
Range on Protein: 93-213
Range on HMM: 58-178/327.0
DNNRVkLEGPwPHEYIHANYVATptNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLE---KGAKKCFEYFPSKKGDVMDFDEGGQKISVKCES
|| || | | |.. .|| . .| ||| .|. | . .|.. . || . ||. |||.. . |. . .|. |..
dnrrv.lcgs.deeffpgqyvrm..egaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsivcka
SVTYSFRAD-AKANVTATEIVIEGP
|. | . ..| .|.||.
reglsmgatkyeleltdsevvidkn
|
|||||||||
subfamily_CDC14_pd | Subfamily CDC14 | 236-277 | 4.3e-07 | 24.1 | In-house | 248-288 (328) | alignment | ||
Range on Protein: 236-277
Range on HMM: 248-288/328.0
ADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
|. | ..|| | ..| |.||| ||.||||... |.| .
sdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkh
|
|||||||||
subfamily_DSP1_pd | Subfamily DSP1 | 227-277 | 6.9e-07 | 23.5 | In-house | 71-120 (163) | alignment | ||
Range on Protein: 227-277
Range on HMM: 71-120/163.0
DWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
| |. . . . |.| ..... ..| . .|| ||| | ..... |.| .
DspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla.ylmkt
|
|||||||||
subfamily_Sponge-PTP-4_pd | Subfamily Sponge-PTP-4 | 95-169 | 1.2e-06 | 22.9 | In-house | 8-72 (130) | alignment | ||
Range on Protein: 95-169
Range on HMM: 8-72/130.0
NRVKlegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfEYFPSK
.|.. ..||.|..| . . .. ||.|| .|. ||| | . |. . .| |. ||.|
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds
|
|||||||||
subfamily_DSP8_pd | Subfamily DSP8 | 240-280 | 2.3e-06 | 21.3 | In-house | 82-121 (159) | alignment | ||
Range on Protein: 240-280
Range on HMM: 82-121/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQLLA
.| .. |. ..| ..||. ||| | .|. . ||| .|
svefidkaksengrvlvhvlaGisrsatva.iayimktlem
|
|||||||||
subfamily_DSP6_pd | Subfamily DSP6 | 241-278 | 4.8e-06 | 20.2 | In-house | 83-119 (158) | alignment | ||
Range on Protein: 241-278
Range on HMM: 83-119/158.0
LELLENARPSKGPIVVHCSAGIGRTGSVvMLEYIMDQL
.|....|| .| ..||| ||| |. | .| |.| .|
iefidearskkskvlvhClaGisrsvtv.tlaylmkkl
|
|||||||||
Y_phosphatase3 | Tyrosine phosphatase family | 218-271 | 6.3e-06 | 21.3 | Pfam-A | 95-144 (164) | alignment | ||
Range on Protein: 218-271
Range on HMM: 95-144/164.0
RKTTHYHWNDWPDRGvPAADMAVLELLENarpSKGPIVVHCSAGIGRTGSVVML
... . . .. ... .| .|||.| . ..||...||.|| ||| |..|
eeamaeayreilede.kkayrkvlealae...eegpvlfHCtaGKDRTGvvaal
|
|||||||||
subfamily_DSP10_pd | Subfamily DSP10 | 240-277 | 8.1e-06 | 19.8 | In-house | 81-117 (159) | alignment | ||
Range on Protein: 240-277
Range on HMM: 81-117/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQ
|| .|.|| . ..||| ||| | .|| . |.| .
alefieearkkgsrvLvhCqaGisrsatvv.iaYlmkh
|