Gene F10G8.1 in Caenorhabditis elegans

Synonym: CELE_F10G8.1, F10G8.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP057_AA protein Get Run
CeleP057_AA_38-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 33-338 1.7e-199 655.9 In-house 1-305 (305) alignment 
Range on Protein: 33-338
Range on HMM: 1-305/305.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
|.|||||||||||.|||||.|.|||||||.|.|||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
ekkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplekt

CADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG
||||||||.|||||.||||||.||||||||.|||.||..||..|.|.|||||||.|||||..||.||||.||.|..||||||||.||.|||||.||||||
cadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrg

VPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESgVQE
|||||.|.|||||.||||||||||||||||||||||||||||.|||||||||.|..|||.||.|||||||||||||||||||||||||||||.||. |.|
vpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee.vke

AYDAFL
||.|||
aykafl
0050432 (Phosphotyrosine protein) phosphatases II 32-323 8.1e-80 263.7 In-house 22-303 (308) alignment 
Range on Protein: 32-323
Range on HMM: 22-303/308.0
VERKQQKKQILKFVQRtlEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLegPWPHEYIHANYVATP--TNPKRFICTQAPL
.  |.  ...||....   . ...|..||  .... . .......  .   ||||||. ..|..||||  . .. ||.|.|| ..   .|..||.||.||
sslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPl

EKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG-DVMDFDeggqKISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWND
..|..||| |... .|..| ||... |.| .||..|.|.. | ... ..    |..|.. |  .       ....| ... ..   ....|. ||.|. .
pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleyg....kftvtllseev.......lddytvrtleltnlgdgesrtvthfhytn

WPDRGVPAADMAVLELLENARPS--KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
||| |||    ..|..|| .| |  .||||||||||.|||| ...|.....|| ... .|  .... |. |||....||  ||||.....| |...|.
WpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvd.vfeavkklReqRpgmvqtpeqylflyralleylklkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 43-322 1.4e-79 262.3 In-house 5-280 (307) alignment 
Range on Protein: 43-322
Range on HMM: 5-280/307.0
KFVQRTLEKMPQGLRAEFVGMRRFNDF-EKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGP-WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
 .|||||.|  | |. ||  . . .     ..||.  ..  ||||.|| | |..|. .. .    .||||||. . ..||.|||.| |||.|  .|| |.
pwvqrtldkgvqalvdefrvlakktpegvtveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwama

YQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQKISVKCESSVTYSFrADAKANVTATEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAV
 |.||| . |||. .| .  || .|.| ..|. . | | .. |||.   . . .   .   |||. ...    ..|.|  .|. |..|||||||  ... 
iqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklap.dedlinvttlkvdw...aqksrtiqhlqwenwpdrgvpqinlta

LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
..|||  |  . |.|||||||.||.|..| . ...|...||.   | .|.. .. .||. .|||.||||..|.|.|.|| ..
inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflel
0040438 (Phosphotyrosine protein) phosphatases II 39-325 3.7e-79 261.6 In-house 3-281 (317) alignment 
Range on Protein: 39-325
Range on HMM: 3-281/317.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCAD
...|..... | .. ..|. ||  .....    .. ..  .  .||||.|. ..|..||||  . .   . ||.|.|| .|  ...||.||.||..|..|
ldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntved

FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|..| ||... |.| .||..|.|.  |... ...    ..|.. | ..       .|..| ... .|.  ....|. ||.|. .||| |||
FwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygd....ftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvp

AADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFrKKKLM
     .|..|| .| .    .||..||||||.||||..........||  .. . | |... .. |||....|| .|| |.....|.|. |.||.
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv.dveeavkelreqRpgavqtpeqyrflydalleyl.krklt
0036941 (Phosphotyrosine protein) phosphatases II 53-324 3.1e-77 255.1 In-house 12-282 (297) alignment 
Range on Protein: 53-324
Range on HMM: 12-282/297.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|. ||  . ..    ......  .   ||||||. ..|..|||| .. .. ||.|.|| ..  ...||.||.||..|..||| |... .|. | ||.
lalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NFLEKGAKKCFEYFPSKKGDVMDFdeggQKISVKCESSVTYsfradAKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP--
.. |.| .||..|.|...|... .     ...|.. |  ..      ....| ... ..   ....|. ||.|. .||| |||     .|...| .|   
elvelgrekcaqywpleegeslty....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA--GQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKL
    |.||..||||||.||.|..........||     .   |  ... |. |||....||  ||.|.....|....||..
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0051299 (Phosphotyrosine protein) phosphatases II 37-319 5.4e-77 254.4 In-house 6-286 (288) alignment 
Range on Protein: 37-319
Range on HMM: 6-286/288.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTC
. ...||.|...| . . ||..||  .....   ...|..  .   ||||.|. ..|..||||  .    .. ||.|.|. .. ....||.||.||..|.
sveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

ADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-----PGEKTRKTTHYHWNDW
.||| |... .|..| ||... |.| .||. |.|.  |... ...    |.|.. | ..       ....| ... ..      .....|. ||.|. .|
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnw

PDRGVPAADMAVLELLENARPS----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|| |||    ..|..|. .| .    .||.|||||||.|||| ...|.....||.... .|  .... ...|||....||  ||.||....| |.
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvd.vleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 37-322 4.3e-76 250.5 In-house 7-292 (305) alignment 
Range on Protein: 37-322
Range on HMM: 7-292/305.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMK-AFKEAQE----AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNP-KRFICTQAPLE
 .  . .||.|.|.   . || || |. ..   .  . ||.  |       ||||.|| | |.. |||. | | .|||||||  |  | |||||.| ||.
thpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld

KTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGgqkISVKcESSVTYSFRADAKANVTATEIVIEgpGEKTRKTTHYHWNDWPD
.|  .||.|  |.||| | |||. .| |  || .|.|  .|. ...  |   | |. . | .  .  ||. ..|  ..     |...    | .|..|||
qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksg...ivve.nvsgskpmerdaeiqitllnltys..gdqkmsvrhlqwtewpd

RGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|||| . .. ||||   | || ||||||||||||||..| .|||....   .      ...  . .||  |||.| ||||.|.|.|||| .|
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
0046845 (Phosphotyrosine protein) phosphatases II 55-323 6e-76 250.8 In-house 1-278 (284) alignment 
Range on Protein: 55-323
Range on HMM: 1-278/284.0
GLRAEFVGMRRFNDFE--KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATP-----TNPKRFICTQAPLEKTCADFWYMCYQD
||..||  ..... .   ......  .   ||||||. ..|..||||  . .    ..||.|.|| ..      ..|.||.||.||..|..||| |... 
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVEYIFMLCNFLEKGAKKCFEYFPSKkGDVMDFdeggQKISVKCESSVTysfraDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLEL
.|..| ||... |.| .||. |.|.. |.|. .     ...|.. |  .     .    |.  |.. .|.....|. ||.|. .|||.|||.    .||.
nvrvIVmltelvengrekcaqYwple.gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedllef

LENARPS------KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQI--IDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
|. .| .      .||||||||||.|||| ...|.....|| ....    | .... ...|||....|| .||.||....|.|...|.
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
DSPc_SM00195 59-319 2.7e-75 248.4 In-house 5-262 (263) alignment 
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
||  ... .  ....  .. ..  |||||.. . |..||||. .    ...||.|||. .....|..|.||.||..|..||| |... ||..| ||... 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYSfradakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|.    |||||. .  ...      .... ... ..  | |.|||.|.|....|||.|||   . |||||. .. |    
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ...  .| ..|. .. .|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 59-319 2.7e-75 248.4 In-house 5-262 (263) alignment 
Range on Protein: 59-319
Range on HMM: 5-262/263.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGP---WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
||  ... .  ....  .. ..  |||||.. . |..||||. .    ...||.|||. .....|..|.||.||..|..||| |... ||..| ||... 
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

EKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYSfradakANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----
|.| .|| .|.|...|. ..|.    |||||. .  ...      .... ... ..  | |.|||.|.|....|||.|||   . |||||. .. |    
engkekcdrywpeesggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts

KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
.||||||||||.||||..|....|...| ...  .| ..|. .. .|| ...||..||||....||.|.
sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0047943 (Phosphotyrosine protein) phosphatases II 53-319 3.7e-74 244.9 In-house 11-272 (273) alignment 
Range on Protein: 53-319
Range on HMM: 11-272/273.0
PQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLeGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLC
...|..||  .... .  ......  .   ||||||. ..|..|||| |. .. ||.|.|| ..  ...||.||.||..|..||| |... .|..| ||.
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

NFLEKGAKKCFEYFPSKKGD-VMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-
.. |.| .||. |.|.. |. .. ...    ..|.. |  |       |...| ... ..    ...|. ||.|. .||| |||.    .||..| .|  
elvelgrekcaqYwpleggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrka

-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
     |.||.|||||||.||||....|....||| ... .|  .... ....|| ...||  ||.|.....|.|.
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.vleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 37-321 5.6e-74 244.9 In-house 10-306 (307) alignment 
Range on Protein: 37-321
Range on HMM: 10-306/307.0
QKKQILKFVQRTLEKMPQGLRAEFVGMRRFND--FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYV--------ATPTNPKRF
. ...|..|...| . ..||..||  ......    ......  .   ||||||. ..|..||||  . .    . ||.|.||         .. ....|
dalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkf

ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG--PGEKTRKT
|.||.||..|..||| |... .|..| ||... |.| .||..|.|.. |... ...    . |.. |  .       ....| . . ..   . ...|. 
IatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrtv

THYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKICEQRNNSIQTDAQYLFVH
||.|. .||| |||     .|...| .|       ..||..||||||.||||..... ....|| .....   | .... .. ||| ...|.  || |..
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

QVILNYFRK
...| ...|
eallelllk
Y_phosphatase Protein-tyrosine phosphatase 82-317 7.2e-71 233.7 Pfam-A 3-235 (235) alignment 
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEgg
 ||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..  ||| .|| .|.|..... . ...  
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..

qkISVKCEssvTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
  |.|...   . . ..... ... .|.  ..  ...|.....|...|||.|||.   ..|.|... . ||    ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |..   |  .|. .. .||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 82-317 7.2e-71 233.7 In-house 3-235 (235) alignment 
Range on Protein: 82-317
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEgg
 ||||||. . |..|||| . . |..||.|||| . ...|.||.||.||..|..||| |..| ||..|.||..  ||| .|| .|.|..... . ...  
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd..

qkISVKCEssvTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK----GPIVVHCSAGIGRTGSVVMLEYIMD
  |.|...   . . ..... ... .|.  ..  ...|.....|...|||.|||.   ..|.|... . ||    ||.|||||||.||||..|.|.....
..ikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

QLLAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |..   |  .|. .. .||....|. .|| |....||.
qleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0043336 (Phosphotyrosine protein) phosphatases II 39-319 1.3e-70 233.4 In-house 5-277 (278) alignment 
Range on Protein: 39-319
Range on HMM: 5-277/278.0
KQILKFVQRTLEKMPQGLRAEFVGMRRFNDfEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCAD
|..||.... | .....|..||  ...|.  . .. ..  .   ||||||. ..|..||||.      .. ||.|.|| ..  |..||.||.||..|..|
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPskkGDVMDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVP
|| |... .|. | ||... |.| .||..|.|   |... ...    ..|.. .  .       ....| . . ..     ..|. ||||. .||| |||
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvp

AADMAVLELLENARP----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
     .|..|. .|     |.||..||||||.|||| ...|.....||  .. .|  |... .. ||| ...||. || |.....| |.
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvd.leeavkelreqRpgavqtpsqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 54-322 2.9e-69 229.1 In-house 32-292 (297) alignment 
Range on Protein: 54-322
Range on HMM: 32-292/297.0
QGLRAEFVGMRRFNDfEkMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYI
..|..||  . .... . .. ..  .   ||||||. ..|..|||| ..      . ||.|.|| ..   ...||.||.||..|..||| |... .|..|
tllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvi

FMLCNFLEKGAkKCFEYFPSKKGdvmdfD--EggqkISVKCESSVTysfradaKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
 ||... |.|  ||..|.|.. |        .    ..|.. .  .       ....| ... ..  ....|. ||... .||| |||     .||.|| 
vmLtklvelgr.kcaqywpeegg.....tygd....ftvtllkveh.......ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflel

ARP------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
.|       ..||..||||||.||||..... ....||  .. .|  .... .. |||....||. || |.....| ....|
vrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvd.vleavkelreqRpgavqtpsqyrflydallellkrk
0040439 (Phosphotyrosine protein) phosphatases II 80-321 8.3e-66 217.4 In-house 11-248 (249) alignment 
Range on Protein: 80-321
Range on HMM: 11-248/249.0
EAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDF
   ||||.|. ..|..||||   .| ... ||.|.|. ..  ..|||.||.||..|..||| |... ....| ||... |.| .||..|.|.  |... .
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley

deggQKISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP------SKGPIVVHCSAGIGRTGSVV
     ...|.. |  .       |...| ... ..     ..|. .|... |||| |||     .|...| .|       ..||..||||||.|||| ..
....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

MLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.. ....||   . .|  | .. .. .||....|.. || |.....| ...|
aaylmleqlekelgvd.leeavkllrsqRpgavqnpeqyrflyeallelllk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 35-325 4.2e-65 214.2 In-house 8-289 (290) alignment 
Range on Protein: 35-325
Range on HMM: 8-289/290.0
KQQKKQILKFVQRTLEKMPQGLRAEFVG-MRRF--NDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATpTNPkRFICTQAPLEK
  | . . ||   . .| ...|  |..  .. .   .. . | | .  |  ||||||| | |  || |.   . .|.|||||   ...  || || .|..
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG.lka.mfiltqGalkd

TCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESSVTysfrADAKANVTaTEIVIEGPGEKTRKTTHYHWNDWPDR
|  |.| |  |.|| .| |||. .|.|  || .|.| |.|.|. | |    |.| |  . .     ||.     |  | .    |  |  |..   |||.
tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGe....itvlcseedd....kdaniikk.tlsvrdkdsGkehklkhlkikswpdk

GVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLM
 |. ...|.| .|   |   ||.||||||||||||. | .|  .. || |. .|  . .   . . | ||.| | ||| . ...|.. .. | .
svalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlld.lvralrnsrlnsvqvdiqylalveilldlGkdfkyi
0045098 (Phosphotyrosine protein) phosphatases II 78-322 3.6e-63 208.9 In-house 31-275 (278) alignment 
Range on Protein: 78-322
Range on HMM: 31-275/278.0
AQEAGKNRYKDVGCLDNNRVKlegpwphEYIHANYVATPtnPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMDFD
   . ||||||. ..|..|||       .||.|.|. ..  ||.||.||.||..|.|||| |... ....| ||....|.| .||..|.|.  |... ..
lgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltyg

EggqkISVKCESSVTYsfRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--MAVLELLENARP-----------------SKGPIVVHC
.    ..|...|  ..      .   . | . .| .. ..|. ||.|.  ||| |||  .  . .|||||  |                  |.||..|||
d....ftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

SAGIGRTGSVVMLEYIMDQLlaGQIIDdGEKILVKICEQRNN-SIQTDAQYLFVHQVILNYFRKK
|||.|||| .|.. .....|  .. .|  .... .. .||.. ..|.  || |.....| .....
saGvgRtGtlvaaylmlell..eggvd.lleavkelrsqRpglavqnleqyrflyefllelllrg
0042113 (Phosphotyrosine protein) phosphatases II 79-320 6.2e-63 207.8 In-house 8-244 (245) alignment 
Range on Protein: 79-320
Range on HMM: 8-244/245.0
QEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkGDVMD
    ||||.|. ..|..||||  . .   . ||.|.|| ..  ...||.||.||..|..||| |... ....|.||... |.| .||..|.|.  |... 
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt

FDEggqkISVKCESSVTysfradaKANVTATEIVIEG-PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
...    ..|.. |  .       ....| ... ..  .  ..|. .|||. .||| |||  .  .|..|| .|      |.||..||||||.|||| ..
ygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

MLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. ....|| . . ..  |... .. .|| ...||. || |.....|....
aaylmleqlekelgvs.leeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPRD_pd Subfamily PTPRD 41-321 8.4e-60 198.0 In-house 10-283 (564) alignment 
Range on Protein: 41-321
Range on HMM: 10-283/564.0
ILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAqEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFW
. ..|..   .  . .  |.  ... . |.. .| |.|    ||||...   |..||.|   ||    .|| |... . ...| .| ||.||..|..|||
lkehvaklkansdlkfeeeykkieegqqftweaankpa.NkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFW

YMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGdVMDFdeggQKISVKCESSVTYSFRADAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPAAD
 |... ... | || .  ||| .|| .|.|.| |    .    ... |. |......     . ... ..       ...|. ...|. .|||.|||   
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tety....geltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgvpesa

MAVLELLENAR----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
 ..|.|... |    | .||||||||||.||||  . ........ . . .|   ... .. .|||  .||  || |.|..||..  .
tslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDi.yqyvkalrkqRnamVqteeQYiFiheailealac
0037934 (Phosphotyrosine protein) phosphatases II 75-319 3e-59 195.8 In-house 5-242 (243) alignment 
Range on Protein: 75-319
Range on HMM: 5-242/243.0
FKEAQEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPtnpKRFICTQAPLEKTCAD----FWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPskk
..  .   ||||.|. ..|..||||||   . ||.||..  .   .|.|.||.||..|..|    || |... ....| ||... |.|..||..|.|   
allpenlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

GDVmDFDEggqkISVKCESSVTysfradaKANVTATEIVIEG--PGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR------------PSKGPIVV
|.|  ...    ..|.. |. .       ....| .....|   ... ||  .|||.  ||| |||     .|..|. .|            .|.||..|
gev.tygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlV

HCSAGIGRTGSVVMLEYIMDQLlaGqiiDDGEKILVKICEQRNN-SIQTDAQYLFVHQVILNYF
|||||.|||| .... .....|  |    | |... .. |||.. ..||  || |.....| ..
HCsaGvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 36-323 7.2e-59 194.2 In-house 7-289 (293) alignment 
Range on Protein: 36-323
Range on HMM: 7-289/293.0
QQKKQILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKT
 ..... ..|... ..   ..  |.  .. ..  ...|| ..|... ||||...   |..||||   ..    .|| |||.   . |. || || || .|
iklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet

CADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgdvmdfdeggQKISVKCESSVTYSFrADAKANVTATEIVIEGpGEKTRKTTHYHWNDWPDRG
  ||| |....|.. | || . .||| .|| ||.|..           ..  .  . .||     . . . .  |. ||  ....||...||.  ||| |
vddfWrmvwekkssiivmltqlvekgkvkCeeYWPad...........eepvlyGdikvtlva.eeeledwvirelkiek.ekeerkvrqyhftsWpdhg

VPAADMAVLELLENAR------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
|| .  ..|..... |       ||.|||||||||.||||  . |. .....   ...|    |.... |.||. .|| .||.|.||..|...|||.
vPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi.fgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_PTPN9_pd Subfamily PTPN9 40-324 1.3e-55 183.6 In-house 2-295 (297) alignment 
Range on Protein: 40-324
Range on HMM: 2-295/297.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
.| ..|.   ||  .||. |.. .|. .   ...|.|   .  ||||.|| |.|. ||.|.   .    .||.||.|    ..| || || ||.||. ||
eieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDeggqKISVKCESSVTYsfrADAKanvtATEIVIE-GPGEKTRKTTHYHWNDWPDRGVPA
| | ....|  | |   ..|.|  || .|.|........|     ..||.  . ...    | |     . ..|.    |..|| ||.    ||| ||| 
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg....dlsvsnveveee...edyk....vrvleiknvkteesrkvthfqflsWPdyGvPs

ADMAVLELLENAR-----------------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
. ...|..||..|                 ||. ||||||||||||||  . |.. ...|   . .|   . . .. .||  ||||. || | .. .|.|
saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvv.etvkllrtqrafsiqtpeqyefcylavley

FRKKKL
  ..| 
alelka
subfamily_PTPN12_pd Subfamily PTPN12 63-322 1.3e-55 183.3 In-house 24-280 (290) alignment 
Range on Protein: 63-322
Range on HMM: 24-280/290.0
MRRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLEGPWPHE---YIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGA
... . ... .. .. ..  ||||||.   |..||.|.    .|   || ||..  .......| .|.|| ||  ||| | .. .|| . |.|. .| | 
ykaekvysteag.ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

KKCFEYFPSKKGDVMDFDEggQKISVKCESSVTYSFRADAkANVTATeiviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS----KGPIV
|||  |.|..... . |.|   ..... |  |.  |   .  .|.|         ...|| . .|...|||.|||..   .|||.|..|      . |.|
kkCerYWpeegeeelefge..fevtleeekavdddflirt.Lkveaq........kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlv

VHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDG--EKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
||||||.|||| .. ..|. ..| |..| ..    ...... .||.  .||  || .|.. ......|.
vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 71-324 2.2e-55 182.7 In-house 36-276 (288) alignment 
Range on Protein: 71-324
Range on HMM: 36-276/288.0
KMKAFkeAQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKK
 ...|   ... ..||... . |  ||||.   |. ||.|| |..  ...|.||.||||. |   .| |  .  |||| |||..|||| .|  ||||||.
iidsf..ianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl

GDVMDFDEGgqkisvkceSSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
|. . .             .|.   ||| .  |. . . |. .||..    . |...|.| |||   .. | |||  .  . |||||.|||.|||| ...
Gekarigrl.........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlil

LEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKL
   ....|     .   ...| |  |.| ..|||  |||.||...|...  || 
ilialeslrlddfl.girsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 43-331 1.2e-53 177.0 In-house 10-285 (288) alignment 
Range on Protein: 43-331
Range on HMM: 10-285/288.0
KFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
. |...  .  .|.  |.  .  ..  .. .| ..|. | ||||...  .| .||||..       .|| |.|..   . |..|.||.|| .|  ||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

CYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmDFdeGgqkisvkcesSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMA
 |..|.. | || ...|.| .|| ||.|...  .  .  |          |||   . . . . . .. .. .  .. ...|.|..  ||| |||.. . 
vyenktstivmltelveggktkCeeYWPdadkpk.ny..G..........svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskap

VLELL---ENARPSK-GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILnyfrkkKLMDESGVQ
.||||   ..| ... |||.||||||.||||  . |. ..|.. . . ||  . .. |. .||.. .||  || |...|.|      .|..| ||.
llellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvag.tvaklRkqRallvqtlkqYefiyevll......slieedgva
subfamily_PTPN3_pd Subfamily PTPN3 59-321 5.5e-53 174.7 In-house 20-277 (280) alignment 
Range on Protein: 59-321
Range on HMM: 20-277/280.0
EFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPhEYIHANYVATPTNP----KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
.|  . | .   ...| . .... ||||.|.   |. ||||.     .|| ||||    .     .|.| || ||.||..|||.| ...|.. | || . 
qfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttl

LEKGAKKCFEYFPSkKGDVMDFdeGgqKISVKCESSvtysfraDAKANVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSK--
.|.| .|| .|.|. ..| ...  |  ..|||||..       |.. ..   |.|..    .. || ..  . .||| |||     .||..|. |  .  
verGrvkChqyWPe.tedeley..g..efsvkceke.......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg

--GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
   |.|||||||||||| ...||  .  . | . .    .|. .. .|| . .|| .|| || . ||. ...
keePvvvhCsaGigrtGvlilletalalieaaepvyp.ldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 53-320 3.2e-52 172.6 In-house 21-284 (305) alignment 
Range on Protein: 53-320
Range on HMM: 21-284/305.0
PQGLRAEFVGMRRFNDfeKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
 .|| |..  . . ..  ...  |. ... |||.|..  ||..|..|        ..|| |.|| .  . |..| .|.||..| ||||.. .. ||. | 
dkgleaqykslyeeee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLCNFLEKGAKKCFEYFPSKKGDVMDFdeggQKISVKCESSVTYSFRADAKANVTATEIviegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN---
||..  | | .||  |.| .|.....|    ...||. .|. |.|     | ...  .       ...|  ..|.  |||| |||    ..|.|...   
mltklveggkdkCrqYWpesktekkef....gefsvelksektasdyieRklkisiede.....dkesrtvlqyqltdWPdhGvpqfatsllslikrvqk

-ARPSKG-PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
  . .|| |..||||||.||||  ....  ...| . ...|   ..| .. ..| . .|| .|| |.|... ..  
dqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdv.fevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_PTPN6_pd Subfamily PTPN6 38-325 8.5e-52 171.0 In-house 10-303 (306) alignment 
Range on Protein: 38-325
Range on HMM: 10-303/306.0
KKQILKFVQRTLEKMPQGLRAEFVGMRRF---NDFEKMKAFKeAQEAGKNRYKDVGCLDNNRVKL-EGPWPH-EYIHANYVA--TPTNPKRFICTQAPLE
.... .. . . ..  .|.  ||  ...    . ...... | .. . ||||| .   |..||.| |   |  .|| |||.   .... |..| ||  ||
eqrvselekeeeslekagfeeefeelqqeeakkllsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcle

KTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMdfdEGGQKISVKCE-SSVTYSFRADAKANVtateivieGPGEKTRKTTHYHWNDWP
.| .||| | .|.. . | |. . .|.| .||  |.|... . .    |  ...   | |  .| .|    ...          ....|.  .||...||
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskk........kkkkeerevfqyhfksWP

DRGVPAADMAVLELLENAR--------PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQII--DDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
| |||.   |||..||. .         ..|||||||||||||||...... .....    .    | .|.  .. |||.  .||..|| ||...| .| 
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

RKKKLM
..|| .
etkkkl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 81-312 2.5e-50 166.0 In-house 51-274 (301) alignment 
Range on Protein: 81-312
Range on HMM: 51-274/301.0
AGKNRYKDVGCLDNNRVKLEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFdeGG
  |.||. | |  .  |..        ||||.. |. .|.|||.||.||..|. ||| |. | .|| | ||....||  .|| ||.|.| .. .|   | 
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldi..gr

QKISVKCESSVTYSFRADAKANVTATEIVIegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLA
 || .| . ..        . .|. .   .     .||  ||| ...|.||||| . . . .|.| .. |. ||||||||||||. . .  ||.  ...|
fkikiknkelilnkkiskrtlevedstgkf.....atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea

GQIIDDGEkILVKICEQRNNSIQTDAQYLFVH
 . |.  |  | .. |.| |..||  |  .. 
dptielte.alkhlrehrwngvqtnsqlywmt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 33-319 3.6e-50 165.9 In-house 6-290 (298) alignment 
Range on Protein: 33-319
Range on HMM: 6-290/298.0
ERKQQKKQILKFVQRTLEKMPQGLRAEFVGMRRFND---FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATPTNPKRFICTQ
| .. |... |... . .|   |. .||  ... ..    |.... .. .   |||| |.  ||  || ||        .|| | .. . .. . || ||
eaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatq

APLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDfdeggqKISVkcessvtYSFRADAKANVTATEIVIE-GPGEKTRKTTHYHW
|||..| .||| |  ..... | || |  |..  |. .|.|... .  .      .|.|          . . .|... ... ..    ||.|.  . |.
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyg......eitv.......sllskeefadlivrklkvskkkeekerevrqlhf

NDWPDRGVPAADMAVLELLENARPS---KG--PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
  |||.|||.   .||.||.. | |    |  |..|.||||.||.|. . .. ..... . | .|   ...  . ..| ...|| .|| |.....|...
tsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDv.fqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 44-322 3.9e-50 165.5 In-house 5-279 (281) alignment 
Range on Protein: 44-322
Range on HMM: 5-279/281.0
FVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMC
 .... ..  .|.  |. ...  .  .  .| |. .   ||||...   |. |||.   |     .|| ||.|.. ...|..| ||.|. .....|| | 
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

YQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdvmdfdeggqkiSVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAV
.. ||. | |. . .|.|  ||  |.| ..             ..|    .  | .. .||.    .. .|  . .||. .. ..  ||| ||||  ...
weqkvsaivmvtreieagklkChrYWPddns............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkel

LELLENA----RP-SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
||  ..     .. .| |.|.|||||.||||. . |. ..... | .   | . .. .. ..||  .|| .|| ||....|... |.
lefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN23_pd Subfamily PTPN23 81-321 7.3e-50 164.4 In-house 44-282 (288) alignment 
Range on Protein: 81-321
Range on HMM: 44-282/288.0
AGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVA--TPTNPKrFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDE
. |||..|.   |.|||||.|    .|| | .|   .|. |. ||.|||||..| .||| | |..|.. | || .  |.| .|. .|.|..||. . |..
seknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd

ggqkISVKCESSVTYSfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--------RPSKGPIVVHCSAGIGRTGSVVM
    .|| ..|  . .        |  . ..   . ..... .| ... ||. ||||.   .|..|...        |.|| |.|||||||.|||| . .
....lsvtlksvrete......thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfal

LEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.  .. .| .|... |  ... ...||| ...|. .|. |. ...|.. |.
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 51-321 8e-50 164.7 In-house 17-282 (318) alignment 
Range on Protein: 51-321
Range on HMM: 17-282/318.0
KMPQGLRAEFVGM-RRFNDFEKMKAfKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVE
.    | .|.  . |  . . ..|.  |   . |||| ..   |. ||||.   |    .|| |||.   .. | .| .|||| .|. ||| | .. .  
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

YIFMLCNFLEKGAKKCFEYFPSKKGDVMDfdeggqKISVKCESSVTYSFRADAKANVTATEIviegpgEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN
 | || .  |.| .|.  |.|||.   ..      |. |. ...|..|     . .|| ||       |..|.   ||. .|||.|||.  . .|.|. .
vivmltqeeergkakvhryWPskgsrsyg......klvvelkeevelsdyvlrefkvtrtee......eesrqvrqyhytsWpdegvpesgaslldlvrq

A-----RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.     ....||||||||||.||||  .... ..... | ...|   ..  .. ||||  .||. || |...|.|..   
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPRG_pd Subfamily PTPRG 54-343 8.5e-50 164.5 In-house 19-314 (563) alignment 
Range on Protein: 54-343
Range on HMM: 19-314/563.0
QGLRAEFV--GMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEY
.|. .||    ..  ..  .... .. ..  |||| ..   |. ||||..       ..|| |||.      | || || ||..|. ||| | .. .|. 
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IFMLCNFLEKGAKKCFEYFPSkkGDVMDFDeggqKISVKCESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLE--
| |. |. |.|..||. |.|.   ......    ...|. ... . .  .  .  .  ...  .   .. .. ..||. .||| |||   . ||   .  
ivmitnlvergrrkcdvYWPk..desetyg....alqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

-NARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK--KLMDEsGVQE--AYDAFLE
  |...  ||||||||||.||||  ..|. .. |. . ....   ..| .|  |||. .||  ||.|.|...|.  . |  .|..|  |.|      .||
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavn.vfgflkhiraqRnflvqteEqYiflhdalleaiasketellae.qveelknctpyle

QYKK
|  |
qqyk
subfamily_Ptp69D_pd Subfamily Ptp69D 54-322 9.9e-50 164.4 In-house 22-289 (307) alignment 
Range on Protein: 54-322
Range on HMM: 22-289/307.0
QGLRAEFVGMRRFnDFEKMKAFKEAQ-EAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIF
.||  |.  . .   ..|   . | .  | ||||.|.   |..||||.   |    .|| |... .  . |.||. |.|.| |  ||| |  . .|. | 
fglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLCNFLEKGAKKCFEYFPSKkgDVMDFDeggqKISVKCESSVTYSFRADAKANVTATEIViEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA--
|| |  ||  |||  |.|    | . ..    .| ||. |. . |  .  . .|. ..    |  |..|| . ||.. |.|  || .  ..|.|.|..  
mlsnlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkee.sgevedsrkvvqyhytgWkDskvPevargllklieqvre

--RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
  . ...||||||||| ||.| .| |. ...|| | . .|  | .  .. .|||  .|  .|| |... .|.|  . 
lyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife.tvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 54-321 1e-49 164.1 In-house 5-270 (274) alignment 
Range on Protein: 54-321
Range on HMM: 5-270/274.0
QGLRAEFVGMRRFNDFEKMKAFKeaqEAGKNRYKDVGCLDNNRVKLEGPWPH----EYIHANYVATPT-NPKRFICTQAPLEKTCADFWYMCYQDKVEYI
. |..||. .    | |... |.   .. |||||..   .| || ||   ..    .|| |||.  .  . | .. || || .| |||| | ||..|. |
kdlekeflelPlnfdqeeldvfg...sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

FMLCNFLEKGAKKCFEYFPSKKGdvMDFDEGGQKISvkcessvTYSFRADAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENAR
 || .. |.  .|| .||| ...  .. .|  ....            .  . . . ...|..   . .|. .|| . ||||. .|    ..|.|... .
vmltklkeaneqkCavyfPdaed..yeiserygdve.......ikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleve

P-------SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
          .|.||||||||||||  .  .  . || . ...|   || ...  .|   .||. || ..|...  | ..
esreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 45-321 1.1e-49 164.2 In-house 14-285 (319) alignment 
Range on Protein: 45-321
Range on HMM: 14-285/319.0
VQRTLEKMPQGLRAEFVGMRRFNDFeKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCY
...  ..  ..|. ||  ..  ... ...  .. .   ||||...   |. ||.|   .|    .|| |... .  . ..|| ||||||.|  ||| | .
lkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

QDKVEYIFMLCNFLEKGAKKCFEYFPSKKgdvmdFDEGGQkISVKCESSvtysfraDAKANVTATEIVIEGPGEK--TRKTTHYHWNDWPDRGVPAADMA
....  . ||..  ||.  |. .|.|...     | |.|. . |. |.        . ....   .. ..   ..  ||. .|.....||| .||   ..
eeessivvmltklveklkvklkkywpeen.....feeyGr.livtleee.......eeledyiirklklnkkssevetRevkhfqyteWpdhdvPekats

VLELLENAR-----PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
.|.||.. |     ...||||||||||.||||. ..|. .....   ...|   ..  ..  |||  .|. .|| |.....|..   
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvf.stvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 74-338 1.8e-49 163.0 In-house 48-308 (310) alignment 
Range on Protein: 74-338
Range on HMM: 48-308/310.0
AFKeaQEAGKNRYKDVGCLDNNRVKLEG--PWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkG
|.|  ..  |||| || |||. ||||.      ..||||||| |    . |||.| ||..|  ||| | .|.. | |..||.  |.|  ||  |.||  |
ayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.g

dVMDfDEGGQKISVKCESSVTYSFRADAKANVTATEIVIEGPGE-KTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVM
 | .   |  ...  .|||  .     | . |     | | | . |  . .  .| .|||||||      .     |.  .|| |||||||..|.. || 
.vte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvva

LEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESGVQeAYDAFL
|.. .|.|  |. .|  |..  ..  .|   |||. |||....| . . | .. . |. .  . ||||
lklkidkldrglkvd.aeevktellksraiciqtelqyliidrvriifargetevaekill.ladafl
subfamily_PTPN1_pd Subfamily PTPN1 72-335 7.5e-49 161.0 In-house 24-285 (290) alignment 
Range on Protein: 72-335
Range on HMM: 24-285/290.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
... |. .. ..|||.||   |  |.|||     .|| |. |  .   ...| || || .|.. || | ...|   . || ...||.  ||..|.|... 
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-DVMDFDEGGQKISV-KCESSVTYSFRADAKANvtateivieGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPS------KGPIVVHCSAGIG
 . . ...   |. . . |.. .|  |     |            ..||. .|.|.  ||| ||| .  | |..| . | |      .|| |.|||||||
ekellledtklkvkliseerksyytvrllelen.........lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGSVVMLEYIMDQLLAGQI--IDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYfrKKKLMDESGVQEAYD
|.|...... .. .. . .     | .| |... ..|   |||  |  | .. ||.    |.....| ||. . 
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG..akvikgdssvqkrwk
0051429 (Phosphotyrosine protein) phosphatases II 106-342 1.6e-48 161.0 In-house 5-248 (272) alignment 
Range on Protein: 106-342
Range on HMM: 5-248/272.0
EYIHANYVATPTN---PKRFICTQAPLEKTCADFWYMcYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDF-DEGGQKISVKCESSVTYSFRADAKA
 ||.|..| ....   |.|......||. |.||||.. .. .. .|..|..  |.|. ||. | |  .  .... |.. . |.. . .  ..|.      
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

NVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADmaVLELLENARPsKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDD-------GEKILVKI
 ..  ..... . ...|. .|.|. ||||.|||     .|||||  .  .||..||||||..||| ||.| ... .. . .|.||        |... ..
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

CEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESGVQEAYDAFLEQYK
 .|| ...||..||||.....|...|.   .... .. |.||. |.| 
raqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyG
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 76-321 1.1e-47 157.2 In-house 16-266 (270) alignment 
Range on Protein: 76-321
Range on HMM: 16-266/270.0
KEAQEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVA-TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
. |...  |||.|.    . ||.||        .|| ||||.    ..|..|....||. |  .|| | .. ||. | |. .. ||| |||  |.|....
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DVMDFDEGgqKISVkcessvtYSFRADAKANVTATEIVIEGPGEKTRKTtHYHWNDWPDRGVPAADM------AVLELLENAR-----PSKG-PIVVHCS
. ... .|  ||.|        .     .    .|.. .|  ||. | . |...|.|||.||| ..        .|..|.. |      .|. |..||||
ekvkledg..kikv.......lalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGIGRTGSVVMLEYIMDQLLAGQIIdDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
||.|||| ...|....  |   . . |  .|. .. ..| . .|.  || |.......| ..
aGvgRtGtlialDiavrlLeetkkv.dvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPN13_pd Subfamily PTPN13 57-319 2.3e-47 156.5 In-house 14-269 (273) alignment 
Range on Protein: 57-319
Range on HMM: 14-269/273.0
RAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWPheYIHANYVATPTNPKRF--ICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
  ||  .| .   .. .  |....  ||||..|   |. ||||..  .  || |...  | . ...  | .| || .|..||| | .. |.| | |. . 
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

LEKGAKKCFEYFPSKKGDVMDFDeggQKISVKCESSVTYSfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR---PSK
 |||  ||  |.|..|.. .      ... |. .  . ..      . |  .  |..   ...|. .| .. .||| |||.. . .|... . |    ..
kekgkvkchrywPesknkklkvs...nrlevellkvqkld......gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||||||||||||.|... .. ... .   . .|  ..|. |. |||.  .||. ||.||...||. .
gPivvhcsaGiGrsGtlitidvvlglierdkefd.vkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 71-321 5.3e-47 154.8 In-house 28-271 (281) alignment 
Range on Protein: 71-321
Range on HMM: 28-271/281.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP----HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYF
   .|..  .  |||| .. |||  ||.|.   |     .||||||. .|   . .| || | ..| |||| | .|..   | |||.|||   .|| |||
lctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyf

PSKKGDVMDFDeggqKISVKCESSVTysfradAKANVTaTEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTG
| .   ...||    |.||. | |         |. || | . .   || ||  ||. |..|||  || .   .|..| . |    | |.|||||.||.|
prnahcclqfd....klsvsyedstv......nkslvt.trlnlsyege.trlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsg

SVVMLEYIMDQLLAGQIIDDGEKILVKI-CEQRNNSIQTDAQYLFVHQVILNYFRK
... .|  .. . .   . | ..|. ..    |  |.||  ||... .|.|..   
tlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
subfamily_PTPRA_pd Subfamily PTPRA 73-320 4.3e-46 152.3 In-house 51-296 (330) alignment 
Range on Protein: 73-320
Range on HMM: 51-296/330.0
KAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
.. .. ..  |||. ..   | .|| |   ||    .|| | ..    . ..|| .| |.|.|  ||| | .. |   | || .. |.  .||  |.|..
elaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde

kGDVmdfDEGGQKISVK-CESSVTYSFRadaKANVTatEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARP----SKGPIVVHCSAGIGR
 | |     |  ...|. .. .| |. |   |  |.  ..  .   .|.|  . .|.. ||| |||.  . .|.||.. .     | ||||||||||.||
.Glv...tyGnirvevedetvlvdytvr...kflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

TGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYFR
||. ..|. ..... | ...|  | .. ..  || . .||| || |...|.|.|. 
tGtfivldavlervkaerkvdvfe.fvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 40-344 4.9e-46 151.8 In-house 5-299 (312) alignment 
Range on Protein: 40-344
Range on HMM: 5-299/312.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGPWpHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYM
 | |.    .   || |  |.  .       .  ||   ..   ||| .. | |  |  | |     |||||.|   |.|.||.|||.|||.||. || .
mikkwasavmmstpqqltkeykavgnivsdsectaflkfkd..lnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwql

CYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmDFDEggQkiSVKCESSVTYSFRADAKANVT--ATEIVIEGPGEKTrKTTHYHWNDWPDRGVPAAD
.       | .|| |.| |..|| .|     | | |...  .   |  |.         .| ..|     .|.   |... |  || |  ||| |.| . 
alslgstsiillcgfvedgsekcakyisdivgfv.dled..h..rvyteycteieiggkskdkithrvlkvvvkatgqes.klnhyqwaswpdhgmpdsc

MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQiIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESgvQEAYDAF
 . | ||   .  | |.. |||||.||||.....| ..  |   .  ..  ...| .  .|  |... .||... ...|...  | |.  .  .. .  |
dtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrn..eqewtkf

LEQYKKV
 | | |.
ketyaki
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 76-319 8e-46 151.3 In-house 5-242 (250) alignment 
Range on Protein: 76-319
Range on HMM: 5-242/250.0
KEAQEAGKNRYKDVGCLDNNRVKLEGPW---PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKkCFEYFPSKKGD
|. |.  |||| |.  ||. || ||        .|| | .. . .. | || ||.||..|  ||| | ...|.. | || |. |.. . . .|.| .| .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

VMdfdeGgqKISVKCESSvtysfraDAKANVTATEIVIEGPGEKT-RKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTG
      |  .. |.  |.       . .|..| .....    ..  |   ..|.  |||.|||.   ||||||.. .       ..|..|.||||.||.|
ky....G..dvtvsllsk.......eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

SVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
. . .. ....|   ...|   |.. .. ..| ..... .|| ||...||.. 
afiaidavlerlkkekvvdv.fkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPRK_pd Subfamily PTPRK 69-317 1.6e-44 147.0 In-house 32-275 (314) alignment 
Range on Protein: 69-317
Range on HMM: 32-275/314.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEY
||   | |. ..  |||..|.   |. ||.|   .|    .|| |... . ..|. || || ||..| .||| . |...   | || .. |.|. || .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

FPSKKGDVMDFdeggQKISVKCESSVTYSFRADAKANvtateivIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAG
.| .     |.    .   |..|    .  |  .  .       .. . |..|.  ....  ||| .||    ..|.|. .      ...|.||||||||
WPedtevygdi....kvelvetellaelvvrifrvek.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaG

IGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILN
 ||||  .... ..| .   ...|   ..  ...... | ..|  || |...|||.
aGrtGtfiaidivldmieregvvdv.fnavktlrsrkvnmveteeqykfiydvile
0041856 (Phosphotyrosine protein) phosphatases II 82-323 9.3e-44 144.5 In-house 3-175 (182) alignment 
Range on Protein: 82-323
Range on HMM: 3-175/182.0
GKNRYKDVGCLDNNRvklegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgakkCFEYFPskkgdvmdfdeggq
 ||||.|. . |..|       .  ||.||... .  ..|||.||.|| .|.|||. | .. .. .| .|.         .. |.|              
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............

kisvkC-EssvtysfradakanvtateiviegpgekTRKTTHYHWNDWPDRGVPAaDMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQlla
       .                            .|  ..|..  ||| |||     .|...| .. ..||..||||||.||||..|.. ... .   
.....ell............................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...

gQiiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
 .   . |...  . ..|.....|  || |.....| ... ||
.g..vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 71-321 1.1e-43 144.4 In-house 35-279 (315) alignment 
Range on Protein: 71-321
Range on HMM: 35-279/315.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNfLEKGAK-KCFEYF
. .. .| ..  |||||..  ||..|||||       ..|| | |. .  . | .|..|.||. .  ||| | .|.||  | |. . ...| | ||  |.
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk.kqegdkikcrqyw

PSKKGDVMDFdeGgqKISVKcessvTysFRADAKANVTATEIvIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGI
| .|.| ..|  |  .|.|.     .  .  .| .. .| .. .   .|..|. | .....|||.||.    ..|.|. . . ..|    ...||||||.
Pdrkadsvef..G..sikve.....l..lsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGv

GRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|||| |. .. ...|.  .. .|   ... .. ..|   .||. .| |.....|...  
GrtGvvisidevvaqikrtrsvdvf.nfvknlrakrpylvqteeeyafiydavledllw
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 42-321 4.6e-43 142.1 In-house 8-285 (290) alignment 
Range on Protein: 42-321
Range on HMM: 8-285/290.0
LKFVQRTLEKMPQGLRAEFVGMRRFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE-----GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADF
 .||.    |  .| |..|  .  ..  ....     ..  .||....   |.||. |         ..|||.| |.    . |..| ||.|...| .||
gefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF

WYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgDVMDFDEggQKISVKCESSVTysFRADAKANVTATEiviegPGEKTRKTTHYHWNDWPDRG-VPA
| . .|.||  | ||.|  |.| .||  |.|..  |. ...|   .| .  |....       | .|. ..      ...... |.|.   |.. | |..
WkliwqekvtiivmltniieegkvkCqqYWpds..dtkayge..fsikllneetln..eyierklevknkn.....sagakqsvtqyqitnwdstgkvtn

ADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
    .| . |      .. ...||||||...||..  . ..  ...    . ||   ..| .   |. .|.||  || ...|..|.|. .
pqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidv.fqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 78-320 6.1e-43 141.7 In-house 41-277 (515) alignment 
Range on Protein: 78-320
Range on HMM: 41-277/515.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVM
  .  |||||..  .|..|||||       ..|. | |. .  | | .|..|.|.. .  ||| . .|..|  | |. .  |    || .|.| | || .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

DFdeGgqKISVKcessvTYSFRADAKAnVTATEIVIEgpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTGSVVM
 |  |  .|.|.     . |  |.. . .  .  |.   |...|  | .|...|||.|||    ..| |. . . ..|    |...|||||.|||| |. 
kf..G..sikve.....lvsleactgg.ikrkltvlk..gddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

LEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
.. .. .   ....|   ... .| ..|   .||. || |.....|... 
idsvvahakttrmvdvf.nfvtnirqkrpylvqtqeqyafiygavledll
subfamily_PTPN14_pd Subfamily PTPN14 66-321 2.3e-41 136.7 In-house 35-298 (300) alignment 
Range on Protein: 66-321
Range on HMM: 35-298/300.0
FNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPW--PHEYIHANYVATP--TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKK
 .   .... |  ..| |||.|||   ..|||.|       ..|| |  . ..  .. . .| .|.|||.|. ||| | ....|. | || .  |.| .|
kredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkek

CFEYFPSKKGDVMDFDEGgqkisvkcESSVTYSFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------------R
.|.|||...      . |        .  ||  |. |... .| .  .   | .. |.  |  ..||||.|||      |. ||.              .
sfkyfPkleskkktvefg........kfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnsevesk

PSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
 || |..||||||.|||| ... . ..  |  .. ||  .|.| .. |||   .|| ||| ||..|...|...
eskPPvlvhCsaGvGrtGvlilsdlliatlehneeid.ikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 40-321 5.5e-41 135.4 In-house 6-280 (287) alignment 
Range on Protein: 40-321
Range on HMM: 6-280/287.0
QILKFVQRTLEKMPQGLRAEFVGMRRFNDFEK-MKAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWY
.. .||..  .|  .| .  |. . . .. |. .      |   |||....   ||.|| |.|   ..|| | .. .  . |.|| ...|. .|  .|| 
kfgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWk

MCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdV-MdfdeGGQKISVKCESsvTYsfradAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRG-VPAA
.  . .|. | |||.  |.  ..|..|.|..|  | .    |  .|..  |   ..     |.  .   |.  ..  ..... . |.  .|...| |.  
liddrnvtaivmlcqekendeevcyqyWpeeks.vvl....Geyniellnee..vn.....agyierklevknknkagdkqqvkqyqitnWdstgkvtep

DMAVLELLE----NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
   .| . |    . ......||||||...||..  .  .  ...     .||   ..| .   |. .|.|| .|| |. ...|.|   
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD.vfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 69-321 3.2e-40 133.0 In-house 38-281 (315) alignment 
Range on Protein: 69-321
Range on HMM: 38-281/315.0
FEKMKAFKEAQEAGKNRYKDVGCLDNNRVKL---EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEY
.  ..  |. ..  |||| ..   |. ||.|   |     .|. ||..   . ..|.|..|.|.  .  ||| . .....  | || |  |.  .|. .|
lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky

FPSKkgdVMDFdeGGQKISVKCESSV-TYSFRADakanvtatEIVIegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENAR----PSKGPIVVHCSA
.| |    . .  |   .. | |     |. |.          .|    |.. |.   .|.  ||| |||.  .....|  ...     | |.|||||||
wpdk...kviy..Gkitvtrkseevnteytvrtl........svvf...gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
|.||||. . |. ..||. | ..||   ... .. ..| . .|. .|| |.....|. |  
GvGrtGtfitldavldqaeaenaidvy.nfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 82-329 6.1e-40 132.0 In-house 37-280 (285) alignment 
Range on Protein: 82-329
Range on HMM: 37-280/285.0
GKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNP-KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGG
  ||| || |... || |.    ..||||...  | .    .| || || .| .|||.| ||.|. |..||| ..| | .||  |.| | |.|. | .  
dlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkye

QKISvKCES-SVTYSFrADAkANVTATEIViegpGEKTRKTTHYHWNDWPDRGVPAADMAVLELL---ENARPSKGPIVVHCSAGIGRTGSVVMLEYIMD
  .. .|.  ... .   .|   |. ||        .     | .   |||.  |     ..||    ..  | . ||.||||||.||| ..| ..|   
itlt.eckeeaiagti.lna.ltvinteda....sseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

QLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKKLMDESG
...    |.    |. ..   | ...|.  |.||.. |...||  . ... .|
rimenpniem.ldivremramrfqavqshmqflflyvvlmeyfigegvvertg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 81-316 9.8e-40 131.2 In-house 4-236 (237) alignment 
Range on Protein: 81-316
Range on HMM: 4-236/237.0
AGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmdfDE
  |||| .. . | .|| |.|.    .|| |.|.      ||..|..| ||| .| ||| | .|.|   | ||  ..|.  .|| .|.|| .        
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ay

GGQKISVKC-ESSVTYSFRADAKANVTATEiviegpgeKTRKTTHYHWNDWPDRGVPAADMAVLELLEN----AR--PSKGPIVVHCSAGIGRTGSVVML
|   .|.|  |    |. |.   .. .  .        . |    |..  |||||||    |.| .  |    ..  .  || ..|||||.|||| ....
gvltvslkkkeefsdytvrslllskrltlk........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

EYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVIL
. .. |    ...|  .  .  | |.|   |||  ||.|.||.||
damlrqakekkvvdiyn.yvysieedrpyiiqtkdqyvfihqtil
subfamily_egg_pd Subfamily egg 65-341 2.5e-39 129.8 In-house 25-291 (307) alignment 
Range on Protein: 65-341
Range on HMM: 25-291/307.0
RFNDFEKMKAFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKgaKK
   | . ..   .. .  | | | | | |  |||||   | .  ..||||.|        ||..||||  |  ||| | .|..|.|| ||    |   ..
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CFEYFPSKKGDVMDFDEGGQKISvkCessVTYSFRADAKANVTATEIviEGPGEKTRKTTHYHWnDWPDRGVPAADMAVlelLENARPSKGPIVVHCSAG
|  |.|  . | . .  |. .|   .   .    .||   .||   .   |. .. |   |. . |.   .     . |   |  .|    |.||..  |
ceyywpkaesdslvtvpGslrie..n...lkvdskadplfrvtklkl..vGgddeerflehwqg.dvnnssdvysplrv...lrklrnlskpvvvqdilG

IGRTGSVVMLEYIMDQLLAGQIIDDG-EKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKkLMDESGVQEAYDAFLEQY
. .....| .|  . .|| | |      .  | .  .|. |...  .||||....| .||   .     ..  |. .||..
vskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv.igsakeldvdyerwleer
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 78-318 2.6e-39 130.4 In-house 59-290 (319) alignment 
Range on Protein: 78-318
Range on HMM: 59-290/319.0
AQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgAKKCFEYFPSKKgdvm
 |.  |||. ..   |.|.||||   |    .|| | .|.   .....| .| ||. | |||| | .. ..  | .|        .|| .|.| |     
dqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplki....

DFDEGGQKISVKcesSVTYSFRadakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSV
.  |.  |..|.   ||. .        |   |.  .|  .  || | .|.  ||| |||   . .. |...          . .||||||||.||||  
vikeerfkvkvd...sveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

VMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
..|. ..|..   . .|   ...  . .|||. .|  .|| |..  .|. 
ivldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 79-318 6.2e-39 129.2 In-house 24-254 (284) alignment 
Range on Protein: 79-318
Range on HMM: 24-254/284.0
QEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCnflekgAKKCFEYFPSKKgdvmD
|.  |||. ..   |.|.||||   |    .|| | ...   .....| || ||. | |||| | .. ..  | .|        .|| .|.| |     .
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki....v

FDEGGQKISVKcesSVTYSFRadakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLEN------ARPSKGPIVVHCSAGIGRTGSVV
  |.  |..|.   ||. |        |   |.  .|  .. || . .|.  ||| |||   . .. |...          . .||||||||.||||  .
ikeerfkvkvd...sveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

MLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNY
.|. ..|..   . .|   ... .. .|||. .|  .|| |..  .|. 
vldvlldrmkeekqvdvy.nfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 80-317 1.2e-38 127.7 In-house 48-277 (439) alignment 
Range on Protein: 80-317
Range on HMM: 48-277/439.0
EAGKNRYKDVGCLDNNRVKL-EGP-WPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAkkcfeYFPSKkGDVMDF
.  |||||||| .|  || | | |  ||  || |||.    ..| .| ||.| ..|. ||| . .. |.  | ||.|..|        |.||. ..|.  
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd.aevcyg

DeggqkISVKCESSVTYSFRADAKANVTATeiviEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----ENARPSKGPIVVHCSAGIGRTGSVVML
|     |.|...  .     .    .|          .|| |   ..|.  |||. |||    ||..|      | .   ||.|||||||.||||... |
d.....iavrvdrnielpnyvirgfkvfne....rdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiial

EYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILN
.  ..|| . . .|  . |.  . .||.. .|. .||.|... .|.
dialeqlklenkvd.ikgivkvlrkqrkqmvqalcqyvfiynavle
0046846 (Phosphotyrosine protein) phosphatases II 101-320 2.4e-38 127.0 In-house 8-174 (176) alignment 
Range on Protein: 101-320
Range on HMM: 8-174/176.0
GPWPHEYIHANYVATPtnpkRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMdfdeggqkisvkcessvtysfradak
 ...  ||.||.....    |.|.||.||..|.|||. | .. .......|..  |.|  ||. |.|  ..  .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

anvtateiviegpgektrkttHYHWNDWPDRGVPAAD--MAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyimdqLLAGQIIDDGEKILVKICEQR
                     .|.. .||| |||  .  . .||....|. ..||..||||||||||| .|..      ||  .   . |..| .. |||
.....................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqR

N-NSIQTDAQYLFVHQVILNYFR
  ...||..|| |.....| ...
plgavqtpeQyrflyefellllk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 78-317 6.7e-38 125.2 In-house 31-264 (283) alignment 
Range on Protein: 78-317
Range on HMM: 31-264/283.0
AQEAGKNRYKDVGCLDNNRVKLEgPWPHEYIHANYVA---TPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkGDvM
 ..  |||....   |..||.|. . ...|| | ..       . |..| .|.||..|  ||| | ...|.  | || .. |   .||  |.|.. |  .
denkrknrnqeivpadqwrvelk.sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr.Gs.e

DFdeGGQKISVKCESSVtYSFRADA-KANVTateivieGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELL-ENA-RPSKGPIVVHCSAGIGRTGSVV
|.  |   .... | .   ||       .|        .  ..|   .||  .|| . |  |    .  ....  .  .  |||||||||.|||||.  .
dy..Geftvtlrketts.nsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi

MLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILN
 .   ....|.  ..|   ...  . |||   .||  || .||...|.
aasasvkdaltesvvdv.favvkimreqrmmavqtldqyklvhelvle
0043147 (Phosphotyrosine protein) phosphatases II 105-313 1.7e-36 120.9 In-house 5-155 (172) alignment 
Range on Protein: 105-313
Range on HMM: 5-155/172.0
HEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFlekgakkcfeyfpskkgdvmdfdeggqkisvkcessvtysfradakanvt
. ||.|.|. ..  |.|||.||.||  |.|||| |... .. .|..|...                                                  
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

ateivIEGPGEKTRKTTHYHWNDWPDRGVPaADMAVLELLEN-----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllaG-QiidDGEKILVKICEQR
        |   .|   .|..  ||| |||     .||.||      |. ..||..||||||.|||| .|.. ...           . |...  . |.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl...sleeavalvrekR

NNSIQTDAQYLFVHQ
....|.. || |...
pgavqnpsqyrflyy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 72-321 5e-36 119.0 In-house 30-279 (287) alignment 
Range on Protein: 72-321
Range on HMM: 30-279/287.0
MKAFKEAQEAGKNRYKDVGCLDNNRVKL--EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
.|| .|  .. |||| ||  .|..|| |  ||    .|| |||||. |. ..||..|.|.  |  ||| . .. ..  . ..   .|.. .||..|.| .
fkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer

kGDVMDFdeGGQKISVkcessVTYSFRADAkaNVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA--D--MAVLEL---LENARPS--KGPIVVHCSA
    |    ||  . .     . |. .       . .  .|.  ....|    ... .|||.... .       ||.    .| || .   ||.|||...
.evPmrv..GGysvvl.....ldydikePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

GIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
||||.| .. .  ....|.    .|   ...... |.|.  .|.  |. .. . .  |.. 
GiGrsGillatlvlvsrledlGrvd.vaavvirlreyraalvqavvqlrllyealvtyykt
0036282 (Phosphotyrosine protein) phosphatases II 105-313 5.1e-36 119.3 In-house 2-164 (174) alignment 
Range on Protein: 105-313
Range on HMM: 2-164/174.0
HEYIHANYVATPTNPKRFICTQAPLEktcadFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSkkgdvmdfdeggqkisvkcessvtysfradakanvt
. ||.|...     ..|.|..|.||.     ||.|... ......||..  |.|  ||. |.|.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

ateivieGPGEKTRKTTHYHWNDWPDRGVPAADMaVLELLENARPS-----KGPIVVHCSAGIGRTGSVVMLEYIMDQLLagQIIDDGEKILVKICEQRN
        .   .|   .|..  |||.|||  .. .||... ..       .||..||||||.|||| .|.. ... .||  .  .|  ... ..  || 
.......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrp

NSIQTDAQYLFVHQ
...||. || |...
gmvqtpsQyrflyy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 61-321 1.7e-35 117.2 In-house 22-295 (301) alignment 
Range on Protein: 61-321
Range on HMM: 22-295/301.0
VGMRRFNDFEKMKAFkEAQEAGKNRYKDVGCLDNNRVKLEGPW-----PHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL
  ... .| . .  . . ...  ||.|..  .|.||. |.         .||| |.|.   .. |.|| .|.|..|| .||| . .|.|.  | |..|  
kelkegedksctvgl.seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlk

EKGAKKCFEYFPSKKGDVMDFDEGGQKISVKC--ESSVTYSFR---ADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELL-----E
|.  .||..|.|. . .  .| .   ... ..   . |  ..     |.  |      .      .... . ..  |||. ||      ||. .      
egtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihr

NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFRK
. ....||.|||||....|.|  . ..  ..|  |  ..|   ..   .  ..   ..|  || ....||  |.. 
qqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvf.qvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 80-320 3.2e-35 116.7 In-house 51-285 (297) alignment 
Range on Protein: 80-320
Range on HMM: 51-285/297.0
EAGKNRYKDVGCLDNNRVKLEGPWPH---EYIHANYVatPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNfLEKGAKKCFEYFPSKKgdVMDF
.  |.|||..   | .||||.    .   .|. | .|  ..| .|.|.|| | . | |||| | ....|  | || . .... |||  |.. |   |. |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlnd.dnerdkkcaryWsdkg..vttf

degGqKISVKCESSVtysfraDAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPA--ADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVV
   | ..||. .|        . .  .  .  | .|   ..|    |.. .|||. |.      ..|.|... |      ..||..|||.||.|||| ..
...G.dvsvvllsvs......ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

MLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
 .. .. .    . .|   ... |. ..| . .||. || ||....|... 
tidsvvaeakrekevdif.glvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 70-319 4.4e-35 116.3 In-house 38-288 (325) alignment 
Range on Protein: 70-319
Range on HMM: 38-288/325.0
EKMKAFKEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEyIFMLCNFLEKGAKKCFEYF
  .|.    ..  |||.|.|  ||..|| ||     |. .|| |.|. .  . . |. .|||| .|  |.| . .. .   . .. | |..| ..|  |.
iakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcs.vvvvlneldlgkdrcavyw

PSKKGDVMDFdeGGqkISVKCESSVTYSFRADAKANVTATEiviegpGEKTRKTTHYHWNDWPDRGVPA---ADMAVLELL----ENAR---PSKGPIVV
| . |.   |  ||  . ||  .  ..|     . .|  ..      . .||    ...  |.| ||.    . ...|.|.    |  .    . .||.|
pkemgksktf..Gg..levklrtieeisdyvhrvldvkqvk......kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilv

HCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYF
|||||.||||  . |  ......    .|  .  . |. ..| . ..|  || .... . ...
hcsaGvGrtGvfislysalakvieesrvdifg.fvkklrkdrpsmvetvdqyiliyealveay
0049772 (Phosphotyrosine protein) phosphatases II 81-323 5.1e-35 117.1 In-house 47-284 (314) alignment 
Range on Protein: 81-323
Range on HMM: 47-284/314.0
AGKNRYKDVGCLDnNRVKLeGP---WPHEYIHANYVATPtnpKRFICTQAPLEKTCADF----------WYMC--YQDKVEYIFM---------------
  ||||.|. . | |||.| .      . ||.|.|| ..   ..||.||.||| |. ||          | |   .. .| .| |               
rdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCNFLEKGAKKCFEYFPSKKgdvmdfdeggqkisvkcessvtysfradakanvtateI-------ViegpgekTRKTTHYHWNDWPDRGVPAAD
      |... ..|.  ......  |                                             .       .|   .|.. ..|| ..|  .
AlgKtpllildgngneptaadlellk.....................................eelydpelf.......erlgikylripvpDgsaplle

M--AVLELLENArPSKGPIVVHCSAGIGRTGS-VVMLeYIMDQLlagQIidDGEKILVKICEQRN-----NSIQTDAQYLFVHQVILNYFRKKK
.  ..||..|.| . .||..|||.||.||||. ||.  |.| .|   ..  . |..|  . ..|      ..|..  ||.|.....|.|....|
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa.ylmkll...gv..sleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 89-325 1.1e-33 111.7 In-house 27-257 (290) alignment 
Range on Protein: 89-325
Range on HMM: 27-257/290.0
VGCLDNNRVKLEG---PWPHEYIHANYVATPTNpKRFICTQAPLEKT-------CADFWYMCYQDKVEYIFMLCNFLEKGAK----KCFEYFPSKKGDVM
|  . ..|| |.|       .|||||.|  | .  |.| ||.|.||.         .||.|  |.||. . |||.| || |.     | .|.| . |. .
vpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

DFDEggqkISVKCessvtysFRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEyI
 |.     ..|||           .. .|   |.|..  .|.  . ||.  ..| .. |.     .|.|... . || |..|||  || |   .  .. .
kfkg....ltvkC.......kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.l

MDQLLAGQ-IIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILnyfrkkklM
  |..|..      |..| .. .||.. |... .. ||  .|.        .
gyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv........l
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 74-318 2.3e-33 110.1 In-house 39-235 (392) alignment 
Range on Protein: 74-318
Range on HMM: 39-235/392.0
AFKEAQEAGKNRYKDVGCLDNNRVKLE---GPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfeyfpskk
. ..  .  |||||..  .|..|||||       ..|. | |. .  | | .|..|.|   .  ||| | .|..|  | |. .. |              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

gdvmdfdeggqkisvkcessvtysfradakanvtateiviegPGEKTRKTTHYHWNDWPDRGVPAADMAVLELLENARPSKG----PIVVHCSAGIGRTG
                                           |...|  . .|. .|||..||    ..|..... .   |    |...|||||.||||
..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtg

SVVMLEYIMDQLLAGQIIDDgEKILVKICEQRNNSIQTDAQYLFVHQVILNY
 |. .. .. .    ...|   .....| ..|   .||. || |..  .|. 
vvisidsvvahakktrmvdv.fnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 76-316 8.2e-33 108.5 In-house 4-238 (239) alignment 
Range on Protein: 76-316
Range on HMM: 4-238/239.0
KEAQEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKG
|.  .  |||| ..   | .|| ||     || .|| |.|.     .|| .|.||  .| .. ||| | .|..   | ||  ..|   |||..|.|    
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

DVMDFDEGGQkisvKCESSVTYSFRADAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGS
   ..    .    | |    |  |.   ..|  ||          |   .||.  |||.|||    ||| |     ... |   | |.|||||.||||.
kycnlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtga

VVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVIL
..... .. |    . .|  .  .  | |.|   .||  ||.|.|  .|
flvidamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavl
subfamily_PTPRN_pd Subfamily PTPRN 41-315 8.3e-33 108.3 In-house 17-288 (297) alignment 
Range on Protein: 41-315
Range on HMM: 17-288/297.0
ILKFVQRTLEKmPQGLRAEFVGMRRFNDFEKMK-AFKEAQEAGKNRYKDVGCLDNNRVKLEGPWP---HEYIHANYVAT--PTNPkRFICTQAPLEKTCA
.|....  |.. .. |..|. .. ...  .. | . |. . . |||.|.|   |..||||.       ..|| |  .    | .|  .| ||.|| .| |
vlsyledhlkn.kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastva

DFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGG-QKISVKCESSVTYSFRadaKANVTAteiviegpgEKTRKTTHYHWNDWPDRGV
||| | ... |  | .|..  |.| |.| .|.| .  .| .. |       . |.  .  ||      |. .         ..||  | .|.  ||..||
dfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfy...lknlqt.........setrtvtqfhflswpeegv

PAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVI
||.  ..||.        |    |||||||.| ||||  .... ....|| |    |    | .. .||.. ..| .|. |. ...
PasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 79-317 8.8e-33 108.4 In-house 6-238 (239) alignment 
Range on Protein: 79-317
Range on HMM: 6-238/239.0
QEAGKNRYKDVGCLDNNRVKLEG--PWPH-EYIHANYVAT-PTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVM
 .  |||| ..   | .|| ||     || .|| |.|.     .|| .|.||  .| .. ||| | .|..   | ||  ..|   |||..|.|       
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

DFDEGGQkisvKCESSVTYSFRADAKANVTATEiviegpgekTRKTTHYHWNDWPDRGVPAADMAVLELL----ENARPSKGPIVVHCSAGIGRTGSVVM
..    .    | |    |  |.   ..|  ||          |   .||.  |||.|||    ||| |     ... |   | |.|||||.||||....
nlrvtlr....ktevfadyiirtfvmsqvgqte.........eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv

LEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILN
.. .. |    . .|  .  .  | |.|   .||  ||.|.|  .|.
idamlrqakkqktvdifn.yvkairedrphmvqtseqyvfihlavle
0049260 (Phosphotyrosine protein) phosphatases II 117-313 7.2e-32 105.6 In-house 6-144 (152) alignment 
Range on Protein: 117-313
Range on HMM: 6-144/152.0
TNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFpskkgdvmdfdeggqkisvkcessvtysfradakanvtateiviegpgek
 .|..||.||.|.. |.|||| | .. .. .| ||...||.|  || .|.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

trkttHYHWNDWPDRGVPAADMAVLELLEN----ARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllagqIIDDGEKILVKICEQRNNSIQTDAQYLFVH
     .|..  ||| |||  .. .|.||.     |. ..||..||||||.|||| .|.. ...          . |...  . |.|......  |. |..
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

Q
.
e
0044763 (Phosphotyrosine protein) phosphatases II 98-322 1.2e-29 98.6 In-house 11-174 (178) alignment 
Range on Protein: 98-322
Range on HMM: 11-174/178.0
KLEGPWPHEYIHANYVAtptnPKRFICTQAPlektcADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGdvmdfdeggqkisvkcessvtysfra
.|||..  .||.|...     |  ..... |     ||.. . .. .. .| .|.. || |  ||..|.|.. |                          
nleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

dakanvtateiviegpgektrktTHYHWNDWPDRGVPA---ADMAVLELLENAR-PSKGPIVVHCSAGIGRTGSVVMLEYIMDQllagQIidDGEKILVK
                        .|..  .|| |||      ....|..|.|. ...||..||||||.||.|..|.. ... .    ..  . |...  
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl..sleeaiel

ICEQRNnSIQTDAQYLFVHQVILNYFRKK
. |.|.  .... |. ..... | .. ..
vrerRp.ivpnpgqlrqLyefelrllkes
0051082 (Phosphotyrosine protein) phosphatases II 106-315 1.7e-28 94.5 In-house 4-149 (151) alignment 
Range on Protein: 106-315
Range on HMM: 4-149/151.0
EYIHANYVATPtnpkrFICTQAPLEktcaDFWYMCYQDKVEYIFMLCNFLEKGakKCFEYFPSKKgdvmdfdeggqkisvkcessvtysfradakanvta
 ||...||        ......||.    ||. . .. .. .|..|..  | |  .| ||.|.                                     
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

teiviegpgektRKTTHYHWNDWPDRGVPAADMAVLELLENARPS-KGPIVVHCSAGIGRTGSVVMLEYIMDQllagqiiDDGEKILVKICEQRNNSIQT
            .. .|... |||| |.|    ||||.|| ..   .||..||||||.|||| .|.|  .. .        . |..|  . ..| ...|.
............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp

DAQYLFVHQVI
  |.||.....
nqqflfqlfal
subfamily_CG7180_pd Subfamily CG7180 76-319 3.7e-28 93.0 In-house 38-290 (296) alignment 
Range on Protein: 76-319
Range on HMM: 38-290/296.0
KEAQEAGKNRYKDVGCLDNNRVK---LEGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAkKCFEYFPSKKgd
 ...  .|||. .|   |.|||    |.|    .|| | || . . .| .| |.|| ..|  .|| . |..... . .|..  .    .. .|.| |   
lrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..

VMDFDEggqkISVKCESSVTYSFRADAKANVT----ATEIVIEGPGEKTRKTTHYHWNDWPD-RGVPAADMAVLELLE-------NA--RPSKGPIVVHC
  .. |    | |.  .. .|.     .  .|    |.    ..   .||  .....  |.    ||    |..||..       ..  .| .||.||..
keqyge....ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

SAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHQVILNYF
| | .|.|  . ..  ....   . .|  |  . .. ..|.. ...  .| .. .|.|...
sdGasRsGvylaidanlelvekeeevdvFe.avktlrrsRpqLvenveeYkyiYdvlleav
PTPc_DSPc_SM00012 220-316 3.8e-28 93.1 In-house 2-104 (105) alignment 
Range on Protein: 220-316
Range on HMM: 2-104/105.0
TTHYHWNDWPDRGVPAADMAVLELLENARPSKG------PIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQ
 .|||...||| |||    ..||||.. . .|       |.|||||||.|||| .|.|.....|| ...  .| ..|. .. .||....||..||||...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VIL
..|
all
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 54-331 1.2e-27 91.1 In-house 26-296 (302) alignment 
Range on Protein: 54-331
Range on HMM: 26-296/302.0
QGLRAEFVGMRRF-NDFEKMKAFKEAQEagKNRYKDVGCLDNNRVKLEGpWPHEYIHANYVATPTNPKRFICTQAPLEKTC---ADFWYMCYQDKVEYIF
. ...||  .  .  | || ||||.  .  ||. .|| .||.|.||||.  | .|..|  |  |   .  | .| |  ..    ..|| | .|.|.  ..
aevkkefkkidtmkvdlekCkafkknlk..knqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvv

MLCNFLEKGAkKCFEYFPSKKGDVMDFdeggQKISVKCESsVTYSfrADAKaNVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMA----VLELLE
.|    |       |.|| | ||  ..    .|. |     | ..   ..| .  . |.. ||  .    .. |. . |..  ||    .    . .. .
ilvgeeelkk.tlselfpkksgdykey....gkmfvNnrk.Veka..eeek.tryviEvlPegcsnsvl.anvyvltnWkqkkvpvkyaeliktaakvfa

NARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEkILVKICEQRNNSIQTDAQYLFVHqVILNYFRKKKLMDESGVQ
.  ... ..|.    |.|| |... |   ...| .|.     | |. .| .|| .....  || ... ..|... |||. .... .
kkikadentvivSknGaGRagafltlavaveklqkgkepnike.ivksiRsqRpravdslkQyvsly.ialllyikkkvtkpeekk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 76-235 1.8e-27 91.0 In-house 26-181 (297) alignment 
Range on Protein: 76-235
Range on HMM: 26-181/297.0
KEAQ---EAGKNRYKDVGCLDNNRVKLEGPWP-HEYIHANYVATPTNPK--RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSK
  |.      ||||.|.   |..|||| .  . ..|| |.||. | ...  ..|..| ||..|  ||| . ... |  | |.... | | .||. |.|| 
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

KGDVMDfdeggqKISVKCESSVTYSfraDAKANVTATEIVIEGPgEKTRKTTHYHWNDWPDRGVPA
... .         .|  |   ..|   |   .|  ||. .    ...|. .|  .  ||| |||.
vqerlk......agdvvveflssts...defdrviltelqliyr.sesrvvrhvqflswpdhGvps
subfamily_ptpA1_pd Subfamily ptpA1 79-277 8e-27 89.0 In-house 46-255 (418) alignment 
Range on Protein: 79-277
Range on HMM: 46-255/418.0
QEAGKNRYKDVGCLDNNRVKLEG---PWPHEYIHANYVATpTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVmD
... |||| ..  ..  ||.|.        .|| |||.   . ||.||||| || .| |||| | .....  | ||    |.   ||  |.| . |   .
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.q

FDEGGQKISVKCESSVTY-SFRADAKANVTATEIVIEGPGEkTRKTTHYHWNDWPDRGVPAADMAVLELLENA-------RPS---KGPIVVHCSAGIGR
|   |.   |    ||       | . .. . .| .   || ||  |.|... |||. .|     . .|| .         ||   . ||.||||||.||
fsiygngnevfgtysvelveviqdpereiitrnirltfege.trditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGSVVMLEYIMDQ
||...    .| .
tgtfctavimmkk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 126-330 1.5e-25 84.3 In-house 97-294 (302) alignment 
Range on Protein: 126-330
Range on HMM: 97-294/302.0
QAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEGGQK-ISVKCEssVtYSFRADAKANVTATEIVIEGPGEKTRKTTH-Y
  |  .|.  .| .  | .|  .  ||.| |.. ||| ||.  | |... | .   | .||| .  .   |    .... . ||  |   .|..|| .  
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd..l.eeftdkksfklytveiknekkkkkvkktvdil

HWNDWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVIlnyfrKKK
..  ||| | |.   . |..|      |  ..||||||.||||..| . | . || . . . |  .|.. . . |  ..|.. | ...  ..      | 
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv.....tkg

LMDESGV
||.  ||
lmekagv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 130-328 8.2e-25 82.3 In-house 38-230 (255) alignment 
Range on Protein: 130-328
Range on HMM: 38-230/255.0
EKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESsvtysfrADAKANVTATEIVIE-GPGEKTRKTTHYHWNDW
  | . |. .  | | | . |||.| |.| .|| .||| .| . . . .    ..| .         . |.  . . ||. . |   ||.. .||... |
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad....vnvtttk.......ssadvvlrtleitstlgekkkthtvkhysykGW

PDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
...  |     .|..|  .| || ..|||||.||||. . |. |..  ...      . .. |  ..| .. ..|. .|.|  |  |   ..|...  |.
ieknaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

LMDES
 ... 
eleak
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 59-319 9.6e-23 75.5 In-house 11-259 (267) alignment 
Range on Protein: 59-319
Range on HMM: 11-259/267.0
EFVGMRRFNDFEKM-KAFKEAQEAGKNRYKDVGCLDNNRVKLEGPwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEK
||  ...  | .     .   . . .||. |.   |..|| |     .||| | || .    . || || ||..| .||. .  . ||  | .| .  . 
efelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd

gakKCFEYFPSKKGDVMDFDEGGQKISVKCESSvtysfradaKANVTATEIVIEgpGEKTRKTTHYHWNDWPDRGV------PAADMAVLELLENARPsk
   .   ..| | |.   ...   . |.. |             .. . |. ..   | ... | |... |           |   .   . |||. .  
...nirlfwPPkmgqakkyqdltvehslekeen.........dyqiitlelkfk..nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnr..

gPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDdGEKILVKICEQRNNSIQTDAQYLFVHQVILNYF
 |.||.||.|.||.|. ....  ....   .. |   . | || .||   ..|  .|...|... .| 
.PlvvacsdGvGrsGtflvidsqleraktegvsd.ifdflrkirsqriglvdtkeryiyihellaeya
subfamily_CG42327_pd Subfamily CG42327 105-250 1.1e-22 75.2 In-house 56-193 (319) alignment 
Range on Protein: 105-250
Range on HMM: 56-193/319.0
HEYIHANYVATPTN-PKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKkgdvmdfdEGGQKISVKCESSVTYSFRADAKANV
 ||..|.||  . . |  .|..|..||.. .||| . .. .   |  |..  |.| |.| ||.|.|        |...  |.  .  ||   |.  .  .
deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk........etldntslyGdilvtlkgrevkdrya

TATEIVIEGPGEKTRKTTHYHWnDWPDRGVPAADMAVLELLENARPS
..| .. .  .|..|. ||| . .|.. .||| . |.. .| ..| |
istlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
0048076 (Phosphotyrosine protein) phosphatases II 195-318 1.1e-21 72.4 In-house 22-142 (145) alignment 
Range on Protein: 195-318
Range on HMM: 22-142/145.0
FRADAKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQllaGQiiDDGEKIL
..  .. ..|.   .   .   .|. ..|.. .|||.|||   .  ...||..|.|....||..||||||.||||..|.. |.| .    .   . |..|
lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll...lg..vsleeal

VKICEQRNNSIQTDAQYLFVHQVILNY
 .. .|| ...... |. |.....| .
elvrsqrpgavpnpgqlrflyefelel
subfamily_hpo-7_pd Subfamily hpo-7 125-332 3e-21 70.5 In-house 39-242 (263) alignment 
Range on Protein: 125-332
Range on HMM: 39-242/263.0
TQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFDEggqkISVKCESSVTysfradakANVTATEIVIE--GPGEKTRKTTH
... | .| . |. .  | | | . |||.| |.| .|| .||| .| . . . .    ..| .  ..           .  |. ...  |   ||.. .|
lysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan....vnvcttkvqs........dvllktlellstlgeKkkthtvkh

YHWNDWPDRGVPAADMAVLELLENARPSKgPIVVHCSAGIGRTGSVVMLEYIMDQLLA----GQIID-DGEKILVKICEQRNNSIQTDAQYLFVHQVILN
| .. |...  |     .|..|. || || ..|||||.||||. . .. | .  ...      . .. |  ..| .. ..|. .|.|  |  |   ..|.
ysykgWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

YFRKKKLMDESG--VQE
.. .    .|     ||
fvlnnfakgeleakyqe
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 79-318 1.3e-19 64.9 In-house 46-278 (303) alignment 
Range on Protein: 79-318
Range on HMM: 46-278/303.0
QEAGKNRYKDVGCLDNNRVKLEGpwpHEYIHANYVATPTNpKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPsKKGDVMDFDE
..  |||. || |||  .|||       ||||.|.   .. |. | || || .|.|||| |  ..||  ...|    |         || .. | ..|.|
knmdknrfvdvicldhskvklsd...ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp.rnqdflkfee

ggQKISVKCESSVTYsfradakANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAAD--------MAVLELLENARPSKgPIVVHCSAGIGRTGSVVM
  . | |     |         ..  .  ..    |.       .|...||   .|.            .  .| .  .|. | |    .| ||.|.  .
..rsirvgefkrvel.......gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfal

LEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNY
.|     | . |   |  | | .. . |  ..|  .|. .|. .. ..
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
0048179 (Phosphotyrosine protein) phosphatases II 216-313 2.8e-19 64.7 In-house 45-139 (144) alignment 
Range on Protein: 216-313
Range on HMM: 45-139/144.0
KTRKTTHYHWNDWPDRGVP---AADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMdqllAGQiiDDGEKILVKICEQRNNSIQTDAQYLFVH
 .|  ..|.. .|||.|||   .   ..||..|.|....||..||||||.||||..|..  ..      .   . |..|  . ..| ...... |. |..
leregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgqlrfLl

Q
.
e
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 77-169 4e-18 60.3 In-house 44-153 (350) alignment 
Range on Protein: 77-169
Range on HMM: 44-153/350.0
EAQEAGKNRYKDVGCLDNNRVKLE-----------GPWPHEYIHANYVATP-----TNPK-RFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGA
  .   |||||..   . .||||.              . .|| |||.  .      ||. ..| ||||| .|  ||. .....||. | .| .  | . 
GvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

KKCFEYFPSK
.|| .|..  
ekcyrYWqeg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 216-318 1.9e-15 51.2 In-house 87-193 (440) alignment 
Range on Protein: 216-318
Range on HMM: 87-193/440.0
KTRKTTHYHWNDWPDRGVPAADMAVLELLENARP-----SKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGeKILVKICEQRNNSIQTDAQYLF
..|   .||.. |||.|||     ||.....        ..||..|||||| |||| .. .. |. .    . ||    ..  . ..| . .||  || |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidif.sfinsmrnnrpqmvqtpeqyaf

VHQVILNY
||...|. 
vheavleg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 241-317 1.1e-14 49.0 In-house 218-293 (297) alignment 
Range on Protein: 241-317
Range on HMM: 218-293/297.0
LELLENARPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILN
|| |. . | . ...||||||.||.| ||. . |...|  .  | |   || .. |||   .||  |. ......|.
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkk.ripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 248-320 1.2e-12 42.1 In-house 244-316 (319) alignment 
Range on Protein: 248-320
Range on HMM: 244-316/319.0
RPSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFR
| |.||.||||| |.|||| |.  .  . .|   .   |  ...  . ..| ....|  || |...|. .| .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 120-272 1.9e-11 38.5 In-house 4-155 (198) alignment 
Range on Protein: 120-272
Range on HMM: 4-155/198.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL-EKGAKKCFeYFPSKKGDVMDFdeGGqkISVKCESSVTysfRADAK-ANVTATEIVIEgPgEKT
.|.|.|| || .| |||| | ..    .| |. .   .| |   | |.|. .  .  .  |   .|| ... .|   ..|   . .  |. .   |   |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..gs..lsvttktitt...kpdytitaliltnntta.p.pst

RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLE
|. .|| .  | ..  |   . |  ..     |         |..|||| | | ||  | |.
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 120-272 2e-11 38.4 In-house 5-156 (199) alignment 
Range on Protein: 120-272
Range on HMM: 5-156/199.0
KRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFL-EKGAKKCFeYFPSKKGDVMDFdeGGqkISVKCESSVTysfRADAK-ANVTATEIVIEgPgEKT
.|.|.|| || .| |||| | ..    .| |. .   .| |   | |.|. .  .  .  |   .|| ... .|   ..|   . .  |. .   |   |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypf.ywpttesgtgky..gs..lsvttktitt...kpdytitaliltnntta.p.pst

RKTTHYHWNDWPDRGVPAADMAVLELLENARPS-------KGPIVVHCSAGIGRTGSVVMLE
|. .|| .  | ..  |   . |  ..     |         |..|||| | | ||  | |.
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvald
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 101-167 4.9e-11 36.5 In-house 86-154 (349) alignment 
Range on Protein: 101-167
Range on HMM: 86-154/349.0
GPWPHEYIHANYVATPT--NPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFP
.  ...|| |||.  .     |..|.|||||  |  ||. .   ..|. .. | .  |.. .||  |. 
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 251-322 6.5e-11 36.5 In-house 262-347 (350) alignment 
Range on Protein: 251-322
Range on HMM: 262-347/350.0
KGPIVVHCSAGIGRTGSVVMLEYIMDQL--------------LAGQIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
  ||.||||||.|||| .| |.... ..               | .. |  . |. .. .|| . .|.  |..|... .|.||. .
sspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfaLr
subfamily_eak_pd Subfamily eak 83-236 3.1e-10 33.9 In-house 55-197 (332) alignment 
Range on Protein: 83-236
Range on HMM: 55-197/332.0
KNRYKDVgCLDNNRVKLEGP--WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGAKKCFEYFPSKKGDVMDFdeGg
.| .| |   | . |.|      .  || |  .  .   ...| | .. |.    || | .. |   | .| . .|.. .|   ||| |  ....|  | 
rnvvkiv.pydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf..G.

qKISVKCESSVtysfradaKANVTATEIVIEGPGEKTRKTTHYHWNDWPDRGVPAA
 .. |.. . |        | |.  |  ..   |..| .  ||.   | .  .|  
.ildverkefv........krniletrllelskGnethrvlhykvfGwtettlpky
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 130-341 1.4e-09 31.0 In-house 128-331 (346) alignment 
Range on Protein: 130-341
Range on HMM: 128-331/346.0
EKTCADFWYMCYQDKVEYIFMLCNfLEKGAKKCFEYFPSkkgdvmdfDEGGQKISVKCessVTYSFRADAKAN--VTATEIVIEGPGEKTRKTTHYH--W
|    ||||| ||.... ....    .|  .     |          ..|| . . |    .    |||   .    . |.. ||  .      |.|  |
esfvedfwymiyqeqihlvylmvp.ddklkntttslfnd........enggyqytgkm...finnrradvsgdpkeytievlpegnsdsvicqvhhhapw

N--DWPDRGVPAADMAVLELLENARPSKGPIVVhCSAGIGRTGSVVMLEYIMDQLLAGqIIDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
.  . | . .|   |    | |.   . |  ||    | ||. | .   | ..||  | |  .  .|. .| .||  .... |||  .. ....|  .|.
khlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnng.iepniceimknikqqrpggvesfaqyasiyaivfdyiarkr

LMDESGVQEAYDAFLEQY
   .. |.   . |... 
ggkkapvnkdinrfidel
subfamily_PTPDC1_pd Subfamily PTPDC1 223-318 7.6e-09 30.3 In-house 85-175 (182) alignment 
Range on Protein: 223-318
Range on HMM: 85-175/182.0
YHWNDWPDRGVPAADM--AVLELLENARpSKGPIVVHCSAGIGRTGSVVMLEYIMDQLLagqiidDGEKILVKICEQRNNSIQTDAQYLFVHQVILNY
..   |.| ||.. .    .  ... |  ..| . ||| || |||| ..    .  . |      ..|| . .. ..| .||||  |  .|..  |  
vynfgwkDygvasleriLdivkvvafal.qegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksiqtreqvelvkefalfl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 190-322 1.4e-08 28.6 In-house 200-341 (347) alignment 
Range on Protein: 190-322
Range on HMM: 200-341/347.0
SVTYSFRADAKANVTATEIVIEGPGEKTRkTTHYHWNDWPDRGVPAADMAVLELL----ENARPS-------KGPIVVHCSAGIGRTGSVVMLEYIMDQL
.|.   |. .  |  . |.| ||  | |  .  |    || .  |     || |.     .. .|       . |.|| |  |. |. .||.   |..|.
avevdqrnknwmnkytvevvaegcseatf.akvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqv

LAGQIiDDGEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKK
|.|.   | .... |. .||   .     | .  .  | |.. |
ldgkt.pdcddlfkkmrdqragvftmsifytyairaalfylklk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 71-233 1.9e-08 28.2 In-house 87-235 (244) alignment 
Range on Protein: 71-233
Range on HMM: 87-235/244.0
KMKAFKEAQEAGKNRYKDVGCLDNNRVKL-EGPWPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfEYFPSK
 ||   . ... |||      .| ||| | .|     || | .|        .| || ||  |  ||| |  . .|. . .|    |.      ||.|  
vmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds

kgDVMDFDEGgqKIsvkcesSVTYSFRADAKaNVTATEIVIEGPG-EKTRKTTHYHWNDWPDRGV
  . ... |    |      .|| . | . | |. |... ||    |  .  | .   .||  | 
..eplewyee..di......tvtltdrdefk.nikasnleiesdmneshqaltmfqisnwpsdgt
DSPc Dual specificity phosphatase, catalytic domain 239-277 3.2e-08 28.5 Pfam-A 61-98 (133) alignment 
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |......  |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
DSPc Dual specificity phosphatase, catalytic domain 239-277 3.2e-08 28.5 In-house 61-98 (133) alignment 
Range on Protein: 239-277
Range on HMM: 61-98/133.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQ
.. | .|.|. ... ..||| ||| |......  |.|..
eavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmkt
PTPc_motif_SM00404 239-276 3.4e-08 28.5 In-house 68-104 (140) alignment 
Range on Protein: 239-276
Range on HMM: 68-104/140.0
AVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMD
.||. .|||. ..| ..||| ||. |......  |.|.
kvldfienaekkggkvlVHCqaGvSRSatliia.Ylmr
0038934 (Phosphotyrosine protein) phosphatases II 220-270 5e-08 28.3 In-house 67-134 (194) alignment 
Range on Protein: 220-270
Range on HMM: 67-134/194.0
TTHYHWNDWPDRGVPAADMAVLE------------LLEN-----ARPSKGPIVVHCSAGIGRTGSVVM
.. |. ......|.   .. . .             |.      .. ..| ..||| ||.|||| .| 
eryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_DSP19_pd Subfamily DSP19 229-278 5.7e-08 27.2 In-house 67-115 (152) alignment 
Range on Protein: 229-278
Range on HMM: 67-115/152.0
PDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMlEYIMDQL
|.  . .   ..|. .|.|| ..| ..|||.||. |. |||.  |.| . 
petdllsylkealdFieearskdgavlvHCnAGvSRsasvvi.aylmkke
PTEN_1 217-269 7.1e-08 27.5 In-house 91-148 (196) alignment 
Range on Protein: 217-269
Range on HMM: 91-148/196.0
TRKTTHYHWNDWPDRGVPAADMAV--LELLENARP---SKGPIVVHCSAGIGRTGSVV
 ..   |.  ...| |.|  ..    .. .....    ... ..||| ||.||.| ||
fksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
subfamily_eak_pd Subfamily eak 247-323 1.5e-07 25.1 In-house 233-309 (332) alignment 
Range on Protein: 247-323
Range on HMM: 233-309/332.0
ARPSKGPIVvHCSAGIGRTGSVVMLEYIMdQLLAGQIIDD--GEKILVKICEQRNNSIQTDAQYLFVHQVILNYFRKKK
. ||  ||.  .. |  |.|  |... .. .|. ... .    |....|. ..|. |. .. |. |.....|.|.....
tppsfapii.qsarGsaraGvfvvidlli.rlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 80-154 2.7e-07 24.4 In-house 37-119 (347) alignment 
Range on Protein: 80-154
Range on HMM: 37-119/347.0
EAGKNRYKDVGCLDNNRVKLEgP---------WPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNF
.  ||| |||   |. || |  |          .. || | ..      | .| || || .|  ||| | .  ||  .  . . 
slsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 251-321 3.1e-07 24.0 In-house 265-346 (349) alignment 
Range on Protein: 251-321
Range on HMM: 265-346/349.0
KGPIVVHCSAGIGRTGSVVMLEYIMDqlL------------AGQIIDDGEKILV-KICEQRNNSIQTDAQYLFVHQVILNYFRK
  ...|||||| |||| .| |.....  .              ..  |   | | ..  || . .|  ||. .... .|.||. 
lstllvhcsaGcGrtGvlvtldllls..ileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfal
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 93-213 3.2e-07 22.2 In-house 58-178 (327) alignment 
Range on Protein: 93-213
Range on HMM: 58-178/327.0
DNNRVkLEGPwPHEYIHANYVATptNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLE---KGAKKCFEYFPSKKGDVMDFDEGGQKISVKCES
|| || | |    |..  .||    .   .|  ||| .|.    | .  .|..  .  ||   .       ||. |||..  . |. .     .|. |..
dnrrv.lcgs.deeffpgqyvrm..egaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkmeaelmkgtlsivcka

SVTYSFRAD-AKANVTATEIVIEGP
    |. |   . ..| .|.||.  
reglsmgatkyeleltdsevvidkn
subfamily_CDC14_pd Subfamily CDC14 236-277 4.3e-07 24.1 In-house 248-288 (328) alignment 
Range on Protein: 236-277
Range on HMM: 248-288/328.0
ADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
 |. | ..|| |  ..| |.||| ||.||||...   |.| .
sdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkh
subfamily_DSP1_pd Subfamily DSP1 227-277 6.9e-07 23.5 In-house 71-120 (163) alignment 
Range on Protein: 227-277
Range on HMM: 71-120/163.0
DWPDRGVPAADMAVLELLENARPSKGPIVVHCSAGIGRTGSVVMLeYIMDQ
| |.  . .  . |.| ..... ..| . .|| ||| |  ..... |.| .
DspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla.ylmkt
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 95-169 1.2e-06 22.9 In-house 8-72 (130) alignment 
Range on Protein: 95-169
Range on HMM: 8-72/130.0
NRVKlegpwPHEYIHANYVATPTNPKRFICTQAPLEKTCADFWYMCYQDKVEYIFMLCNFLEKGakkcfEYFPSK
.|..      ..||.|..|    . . .. ||.|| .|. ||| |  .  |. . .|    |.      ||.|  
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds
subfamily_DSP8_pd Subfamily DSP8 240-280 2.3e-06 21.3 In-house 82-121 (159) alignment 
Range on Protein: 240-280
Range on HMM: 82-121/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQLLA
 .| .. |. ..| ..||. ||| |  .|. . ||| .|  
svefidkaksengrvlvhvlaGisrsatva.iayimktlem
subfamily_DSP6_pd Subfamily DSP6 241-278 4.8e-06 20.2 In-house 83-119 (158) alignment 
Range on Protein: 241-278
Range on HMM: 83-119/158.0
LELLENARPSKGPIVVHCSAGIGRTGSVvMLEYIMDQL
.|....|| .|  ..||| ||| |.  | .| |.| .|
iefidearskkskvlvhClaGisrsvtv.tlaylmkkl
Y_phosphatase3 Tyrosine phosphatase family 218-271 6.3e-06 21.3 Pfam-A 95-144 (164) alignment 
Range on Protein: 218-271
Range on HMM: 95-144/164.0
RKTTHYHWNDWPDRGvPAADMAVLELLENarpSKGPIVVHCSAGIGRTGSVVML
... . . .. ...   .|  .|||.| .   ..||...||.||  ||| |..|
eeamaeayreilede.kkayrkvlealae...eegpvlfHCtaGKDRTGvvaal
subfamily_DSP10_pd Subfamily DSP10 240-277 8.1e-06 19.8 In-house 81-117 (159) alignment 
Range on Protein: 240-277
Range on HMM: 81-117/159.0
VLELLENARPSKGPIVVHCSAGIGRTGSVVmLEYIMDQ
 || .|.|| .   ..||| ||| |  .|| . |.| .
alefieearkkgsrvLvhCqaGisrsatvv.iaYlmkh