Synonym: CELE_F20B6.6, F20B6.6
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_Cele-PTP-11_pd | Subfamily Cele-PTP-11 | 51-135 | 1.3e-61 | 203.0 | In-house | 1-85 (312) | alignment | ||
Range on Protein: 51-135
Range on HMM: 1-85/312.0
QRAEMIKKWASAVMMSTPQQLTKEYKAVGNIFPDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPEREI
|||||||||||||||||||||||||||||||..|||||||||||||||||||||||||||||||||||||||||||||||||| .
qraemikkwasavmmstpqqltkeykavgnivsdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfv
|
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0050432 | (Phosphotyrosine protein) phosphatases II | 49-129 | 2.5e-14 | 48.8 | In-house | 25-105 (308) | alignment | ||
Range on Protein: 49-129
Range on HMM: 25-105/308.0
KEQRAEMIKKWASavmMSTPQQLTKEYKAVGNIFPDSE--CTAFLKFKDLNRYPNIQCWDRGRFTLaGDENFYIHANFVKIC--T
| ...|.. . . ...| .|.... ...|. | .... . ||.|||..| ..|. | | .... ||.|..|...
klsvldllkllek...aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssk
|
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0036941 | (Phosphotyrosine protein) phosphatases II | 54-135 | 6.6e-13 | 44.1 | In-house | 5-81 (297) | alignment | ||
Range on Protein: 54-135
Range on HMM: 5-81/297.0
EMIKKWASAVMMSTPQQLTKEYKavgniFPDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPEREI
..|.. .| ... ..|.. .. .. ....... ...|||..| ..|. | | .... ||.|..|... . . |
llekllflalllkefeellplll.....lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfI
|
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0047943 | (Phosphotyrosine protein) phosphatases II | 69-135 | 6.7e-13 | 44.2 | In-house | 12-80 (273) | alignment | ||
Range on Protein: 69-135
Range on HMM: 12-80/273.0
QQLTKEYKAVGNIFPDSE--CTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPEREI
..| .|.... ...|. . .... . ||.|||..| ..|. | | .... ||.|..|. . .. . |
tllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfi
|
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0039614 | (Phosphotyrosine protein) phosphatases II | 63-131 | 8e-13 | 44.0 | In-house | 26-100 (297) | alignment | ||
Range on Protein: 63-131
Range on HMM: 26-100/297.0
VMMSTPQQLTKEYKAVGNIFPDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENF-----YIHANFVKICTK-P
.. ...| .|.. . ...|| ..... . ||.|||..| ..|. | | . ... ||.|..|. . .
ekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydllt
|
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0045450 | (Phosphotyrosine protein) phosphatases II | 54-127 | 3.2e-12 | 42.3 | In-house | 12-94 (307) | alignment | ||
Range on Protein: 54-127
Range on HMM: 12-94/307.0
EMIKKWASAVMMSTPQQLTKEYKAVGNIFP----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFVKI
... .. . . .. | ||.. . .. . . ....... ||.|||..| ..|. | | ... ||.|..|..
lkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrv
|
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0040438 | (Phosphotyrosine protein) phosphatases II | 62-135 | 4.6e-12 | 41.3 | In-house | 11-89 (317) | alignment | ||
Range on Protein: 62-135
Range on HMM: 11-89/317.0
AVMMSTPQQLTKEYKAVGNIFPD-SECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPEREI
...| ..| .|.. . ....| ....... ||.||||.| ..|. | | .. . ||.|..|.. .. . |
dllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfI
|
|||||||||
0051299 | (Phosphotyrosine protein) phosphatases II | 53-135 | 5e-12 | 41.3 | In-house | 7-95 (288) | alignment | ||
Range on Protein: 53-135
Range on HMM: 7-95/288.0
AEMIKKWASAVMMSTPQQLTKEYKAVGNIFPDSE--CTAFLKFKDLNRYPNIQCWDRGRFTLAG----DENFYIHANFVKICTKPEREI
.| . |. ..... . .| .|.... ...|| . .... . .. |||..| ..|. | | ... ||.|...... .. . |
veellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfI
|
|||||||||
0046845 | (Phosphotyrosine protein) phosphatases II | 71-128 | 3e-11 | 38.7 | In-house | 2-68 (284) | alignment | ||
Range on Protein: 71-128
Range on HMM: 2-68/284.0
LTKEYKAVGNIFP----DSECTAFLKFKDLNRYPNIQCWDRGRFTLAG-----DENFYIHANFVKIC
| .|.... .... . ....... ...|||..| ..|. | | ... ||.|..|. .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgy
|
|||||||||
subfamily_Cele-PTP-8_pd | Subfamily Cele-PTP-8 | 52-133 | 3.2e-11 | 37.8 | In-house | 2-83 (288) | alignment | ||
Range on Protein: 52-133
Range on HMM: 2-83/288.0
RAEMIKKWASAVMMSTPQQLTKEYKAVGNIFPDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKPER
. |.| | |. . . | |||. | . ..|.. .|| |. . | | | | .|||.|| | ..|
kkevinawirlvlqiaveglkkeyrdspneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrr
|
|||||||||
subfamily_Cele-PTP-6_pd | Subfamily Cele-PTP-6 | 55-135 | 7.6e-11 | 36.6 | In-house | 2-85 (307) | alignment | ||
Range on Protein: 55-135
Range on HMM: 2-85/307.0
MIKKWASAVMMSTPQQLTKEYKAVGNIFPD-SECTAFLKFKDLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPEREI
..| | . |.|. |.. . . |. || | ||| ...| |.|| . | |||||.. |..|| . |
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkfi
|
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0043336 | (Phosphotyrosine protein) phosphatases II | 73-135 | 2.8e-10 | 35.6 | In-house | 24-91 (278) | alignment | ||
Range on Protein: 73-135
Range on HMM: 24-91/278.0
KEY-------KavgnifPDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPEREI
.|. . .. ....... ||.|||..| ..|. | | .. . ||.|..|. .|.. |
lefeellsfkl......dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfi
|
|||||||||
0042113 | (Phosphotyrosine protein) phosphatases II | 86-135 | 1.5e-08 | 29.9 | In-house | 2-55 (245) | alignment | ||
Range on Protein: 86-135
Range on HMM: 2-55/245.0
ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPEREI
....... ||.|||..| ..|. |. | |. . ||.|..|. . ... |
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfi
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 71-131 | 1.9e-08 | 29.6 | In-house | 11-63 (278) | alignment | ||
Range on Protein: 71-131
Range on HMM: 11-63/278.0
LTKEYKAVGNIFPDSECTAFLKFKDLNRYPNIQCWDRGRFTlagDenfYIHANFVKICtkP
| |.. . .|. . .. .|. .|.|||..|...|. | | ||.|...... |
lefefllllgipseitpalylgnldknRykdilpydhsrVk...d...YINAsyidgy..p
|
|||||||||
0040439 | (Phosphotyrosine protein) phosphatases II | 84-135 | 4.2e-08 | 28.6 | In-house | 2-57 (249) | alignment | ||
Range on Protein: 84-135
Range on HMM: 2-57/249.0
DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPEREI
. ... ... ||.||||.| ..|. |. | . . ||.|.... . . | |
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfi
|
|||||||||
subfamily_Cele-PTP-18_pd | Subfamily Cele-PTP-18 | 49-135 | 8.4e-08 | 26.3 | In-house | 2-91 (305) | alignment | ||
Range on Protein: 49-135
Range on HMM: 2-91/305.0
KEQRAEMIKKWASAVMMSTPQQLTKEYKAVGNIFPDSECTAFLKFKD--LNRYPNIQCWDRGRFTLAGDE-NFYIHANFVKICTKPEREI
| |. | |. .. .|. | .|..|. . || . .. ||| .. | |. | | | |||||.| |.|.| |
kkqqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfi
|
|||||||||
DSPc_SM00195 | 76-135 | 2e-07 | 26.0 | In-house | 7-72 (263) | alignment | |||
Range on Protein: 76-135
Range on HMM: 7-72/263.0
KAVGNIFP--DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPEREI
. . . . ....... | |. ||| || . |. | | .| . ||.||..|. .|... |
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyI
|
|||||||||
PTPc_SM00194 | 76-135 | 2e-07 | 26.0 | In-house | 7-72 (263) | alignment | |||
Range on Protein: 76-135
Range on HMM: 7-72/263.0
KAVGNIFP--DSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDE----NFYIHANFVKICTKPEREI
. . . . ....... | |. ||| || . |. | | .| . ||.||..|. .|... |
ekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyI
|
|||||||||
0037934 | (Phosphotyrosine protein) phosphatases II | 87-128 | 2.1e-07 | 26.2 | In-house | 4-43 (243) | alignment | ||
Range on Protein: 87-128
Range on HMM: 4-43/243.0
CTAFLKFKDLNRYPNIQCWDRGRFTLAGdeNFYIHANFVKIC
. .. .. |||..| ..|..| | | . ||.||....
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvt
|
|||||||||
subfamily_PTPN13_pd | Subfamily PTPN13 | 69-130 | 8.7e-07 | 23.5 | In-house | 11-73 (273) | alignment | ||
Range on Protein: 69-130
Range on HMM: 11-73/273.0
QQLTKEYKAVGNIFPDSECTAFLK--FKDLNRYPNIQCWDRGRFTLAGDENfYIHANFVKICTK
|| ..|.| . .. | .|. | || ||| |. .|. | .| .. . || |...|.
qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpvg
|
|||||||||
subfamily_Cele-PTP-15_pd | Subfamily Cele-PTP-15 | 74-131 | 1.4e-06 | 22.5 | In-house | 16-73 (285) | alignment | ||
Range on Protein: 74-131
Range on HMM: 16-73/285.0
EYKAVGNIFPDSECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKICTKP
. | | . |. ||. ||||| ...| . | | . ||||..... |
qdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkd
|
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subfamily_Cele-PTP-20_pd | Subfamily Cele-PTP-20 | 52-127 | 1.8e-06 | 21.8 | In-house | 10-91 (290) | alignment | ||
Range on Protein: 52-127
Range on HMM: 10-91/290.0
RAEMIKKWASAVMMSTPQQLTKEYKAVGNIF-PDS--ECTAFLKFK--DLNRYPNIQCWDRGRFTLA-GDENFYIHANFVKI
..| ..|.|| |. ....|.||| . | | | | ||| .. | |. | | | . |.|||.||
qteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG
|
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Y_phosphatase | Protein-tyrosine phosphatase | 95-133 | 4.1e-06 | 21.8 | Pfam-A | 3-43 (235) | alignment | ||
Range on Protein: 95-133
Range on HMM: 3-43/235.0
DLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPER
. |||..| . |. | | .... ||.||.|| .....
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkk
|
|||||||||
Y_phosphatase | Protein-tyrosine phosphatase | 95-133 | 4.1e-06 | 21.8 | In-house | 3-43 (235) | alignment | ||
Range on Protein: 95-133
Range on HMM: 3-43/235.0
DLNRYPNIQCWDRGRFTL--AGDENFYIHANFVKICTKPER
. |||..| . |. | | .... ||.||.|| .....
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkk
|
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subfamily_Cele-PTP-4_pd | Subfamily Cele-PTP-4 | 60-128 | 4.3e-06 | 20.4 | In-house | 16-86 (302) | alignment | ||
Range on Protein: 60-128
Range on HMM: 16-86/302.0
ASAVMMS-TPQQLTKEYKAVGNIFPDS-ECTAFLKFKDLNRYPNIQCWDRGRFTLAGDENFYIHANFVKIC
| ... | . ....||.|.. .. | .|.|| | . |. ..... | . |.. ...|..| |..
akklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevP
|