Gene F20H11.4 in Caenorhabditis elegans

Synonym: CELE_F20H11.4, F20H11.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf15
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP064_AA protein Get Run
CeleP064_AA_104-378 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0036941 (Phosphotyrosine protein) phosphatases II 121-375 1.1e-72 240.1 In-house 18-275 (297) alignment
Range on Protein: 121-375
Range on HMM: 18-275/297.0
LMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLqnRPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEED
 ..... | .. .. .   ... ||.|| |||. | |||.|   ....|.|.|......| |...| .|||...||||||.||. .. . .||.....|.
efeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

GIQKCSRYIPSEDNISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PK--RPGPPVI
| .|| .| |.| . | ..| ...| ..  .. ..|. |  .|.. |...   .|..|.|.|...| || .| .  |.|......|.  ..  ..|| ..
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCSAGIGRTATLIGVDYGNQRIG---EVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
|||||.||..|.|..|.  |..    . |....|..|...|..|  |||.  |..|. .....
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 121-380 4.7e-72 238.3 In-house 20-279 (317) alignment
Range on Protein: 121-380
Range on HMM: 20-279/317.0
LMRD---FVALRAPsTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMIC
|..    .  |  . |.    .... .|.|| |||. |..||.|.. ..  |.|.|.|.....|. | ..| .|||...||||||.||. ..   .||..
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

DWEEDGIQKCSRYIPSedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGP
. ||.| .|| .| |.  . . ..| ...| .. ..  .|.. |  .|.. ...|   .|. |.|.|.. | ||..| .  ..|..|.|.|.   ...||
eleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgds...esrtvthfhytgWpdhgvppspdllldfleavrealedpggp

PVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLD
 ..|||||.|||.|.|....  ... . |...| ..|.|.|..| .|||.  |..|. ..... .   
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0050432 (Phosphotyrosine protein) phosphatases II 125-375 7e-72 237.7 In-house 51-297 (308) alignment
Range on Protein: 125-375
Range on HMM: 51-297/308.0
FVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLqnrPPDNDFIHANWMTMP---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGI
. ..  . .. .  .... .|.|| |||. | .||.|   ....|.|.|......    . ..| .|||...||||||.||. .. . .||... .|.|.
llsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengr

QKCSRYIPSEDN-ISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPGPPVIHCSAG
.|| .| |.| .  | ..| ...| .....  ..|. .  .|.. ....   .|..|.|.|.. | || .|    ..|..|...|.  ..|| |.|||||
ekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaG

IGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
.|||.|.| .|.  ... . |...|...|. .|..|  .||.  |..|. .....
vGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle

0045450 (Phosphotyrosine protein) phosphatases II 95-374 2e-70 233.3 In-house 2-301 (307) alignment
Range on Protein: 95-374
Range on HMM: 2-301/307.0
PPDTQELANKKKFCNWFFVDELDCKKLMRDFVALRAPSTC------VADTMKKHSEKCRYYDILCPDATRVVLQNRP---PDNDFIHANWMTMP------
.... .. . .|.. ..... ||.. ...       . |.       .  .... .|.|| |||. | |||.|.. .   .|.|.|.|.....|      
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdNISHVCGIYRITKIDQMTmvyaDVALQSFEISVTDKSLECPSLV
    | ..| .|||...||||||.|.. ..  ..||... .|.| .|| .| |.| . . ..| ...| .. ..    .  .. . . |||.. . .|. 
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh....ldgytvrtlevtdldgtgesrt

VKHYHFLKWRDHTAPMTSISVLKLLKALRD----PKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGE---MNVLDIVREMRQMRDKAVQSHHQFIFM
|.|.|...| ||..| .  ..|......|.     ...|| ..|||||.|||.|.|. ..  ... . |.   ...|..|...|..| .|||. .|..| 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

LMCIA
 ....
yeall

0039614 (Phosphotyrosine protein) phosphatases II 92-374 1.5e-68 226.7 In-house 12-286 (297) alignment
Range on Protein: 92-374
Range on HMM: 12-286/297.0
MKPPPDTQELANKKKFCNWFFVDELDCKKLMRDFValraPstCVADTMKKHSEKCRYYDILCPDATRVVLQNRP---PDNDFIHANWMTMPD--KFRYIS
.  | . ..|..... .| . . .|. ..|.. ..    .  ..    ... .|.|| |||. | .||.|.  .   .|.|.|.|......|  . ..| 
ipiplsvldlllllekansktllllefeellslkp....d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

AQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIqKCSRYIPSEDNishVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecpsLVVKHYHFLKWR
.|||...||||||.||. .. ...||... .|.|  || .| |.| .   ..| ...| .. ..  .... .  .|.. ...|     . |.|.....| 
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnnges.....rtvthfqytgwp

DHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
||..| .. ..|..|...|.      ..|| ..|||||.|||.|.|. ..  ... . |...||..|.|.|..| .|||. .|..|  ....
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

0046845 (Phosphotyrosine protein) phosphatases II 132-375 1.9e-68 226.2 In-house 18-272 (284) alignment
Range on Protein: 132-375
Range on HMM: 18-272/284.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD---NDFIHANWMTMP------DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQ
 .. .  .... .|.||.|||. | .||.|.. ..|   .|.|.|......       | ..| .|||...||||||.||. .... .||.....|.| .
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCSRYIPSEdNISHVCGIYRITKIDQMTmvYADVALQSFEISVTdkSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP----KRPGPPVIHCS
||..| |.| . . ..| ...| .. ..  . |. .  .|.. .  ... .|. |.|.|...| || .| .. ..|..|...|.     ...|| |.|||
kcaqYwple.gevltygdftvtllseev..kddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGIGRTATLIGVDYGNQRIGEVG---EMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
||.|||.|.| .|.  ... . |   ...||..|. .|..|  .||.  |..|  .....
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle

0051299 (Phosphotyrosine protein) phosphatases II 127-375 2.8e-67 222.5 In-house 34-284 (288) alignment
Range on Protein: 127-375
Range on HMM: 34-284/288.0
ALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQK
.| .. |. |  .... ||.||.|||. | .||.|.. ..  ..|.|.|..... . | ..| .|||...||||||.||. .. . .||.....|.| .|
sllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrek

CSRYIPSedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTD-KSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAG
| .| |.  . | ..| ...| .. ..  ..|. .  .|.. .|  . .  |. |.|.|...| || .| .  ..|..|...|.   ...|| |.|||||
caqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaG

IGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
.|||.|.| .|.  ... . |...||..|. .|..|  .||.  |..|  .....
vgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0047943 (Phosphotyrosine protein) phosphatases II 129-374 1.2e-66 220.3 In-house 25-269 (273) alignment
Range on Protein: 129-374
Range on HMM: 25-269/273.0
RAPSTCVADTMKKHSEKCRYYDILCPDATRVVLqnRPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
  . |. .  .... .|.||.|||. | .||.|   ....|.|.|....... | ..| .|||...||||||.||. .... .||.....|.| .|| .|
kplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqY

IPSEDNI-SHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSLecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD----PKRPGPPVIHCSAGIG
 |.| .  | ..| ...| ....|  ..|. .  .|.. .. .    |..|.|.|...| || .| .  |.|......|.     ...|| |.|||||.|
wpleggelsltygkftvtllseet..kddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
||.|.| .|.  ... . |...||..|. .|..|  .||.  |..|. ....
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

DSPc_SM00195 130-376 1.5e-66 219.8 In-house 14-261 (263) alignment
Range on Protein: 130-376
Range on HMM: 14-261/263.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 |...     || ..| || .||. | ||| |....  ...|.|.||.....  | .|| .|||...||||||.||. || . .||... ||.| .||.|
spketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YIPSEDNISHVCGIYRITKIDQMTMVyADVALQSFEISVTDKsleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR--PGPPVIHCSAGIGRT
| |.| . . . | .... ... ..  ... |. .|.. ..|     .  |..|.. .| || .| .  |||.||.|..  |.   || |.|||||.|||
ywpeesggketfgkisvklvevekkk.deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.|.. .|.  ... |  .... .||.|.|. | ..||.. |..|. ..|.. 
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 130-376 1.5e-66 219.8 In-house 14-261 (263) alignment
Range on Protein: 130-376
Range on HMM: 14-261/263.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 |...     || ..| || .||. | ||| |....  ...|.|.||.....  | .|| .|||...||||||.||. || . .||... ||.| .||.|
spketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YIPSEDNISHVCGIYRITKIDQMTMVyADVALQSFEISVTDKsleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR--PGPPVIHCSAGIGRT
| |.| . . . | .... ... ..  ... |. .|.. ..|     .  |..|.. .| || .| .  |||.||.|..  |.   || |.|||||.|||
ywpeesggketfgkisvklvevekkk.deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.|.. .|.  ... |  .... .||.|.|. | ..||.. |..|. ..|.. 
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

Y_phosphatase Protein-tyrosine phosphatase 143-374 1.7e-66 219.3 Pfam-A 2-234 (235) alignment
Range on Protein: 143-374
Range on HMM: 2-234/235.0
SEKCRYYDILCPDATRVVLQNRPPDNDFIHANWM-TMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIY
..|.|| |||. | ||| |.... ..|.|.||.. . ..|...| .|||...|.||||.||. ||  ..||... || | .||..| |.|.. |  .| .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

RITKIDQMTMVYADVALQSFEISVTDKSLecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGE
...   . .   ....|. .|.. ....    .  ||..|. .| ||..| .. |.|.|.....  |  . || |.|||||.|||.|.. .|.  ... .
kvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
 .|..||.||.|.|. | ..||| .|.||. ..|.
eeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 143-374 1.7e-66 219.3 In-house 2-234 (235) alignment
Range on Protein: 143-374
Range on HMM: 2-234/235.0
SEKCRYYDILCPDATRVVLQNRPPDNDFIHANWM-TMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIY
..|.|| |||. | ||| |.... ..|.|.||.. . ..|...| .|||...|.||||.||. ||  ..||... || | .||..| |.|.. |  .| .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

RITKIDQMTMVYADVALQSFEISVTDKSLecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGE
...   . .   ....|. .|.. ....    .  ||..|. .| ||..| .. |.|.|.....  |  . || |.|||||.|||.|.. .|.  ... .
kvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
 .|..||.||.|.|. | ..||| .|.||. ..|.
eeevdvlqivkelRkqRpgmvqsleqYiflykail

0043336 (Phosphotyrosine protein) phosphatases II 130-374 4.9e-65 215.1 In-house 34-274 (278) alignment
Range on Protein: 130-374
Range on HMM: 34-274/278.0
ApSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
   |.     ... .|.|| |||. | .||.|.. . |  .|.|.|....... . ..| .|||...||||||.||. .. . .||... .|.| .|| .
l.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaq

YIPsedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSLEcpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRT
| |   . | ..| ...| .....  ..|. .  .|.. . .. .   . | |||.|.| ||..| .  ..|..|||.|.   ...|| ..|||||.|||
Ywp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRT

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
.|.|....  ...   |.......|.|.|..| .|||.  |..|  ....
GtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0045098 (Phosphotyrosine protein) phosphatases II 116-374 6.2e-65 214.7 In-house 7-269 (278) alignment
Range on Protein: 116-374
Range on HMM: 7-269/278.0
LDCKKLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVlqnrppdnDFIHANWMTMPdKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICD
||..  .  ...|  ||..    . .. .|.||.|||. | .||.        |.|.|...... ....| .|||...||.|||.|.. .. ...||...
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmlte

WEEDGIQKCSRYIPSedNISHVCGIYRITKIDQMTMvyADVALQSFEISV-TDKSLECPSLVVKHYHFLKWRDHTAPMTS--ISVLKLLKALRDPK----
 .|.| .|| .| |.  . | ..| ...| .. ...   |. |  ...   | .  ...|. |.|.|.| | ||..| ..   |.|.||. .|.      
lvelgrekcaqywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------RPGPPVIHCSAGIGRTATLIGVDYGNQRIgEvGEMNVLDIVREMRQMRDK-AVQSHHQFIFMLMCIA
           ..|| ..|||||.|||.||.....  ... | | ...|..|.|.|..|   |||. .|..|. ....
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefll

0042113 (Phosphotyrosine protein) phosphatases II 140-374 1.8e-61 203.0 In-house 7-240 (245) alignment
Range on Protein: 140-374
Range on HMM: 7-240/245.0
KKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSedNISH
... .|.||.|||. | |||.|.. ..|  .|.|.|....... . ..| .|||...||||||.|.. ..  ..||... ||.| .|| .| |.  . | 
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesl

VCGIYRITKIDQMTmvYADVALQSFEISVTdksLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD---PKRPGPPVIHCSAGIGRTATLIGVDYG
..| ...| .. ..  ..|. .  .|.. .    . .|. | |||.| | ||..| .. ..|..|...|.    ...|| ..|||||.|||.|.|.... 
tygdftvtllseeh..lddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

NQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
 ... . ..... ..|.|.|..| .|||. .|..|. ....
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

0040439 (Phosphotyrosine protein) phosphatases II 133-374 6.2e-61 201.5 In-house 2-243 (249) alignment
Range on Protein: 133-374
Range on HMM: 2-243/249.0
TCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
..    .... .|.||.|||..| .||.|.  |   ..|.|.|....... | |.| .|||...||||||.|.. ..  ..||... .| | .|| .| |
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTdksLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGRTA
.  . | ..| ...| .. ..  ..|. .  .|.. .    . .|. |.|.....| || .| .  ..|....|.|.      ..|| ..|||||.|||.
l..ggsleygdftvtllsvev..kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
|.|. ..  ... . ........|...|..| .|||. .|..| .....
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 119-385 1.1e-57 190.2 In-house 12-278 (285) alignment
Range on Protein: 119-385
Range on HMM: 12-278/285.0
KKLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDW
 || .| .    |  |   . .   .  || |. | . |||||.|.  | |.|||.|| || |    ||..|||. .|. |||||.| ||   |.|.|  
sklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctl

EEDGIQKCSRYIPSEDNISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSLECPsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PKRpGPPV
 | |..||. | | .       | | ||  .      |   |... .  |. .   | | ..| .   | |. ||  .  ...| | ..   ||   | .
feggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedassep.lymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpic

IHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGVPQN
.|||||.|||||..|.||   || |  ....|||||||| || .||||| ||.|. . . . .. .|| . 
vhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvver

0037934 (Phosphotyrosine protein) phosphatases II 139-374 1.2e-57 190.6 In-house 7-239 (243) alignment
Range on Protein: 139-374
Range on HMM: 7-239/243.0
MKKHSEKCRYYDILCPDATRVVLqnrpPDNDFIHANWMTMPDkfRYISAQGPMDQTVED----FWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPseDNI
.. . .|.||.|||. | .||.|    ...|.|.||......  |.|  |||...||||    ||.|.. ..  ..||.....| | .|| .| |  ...
lpenlsknrysdilpydhsrvkl....egsdyinanliyvtp..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev

shVCGIYRITKIDQMTmvYADvaLQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD----------PKRPGPPVIHCSAGIGRT
  ..| ...| .....  ..|     ...... ..|. ... | |||.| | ||..| .  ..|..|...|.           .. || ..|||||.|||
..tygdftvtllseeh..ldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

ATLIGVDYGNQRIgevgEMNVLDIVREMRQMRDK-AVQSHHQFIFMLMCIA
.|||  ..  ...    .......|...|..|   |||. .|..|  ....
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_PTPRD_pd Subfamily PTPRD 132-430 8.7e-54 178.1 In-house 38-325 (564) alignment
Range on Protein: 132-430
Range on HMM: 38-325/564.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYI
.|. | ...   .| || .|.  |..||||.. .  .. |.| |...     .  || .|||. .|.|||| ||. ..   .||.   || | .||..| 
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

PSEdNiSHVCGIYRITKIDQMTMvyADVALQSFEIsVTDKSLECpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTAT
|.. . .  .| . .|  .. ..  ||. . .|..  . || |     |...|| .| || .| .  |.|.|..  |.   .  || |.|||||.||| |
Pek.g.tetygeltVtleeeeel..adyeirtfkl.kkkksses..reVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIadrmvLDGVPQNDNMLDLADFYTEFMKkvLMERKKKdeAEKAKKEKEEKRKRD
 | .|.  .|| | . ...  .|...|. |.  ||...|.||.   |     |. .   .. ..  .......|  |.| ...   | .. |.| .|   
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai.....lealacgntevesenlkqhlqk..Laeveed..temtgleleFqrLat

EAND
  ..
akei

subfamily_PTPRB_pd Subfamily PTPRB 131-377 1.3e-51 170.4 In-house 40-285 (293) alignment
Range on Protein: 131-377
Range on HMM: 40-285/293.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
  ...|.. .. ..| || .||  |..|| |   .  ...|.| ||..     .  .|..|||. .||.|||.||. .|. ..||. .  | | .|| .|
dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeY

IPSEDNiSHVCGIYRITKIdqMTMVYADVALQSFEISVtdkslECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGR
 |.... ... |  ..| .  .. .. | ......|.      |  .  |..|||. | ||  | .. ..|......|. .    . .| |.|||||.||
WPadee.pvlyGdikvtlv..aeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGR

TATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
| |.| .|   |.| |   .... || |.|. |   ||. .|.||.  |. | .
tGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_PTPN12_pd Subfamily PTPN12 137-376 1.1e-50 167.1 In-house 35-276 (290) alignment
Range on Protein: 137-376
Range on HMM: 35-276/290.0
DTMKKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN
 . ... .| || |||  | .||.|..   .  .|.| ||..  .. | .||.||||. .|..|||.|..  .   |||.|   | | .|| || |.| .
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

ISHVCGIYRITKIDQMTmVYADVALQSFEISVTdksleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTATLIGVD
 .   | ...|.... . |  |  ...... .        | .|. .|. .| ||  | .  |.|.|....|.   .   | |.|||||.||| |.| .|
eelefgefevtleeeka.vdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

YGNQRIGE--V-GEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
|  . . .  .  |..| |.|.|.|. |  .||.. |. .. ...|. 
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_PTPN13_pd Subfamily PTPN13 120-371 2e-48 160.0 In-house 15-263 (273) alignment
Range on Protein: 120-371
Range on HMM: 15-263/273.0
KLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPdndFIHANWMTMP---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDW
. ....  |..  ||     |.. .| || ..|  |.||| |..  .   .| |... .|   |...|| .|||. .||.||| ||.  ||  ..|.   
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

EEDGIQKCSRYIPSEDNIShVCgIYRITKIDQMTMVYADVaLQSFEISVTDKSLeCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR-PGPPVI
 |.|  || || |.. | . .  ..   ..... ..  |  ..  .. |.|.     |  | | .| || ||  | .. ..|.... .|  ..  || |.
kekgkvkchrywPesknkk.lk.vsnrlevellkvqkldg.fvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivv

HCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLM
||||||||. ||| .|   . |    |..| .|||..|. |.  ||.. |.||.  
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk

subfamily_PTPN9_pd Subfamily PTPN9 113-373 4.7e-48 158.7 In-house 10-286 (297) alignment
Range on Protein: 113-373
Range on HMM: 10-286/297.0
VDELDCKKLMRDFVALRAPS---TCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEK
| | . . |.......|. .   |  |  ..  .|| || |.|| | |||||.... |   |.|.||..     |  .|..|||...||.||| ||. ..
vkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

APAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD
.  .||.   .| |  ||..| |.|.. |.  | ........ .  . |   ...||. ....    |  | |. || | |.  | .. |.|..|.. |.
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee..eedykvrvleiknvkte...esrkvthfqflsWPdyGvPssaaslldvlekvre

P--------------KRPGPP-VIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
               .  ||| |.||||||||| |.| .|.  .|. ||| ..| . |. .|. |  ..|  .|. |  ...
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-373 6.2e-48 158.2 In-house 4-264 (274) alignment
Range on Protein: 118-373
Range on HMM: 4-264/274.0
CKKLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPDN---DFIHANWMTMPDKF--RYISAQGPMDQTVEDFWHMVYTEKAPAVVM
 |.| ..|. | .  .    .. ....| || .||  . .||.|... ...   ..| ||..  .|.    |...|||. .||.|||.|.|.|... .||
fkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

ICDWEEDGIQKCSRYIPSEDNIsHVCGIYRITKIDQMTMVY-ADVALQSFEISVTDKSLEcpslvVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK---
. . .|   |||..| | . .. .. . |   .|    .|   |  .... .. . .. .     |||| . .| || .|    ..|.|..  .. .   
ltklkeaneqkCavyfPdaedy.eiserygdveikvekiverndysvrklvlkylerers.....vkhywytdWPdhksPddantlldlvleveesreee

--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
  . .| |.|||||||||   |... . ... | . ..|| || ..|. |   ||...|. ..   .
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral

subfamily_PTPN3_pd Subfamily PTPN3 139-374 7.3e-48 157.9 In-house 38-272 (280) alignment
Range on Protein: 139-374
Range on HMM: 38-272/280.0
MKKHSEKCRYYDILCPDATRVVLQNRPPdnDFIHANWMTMP--D---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN
. .  .| || |||  ||||| |.. .   |.| ||.. |         |||..|||...|..|||.||. .|.  .||. .  |.| .|| .| |....
kpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPeted

ISHVCgIYRITKIDQmtmvYADVALQSFEISVTDKSLEcPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVD
 ..    ....   .     .. .    |. ..||. .  .  . .  .| | ||. |  | ..|.... .|. .  .  | |.|||||||||  || ..
eleyg.efsvkceke....detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

YGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
   . | .  ....|||||.||. |   ||...|. |.  .| 
talalieaaepvypldivrtmrdqramlvqtasqykfvCeail

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 125-377 1.1e-47 157.5 In-house 21-276 (281) alignment
Range on Protein: 125-377
Range on HMM: 21-276/281.0
FVALRA---PSTCVADTMKKHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEE
. .|.|    .| .| . ..  .| || .|   |||||..  ...  ..|.| ||..  . .. .|| .|||. .....||.||. .|. |.||.    |
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie

DGIQKCSRYIPsEDNISHVCGIYRITKIDQMTMvyADVALQSFEIsvtdKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKAL---RDPKRPGPPVI
 |  || || | .|| .   | ...... . .   |  . . |..    .  ....  |.. ....| || .| |.  .|.  |..   ...|.  | ||
agklkChrYWP.ddnselkygdvtvkstaeeek..atyierkfkl....eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGIGRTATLIGVDYGNQRI-GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
|||||.||| | |..|   ...  |  |..| ..|.|.|. |   ||.  |. |.   . | .
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 143-375 4.9e-47 155.0 In-house 57-281 (290) alignment
Range on Protein: 143-375
Range on HMM: 57-281/290.0
SEKCRYYDILCPDATRVVLQNRpPDNDFIHANWMTMpDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYR
 .| || |. | | |||.|..   | |..|||..    |  .| .||.. .|| |.| ||  ||. |.||.|.  |||  ||..| | ..      | . 
fkknrykdvvcndktrvilkdG.ydGdyvhanyvkG.lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

ITKIDQMTmvyADVALQSFEISVTDKSlECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRdpKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGE
..   . .    |  ..   .|| ||  .  . ..||..   | |.. .......|..|..||  | .|| |.||||||||| |.. .. | | . .  |
vlcseedd...kdaniikktlsvrdkd.sGkehklkhlkikswpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGke

MNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
...||.|| .|. | ..||   |.. ..  . |
ldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_PTPRA_pd Subfamily PTPRA 117-376 1e-46 154.4 In-house 30-294 (330) alignment
Range on Protein: 117-376
Range on HMM: 30-294/330.0
DCKKLMRDFVALRA---PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNR--PPDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAV
|.|..  .| || |    .|. . . ..  || |. .||  | .||.|...   .. |.| | ..    .| ..|.|||| ..|||||| |..  |. ..
dnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati

VMICDWEEDGIQKCSRYIPSEDNISHvcGIYRITkIDQMTmVYADVALQSFEIS-VTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALR--DP
||. . .|   .|| .| |.|  ...  |  |.. ....| |  |.... | .  ..|.. | .| .|. .||  | |   |...| .|||||...  ..
vmltelkerkeekcaqywPdeGlvty..Gnirve.vedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

KRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.  || |.|||||.||| |.| .|   .|.   . ..| ..|...|. | . ||.  |. |.   . . 
qsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 119-373 1.8e-46 153.7 In-house 23-279 (319) alignment
Range on Protein: 119-373
Range on HMM: 23-279/319.0
KKLMRDFVALRAPSTCVAD--TMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMI
..| ..|  |. ...   |  .... ..| || .||  | |||||.. .  .. |.| |...    .. ..|..|.|...|.|||| ||. |..  |||.
tllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

CDWEEDGIQKCSRYIPSEDNisHVCGIYRITKIDQMTMvyADVALQSFEISVTDKSLECpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRP---
..  | .  |...| |.|.   .. | . .|  ..  .  .|.  . ...      .|.    |||.....| ||  | .. |.|.||| .|  ..    
tklveklkvklkkywpeenf..eeyGrlivtleeeeel..edyiirklklnkkssevet..RevkhfqyteWpdhdvPekatslldllkrirksrektqs

GPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
|| |.|||||.||| | | .|   .|. | | ..|  .|...|  |.  || ..|..|.   .
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeal

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 132-381 8.9e-46 151.2 In-house 38-283 (288) alignment
Range on Protein: 132-381
Range on HMM: 38-283/288.0
STCVADTmKKHSEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYI
|....    .  .| || .||  | .|| |..    ...|.| |...   . | .||..|||. .||.|||..|| .|.  .||. .  |.| .|| .| 
svtagrl.avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYW

PSEDNIsHVCGIYRITKIDQMTMvyADVALQSFEISvtdksLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PKRPGPPVIHCSAGIGRTAT
|..|.  .  |   .| ... ..   |. |.....       .   | ...|..| | ||  |  .  .|.||. .    ..  || ..|||||.||| |
Pdadkp.knyGsvtvtlveskel..edfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDG
 | .|   ... |   ..|...| ..|. |   ||  .|..|.  .... .  ||
FialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 137-378 1.1e-45 151.2 In-house 41-281 (318) alignment
Range on Protein: 137-378
Range on HMM: 41-281/318.0
DTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN
 . .    | || .||  | ||| ||..   .. |.| ||..     |  ||.||.|. .|.|||| ||.  ..  .||. . || | .|. || ||.. 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

ISHvcGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD---PKRPGPPVIHCSAGIGRTATLIGV
.|.  |  ...  ....  ..|  |..|... |...    | .|. ||. .| |.  |  . |.|.|..  .    ..  || |.|||||.||| . | |
rsy..gklvvelkeeve..lsdyvlrefkvtrteee...esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiav

DYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
|   .|| . . ..|...|...|. |.  || ..|..|.   . . . 
dillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_PTPN6_pd Subfamily PTPN6 141-374 2.7e-45 149.7 In-house 53-294 (306) alignment
Range on Protein: 141-374
Range on HMM: 53-294/306.0
KHSEKCRYYDILCPDATRVVL-QNRPPDNDFIHANWMT---MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
.  || ||  ||  | |||.| ..  |..|.| || ..      . .||..|| ...||.|||.||. |..  .||.    | | .||.|| |.| . ..
enkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

vCGIYRITKIDQMTMvyADVALQSFEISVTDKSLECPSlvVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK------RPGPPVIHCSAGIGRTATLIGV
  | ...|.... ..  ||  | .. .| ..|. |. .  | .||| .| ||  |     ||..|. ..  .      ..|| |.||||||||| |.| .
.yGkisvtnvseksl..adYilRelsvskkkkkkeere..vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DYGNQRIGEVG---EMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
|   . | . |   .... ..|. .|. |   || ..|. |. . |.
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik

subfamily_Ptp69D_pd Subfamily Ptp69D 104-378 3.5e-45 149.4 In-house 16-287 (307) alignment
Range on Protein: 104-378
Range on HMM: 16-287/307.0
KKKFCNWFFVDelDCKKLMRDfvalRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWH
.|.  .. ..   . .|| .       . ....   |    | || ||   | |||.|.. .   | |.| |...    .|...| ||.|...|..||| 
rkrdtdfglak..eyekLear....eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWR

MVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVcGIYrITKIDQmtMVYADVALQSFEISVTDKSL--ECPSLVVKHYHFLKWRDHTAPMTSISVL
|.   .   .||. . .|   .||..| | ||.. .   |  .. ...      | . .....| ....   .  |  |  ||.. |.| ..| .. ..|
miaeqevtlivmlsnlteknrkkcakYWpiedevqyg.dil.vklvse..ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

KLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
||.. .|. .    .| |.||||| ||..... .|   |.. .  .... ..|...|. |.  ||| .|..|.   ..| . 
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPRG_pd Subfamily PTPRG 134-374 8.3e-45 148.0 In-house 39-284 (563) alignment
Range on Protein: 134-374
Range on HMM: 39-284/563.0
CVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DN-DFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
. .   ..  .| || .|.  | .|| |.. |   .. |.| ||..    |   .| .|||. .|..|||.|.. ...  .||| . .|.| .|| .| |
aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWP

SeDNiSHVCGIYRITKIDQMTMVYADVA-LQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRP--GPPVIHCSAGIGRTAT
. |. |  .|  ..| |.. ....  |  |.  .. . .|.     ..|..||. || ||..|  |. ||.  |     ..   || |.|||||.||| |
k.de.setygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
.| .|   ..| .   .||..... .| .|.  ||.. |.||.   . 
yivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 141-373 1.5e-44 147.0 In-house 19-260 (270) alignment
Range on Protein: 141-373
Range on HMM: 19-260/270.0
KHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT--MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
....  || |||   ||||.|..    .   .| ||..     .| .||.|.||.. |...|| |...||..|.||. . ||.| .||.|| |.| . . 
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

VCgiyRITKIDQMTMV-YADVALQSFEISVTDKSLEcPSLVvkHYHFLKWRDHTAPMTSI------SVLKLLKALR----DPKRPGPPVIHCSAGIGRTA
 .   .  ||  ...    .      .. ...|. |   ||  |... .| ||..| ..       ..||.|.|.|    . .. .| ..|||||.||| 
kl...edgkikvlalseekeegyiltrlrleekgee.rrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
||| .|.. . . | ....|| |..|.|. | . ||  .|. |.   .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykav

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 131-373 1.2e-43 144.4 In-house 35-279 (305) alignment
Range on Protein: 131-373
Range on HMM: 35-279/305.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPDN--DFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
....  .. ... .| |. .|   |  |. |.... ..  |.| |...     | .|| ||||...||.|||.... ||   .||...  |.| .|| .|
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

IPSEDNISHVCGIYRITKidQMTMVYADVALQSFEISVTDKslECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPG---PPVIHCSAGIGRT
 | . . ..  | . ..   . .  ..|     ..||. |.  .  | .| .|.. .| ||  | .. |.|.|.| ..  .. .   | ..|||||.|||
Wpesktekkefgefsvel..ksektasdyieRklkisiede..dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRt

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
 . | ||   .|. . ....| ......|. | |.||.  |. |.   .
GvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 140-373 1.6e-43 143.7 In-house 45-274 (287) alignment
Range on Protein: 140-373
Range on HMM: 45-274/287.0
KKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNisHVC
..  .| |. .|| ||  ||.|...  ..|.| | ..    .| ..| |..|| .|. .||...  .. .|.||.|. .|.  ..| .| |.|..   | 
sqnkdknRltqilvpdnyrvllkge..hpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvl

GIYRITKIDQMtmVYADVALQSFEISVTDKslECPSLVVKHYHFLKWRDHT-APMTSISVLKLLKALRDPKRP--GPPVIHCSAGIGRTATLIGVDYGNQ
| |.|. ...   |.|..  . .|.  ..|  . . . || |.. .| ..   .    ..| . .  .  ...  .. |.|||...||.|... .. . .
Geyniellnee..vnagyierklevknknk..agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin

RIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
.  . | ..|.......|. . ..||  .|..|.   .
kckteGviDvfqvlksqriqkpgsvqtveqykfindiv

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 131-370 3.5e-43 142.5 In-house 35-276 (290) alignment
Range on Protein: 131-370
Range on HMM: 35-276/290.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD----NDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCS
. |   .. .. ... |. .|. .|  |..|.. . .    |..|.| ..    .| .|| .|||. .|. |||.... || ...||...  |.| .|| 
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCq

RYIPSEDNIShvCGIYRITKIDQMTMVyaDVALQSFEISVTDKSleCPSLVVKHYHFLKWRDHT---APMTSISVLKLLKALRDPKRPGPPVIHCSAGIG
 | |..|. .   | ..|. ....|.   .   . .|.  ....   ..  |..|..  | ..    .| |...|..     .  .  .. |.|||...|
qYWpdsdtka..ygefsikllneetln..eyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvg

RTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
|.|... .. . ..    | ..|.......|. . . ||. .|. .. 
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 124-370 8.1e-43 141.6 In-house 21-270 (307) alignment
Range on Protein: 124-370
Range on HMM: 21-270/307.0
DF--VALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDG
.|  .| ..| .  .....  ..| || |. | | .|.|..      |.||||.. .  |  ..| ||||...|. .|| |.  ||  .|.|.|.  | .
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviela

IQKCSRYIPSEDNISHVCGIYRITkIDQMTMVYADVALQSFEISVTDKSLE--CPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRpgPPVIHCS
  || .| | |.    | |    | |    .    .| .   | ||.  ..    |  ..|. . .| |. .| . .. . ||.| |  .   | |.|||
kikceqywpleegqklvfgeapnt.isvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn..pvvvhcs

AGIGRTATLIGVDYGNQR-IGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
||.||. |.... .  .. |  .  ... ..|.|.|. |. |.|.  |.... 
aGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 127-374 1e-42 141.5 In-house 42-287 (298) alignment
Range on Protein: 127-374
Range on HMM: 42-287/298.0
ALRAPSTCVADTmKKHSEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQK
 ... .. || . ..  .| || ||.  | .||||..     . |.| | ..    ..  .| .|.|. .||||||.||  |.. ..||. . || .  |
eieeeekevark.penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CSRYIPSEDNISHvcGIYRITKidQMTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALR-DPKRPG--PPVIHCSAG
...| |.| .  .  |  ...   . . ..||.. . ...| ....    .  |.. || .| |...| .. |||.||.  |  ... |  | ...||||
yhkywPdegkety..geitvsl..lskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaG

IGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
.||. | | .|   .|. .   . |...|. .|. | .|||...|..|. . . 
vgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl

subfamily_PTPRK_pd Subfamily PTPRK 140-373 3.1e-42 139.5 In-house 41-273 (314) alignment
Range on Protein: 140-373
Range on HMM: 41-273/314.0
KKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNIsh
... || |. ||| .| .||.|.    |  .|.| |...        .| .|||...||.||| .|| |.. ..||. .  | |  ||..| | . ..  
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..

vCGIYRITKIDqmTMVYADVALQSFEISVTDKSLECpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALR--DPKRPGPPVIHCSAGIGRTATLIGVDYGN
  |  ... ..  | . |..  . | .. . .. |    .|....||.| ||  |.   ..|||.. .   .... |. |.||||| ||| | | .|   
.ygdikvelve..tellaelvvrifrveklargqee.irevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

QRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
. | . | ..|  .|...|. .   |. . |..|.   |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 141-376 7.8e-42 138.2 In-house 8-241 (250) alignment
Range on Protein: 141-376
Range on HMM: 8-241/250.0
KHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQkCSRYIPSEDniSHV
.  || || ||.  | .||||..     . |.| | ..   | .  .| .|||. .|.|||| ||. ||. ..||. . .| . . ...|.| |   .. 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aek

CGIYRITKIDqmTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR---PGPPVIHCSAGIGRTATLIGVDYGN
 |  ...  .  . ..||.  . . .| . |.    . .|...||. | | . | .  .||.||| ..  ..    .| ...||||.||. . | .|   
yGdvtvslls..keefadytkrklklskakka...derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

QRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.|. .   ..| .... .|. | .||.|..|..|. . |   
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 141-373 3.7e-41 135.8 In-house 47-283 (305) alignment
Range on Protein: 141-373
Range on HMM: 47-283/305.0
KHSEKCRYYDILCPDATRVVLQNRPPdNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN--ISHV
....| || |. | |  || |..  |  ..||||... |    |.| .| |...|  |||.| . .|  |. |.|.  | | .||. |..|.|.  ..  
qeagknrykdvgcldnnrvklegpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

CGIYRITKIDQMTMVYADVALQSFEISVTDKSLECP---SLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKrpGPPVIHCSAGIGRTATLIGVDYGN
 .  .|.   . .  .  ..  . ... |   .| |   .. |.|||.  | |   | . ...|.||.  |  |  || |.||||||||| ... ..|  
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..gpivvhcsagigrtgsvvmleyil

QRIGEVGEM-NVLDIVREMRQMRDKAVQSHHQFIFMLMCI
... .   . .   |.. .|. |....|. .|..|.   |
dqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi

subfamily_PTPN1_pd Subfamily PTPN1 138-375 5.7e-41 135.1 In-house 28-269 (290) alignment
Range on Protein: 138-375
Range on HMM: 28-269/290.0
TMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
 ...  .. || |.   | .|..|..   |||.| |. . ... | .|| .|||. .||. ||.||. .|. ||||.    | . .|| .| |.... . 
klpenrnlnryrdvspydhsriklera..dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeeke

-VCG--IYRITKIDQMTMVYADVALQSFEISVTDKslecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP----KRPGPPVIHCSAGIGRTATLIG
 ..    .... | . .  |  | |  .|   |..     . .. |.|...| | . | .  . ||.|  .|.     .  ||.||||||||||. |.. 
llledtklkvkliseerksyytvrllelenlktqe.....treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

VDYGNQRIGEVGEM---NVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
||    .| . ...   .. . . |.|..|   .|   |. |  . | .
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 136-377 1.1e-39 131.3 In-house 42-284 (297) alignment
Range on Protein: 136-377
Range on HMM: 42-284/297.0
ADTMKK---HSEKCRYYDILCPDATRVVLQ--NRPPDNDFIHANWMTMpDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIqKCSRYIPS
..|. .     || || .||  |  || |.  |  || |.. | ..    | |.|. | ||..||.||| ||. |.. ..||. | .|    || || . 
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg.nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

EDNIShvCGIYRITkiDQMtmVYADVALQSFEISVTDKSLEcPSLVVKHYHFLKWRDHTAPM--TSISVLKLLKALRDP---KRPGPPVIHCSAGIGRTA
.   .   |   ..   .   |         |..||  .      ||| |.|..| |.. .   .  |.|||.. .|.    .  || ..||.||.|||.
kgvtt..fGdvsvv..lls..vsereGfikrelevtkgkak.arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
 |. .|    .. .  |......|. .|| | . || . |. |.   . . .
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 142-376 1.1e-39 130.9 In-house 50-280 (301) alignment
Range on Protein: 142-376
Range on HMM: 50-280/301.0
HSEKCRYYDILCPDATRV-VLQNrpPDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCG
. .| ||  . |   | | |...       |||||.  . .  |.|..|||...| |||| |.   .   .||..   |. ..||. |.|.. . .   |
pkdkhryptvPckPstavevivd..GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

IYRITKIDQMTMVYADVALQSfeISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPgpPVIHCSAGIGRTATLIGVDYGNQRIGE
 ..|.  .. ...  ..  ..  . |.| . . ..  | || . .| |.  | . . . .|.. ... ..|   |.||||||||. ..|| .|  ...  
rfkikiknkelilnkkiskrt..levedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekP..ivvhcsaGiGrsvafigteylarevea

VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
  .... . ....|. | ..|| ..|. .| .    |
dptieltealkhlrehrwngvqtnsqlywmtlGtvyr

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 99-399 1.6e-39 131.1 In-house 21-311 (319) alignment
Range on Protein: 99-399
Range on HMM: 21-311/319.0
QELANKKKFCNWFFVDELDCKKLMRDFVALrapSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTV
|.|.||..| .     | . ... .  | |   ..     ...  .| |. .||  | ..| |..       |.| | ..|    | .||.||||.| |.
qqlsnksdfdddltklevefrracklgvnl...adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntl

EDFWHMVYTEKAPAVVMICdweedgIQKCSRYIPSEDNISHVCGIYRITKIDQMTMvyadVALQSFEISVTDKSLECPSlvVKHYHFLKWRDHTAPMTSI
.||| |..  .. ..|..        .|||.| | . .| .  .  ... ...        .....|.|   |  .  .  .. .||| | |.  |  ..
adfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirk..itqfhflGwpdvGvpdyps

SVLKLLKALR----DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGvpQNDNMLDL
 ...|.| .|      . . . |.|||||.||| . | .|   .|. |   ..| ..||..|| |.. ||.  |. |. . . .  ..     .  | |.
dlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh..sdvampdf

ADFYTEFM
  .. |  
payleels

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 143-370 3.9e-39 129.1 In-house 56-282 (305) alignment
Range on Protein: 143-370
Range on HMM: 56-282/305.0
SEKCRYYDILCPDATRVVLqNRPPDNDFIHANWMTMP---DKfRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSED-NISHVC
  | || |. | | . | | ..|.  |.||||..  |   .| |.| ||||.|||...|| ||  .|   .||.|   | |  ||..| |    .  .. 
itknryqdvpcqdqsavkl.dkpspsdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

GIYRITKIDQMTMVYADVALQSFEISVTDKSleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRpgPPVIHCSAGIGRTATLIGVDYGNQRIG
.   . ..     .  |  .|   . .|       .. |.| .. .| |   |   .. |.|| |.|  |   | |.||||||||| |.. ..|  ..| 
sgivvenvsgskpmerdaeiqitllnltysg..dqkmsvrhlqwtewpdrgvppckltslellsairgskv..pivvhcsagigrtgtivaieyilekia

EVGEMN-VLDIVREMRQMRDKAVQSHHQFIFML
|  .   . ..|. .|. |  ..|.  |..|. 
enkpcppmpelvkalrdqrafsiqndvqylfih

0041856 (Phosphotyrosine protein) phosphatases II 144-378 4e-39 129.4 In-house 3-172 (182) alignment
Range on Protein: 144-378
Range on HMM: 3-172/182.0
EKCRYYDILCPDATRvvlqnrppDNDFIHANWMTMPDKF-RYISAQGPMDQTVEDFWHMVYTEKAPAVVMICdweedgiqkCSRYIPsednishvcgiyr
.| ||.|||..| .|        |.|.|.||.. .. .. |.| .|||...||.||..|.. ..  ..|...         . .| |             
dknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

itkidqmtmvyadvalqsfeisvtdkslECPSLVVKHYHFLKWRDHTAPMtSISVLKLLKALRDpkRPGPPVIHCSAGIGRTATLIGVDYGNQRigevgE
                            |     . .|..| | ||..|    ..|..... ..  ..|| ..|||||.|||.||.. ..  ..     .
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

MNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
... ..|...|..| ..|.. .|..|  ... ... 
vsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 139-399 8.2e-39 128.8 In-house 22-275 (284) alignment
Range on Protein: 139-399
Range on HMM: 22-275/284.0
MKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICdweedgIQKCSRYIPSEDNIS
...  .| |. .||  | ..| |..       |.| | ..|    | .||..|||.| |..||| |..  .. ..|..        .|||.| | . .| 
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

HVCGIYRITKIDQMTMvyadVALQSFEISVTDKSLECPSlvVKHYHFLKWRDHTAPMTSISVLKLLKALR----DPKRPGPPVIHCSAGIGRTATLIGVD
.  .  ... ...        .....|.|   |  .  .  .. .||| | |.  |  .. ...|.| .|      . . . |.|||||.||| . | .|
eerfkvkvdsveesee....yvvrdielsedgkekdirk..irqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

YGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGvpQNDNMLDLADFYTEFM
   .|. |   ..| ..||..|| |.. ||.  |. |. . . .  ..     .  . |.. .. |  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh..sdvalpdfpayleels

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 140-377 1.8e-38 127.2 In-house 42-277 (315) alignment
Range on Protein: 140-377
Range on HMM: 42-277/315.0
KKHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
.   .| || .||  | .||.|   .  ||.|.| |  .   |.   ||..||| . .|.|||.||. ||. ..||. . .|.   || .| | ..  | 
tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

VCGIYRITKIDQMTMvyADVALQSFeisVTDKSLEcpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGN
  | .... ..  .   .|   . .   || || |  |  |  ..| .| |. ..  . |.|||.|...  .  .  . ..|||||.|||  .| .|   
efGsikvellslead..tdgvarkl...vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

QRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
..| .   ..|...|...|. | . ||.. .. |.   . . .
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 143-376 2e-37 123.5 In-house 44-275 (515) alignment
Range on Protein: 143-376
Range on HMM: 44-275/515.0
SEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCG
 .| || .||  | .|| |   |  |..|.. |  .   |    ||..||| . .|.|||..|. |.  ...|. . .|.   ||..| |     |   |
fkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

IYRITKIDQMtmVYADVALQSFEISVTDKslecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTATLIGVDYGNQRI
 ...  .       ..   . ...   |.     |  |  .|| .| |. .|  . |.|||.|...    .   | .||||||.|||  .| .|    ..
sikvelvsle..actggikrkltvlkgdd.....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
 .   ..|...|. .|| | . || . |. |.   . . 
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 134-374 3.9e-37 122.4 In-house 29-266 (281) alignment
Range on Protein: 134-374
Range on HMM: 29-266/281.0
CVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD---NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
| .       .| || .| | | .|| |. . |.    |.||||..  |  |  || .|||  .|  |||.|.. |.. |.||.|.. |   .||. |.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

SEdniSHVCgiyriTKIDQMTMVYADVALQ-SFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDpkRPGPPVIHCSAGIGRTATLI
 .   .|.|      ..|.... | | ... |.  .  . | |  . .. |. . .| |   | .|  .||.|. .|   |  |||||||||.||. ||.
rn...ahcc.....lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira..rstppvihcsagvgrsgtlm

GVDYGNQRIGEV-GEMNVLDIVREMRQM-RDKAVQSHHQFIFMLMCIA
 |.   | |       .. .||  .|   |  .||. .|....   . 
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 132-370 4.3e-37 122.5 In-house 23-259 (283) alignment
Range on Protein: 132-370
Range on HMM: 23-259/283.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPdnDFIHANWMT----MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
  .. .. ... .| |. .|.  |  || |.. ..  |.| | ...      .. .|| ||.|.|.|| |||.||. ||. |.||.    ||  .|||.|
ldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

IPSEDNISHvcGIYRITKIDQMTMvyADVALQsfEISVTDKSLECPSLVVKHYHFLKWRDH--TAPMTSISVLKLLKALRDPKRPGPPVIHCSAGIGRTA
 |..  . .  | . .|  ...|        .  |. .  .|    .|.. || .  | .    |.. |.  . ....|.  .. || |.|||.||||||
WPkrGsedy..Geftvtlrketts..nsfiik..elllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
..|..    . .     ..|  .|. ||. |  |||.  |. .. 
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 136-379 5.3e-36 119.1 In-house 37-273 (288) alignment
Range on Protein: 136-379
Range on HMM: 37-273/288.0
ADTMKKHSEKCRYYDILCPDATRVVLQnrpPDNDF-IHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdn
.|.  . . . || .. . |.||| |.    | || |.|| ..  . | | | || |.. |.| .|.|. ..    .||.|.  | | .|   | ||.  
idsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk..

ISHVCGIYRITKIDQMTMvyADVAlQSFEISVTDKSLECP--SlVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRpgPPVIHCSAGIGRTATLIGVD
. .   | |. .. .     ||.  .  ..|.   | |      .||. |.|.| |.. |   .| |.||. |.. ..  | |.|.|||.|||.||| . 
lGekarigrlctvvkkkr..adid.klvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk..PivvhssaGvGrtgtlilil

YGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVL
   . .  .  . .  .. ..|. | ||.|.  |....  |. . ..|
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 140-374 1.1e-35 117.8 In-house 36-274 (287) alignment
Range on Protein: 140-374
Range on HMM: 36-274/287.0
KKHSEKCRYYDILCPDATRVVLQNRPP-DNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdNISHV
    .| || |.|  | |||.| . .    |.| ||...   |. ..|.||||.  || ||| .|. ... .|...    |.. .|| .| |   .    
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

CGIYRITKIDQmTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSIS-------VLKLLKALRDPKRPGPPVIHCSAGIGRTATLIGV
 | | .. .|. ..   . . ... .   .      . ||| ...|.| |.... |...       | . ... || .  ||.|.|...||||. .|. .
vGGysvvlldy.dikePeygvralrlidletr...earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
    .|  ..|...|  .|  .|. |   ||.  |. ..   ..
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

subfamily_PTPN23_pd Subfamily PTPN23 139-371 3.5e-35 116.2 In-house 40-274 (288) alignment
Range on Protein: 139-371
Range on HMM: 40-274/288.0
MKKHSEKCRYYDILCPDATRVVLQnrPPDNDFIHANWMT--MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
 |..||| |. |||  | .||.|.     .|.| | ..    |    .| .|.|...|. ||| ||| .|.. .||. . || | .|..|| |.. . ..
aklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

VCGIYRITKIDQMTMVYadVALQSFEISVTDKSLecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD----P--KRPGPPVIHCSAGIGRTATLIGV
. | ...|  .. .. .  .  . ..... |..       |.| .. .| .. .| .  ..|..|.. ..       |   | |.|||||.||| ..  |
kfgdlsvtlksvretet..hvervlkletldada...vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

dYGN-QRIgEVGE--MNVLDIVREMRQMRDKAVQSHHQFIFMLM
 |.  . . |.|.  ......|. .|. |   || ..|. |.. 
.yaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsye

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 141-377 5e-35 115.9 In-house 48-279 (315) alignment
Range on Protein: 141-377
Range on HMM: 48-279/315.0
KHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdniSHV
.  .| ||..|.  | .|| |   .  |. |.. ||..     | |||.||||  ..|.||| .|. |.   .||. .  |.  .|. .| | .     .
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kvi

CGIYRITKIDQmtMVYADVALQSFeiSVTDKS--LEcpslvVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PKRPGPPVIHCSAGIGRTATLIGVDYG
 | . .|....   |. ... ...  ||. ..   |     |  .|.  | |   |  .|....| .  .    .  |. |.|||||.||| |.| .|  
yGkitvtrkse..evnteytvrtl..svvfgdnire.....vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldav

NQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
 ...     ..| .... .||.| |.||. .|. |.   . . .
ldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_PTPRN_pd Subfamily PTPRN 130-376 1.3e-34 114.2 In-house 44-291 (297) alignment
Range on Protein: 130-376
Range on HMM: 44-291/297.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM--PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCS
 |||. .   .|  .| |. ..|  | .|| |...    ..|.| |  ..   | .  ||..|||. .|| ||| ||. . .  .|...  ||.|...|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

RYIPSEDniSHVCGIYRITKIDQMtMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLL----KALRDpkRPGPPVIHCSAGI
|| | |   |.| .|| .  . .  .   |  ..|| .   ..|    .  |  .||| |.....| .. |.|..     |. |   |  | |.|||.| 
rywpdeG..sevyhiyevhlvseh.iwcddylvrsfylknlqts...etrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGa

GRTATLIGVDYGNQRIG-EVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
||| . | .|   .|.   | |...   .  .|. |.. |....|| |.|...|. 
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

0051429 (Phosphotyrosine protein) phosphatases II 167-377 1.8e-34 115.0 In-house 3-225 (272) alignment
Range on Protein: 167-377
Range on HMM: 3-225/272.0
DNDFIHANWMTMPdkFR------YISAQGPMDQTVEDFWHMvYTEKAPAVVMICDWEEDGIQKCSRYIP--------SEDNISHVCGIYRITKIDQMTMV
 .. |.|... ..  .|      .. ..||.. |..|||.. ....  ..|.... || | .||.||.|         .|.      ..... . .....
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

YADVALQSFEISVTDKSLECpsLVVKHYHFLKWRDHTAPMTSisVLKLLKALRDpkrPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMN--------
. |. |  .... . .  |   . | |.|.. | || .|  .  .|.||..|.|   .|| ..|||||..||.|.. ...  .....   ..        
lldyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
....|.|.|..| .|||. .|..| ...... .
leeaveelraqrpgavqteeqylflyeallell

0043147 (Phosphotyrosine protein) phosphatases II 166-370 5.1e-34 112.9 In-house 3-154 (172) alignment
Range on Protein: 166-370
Range on HMM: 3-154/172.0
PDNDFIHANWMTMPDKF-RYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWeedgiqkcsryipsednishvcgiyritkidqmtmvyadvalqsfeis
...|.|.|... .. .  |.|  |||.. |..|||.|.....  ..|.....                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

vtDKSLECPSLVVKHYHFLKWRDHTAPmTSISVLKLLKALRD---PKRPGPPVIHCSAGIGRTATLIGVDYGNqrigevGEMNVLDIVREMRQMRDKAVQ
   .  |. .  . .|..| | ||..| ..  .|..|. ...    .. || ..|||||.|||.||.  ..          ......|...|..| .|||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

SHHQFIFML
. .| .| .
npsqyrfly

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 127-414 1.9e-33 110.8 In-house 12-282 (290) alignment
Range on Protein: 127-414
Range on HMM: 12-282/290.0
AlrapstcvADTMKKHSEKCRYYDILCPdATRVVLQNR--PPDNDFIHANWMTMPDKFRYISAQGPMDQT-------VEDFWHMVYTEKAPAVVMICDWE
         .| .|||. . |.   |   ||||||..      .|.|||| .|.|.  | |  | |  ..       .|.|| |.  ||.  |||.|. |
k........tdyvkkhemdqRlevpLve.atrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefe

EDGIQ----KCSRYIPSEDN-ISHVCGIyRITKidqMTMV-YADVALQSFEISVTDKslecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRdpKRPG
|   .     |..|.| . . .  . |.  .       ..   ||     ..   |.      . |.|. .  | .  .. .....|.|.. ..  ..  
eksantslfaCakYvpesvgeelkfkgl.tvkC...kskekeddvetRelvvkfdde....eeftvtHsllkgWnklnvqedtktllsliqkvk..askt

PPVIHCSAGIGRTATLIGVDYGNQRIG-EVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAdrmvldgvpqndnmLDLADFYTEFMKKVLMERKKKD
| ..||  || | |.|  .. | | |    |.... |.. ..|..|..|..|.... |..  |               | . ... .|...   .. |..
pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..............llaievldqfaeeetekkakae

EAEK
| | 
eket

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 144-373 8.2e-33 108.6 In-house 5-235 (237) alignment
Range on Protein: 144-373
Range on HMM: 5-235/237.0
EKCRYYDILCPDATRVVLQNRPPDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNiSHVCGIY
 | || .| . | .||||.    . |.| |...   |    .||.||||.. . .||| ||. ||   .||.    |   .|| .| || |.     |..
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paaygvl

RITKIDQmtMVYADVALQSFEISVTDKSLECpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGRTATLIGVDYGNQRI
 ..   .    ..| ...|. .|.  .  |    ... |.|  | |.  |  . ..|.. | . .      . || .||||||.|||. .. .|   .. 
tvslkkk..eefsdytvrslllskrltlkev..rlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
 |   ... . |  . . |   .|.. |..|.   |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti

0046846 (Phosphotyrosine protein) phosphatases II 158-372 2e-32 107.8 In-house 2-168 (176) alignment
Range on Protein: 158-372
Range on HMM: 2-168/176.0
RVVLQNRPPDNDFIHANWMTMPdkfRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHvcgiyritkidqmtmvyadva
|..|   ..| |.|.||.. ..   |.|  |||. .|..||..|.. ..  |||..... | |  || .| | . . ..                     
rlrllgldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

lqsfeisvtdkslecpslvvkHYHFLKWRDHTAPMTsISVLKLLKALRDPKRPG-PPVIHCSAGIGRTATLIGVDygnqrIGEV-GEMNVLDIVREMRQM
                     .|..| |.||..|     .|.||...|.  . | | ..|||||||||.||.  .     . |    ..|.......|..
.....................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreq

RD-KAVQSHHQFIFMLMC
|  .|||. .|  |  ..
RplgavqtpeQyrflyef

0049260 (Phosphotyrosine protein) phosphatases II 181-370 2.1e-32 107.3 In-house 8-143 (152) alignment
Range on Protein: 181-370
Range on HMM: 8-143/152.0
KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIpsednishvcgiyritkidqmtmvyadvalqsfeisvtdkslecpslvvkHY
.|..| .|||...|..|||.|... .. ..||.....|.|  || .||                                                  .|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................qy

HFLKWRDHTAPMTSISVLKLLKALRD--PKRPGPPVIHCSAGIGRTATLIGVDYGNqrigevGEMNVLDIVREMRQMRDKAVQSHHQFIFML
..| | ||..|  |. .| ||....    .. || ..|||||.|||.||.  ..          ......|. .|..| .||....| .| .
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 130-379 6.3e-32 105.6 In-house 34-281 (439) alignment
Range on Protein: 130-379
Range on HMM: 34-281/439.0
APSTCVADTMKKHSE--KCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIqkc
 . .|.|  . .. .  | || |.   | |||.||. |  |   .| ||..    |.  ||..||| ..|..||| .|. .|.  .||...  |      
pdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...

srYIPSEDNISHVCGIYRitkIDQmTMVYADVALQSFEISVTDKSLECpSLVVKHYHFLKWRDHTAPMTSISVLKLLKAL---RDPKRPGPPVIHCSAGI
  | ||.... .   . |   .|.  .   . ... | .     . |     | ..|.. | |.  |  .  ||..|.|.    | .  || |.|||||.
..ywpsdaevcygdiavr...vdr.nielpnyvirgfkvfnerdttek.ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagv

GRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVL
||| |.| .|   ...    ....  ||. .|. | . ||.  |..|.  .. . .| 
GrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 131-370 1e-31 104.6 In-house 41-283 (310) alignment
Range on Protein: 131-370
Range on HMM: 41-283/310.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQ-NRPPDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYI
 |.   ...||.  | || |..| |..|| |. ..   .|.||||..     .  .| .|||...|. ||| |.. |.| .....|   |.|  ||  | 
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PSEdNISHVCGIYRITKID----QMTMVYADVALQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKllKALRDPKRPGPPVIHCSAGIGRT
||   ..   |  |.|..     .. ..   |..   .. | ..  .   | |.  .. .| |   |      .   . |    | || |.|||||..|.
psl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqvrhgpcvvhcsagkdrl

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
 ... ...  ... .  .... ... |... | . .|.. |.... 
yvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid

0049772 (Phosphotyrosine protein) phosphatases II 133-375 1.3e-31 105.9 In-house 37-278 (314) alignment
Range on Protein: 133-375
Range on HMM: 37-278/314.0
TCVADTMKKHSEKCRYYDILCPDaTRVVLQNRPP-DNDFIHANWMTMPdkFRYISAQGPMDQTVEDF----------WHMV--YTEKAPAVVM-------
|...    .. .| ||.|||. | .||.|.. |  . |.|.|...  .   ..| .|||.. ||.||          |.||  .  .   .||       
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------ICDWEEDGiqkcsryipsedNISHVCGIYRITkidqmtmvyadvalqsfeiSVTDKSLECPSLVVKHYHFlKWRDHTAPmTSISVL
              ...  . |            |. ... .  .                    ....    .. |..|....  . |..|| ..  ..
delsrLdaAlgKtpllildgng............neptaadlellk...................eelydpelferlgikylri.pvpDgsap.lledfd

KLLKALRDPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGevgeMNVLDIVREMRQMRD-----KAVQSHHQFIFMLMCIAD
..|..... ...|| ..||.||.|||.|.. ..|   . |    ... ......|..|       ....  |..|.|... .
eflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealle

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 132-409 1.9e-31 103.9 In-house 35-307 (312) alignment
Range on Protein: 132-409
Range on HMM: 35-307/312.0
STCVAdtMKKHSEKCRYYDILCPDATRVVLQNrpPDNDFIHANWMTMPDKFR-YISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPS
| | |  . |  .  || .| | |  |  |     .| .||||.. .  |   ....|||...|.  ||... .  . .....| . ||| .||..||  
secta..flkfkdlnrypniqcwdrgrftlag..denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd

EDN----ISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSLECpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPgpPVIHCSAGIGRTAT
         |       |.|.        .. . . . |     |     ..|| .  | ||  | .  . |.|| |..  |.|   . |||||.||| |
ivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes...klnhyqwaswpdhgmpdscdtalrllsavkkdkkp..viahcsagvgrtgt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGVPQNdNMLDLADFYTEFMKKVLMERKKK
|. ..     .      || |.   .|. | ..|.   |... | |. . .   |. .  |  . . |   . |    . | |
laliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykr.neqewtkfketyakikakklkik

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 139-378 9.7e-31 102.1 In-house 45-289 (325) alignment
Range on Protein: 139-378
Range on HMM: 45-289/325.0
MKKHSEKCRYYDILCPDATRVVLQNR--PPDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWeEDGIQKCSRYIPSEDNIS
  .  .| |. ...  | .||||. .   |. |.| |...    .|  ...|| |. .|..|.| .|.  ... ||..    . | ..|. | | |   |
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgks

HVCGIYRITKIDQMTMvyADVALQSFEISVTDKSlecPSLVVKHYHFLKWRD---HTAPMTSISVLKLLKALRDPKR-----PGPPVIHCSAGIGRTATL
   |  ..  .   ..  .|   . ...  ..|     .. || ...  | |   .  | | ||.|.|.||. .  .      .| ..|||||.||| ..
ktfGglevklrtieei..sdyvhrvldvkqvkkG...etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

IGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
| .    ... |  ...... |. .|. | . |..  |.|..  .... ..
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym

0036282 (Phosphotyrosine protein) phosphatases II 169-369 1.7e-30 101.4 In-house 3-162 (174) alignment
Range on Protein: 169-369
Range on HMM: 3-162/174.0
DFIHANWMTMPD--KfRYISAQGPMDqtvedFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSednishvcgiyritkidqmtmvyadvalqsfeisvt
|.|.|... .    . |.|  |||..     ||.|.. ..  .||| ....|.|. || .| |.                                    
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

dkSLECPSLVVKHYHFLKWRDHTAPMTSIsVLKLLKALRDP---KRPGPPVIHCSAGIGRTATLIGVDYGNQRIGeVGEMNVLDIVREMRQMRDKAVQSH
    | ..  . .|..| | ||..| .|| .|...|....    .. || ..|||||.|||.||.. ..  ...   . ...||.|||.|..| ..||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

HQFIFM
.|..| 
sQyrfl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 141-292 2.3e-30 100.5 In-house 30-181 (297) alignment
Range on Protein: 141-292
Range on HMM: 30-181/297.0
KHS--EKCRYYDILCPDATRVVLQNRPPDNDFIHANWMTMPD---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNIS
. |   | || |||  | ||| |.. ....|.| |.....||   ...|| ||||...||.|||..|. .   ..||..  .||| .||  | || ..  
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

HVCGIYRITKIDQMTMVYADVALqsFEISVTDKsleCPSLVVKHYHFLKWRDHTAPM
  .| . .  . ...  .  | |   |. .  .     | ||.|  || | ||  | 
lkagdvvveflsstsdefdrvil..telqliyr...sesrvvrhvqflswpdhGvps

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 143-373 2.3e-30 100.5 In-house 8-236 (239) alignment
Range on Protein: 143-373
Range on HMM: 8-236/239.0
SEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPseDNISHVC
  | || .|.  | .||||..    | .|.| |...   |     ||..|| .  .  |||.|.. |.   .||.    |   .|| .| |  |. |. |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskyc

GIyRITKidQMTMVYADVALQSFEISVTDKSLECpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPG--PPVIHCSAGIGRTATLIGVDYGNQR
 . |.|   . | |.||  ...| .|   .. |     | .|||  | |.  |  . .|| | . .     ||  | |||||||.||| ... .|   ..
nl.rvtl..rktevfadyiirtfvmsqvgqteer...yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
  .   ..... |. .|. | . ||.  |..|. ...
akkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 143-373 2.4e-30 100.4 In-house 9-237 (239) alignment
Range on Protein: 143-373
Range on HMM: 9-237/239.0
SEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPseDNISHVC
  | || .|.  | .||||..    | .|.| |...   |     ||..|| .  .  |||.|.. |.   .||.    |   .|| .| |  |. |. |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskyc

GIyRITKidQMTMVYADVALQSFEISVTDKSLECpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPG--PPVIHCSAGIGRTATLIGVDYGNQR
 . |.|   . | |.||  ...| .|   .. |     | .|||  | |.  |  . .|| | . .     ||  | |||||||.||| ... .|   ..
nl.rvtl..rktevfadyiirtfvmsqvgqteer...yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
  .   ..... |. .|. | . ||.  |..|. ...
akkqktvdifnyvkairedrphmvqtseqyvfihlav

subfamily_PTPN14_pd Subfamily PTPN14 130-372 2.7e-30 100.4 In-house 37-291 (300) alignment
Range on Protein: 130-372
Range on HMM: 37-291/300.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQ-NRPPDNDFIHANWMTMP---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCS
. ... . ....  || |. |.|  . .|| |. ..  ....| |  . ..    .  || ||||...||.|||.||. ..   .||. . |||| .|. 
edallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

RYIPSE-DNISHV-CGIYRIT-KIDQMTMVYADVALQSFEISvTDKSlecpsLVVKHYHFLKWRDHTAPMTS---ISVLKLLKALR-------DPKRPGP
.|.|.. .. ..|  | ...| |  . .  ..  .|.   .  . .        | |  .  | ||  |      .| |. ....|       ..|   |
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skee.....rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

P-VIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMC
| ..|||||.|||  || .|   . .    |...  ... .|. |.  ||.  |. |.   
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 125-376 2.3e-29 97.0 In-house 26-235 (392) alignment
Range on Protein: 125-376
Range on HMM: 26-235/392.0
FVALRAPSTCVADTMK--KHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEED
|  |  |      . .     .| || .||  |..||.|   .  ||.|.. | ..   |    ||..|||   ...|||.||. |.. ...|. . .| 
fhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkeg

GiqkcsryipsednishvcgiyritkidqmtmvyadvalqsfeisvtdKSLECPSlvVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHC
                                                |  .. .  |  .|| .| |.  |  . |.||..| ..    .   | .|||
d...............................................kgddart..vaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc

SAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
|||.|||. .| .|    .  ..  ..|...| ..|. |   ||.. |. |.  .. . 
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 194-391 5.8e-29 95.9 In-house 40-231 (255) alignment
Range on Protein: 194-391
Range on HMM: 40-231/255.0
TVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDqmtmVYADVALQSFEISVTDKSlECPSLVVKHYHFLKWRDHTAPMT
||. |....   |.  |||.||..|.|..|||.|.| | .   .     .|  .      ||| |.  ||  |          ||||..  | .. ||  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlge.kkkthtvkhysykGWieknaPel

SISVLKLLKALRDPKrpgPPVIHCSAGIGRTATLIGVDYGNQ------RIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMvldgVPQNDN
.  .|..||. || |   . |.|||.||||.|... ...  |      .  | .|.. | ...|.|..| .|..   |. | .. . | .     |... 
areilnilkvvrdsk...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv....fpkgel

MLDL
  ..
eaky

subfamily_CG7180_pd Subfamily CG7180 131-371 6.1e-29 95.6 In-house 31-284 (296) alignment
Range on Protein: 131-371
Range on HMM: 31-284/296.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEeDGIQKCSRY
  .| ..  |.  || |. ... .| .||||..     ..|.| | ..  .  |  ||  ..|...||..|| .|| |.. |||....   |  ...  |
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktf.dfakmypsy

IPSEDNISHVCGIYRITKIDQMT-MVYADVALQSF--EISVTDKSLECPSLVVKHYHFLKWRD-HTAPMTSISVLKLLKA---LRDPK----RPGPPVIH
.| . .  .   .  |.. .|.. ..   . |.     .. ..|  . .  .||.... .|   .  |. . ....|..    .|.        || |..
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLM
.| | .|.   ...|   . . . .|..| . |. .|. | . |.. ... ..  
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd

PTPc_DSPc_SM00012 277-374 8.1e-29 95.3 In-house 2-104 (105) alignment
Range on Protein: 277-374
Range on HMM: 2-104/105.0
VKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRP----GPPVIHCSAGIGRTATLIGVDYGNQRIGEV-GEMNVLDIVREMRQMRDKAVQSHHQFIFMLM
|||||...| || .| .| |.|.||.|... |.     .| |.|||||.|||.|.. .|.  |.. .  .|.....||.|.|..| ..||. .|..|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CIA
...
all

subfamily_hpo-7_pd Subfamily hpo-7 191-406 8.3e-29 95.3 In-house 43-251 (263) alignment
Range on Protein: 191-406
Range on HMM: 43-251/263.0
MDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITkidqMTMVYADVALQSFEISVTDKSlECPSLVVKHYHFLKWRDHTA
. ||.. |....   |.  |||.||..|.|..|||.| | | .   .     ..     | |  || |.. |.  | .        |||| .  | .. .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc....ttkvqsdvllktlellstlge.KkkthtvkhysykgWieknd

PMTSISVLKLLKALRDPKrpgPPVIHCSAGIGRTATLIGVDYGNQ------RIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMciadrMVLDGVPQ
|. ....|..||. |. |   . |.|||.||||.|    ..   |      .  . .|.. | ...|.|..| .|..   |. | ..     |||| | .
pelareilnilkvarnsk...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil.....mvLdfvln

NDNMLDLADFYTEFMKKVLMER
|    .|   | |  |  |  |
nfakgeleakyqeirksylhar

0051082 (Phosphotyrosine protein) phosphatases II 167-373 3e-28 93.7 In-house 2-149 (151) alignment
Range on Protein: 167-373
Range on HMM: 2-149/151.0
DNDFIHANWMTmPDkfrYISAQGPMDqtveDFWHMVYTEKAPAVVMICDWEEDGiqKCSRYIPSEDnishvcgiyritkidqmtmvyadvalqsfeisvt
 .|.|.....| .    ..  .||..    ||. ......  ..|.... || |  .| .| |...                                  
lsdyinfsyvt.gg...lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

dkslecpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDpKRPGPPVIHCSAGIGRTATLIGVDYGNQRigevgeMNVLDIVREMRQMRDKAVQSHHQF
        . |.|...| | |.. |..  .||..|..|.| |..|| ..|||||.|||.||....   ..      ... ....|.|..|  .||.. ||
........ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

IFMLMCI
.| |...
lfqlfal

0044763 (Phosphotyrosine protein) phosphatases II 155-371 3.7e-28 93.8 In-house 3-165 (178) alignment
Range on Protein: 155-371
Range on HMM: 3-165/178.0
DATRVVLQNRPP--DNDFIHANWMTmpdKFRYISAQGPmdqtvEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNishvcgiyritkidqmtmv
| |||.|.|..     |.|.|....    . |.....|     .|.. ... ..  ..|....  | | .|| .| |.| .                   
drtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...................

yadvalqsfeisvtdkslecpslvvKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTATLIGVDYGNQRigevgEMNVLDIVR
                          .|... . ||..|  .  .|........   ...|| ..|||||.||..||.  ..  ..      ... ....
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

EMRQMRDkAVQSHHQFIFMLM
..|..|  .|.. .|  ....
lvrerRp.ivpnpgqlrqLye

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 138-377 4.2e-28 92.7 In-house 33-288 (302) alignment
Range on Protein: 138-377
Range on HMM: 33-288/302.0
TMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMTMpDKFRYISAQGPMDQ-----------------TVEDFWHMVYTEKAPAVVMICDWEEDG
 ..|.  . |    .|   |  .|..   .|||| || ... |. ..| ||||||                  |.| .| ..   .   || .|.  ||.
nlekdiserrkslficepktmaklvdf..kndfinanvlkl.deikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvede

IQKCSRYIPSEDNISHVCGIYRITKIDQMTMVY--A---DVALQSFEISVtDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPgpPVI
 .||. |   . .     | | .. ..  | .   .   .. | . ||   .|  .     |.  .|  | || ||  . . |..||     |.    ..
ekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveikn.ekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn..vlv

HCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
|||||.||| ||. . || |   .    ..|.||  .|| |  |||...| |..|.|..  .
hcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl

subfamily_egg_pd Subfamily egg 140-378 4.8e-27 89.4 In-house 38-273 (307) alignment
Range on Protein: 140-378
Range on HMM: 38-273/307.0
KKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDgiQKCSRYIPSEDNISH
. . ||.|   . | | .|| |. |     .|||||| .   |    .| || |.  ||.||| ||. |. . .||.    |   ..|  | |  .. | 
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

VC--GIYRITKIDQMTMvyADVALQSFEISVTDKSleCPSLVVKHYHFlkwrDHTAPMTSISVLKLLKALRDPKRpgPPVIHCSAGIGRTATLIGVDYGN
|   | .||. ..      ||  ..  .. .         . ..|.      |        | |..|. ||.  .  | |...  |. ..|||. ..   
vtvpGslrienlkvdsk..adplfrvtklklvGgd..deerflehwqg....dvnnssdvysplrvlrklrnlsk..pvvvqdilGvskaatlvaieial

QRI--GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA--DRMV
  .  | .    ||  |  .|. |  .|.|  ...|.   ..   | |
lsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 132-377 1.1e-26 88.2 In-house 30-293 (301) alignment
Range on Protein: 132-377
Range on HMM: 30-293/301.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP----DNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 .|.  . .....  |. .|   |  |..|.. |      ...| |...  . .| ..| |||||..|. |||.... ||  ..||... .|.  .|| .
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YIPSEDNISHVCGIYRITKIDQMtmVYADVALQSFEISVTDKSL------------ECPSLVVKHYHFLKWRDHTA---PMTSISVLKLLKALRDPKRPG
| |. .. |.  |   .| ....  || |  .... . ..| |             .  |  |  ..  .| ..     | | . |.      .     |
ywpnseaeseefgpftvtlvneq..vyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg

PPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
| |.|||....|. . . |. |       |  .| .... .|. . .||.   |....   |   .
pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 132-375 2.4e-21 71.0 In-house 23-257 (267) alignment
Range on Protein: 132-375
Range on HMM: 23-257/267.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCsrYIPS
||.     .|  |. |. | |  | |||.|...  ....| | ..     |  .|  |.|...|. ||. ..  .| | .|..    .| |..   . | 
stisqsiaeknqernrlddnlpyddtrvilrtk..eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf..wPPk

EDNISHvcgIYRITKIDQMTMVYADVALQSFEISVTDKSLEcpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPGPP-VIHCSAGIGRTATLIG
  .  .      .|    .     |  . ..|. . ..|       |  |.. ||   |     .  |  . |  . .  ..| |..||.|.||. |.. 
mgqakk...yqdltvehslekeendyqiitlelkfknesah....nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflv

VDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
.|   .|. . | ... | .|..|. |   |..  ..|..   .|.
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 112-373 3.6e-21 69.9 In-house 19-281 (302) alignment
Range on Protein: 112-373
Range on HMM: 19-281/302.0
FVDELDCKKLMRDFVALRAPSTCV--ADTMKKHSEKCRYYDILCPDATRVVLQNRPpdNDFIHANWMTMPDKFR-YISAQGPMDQTV---EDFWHMVYTE
.|..||  .. ..| .. .  . .    . ||...|..  |. ..|...| |...|  .....|  ...|.  |  | || |  ...   |.||.||. |
lvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep..dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

KAPAVVMICDWEEDGIqKCSRYIPSEDNISHVCGIYR--ITKIDQMTmvyADValQSFEISVTDKSLeCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKA
|   ||..   ||      | ..| . .  .  |  .  . |....    ...  . . | |  .     |.... |..  |.... |.   .. |  . 
kivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekae...eek..tryviEvlPegc.snsvlanvyvltnWkqkkvpvkyaeliktaak

L--RDPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
.  .. |   . ||    |.|| .... .    ... .  | |. .||. .|. | .||.| .|.... ...
vfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 144-373 2e-20 67.8 In-house 49-340 (350) alignment
Range on Protein: 144-373
Range on HMM: 49-340/350.0
EKCRYYDILCPDATRVVLQ--NRPP--------DNDFIHANWMTMP-------DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 | || .||  . .|| |.   ...         ||.| ||.. ..        .|.||..|.|. .||.||.....  | . .... .  | ...|| |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YIPSEDNISH----VCGIYRITKIDQMTMVYADVALQSF-------------EISVTD-KSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLK------
| .  .   .          |. |.....  |||  ..              . |.|. .   .  .|| . .. .|.| .  .  .|.|. |.      
YWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndli

------ALRDPKRPGPPVIHCSAGIGRTATLIGVDYGNQ----------RIGEVGEM-----NVLDIVREMRQMRDKAVQSHHQFIFMLMCI
         | .|  | ..|||||.||| ||. .|.  .          .  ..  .      .  || |.|. | . ||. .||||.  ..
ddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal

0048076 (Phosphotyrosine protein) phosphatases II 271-373 1.9e-19 65.2 In-house 41-139 (145) alignment
Range on Protein: 271-373
Range on HMM: 41-139/145.0
ECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP-KRPGPPVIHCSAGIGRTATLIGVDYGNQrigevGEMNVLDIVREMRQMRDKAVQSHHQFIFM
| ..  . .|..| | ||..|  .  .|..|.....  |..|| ..|||||.|||.||.. .   .       ... ......|..| .||.. .|..|.
ellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

LMCI
....
yefe

subfamily_ptpA1_pd Subfamily ptpA1 130-328 9.7e-19 62.4 In-house 35-247 (418) alignment
Range on Protein: 130-328
Range on HMM: 35-247/418.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
 ||       |. . | || .||  . ||| |..      .|.| ||..      ..| .|||. .|. |||.||. ...  .||.    |.   || ||
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

IPSEDNiSHVCGIYRITKIDQMT-MVYADVALQSFEISVTD----KSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--------PKRPGPPV
 | .        ||   .    |  |     .|  |  .       ..|  .  . .|..  | ||  |  .  . .||... .          |  | .
wpeqig.geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

IHCSAGIGRTATLI
.|||||.||| |. 
vhcsagvgrtgtfc

0048179 (Phosphotyrosine protein) phosphatases II 271-371 1.6e-18 62.3 In-house 43-139 (144) alignment
Range on Protein: 271-371
Range on HMM: 43-139/144.0
ECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP-KRPGPPVIHCSAGIGRTATLIGVDYGNqrigeVGEMNVLDIVREMRQMRDKAVQSHHQFIFM
|..   . .|..| | || .|  .  .|..|.....  ...|| ..|||||.|||.||.  .        .  ... ......|..|  ||.. .|..|.
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

LM
|.
le

subfamily_CG42327_pd Subfamily CG42327 143-304 1e-17 58.8 In-house 29-190 (319) alignment
Range on Protein: 143-304
Range on HMM: 29-190/319.0
SEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNIS--H
 .| |. ...    ||||||. . |  . ...|...  .|.    ||.|| .....  ||| .|.  ..  .| ..|  | ||..|..|.|...     .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

VCGIYRITKIDqmTMVYADVALQSFEISVTDKSLecpSLVVKHYHFlKWRDHTAPMTSISVLKLLKAL
. | ...|  .    |    |. .. .   ||..   |  . || . || .   |    ... .|   
lyGdilvtlkg..revkdryaistlllkrvdkee...srelthywy.kwleaevPaeeaaliamllev

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 131-382 1.2e-16 55.2 In-house 36-284 (303) alignment
Range on Protein: 131-382
Range on HMM: 36-284/303.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQnrppDNDFIHANWMTMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMI-CDWEEDGIQKCSRYIP
| .   . . |  .| |. |..| | ..| |     |  .|||... .  . . | .| |. .|  ||| |.  .|   |...  | | | .   | .  
ppsvsknqfvknmdknrfvdvicldhskvkls....dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr

SEDNISHVCGIYRITKIDQMTMVyADVALQSFEISVTDksLECpSLVVKHYHflKWRDHTAPMT-----SISVLKLLKALRDPKRPGPPVIHCSAGIGRT
 .| .       |. .. .. ..    .|.   .|  |    .  | |.||.  .|   . |          . .|   ||      |.|    .| ||.
nqdflkfeersirvgefkrvelg.dgwvlkvlsvsngd..yks.flhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgra

ATLIGVDYGNQRI-GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGV
 |.   .     .  |   ....  .  .|. | .|||   || ..   .|. .. .|.
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 182-368 1.8e-15 51.7 In-house 5-197 (199) alignment
Range on Protein: 182-368
Range on HMM: 5-197/199.0
FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDqmTMVYADVALQSfeISVTDKSLECPSL-VVKHY
 |||..| |. .|. ||| ||.   .  .||. | . .     . | |. .. .   |   .|       . .| .. .  . .|...   ||   . ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittkpdytita..liltnnttappstreishy

HFLKWRDHTAPMTSISVLKLLkALR------DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEvGEMNV---LDIVREMRQMRDKAVQSHH--QFIF
 |  |...|.|  .. |  .. | |      . ..  | ..||| | | |  .. .| | .   |     |   ... . .|| |   . | .  .||.
qftswkekttpnvalfvgfvv.asrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 182-368 1.8e-15 51.6 In-house 4-196 (198) alignment
Range on Protein: 182-368
Range on HMM: 4-196/198.0
FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDqmTMVYADVALQSfeISVTDKSLECPSL-VVKHY
 |||..| |. .|. ||| ||.   .  .||. | . .     . | |. .. .   |   .|       . .| .. .  . .|...   ||   . ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittkpdytita..liltnnttappstreishy

HFLKWRDHTAPMTSISVLKLLkALR------DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEvGEMNV---LDIVREMRQMRDKAVQSHH--QFIF
 |  |...|.|  .. |  .. | |      . ..  | ..||| | | |  .. .| | .   |     |   ... . .|| |   . | .  .||.
qftswkekttpnvalfvgfvv.asrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 274-413 2.6e-13 44.1 In-house 88-224 (440) alignment
Range on Protein: 274-413
Range on HMM: 88-224/440.0
SLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK---RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMl
| ..|.||.  | |.  |  .  |||... . . .     || ..||||| |||. .| ||   .      ..... ..  ||. | . ||. .|. |. 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv.

mciaDRMVLDGVPQNDNMLdLADFYTEFMKKVLMERKKKDEAE
       ||.|.   | .. | |  || .... .   . |.. 
....heavlegllcgdtli.ledditerveqiqwpnphtdksp

subfamily_eak_pd Subfamily eak 168-294 1e-12 42.1 In-house 78-198 (332) alignment
Range on Protein: 168-294
Range on HMM: 78-198/332.0
NDFIHANWMTMPDKF-RYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDQmtMVYADVALQSFEISVT
. .| |  . ...   .|| .  . .. |  || ||. .|.||.|.. .  | ...|  .| | .       ||. ... .   .  . .  . .|.|. 
lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrniletrllelskG

DKSLEcpslvVKHYHFLKWRDHTAPMTS
... .     |.||..  | . | |.  
nethr.....vlhykvfGwtettlpkye

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 185-369 7.2e-11 35.3 In-house 118-301 (346) alignment
Range on Protein: 185-369
Range on HMM: 118-301/346.0
ISAQGP---MDQTVEDFWHMVYTEKAPAVVMICDweEDGIQKCSRYIPSEDNishvcGIYRITKIDQMTMVYADVALQSF--EISVTDKSlECPSLVVKH
| || |    .  |||||.|.| |.   | ..    .| ... .  .  ..|     | |. |    .    |||. .     | |  .  .  |.... 
ivaqlpqmenesfvedfwymiyqeqihlvylmvp..ddklkntttslfnden.....ggyqytgkmfinnrradvsgdpkeytievlpeg.nsdsvicqv

YHFLKWRDHTAPMTSISVLKLLKALRDPKR---PGPPVIhCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFM
.|   |.    |  .. ..|... .   |.    |  |.    | ||. ..||  |  ... .  | |...|.....| |  .|.|  |.  .
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasi

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 168-229 7.8e-11 35.9 In-house 90-154 (349) alignment
Range on Protein: 168-229
Range on HMM: 90-154/349.0
NDFIHANWMTMPD---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
.|.| ||.. ..    ...||. | |.  ||.||....  .. . |. . | .| ...|| .|  
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq

subfamily_CG42327_pd Subfamily CG42327 310-370 6e-10 33.3 In-house 247-308 (319) alignment
Range on Protein: 310-370
Range on HMM: 247-308/319.0
PGPPVIHCSAGIGRTATLIGVDYGNQRIGEV-GEMNVLDIVREMRQMRDKAVQSHHQFIFML
 || |.||| |.||| ..|  |   ... |    ... ..|  .|. | .||.. .|. |. 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy

0038934 (Phosphotyrosine protein) phosphatases II 276-368 5.5e-09 31.4 In-house 79-168 (194) alignment
Range on Protein: 276-368
Range on HMM: 79-168/194.0
VVKHYHFLKWRDHTAPMTSI--SVLKLLKALRDPKRPGPPVIHCSAGIGRTATLIGVDYgnqriGEVGEMNVLDIVREMRQMRDKAVQSHHQFIF
 ......    |.|.| ..|  . |.|..   . . .|  ..|| ||.|||.||..         ..  |.. . .. .|..| .|... ...  
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdylea

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 124-220 8.9e-09 29.3 In-house 19-123 (347) alignment
Range on Protein: 124-220
Range on HMM: 19-123/347.0
DFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQN-----RP--PDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICD
. .|  .|| . .   .|  .| |  |    |||||||        .  . . .| |  . . . .  || .| |. .|| |||.||.  |   || | .
enlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

WEEDG
  .| 
pikde

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 306-372 3.4e-07 24.4 In-house 224-290 (297) alignment
Range on Protein: 306-372
Range on HMM: 224-290/297.0
DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMC
.  |. . ..|||||.||.  ..  |   ...      .|  |.. .|. | . ||. .|| ..   
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda

Spore_coat_CotO Spore coat protein CotO 18-91 2.9e-06 13.2 Pfam-A 31-102 (185) alignment
Range on Protein: 18-91
Range on HMM: 31-102/185.0
VVEKKVDKK-GKKNGSKEEKSRNPEKEEKskfKDLKEEKSKVPDDGKKQEDKKEVKKEEKKKDEKNKKSKNRKSK
.. || ..|  .|. |.|.|  ..|....   .|| .|...  .  .........|.|| ........ .... .
fiikkekekeeekeksnekkeekkeeqke...edleveseeeaeepesedeqesakqeeieqevekeeeeeeeke

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 314-373 3.8e-06 21.2 In-house 2-61 (69) alignment
Range on Protein: 314-373
Range on HMM: 2-61/69.0
VIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
|.|||.| ||| |.| .     ||     ..... |. ||. |   |    ..||.   .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal

subfamily_PTPDC1_pd Subfamily PTPDC1 280-366 8.6e-06 20.3 In-house 85-165 (182) alignment
Range on Protein: 280-366
Range on HMM: 85-165/182.0
YHFLKWRDHTAPMTsISVLKLLKALRDPKRPGPPVIHCSAGIGRTATLIGVDygnqrIGEVGEMNVLDIVREMRQMRDKAVQSHHQF
.. . |.|. ..    ..| . | .    . |   .|| || |||  || .      .  . ...  . .. .|. | |..|...| 
vynfgwkDygvasl.eriLdivkvvafalqegkvavhChaGlGrtGvliacy.....lvyakrltaekaiklvrskrpksiqtreqv