Gene F20H11.4 in Caenorhabditis elegans

Synonym: CELE_F20H11.4, F20H11.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf15
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP064_AA protein Get Run
CeleP064_AA_104-378 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0036941 (Phosphotyrosine protein) phosphatases II 121-375 1.1e-72 240.1 In-house 18-275 (297) alignment 
Range on Protein: 121-375
Range on HMM: 18-275/297.0
LMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLqnRPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEED
 ..... | .. .. .   ... ||.|| |||. | |||.|   ....|.|.|......| |...| .|||...||||||.||. .. . .||.....|.
efeellpllllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

GIQKCSRYIPSEDNISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PK--RPGPPVI
| .|| .| |.| . | ..| ...| ..  .. ..|. |  .|.. |...   .|..|.|.|...| || .| .  |.|......|.  ..  ..|| ..
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCSAGIGRTATLIGVDYGNQRIG---EVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
|||||.||..|.|..|.  |..    . |....|..|...|..|  |||.  |..|. .....
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 121-380 4.7e-72 238.3 In-house 20-279 (317) alignment 
Range on Protein: 121-380
Range on HMM: 20-279/317.0
LMRD---FVALRAPsTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMIC
|..    .  |  . |.    .... .|.|| |||. |..||.|.. ..  |.|.|.|.....|. | ..| .|||...||||||.||. ..   .||..
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

DWEEDGIQKCSRYIPSedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGP
. ||.| .|| .| |.  . . ..| ...| .. ..  .|.. |  .|.. ...|   .|. |.|.|.. | ||..| .  ..|..|.|.|.   ...||
eleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgds...esrtvthfhytgWpdhgvppspdllldfleavrealedpggp

PVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLD
 ..|||||.|||.|.|....  ... . |...| ..|.|.|..| .|||.  |..|. ..... .   
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0050432 (Phosphotyrosine protein) phosphatases II 125-375 7e-72 237.7 In-house 51-297 (308) alignment 
Range on Protein: 125-375
Range on HMM: 51-297/308.0
FVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLqnrPPDNDFIHANWMTMP---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGI
. ..  . .. .  .... .|.|| |||. | .||.|   ....|.|.|......    . ..| .|||...||||||.||. .. . .||... .|.|.
llsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengr

QKCSRYIPSEDN-ISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPGPPVIHCSAG
.|| .| |.| .  | ..| ...| .....  ..|. .  .|.. ....   .|..|.|.|.. | || .|    ..|..|...|.  ..|| |.|||||
ekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaG

IGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
.|||.|.| .|.  ... . |...|...|. .|..|  .||.  |..|. .....
vGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralle
0045450 (Phosphotyrosine protein) phosphatases II 95-374 2e-70 233.3 In-house 2-301 (307) alignment 
Range on Protein: 95-374
Range on HMM: 2-301/307.0
PPDTQELANKKKFCNWFFVDELDCKKLMRDFVALRAPSTC------VADTMKKHSEKCRYYDILCPDATRVVLQNRP---PDNDFIHANWMTMP------
.... .. . .|.. ..... ||.. ...       . |.       .  .... .|.|| |||. | |||.|.. .   .|.|.|.|.....|      
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdNISHVCGIYRITKIDQMTmvyaDVALQSFEISVTDKSLECPSLV
    | ..| .|||...||||||.|.. ..  ..||... .|.| .|| .| |.| . . ..| ...| .. ..    .  .. . . |||.. . .|. 
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh....ldgytvrtlevtdldgtgesrt

VKHYHFLKWRDHTAPMTSISVLKLLKALRD----PKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGE---MNVLDIVREMRQMRDKAVQSHHQFIFM
|.|.|...| ||..| .  ..|......|.     ...|| ..|||||.|||.|.|. ..  ... . |.   ...|..|...|..| .|||. .|..| 
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

LMCIA
 ....
yeall
0039614 (Phosphotyrosine protein) phosphatases II 92-374 1.5e-68 226.7 In-house 12-286 (297) alignment 
Range on Protein: 92-374
Range on HMM: 12-286/297.0
MKPPPDTQELANKKKFCNWFFVDELDCKKLMRDFValraPstCVADTMKKHSEKCRYYDILCPDATRVVLQNRP---PDNDFIHANWMTMPD--KFRYIS
.  | . ..|..... .| . . .|. ..|.. ..    .  ..    ... .|.|| |||. | .||.|.  .   .|.|.|.|......|  . ..| 
ipiplsvldlllllekansktllllefeellslkp....d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

AQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIqKCSRYIPSEDNishVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecpsLVVKHYHFLKWR
.|||...||||||.||. .. ...||... .|.|  || .| |.| .   ..| ...| .. ..  .... .  .|.. ...|     . |.|.....| 
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnnges.....rtvthfqytgwp

DHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
||..| .. ..|..|...|.      ..|| ..|||||.|||.|.|. ..  ... . |...||..|.|.|..| .|||. .|..|  ....
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall
0046845 (Phosphotyrosine protein) phosphatases II 132-375 1.9e-68 226.2 In-house 18-272 (284) alignment 
Range on Protein: 132-375
Range on HMM: 18-272/284.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD---NDFIHANWMTMP------DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQ
 .. .  .... .|.||.|||. | .||.|.. ..|   .|.|.|......       | ..| .|||...||||||.||. .... .||.....|.| .
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCSRYIPSEdNISHVCGIYRITKIDQMTmvYADVALQSFEISVTdkSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP----KRPGPPVIHCS
||..| |.| . . ..| ...| .. ..  . |. .  .|.. .  ... .|. |.|.|...| || .| .. ..|..|...|.     ...|| |.|||
kcaqYwple.gevltygdftvtllseev..kddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCs

AGIGRTATLIGVDYGNQRIGEVG---EMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
||.|||.|.| .|.  ... . |   ...||..|. .|..|  .||.  |..|  .....
aGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle
0051299 (Phosphotyrosine protein) phosphatases II 127-375 2.8e-67 222.5 In-house 34-284 (288) alignment 
Range on Protein: 127-375
Range on HMM: 34-284/288.0
ALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQK
.| .. |. |  .... ||.||.|||. | .||.|.. ..  ..|.|.|..... . | ..| .|||...||||||.||. .. . .||.....|.| .|
sllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrek

CSRYIPSedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTD-KSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAG
| .| |.  . | ..| ...| .. ..  ..|. .  .|.. .|  . .  |. |.|.|...| || .| .  ..|..|...|.   ...|| |.|||||
caqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaG

IGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
.|||.|.| .|.  ... . |...||..|. .|..|  .||.  |..|  .....
vgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0047943 (Phosphotyrosine protein) phosphatases II 129-374 1.2e-66 220.3 In-house 25-269 (273) alignment 
Range on Protein: 129-374
Range on HMM: 25-269/273.0
RAPSTCVADTMKKHSEKCRYYDILCPDATRVVLqnRPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
  . |. .  .... .|.||.|||. | .||.|   ....|.|.|....... | ..| .|||...||||||.||. .... .||.....|.| .|| .|
kplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqY

IPSEDNI-SHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSLecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD----PKRPGPPVIHCSAGIG
 |.| .  | ..| ...| ....|  ..|. .  .|.. .. .    |..|.|.|...| || .| .  |.|......|.     ...|| |.|||||.|
wpleggelsltygkftvtllseet..kddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvg

RTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
||.|.| .|.  ... . |...||..|. .|..|  .||.  |..|. ....
RtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
DSPc_SM00195 130-376 1.5e-66 219.8 In-house 14-261 (263) alignment 
Range on Protein: 130-376
Range on HMM: 14-261/263.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 |...     || ..| || .||. | ||| |....  ...|.|.||.....  | .|| .|||...||||||.||. || . .||... ||.| .||.|
spketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YIPSEDNISHVCGIYRITKIDQMTMVyADVALQSFEISVTDKsleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR--PGPPVIHCSAGIGRT
| |.| . . . | .... ... ..  ... |. .|.. ..|     .  |..|.. .| || .| .  |||.||.|..  |.   || |.|||||.|||
ywpeesggketfgkisvklvevekkk.deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.|.. .|.  ... |  .... .||.|.|. | ..||.. |..|. ..|.. 
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 130-376 1.5e-66 219.8 In-house 14-261 (263) alignment 
Range on Protein: 130-376
Range on HMM: 14-261/263.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 |...     || ..| || .||. | ||| |....  ...|.|.||.....  | .|| .|||...||||||.||. || . .||... ||.| .||.|
spketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdr

YIPSEDNISHVCGIYRITKIDQMTMVyADVALQSFEISVTDKsleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR--PGPPVIHCSAGIGRT
| |.| . . . | .... ... ..  ... |. .|.. ..|     .  |..|.. .| || .| .  |||.||.|..  |.   || |.|||||.|||
ywpeesggketfgkisvklvevekkk.deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRt

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.|.. .|.  ... |  .... .||.|.|. | ..||.. |..|. ..|.. 
gtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
Y_phosphatase Protein-tyrosine phosphatase 143-374 1.7e-66 219.3 Pfam-A 2-234 (235) alignment 
Range on Protein: 143-374
Range on HMM: 2-234/235.0
SEKCRYYDILCPDATRVVLQNRPPDNDFIHANWM-TMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIY
..|.|| |||. | ||| |.... ..|.|.||.. . ..|...| .|||...|.||||.||. ||  ..||... || | .||..| |.|.. |  .| .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

RITKIDQMTMVYADVALQSFEISVTDKSLecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGE
...   . .   ....|. .|.. ....    .  ||..|. .| ||..| .. |.|.|.....  |  . || |.|||||.|||.|.. .|.  ... .
kvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
 .|..||.||.|.|. | ..||| .|.||. ..|.
eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 143-374 1.7e-66 219.3 In-house 2-234 (235) alignment 
Range on Protein: 143-374
Range on HMM: 2-234/235.0
SEKCRYYDILCPDATRVVLQNRPPDNDFIHANWM-TMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIY
..|.|| |||. | ||| |.... ..|.|.||.. . ..|...| .|||...|.||||.||. ||  ..||... || | .||..| |.|.. |  .| .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

RITKIDQMTMVYADVALQSFEISVTDKSLecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGE
...   . .   ....|. .|.. ....    .  ||..|. .| ||..| .. |.|.|.....  |  . || |.|||||.|||.|.. .|.  ... .
kvelkekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
 .|..||.||.|.|. | ..||| .|.||. ..|.
eeevdvlqivkelRkqRpgmvqsleqYiflykail
0043336 (Phosphotyrosine protein) phosphatases II 130-374 4.9e-65 215.1 In-house 34-274 (278) alignment 
Range on Protein: 130-374
Range on HMM: 34-274/278.0
ApSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
   |.     ... .|.|| |||. | .||.|.. . |  .|.|.|....... . ..| .|||...||||||.||. .. . .||... .|.| .|| .
l.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaq

YIPsedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSLEcpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRT
| |   . | ..| ...| .....  ..|. .  .|.. . .. .   . | |||.|.| ||..| .  ..|..|||.|.   ...|| ..|||||.|||
Ywp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRT

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
.|.|....  ...   |.......|.|.|..| .|||.  |..|  ....
GtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 116-374 6.2e-65 214.7 In-house 7-269 (278) alignment 
Range on Protein: 116-374
Range on HMM: 7-269/278.0
LDCKKLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVlqnrppdnDFIHANWMTMPdKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICD
||..  .  ...|  ||..    . .. .|.||.|||. | .||.        |.|.|...... ....| .|||...||.|||.|.. .. ...||...
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmlte

WEEDGIQKCSRYIPSedNISHVCGIYRITKIDQMTMvyADVALQSFEISV-TDKSLECPSLVVKHYHFLKWRDHTAPMTS--ISVLKLLKALRDPK----
 .|.| .|| .| |.  . | ..| ...| .. ...   |. |  ...   | .  ...|. |.|.|.| | ||..| ..   |.|.||. .|.      
lvelgrekcaqywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------RPGPPVIHCSAGIGRTATLIGVDYGNQRIgEvGEMNVLDIVREMRQMRDK-AVQSHHQFIFMLMCIA
           ..|| ..|||||.|||.||.....  ... | | ...|..|.|.|..|   |||. .|..|. ....
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefll
0042113 (Phosphotyrosine protein) phosphatases II 140-374 1.8e-61 203.0 In-house 7-240 (245) alignment 
Range on Protein: 140-374
Range on HMM: 7-240/245.0
KKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSedNISH
... .|.||.|||. | |||.|.. ..|  .|.|.|....... . ..| .|||...||||||.|.. ..  ..||... ||.| .|| .| |.  . | 
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesl

VCGIYRITKIDQMTmvYADVALQSFEISVTdksLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD---PKRPGPPVIHCSAGIGRTATLIGVDYG
..| ...| .. ..  ..|. .  .|.. .    . .|. | |||.| | ||..| .. ..|..|...|.    ...|| ..|||||.|||.|.|.... 
tygdftvtllseeh..lddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

NQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
 ... . ..... ..|.|.|..| .|||. .|..|. ....
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 133-374 6.2e-61 201.5 In-house 2-243 (249) alignment 
Range on Protein: 133-374
Range on HMM: 2-243/249.0
TCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
..    .... .|.||.|||..| .||.|.  |   ..|.|.|....... | |.| .|||...||||||.|.. ..  ..||... .| | .|| .| |
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SedNISHVCGIYRITKIDQMTmvYADVALQSFEISVTdksLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGRTA
.  . | ..| ...| .. ..  ..|. .  .|.. .    . .|. |.|.....| || .| .  ..|....|.|.      ..|| ..|||||.|||.
l..ggsleygdftvtllsvev..kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtG

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
|.|. ..  ... . ........|...|..| .|||. .|..| .....
tfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 119-385 1.1e-57 190.2 In-house 12-278 (285) alignment 
Range on Protein: 119-385
Range on HMM: 12-278/285.0
KKLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDW
 || .| .    |  |   . .   .  || |. | . |||||.|.  | |.|||.|| || |    ||..|||. .|. |||||.| ||   |.|.|  
sklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknh..drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctl

EEDGIQKCSRYIPSEDNISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSLECPsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PKRpGPPV
 | |..||. | | .       | | ||  .      |   |... .  |. .   | | ..| .   | |. ||  .  ...| | ..   ||   | .
feggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedassep.lymnhvqvpwwpdqlapedarpmielykwvkkvnpke.kpic

IHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGVPQN
.|||||.|||||..|.||   || |  ....|||||||| || .||||| ||.|. . . . .. .|| . 
vhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvver
0037934 (Phosphotyrosine protein) phosphatases II 139-374 1.2e-57 190.6 In-house 7-239 (243) alignment 
Range on Protein: 139-374
Range on HMM: 7-239/243.0
MKKHSEKCRYYDILCPDATRVVLqnrpPDNDFIHANWMTMPDkfRYISAQGPMDQTVED----FWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPseDNI
.. . .|.||.|||. | .||.|    ...|.|.||......  |.|  |||...||||    ||.|.. ..  ..||.....| | .|| .| |  ...
lpenlsknrysdilpydhsrvkl....egsdyinanliyvtp..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev

shVCGIYRITKIDQMTmvYADvaLQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD----------PKRPGPPVIHCSAGIGRT
  ..| ...| .....  ..|     ...... ..|. ... | |||.| | ||..| .  ..|..|...|.           .. || ..|||||.|||
..tygdftvtllseeh..ldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

ATLIGVDYGNQRIgevgEMNVLDIVREMRQMRDK-AVQSHHQFIFMLMCIA
.|||  ..  ...    .......|...|..|   |||. .|..|  ....
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRD_pd Subfamily PTPRD 132-430 8.7e-54 178.1 In-house 38-325 (564) alignment 
Range on Protein: 132-430
Range on HMM: 38-325/564.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYI
.|. | ...   .| || .|.  |..||||.. .  .. |.| |...     .  || .|||. .|.|||| ||. ..   .||.   || | .||..| 
ftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYW

PSEdNiSHVCGIYRITKIDQMTMvyADVALQSFEIsVTDKSLECpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTAT
|.. . .  .| . .|  .. ..  ||. . .|..  . || |     |...|| .| || .| .  |.|.|..  |.   .  || |.|||||.||| |
Pek.g.tetygeltVtleeeeel..adyeirtfkl.kkkksses..reVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIadrmvLDGVPQNDNMLDLADFYTEFMKkvLMERKKKdeAEKAKKEKEEKRKRD
 | .|.  .|| | . ...  .|...|. |.  ||...|.||.   |     |. .   .. ..  .......|  |.| ...   | .. |.| .|   
fividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai.....lealacgntevesenlkqhlqk..Laeveed..temtgleleFqrLat

EAND
  ..
akei
subfamily_PTPRB_pd Subfamily PTPRB 131-377 1.3e-51 170.4 In-house 40-285 (293) alignment 
Range on Protein: 131-377
Range on HMM: 40-285/293.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
  ...|.. .. ..| || .||  |..|| |   .  ...|.| ||..     .  .|..|||. .||.|||.||. .|. ..||. .  | | .|| .|
dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeY

IPSEDNiSHVCGIYRITKIdqMTMVYADVALQSFEISVtdkslECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGR
 |.... ... |  ..| .  .. .. | ......|.      |  .  |..|||. | ||  | .. ..|......|. .    . .| |.|||||.||
WPadee.pvlyGdikvtlv..aeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGR

TATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
| |.| .|   |.| |   .... || |.|. |   ||. .|.||.  |. | .
tGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN12_pd Subfamily PTPN12 137-376 1.1e-50 167.1 In-house 35-276 (290) alignment 
Range on Protein: 137-376
Range on HMM: 35-276/290.0
DTMKKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN
 . ... .| || |||  | .||.|..   .  .|.| ||..  .. | .||.||||. .|..|||.|..  .   |||.|   | | .|| || |.| .
gekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeege

ISHVCGIYRITKIDQMTmVYADVALQSFEISVTdksleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTATLIGVD
 .   | ...|.... . |  |  ...... .        | .|. .|. .| ||  | .  |.|.|....|.   .   | |.|||||.||| |.| .|
eelefgefevtleeeka.vdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

YGNQRIGE--V-GEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
|  . . .  .  |..| |.|.|.|. |  .||.. |. .. ...|. 
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPN13_pd Subfamily PTPN13 120-371 2e-48 160.0 In-house 15-263 (273) alignment 
Range on Protein: 120-371
Range on HMM: 15-263/273.0
KLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPdndFIHANWMTMP---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDW
. ....  |..  ||     |.. .| || ..|  |.||| |..  .   .| |... .|   |...|| .|||. .||.||| ||.  ||  ..|.   
eefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

EEDGIQKCSRYIPSEDNIShVCgIYRITKIDQMTMVYADVaLQSFEISVTDKSLeCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR-PGPPVI
 |.|  || || |.. | . .  ..   ..... ..  |  ..  .. |.|.     |  | | .| || ||  | .. ..|.... .|  ..  || |.
kekgkvkchrywPesknkk.lk.vsnrlevellkvqkldg.fvvralavkdses.gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivv

HCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLM
||||||||. ||| .|   . |    |..| .|||..|. |.  ||.. |.||.  
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvyk
subfamily_PTPN9_pd Subfamily PTPN9 113-373 4.7e-48 158.7 In-house 10-286 (297) alignment 
Range on Protein: 113-373
Range on HMM: 10-286/297.0
VDELDCKKLMRDFVALRAPS---TCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEK
| | . . |.......|. .   |  |  ..  .|| || |.|| | |||||.... |   |.|.||..     |  .|..|||...||.||| ||. ..
vkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqe

APAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD
.  .||.   .| |  ||..| |.|.. |.  | ........ .  . |   ...||. ....    |  | |. || | |.  | .. |.|..|.. |.
vlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee..eedykvrvleiknvkte...esrkvthfqflsWPdyGvPssaaslldvlekvre

P--------------KRPGPP-VIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
               .  ||| |.||||||||| |.| .|.  .|. ||| ..| . |. .|. |  ..|  .|. |  ...
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 118-373 6.2e-48 158.2 In-house 4-264 (274) alignment 
Range on Protein: 118-373
Range on HMM: 4-264/274.0
CKKLMRDFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPDN---DFIHANWMTMPDKF--RYISAQGPMDQTVEDFWHMVYTEKAPAVVM
 |.| ..|. | .  .    .. ....| || .||  . .||.|... ...   ..| ||..  .|.    |...|||. .||.|||.|.|.|... .||
fkdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

ICDWEEDGIQKCSRYIPSEDNIsHVCGIYRITKIDQMTMVY-ADVALQSFEISVTDKSLEcpslvVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK---
. . .|   |||..| | . .. .. . |   .|    .|   |  .... .. . .. .     |||| . .| || .|    ..|.|..  .. .   
ltklkeaneqkCavyfPdaedy.eiserygdveikvekiverndysvrklvlkylerers.....vkhywytdWPdhksPddantlldlvleveesreee

--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
  . .| |.|||||||||   |... . ... | . ..|| || ..|. |   ||...|. ..   .
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_PTPN3_pd Subfamily PTPN3 139-374 7.3e-48 157.9 In-house 38-272 (280) alignment 
Range on Protein: 139-374
Range on HMM: 38-272/280.0
MKKHSEKCRYYDILCPDATRVVLQNRPPdnDFIHANWMTMP--D---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN
. .  .| || |||  ||||| |.. .   |.| ||.. |         |||..|||...|..|||.||. .|.  .||. .  |.| .|| .| |....
kpenlsknryrdilpydatrvklkeset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPeted

ISHVCgIYRITKIDQmtmvYADVALQSFEISVTDKSLEcPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVD
 ..    ....   .     .. .    |. ..||. .  .  . .  .| | ||. |  | ..|.... .|. .  .  | |.|||||||||  || ..
eleyg.efsvkceke....detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlille

YGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
   . | .  ....|||||.||. |   ||...|. |.  .| 
talalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 125-377 1.1e-47 157.5 In-house 21-276 (281) alignment 
Range on Protein: 125-377
Range on HMM: 21-276/281.0
FVALRA---PSTCVADTMKKHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEE
. .|.|    .| .| . ..  .| || .|   |||||..  ...  ..|.| ||..  . .. .|| .|||. .....||.||. .|. |.||.    |
yeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreie

DGIQKCSRYIPsEDNISHVCGIYRITKIDQMTMvyADVALQSFEIsvtdKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKAL---RDPKRPGPPVI
 |  || || | .|| .   | ...... . .   |  . . |..    .  ....  |.. ....| || .| |.  .|.  |..   ...|.  | ||
agklkChrYWP.ddnselkygdvtvkstaeeek..atyierkfkl....eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvi

HCSAGIGRTATLIGVDYGNQRI-GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
|||||.||| | |..|   ...  |  |..| ..|.|.|. |   ||.  |. |.   . | .
hCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 143-375 4.9e-47 155.0 In-house 57-281 (290) alignment 
Range on Protein: 143-375
Range on HMM: 57-281/290.0
SEKCRYYDILCPDATRVVLQNRpPDNDFIHANWMTMpDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYR
 .| || |. | | |||.|..   | |..|||..    |  .| .||.. .|| |.| ||  ||. |.||.|.  |||  ||..| | ..      | . 
fkknrykdvvcndktrvilkdG.ydGdyvhanyvkG.lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

ITKIDQMTmvyADVALQSFEISVTDKSlECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRdpKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGE
..   . .    |  ..   .|| ||  .  . ..||..   | |.. .......|..|..||  | .|| |.||||||||| |.. .. | | . .  |
vlcseedd...kdaniikktlsvrdkd.sGkehklkhlkikswpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilldGke

MNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
...||.|| .|. | ..||   |.. ..  . |
ldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPRA_pd Subfamily PTPRA 117-376 1e-46 154.4 In-house 30-294 (330) alignment 
Range on Protein: 117-376
Range on HMM: 30-294/330.0
DCKKLMRDFVALRA---PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNR--PPDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAV
|.|..  .| || |    .|. . . ..  || |. .||  | .||.|...   .. |.| | ..    .| ..|.|||| ..|||||| |..  |. ..
dnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksati

VMICDWEEDGIQKCSRYIPSEDNISHvcGIYRITkIDQMTmVYADVALQSFEIS-VTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALR--DP
||. . .|   .|| .| |.|  ...  |  |.. ....| |  |.... | .  ..|.. | .| .|. .||  | |   |...| .|||||...  ..
vmltelkerkeekcaqywPdeGlvty..Gnirve.vedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnq

KRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.  || |.|||||.||| |.| .|   .|.   . ..| ..|...|. | . ||.  |. |.   . . 
qsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 119-373 1.8e-46 153.7 In-house 23-279 (319) alignment 
Range on Protein: 119-373
Range on HMM: 23-279/319.0
KKLMRDFVALRAPSTCVAD--TMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMI
..| ..|  |. ...   |  .... ..| || .||  | |||||.. .  .. |.| |...    .. ..|..|.|...|.|||| ||. |..  |||.
tllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvml

CDWEEDGIQKCSRYIPSEDNisHVCGIYRITKIDQMTMvyADVALQSFEISVTDKSLECpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRP---
..  | .  |...| |.|.   .. | . .|  ..  .  .|.  . ...      .|.    |||.....| ||  | .. |.|.||| .|  ..    
tklveklkvklkkywpeenf..eeyGrlivtleeeeel..edyiirklklnkkssevet..RevkhfqyteWpdhdvPekatslldllkrirksrektqs

GPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
|| |.|||||.||| | | .|   .|. | | ..|  .|...|  |.  || ..|..|.   .
gPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 132-381 8.9e-46 151.2 In-house 38-283 (288) alignment 
Range on Protein: 132-381
Range on HMM: 38-283/288.0
STCVADTmKKHSEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYI
|....    .  .| || .||  | .|| |..    ...|.| |...   . | .||..|||. .||.|||..|| .|.  .||. .  |.| .|| .| 
svtagrl.avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYW

PSEDNIsHVCGIYRITKIDQMTMvyADVALQSFEISvtdksLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PKRPGPPVIHCSAGIGRTAT
|..|.  .  |   .| ... ..   |. |.....       .   | ...|..| | ||  |  .  .|.||. .    ..  || ..|||||.||| |
Pdadkp.knyGsvtvtlveskel..edfvlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDG
 | .|   ... |   ..|...| ..|. |   ||  .|..|.  .... .  ||
FialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 137-378 1.1e-45 151.2 In-house 41-281 (318) alignment 
Range on Protein: 137-378
Range on HMM: 41-281/318.0
DTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN
 . .    | || .||  | ||| ||..   .. |.| ||..     |  ||.||.|. .|.|||| ||.  ..  .||. . || | .|. || ||.. 
slepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs

ISHvcGIYRITKIDQMTmvYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD---PKRPGPPVIHCSAGIGRTATLIGV
.|.  |  ...  ....  ..|  |..|... |...    | .|. ||. .| |.  |  . |.|.|..  .    ..  || |.|||||.||| . | |
rsy..gklvvelkeeve..lsdyvlrefkvtrteee...esrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiav

DYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
|   .|| . . ..|...|...|. |.  || ..|..|.   . . . 
dillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPN6_pd Subfamily PTPN6 141-374 2.7e-45 149.7 In-house 53-294 (306) alignment 
Range on Protein: 141-374
Range on HMM: 53-294/306.0
KHSEKCRYYDILCPDATRVVL-QNRPPDNDFIHANWMT---MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
.  || ||  ||  | |||.| ..  |..|.| || ..      . .||..|| ...||.|||.||. |..  .||.    | | .||.|| |.| . ..
enkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

vCGIYRITKIDQMTMvyADVALQSFEISVTDKSLECPSlvVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK------RPGPPVIHCSAGIGRTATLIGV
  | ...|.... ..  ||  | .. .| ..|. |. .  | .||| .| ||  |     ||..|. ..  .      ..|| |.||||||||| |.| .
.yGkisvtnvseksl..adYilRelsvskkkkkkeere..vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfivi

DYGNQRIGEVG---EMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
|   . | . |   .... ..|. .|. |   || ..|. |. . |.
Dillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Ptp69D_pd Subfamily Ptp69D 104-378 3.5e-45 149.4 In-house 16-287 (307) alignment 
Range on Protein: 104-378
Range on HMM: 16-287/307.0
KKKFCNWFFVDelDCKKLMRDfvalRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWH
.|.  .. ..   . .|| .       . ....   |    | || ||   | |||.|.. .   | |.| |...    .|...| ||.|...|..||| 
rkrdtdfglak..eyekLear....eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWR

MVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVcGIYrITKIDQmtMVYADVALQSFEISVTDKSL--ECPSLVVKHYHFLKWRDHTAPMTSISVL
|.   .   .||. . .|   .||..| | ||.. .   |  .. ...      | . .....| ....   .  |  |  ||.. |.| ..| .. ..|
miaeqevtlivmlsnlteknrkkcakYWpiedevqyg.dil.vklvse..ekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargll

KLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
||.. .|. .    .| |.||||| ||..... .|   |.. .  .... ..|...|. |.  ||| .|..|.   ..| . 
klieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRG_pd Subfamily PTPRG 134-374 8.3e-45 148.0 In-house 39-284 (563) alignment 
Range on Protein: 134-374
Range on HMM: 39-284/563.0
CVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DN-DFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
. .   ..  .| || .|.  | .|| |.. |   .. |.| ||..    |   .| .|||. .|..|||.|.. ...  .||| . .|.| .|| .| |
aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWP

SeDNiSHVCGIYRITKIDQMTMVYADVA-LQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRP--GPPVIHCSAGIGRTAT
. |. |  .|  ..| |.. ....  |  |.  .. . .|.     ..|..||. || ||..|  |. ||.  |     ..   || |.|||||.||| |
k.de.setygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
.| .|   ..| .   .||..... .| .|.  ||.. |.||.   . 
yivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 141-373 1.5e-44 147.0 In-house 19-260 (270) alignment 
Range on Protein: 141-373
Range on HMM: 19-260/270.0
KHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT--MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
....  || |||   ||||.|..    .   .| ||..     .| .||.|.||.. |...|| |...||..|.||. . ||.| .||.|| |.| . . 
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

VCgiyRITKIDQMTMV-YADVALQSFEISVTDKSLEcPSLVvkHYHFLKWRDHTAPMTSI------SVLKLLKALR----DPKRPGPPVIHCSAGIGRTA
 .   .  ||  ...    .      .. ...|. |   ||  |... .| ||..| ..       ..||.|.|.|    . .. .| ..|||||.||| 
kl...edgkikvlalseekeegyiltrlrleekgee.rrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtG

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
||| .|.. . . | ....|| |..|.|. | . ||  .|. |.   .
tlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykav
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 131-373 1.2e-43 144.4 In-house 35-279 (305) alignment 
Range on Protein: 131-373
Range on HMM: 35-279/305.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPDN--DFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
....  .. ... .| |. .|   |  |. |.... ..  |.| |...     | .|| ||||...||.|||.... ||   .||...  |.| .|| .|
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

IPSEDNISHVCGIYRITKidQMTMVYADVALQSFEISVTDKslECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPG---PPVIHCSAGIGRT
 | . . ..  | . ..   . .  ..|     ..||. |.  .  | .| .|.. .| ||  | .. |.|.|.| ..  .. .   | ..|||||.|||
Wpesktekkefgefsvel..ksektasdyieRklkisiede..dkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRt

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
 . | ||   .|. . ....| ......|. | |.||.  |. |.   .
GvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 140-373 1.6e-43 143.7 In-house 45-274 (287) alignment 
Range on Protein: 140-373
Range on HMM: 45-274/287.0
KKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNisHVC
..  .| |. .|| ||  ||.|...  ..|.| | ..    .| ..| |..|| .|. .||...  .. .|.||.|. .|.  ..| .| |.|..   | 
sqnkdknRltqilvpdnyrvllkge..hpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvl

GIYRITKIDQMtmVYADVALQSFEISVTDKslECPSLVVKHYHFLKWRDHT-APMTSISVLKLLKALRDPKRP--GPPVIHCSAGIGRTATLIGVDYGNQ
| |.|. ...   |.|..  . .|.  ..|  . . . || |.. .| ..   .    ..| . .  .  ...  .. |.|||...||.|... .. . .
Geyniellnee..vnagyierklevknknk..agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin

RIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
.  . | ..|.......|. . ..||  .|..|.   .
kckteGviDvfqvlksqriqkpgsvqtveqykfindiv
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 131-370 3.5e-43 142.5 In-house 35-276 (290) alignment 
Range on Protein: 131-370
Range on HMM: 35-276/290.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD----NDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCS
. |   .. .. ... |. .|. .|  |..|.. . .    |..|.| ..    .| .|| .|||. .|. |||.... || ...||...  |.| .|| 
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCq

RYIPSEDNIShvCGIYRITKIDQMTMVyaDVALQSFEISVTDKSleCPSLVVKHYHFLKWRDHT---APMTSISVLKLLKALRDPKRPGPPVIHCSAGIG
 | |..|. .   | ..|. ....|.   .   . .|.  ....   ..  |..|..  | ..    .| |...|..     .  .  .. |.|||...|
qYWpdsdtka..ygefsikllneetln..eyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvg

RTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
|.|... .. . ..    | ..|.......|. . . ||. .|. .. 
rsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 124-370 8.1e-43 141.6 In-house 21-270 (307) alignment 
Range on Protein: 124-370
Range on HMM: 21-270/307.0
DF--VALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDG
.|  .| ..| .  .....  ..| || |. | | .|.|..      |.||||.. .  |  ..| ||||...|. .|| |.  ||  .|.|.|.  | .
efrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckviela

IQKCSRYIPSEDNISHVCGIYRITkIDQMTMVYADVALQSFEISVTDKSLE--CPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRpgPPVIHCS
  || .| | |.    | |    | |    .    .| .   | ||.  ..    |  ..|. . .| |. .| . .. . ||.| |  .   | |.|||
kikceqywpleegqklvfgeapnt.isvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtn..pvvvhcs

AGIGRTATLIGVDYGNQR-IGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
||.||. |.... .  .. |  .  ... ..|.|.|. |. |.|.  |.... 
aGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 127-374 1e-42 141.5 In-house 42-287 (298) alignment 
Range on Protein: 127-374
Range on HMM: 42-287/298.0
ALRAPSTCVADTmKKHSEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQK
 ... .. || . ..  .| || ||.  | .||||..     . |.| | ..    ..  .| .|.|. .||||||.||  |.. ..||. . || .  |
eieeeekevark.penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktk

CSRYIPSEDNISHvcGIYRITKidQMTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALR-DPKRPG--PPVIHCSAG
...| |.| .  .  |  ...   . . ..||.. . ...| ....    .  |.. || .| |...| .. |||.||.  |  ... |  | ...||||
yhkywPdegkety..geitvsl..lskeefadlivrklkvskkkee...kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaG

IGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
.||. | | .|   .|. .   . |...|. .|. | .|||...|..|. . . 
vgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_PTPRK_pd Subfamily PTPRK 140-373 3.1e-42 139.5 In-house 41-273 (314) alignment 
Range on Protein: 140-373
Range on HMM: 41-273/314.0
KKHSEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNIsh
... || |. ||| .| .||.|.    |  .|.| |...        .| .|||...||.||| .|| |.. ..||. .  | |  ||..| | . ..  
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..

vCGIYRITKIDqmTMVYADVALQSFEISVTDKSLECpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALR--DPKRPGPPVIHCSAGIGRTATLIGVDYGN
  |  ... ..  | . |..  . | .. . .. |    .|....||.| ||  |.   ..|||.. .   .... |. |.||||| ||| | | .|   
.ygdikvelve..tellaelvvrifrveklargqee.irevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

QRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
. | . | ..|  .|...|. .   |. . |..|.   |
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 141-376 7.8e-42 138.2 In-house 8-241 (250) alignment 
Range on Protein: 141-376
Range on HMM: 8-241/250.0
KHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQkCSRYIPSEDniSHV
.  || || ||.  | .||||..     . |.| | ..   | .  .| .|||. .|.|||| ||. ||. ..||. . .| . . ...|.| |   .. 
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aek

CGIYRITKIDqmTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKR---PGPPVIHCSAGIGRTATLIGVDYGN
 |  ...  .  . ..||.  . . .| . |.    . .|...||. | | . | .  .||.||| ..  ..    .| ...||||.||. . | .|   
yGdvtvslls..keefadytkrklklskakka...derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

QRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
.|. .   ..| .... .|. | .||.|..|..|. . |   
erlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 141-373 3.7e-41 135.8 In-house 47-283 (305) alignment 
Range on Protein: 141-373
Range on HMM: 47-283/305.0
KHSEKCRYYDILCPDATRVVLQNRPPdNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDN--ISHV
....| || |. | |  || |..  |  ..||||... |    |.| .| |...|  |||.| . .|  |. |.|.  | | .||. |..|.|.  ..  
qeagknrykdvgcldnnrvklegpwp.heyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

CGIYRITKIDQMTMVYADVALQSFEISVTDKSLECP---SLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKrpGPPVIHCSAGIGRTATLIGVDYGN
 .  .|.   . .  .  ..  . ... |   .| |   .. |.|||.  | |   | . ...|.||.  |  |  || |.||||||||| ... ..|  
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk..gpivvhcsagigrtgsvvmleyil

QRIGEVGEM-NVLDIVREMRQMRDKAVQSHHQFIFMLMCI
... .   . .   |.. .|. |....|. .|..|.   |
dqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_PTPN1_pd Subfamily PTPN1 138-375 5.7e-41 135.1 In-house 28-269 (290) alignment 
Range on Protein: 138-375
Range on HMM: 28-269/290.0
TMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
 ...  .. || |.   | .|..|..   |||.| |. . ... | .|| .|||. .||. ||.||. .|. ||||.    | . .|| .| |.... . 
klpenrnlnryrdvspydhsriklera..dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeeke

-VCG--IYRITKIDQMTMVYADVALQSFEISVTDKslecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP----KRPGPPVIHCSAGIGRTATLIG
 ..    .... | . .  |  | |  .|   |..     . .. |.|...| | . | .  . ||.|  .|.     .  ||.||||||||||. |.. 
llledtklkvkliseerksyytvrllelenlktqe.....treilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

VDYGNQRIGEVGEM---NVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
||    .| . ...   .. . . |.|..|   .|   |. |  . | .
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 136-377 1.1e-39 131.3 In-house 42-284 (297) alignment 
Range on Protein: 136-377
Range on HMM: 42-284/297.0
ADTMKK---HSEKCRYYDILCPDATRVVLQ--NRPPDNDFIHANWMTMpDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIqKCSRYIPS
..|. .     || || .||  |  || |.  |  || |.. | ..    | |.|. | ||..||.||| ||. |.. ..||. | .|    || || . 
pqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg.nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

EDNIShvCGIYRITkiDQMtmVYADVALQSFEISVTDKSLEcPSLVVKHYHFLKWRDHTAPM--TSISVLKLLKALRDP---KRPGPPVIHCSAGIGRTA
.   .   |   ..   .   |         |..||  .      ||| |.|..| |.. .   .  |.|||.. .|.    .  || ..||.||.|||.
kgvtt..fGdvsvv..lls..vsereGfikrelevtkgkak.arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtg

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
 |. .|    .. .  |......|. .|| | . || . |. |.   . . .
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 142-376 1.1e-39 130.9 In-house 50-280 (301) alignment 
Range on Protein: 142-376
Range on HMM: 50-280/301.0
HSEKCRYYDILCPDATRV-VLQNrpPDNDFIHANWMTMP-DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCG
. .| ||  . |   | | |...       |||||.  . .  |.|..|||...| |||| |.   .   .||..   |. ..||. |.|.. . .   |
pkdkhryptvPckPstavevivd..GkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

IYRITKIDQMTMVYADVALQSfeISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPgpPVIHCSAGIGRTATLIGVDYGNQRIGE
 ..|.  .. ...  ..  ..  . |.| . . ..  | || . .| |.  | . . . .|.. ... ..|   |.||||||||. ..|| .|  ...  
rfkikiknkelilnkkiskrt..levedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekP..ivvhcsaGiGrsvafigteylarevea

VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
  .... . ....|. | ..|| ..|. .| .    |
dptieltealkhlrehrwngvqtnsqlywmtlGtvyr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 99-399 1.6e-39 131.1 In-house 21-311 (319) alignment 
Range on Protein: 99-399
Range on HMM: 21-311/319.0
QELANKKKFCNWFFVDELDCKKLMRDFVALrapSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTV
|.|.||..| .     | . ... .  | |   ..     ...  .| |. .||  | ..| |..       |.| | ..|    | .||.||||.| |.
qqlsnksdfdddltklevefrracklgvnl...adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntl

EDFWHMVYTEKAPAVVMICdweedgIQKCSRYIPSEDNISHVCGIYRITKIDQMTMvyadVALQSFEISVTDKSLECPSlvVKHYHFLKWRDHTAPMTSI
.||| |..  .. ..|..        .|||.| | . .| .  .  ... ...        .....|.|   |  .  .  .. .||| | |.  |  ..
adfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirk..itqfhflGwpdvGvpdyps

SVLKLLKALR----DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGvpQNDNMLDL
 ...|.| .|      . . . |.|||||.||| . | .|   .|. |   ..| ..||..|| |.. ||.  |. |. . . .  ..     .  | |.
dlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh..sdvampdf

ADFYTEFM
  .. |  
payleels
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 143-370 3.9e-39 129.1 In-house 56-282 (305) alignment 
Range on Protein: 143-370
Range on HMM: 56-282/305.0
SEKCRYYDILCPDATRVVLqNRPPDNDFIHANWMTMP---DKfRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSED-NISHVC
  | || |. | | . | | ..|.  |.||||..  |   .| |.| ||||.|||...|| ||  .|   .||.|   | |  ||..| |    .  .. 
itknryqdvpcqdqsavkl.dkpspsdyihanyvgcpmipek.rficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

GIYRITKIDQMTMVYADVALQSFEISVTDKSleCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRpgPPVIHCSAGIGRTATLIGVDYGNQRIG
.   . ..     .  |  .|   . .|       .. |.| .. .| |   |   .. |.|| |.|  |   | |.||||||||| |.. ..|  ..| 
sgivvenvsgskpmerdaeiqitllnltysg..dqkmsvrhlqwtewpdrgvppckltslellsairgskv..pivvhcsagigrtgtivaieyilekia

EVGEMN-VLDIVREMRQMRDKAVQSHHQFIFML
|  .   . ..|. .|. |  ..|.  |..|. 
enkpcppmpelvkalrdqrafsiqndvqylfih
0041856 (Phosphotyrosine protein) phosphatases II 144-378 4e-39 129.4 In-house 3-172 (182) alignment 
Range on Protein: 144-378
Range on HMM: 3-172/182.0
EKCRYYDILCPDATRvvlqnrppDNDFIHANWMTMPDKF-RYISAQGPMDQTVEDFWHMVYTEKAPAVVMICdweedgiqkCSRYIPsednishvcgiyr
.| ||.|||..| .|        |.|.|.||.. .. .. |.| .|||...||.||..|.. ..  ..|...         . .| |             
dknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

itkidqmtmvyadvalqsfeisvtdkslECPSLVVKHYHFLKWRDHTAPMtSISVLKLLKALRDpkRPGPPVIHCSAGIGRTATLIGVDYGNQRigevgE
                            |     . .|..| | ||..|    ..|..... ..  ..|| ..|||||.|||.||.. ..  ..     .
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....g

MNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
... ..|...|..| ..|.. .|..|  ... ... 
vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 139-399 8.2e-39 128.8 In-house 22-275 (284) alignment 
Range on Protein: 139-399
Range on HMM: 22-275/284.0
MKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICdweedgIQKCSRYIPSEDNIS
...  .| |. .||  | ..| |..       |.| | ..|    | .||..|||.| |..||| |..  .. ..|..        .|||.| | . .| 
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

HVCGIYRITKIDQMTMvyadVALQSFEISVTDKSLECPSlvVKHYHFLKWRDHTAPMTSISVLKLLKALR----DPKRPGPPVIHCSAGIGRTATLIGVD
.  .  ... ...        .....|.|   |  .  .  .. .||| | |.  |  .. ...|.| .|      . . . |.|||||.||| . | .|
eerfkvkvdsveesee....yvvrdielsedgkekdirk..irqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

YGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGvpQNDNMLDLADFYTEFM
   .|. |   ..| ..||..|| |.. ||.  |. |. . . .  ..     .  . |.. .. |  
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh..sdvalpdfpayleels
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 140-377 1.8e-38 127.2 In-house 42-277 (315) alignment 
Range on Protein: 140-377
Range on HMM: 42-277/315.0
KKHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
.   .| || .||  | .||.|   .  ||.|.| |  .   |.   ||..||| . .|.|||.||. ||. ..||. . .|.   || .| | ..  | 
tinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

VCGIYRITKIDQMTMvyADVALQSFeisVTDKSLEcpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK--RPGPPVIHCSAGIGRTATLIGVDYGN
  | .... ..  .   .|   . .   || || |  |  |  ..| .| |. ..  . |.|||.|...  .  .  . ..|||||.|||  .| .|   
efGsikvellslead..tdgvarkl...vtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

QRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
..| .   ..|...|...|. | . ||.. .. |.   . . .
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 143-376 2e-37 123.5 In-house 44-275 (515) alignment 
Range on Protein: 143-376
Range on HMM: 44-275/515.0
SEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCG
 .| || .||  | .|| |   |  |..|.. |  .   |    ||..||| . .|.|||..|. |.  ...|. . .|.   ||..| |     |   |
fkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

IYRITKIDQMtmVYADVALQSFEISVTDKslecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTATLIGVDYGNQRI
 ...  .       ..   . ...   |.     |  |  .|| .| |. .|  . |.|||.|...    .   | .||||||.|||  .| .|    ..
sikvelvsle..actggikrkltvlkgdd.....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
 .   ..|...|. .|| | . || . |. |.   . . 
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 134-374 3.9e-37 122.4 In-house 29-266 (281) alignment 
Range on Protein: 134-374
Range on HMM: 29-266/281.0
CVADTMKKHSEKCRYYDILCPDATRVVLQNRPPD---NDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
| .       .| || .| | | .|| |. . |.    |.||||..  |  |  || .|||  .|  |||.|.. |.. |.||.|.. |   .||. |.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

SEdniSHVCgiyriTKIDQMTMVYADVALQ-SFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDpkRPGPPVIHCSAGIGRTATLI
 .   .|.|      ..|.... | | ... |.  .  . | |  . .. |. . .| |   | .|  .||.|. .|   |  |||||||||.||. ||.
rn...ahcc.....lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira..rstppvihcsagvgrsgtlm

GVDYGNQRIGEV-GEMNVLDIVREMRQM-RDKAVQSHHQFIFMLMCIA
 |.   | |       .. .||  .|   |  .||. .|....   . 
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 132-370 4.3e-37 122.5 In-house 23-259 (283) alignment 
Range on Protein: 132-370
Range on HMM: 23-259/283.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRPPdnDFIHANWMT----MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
  .. .. ... .| |. .|.  |  || |.. ..  |.| | ...      .. .|| ||.|.|.|| |||.||. ||. |.||.    ||  .|||.|
ldadiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqy

IPSEDNISHvcGIYRITKIDQMTMvyADVALQsfEISVTDKSLECPSLVVKHYHFLKWRDH--TAPMTSISVLKLLKALRDPKRPGPPVIHCSAGIGRTA
 |..  . .  | . .|  ...|        .  |. .  .|    .|.. || .  | .    |.. |.  . ....|.  .. || |.|||.||||||
WPkrGsedy..Geftvtlrketts..nsfiik..elllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrta

TLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
..|..    . .     ..|  .|. ||. |  |||.  |. .. 
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 136-379 5.3e-36 119.1 In-house 37-273 (288) alignment 
Range on Protein: 136-379
Range on HMM: 37-273/288.0
ADTMKKHSEKCRYYDILCPDATRVVLQnrpPDNDF-IHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdn
.|.  . . . || .. . |.||| |.    | || |.|| ..  . | | | || |.. |.| .|.|. ..    .||.|.  | | .|   | ||.  
idsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk..

ISHVCGIYRITKIDQMTMvyADVAlQSFEISVTDKSLECP--SlVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRpgPPVIHCSAGIGRTATLIGVD
. .   | |. .. .     ||.  .  ..|.   | |      .||. |.|.| |.. |   .| |.||. |.. ..  | |.|.|||.|||.||| . 
lGekarigrlctvvkkkr..adid.klvkvsllriskegeekv.ivkilhlleWdddgvPenylsplrllevlkslqk..PivvhssaGvGrtgtlilil

YGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVL
   . .  .  . .  .. ..|. | ||.|.  |....  |. . ..|
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 140-374 1.1e-35 117.8 In-house 36-274 (287) alignment 
Range on Protein: 140-374
Range on HMM: 36-274/287.0
KKHSEKCRYYDILCPDATRVVLQNRPP-DNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdNISHV
    .| || |.|  | |||.| . .    |.| ||...   |. ..|.||||.  || ||| .|. ... .|...    |.. .|| .| |   .    
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

CGIYRITKIDQmTMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSIS-------VLKLLKALRDPKRPGPPVIHCSAGIGRTATLIGV
 | | .. .|. ..   . . ... .   .      . ||| ...|.| |.... |...       | . ... || .  ||.|.|...||||. .|. .
vGGysvvlldy.dikePeygvralrlidletr...earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat

DYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA
    .|  ..|...|  .|  .|. |   ||.  |. ..   ..
lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_PTPN23_pd Subfamily PTPN23 139-371 3.5e-35 116.2 In-house 40-274 (288) alignment 
Range on Protein: 139-371
Range on HMM: 40-274/288.0
MKKHSEKCRYYDILCPDATRVVLQnrPPDNDFIHANWMT--MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISH
 |..||| |. |||  | .||.|.     .|.| | ..    |    .| .|.|...|. ||| ||| .|.. .||. . || | .|..|| |.. . ..
aklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetv

VCGIYRITKIDQMTMVYadVALQSFEISVTDKSLecpSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD----P--KRPGPPVIHCSAGIGRTATLIGV
. | ...|  .. .. .  .  . ..... |..       |.| .. .| .. .| .  ..|..|.. ..       |   | |.|||||.||| ..  |
kfgdlsvtlksvretet..hvervlkletldada...vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

dYGN-QRIgEVGE--MNVLDIVREMRQMRDKAVQSHHQFIFMLM
 |.  . . |.|.  ......|. .|. |   || ..|. |.. 
.yaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsye
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 141-377 5e-35 115.9 In-house 48-279 (315) alignment 
Range on Protein: 141-377
Range on HMM: 48-279/315.0
KHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEdniSHV
.  .| ||..|.  | .|| |   .  |. |.. ||..     | |||.||||  ..|.||| .|. |.   .||. .  |.  .|. .| | .     .
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kvi

CGIYRITKIDQmtMVYADVALQSFeiSVTDKS--LEcpslvVKHYHFLKWRDHTAPMTSISVLKLLKALRD--PKRPGPPVIHCSAGIGRTATLIGVDYG
 | . .|....   |. ... ...  ||. ..   |     |  .|.  | |   |  .|....| .  .    .  |. |.|||||.||| |.| .|  
yGkitvtrkse..evnteytvrtl..svvfgdnire.....vvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldav

NQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
 ...     ..| .... .||.| |.||. .|. |.   . . .
ldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPRN_pd Subfamily PTPRN 130-376 1.3e-34 114.2 In-house 44-291 (297) alignment 
Range on Protein: 130-376
Range on HMM: 44-291/297.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM--PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCS
 |||. .   .|  .| |. ..|  | .|| |...    ..|.| |  ..   | .  ||..|||. .|| ||| ||. . .  .|...  ||.|...|.
epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqck

RYIPSEDniSHVCGIYRITKIDQMtMVYADVALQSFEISVTDKSlecPSLVVKHYHFLKWRDHTAPMTSISVLKLL----KALRDpkRPGPPVIHCSAGI
|| | |   |.| .|| .  . .  .   |  ..|| .   ..|    .  |  .||| |.....| .. |.|..     |. |   |  | |.|||.| 
rywpdeG..sevyhiyevhlvseh.iwcddylvrsfylknlqts...etrtvtqfhflswpeegvPasaksllefrrkvnksyrG..rscpivvhcsdGa

GRTATLIGVDYGNQRIG-EVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
||| . | .|   .|.   | |...   .  .|. |.. |....|| |.|...|. 
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee
0051429 (Phosphotyrosine protein) phosphatases II 167-377 1.8e-34 115.0 In-house 3-225 (272) alignment 
Range on Protein: 167-377
Range on HMM: 3-225/272.0
DNDFIHANWMTMPdkFR------YISAQGPMDQTVEDFWHMvYTEKAPAVVMICDWEEDGIQKCSRYIP--------SEDNISHVCGIYRITKIDQMTMV
 .. |.|... ..  .|      .. ..||.. |..|||.. ....  ..|.... || | .||.||.|         .|.      ..... . .....
lsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

YADVALQSFEISVTDKSLECpsLVVKHYHFLKWRDHTAPMTSisVLKLLKALRDpkrPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMN--------
. |. |  .... . .  |   . | |.|.. | || .|  .  .|.||..|.|   .|| ..|||||..||.|.. ...  .....   ..        
lldyilrellltlllsagea..revmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

VLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
....|.|.|..| .|||. .|..| ...... .
leeaveelraqrpgavqteeqylflyeallell
0043147 (Phosphotyrosine protein) phosphatases II 166-370 5.1e-34 112.9 In-house 3-154 (172) alignment 
Range on Protein: 166-370
Range on HMM: 3-154/172.0
PDNDFIHANWMTMPDKF-RYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWeedgiqkcsryipsednishvcgiyritkidqmtmvyadvalqsfeis
...|.|.|... .. .  |.|  |||.. |..|||.|.....  ..|.....                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

vtDKSLECPSLVVKHYHFLKWRDHTAPmTSISVLKLLKALRD---PKRPGPPVIHCSAGIGRTATLIGVDYGNqrigevGEMNVLDIVREMRQMRDKAVQ
   .  |. .  . .|..| | ||..| ..  .|..|. ...    .. || ..|||||.|||.||.  ..          ......|...|..| .|||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

SHHQFIFML
. .| .| .
npsqyrfly
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 127-414 1.9e-33 110.8 In-house 12-282 (290) alignment 
Range on Protein: 127-414
Range on HMM: 12-282/290.0
AlrapstcvADTMKKHSEKCRYYDILCPdATRVVLQNR--PPDNDFIHANWMTMPDKFRYISAQGPMDQT-------VEDFWHMVYTEKAPAVVMICDWE
         .| .|||. . |.   |   ||||||..      .|.|||| .|.|.  | |  | |  ..       .|.|| |.  ||.  |||.|. |
k........tdyvkkhemdqRlevpLve.atrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefe

EDGIQ----KCSRYIPSEDN-ISHVCGIyRITKidqMTMV-YADVALQSFEISVTDKslecPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRdpKRPG
|   .     |..|.| . . .  . |.  .       ..   ||     ..   |.      . |.|. .  | .  .. .....|.|.. ..  ..  
eksantslfaCakYvpesvgeelkfkgl.tvkC...kskekeddvetRelvvkfdde....eeftvtHsllkgWnklnvqedtktllsliqkvk..askt

PPVIHCSAGIGRTATLIGVDYGNQRIG-EVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAdrmvldgvpqndnmLDLADFYTEFMKKVLMERKKKD
| ..||  || | |.|  .. | | |    |.... |.. ..|..|..|..|.... |..  |               | . ... .|...   .. |..
pvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv..............llaievldqfaeeetekkakae

EAEK
| | 
eket
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 144-373 8.2e-33 108.6 In-house 5-235 (237) alignment 
Range on Protein: 144-373
Range on HMM: 5-235/237.0
EKCRYYDILCPDATRVVLQNRPPDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNiSHVCGIY
 | || .| . | .||||.    . |.| |...   |    .||.||||.. . .||| ||. ||   .||.    |   .|| .| || |.     |..
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paaygvl

RITKIDQmtMVYADVALQSFEISVTDKSLECpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK----RPGPPVIHCSAGIGRTATLIGVDYGNQRI
 ..   .    ..| ...|. .|.  .  |    ... |.|  | |.  |  . ..|.. | . .      . || .||||||.|||. .. .|   .. 
tvslkkk..eefsdytvrslllskrltlkev..rlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
 |   ... . |  . . |   .|.. |..|.   |
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
0046846 (Phosphotyrosine protein) phosphatases II 158-372 2e-32 107.8 In-house 2-168 (176) alignment 
Range on Protein: 158-372
Range on HMM: 2-168/176.0
RVVLQNRPPDNDFIHANWMTMPdkfRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHvcgiyritkidqmtmvyadva
|..|   ..| |.|.||.. ..   |.|  |||. .|..||..|.. ..  |||..... | |  || .| | . . ..                     
rlrllgldldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

lqsfeisvtdkslecpslvvkHYHFLKWRDHTAPMTsISVLKLLKALRDPKRPG-PPVIHCSAGIGRTATLIGVDygnqrIGEV-GEMNVLDIVREMRQM
                     .|..| |.||..|     .|.||...|.  . | | ..|||||||||.||.  .     . |    ..|.......|..
.....................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreq

RD-KAVQSHHQFIFMLMC
|  .|||. .|  |  ..
RplgavqtpeQyrflyef
0049260 (Phosphotyrosine protein) phosphatases II 181-370 2.1e-32 107.3 In-house 8-143 (152) alignment 
Range on Protein: 181-370
Range on HMM: 8-143/152.0
KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIpsednishvcgiyritkidqmtmvyadvalqsfeisvtdkslecpslvvkHY
.|..| .|||...|..|||.|... .. ..||.....|.|  || .||                                                  .|
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................qy

HFLKWRDHTAPMTSISVLKLLKALRD--PKRPGPPVIHCSAGIGRTATLIGVDYGNqrigevGEMNVLDIVREMRQMRDKAVQSHHQFIFML
..| | ||..|  |. .| ||....    .. || ..|||||.|||.||.  ..          ......|. .|..| .||....| .| .
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 130-379 6.3e-32 105.6 In-house 34-281 (439) alignment 
Range on Protein: 130-379
Range on HMM: 34-281/439.0
APSTCVADTMKKHSE--KCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIqkc
 . .|.|  . .. .  | || |.   | |||.||. |  |   .| ||..    |.  ||..||| ..|..||| .|. .|.  .||...  |      
pdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...

srYIPSEDNISHVCGIYRitkIDQmTMVYADVALQSFEISVTDKSLECpSLVVKHYHFLKWRDHTAPMTSISVLKLLKAL---RDPKRPGPPVIHCSAGI
  | ||.... .   . |   .|.  .   . ... | .     . |     | ..|.. | |.  |  .  ||..|.|.    | .  || |.|||||.
..ywpsdaevcygdiavr...vdr.nielpnyvirgfkvfnerdttek.ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagv

GRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVL
||| |.| .|   ...    ....  ||. .|. | . ||.  |..|.  .. . .| 
GrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 131-370 1e-31 104.6 In-house 41-283 (310) alignment 
Range on Protein: 131-370
Range on HMM: 41-283/310.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQ-NRPPDNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYI
 |.   ...||.  | || |..| |..|| |. ..   .|.||||..     .  .| .|||...|. ||| |.. |.| .....|   |.|  ||  | 
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PSEdNISHVCGIYRITKID----QMTMVYADVALQSFEISVTDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKllKALRDPKRPGPPVIHCSAGIGRT
||   ..   |  |.|..     .. ..   |..   .. | ..  .   | |.  .. .| |   |      .   . |    | || |.|||||..|.
psl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaqvrhgpcvvhcsagkdrl

ATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFML
 ... ...  ... .  .... ... |... | . .|.. |.... 
yvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
0049772 (Phosphotyrosine protein) phosphatases II 133-375 1.3e-31 105.9 In-house 37-278 (314) alignment 
Range on Protein: 133-375
Range on HMM: 37-278/314.0
TCVADTMKKHSEKCRYYDILCPDaTRVVLQNRPP-DNDFIHANWMTMPdkFRYISAQGPMDQTVEDF----------WHMV--YTEKAPAVVM-------
|...    .. .| ||.|||. | .||.|.. |  . |.|.|...  .   ..| .|||.. ||.||          |.||  .  .   .||       
tilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

--------------ICDWEEDGiqkcsryipsedNISHVCGIYRITkidqmtmvyadvalqsfeiSVTDKSLECPSLVVKHYHFlKWRDHTAPmTSISVL
              ...  . |            |. ... .  .                    ....    .. |..|....  . |..|| ..  ..
delsrLdaAlgKtpllildgng............neptaadlellk...................eelydpelferlgikylri.pvpDgsap.lledfd

KLLKALRDPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGevgeMNVLDIVREMRQMRD-----KAVQSHHQFIFMLMCIAD
..|..... ...|| ..||.||.|||.|.. ..|   . |    ... ......|..|       ....  |..|.|... .
eflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 132-409 1.9e-31 103.9 In-house 35-307 (312) alignment 
Range on Protein: 132-409
Range on HMM: 35-307/312.0
STCVAdtMKKHSEKCRYYDILCPDATRVVLQNrpPDNDFIHANWMTMPDKFR-YISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPS
| | |  . |  .  || .| | |  |  |     .| .||||.. .  |   ....|||...|.  ||... .  . .....| . ||| .||..||  
secta..flkfkdlnrypniqcwdrgrftlag..denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd

EDN----ISHVCGIYRITKIDQMTMVYADVALQSFEISVTDKSLECpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPgpPVIHCSAGIGRTAT
         |       |.|.        .. . . . |     |     ..|| .  | ||  | .  . |.|| |..  |.|   . |||||.||| |
ivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqes...klnhyqwaswpdhgmpdscdtalrllsavkkdkkp..viahcsagvgrtgt

LIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGVPQNdNMLDLADFYTEFMKKVLMERKKK
|. ..     .      || |.   .|. | ..|.   |... | |. . .   |. .  |  . . |   . |    . | |
laliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykr.neqewtkfketyakikakklkik
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 139-378 9.7e-31 102.1 In-house 45-289 (325) alignment 
Range on Protein: 139-378
Range on HMM: 45-289/325.0
MKKHSEKCRYYDILCPDATRVVLQNR--PPDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWeEDGIQKCSRYIPSEDNIS
  .  .| |. ...  | .||||. .   |. |.| |...    .|  ...|| |. .|..|.| .|.  ... ||..    . | ..|. | | |   |
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgks

HVCGIYRITKIDQMTMvyADVALQSFEISVTDKSlecPSLVVKHYHFLKWRD---HTAPMTSISVLKLLKALRDPKR-----PGPPVIHCSAGIGRTATL
   |  ..  .   ..  .|   . ...  ..|     .. || ...  | |   .  | | ||.|.|.||. .  .      .| ..|||||.||| ..
ktfGglevklrtieei..sdyvhrvldvkqvkkG...etrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvf

IGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMV
| .    ... |  ...... |. .|. | . |..  |.|..  .... ..
islysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
0036282 (Phosphotyrosine protein) phosphatases II 169-369 1.7e-30 101.4 In-house 3-162 (174) alignment 
Range on Protein: 169-369
Range on HMM: 3-162/174.0
DFIHANWMTMPD--KfRYISAQGPMDqtvedFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSednishvcgiyritkidqmtmvyadvalqsfeisvt
|.|.|... .    . |.|  |||..     ||.|.. ..  .||| ....|.|. || .| |.                                    
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

dkSLECPSLVVKHYHFLKWRDHTAPMTSIsVLKLLKALRDP---KRPGPPVIHCSAGIGRTATLIGVDYGNQRIGeVGEMNVLDIVREMRQMRDKAVQSH
    | ..  . .|..| | ||..| .|| .|...|....    .. || ..|||||.|||.||.. ..  ...   . ...||.|||.|..| ..||. 
..lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

HQFIFM
.|..| 
sQyrfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 141-292 2.3e-30 100.5 In-house 30-181 (297) alignment 
Range on Protein: 141-292
Range on HMM: 30-181/297.0
KHS--EKCRYYDILCPDATRVVLQNRPPDNDFIHANWMTMPD---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNIS
. |   | || |||  | ||| |.. ....|.| |.....||   ...|| ||||...||.|||..|. .   ..||..  .||| .||  | || ..  
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

HVCGIYRITKIDQMTMVYADVALqsFEISVTDKsleCPSLVVKHYHFLKWRDHTAPM
  .| . .  . ...  .  | |   |. .  .     | ||.|  || | ||  | 
lkagdvvveflsstsdefdrvil..telqliyr...sesrvvrhvqflswpdhGvps
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 143-373 2.3e-30 100.5 In-house 8-236 (239) alignment 
Range on Protein: 143-373
Range on HMM: 8-236/239.0
SEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPseDNISHVC
  | || .|.  | .||||..    | .|.| |...   |     ||..|| .  .  |||.|.. |.   .||.    |   .|| .| |  |. |. |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskyc

GIyRITKidQMTMVYADVALQSFEISVTDKSLECpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPG--PPVIHCSAGIGRTATLIGVDYGNQR
 . |.|   . | |.||  ...| .|   .. |     | .|||  | |.  |  . .|| | . .     ||  | |||||||.||| ... .|   ..
nl.rvtl..rktevfadyiirtfvmsqvgqteer...yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
  .   ..... |. .|. | . ||.  |..|. ...
akkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 143-373 2.4e-30 100.4 In-house 9-237 (239) alignment 
Range on Protein: 143-373
Range on HMM: 9-237/239.0
SEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPseDNISHVC
  | || .|.  | .||||..    | .|.| |...   |     ||..|| .  .  |||.|.. |.   .||.    |   .|| .| |  |. |. |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp..dstskyc

GIyRITKidQMTMVYADVALQSFEISVTDKSLECpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPG--PPVIHCSAGIGRTATLIGVDYGNQR
 . |.|   . | |.||  ...| .|   .. |     | .|||  | |.  |  . .|| | . .     ||  | |||||||.||| ... .|   ..
nl.rvtl..rktevfadyiirtfvmsqvgqteer...yvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

IGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
  .   ..... |. .|. | . ||.  |..|. ...
akkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN14_pd Subfamily PTPN14 130-372 2.7e-30 100.4 In-house 37-291 (300) alignment 
Range on Protein: 130-372
Range on HMM: 37-291/300.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQ-NRPPDNDFIHANWMTMP---DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCS
. ... . ....  || |. |.|  . .|| |. ..  ....| |  . ..    .  || ||||...||.|||.||. ..   .||. . |||| .|. 
edallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

RYIPSE-DNISHV-CGIYRIT-KIDQMTMVYADVALQSFEISvTDKSlecpsLVVKHYHFLKWRDHTAPMTS---ISVLKLLKALR-------DPKRPGP
.|.|.. .. ..|  | ...| |  . .  ..  .|.   .  . .        | |  .  | ||  |      .| |. ....|       ..|   |
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlp.skee.....rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

P-VIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMC
| ..|||||.|||  || .|   . .    |...  ... .|. |.  ||.  |. |.   
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 125-376 2.3e-29 97.0 In-house 26-235 (392) alignment 
Range on Protein: 125-376
Range on HMM: 26-235/392.0
FVALRAPSTCVADTMK--KHSEKCRYYDILCPDATRVVL--QNRPPDNDFIHANWMTMPDK-FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEED
|  |  |      . .     .| || .||  |..||.|   .  ||.|.. | ..   |    ||..|||   ...|||.||. |.. ...|. . .| 
fhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkeg

GiqkcsryipsednishvcgiyritkidqmtmvyadvalqsfeisvtdKSLECPSlvVKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHC
                                                |  .. .  |  .|| .| |.  |  . |.||..| ..    .   | .|||
d...............................................kgddart..vaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihc

SAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADR
|||.|||. .| .|    .  ..  ..|...| ..|. |   ||.. |. |.  .. . 
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 194-391 5.8e-29 95.9 In-house 40-231 (255) alignment 
Range on Protein: 194-391
Range on HMM: 40-231/255.0
TVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDqmtmVYADVALQSFEISVTDKSlECPSLVVKHYHFLKWRDHTAPMT
||. |....   |.  |||.||..|.|..|||.|.| | .   .     .|  .      ||| |.  ||  |          ||||..  | .. ||  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlge.kkkthtvkhysykGWieknaPel

SISVLKLLKALRDPKrpgPPVIHCSAGIGRTATLIGVDYGNQ------RIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMvldgVPQNDN
.  .|..||. || |   . |.|||.||||.|... ...  |      .  | .|.. | ...|.|..| .|..   |. | .. . | .     |... 
areilnilkvvrdsk...svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv....fpkgel

MLDL
  ..
eaky
subfamily_CG7180_pd Subfamily CG7180 131-371 6.1e-29 95.6 In-house 31-284 (296) alignment 
Range on Protein: 131-371
Range on HMM: 31-284/296.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEeDGIQKCSRY
  .| ..  |.  || |. ... .| .||||..     ..|.| | ..  .  |  ||  ..|...||..|| .|| |.. |||....   |  ...  |
igdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktf.dfakmypsy

IPSEDNISHVCGIYRITKIDQMT-MVYADVALQSF--EISVTDKSLECPSLVVKHYHFLKWRD-HTAPMTSISVLKLLKA---LRDPK----RPGPPVIH
.| . .  .   .  |.. .|.. ..   . |.     .. ..|  . .  .||.... .|   .  |. . ....|..    .|.        || |..
wpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLM
.| | .|.   ...|   . . . .|..| . |. .|. | . |.. ... ..  
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd
PTPc_DSPc_SM00012 277-374 8.1e-29 95.3 In-house 2-104 (105) alignment 
Range on Protein: 277-374
Range on HMM: 2-104/105.0
VKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRP----GPPVIHCSAGIGRTATLIGVDYGNQRIGEV-GEMNVLDIVREMRQMRDKAVQSHHQFIFMLM
|||||...| || .| .| |.|.||.|... |.     .| |.|||||.|||.|.. .|.  |.. .  .|.....||.|.|..| ..||. .|..|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CIA
...
all
subfamily_hpo-7_pd Subfamily hpo-7 191-406 8.3e-29 95.3 In-house 43-251 (263) alignment 
Range on Protein: 191-406
Range on HMM: 43-251/263.0
MDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITkidqMTMVYADVALQSFEISVTDKSlECPSLVVKHYHFLKWRDHTA
. ||.. |....   |.  |||.||..|.|..|||.| | | .   .     ..     | |  || |.. |.  | .        |||| .  | .. .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc....ttkvqsdvllktlellstlge.KkkthtvkhysykgWieknd

PMTSISVLKLLKALRDPKrpgPPVIHCSAGIGRTATLIGVDYGNQ------RIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMciadrMVLDGVPQ
|. ....|..||. |. |   . |.|||.||||.|    ..   |      .  . .|.. | ...|.|..| .|..   |. | ..     |||| | .
pelareilnilkvarnsk...slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil.....mvLdfvln

NDNMLDLADFYTEFMKKVLMER
|    .|   | |  |  |  |
nfakgeleakyqeirksylhar
0051082 (Phosphotyrosine protein) phosphatases II 167-373 3e-28 93.7 In-house 2-149 (151) alignment 
Range on Protein: 167-373
Range on HMM: 2-149/151.0
DNDFIHANWMTmPDkfrYISAQGPMDqtveDFWHMVYTEKAPAVVMICDWEEDGiqKCSRYIPSEDnishvcgiyritkidqmtmvyadvalqsfeisvt
 .|.|.....| .    ..  .||..    ||. ......  ..|.... || |  .| .| |...                                  
lsdyinfsyvt.gg...lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

dkslecpsLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDpKRPGPPVIHCSAGIGRTATLIGVDYGNQRigevgeMNVLDIVREMRQMRDKAVQSHHQF
        . |.|...| | |.. |..  .||..|..|.| |..|| ..|||||.|||.||....   ..      ... ....|.|..|  .||.. ||
........ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

IFMLMCI
.| |...
lfqlfal
0044763 (Phosphotyrosine protein) phosphatases II 155-371 3.7e-28 93.8 In-house 3-165 (178) alignment 
Range on Protein: 155-371
Range on HMM: 3-165/178.0
DATRVVLQNRPP--DNDFIHANWMTmpdKFRYISAQGPmdqtvEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNishvcgiyritkidqmtmv
| |||.|.|..     |.|.|....    . |.....|     .|.. ... ..  ..|....  | | .|| .| |.| .                   
drtrvllsnleglersdyinaseil...pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...................

yadvalqsfeisvtdkslecpslvvKHYHFLKWRDHTAPMTSISVLKLLKALRDP--KRPGPPVIHCSAGIGRTATLIGVDYGNQRigevgEMNVLDIVR
                          .|... . ||..|  .  .|........   ...|| ..|||||.||..||.  ..  ..      ... ....
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

EMRQMRDkAVQSHHQFIFMLM
..|..|  .|.. .|  ....
lvrerRp.ivpnpgqlrqLye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 138-377 4.2e-28 92.7 In-house 33-288 (302) alignment 
Range on Protein: 138-377
Range on HMM: 33-288/302.0
TMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMTMpDKFRYISAQGPMDQ-----------------TVEDFWHMVYTEKAPAVVMICDWEEDG
 ..|.  . |    .|   |  .|..   .|||| || ... |. ..| ||||||                  |.| .| ..   .   || .|.  ||.
nlekdiserrkslficepktmaklvdf..kndfinanvlkl.deikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvede

IQKCSRYIPSEDNISHVCGIYRITKIDQMTMVY--A---DVALQSFEISVtDKSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPgpPVI
 .||. |   . .     | | .. ..  | .   .   .. | . ||   .|  .     |.  .|  | || ||  . . |..||     |.    ..
ekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveikn.ekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykkn..vlv

HCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
|||||.||| ||. . || |   .    ..|.||  .|| |  |||...| |..|.|..  .
hcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkgl
subfamily_egg_pd Subfamily egg 140-378 4.8e-27 89.4 In-house 38-273 (307) alignment 
Range on Protein: 140-378
Range on HMM: 38-273/307.0
KKHSEKCRYYDILCPDATRVVLQNRPP--DNDFIHANWMTM-PDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDgiQKCSRYIPSEDNISH
. . ||.|   . | | .|| |. |     .|||||| .   |    .| || |.  ||.||| ||. |. . .||.    |   ..|  | |  .. | 
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdsl

VC--GIYRITKIDQMTMvyADVALQSFEISVTDKSleCPSLVVKHYHFlkwrDHTAPMTSISVLKLLKALRDPKRpgPPVIHCSAGIGRTATLIGVDYGN
|   | .||. ..      ||  ..  .. .         . ..|.      |        | |..|. ||.  .  | |...  |. ..|||. ..   
vtvpGslrienlkvdsk..adplfrvtklklvGgd..deerflehwqg....dvnnssdvysplrvlrklrnlsk..pvvvqdilGvskaatlvaieial

QRI--GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIA--DRMV
  .  | .    ||  |  .|. |  .|.|  ...|.   ..   | |
lsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 132-377 1.1e-26 88.2 In-house 30-293 (301) alignment 
Range on Protein: 132-377
Range on HMM: 30-293/301.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRPP----DNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 .|.  . .....  |. .|   |  |..|.. |      ...| |...  . .| ..| |||||..|. |||.... ||  ..||... .|.  .|| .
ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceq

YIPSEDNISHVCGIYRITKIDQMtmVYADVALQSFEISVTDKSL------------ECPSLVVKHYHFLKWRDHTA---PMTSISVLKLLKALRDPKRPG
| |. .. |.  |   .| ....  || |  .... . ..| |             .  |  |  ..  .| ..     | | . |.      .     |
ywpnseaeseefgpftvtlvneq..vyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkiggg

PPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRM
| |.|||....|. . . |. |       |  .| .... .|. . .||.   |....   |   .
pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 132-375 2.4e-21 71.0 In-house 23-257 (267) alignment 
Range on Protein: 132-375
Range on HMM: 23-257/267.0
STCVADTMKKHSEKCRYYDILCPDATRVVLQNRppDNDFIHANWMT-MPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCsrYIPS
||.     .|  |. |. | |  | |||.|...  ....| | ..     |  .|  |.|...|. ||. ..  .| | .|..    .| |..   . | 
stisqsiaeknqernrlddnlpyddtrvilrtk..eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlf..wPPk

EDNISHvcgIYRITKIDQMTMVYADVALQSFEISVTDKSLEcpslVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPKRPGPP-VIHCSAGIGRTATLIG
  .  .      .|    .     |  . ..|. . ..|       |  |.. ||   |     .  |  . |  . .  ..| |..||.|.||. |.. 
mgqakk...yqdltvehslekeendyqiitlelkfknesah....nvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflv

VDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD
.|   .|. . | ... | .|..|. |   |..  ..|..   .|.
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 112-373 3.6e-21 69.9 In-house 19-281 (302) alignment 
Range on Protein: 112-373
Range on HMM: 19-281/302.0
FVDELDCKKLMRDFVALRAPSTCV--ADTMKKHSEKCRYYDILCPDATRVVLQNRPpdNDFIHANWMTMPDKFR-YISAQGPMDQTV---EDFWHMVYTE
.|..||  .. ..| .. .  . .    . ||...|..  |. ..|...| |...|  .....|  ...|.  |  | || |  ...   |.||.||. |
lvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep..dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

KAPAVVMICDWEEDGIqKCSRYIPSEDNISHVCGIYR--ITKIDQMTmvyADValQSFEISVTDKSLeCPSLVVKHYHFLKWRDHTAPMTSISVLKLLKA
|   ||..   ||      | ..| . .  .  |  .  . |....    ...  . . | |  .     |.... |..  |.... |.   .. |  . 
kivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekae...eek..tryviEvlPegc.snsvlanvyvltnWkqkkvpvkyaeliktaak

L--RDPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
.  .. |   . ||    |.|| .... .    ... .  | |. .||. .|. | .||.| .|.... ...
vfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 144-373 2e-20 67.8 In-house 49-340 (350) alignment 
Range on Protein: 144-373
Range on HMM: 49-340/350.0
EKCRYYDILCPDATRVVLQ--NRPP--------DNDFIHANWMTMP-------DKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSR
 | || .||  . .|| |.   ...         ||.| ||.. ..        .|.||..|.|. .||.||.....  | . .... .  | ...|| |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YIPSEDNISH----VCGIYRITKIDQMTMVYADVALQSF-------------EISVTD-KSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLK------
| .  .   .          |. |.....  |||  ..              . |.|. .   .  .|| . .. .|.| .  .  .|.|. |.      
YWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndli

------ALRDPKRPGPPVIHCSAGIGRTATLIGVDYGNQ----------RIGEVGEM-----NVLDIVREMRQMRDKAVQSHHQFIFMLMCI
         | .|  | ..|||||.||| ||. .|.  .          .  ..  .      .  || |.|. | . ||. .||||.  ..
ddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeal
0048076 (Phosphotyrosine protein) phosphatases II 271-373 1.9e-19 65.2 In-house 41-139 (145) alignment 
Range on Protein: 271-373
Range on HMM: 41-139/145.0
ECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP-KRPGPPVIHCSAGIGRTATLIGVDYGNQrigevGEMNVLDIVREMRQMRDKAVQSHHQFIFM
| ..  . .|..| | ||..|  .  .|..|.....  |..|| ..|||||.|||.||.. .   .       ... ......|..| .||.. .|..|.
ellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

LMCI
....
yefe
subfamily_ptpA1_pd Subfamily ptpA1 130-328 9.7e-19 62.4 In-house 35-247 (418) alignment 
Range on Protein: 130-328
Range on HMM: 35-247/418.0
APSTCVADTMKKHSEKCRYYDILCPDATRVVLQNRP--PDNDFIHANWMTMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRY
 ||       |. . | || .||  . ||| |..      .|.| ||..      ..| .|||. .|. |||.||. ...  .||.    |.   || ||
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdry

IPSEDNiSHVCGIYRITKIDQMT-MVYADVALQSFEISVTD----KSLECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRD--------PKRPGPPV
 | .        ||   .    |  |     .|  |  .       ..|  .  . .|..  | ||  |  .  . .||... .          |  | .
wpeqig.geqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

IHCSAGIGRTATLI
.|||||.||| |. 
vhcsagvgrtgtfc
0048179 (Phosphotyrosine protein) phosphatases II 271-371 1.6e-18 62.3 In-house 43-139 (144) alignment 
Range on Protein: 271-371
Range on HMM: 43-139/144.0
ECPSLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDP-KRPGPPVIHCSAGIGRTATLIGVDYGNqrigeVGEMNVLDIVREMRQMRDKAVQSHHQFIFM
|..   . .|..| | || .|  .  .|..|.....  ...|| ..|||||.|||.||.  .        .  ... ......|..|  ||.. .|..|.
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgqlrfL

LM
|.
le
subfamily_CG42327_pd Subfamily CG42327 143-304 1e-17 58.8 In-house 29-190 (319) alignment 
Range on Protein: 143-304
Range on HMM: 29-190/319.0
SEKCRYYDILCPDATRVVLQNRPPD--NDFIHANWMTMPDK--FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNIS--H
 .| |. ...    ||||||. . |  . ...|...  .|.    ||.|| .....  ||| .|.  ..  .| ..|  | ||..|..|.|...     .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

VCGIYRITKIDqmTMVYADVALQSFEISVTDKSLecpSLVVKHYHFlKWRDHTAPMTSISVLKLLKAL
. | ...|  .    |    |. .. .   ||..   |  . || . || .   |    ... .|   
lyGdilvtlkg..revkdryaistlllkrvdkee...srelthywy.kwleaevPaeeaaliamllev
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 131-382 1.2e-16 55.2 In-house 36-284 (303) alignment 
Range on Protein: 131-382
Range on HMM: 36-284/303.0
PSTCVADTMKKHSEKCRYYDILCPDATRVVLQnrppDNDFIHANWMTMPDKFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMI-CDWEEDGIQKCSRYIP
| .   . . |  .| |. |..| | ..| |     |  .|||... .  . . | .| |. .|  ||| |.  .|   |...  | | | .   | .  
ppsvsknqfvknmdknrfvdvicldhskvkls....dssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr

SEDNISHVCGIYRITKIDQMTMVyADVALQSFEISVTDksLECpSLVVKHYHflKWRDHTAPMT-----SISVLKLLKALRDPKRPGPPVIHCSAGIGRT
 .| .       |. .. .. ..    .|.   .|  |    .  | |.||.  .|   . |          . .|   ||      |.|    .| ||.
nqdflkfeersirvgefkrvelg.dgwvlkvlsvsngd..yks.flhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgra

ATLIGVDYGNQRI-GEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIADRMVLDGV
 |.   .     .  |   ....  .  .|. | .|||   || ..   .|. .. .|.
gtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 182-368 1.8e-15 51.7 In-house 5-197 (199) alignment 
Range on Protein: 182-368
Range on HMM: 5-197/199.0
FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDqmTMVYADVALQSfeISVTDKSLECPSL-VVKHY
 |||..| |. .|. ||| ||.   .  .||. | . .     . | |. .. .   |   .|       . .| .. .  . .|...   ||   . ||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittkpdytita..liltnnttappstreishy

HFLKWRDHTAPMTSISVLKLLkALR------DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEvGEMNV---LDIVREMRQMRDKAVQSHH--QFIF
 |  |...|.|  .. |  .. | |      . ..  | ..||| | | |  .. .| | .   |     |   ... . .|| |   . | .  .||.
qftswkekttpnvalfvgfvv.asrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 182-368 1.8e-15 51.6 In-house 4-196 (198) alignment 
Range on Protein: 182-368
Range on HMM: 4-196/198.0
FRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDqmTMVYADVALQSfeISVTDKSLECPSL-VVKHY
 |||..| |. .|. ||| ||.   .  .||. | . .     . | |. .. .   |   .|       . .| .. .  . .|...   ||   . ||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittkpdytita..liltnnttappstreishy

HFLKWRDHTAPMTSISVLKLLkALR------DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEvGEMNV---LDIVREMRQMRDKAVQSHH--QFIF
 |  |...|.|  .. |  .. | |      . ..  | ..||| | | |  .. .| | .   |     |   ... . .|| |   . | .  .||.
qftswkekttpnvalfvgfvv.asrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 274-413 2.6e-13 44.1 In-house 88-224 (440) alignment 
Range on Protein: 274-413
Range on HMM: 88-224/440.0
SLVVKHYHFLKWRDHTAPMTSISVLKLLKALRDPK---RPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMl
| ..|.||.  | |.  |  .  |||... . . .     || ..||||| |||. .| ||   .      ..... ..  ||. | . ||. .|. |. 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv.

mciaDRMVLDGVPQNDNMLdLADFYTEFMKKVLMERKKKDEAE
       ||.|.   | .. | |  || .... .   . |.. 
....heavlegllcgdtli.ledditerveqiqwpnphtdksp
subfamily_eak_pd Subfamily eak 168-294 1e-12 42.1 In-house 78-198 (332) alignment 
Range on Protein: 168-294
Range on HMM: 78-198/332.0
NDFIHANWMTMPDKF-RYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDQmtMVYADVALQSFEISVT
. .| |  . ...   .|| .  . .. |  || ||. .|.||.|.. .  | ...|  .| | .       ||. ... .   .  . .  . .|.|. 
lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrniletrllelskG

DKSLEcpslvVKHYHFLKWRDHTAPMTS
... .     |.||..  | . | |.  
nethr.....vlhykvfGwtettlpkye
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 185-369 7.2e-11 35.3 In-house 118-301 (346) alignment 
Range on Protein: 185-369
Range on HMM: 118-301/346.0
ISAQGP---MDQTVEDFWHMVYTEKAPAVVMICDweEDGIQKCSRYIPSEDNishvcGIYRITKIDQMTMVYADVALQSF--EISVTDKSlECPSLVVKH
| || |    .  |||||.|.| |.   | ..    .| ... .  .  ..|     | |. |    .    |||. .     | |  .  .  |.... 
ivaqlpqmenesfvedfwymiyqeqihlvylmvp..ddklkntttslfnden.....ggyqytgkmfinnrradvsgdpkeytievlpeg.nsdsvicqv

YHFLKWRDHTAPMTSISVLKLLKALRDPKR---PGPPVIhCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFM
.|   |.    |  .. ..|... .   |.    |  |.    | ||. ..||  |  ... .  | |...|.....| |  .|.|  |.  .
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasi
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 168-229 7.8e-11 35.9 In-house 90-154 (349) alignment 
Range on Protein: 168-229
Range on HMM: 90-154/349.0
NDFIHANWMTMPD---KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIP
.|.| ||.. ..    ...||. | |.  ||.||....  .. . |. . | .| ...|| .|  
ddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_CG42327_pd Subfamily CG42327 310-370 6e-10 33.3 In-house 247-308 (319) alignment 
Range on Protein: 310-370
Range on HMM: 247-308/319.0
PGPPVIHCSAGIGRTATLIGVDYGNQRIGEV-GEMNVLDIVREMRQMRDKAVQSHHQFIFML
 || |.||| |.||| ..|  |   ... |    ... ..|  .|. | .||.. .|. |. 
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy
0038934 (Phosphotyrosine protein) phosphatases II 276-368 5.5e-09 31.4 In-house 79-168 (194) alignment 
Range on Protein: 276-368
Range on HMM: 79-168/194.0
VVKHYHFLKWRDHTAPMTSI--SVLKLLKALRDPKRPGPPVIHCSAGIGRTATLIGVDYgnqriGEVGEMNVLDIVREMRQMRDKAVQSHHQFIF
 ......    |.|.| ..|  . |.|..   . . .|  ..|| ||.|||.||..         ..  |.. . .. .|..| .|... ...  
gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYL.....iyrlgmsaeeAialfrekRpgaipnqdylea
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 124-220 8.9e-09 29.3 In-house 19-123 (347) alignment 
Range on Protein: 124-220
Range on HMM: 19-123/347.0
DFVALRAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQN-----RP--PDNDFIHANWMTMPD-KFRYISAQGPMDQTVEDFWHMVYTEKAPAVVMICD
. .|  .|| . .   .|  .| |  |    |||||||        .  . . .| |  . . . .  || .| |. .|| |||.||.  |   || | .
enlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

WEEDG
  .| 
pikde
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 306-372 3.4e-07 24.4 In-house 224-290 (297) alignment 
Range on Protein: 306-372
Range on HMM: 224-290/297.0
DPKRPGPPVIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMC
.  |. . ..|||||.||.  ..  |   ...      .|  |.. .|. | . ||. .|| ..   
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
Spore_coat_CotO Spore coat protein CotO 18-91 2.9e-06 13.2 Pfam-A 31-102 (185) alignment 
Range on Protein: 18-91
Range on HMM: 31-102/185.0
VVEKKVDKK-GKKNGSKEEKSRNPEKEEKskfKDLKEEKSKVPDDGKKQEDKKEVKKEEKKKDEKNKKSKNRKSK
.. || ..|  .|. |.|.|  ..|....   .|| .|...  .  .........|.|| ........ .... .
fiikkekekeeekeksnekkeekkeeqke...edleveseeeaeepesedeqesakqeeieqevekeeeeeeeke
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 314-373 3.8e-06 21.2 In-house 2-61 (69) alignment 
Range on Protein: 314-373
Range on HMM: 2-61/69.0
VIHCSAGIGRTATLIGVDYGNQRIGEVGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCI
|.|||.| ||| |.| .     ||     ..... |. ||. |   |    ..||.   .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_PTPDC1_pd Subfamily PTPDC1 280-366 8.6e-06 20.3 In-house 85-165 (182) alignment 
Range on Protein: 280-366
Range on HMM: 85-165/182.0
YHFLKWRDHTAPMTsISVLKLLKALRDPKRPGPPVIHCSAGIGRTATLIGVDygnqrIGEVGEMNVLDIVREMRQMRDKAVQSHHQF
.. . |.|. ..    ..| . | .    . |   .|| || |||  || .      .  . ...  . .. .|. | |..|...| 
vynfgwkDygvasl.eriLdivkvvafalqegkvavhChaGlGrtGvliacy.....lvyakrltaekaiklvrskrpksiqtreqv