Gene F20B6.1 in Caenorhabditis elegans

Synonym: CELE_F20B6.1, F20B6.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf11
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP061_AA protein Get Run
CeleP061_AA_31-157 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 28-161 2.8e-95 313.6 In-house 129-262 (312) alignment 
Range on Protein: 28-161
Range on HMM: 129-262/312.0
RDNVGFVDLEDHRVYTESCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVL
 | ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||.|
sdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlal

IESMIAALRHPRKQNVKDSFVLLRKDRARSVRVI
|||||||||||||||||||||||||||||||||.
iesmiaalrhprkqnvkdsfvllrkdrarsvrvf
0050432 (Phosphotyrosine protein) phosphatases II 32-158 3.2e-28 94.4 In-house 161-282 (308) alignment 
Range on Protein: 32-158
Range on HMM: 161-282/308.0
GFVDLEDHRVYTESCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD--KKPVIAHCSAGVGRTGTLVLIE
|..  .. .|.. |...       .| .|.|.|... . .|.. ...|... .||||| |.| .   ..| .|.|   ..|.. |||||||||||.....
gsleygkftvtllseev.......lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfiald

SMIAALRHPRKQNVKDSFVLLRKDRARSV
 ..  |.. .. .| . .  ||. |. .|
llleqlekeggvdvfeavkklReqRpgmv
0036941 (Phosphotyrosine protein) phosphatases II 49-159 4.4e-27 90.6 In-house 147-261 (297) alignment 
Range on Protein: 49-159
Range on HMM: 147-261/297.0
IeiggkSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK------DKKPVIAHCSAGVGRTGTLVLIESMIAALR---HPR
.      .| .| |.|.|. . .|.. ...|... .|||||.|.| ..  ... .|.|      ...||. ||||||||.||..... |.  |.   . .
v.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeg

KQNVKDSFVLLRKDRARSVR
. .... .  ||. |. .| 
gvdileavkklReqRpgavq
0047943 (Phosphotyrosine protein) phosphatases II 34-158 6.3e-27 90.1 In-house 132-255 (273) alignment 
Range on Protein: 34-158
Range on HMM: 132-255/273.0
VDLEDHRVYTESCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK------DKKPVIAHCSAGVGRTGTLVL
.  .. .|.. |...       || .|.|.|... . ||.. . .|... .||||| |.| .   ... .|.|      ...||. |||||||||||...
ltygkftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfia

IESMIAALRHPRKQNVKDSFVLLRKDRARSV
.. ..  |.. .. .|.. . |||. |  .|
ldllldqlekeggvdvleavkllrsqRpgmv
0051299 (Phosphotyrosine protein) phosphatases II 35-158 2.3e-26 88.3 In-house 145-269 (288) alignment 
Range on Protein: 35-158
Range on HMM: 145-269/288.0
DLEDHRVYTESCTEieiggksKDKITHRVLKVVVK----ATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD----KKPVIAHCSAGVGRTGTLV
 ..| .|.. |...       .|..|.|.|.|. .     .|.. . .|... .|||||.||| .   ..| .|.|     ..||. |||||||||||..
tygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfi

LIESMIAALRHPRKQNVKDSFVLLRKDRARSV
... ..  |.. .. .| . .  ||. |  .|
aldllleqlekeggvdvleavkrlreqRpgmv
DSPc_SM00195 50-159 2.9e-26 87.7 In-house 139-246 (263) alignment 
Range on Protein: 50-159
Range on HMM: 139-246/263.0
EiggkskDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKK----PVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKD
.      |.|. |.|..  ... .. |...||. .|||||.||| .   .||.||||.|.    |.. |||||||||||.|.|....  |..  | ....
k......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdife

SFVLLRKDRARSVR
 .  ||| |...|.
ivkelRkqRpgmvq
PTPc_SM00194 50-159 2.9e-26 87.7 In-house 139-246 (263) alignment 
Range on Protein: 50-159
Range on HMM: 139-246/263.0
EiggkskDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKK----PVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKD
.      |.|. |.|..  ... .. |...||. .|||||.||| .   .||.||||.|.    |.. |||||||||||.|.|....  |..  | ....
k......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdife

SFVLLRKDRARSVR
 .  ||| |...|.
ivkelRkqRpgmvq
0039614 (Phosphotyrosine protein) phosphatases II 48-158 7.1e-26 86.8 In-house 165-272 (297) alignment 
Range on Protein: 48-158
Range on HMM: 165-272/297.0
EieiggksKDKITHRVLKVVVkaTGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK------DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQ
.       .| .|.|.|.|.   .|.. ...|.|. .||||| |.| ..  ..| .|..      ...||. |||||||||||....  |.  |.. .. 
h.......ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

NVKDSFVLLRKDRARSV
.|.. .  ||. |  .|
dvleavkelreqRpgav
0040438 (Phosphotyrosine protein) phosphatases II 42-159 7.7e-26 86.5 In-house 146-260 (317) alignment 
Range on Protein: 42-159
Range on HMM: 146-260/317.0
YTESCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD----KKPVIAHCSAGVGRTGTLVLIESMIAALRH
 . |..|       .. ||.|.|.|. . .... ...|... .||||| |.| |.  ..|.||..     ..||. |||||||||||..... |.  |..
tllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlek

PRKQNVKDSFVLLRKDRARSVR
 .. .|.. .  ||. |. .| 
eggvdveeavkelreqRpgavq
0046845 (Phosphotyrosine protein) phosphatases II 36-159 9.6e-26 86.2 In-house 132-258 (284) alignment 
Range on Protein: 36-159
Range on HMM: 132-258/284.0
LEDHRVYTESCTEieiggksKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD------KKPVIAHCSAGVGRTGTLVLI
..| .|.. |...       || .|.|.|... .  ||.. ...|... |||||| |.| .   ..| .|..       ..|.. |||||||||||....
ygdftvtllseev.......kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfial

ESMIAALRHPR---KQNVKDSFVLLRKDRARSVR
. ..  |.. .   . .| . .  ||. |  .| 
dllleqlekeglllgvdvleavkrlreqRpgmvq
0045450 (Phosphotyrosine protein) phosphatases II 42-158 1.7e-25 85.9 In-house 165-287 (307) alignment 
Range on Protein: 42-158
Range on HMM: 165-287/307.0
YTESCTEIEIggksKDKITHRVLKVVVK-ATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK------DKKPVIAHCSAGVGRTGTLVLIESMIAA
.|  ....|.    .|..|.|.|.|  .  ||.. ...|... .||||| |.| ... ... .|.|      ...||. |||||||||||....  |.  
ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrq

LRHPRK---QNVKDSFVLLRKDRARSV
|..  .    .. . . |||. |  .|
lekegtlldvdlleavkllreqRpgav
0040439 (Phosphotyrosine protein) phosphatases II 45-158 5.3e-25 83.9 In-house 117-229 (249) alignment 
Range on Protein: 45-158
Range on HMM: 117-229/249.0
SCTEieiggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK------DKKPVIAHCSAGVGRTGTLVLIESMIAALRHP
|...       ||..|.|.|... . .|.. . .|.|. .||||| |.| ... ... ||.|      ...||. |||||||||||....  |.  |.. 
svev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

RKQNVKDSFVLLRKDRARSV
.. .... . |||. |  .|
lgvdleeavkllrsqRpgav
0043336 (Phosphotyrosine protein) phosphatases II 51-158 7.3e-25 83.4 In-house 153-260 (278) alignment 
Range on Protein: 51-158
Range on HMM: 153-260/278.0
IggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDS
     .| .|.|.|.|. . .|.. . .||.. .||||| |.| ..  ..| ||..    ...||. |||||||||||..... ..  |.. .. .. . 
h....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleea

FVLLRKDRARSV
.  ||. |. .|
vkelreqRpgav
0042113 (Phosphotyrosine protein) phosphatases II 43-158 1.8e-24 81.9 In-house 110-226 (245) alignment 
Range on Protein: 43-158
Range on HMM: 110-226/245.0
TESCTEIEIggksKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK-----DKKPVIAHCSAGVGRTGTLVLIESMIAALRH
|  ....|.    .|..|.|.|.|. . .... . .||.. .|||||.||. ..  ..|..|.|     ...||. |||||||||||....  |.  |..
tvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

PRKQNVKDSFVLLRKDRARSV
 .. .. . .  ||. |  .|
elgvsleeavkelrsqRpgav
Y_phosphatase Protein-tyrosine phosphatase 35-159 2.1e-24 81.6 Pfam-A 89-221 (235) alignment 
Range on Protein: 35-159
Range on HMM: 89-221/235.0
DLEDHRVYTESCTEIEIG-GKS--KDKITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLV
. |... .|    ..|.   ..  ....| |.|..  |.. . . ....... .|||||.|.| .   .|. .|.|.|    .||. |||||||||||.|
peeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfv

LIESMIAALRHPRKQNVKDSFVLLRKDRARSVR
... ..  |.. .. .|..    ||| |. .| 
aldilleqleaeeevdvlqivkelRkqRpgmvq
Y_phosphatase Protein-tyrosine phosphatase 35-159 2.1e-24 81.6 In-house 89-221 (235) alignment 
Range on Protein: 35-159
Range on HMM: 89-221/235.0
DLEDHRVYTESCTEIEIG-GKS--KDKITHRVLKVVVKATGQ-ESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLV
. |... .|    ..|.   ..  ....| |.|..  |.. . . ....... .|||||.|.| .   .|. .|.|.|    .||. |||||||||||.|
peeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfv

LIESMIAALRHPRKQNVKDSFVLLRKDRARSVR
... ..  |.. .. .|..    ||| |. .| 
aldilleqleaeeevdvlqivkelRkqRpgmvq
0045098 (Phosphotyrosine protein) phosphatases II 36-158 3e-23 78.0 In-house 118-255 (278) alignment 
Range on Protein: 36-158
Range on HMM: 118-255/278.0
LEDHRVYTESCTEIeiggkskDKITHRVLKVVVK----ATGQESKLNHYQWASWPDHGMPDSC--DTAHRLLSAVKK-----------------DKKPVI
 .| .|...|....       |..|.|.|.|.      ..... ...|... .||||| |..   .   .||  ...                 ...||.
ygdftvtllseevl.......ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

AHCSAGVGRTGTLVLIESMIAALrhPRKQNVKDSFVLLRKDRAR-SV
 |||||||||||||..  |.  |  ... .. . .  ||. |   .|
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 54-162 3.8e-23 76.5 In-house 162-270 (290) alignment 
Range on Protein: 54-162
Range on HMM: 162-270/290.0
KSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKD
.  ..| ...| |  | .|.| ||.|..  ||||. .. |  .  |.| ...|   ||. |||||.|||||.| ||  .  | . .. .. |    ||. 
dkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrns

RARSVRVII
|. ||.| |
rlnsvqvdi
PTPc_DSPc_SM00012 77-159 1.1e-22 75.5 In-house 2-91 (105) alignment 
Range on Protein: 77-159
Range on HMM: 2-91/105.0
LNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKK------PVIAHCSAGVGRTGTLVLIESMIAALRHP-RKQNVKDSFVLLRKDRARSVR
..||.. .|||||.|...|   .|| |||| |.      ||. |||||||||||.|... ..  |..  .. .... .  ||| |...|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 41-131 3.7e-22 73.7 In-house 142-232 (307) alignment 
Range on Protein: 41-131
Range on HMM: 142-232/307.0
VYTESCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESM
  | | ... ..  . |.    | .. |. ...   ..|.||  |||.|.|.   ||  ||.||. |. ||. ||||||||.||.| |  .
pntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislv
0037934 (Phosphotyrosine protein) phosphatases II 52-157 6.5e-22 73.7 In-house 109-224 (243) alignment 
Range on Protein: 52-157
Range on HMM: 109-224/243.0
GGKSKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVK------------KDKKPVIAHCSAGVGRTGTLVLIESMIAALrhp
. ...|..|.|.|... .  ....    ||.. .|||||.|||..   ..|..|.            ....||. ||||||||||||...  |.  |   
seehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...

rKQNVKDSFVLLRKDRAR-S
 . .. . . |||. |   .
.gvdleeavkllreqRpgka
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 40-155 2.2e-21 70.9 In-house 152-267 (305) alignment 
Range on Protein: 40-155
Range on HMM: 152-267/305.0
RVYTESCTEIEIGGKSKDKITHRVLkVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPR
 |  ||......  ..| |.|. || |.  . ..  | .|| |  ||| |.| .  .   ||   .  | |.. |||||.||||..|..| ..  |   .
svkfessvtlkfrkdakakvtetvl.viegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagq

KQNVKDS-FVLLRKDRA
. .  |  .. .|..| 
iiedtdkilqkireqrn
subfamily_PTPRB_pd Subfamily PTPRB 60-156 4.1e-21 70.3 In-house 163-266 (293) alignment 
Range on Protein: 60-156
Range on HMM: 163-266/293.0
T-HRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD------KKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRK
. . . .. .. . .| |...|.. ||||||.|.. .|  ... .|..       |.|...|||||||||||.. .. .. |...    ..    . ||.
edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelRe

DRAR
.|. 
eRnl
subfamily_PTPRD_pd Subfamily PTPRD 57-157 5.3e-21 69.9 In-house 159-263 (564) alignment 
Range on Protein: 57-157
Range on HMM: 159-263/564.0
DKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVK----KDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRK
 ... | .|.  | . .  . ..... ||||||.|.|  .  .|.. |.    .|..|.. ||||||||||| . |..|.  ... .. ..     .|||
adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrk

DRARS
.|   
qRnam
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 56-159 1.1e-20 68.9 In-house 118-226 (250) alignment 
Range on Protein: 56-159
Range on HMM: 118-226/250.0
KDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK-----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLL
.  .|.|.||.  .   .|  . .... .||| |.|.   ..  ||. |..     ...||| .|||||||.|. . |....  |.. .. .| .    |
fadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvl

RKDRARSVR
|||| ..|.
rkdrphave
subfamily_PTPN13_pd Subfamily PTPN13 54-157 1.9e-20 68.3 In-house 145-251 (273) alignment 
Range on Protein: 54-157
Range on HMM: 145-251/273.0
KSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAV---KKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLL
. .|  . | |.|  ...|.  .. | ....|||||.| | .   .... |   ..|. |.. |||||.||.|||. |. ..  . . .. .||.    |
qkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrkl

RKDRARS
|. |   
reqrqgv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 46-160 2.3e-20 67.8 In-house 142-256 (288) alignment 
Range on Protein: 46-160
Range on HMM: 142-256/288.0
CTEIEIGGKSKDKITHrVLKVVVKATGQESK-LNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVK
|| .    .  ||. . |  . .. .|.|.. . .  .  |.|.|.|..  .  |||  .|. .||.. |.||||||||||.||  .. .|| .    ..
ctvvkkkradidklvk.vsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgir

DSFVLLRKDRARSVRV
  .  ||..| .....
sllaklreerfkaiqt
subfamily_PTPN12_pd Subfamily PTPN12 42-158 3e-20 67.3 In-house 139-260 (290) alignment 
Range on Protein: 42-158
Range on HMM: 139-260/290.0
YTESCTEIEIGGKSKDKITHRVLKVVVKatGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVK----KDKKPVIAHCSAGVGRTGTLVLIESMIAALRH
. | . . |   . .| .. | ||| ..  ... |.. ... .|||||.| | ..  .|...|.    ....|.. |||||||||||.. |. .  .|..
fgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellka

PRK---QNVKDSFVLLRKDRARSV
 .     .| |  . |||.||  |
ekipeeldvfdlvlelrkqraalv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 61-158 3.8e-20 67.0 In-house 138-247 (270) alignment 
Range on Protein: 61-158
Range on HMM: 138-247/270.0
HRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCD---TAH---RLLSAVK-----KDK-KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFV
... .. .. .|.| .| |... .|||||.| . |   ...   ..| ||.     .|| .|.. ||||||||||||.... .. .| . .| .|     
yiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiie

LLRKDRARSV
 |||||   |
elRkdRmalv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 63-159 6.7e-20 65.9 In-house 177-273 (305) alignment 
Range on Protein: 63-159
Range on HMM: 177-273/305.0
VLKVVVkATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQN-VKDSFVLLRKDRARSVR
.|..   . .|.  . | ||. ||| |.|    |.  ||||..  | |.. |||||.|||||.| || ..  .   ..   . .    || .|| |..
llnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 51-160 8.5e-20 66.0 In-house 153-264 (288) alignment 
Range on Protein: 51-160
Range on HMM: 153-264/288.0
IGGKSKDKITHRVLKVVvkATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVK----KDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDS
.. | ......| | ..   ...| ....||. .|||||.|.|      ||. ||    .| .|.| ||||||||||| . .. .| |...  . .| . 
veskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagt

FVLLRKDRARSVRV
   ||| ||  | .
vaklRkqRallvqt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 53-160 1.3e-19 65.4 In-house 149-261 (281) alignment 
Range on Protein: 53-160
Range on HMM: 149-261/281.0
GKSKDKITHRVLKVvVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAV-----KKDKKPVIAHCSAGVGRTGTLVLIESMIAAL-RHPRKQNVKDS
 ..| .  .|..|.  . .|.. .... .. .|||||.|..        ..|     || | |.. ||||||||||| . .. .. |. .. .. .||. 
eeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkav

FVLLRKDRARSVRV
   |||.|   |. 
vaelrkernlmvqt
0043147 (Phosphotyrosine protein) phosphatases II 67-158 4.6e-19 64.2 In-house 55-144 (172) alignment 
Range on Protein: 67-158
Range on HMM: 55-144/172.0
VVKATGQESKLNHYQWASWPDHGMPdSCDTAHRLLSAVKK-----DKKPVIAHCSAGVGRTGTLVLIESMIaalrhpRKQNVKDSFVLLRKDRARSV
.. ... |    .|.. .||||| | . .   ..|. ...     ...||. |||||||||||||..  |.      .. .. . . |.|. |  .|
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav
0041856 (Phosphotyrosine protein) phosphatases II 71-158 5.7e-19 63.8 In-house 73-154 (182) alignment 
Range on Protein: 71-158
Range on HMM: 73-154/182.0
TGQESKLNHYQWASWPDHGMPDsCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAAlrhprKQNVKDSFVLLRKDRARSV
.  |    .|.. .||||| ||  |...... .|.....||. |||||||||||||..  |.       . .. . . |.|. |  .|
ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 55-159 6.2e-19 63.3 In-house 165-274 (298) alignment 
Range on Protein: 55-159
Range on HMM: 165-274/298.0
SKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD-----KKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVL
.. ... | |||  | . .| .. . .. ||||.|.|    .   ||. |..      .|||| .|||||||.|| . |.|..  ... ..  | .    
efadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkv

LRKDRARSVR
|||.|. .|.
lRkkrpgavq
0051429 (Phosphotyrosine protein) phosphatases II 56-158 1.9e-18 62.6 In-house 100-208 (272) alignment 
Range on Protein: 56-158
Range on HMM: 100-208/272.0
KDKITHRVLKVVVK-ATGQESKLNHYQWASWPDHGMPDSCdtAHRLLSAVKKdKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQN--------VKDS
.. ...|.| .. .  .|.  .. |... .||||| |..    ..||... . ..||. |||||..||||.|..  ... . .    .        . . 
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

FVLLRKDRARSV
   ||. |. .|
veelraqrpgav
subfamily_PTPN3_pd Subfamily PTPN3 54-157 2e-18 61.3 In-house 150-257 (280) alignment 
Range on Protein: 54-157
Range on HMM: 150-257/280.0
KSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVL
... ..  | | .  |.| .| |. . |. .|||||.||. .   .... |.| .    .||. |||||.|||| |.|.|  .| . . .. .. |    
detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrt

LRKDRARS
.|  ||  
mrdqraml
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 56-158 2.9e-18 61.1 In-house 158-266 (305) alignment 
Range on Protein: 56-158
Range on HMM: 158-266/305.0
KDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTAHRLLSAVKK----DKK-PVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVL
    . | ||. .. . .||  . .||  .|||||.|..  .  .|.  |.|    ||. |.. ||||||||||. . .. ..  |..    .| .    
asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkq

LRKDRARSV
||. |   |
lRskrmkmv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 56-159 3.3e-18 60.4 In-house 161-265 (301) alignment 
Range on Protein: 56-159
Range on HMM: 161-265/301.0
KDKITHRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDR
..||..| |.|.  .   ..  . |||...|.|.|.| |    . |.  ||| .||.. |||||.||. ...  | .  ..   .. ......  ||..|
nkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehr

ARSVR
 ..|.
wngvq
subfamily_PTPN14_pd Subfamily PTPN14 56-159 6.5e-18 59.7 In-house 164-280 (300) alignment 
Range on Protein: 56-159
Range on HMM: 164-280/300.0
KDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVK-------------KDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQN
 |... . ||.    ...| .. | |.. |||||.|.  ..    |  |.             . | ||. |||||||||| |.| . .||.| | .. .
sdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeid

VKDSFVLLRKDRARSVR
.| ..  ||. |   |.
ikkvlarLreqrmllvq
subfamily_PTPN23_pd Subfamily PTPN23 54-158 1.1e-17 58.8 In-house 150-263 (288) alignment 
Range on Protein: 54-158
Range on HMM: 150-263/288.0
KSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK--------DKKPVIAHCSAGVGRTGTLVLIESMIAALR-HPRKQNVK
.. ..  .||||. .. . .  .. | |. |||..|.|.| .|  ..| .|..         |.|.. ||||||||||.. |. . ...|. ..   .. 
retethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldii

DSFVLLRKDRARSV
. .  ||..|  .|
qvvsrlreqRrfmv
subfamily_PTPN6_pd Subfamily PTPN6 53-159 1.2e-17 58.9 In-house 163-281 (306) alignment 
Range on Protein: 53-159
Range on HMM: 163-281/306.0
GKSKDKITHRVLKVV-VKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK--------DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPR---K
 ||... . | |.|  .|  ..| .. .|.. ||||||.| . ..   .|. |..        .. |.. |||||.|||||...|. ..  ...     .
eksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldad

QNVKDSFVLLRKDRARSVR
 .....  ..|. |   |.
idiqklvksvreqrsglvq
0049260 (Phosphotyrosine protein) phosphatases II 68-158 2e-17 58.8 In-house 55-133 (152) alignment 
Range on Protein: 68-158
Range on HMM: 55-133/152.0
VkatgqesklnHYQWASWPDHGMPDSCDTAHRLLSAV----KKDKKPVIAHCSAGVGRTGTLVLIESMIaalrhpRKQNVKDSFVLLRKDRARSV
           .|..  ||||| ||. .    || ..    .....||. |||||||||||||..  |.      .. .... . |.|. |  .|
i..........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgav
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 58-155 2.1e-17 58.2 In-house 160-260 (319) alignment 
Range on Protein: 58-155
Range on HMM: 160-260/319.0
KITHRVLKVVVKATGQE-SKLNHYQWASWPDHGMPDSCDTAHRLLS----AVKK-DKKPVIAHCSAGVGRTGTLVLIESMIAALrhpRKQNVKDSFVLLR
..  | ||.  |..  |  .. |.|. .||||..|..  .   ||     ...| ...|.. ||||||||||| . .. |.  .   ....| | |   .
dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlerv...keegvlDvfstvs

KDRA
. |.
rlRt
0048076 (Phosphotyrosine protein) phosphatases II 63-157 2.4e-17 58.4 In-house 33-125 (145) alignment 
Range on Protein: 63-157
Range on HMM: 33-125/145.0
VLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAV---KKDKKPVIAHCSAGVGRTGTLVLIESMIAalrhpRKQNVKDSFVLLRKDRARS
|| .    .. | .  .|.. .||||| ||. ..  ..| ..    |...||. |||||||||||||..  |.      .. .. . . |.|. |  .
vlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpga
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 57-158 3e-17 57.7 In-house 157-263 (318) alignment 
Range on Protein: 57-158
Range on HMM: 157-263/318.0
DKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK-----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLR
.. . | .||  . . .. .   |...||||.|.|.|  .   |.  |.|     ...|.. ||||||||||. . .....  ...    .| .    ||
sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlr

KDRARSV
. |   |
eqrnlmv
0036282 (Phosphotyrosine protein) phosphatases II 71-157 4e-17 57.9 In-house 63-152 (174) alignment 
Range on Protein: 71-157
Range on HMM: 63-152/174.0
TGQESKLNHYQWASWPDHGMPDSCDtAHRLLSAVKKD-----KKPVIAHCSAGVGRTGTLVLIESMIAALRhPRKQNVKDSFVLLRKDRARS
.  |    .|..  |||||.||.    ......|..      ..||. |||||||||||||..  |.  |. .. ... | .  ||. | ..
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 45-155 1e-16 55.9 In-house 130-248 (274) alignment 
Range on Protein: 45-155
Range on HMM: 130-248/274.0
SCTEIEIGGKS-KDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK-----K--PVIAHCSAGVGRTGTLVLIESMIAALR
  ...||  .. ...  ..| |.|.| . .| .. || ...||||  ||. .|  .|.  |....     |  ||. |||||.||||  . |.  .  ||
rygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlr

HPRKQNVKDSFVLLRKDRA
.  . .|    . || || 
eeivvdvlkivcnlrldrG
subfamily_PTPN1_pd Subfamily PTPN1 54-154 1.7e-16 54.8 In-house 141-250 (290) alignment 
Range on Protein: 54-154
Range on HMM: 141-250/290.0
KSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVK------KDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRK---QNVK
..|.. | |.|..  . | .  .. |. . .||| |.|.|  .  ..|  |.      .|. |.. |||||.||.||..|...... . .  .    ..|
erksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdik

DSFVLLRKDR
. .. ||| |
kvllelrkyr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 60-158 1.7e-16 55.0 In-house 160-260 (315) alignment 
Range on Protein: 60-158
Range on HMM: 160-260/315.0
THRVLkvVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKK----PVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRA
..| |  |.. . .  ..  .|.  |||.| .    .  .|. .|| |..    ... |||||||||| .. |....| ... |  .| .    ||..| 
varkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrp

RSV
  |
ylv
0051082 (Phosphotyrosine protein) phosphatases II 74-153 1.7e-16 55.6 In-house 57-131 (151) alignment 
Range on Protein: 74-153
Range on HMM: 57-131/151.0
ESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD-KKPVIAHCSAGVGRTGTLVLIESMIaaLRhprkQNVKDSFVLLRKD
. .. |... .|||.|.|.| |.. ..|... .. ..||. |||||.|||||||..  |.  |.     .. . .  .|. 
gievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml..lg....vsleealeeyrlk
0048179 (Phosphotyrosine protein) phosphatases II 63-156 2.1e-16 55.4 In-house 33-126 (144) alignment 
Range on Protein: 63-156
Range on HMM: 33-126/144.0
VLKVVVKATGQESKLN--HYQWASWPDHGMPDSCDTAHRLLSAVK---KDKKPVIAHCSAGVGRTGTLVLIESMIaalrhPRKQNVKDSFVLLRKDRAR
|. .. .   .. . .  .|.. .||||| ||. .   ..| ...   ....||. |||||||||||||..  |.      .. .... . |.|. |  
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpg
0046846 (Phosphotyrosine protein) phosphatases II 51-157 3.1e-16 55.1 In-house 77-155 (176) alignment 
Range on Protein: 51-157
Range on HMM: 77-155/176.0
IggkskdkithrvlkvvvkatgqesklnHYQWASWPDHGMPDScDTAHRLLSAVK---KDKKPVIAHCSAGVGRTGTLVLIEsmiaALRHPRKQNVKDSF
|                           .|..  ||||| ||. .  ..|| ...   |...||. |||||.|||||||..      |.. .  .| . .
i...........................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveeal

VLLRKDRA-RS
 |.|. |  ..
alvreqRplga
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 58-158 3.8e-16 53.3 In-house 157-259 (515) alignment 
Range on Protein: 58-158
Range on HMM: 157-259/515.0
KITHRVLKVVvKATGqESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKD
  . | |.|. |       .  ...  |||.|.|  . .  .|. .|| |.     |.| |||||||||| .. |.|..|  .  |  .| .    .|..
ggikrkltvl.kgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqk

RARSV
|   |
rpylv
subfamily_PTPRA_pd Subfamily PTPRA 72-159 6.9e-16 53.0 In-house 188-279 (330) alignment 
Range on Protein: 72-159
Range on HMM: 188-279/330.0
GQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRARSVR
 ..  .. . . |||| |.|       .|| .||| .     |.. |||||||||||.. ...... ..  || .| .    ||. |.. |.
kksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvq
subfamily_Ptp69D_pd Subfamily Ptp69D 59-156 8e-16 53.0 In-house 178-267 (307) alignment 
Range on Protein: 59-156
Range on HMM: 178-267/307.0
IthrvlkvvvkatGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAV----KKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDR
.             .. |.  |.. .|.|  .|... .  .|.. |    |... |.. ||||||||.|..| ..|..  |.   | .. .    ||..|
v............edsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqR

AR
  
nl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 65-160 9.8e-16 52.9 In-house 174-276 (319) alignment 
Range on Protein: 65-160
Range on HMM: 174-276/319.0
KVVV--KATGQeSKLNHYQWASWPDHGMPDSCDTAHRLLSAV------KKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRAR
..    | ...  |.. . .  |||.|.||.     ||.  |      ........ ||||||||||. . .. ..  ... .. .| .    ||..| .
elsedgkekdi.rkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrnt

SVRV
 |. 
lvqd
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 62-160 1.3e-15 52.7 In-house 135-240 (284) alignment 
Range on Protein: 62-160
Range on HMM: 135-240/284.0
RVLKVVV--KATGQeSKLNHYQWASWPDHGMPDSCDTAHRLLSAV------KKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKD
| ...    | ...  |.. . .  |||.|.||.     ||.  |      ........ ||||||||||. . .. ..  ... .. .| .    ||..
rdielsedgkekdi.rkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqq

RARSVRV
| . |. 
rntlvqd
subfamily_PTPRG_pd Subfamily PTPRG 59-154 1.8e-15 51.2 In-house 168-266 (563) alignment 
Range on Protein: 59-154
Range on HMM: 168-266/563.0
ITHRVLKVVVKaTGQESKLNHYQWASWPDHGMPDSCDT----AHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDR
| .. ||   . . .| .  .|....||||| |..       ...   | |..  |.. |||||||||||.. .....  ...  . || .    .|  |
iknlklkkkkq.cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqR
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 76-143 2.1e-15 50.9 In-house 189-256 (302) alignment 
Range on Protein: 76-143
Range on HMM: 189-256/302.0
KLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNV
 ..  ....||||| |.  .||  .|   .  || |. ||||||||||||| |   |    . .  ..
tvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdl
0044763 (Phosphotyrosine protein) phosphatases II 72-155 2.7e-15 51.9 In-house 75-152 (178) alignment 
Range on Protein: 72-155
Range on HMM: 75-152/178.0
GqesklNHYQWASWPDHGMPDS---CDTAHRLLSAVK-KDKKPVIAHCSAGVGRTGTLVLIESMIAAlrhprKQNVKDSFVLLRKDRA
|      .|..  .|||| ||.   .. ..... ..  ....||. ||||||||.||||..  |.       . .. . . |.|. | 
g.....iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp
subfamily_PTPRK_pd Subfamily PTPRK 54-160 6.8e-15 49.7 In-house 150-259 (314) alignment 
Range on Protein: 54-160
Range on HMM: 150-259/314.0
KSKDKITHRVLKVVV--KATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMIAALRhprKQNVKDSF
. . .. .|...|    ..  .  .....|. .||||..| |  .  .|.  ||| .     ... ||||| ||||| . |....  ..   ...| | |
ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmie...regvvdvf

VLLRKDRARSVRV
   .. |.| | .
navktlrsrkvnm
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 60-158 1.4e-14 48.9 In-house 162-267 (297) alignment 
Range on Protein: 60-158
Range on HMM: 162-267/297.0
THRVLKVVVKATGQESKLNHYQWASWPDHGMPD--SCDTAHRLLSAVKKDK-----KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRK
 .| |.|   .. ..  .. ||. .|||. ..   |  .   |.| |.||       |.. ||.||||||| |. |.|..|  ..  . .. .    ||.
ikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrq

DRARSV
.|   |
erpylv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 68-158 9.2e-14 45.8 In-house 160-252 (281) alignment 
Range on Protein: 68-158
Range on HMM: 160-252/281.0
VKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALR-HPRKQNVKDSFVLLRK-DRARSV
.   |.   . |. |  |||  .|.| .   ..|  ..    | . ||||||||.|||. .|  . ... |    ..|.    ||   || ||
lsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 43-159 3.6e-13 43.7 In-house 158-274 (310) alignment 
Range on Protein: 43-159
Range on HMM: 158-274/310.0
TESCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDS-CDTA-HRLLSAVKKdkKPVIAHCSAGVGRTGTLVLIESMIAALRHPRK
.||  |.||   .   .   |      |  .| ...  .|  ||| |.||  | |   |||. |..   |.. |||||..|....| ..  |  |..  |
sesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvvalklkidkldrglk

QNVKDSFVLLRKDRARSVR
 ....    |.|.||  ..
vdaeevktellksraiciq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 51-161 7.5e-13 43.1 In-house 153-265 (315) alignment 
Range on Protein: 51-161
Range on HMM: 153-265/315.0
IGGKSKDKITHRVLKVVVKATGQEskLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDS
.  . ....| | | ||..   .|  .  ....|||| |.| .. .   |   ||. .     ... |||||||||||.. .....  .   .  .| . 
kseevnteytvrtlsvvfgdnire..vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynf

FVLLRKDRARSVRVI
   .|. | . |.|.
itgvrqnrikmvqva
0049772 (Phosphotyrosine protein) phosphatases II 74-143 8.3e-13 44.2 In-house 177-247 (314) alignment 
Range on Protein: 74-143
Range on HMM: 177-247/314.0
ESKLNHYQWASWPDHGMPdSCDTAHRLLSAVKK--DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNV
|    .| .  .||.. | . .   ..| ....  ...||. ||.||.|||||.|..  .. .|. . .. .
erlgikylripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 68-157 9.4e-13 42.9 In-house 127-222 (239) alignment 
Range on Protein: 68-157
Range on HMM: 127-222/239.0
VKATG--QESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMiaaLRHPRKQNVKDSFVL---LRKDRARS
.   |  .|  . .|... |||.|.|. . .   |   . ||     .| . ||||||||||....|..|   ||. .||.  | |     .|.|| . 
msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam...lrqakkqktvdifnyvkairedrphm
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 68-157 9.5e-13 42.9 In-house 128-223 (239) alignment 
Range on Protein: 68-157
Range on HMM: 128-223/239.0
VKATG--QESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMiaaLRHPRKQNVKDSFVL---LRKDRARS
.   |  .|  . .|... |||.|.|. . .   |   . ||     .| . ||||||||||....|..|   ||. .||.  | |     .|.|| . 
msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam...lrqakkqktvdifnyvkairedrphm
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 59-145 1.1e-12 42.7 In-house 116-209 (237) alignment 
Range on Protein: 59-145
Range on HMM: 116-209/237.0
ITHRVLKVVVKATGQESKLNH-YQWASWPDHGMPDSCDTAHRLLSAV-KK-----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKD
 | | | .... | .| .| | ||..||||.|.|. . .  |.   . ..     .  | | |||||||||| ...|..|.   .  .  .. .
ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiyn
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 62-160 1.3e-12 41.9 In-house 159-264 (439) alignment 
Range on Protein: 62-160
Range on HMM: 159-264/439.0
RVLKVVVK--ATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAV-----KKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDR
| .||. .   | .|  . .... .|||. .|  .     .| |.     |..  ||. |||||||||||.. ..  .  |.   | ..|    .|||.|
rgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqr

ARSVRV
 . |. 
kqmvqa
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 55-155 4.7e-12 40.4 In-house 157-260 (290) alignment 
Range on Protein: 55-155
Range on HMM: 157-260/290.0
SKDKITHRVLKVVVKAT-GQESKLNHYQWASWPDHGMPDSCDTAHRLLS-----AVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALrhpRKQNVKDSFV
. .....| |.|  | . |..... .||  .|...|      |   ...       |. ..... |||..|||..... ..  |      ... | | | 
tlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkc...ktegvidvfq

LLRKDRA
.|.. | 
vlksqRi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 71-156 4.7e-12 40.0 In-house 127-217 (392) alignment 
Range on Protein: 71-156
Range on HMM: 127-217/392.0
TGQESK-LNHYQWASWPDHGMPDSCDTAHRLLSAVKKDK----KPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRAR
 |.. .    .... |||...|    .  ...  || |     .|.| |||||||||| .. |.|..|  .. |  .| .  . .|. |  
kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 62-142 5.2e-12 40.4 In-house 101-186 (255) alignment 
Range on Protein: 62-142
Range on HMM: 101-186/255.0
RVLKVVVKA--TGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDkKPVIAHCSAGVGRTGTLVLIESMI----AALRHPRKQN
| |... .     .  ...||..  |...  |.       .| .|..  |.|. |||.|.||. ..||.|..      .|.     .
rtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetve
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 55-157 1e-11 39.4 In-house 152-257 (287) alignment 
Range on Protein: 55-157
Range on HMM: 152-257/287.0
SKDKITHRVLKVVVKA-TGQESKLNHYQWASWPDHG-MPDSCDTA---H-RLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESmiaALRHPRKQNVKDSFV
 ... . | |.|  |  .|.. ... || ..|...| ...        . .  .  |. . ... |||..|||..... ..    .... ... | | | 
vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaat...tinkckteGviDvfq

LLRKDRARS
.|.. | . 
vlksqriqk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 60-159 1.1e-11 39.5 In-house 163-272 (325) alignment 
Range on Protein: 60-159
Range on HMM: 163-272/325.0
THRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDT----------AHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVL
 ||||.|     |.   .. .|. ||.| | .    |           .  . |  |   |.. ||||||||||... . |..| . .  . .. ..   
vhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkk

LRKDRARSVR
|||||   |.
lrkdrpsmve
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 55-158 2.4e-11 38.3 In-house 139-242 (290) alignment 
Range on Protein: 55-158
Range on HMM: 139-242/290.0
SKDKITHRVLKVVVKaTGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALR-HPRKQNVKDSFVLLRKD
 .| . .| | |     ..| ...|..  .| .  ....  |.  |.. ||. | ||| ||  |. |  .|  |.     .     .....|    ||| 
keddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

RARSV
||  .
ralai
subfamily_ptpA1_pd Subfamily ptpA1 49-141 2.5e-11 38.0 In-house 162-262 (418) alignment 
Range on Protein: 49-141
Range on HMM: 162-262/418.0
IEIGGKSKDKITHRVLKVVVkaTGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKD----------KKPVIAHCSAGVGRTGTLVLIESMIAALRHP
.|.    . .|  | ... .   |.   . .||.  |||| .||  .  ..|| .. .           . |.| |||||||||||..    |.  | | 
veviqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhy

RKQ
 ||
fkq
subfamily_PTPN9_pd Subfamily PTPN9 108-159 3.2e-11 37.8 In-house 223-274 (297) alignment 
Range on Protein: 108-159
Range on HMM: 223-274/297.0
KKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRARSVR
. |.. |||||.|||||.. ..  .. |..  . .| ..  |||. || |..
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 35-143 4.1e-11 37.4 In-house 130-236 (285) alignment 
Range on Protein: 35-143
Range on HMM: 130-236/285.0
DLEDHRVYTESCTEIEIGGKSKDKIThrVlKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK---DKKPVIAHCSAGVGRTGTLVLIESm
 .  . .    | |  | |   . .|  |      |. .   .|| |   |||.  |. .     |   |||    .||.  ||||||||| |.| |.  
kfgkyeitlteckeeaiagtilnalt..v.intedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidy.

iAALRHPRKQNV
 |..|   . |.
.atirimenpni
subfamily_egg_pd Subfamily egg 59-162 1.4e-10 35.3 In-house 159-257 (307) alignment 
Range on Protein: 59-162
Range on HMM: 159-257/307.0
ITHrvLKVvVKATGQESKLNHYQWaswpDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMIA-ALRHP-RKQNVKDSFVLLRKDRAR
.|.  ||. | .  .|  |.|.|.    |        .  |.|  ...  |||. ..  || ...||| ||  .   || |  |. |. . |.||. |  
vtk..lkl.vGgddeerflehwqg....dvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrl

SVRVII
||  ..
svesvl
subfamily_hpo-7_pd Subfamily hpo-7 65-139 6.5e-10 33.3 In-house 113-189 (263) alignment 
Range on Protein: 65-139
Range on HMM: 113-189/263.0
KVVVKaTGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDkKPVIAHCSAGVGRTGTLVLIESMI----AALRHPR
... .   .  ...||..  |...  |       ..| ....  |....|||.|.||.   ...|..      .|.   
stlge.KkkthtvkhysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldtts
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 104-160 1e-09 32.7 In-house 224-280 (297) alignment 
Range on Protein: 104-160
Range on HMM: 224-280/297.0
VKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRARSVRV
 .  . ... ||||||||.| .|| . ..| ||. |  .|.     ||. ||| |. 
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 105-157 2.1e-09 31.8 In-house 189-238 (267) alignment 
Range on Protein: 105-157
Range on HMM: 189-238/267.0
KKDKKPVIAHCSAGVGRTGTLVLIESMIAALrhpRKQNVKDSFVLLRKDRARS
..  .|.. .||.||||.||.. |.|..  .   ....| | | .||| | . 
engnrPlvvacsdGvGrsGtflvidsqlera...ktegvsdifdflrkirsqr
0038934 (Phosphotyrosine protein) phosphatases II 79-127 2.9e-09 32.4 In-house 81-134 (194) alignment 
Range on Protein: 79-127
Range on HMM: 81-134/194.0
HYQWASWPDHGMPDSCDTAHRLLSAV-----KKDKKPVIAHCSAGVGRTGTLVL
.|    .||.| . | .. .| |..|     .. .. |  || ||.||||||| 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 75-156 3e-09 30.7 In-house 89-175 (440) alignment 
Range on Protein: 75-156
Range on HMM: 89-175/440.0
SKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK-----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRAR
  |..|.. .|||.|.|  .    ...  |..      . |.. |||||.|||| .. ..|..   ..  . ..      .|..| .
rtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 104-153 4.5e-09 30.1 In-house 261-310 (349) alignment 
Range on Protein: 104-153
Range on HMM: 261-310/349.0
VKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKD
 ...  ... ||||| ||||.|| ...... |  .... .|  .  |.||
dtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkD
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 103-134 5.3e-09 30.2 In-house 257-288 (350) alignment 
Range on Protein: 103-134
Range on HMM: 257-288/350.0
AVKKDKKPVIAHCSAGVGRTGTLVLIESMIAA
  ..  .|.. ||||||||||||| ..|..  
ldnarsspilvhCsaGvGrtGtlvtlDsllsd
subfamily_CG42327_pd Subfamily CG42327 102-160 7.7e-09 29.6 In-house 241-300 (319) alignment 
Range on Protein: 102-160
Range on HMM: 241-300/319.0
SAVKKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHP-RKQNVKDSFVLLRKDRARSVRV
|. .... |.. ||| ||||||...  .  |  | .. |  .. .    .|.|||..|. 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavlt
subfamily_PTPN9_pd Subfamily PTPN9 51-106 1.1e-08 29.4 In-house 149-204 (297) alignment 
Range on Protein: 51-106
Range on HMM: 149-204/297.0
IGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK
.  ..... ..|||..    |... |. |.|  ||||.|.|.|. .   .|..|..
veveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvre
PTPc_motif_SM00404 71-132 1.1e-08 30.0 In-house 43-104 (140) alignment 
Range on Protein: 71-132
Range on HMM: 43-104/140.0
TGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLIESMI
  .. .. ...        . .  | . . .....|... |. || ||| |..||.. . | 
ensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmr
subfamily_PTPRN_pd Subfamily PTPRN 75-156 3.9e-08 27.3 In-house 187-273 (297) alignment 
Range on Protein: 75-156
Range on HMM: 187-273/297.0
SKLNHYQWASWPDHGMPDSCDTAHRLLSAVKK----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPR-KQNVKDSFVLLRKDRAR
  .  . . |||..|.| |  .   .   | |       |.. |||.|.||||. .||. ... | .   . ..  .   || .|. 
rtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 54-160 4.7e-08 27.1 In-house 148-262 (287) alignment 
Range on Protein: 54-160
Range on HMM: 148-262/287.0
KSKDkITHRVLKVVvKATGQE-SKLNHYQWASWPDHGMPDSCDTAHRLLSAV---------KKDKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNV
|. .  . | |... .. ..|   .. ... ||||.... ..    |.   |          ..  |.. |...|.||.|.|. .  ..  |    . .|
kePe.ygvralrli.dletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdv

KDSFVLLRKDRARSVRV
    . ||. ||  |. 
aavvirlreyraalvqa
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 45-154 5.5e-08 27.2 In-house 64-179 (198) alignment 
Range on Protein: 45-154
Range on HMM: 64-179/198.0
SCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCD-----TAHRLLSAVKKD--KKPVIAHCSAGVGRTGTLVLIESMIAALRh
| |   |  |.   ||  .|   . |     .. |||..|| ..  |. .       | | .|   ..    ||| ||| | | || .| ..  . .   
svttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshe.

PRKQNVKDSFVLLRKDR
  |  | | | . .. |
esktsvvdlfevakrlr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 45-154 5.7e-08 27.2 In-house 65-180 (199) alignment 
Range on Protein: 45-154
Range on HMM: 65-180/199.0
SCTEIEIGGKSKDKITHRVLKVVVKATGQESKLNHYQWASWPDHGMPDSCD-----TAHRLLSAVKKD--KKPVIAHCSAGVGRTGTLVLIESMIAALRh
| |   |  |.   ||  .|   . |     .. |||..|| ..  |. .       | | .|   ..    ||| ||| | | || .| ..  . .   
svttktittkpdytitaliltnnttappstreishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshe.

PRKQNVKDSFVLLRKDR
  |  | | | . .. |
esktsvvdlfevakrlr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 60-149 8.3e-08 26.4 In-house 146-237 (283) alignment 
Range on Protein: 60-149
Range on HMM: 146-237/283.0
THRVLKVVVKATGQES-KLNHYQWASWPDHGMPDSCDTA---HRLLSAVKK-DKKPVIAHCSAGVGRTGTLVlieSMIAALRHPRKQNVKDSFVL
. . | . |... ...  | |||   | . |     ..     .. |  ..  | |.. |||.|.|||....   .. |.. . . . | | |  
iikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfi...aasasvkdaltesvvdvfav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 49-128 9.4e-08 26.1 In-house 164-246 (301) alignment 
Range on Protein: 49-128
Range on HMM: 164-246/301.0
IEIGGKSKDKITHRVLKVVVKAtgQESKLNHYQWASWPDHGMPDSCDTAHRLL-----SAVKKDKKPVIAHCSAGVGRTGTLVLI
. |   |... ..| .||  .   .  ..  .| ..||..|.     |  . .        | .. ||. |||..|.|.|. . .
vkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv
PTEN_1 80-154 1.4e-07 26.5 In-house 95-171 (196) alignment 
Range on Protein: 80-154
Range on HMM: 95-171/196.0
YQ--WASWPDHGMP---DSCDTAHRLLSAVKK--DKKPVIAHCSAGVGRTGTLVliesmIAALRHPRKQNVKDSFVLLRKDR
..    ...||| |     .| . .. .....  ... |. || ||.||.||.|     .| | . .| .... . |.|. |
veylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv.....aayLmykgkltadeAlelvrekR
DSPc Dual specificity phosphatase, catalytic domain 71-127 2.1e-07 25.9 Pfam-A 36-92 (133) alignment 
Range on Protein: 71-127
Range on HMM: 36-92/133.0
TGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVL
. .| .  ...     .  . .  . | . ........| |. || ||. |..||..
kkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 71-127 2.1e-07 25.9 In-house 36-92 (133) alignment 
Range on Protein: 71-127
Range on HMM: 36-92/133.0
TGQESKLNHYQWASWPDHGMPDSCDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVL
. .| .  ...     .  . .  . | . ........| |. || ||. |..||..
kkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
subfamily_PTEN_pd Subfamily PTEN 93-159 1.3e-06 23.5 In-house 101-164 (184) alignment 
Range on Protein: 93-159
Range on HMM: 101-164/184.0
SCDTAHRLLSAvkKDKKPVIAHCSAGVGRTGTLVLiESMIAALRHPRKQNVKDSFVLLRKDRARSVR
 ...... |..  ..|. |. || || ||||.|.    .. .|  ........ |   |   ...| 
ivediekwlee..dkknvvvvHCkaGkGRtGvliv.ayllkslllekaeealelfaeaRtknkkgvt
Y_phosphatase3 Tyrosine phosphatase family 94-128 2.3e-06 22.7 Pfam-A 110-144 (164) alignment 
Range on Protein: 94-128
Range on HMM: 110-144/164.0
CDTAHRLLSAVKKDKKPVIAHCSAGVGRTGTLVLI
 .. ...|.|. ....||. ||.||  ||| .. .
kkayrkvlealaeeegpvlfHCtaGKDRTGvvaal
0048567 (Phosphotyrosine protein) phosphatases II 87-127 6.3e-06 20.7 In-house 47-96 (157) alignment 
Range on Protein: 87-127
Range on HMM: 47-96/157.0
DHGmPDS-------CDTAHRLLSAVKKDKKPVIAHCSAGV---GRTGTLVL
|.| | .       .  ....|. ... .|... ||.||    |||.||. 
dfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig
subfamily_CG7180_pd Subfamily CG7180 77-156 9.4e-06 19.5 In-house 182-271 (296) alignment 
Range on Protein: 77-156
Range on HMM: 182-271/296.0
LNHYQWASWPD-HGMPDS----CDTAHRLLSAVKK-----DKKPVIAHCSAGVGRTGTLVLIESMIAALRHPRKQNVKDSFVLLRKDRAR
. ..|.  |.  . .| |     .  .|  . ..|     ...||. ..| |..|.|  . |.  .  ...  . .| .    ||..| .
vklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpq