Gene F36H1.3 in Caenorhabditis elegans

Synonym: CELE_F36H1.3, CELE_F36H1.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf9
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP077_AA protein Get Run
CeleP077_AA_106-378 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 95-384 4.4e-181 594.9 In-house 1-290 (290) alignment 
Range on Protein: 95-384
Range on HMM: 1-290/290.0
PDALNRHSVQTEAFETFTTTVTSMGVDGLAKEYLETLVPFLPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILKDGYPGDYVHANYVKGTKPMFILTQ
|||||||||||||||.|...|....||.|||||||.|.|.|||.|.||.||||||||||||||||.|||||||||||||.|||||||||||.|.||||||
pdalnrhsvqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltq

GPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIAL
|.||||..|||||||||.||||.|||||||.|..|||.|.|..||.|||||||||.|.|....|.....|.|.|.||.|||.|||.|.||..|||||.||
GalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksval

SNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAFKYIE
|.||.|||||.|||..||.||||||||||||||.|||||.|.||.||.....|||||.|..||||||.|.|||.|||..||||..|||||
stlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyie
0050432 (Phosphotyrosine protein) phosphatases II 104-379 1.1e-77 256.7 In-house 25-301 (308) alignment 
Range on Protein: 104-379
Range on HMM: 25-301/308.0
QTEAFETFTTTVTSMGVDGLAKEYLETlVPFLPvgYFERSIFDKNTEFKKNRYKDVPCNDKTRVILkdGYPGDYVHANYVKGT----KPMFILTQGPLKD
..   .        ..  .| .|. |    . |  ..|.|.. .   ..||||||....|..||.|  . . ||..|.||.|     .  ||.|||||..
klsvldllkllekaldlglleeefeel.lsvkp..lleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpn

TAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEG-QVLTFGEITVTCTESTTpDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLA
|  | |||| ...|  | ||..|.||||.||..|.|...| ..|..| .|||... .. ...  .  |.......|.|....|.  ..||| ..  |  .
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspei

ILRTLRSLRKM--PGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVA
.|. |. .||.  .||||||||||.||||||.|...  ..|  .. . . ..|. .|..| ..||   ||| | .|.|..   
lldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0040438 (Phosphotyrosine protein) phosphatases II 108-379 1.7e-76 252.9 In-house 5-278 (317) alignment 
Range on Protein: 108-379
Range on HMM: 5-278/317.0
FETFTTTVTSMGVDGLAKEYLETLVPFLPvgyfERSIFDKNTEFKKNRYKDVPCNDKTRVILKDGYP---GDYVHANYVKGT--KPMFILTQGPLKDTAM
.. .  ..  ... .| .|. . |  .|.    ..|.. .    .||||.|....| .||.|..  .    ||..|.||.|   |. ||.|||||..|  
lllalldllksdftalleefedllslkld....tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntve

DIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDteGQVLTFGEITVTCTESTTpDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRT
| |||| ..||  | ||.|| |.||.||..|.|.  |..||.|..|||... .. ... .|  |.| |.....|....|.  ..||| ..  |   .|. 
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldf

LRSLRKM----PGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVA
|. .|.     .||..||||||.||||||.|...  ..|  .. . . . |. .|..| ..||.  ||  | .|.|..   
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0036941 (Phosphotyrosine protein) phosphatases II 125-384 6.7e-76 250.7 In-house 16-284 (297) alignment 
Range on Protein: 125-384
Range on HMM: 16-284/297.0
KEYLETLVPFLPVGYFERSIFDKNTefKKNRYKDVPCNDKTRVILkDGYPGDYVHANYVKGTK--PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCEL
... |.|.|.|. | .. ... .|   .||||||....|.|||.| |. . ||..|.||.| .    ||.|||||..|  | ||||....|  | ||.||
lkefeellpllllgslsvallpenl..eknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltel

IENGRPKCEPYFPDTEGQVLTFGEITVTCTESTT-PDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK------MPGPIVV
.|.||.||..|.|..||..||.|..|||... .. ....  |  |.| |...|.|....|. ...||| ..  |   .|. .. .||       .||..|
velgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlV

HCSAGIGRTGTFAAIEVGAQCLL---NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAFKYIE
|||||.||.|||.|...  |.|      . . . ..|. .|..| ..||.  ||. | ||.|.|   ....|
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0046845 (Phosphotyrosine protein) phosphatases II 124-378 3.4e-74 245.1 In-house 3-275 (284) alignment 
Range on Protein: 124-378
Range on HMM: 3-275/284.0
AKEYlETLVPFLPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILKDGYP----GDYVHANYVKGT-------KPMFILTQGPLKDTAMDIWRMVLQEG
 .|. |.|. . .  ....|.. .   ..||||||....|..||.||   .    .||..|.||.|        |. ||.|||||..|  | ||||....
eeef.eellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VAAICMLCELIENGRPKCEPYFPDTeGQVLTFGEITVTCTESTTpDNHTQLKMLTVMDKK-SGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM--
|  | ||.||.|||| ||..|.|.. |.|||.|..|||... .. ...  . .|.. ... .|.|....|. ...||| ..  |   .|. || .|..  
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

----PGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGK---AFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGV
    .||||||||||.||||||.|...  ..| ...    . . ..|. .| .| ..||.  ||... ||.|..  
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0051299 (Phosphotyrosine protein) phosphatases II 102-375 1.8e-73 242.8 In-house 4-284 (288) alignment 
Range on Protein: 102-375
Range on HMM: 4-284/288.0
SVQTEAFETFTTTVTSMGVDGLAKEYLETLVPFLPvgyFERSIFDKNTEFKKNRYKDVPCNDKTRVILKDGYP---GDYVHANYVKG--TKPMFILTQGP
....| .. .  ...  |. ||..|. | |  . .   ...|.. .   ..||||.|....|..||.|..  .   .||..|.|..|  .|  ||.||||
eisveellklvlkllangltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

LKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDteGQVLTFGEITVTCTESTTpDNHTQLKMLTVMDK----KSGKSHKLYHYKIITWPDKSI
|..|  | |||| ...|  | ||..|.|.|| ||..|.|.  |..||.|.||||... .. ...  .  |.| ..    ..|.|.. .|.  ..||| ..
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

ALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
  |  ..|. || .||.    .||.|||||||.||||||.|...  ..|.... . . ..|. .|..| ..||.  ||... ||.|.
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
DSPc_SM00195 140-376 8.7e-73 240.2 In-house 18-261 (263) alignment 
Range on Protein: 140-376
Range on HMM: 18-261/263.0
FERSIFDKNTefKKNRYKDVPCNDKTRVILKDG---YPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYF
.. ....||.  .|||||.....|.|||.||.     . ||..|||.||.  |  .|.|||||..|  | ||||..|.|  |.||.|  |||. ||. |.
tteaekkknk..sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PDTEGQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAI
|...|.  |||.|.|...| .. .....|. |..  ..  ...|...|.. .|||...  |.  .|. ||...|      ||||||||||.||||||..|
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

EVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
..  . | ..| .   ..|...|. | ..||...|||...||||..
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 140-376 8.7e-73 240.2 In-house 18-261 (263) alignment 
Range on Protein: 140-376
Range on HMM: 18-261/263.0
FERSIFDKNTefKKNRYKDVPCNDKTRVILKDG---YPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYF
.. ....||.  .|||||.....|.|||.||.     . ||..|||.||.  |  .|.|||||..|  | ||||..|.|  |.||.|  |||. ||. |.
tteaekkknk..sknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PDTEGQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAI
|...|.  |||.|.|...| .. .....|. |..  ..  ...|...|.. .|||...  |.  .|. ||...|      ||||||||||.||||||..|
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvti

EVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
..  . | ..| .   ..|...|. | ..||...|||...||||..
diilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0047943 (Phosphotyrosine protein) phosphatases II 119-375 4.1e-72 238.2 In-house 10-270 (273) alignment 
Range on Protein: 119-375
Range on HMM: 10-270/273.0
GVDGLAKEYLETlVPFLPvgYFERSIFDKNTEFKKNRYKDVPCNDKTRVILkDGYPGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAI
|...|..|. .  ... |  ....|.. .   ..||||||....|..||.| .. . ||..|.||.|  .|. ||.|||||..|  | |||| ...|  |
gltllleefell.lslkp..lltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

CMLCELIENGRPKCEPYFPDTEGQ-VLTFGEITVTCTESTTpDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK------M
 ||.||.|.||.||..|.|...|. .||.|..|||... .| ...  .  |.. ....|.|.. .|.   .||| ..  |   .|. .. .||       
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

PGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
.||.|||||||.||||||.|...  ..|  .. . . ..|. .| .| ..||   ||..| ||.|.
ngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
Y_phosphatase Protein-tyrosine phosphatase 151-374 6.3e-71 233.9 Pfam-A 2-234 (235) alignment 
Range on Protein: 151-374
Range on HMM: 2-234/235.0
FKKNRYKDVPCNDKTRVIL-KDGYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEI
.|||||||... ||||| | ... | ||..||||||.  | .||.||||||.|  | ||||.|| | .| ||..| |.|| ||..|.|..|.. ||.|.|
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTCT-ESTTPDNHTQLKMLTVMDKKSGK-SHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMP----GPIVVHCSAGIGRTGTFAAIEVGAQCLLNGK
.|... .... .....|. |.. .||. . ....... . .|||...  |. ..|...|...|      ||.|||||||.||||||.|...  ..| ...
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

AFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
 .   ..|. .|..| ..||  .|| .|..|||
evdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 151-374 6.3e-71 233.9 In-house 2-234 (235) alignment 
Range on Protein: 151-374
Range on HMM: 2-234/235.0
FKKNRYKDVPCNDKTRVIL-KDGYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEI
.|||||||... ||||| | ... | ||..||||||.  | .||.||||||.|  | ||||.|| | .| ||..| |.|| ||..|.|..|.. ||.|.|
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

TVTCT-ESTTPDNHTQLKMLTVMDKKSGK-SHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMP----GPIVVHCSAGIGRTGTFAAIEVGAQCLLNGK
.|... .... .....|. |.. .||. . ....... . .|||...  |. ..|...|...|      ||.|||||||.||||||.|...  ..| ...
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaee

AFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
 .   ..|. .|..| ..||  .|| .|..|||
evdvlqivkelRkqRpgmvqsleqYiflykail
0045450 (Phosphotyrosine protein) phosphatases II 119-376 8.2e-71 234.6 In-house 25-303 (307) alignment 
Range on Protein: 119-376
Range on HMM: 25-303/307.0
GVDGLAKEYLeTLVPFLPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILKDGYP----GDYVHANYVKG----------TKPMFILTQGPLKDTAMDI
.. ||.||.  .|... .  ..|.||. .    .||||||....| |||.|..  .    .||..|.||.            |  ||.|||||..|  | 
fltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedF

WRMVLQEGVAAICMLCELIENGRPKCEPYFPDTeGQVLTFGEITVTCTESTTpDNHTQLKMLTVMDK-KSGKSHKLYHYKIITWPDKSIALSNLAILRTL
|||. ..|| .|.||.||.|.||.|| .|.||. |..||.|..|||... .. ... ..  |.| |. ..|.|....|.  ..||| ..  |   .|. .
wrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi

RSLRK------MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKA---FRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
. .||       .||..||||||.||||||.|. .  ..| ...    . . . |. .| .| ..||   ||  | ||.|.|
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 122-375 1.8e-67 223.0 In-house 21-275 (278) alignment 
Range on Protein: 122-375
Range on HMM: 21-275/278.0
GLAKEYLeTLVPFLPvgyFERSIFDKNTEFKKNRYKDVPCNDKTRVILKD---GYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAI
.| .|.  .|  | .   ...||. .   ..||||||....| .||.|..    .. ||..|.||.|   .. ||.|||||..|  | |||| ..||  |
llllefe.ellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

CMLCELIENGRPKCEPYFPdteGQVLTFGEITVTCTESTTpDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK----MPGP
 ||.|| |.||.|| .|.|   |..||.|..|||... .. ...  .  |.| ....|.|.. .||  . ||| ..  |   .|. |. .|.     .||
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

IVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
..||||||.||||||.|...  ..| ... . . . |. .|..| ..||.. || .| ||.|.
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 95-376 2e-67 223.1 In-house 6-288 (297) alignment 
Range on Protein: 95-376
Range on HMM: 6-288/297.0
PDALNRHSVQTEAFETFTTTVTSMGVDGLAKEYLETLVPFLPvgyfeRSIFDKNTEFKKNRYKDVPCNDKTRVILKDG----YPGDYVHANYVKGTKP--
. .|.  ........ .    . ..  .| .|. | |  . .     .||. .    .||||||....| .||.||.      . ||..|.||.| .   
dallesipiplsvldlllllekansktllllefeellslkpd.....ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydllt

-MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRpKCEPYFPDTEGqvlTFGEITVTCTESTTpDNHTQLKMLTVMDkkSGKSHKLYHYKIITW
  ||.|||||..|  | |||| ..|| .| ||..|.|.|| ||..|.|...|   |.|..|||... .. ...  .  |.| .  .|.|....|.  . |
rkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgw

PDKSIALSNLAILRTLRSLRK------MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
|| ..  |   .|. |. .|.       .||..||||||.||||||.|.    ..|  .. . . . |. .| .| ..||.. ||  | .|.|.|
pdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0045098 (Phosphotyrosine protein) phosphatases II 135-377 8.5e-67 220.8 In-house 20-272 (278) alignment 
Range on Protein: 135-377
Range on HMM: 20-272/278.0
LPVGYFERSIFDKNteFKKNRYKDVPCNDKTRVIlkdgypgDYVHANYVKGTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYF
 ... .. ... .|  ..||||||....| .||.       ||..|.|..| .. ||.|||||..|. | |||. ..|. .|.||.||.|.|| ||..|.
gipseitpalylgn..ldknRykdilpydhsrVk.......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqyw

PDteGQVLTFGEITVTCTESTTPdNHTQLKMLTVMDK----KSGKSHKLYHYKIITWPDKSIALSN-----LAILRTLRSLRK--------------MPG
|.  |..||.|..|||... ..  ..  | .|.| .     ....|....|.....||| ..  ..     | .|. .|. .|               .|
pe..ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGIGRTGTFAAIEVGAQCLlnGKAFRPADLVRAVRHCRLN-SVQMDTQYLMLVEAILDLG
|..||||||.|||||..|.    ..|  .. . . . |. .| .| . .||.  ||  | |..|.| 
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0040439 (Phosphotyrosine protein) phosphatases II 143-376 5.6e-66 218.0 In-house 4-245 (249) alignment 
Range on Protein: 143-376
Range on HMM: 4-245/249.0
SIFDKNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDt
|.. .    .||||.|....| .||.|   ......||..|.|..|.  |. ||.|||||..|  | |||. ..|. .|.||..| |.|| ||..|.|. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

eGQVLTFGEITVTCTESTTpDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK------MPGPIVVHCSAGIGRTGTFAAIE
 |..|..|..|||... ..  ..  . .|.. ... |.|.. .|. .. ||| ..  |   .|. .. .||       .||..||||||.||||||.|. 
.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaay

VGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
   ..|   . . . . |. .|..| ..||.. ||  | ||.|.|
lmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 149-375 2.6e-62 205.7 In-house 8-241 (245) alignment 
Range on Protein: 149-375
Range on HMM: 8-241/245.0
TEFKKNRYKDVPCNDKTRVILKDGYP---GDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDteGQVLT
   .||||.|....| |||.|..  .    ||..|.||.|   .| ||.|||||..|  | |||. ..|. .|.||.|. |.||.||..|.|.  |..||
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslt

FGEITVTCTESTTpDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK-----MPGPIVVHCSAGIGRTGTFAAIEVGAQCLL
.|..|||... .. ...  .  |.| ......|.. .||  . ||| ... .   .|. |. .||      .||..||||||.||||||.|.   ...| 
ygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
  . . . . |. .| .| ..||.. ||  | ||.|.
kelgvsleeavkelrsqRpgavqtpsqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 148-375 4.7e-61 201.7 In-house 8-240 (243) alignment 
Range on Protein: 148-375
Range on HMM: 8-240/243.0
NTEFKKNRYKDVPCNDKTRVILKDgypGDYVHANYVKGTkPMFILTQGPLKDTAMD----IWRMVLQEGVAAICMLCELIENGRPKCEPYFPdteGQVlT
    .||||.|....| .||.|..   .||..||....| | .|.|||||..|  |     |||. ..|. .|.||.||.|.|| ||..|.|   |.| |
penlsknrysdilpydhsrvkleg...sdyinanliyvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.t

FGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM------------PGPIVVHCSAGIGRTGTFAAIE
.|..|||...... |. |. ..| .. . .. ..  .||  . ||| ..  |   .|. |. .|.              ||..||||||.|||||..|. 
ygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaay

VGAQCLlngKaFRPADLVRAVRHCRLN-SVQMDTQYLMLVEAILD
.  ..|   . . . . |. .| .| . .||   ||  | ||.| 
lmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN9_pd Subfamily PTPN9 109-376 8.5e-57 187.4 In-house 4-289 (297) alignment 
Range on Protein: 109-376
Range on HMM: 4-289/297.0
ETFTTTVTSMGVDGLAKEYLEtLVPFLPVGYFERSIFDKNteFKKNRYKDVPCNDKTRVILK---DGYPGDYVHANYVKGTK--PMFILTQGPLKDTAMD
| . . | ..|  || |||.| .    ..| |..|    |   .||||.|| | |.||| |.   .    ||..||.| | |    || |||||| |  |
eelvayvkekgkrGlskeyae.irnepveGtflasklran..leknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

IWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTESTTPDNHtQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTL
 |||| .. |  | |   ..|.|| ||  |.|..|...  ||...|.  |  . ... . ..|.. . | ..| |. |.....|||  .  |  ..|  |
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedy.kvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

RSLRKMP-----------------GPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
.  |..                   ||||||||||||||||.....  . | .       . |. .|  |  |.|.. || .   |.|. 
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 144-377 1.6e-56 186.3 In-house 42-287 (305) alignment 
Range on Protein: 144-377
Range on HMM: 42-287/305.0
IFDKNTEFKKNRYKDVPCNDKTRVILKDGYPGDYVHANYVKG-TK-PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQV
 | .  | .||||||| | |. || |.  .| .|.|||||   |.   || || ||..|  |.| | ||. | || |||.|.| |  ||  ||.  ...|
afkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

LTFGE----ITVTCTESTTPD----NHTQLK-MLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEV
|.| |    |.| .  |.| .     .....    |..   .|..|  ||. | |||. .  ..||||  |   |   |||||||||||||||.   .| 
lefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmley

GAQCLLNGKAFRPAD-LVRAVRHCRLNSVQMDTQYLMLVEAILDLG
  . ||.|.    .| ... .|  | ||.| |.|||.. . ||.  
ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_PTPN3_pd Subfamily PTPN3 147-375 4.6e-55 181.5 In-house 38-273 (280) alignment 
Range on Protein: 147-375
Range on HMM: 38-273/280.0
KNTEFKKNRYKDVPCNDKTRVILKDGYPgDYVHANYVKGTKPM------FILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDtEGQ
|  . .||||.|.   |.|||.||..   ||. ||||.   |       .| |||||..|| | |.|| .. .  |.|| .|.|.|| ||  |.|. ...
kpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.ted

VLTFGEITVTCTEStTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRT---LRSLR-KMPGPIVVHCSAGIGRTGTFAAIEVGAQC
 |..||..|.|...   ..   |. |...||.. ...|. . . . |||...  ..  .|.    .|.||  .  |.|||||||||||| . ..|.  . 
eleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal

LLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
. . ... | |.|| .|  | . ||  .|| .. |||| 
ieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 116-389 5.5e-55 181.5 In-house 11-288 (307) alignment 
Range on Protein: 116-389
Range on HMM: 11-288/307.0
TSMGVDGLAKEYlETLVPFLPVGYfERSIFDKNTEfkKNRYKDVPCNDKTRVILK-DGYPGDYVHANYVK-GTKP-MFILTQGPLKDTAMDIWRMVLQEG
  .||. |  |. . |    | |      |. ||.  ||||.||.| ||.|...| ||   ||.||||.   .||  || .||||..|  ..| |..|| 
ldkgvqalvdef.rvlakktpegv.tveafsantd..knryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqek

VAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCT------ESTTPDNHTqLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL
| .. |||..|| .. ||| |.|  ||| |.||| . | .      .  .||..  ... |.  . ..||  . |..   |||. .   ||. .  | . 
vesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedl.invttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav

RKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRP-ADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAfKYIEDPKSL
|    |.|||||||.||.||  || .  . ...|.  .   .||. .|  |  ..| . ||| |   .|.  .  .| |  . |
rydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle.lyketyeel
subfamily_PTPN12_pd Subfamily PTPN12 144-376 3.3e-53 175.4 In-house 34-276 (290) alignment 
Range on Protein: 144-376
Range on HMM: 34-276/290.0
IFDKNTEFKKNRYKDVPCNDKTRVILKDGYP---GDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTE
  .|... |||||||.   ||.|| |.        ||. ||..||.  | ..| .|||| .|  | |||. .  |  . |.|...|.|. ||| |.|.. 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

GQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKksGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAIEVGA
.. |.|||..||..|  . |.   ...|.|  .  ..|.|.| ..   |||. .  |   .|. ....|..      |.|||||||.|||||  ||.   
eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvr

QCLLNGKA---FRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
. | ..|    .   |||. .|. |   ||   || .. .|...|
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_PTPRB_pd Subfamily PTPRB 146-376 1.5e-52 173.5 In-house 47-284 (293) alignment 
Range on Protein: 146-376
Range on HMM: 47-284/293.0
DKNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKGTKP--MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQ
..... .||||...   |..|| |   ||    ||. |||..| .    || ||||| .|  |.||||... . .| || .|.|.|. ||| |.|..| .
elavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeep

VlTFGEITVTCTESTTPDNHTQlKMLTVMDkkSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMP------GPIVVHCSAGIGRTGTFAAIEVGA
| ..|.|.|| ..... ....  . |..    . ...|. .|. ..|||  .  .  ..|. .| .|..       .|||||||||.|||||| |..   
v.lyGdikvtlvaeeeledwvi.relkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll

QCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
| . .      . .| ..|. | . ||  .||... ...|||
qaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_PTPRD_pd Subfamily PTPRD 146-375 2.4e-52 173.4 In-house 44-279 (564) alignment 
Range on Protein: 146-375
Range on HMM: 44-279/564.0
DKNTEFKKNRYKDVPCNDKTRVILKD--GY-PGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTeGq
.|..  .||||...   |..||.|.   |    ||. |....|  ..  .| |||||..| .| |||| .. .. | || .| |.|. ||. |.|.. | 
nkpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.

VLTFGEITVTCTESTTPDNhTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAIEVGAQC
  |.||.||| .|...  .  ... ... .||| .|..  ... . |||. .  |  ..|. .|  |..     ||||||||||.|||||| .|..  . 
tetygeltVtleeeeelad.yeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamler

LLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
. . |       |.|.|. |   ||  .||  . ||||.
ikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile
subfamily_PTPN6_pd Subfamily PTPN6 114-374 2e-50 166.5 In-house 19-294 (306) alignment 
Range on Protein: 114-374
Range on HMM: 19-294/306.0
TVTSMGVDGLAKEYlETLVPFLPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVIL-KDGYPG-DYVHANYVK----GTKPMFILTQGPLKDTAMDIWRM
. .|..  |. .|. |.|       ...|.  .|..  .||||| .   |.||||| ... || ||. |||.|    |..  .| ||| |..|  | |||
eeeslekagfeeef.eelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLtFGEITVTCTESTTPDNHtQLKMLTVM-DKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL
|.||    | |. . .| |. || .|.||.| .   .|.|.||...... ..  .|. |.|   ||.........|.  .|||...  .  |.|  |. .
vwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladY.ilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledv

RK--------MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADL---VRAVRHCRLNSVQMDTQYLMLVEAIL
..         .|||||||||||||||||  |..  . . . .   . |.   |. ||. |   ||...|| .. .|| 
nrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_PTPN13_pd Subfamily PTPN13 147-375 2.3e-49 163.1 In-house 34-267 (273) alignment 
Range on Protein: 147-375
Range on HMM: 34-267/273.0
KNTEFKKNRYKDVPCNDKTRVILKDGYPgdYVHANYVKG----TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVL
|. . .||||..|   |.|||.|.|  .  |. |...|      .  .|..|||| .|. |.|.|| .  .  | |.    |.|. ||. |.|..... |
kkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkkl

TFGE-ITVTCTESTTPDNHTQlKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM---PGPIVVHCSAGIGRTGTFAAIEVGAQCLL
.  . ..|.  . .  |. .. . |.| |..||.|... | . ..||| ..  | . .|. .. .|..    |||||||||||||.||. .|.|  . . 
kvsnrlevellkvqkldgfvv.ralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglie

NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
. | |   ..|| .|. |   || . ||..  .|||.
rdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 147-376 3.2e-49 162.2 In-house 52-288 (305) alignment 
Range on Protein: 147-376
Range on HMM: 52-288/305.0
KNTEFKKNRYKDVPCNDKTRVILKDGYPGDYVHANYVKGT---KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLT
 . .  ||||.||||.|.. | |..  | ||.|||||      .  || .|||| .|  ..| ||.|. |  | |||  .| |. ||  |.| . |. |.
adiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

FG-EITVTCTESTTP---DNHTQLKMLTVMdKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLN
.   | |     . |   |.  |. .| .     ...  . | .   |||. .   .|. |  | ..|    |||||||||||||||  |||   . . .
lksgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiae

GKAFRP-ADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
 |   |  .||.|.|  |  |.| | |||..   .|. 
nkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 143-384 4.7e-49 161.5 In-house 30-276 (281) alignment 
Range on Protein: 143-384
Range on HMM: 30-276/281.0
SIFDKNTEFKKNRYKDVPCNDKTRVILKDGYP----GDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPD
..|..  . ||||| ..|| | .|| ||   |     ||.||||..    |  .|||||| |.|  |.|||. ||  .|| |||...|  | ||  ||| 
tvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

TEGQVLTFGEITVTCTESTTPDNHTQLKmltVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQC
    .| | ...|.  .||        .   .     |... . |.    |||  .  |   .|. || .|    | |.|||||.||.||. |.|.  | 
nahcclqfdklsvsyedstvnkslvttr...lnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqs

LLNgkAFRPADLVRAVRHCRL----NSVQMDTQYLMLVEAILDLGVAFKYIE
. .   |   |. . | | |.     |||   ||... . .||.|||.| | 
ihs..hftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykqit
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 144-376 1.1e-47 157.7 In-house 40-282 (305) alignment 
Range on Protein: 144-376
Range on HMM: 40-282/305.0
IFDKNTEFKKNRYKDVPCNDKTRVILKD--GYP-GDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTE
.  |... .|||.|..   |. |.||.     .  ||. |.||.|   |  .|..|||||.|  | ||....| |  | ||..|.|.|. ||. |.|...
vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesk

GQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK--MPG---PIVVHCSAGIGRTGTFAAIEVG
...  |||..|. ....|  .... |.   ..... .|. . .|.. .|||. .  .  ..|. .. ..|  . .   |..||||||.||||.| |... 
tekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdia

AQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
 . | . .    .......|. |.. ||   ||  | .|. .|
lerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 111-377 1.8e-47 157.0 In-house 17-290 (298) alignment 
Range on Protein: 111-377
Range on HMM: 17-290/298.0
FTTTVTSMGVDGLAKEYLETLVPFLPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILKD---GYPGDYVHANYVKGTK--PMFILTQGPLKDTAMDIW
...   .... |.|.|. .       .  .| ..  |..  ||||| |.   |..||.|..      .||. | .... |  . ||.||.||. |  | |
laavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFW

RMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQvlTFGEITVTCTESTTPDNHTQLKmLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRS
||| .| ...| || .| | .. |.. |.||.. .  |.|||||.  .. .  . .. | |.| .||. |.... . . ..||||...  . ..|  || 
rmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrk.lkvskkkeekerevrqlhftsWpdkgvpenatsvldllrk

LRK---MPG--PIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLG
 |.     |  |..|.||||.||.||| ||.   . . . .     . |...|. | ..||  .||  . ||.|.  
vrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 116-376 3.1e-47 156.0 In-house 16-278 (288) alignment 
Range on Protein: 116-376
Range on HMM: 16-278/288.0
TSMGVDGLAKEYlETLVPFLPVGYFErsIFDKNTEFKKNRYKDVPCNDKTRVILKD---GYPGDYVHANYVKGTK--PMFILTQGPLKDTAMDIWRMVLQ
  .. .|. .|| ..| ..      .  .  .    |||||...   | .|| ||.   .   ||. |.|..|.|    .| ||||| ||  | |..| .
sarnrtgfseey.nsLaalektksvt..agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvye

EGVAAICMLCELIENGRPKCEPYFPDTEGQVlTFGEITVTCTESTTPDNHTQLKMLTVmdkKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLR---
. .  | || ||.|.|. ||| |.||.. ..  .|..||| .|| . ..... |.| .   |...  .. .|.  .|||...  |.  .|  || .    
nktstivmltelveggktkCeeYWPdadkpk.nyGsvtvtlveskeledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvan

KMP-GPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
.   |||.||||||.|||||| |..   . . . .    |. |  .|. | . ||  .||  . |..|.|
qadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 144-374 1.8e-46 153.3 In-house 14-261 (270) alignment 
Range on Protein: 144-374
Range on HMM: 14-261/270.0
IFDKNTEFKKNRYKDVPCNDKTRVILKDG---YPGDYVHANYVK---GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDT
. .  .. | |||.|.  . .|||.|..        |. ||||.   | |  .| ..|||. |  . |||...| | || |. .| |.|| ||| |.|  
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

EGQ--VLTFGEITVtCTESTTPDNHTQLKMLTVMdkKSGKSHKLYHYKIITWPDKSIALSNL---------AILRTLRSLRKMP---GPIVVHCSAGIGR
 ..   |..|.|.| ...|.. ..   |. |..   ..|....| |.   ||||...  ..          ..||..|  .|     .|..||||||.||
pkekvkledgkikv.lalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
|||. |.. . ..| . |   .. .....|. | . ||   || .| .|..
tGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 149-382 7.9e-46 151.6 In-house 45-285 (318) alignment 
Range on Protein: 149-382
Range on HMM: 45-285/318.0
TEFKKNRYKDVPCNDKTRVILKD---GYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTegQVLT
.  .|||| ..   |.||| |..       ||. |||. |   |  .| .|.|| .|  | |||| . . | | || .. |.|. |.. |.|.   .  .
vnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrs

FGEITVTCTESTTPDNHTqLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMP-----GPIVVHCSAGIGRTGTFAAIEVGAQCLL
.|...|. .|... .... |. ..|  ... .| .   |.. .|||...  |   .|  .|. .|.      ||||||||||.||||.| |...  . . 
ygklvvelkeevelsdyv.lrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerik

NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAFKY
. .     . |. .|. |   || . || .. ...|.   ... 
aealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 148-373 1.2e-45 150.7 In-house 26-264 (274) alignment 
Range on Protein: 148-373
Range on HMM: 26-264/274.0
NTEFKKNRYKDVPCNDKTRVILKDGY----PGDYVHANYVKGTK---PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQ
  . .|||||..  |...||.|.         .|. |||.|| .    ... |||||  | .| |||. || |  | || .| |. . ||. ||||.|. 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--VLTFGEITVTCTESTTpDNHTQLKMLTVMDKKSgkSHKLYHYKIITWPDKSIALSNLAILRTLRS------LRKMP-GPIVVHCSAGIGRTGTFAAIE
    ..|.. .. .. ..  |. ... |..   ..  .....||    |||.    .  ..|....        .... .|.|||||||||||| | ||.
eiserygdveikvekive.rndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

VGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAI
.. . | . .      .|  .|  |   || . || .. .|.
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 148-375 2.9e-45 149.5 In-house 39-274 (281) alignment 
Range on Protein: 148-375
Range on HMM: 39-274/281.0
NTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEgQVL
.   .||||...   |.||| .   ..    ||. ||.|.|   .  .| ||||. .. .. |.||... | || |. . ||.|. ||  |.|| . . |
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.sel

TFGEITVTCTESTTPDNHTQlKMLTVmDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL---RK--MPGPIVVHCSAGIGRTGTFAAIEVGAQCL
..|..||. |....  .. . . ... ...||.. .. . . ..|||. .  .  ..|   . .   ..     |.|.|||||.|||||. |..  .. .
kygdvtvkstaeeekatyie.rkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkav

LN-GKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
 .  .   . ..|. .|. |   ||  .||  .  |.||
eaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 112-381 1e-44 147.9 In-house 14-287 (319) alignment 
Range on Protein: 112-381
Range on HMM: 14-287/319.0
TTTVTSMGVDGLAKEYLETLVPFLPvgYFERSIFDKNTefKKNRYKDVPCNDKTRVILK---DGYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWR
.... | |  .|.||. .   .      |. .  ..|   |||||...   |.|||.|.   .    ||. |... |   .  || ||.||..|  | ||
lkalastgetllekefkllkeavnd..tfdsaskeenk..kknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MVLQEGVAAICMLCELIENGRPKCEPYFPDTegQVLTFGEITVTCTESTTpDNHTQLKMLTVmDKKSGK--SHKLYHYKIITWPDKSIALSNLAILRTLR
|| .|..  . ||..| |... |.. |.|..  .. ..|...||  |     ..   . |.. .|||..  . .. |..   |||. .  . ...|  |.
mvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeee.ledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllk

SLRK-----MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAFK
 .||       ||||||||||.|||||| ....  . . .  .      |. .|  |   ||   || .. ||.|.   |..
rirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_PTPRK_pd Subfamily PTPRK 146-375 9.8e-44 144.4 In-house 39-275 (314) alignment 
Range on Protein: 146-375
Range on HMM: 39-275/314.0
DKNTEFKKNRYKDVPCNDKTRVILK--DGY-PGDYVHANYVKGTK--PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTeGQ
 |. . .|||..|.   |..||.|.  ||    ||. |... . |    || |||||..|  | ||.|..|. |.| || ||.|.|| ||  |.|.  ..
kkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed.te

VltFGEITVTCTEStTPDNHTQLKMLTVMD--KKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAIEVGA
|  .|.| |.. |. ....    ....|    ..  . ... ... ..|||  .  |. ..|. .| . |.     |.|||||||| |||||| ||..  
v..ygdikvelvet.ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

QCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
. . . .       |...|  . | |.   || .. ..||.
dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN23_pd Subfamily PTPN23 148-375 9.9e-44 144.3 In-house 41-278 (288) alignment 
Range on Protein: 148-375
Range on HMM: 41-278/288.0
NTEFKKNRYKDVPCNDKTRVILKdGYPGDYVHANYVKG---TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTF
..  .|||..|.   |..|| |. |   ||. | .||.   . | || ||.||. |. | |.|| .. .  | || .  | |.||.. |.|  .|.  .|
klyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GEITVTCTESTTPDNHTQLKmLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTL---RS-----LRKMPGPIVVHCSAGIGRTGTFAAIEVGAQC
|...||. . .. ..| . . |..  ... . ... | .. .||.  .  |   .|. |   .|      ||.  |.|||||||.||||.|| .   .. 
gdlsvtlksvretethverv.lkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

LLNGKAFR-PADLVRAVRHCRLNSVQMDTQYLMLVEAILD
| .|.      ..|. .|. | ..||  .|. .. ||.| 
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 146-380 1.5e-43 143.8 In-house 5-245 (250) alignment 
Range on Protein: 146-380
Range on HMM: 5-245/250.0
DKNTEFKKNRYKDVPCNDKTRVILKDGY---PGDYVHANYVKGTK--PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPkCEPYFPDTegQ
 |  . .|||| |.   |..||.|.        ||. | ...| .   .|| |||||..|  | |||||.| ...| || .| |...  .. |.|    .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..k

VLTFGEITVTCTESTTPDNHTQlKMLTVMDKKSGKSHKLYHYKIITWPDKSIA---LSNLAILRTLRSLRKM--PGPIVVHCSAGIGRTGTFAAIEVGAQ
  ..|..||.  .. .  . |. . | .  .|  ..  . ... ..||||..     . |..|. ... ..    .|..|.||||.||.|.| ||.   .
aekyGdvtvsllskeefadytk.rklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

CLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVAF
 | . |     ......|. | ..|.  .|| .. |.||   ...
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_PTPRG_pd Subfamily PTPRG 107-376 2.8e-43 143.0 In-house 5-286 (563) alignment 
Range on Protein: 107-376
Range on HMM: 5-286/563.0
AFETFTTTVTSMGVDGLAKEYLETLVPfLPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILKD--GYPG--DYVHANYVKGTK--PMFILTQGPLKDT
 |.   . . . |  |...|. .         ... .  .|. . .|||| ..   |..|| |..  |  .  ||. |||..| .    || ||||||||
efakhvaslhadgdigfseefealqse.tiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdt

AMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDteGQVLTFGEITVTCTESTTPDNHT----QLKMLTVMDKKS-GKSHKLYHYKIITWPDKSIALS
. | |||. .. || | |. .| |.|| ||. |.|    ...|.|...|| .|. .    |    ..| | . .||.  . .. ..|.  .|||..   .
fddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

NLAILRTLR----SLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
.|  |   .    . ..  ||||||||||.|||||. ...   . . . .|    .... .|  | . ||   ||. | .|.|..
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 105-379 3.5e-43 142.7 In-house 3-273 (288) alignment 
Range on Protein: 105-379
Range on HMM: 3-273/288.0
TEAFETFTTTVTSMGVDGLAKEYLETlvpflPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILKDGyPGDYVHANYVKGTKP--MFILTQGPLKDTAM
.|   ..   | ...|.|| ||| ..     | .  ...|    ..  ..||...|. | ||| |.|  |  |..|| |  .|    .| .| ||. |  
kevinawirlvlqiaveglkkeyrds.....pneasidiidsfianptrdryenlprcditrvklsdd.pdfyiaanvvssakykrrlicaqaPlngtie

DIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEItVTCTESTTPDNHTQLKMLTVMDKKSGKSHK-LYHYKIITWPDKSIALSNLAILR
 .|.|.|...|  | |||||.| |..| . |||   |.   .| .  | .     | .  .|. ..  .| |. .. . .  .  |.|...  . |. ||
elWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr

TLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGVA
 |  |...  |||||.|||.|||||.. | . .. |          |.   |  | ...|   ||| .   .|.  . 
llevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 151-375 3e-42 139.5 In-house 47-281 (290) alignment 
Range on Protein: 151-375
Range on HMM: 47-281/290.0
FKKNRYKDVPCNDKTRVILK--DGY---PGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVlt
 ..||....  .|  |..|.   |    . .|..| |.||   |  .|.||||...|..| |... || |..| ||.. ||.|. ||  |.||.. .   
kllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..

FGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKS----IALSNLAILRTLRSLR-KMPGPIVVHCSAGIGRTGTFAAIEVGAQCLL
.||.... .. .| .. .. |.    ....|..... .|.| .|...      . . |.| .  .  | .  ..||||||...||...| |.... .   
ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkck

NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
        ....  | .. .|||   || .... .| 
tegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 147-375 3.8e-42 139.2 In-house 41-275 (315) alignment 
Range on Protein: 147-375
Range on HMM: 41-275/315.0
KNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKGTKP--MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQV
.. .|||||||..   |..||.|    |    ||. | |.|. .    .| .||||| .  | ||||||| |..| |. .. |. . ||  |.|| ... 
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

LTFGEITVTCTESTTPDNHTQLKMltVMdKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLR----KMPGPIVVHCSAGIGRTGTFAAIEVGAQCL
  ||.| |.  .  .  . .. |.  |. .|| .|...  ..   |||| .     ..|. .. ..    |   ...||||||.|||| . .|.   . .
vefGsikvellsleadtdgvarkl..vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqi

LNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
 ....    ..|. .|  |   || . .| .. .|.|.
krtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 145-376 5.1e-42 138.8 In-house 32-269 (285) alignment 
Range on Protein: 145-376
Range on HMM: 32-269/285.0
FDKNTEfkKNRYKDVPCNDKTRVILKDgYPGDYVHANYVKG---TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQV
.. | .   ||| || | ..|||.||. .  ||.||....     .  .| ||||| .|  |.|.|. || .| . ||| |.| |  ||  |.|.  |.|
yeanpd..lnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

LTFGEITVTCTESTTP-DNHTQLKMLTVMDKKSGKSHKLY--HYKIITWPDKSIALSNLAILRTLRSLRK---MPGPIVVHCSAGIGRTGTFAAIEVGAQ
. ||.  .| ||        | |. |||.. .   |  ||  | ..  |||.        ..   . ..|      ||.||||||.||| ||  |.  . 
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

CLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
 ...       |.|| .|  |...||   |.|.|   ... 
rimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Ptp69D_pd Subfamily Ptp69D 146-378 5.3e-42 139.0 In-house 44-287 (307) alignment 
Range on Protein: 146-378
Range on HMM: 44-287/307.0
DKNTEFKKNRYKDVPCNDKTRVILKDG---YPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTegQ
.|.    ||||.|.   |||||.||        ||. |...||   |  ||  |.|.  |. | |||. .  |  | || .| |  | ||. |.|.   .
ekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..d

VLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSG----KSHKLYHYKIITWPDKSIALSNLAILRTLRSL----RKMPGPIVVHCSAGIGRTGTFAAIEV
   .|.| |.. .. . ..... ..   . |...    .|.|.  |.  .|.|  .  .  ..|. .. .    ..  .||||||||| ||.|.| |...
evqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

GAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLGV
  | | . .     . |. .|. |   ||   ||  |  |.||   
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRA_pd Subfamily PTPRA 145-376 5.6e-42 138.8 In-house 53-294 (330) alignment 
Range on Protein: 145-376
Range on HMM: 53-294/330.0
FDKNTEFKKNRYKDVPCNDKTRVIL--KDGYP-GDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDtEG
 .|. . .|||. ..  .| .||||  |.| .  ||. | ...|   |  || .|||...|  | |||. .   |.| || || |  . ||. |.|| ||
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd.eG

qVLTFGEITVTCTESTTPDNHTQLKMLTV--MDKK-SGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK----MPGPIVVHCSAGIGRTGTFAAIEV
 ..|.|.|.|.  ..|   . |  |.|     |..   ||  .  ..  .|||  .      .|. |. ..|    . ||||||||||.|||||| ... 
.lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda

GAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
  . .   .     . |. .|  | . || | || .. ...|. 
vlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 143-375 3.7e-41 135.8 In-house 36-274 (515) alignment 
Range on Protein: 143-375
Range on HMM: 36-274/515.0
SIFDKNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKGTKP--MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDT
.. ... .|||||||..   |..||.|   .|    ||. | |... .    .| .|||.| .  | ||.|||| |..| |. .| |. . ||  |.|| 
tvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdk

EGQVLTFGEITVTCTeSTTPDNHTQLKMLTVMdkKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL----RKMPGPIVVHCSAGIGRTGTFAAIEVG
 |. . ||.| |    |.  .  .  . |||.  |. .|. .  ..   |||| .     ..|. .. .     ..  |...|||||.|||| . .|.  
pgdsvkfGsikvelv.sleactggikrkltvl..kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsv

AQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
     ....    ..|. .|  |   || . || .. .|.|.
vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 152-376 4.7e-41 135.7 In-house 49-277 (287) alignment 
Range on Protein: 152-376
Range on HMM: 49-277/287.0
KKNRYKDVPCNDKTRVILKdGYPGDYVHANYVKGTK--PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGqvLTFGEITV
.|||....   |. ||.|| |   ||. | ...| |    ||....|. .|| . |... .. | || |||.. || . .|  |.|...   ...|| ..
dknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyni

TCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKS----IALSNLAILRTLRSLRK-MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFR
. .. .. .. .. |.    ..|.|. ...  |.| .|...      . . | | .  .. ||   ..||||||...||...| |.... .   .  .  
ellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviD

PADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
  ....  |  . .|||  .|| ......|  
vfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 147-376 5.8e-41 135.4 In-house 46-278 (315) alignment 
Range on Protein: 147-376
Range on HMM: 46-278/315.0
KNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTegqV
|  . .|||| ..   ||.|| |   .     ||| ||...|   | ..| .|||.  .  | ||.| .| .. | || .|.|. . |.| |.||     
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...k

LTFGEITVTCTESTTPDNHTQLKMlTVMDKKsgKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK----MPGPIVVHCSAGIGRTGTFAAIEVGAQCL
...|.||||  .    .. |   . .|. ..  . .... ... .|||  .. . ....   |  ..      |.||||||||.|||||| ...   . .
viyGkitvtrkseevnteytvrtl.svvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

LNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
   .|    .... ||. | . ||.  || .. .|.|. 
eaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN1_pd Subfamily PTPN1 149-375 7.2e-41 134.8 In-house 31-269 (290) alignment 
Range on Protein: 149-375
Range on HMM: 31-269/290.0
TEFKKNRYKDVPCNDKTRVILKDGYPgDYVHANYVK--GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEG-QVLTFG
.. ..|||.||   |..|..|...   ||. |. |.    |  .||||||| .|.   |.|| ..   |. || ...|... ||  |.|  |  . |.. 
enrnlnryrdvspydhsrikleradn.dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellle

EIT--VTCTESTTPDNHtQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLR------SLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCL
...  |.  .  . ... ....| . ..|. ......|.. .|||| ..  |  | |. |       || .  || |.||||||||.|||. ..     .
dtklkvkliseerksyy.tvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvli

LNGKAFRPAD---LVRAVRHCRLNSVQMDTQYLMLVEAILD
 . .     |    . ..|. ||  .|   |  .   |||.
ekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0051429 (Phosphotyrosine protein) phosphatases II 175-377 1.4e-40 135.0 In-house 4-225 (272) alignment 
Range on Protein: 175-377
Range on HMM: 4-225/272.0
GDYVHANYVKGTkPM------FILTQGPLKDTAMDIWRMvLQEGVAAICMLCELIENGRPKCEPYFP----------DTEGQVLTFGEITVTCTESTTPD
..|..|..|.|          .....|||. || |.||.  ..|. .|..|... | || ||..| |          |.. .  ..| ..||... .. .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

NHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNlaILRTLRSLRKmPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFR--------PADLVR
...  ..| ..  . |......|.  . ||| ... .   .|. |. |.. .||..||||||..||||..|.   .. .     .         ... |.
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

AVRHCRLNSVQMDTQYLMLVEAILDLG
 .| .| ..|| ..|||.| ||.|.| 
elraqrpgavqteeqylflyeallell
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 100-370 3e-40 132.7 In-house 6-283 (310) alignment 
Range on Protein: 100-370
Range on HMM: 6-283/310.0
RHSVQTEAFETFTTTVTSMGVDGLAKEYLETLVPFLPVGYFErsIFDKNteFKKNRYKDVPCNDKTRVILK--DGYPGDYVHANYVKGT--KPMFILTQG
.|    .|.| |  .   .|..||.|.|        .   .|   . |.  ..|||| || | |..|| ||      .||.||||||    .  || .||
hhlkylkalenfiiateklgieglvkqyrkldakqdssltye..aykky..mhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqg

PLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTeGQVLTFGEITVTC-TESTTPDNHTQLKMLTVMDKK-----SG--KSHKLYHYKIITW
||. | .|.|||..||   .| .||   |.|||||  |.|   |   |.| | ||  .||.   .  .| .  | |.          |  ..   |   |
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnw

PDKSIALSNLAIL--RTLRSLRKmpGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLV
||. .   .   .  | |  .|.  || |||||||..|... .|...  . | .|.     ...  ... |.  .| . |||.. 
pdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 143-376 1.1e-39 131.3 In-house 44-283 (297) alignment 
Range on Protein: 143-376
Range on HMM: 44-283/297.0
SIFDKNTEFKKNRYKDVPCNDKTRVILKDGY---PGDYVHANYVKGTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRpKCEPYFPDTeg
   .|. .|.|.|||..   |. ||.|.        ||| | .||| |  .| || | |.|  | |.|||.| |..| || .. |. . ||  |..|.  
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk..

QVLTFGEITVTcTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIAL--SNLAILRTLRSLRK-----MPGPIVVHCSAGIGRTGTFAAIEV
 | |||...|. ..|..  .    . |.|   |. . . .  |. . ||||..    |  ..|  .  .||       ||..|||.||.|||| . .|. 
gvttfGdvsvv.llsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

GAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILDL
      . |.    .||. .|. | . || . || .. .|.|. 
vvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 147-375 2.6e-39 129.8 In-house 30-264 (283) alignment 
Range on Protein: 147-375
Range on HMM: 30-264/283.0
KNTEFKKNRYKDVPCNDKTRVILKDGYPgDYVHANYVK-----GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDtEGQv
 . . .|||....   |. || ||   . ||. | ..        .  .| .|.||..| .| |.|| .| ..|| || .| |. | ||  |.|  .|  
adenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk.rGs.

LTFGEITVTCTESTTPDNhTQLKMLTVMDKKSGKSHKL-YHYKIITWpdksIALSNLAILRTL------RSL--RKMPGPIVVHCSAGIGRTGTFAAIEV
  .|| |||  . || .     | |..  . | ||  |  ||..| |    .  .. ||. .|      .||  ..  ||||||||.|||||..| |. .
edyGeftvtlrkettsns.fiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasa

GAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
  . .|          |. .|  |   ||   || .. |..|.
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 152-373 4.2e-39 129.1 In-house 52-278 (301) alignment 
Range on Protein: 152-373
Range on HMM: 52-278/301.0
KKNRYKDVPCNDKTRV-ILKDGYpGDYVHANYVK--GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEIT
.|.||. |||. .| | ...||     .|||...  |    || ||||||.|. | | |. |  |  | ||.. .|.   ||| |.| . .. |  |  .
dkhryptvPckPstavevivdGk.rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfk

VTC--TESTTPDNHTQlKMLTVMDK-KSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRP
..   .|.   .. .. . | | |  .  ... . ||.  .|.|. .  |   .   .  ..|   ||||||||||||. .| . |. |. ... .    
ikiknkelilnkkisk.rtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptiel

ADLVRAVRHCRLNSVQMDTQ-YLMLVEAI
.. .. .|. | |.||. .| | | . ..
tealkhlrehrwngvqtnsqlywmtlGtv
0041856 (Phosphotyrosine protein) phosphatases II 151-375 6.8e-39 128.7 In-house 2-169 (182) alignment 
Range on Protein: 151-375
Range on HMM: 2-169/182.0
FKKNRYKDVPCNDKTRvilkdgyPGDYVHANYVKGTKPM--FILTQGPLKDTAMDIWRMVLQEGVAAICMLCeliengrpkCEPYFPDTEgqvltfgeit
..||||.|....| .|       . ||..||.. |  |   ||.|||||..|  | .||. ..|. .| .|.         .|.|.|. .          
ldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell..........

vtctesttpdnhtqlkmltvmdkksgkSHKLYHYKIITWPDKSIALsNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCllngkAFRPADL
                            .  ..|. . ||| ..      .|. ..  .. .||..||||||.|||||..|. .  ..      . . . 
...........................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleea

VRAVRHCRLNSVQMDTQYLMLVEAILD
|. || .| ..|..  || .|  |.|.
vklvrsrRpgmvitpnqyfflqlalle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 152-377 9.8e-38 124.6 In-house 44-276 (312) alignment 
Range on Protein: 152-377
Range on HMM: 44-276/312.0
K-KNRYKDVPCNDKTRVILKdGYPGDYVHANYVK-GTKPM-FILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLT--FGE
|  ||| .. | |. |  |  |    |.|||.||  |||  |. |||||..|.  .|...|  | ..| .|| ..|.|  ||  |  |  | |       
kdlnrypniqcwdrgrftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

ITVTCTESTT---PDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAF
 |  |||        ..   ..| |. | .|.  || ||.  .|||. .  |  . || | ...|   |.. |||||.|||||.| ||    .|   .  
yteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkq

RPADLVRAVRHCRLNSVQMDTQYLMLVEAILDLG
   |    .|. |  ||..  ||.. . ..|.. 
nvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 152-374 6.1e-36 118.8 In-house 5-236 (237) alignment 
Range on Protein: 152-374
Range on HMM: 5-236/237.0
KKNRYKDVPCNDKTRVILKD-GYPGDYVHANYVK---GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEgQVLTFGEI
 |||| .. . |..||.||  |   ||. |.|.|   ||   .| .||||. .  |.|.|| ||  . | ||  |||. . ||  |.|.|. |  ..| .
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaaygvl

TVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLR----K--MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGK
||. .      ..|   .|...  .  .   .. |.. .|||. .     |.||  . .     .    || ..|||||.|||| |  |.   .   . |
tvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk

AFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
     . | ..   |   .|   ||... ..||
vvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-374 2.9e-35 116.4 In-house 38-274 (287) alignment 
Range on Protein: 150-374
Range on HMM: 38-274/287.0
EFKKNRYKDVPCNDKTRVILKD--GYPGDYVHANYVKGT--KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTeGQVLTFG
. ||||| ||   |.|||.|     .  ||. |||| .   .  || .|||.  |  | ||.||.. .|.. ..   .|..| ||  |.|.   . .  |
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvG

EITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL-------R--KMPGPIVVHCSAGIGRTGTFAAIEVGAQC
  .|.  . .  . .   . | ..| .. ... .  .....||||..| . ....|   .        |  .  ||.|||...||||.|.. |. |  . 
GysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr

LLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
|..     .|  |  .|  |   ||   |. .|.||. 
ledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 153-396 3.3e-35 116.7 In-house 22-264 (290) alignment 
Range on Protein: 153-396
Range on HMM: 22-264/290.0
KNRyKDVPCNDKTRVILKD---GYPGDYVHANYVKGTKP-MFILTQGPLKDT-------AMDIWRMVLQEGVAAICMLCELIENGRP----KCEPYFPDT
..|  .||   .|||.||.    .  ||.|||.|.  .   .|||| |....         . | |. || |  . ||||  |. .      |. |.|..
dqR.levpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

EGQVLTFGEITVTCTESTTPDNHTQlKMLTV-MDKksGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQC
.|. |.|. .|| |..  . |.  . . |.|  |.  .. ... |...  | . ..  ... .|  .. ...   |..|||  || |  ..|||..| | 
vgeelkfkgltvkCkskekeddvet.Relvvkfdd..eeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQk

LL-NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILdlgvafkyiedpksLDAIETYK
.    ...  .|.. |.|. | . .. ....   . .|.              | |||...
iaetsgsvkledvlkalrkqralaitsalelafvdagiv..............llaievld
subfamily_egg_pd Subfamily egg 150-404 1.1e-34 114.5 In-house 40-293 (307) alignment 
Range on Protein: 150-404
Range on HMM: 40-293/307.0
EFKKNRYKDVPCNDKTRVILK---DGYPGDYVHANYVKGTKP--MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENgrPKCEPYFPDTEGQVLTF
. .| | | |.|.| .|| |.     | .|..|||.|||      |||.| |||.|  | |||| || |  | ||    |.   .|| |.| .| . | .
nlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvt

--GEITVTCTES-TTPDNHTQLKMLTVMDKKSGKSHkLYHYKiITWPDKSIALSNLAILrtlRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGK
  | . ... .   ..|   ..  | ..  .  . . | |..   .   |   | | .|   | ||..  |.||..  |. ...|. |||.    || | 
vpGslrienlkvdskadplfrvtklklvGgddeerf.lehwq.gdvnnssdvysplrvl...rklrnlskpvvvqdilGvskaatlvaieiallsllrGp

AFRpADLVRA---VRHCRLNSVQMDTQYLMLVEAILDLgvAFKYIEDPKSLDAieTYKRNVADYVE
 ..   . ||   .|  |  ||.   .||..   .| .      |   | ||    |.| . ...|
itk.slvlravvflrlrrrlsvesvllylfvyrlvlff..frdvigsakeldv..dyerwleerse
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 146-373 4.7e-34 112.5 In-house 36-289 (301) alignment 
Range on Protein: 146-373
Range on HMM: 36-289/301.0
DKNTEFKKNRYKDVPCNDKTRVILKDG-----YPGDYVHANYVKGTK--PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTE
 .... . ||.|..   |. |.|||          .|. |.|..|..    || .|||.| | .|.||...|| ...| |...| |. . ||| |.|..|
lseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnse

GQVLTFGEITVTCTEST-TPD---------------NHTQLKMLTVMDKKsgKSHKLYHYKIITWPDKSIALSNLAILRTL-----RSLRKMPGPIVVHC
 .  .||..||| ....  ||               |    ... |  .|  .|...  .... ||.  .      .|. .     |  .   ||.||||
aeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHC

SAGIGRTGTFAAIEVGA-QCLLNGkAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAI
|....|.|.. ....|  ||  .|      ....|||. .   |.   || .. ..|
SdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 143-375 5.9e-34 112.3 In-house 41-277 (439) alignment 
Range on Protein: 143-375
Range on HMM: 41-277/439.0
SIFDKNTEFKKNRYKDVPCNDKTRVIL--KDGYP-GDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRpkcepYFPdT
|.  .. .  |||||||   | |||.|    | |   |. |||.||  .. ..| |||| |.|. | ||.|... .. | ||..|.|  .     |.| .
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywp.s

EGQVlTFGEITVTCTESTTPDNHTqLKMLTVMDKK--SGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL-----RKMPGPIVVHCSAGIGRTGTFAAI
...|  .|.|.| .       |.. .. . |....  . | . . ... |.|||| .      .|  ||..     ..  ||.|||||||.|||||  |.
daev.cygdiavrvdrnielpnyv.irgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiial

EVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
..  . |   .      .|. .|. | . ||   ||... .|.|.
dialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0046846 (Phosphotyrosine protein) phosphatases II 170-373 6.9e-34 112.5 In-house 7-169 (176) alignment 
Range on Protein: 170-373
Range on HMM: 7-169/176.0
KDGYPGDYVHANYVKGTkpMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLtfgeitvtctesttpdnhtqlkmltvm
 .... ||..||.. |   ..| ||||| .| .| ..|....|. |. .|.|..| || ||  |.|. |.  .                           
gldldldyinanlilgs..rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

dkksgkshklyHYKIITWPDKSIALSnLAILRTLRSLRKMP---GPIVVHCSAGIGRTGTFAAIEvgaqCLLNGKAFRPADLVRAVRHCRL-NSVQMDTQ
           .|. . ||| ..  .  ..|. |. .|..    ||..||||||||||||..|.      |  .| . . . .. || .|  ..|| . |
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YLMLVEAI
| .| |..
yrflyefe
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 121-375 7.3e-34 112.3 In-house 23-286 (325) alignment 
Range on Protein: 121-375
Range on HMM: 23-286/325.0
DGLAKEYleTLVPflPVGYFERSIFDKNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGvAA
||.|.|.   |.|  ...   . .  |  . .|||.|.|   ||.||.|   ||    ||. |.|..    | .|. .| || .|  |.||.||.   ..
dgfahef..gllp..sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.cs

ICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTESTTPDNHTQlKMLTVMDKKSGKSHKLYHYKIITWPDKSI---ALSNLAILRT-------LRS
. .. . ...|  .|  |.|.  |.  ||| . |      .  .. . ..| | . | |..  .  ... .|.|        . ..||..       ...
vvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvh.rvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

LRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
  |  .||.||||||.||||.|...   .. ...       . |. .|. | . |.   || .. ||. .
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 152-375 5.7e-32 106.3 In-house 63-289 (319) alignment 
Range on Protein: 152-375
Range on HMM: 63-289/319.0
KKNRYKDVPCNDKTRVILK--DGYP-GDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCeliengRPKCEPYFPDTEGQVLTFGE
 |||. ..   ||..| |.  .|    ||. | .|.|   | ..| .||||..|  | |||. .  ...| .|       . ||  |.|    .    ..
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfk

ITVTCTESTTPdnHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRT------LRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNG
. |.  | |    ..  ..    | |     |.  ...  |||.    .   ..|       |.|  . . .||||||||.||||.. ...|  . . . 
vkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee

KAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
|     ..|| .|  | . ||  .|| ..  |.|.
kqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 152-375 8.4e-32 105.8 In-house 27-253 (284) alignment 
Range on Protein: 152-375
Range on HMM: 27-253/284.0
KKNRYKDVPCNDKTRVILK--DGYP-GDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCeliengRPKCEPYFPDTEGQVLTFGE
 |||. ..   ||..| |.  .|    ||. | ...|   | ..| |||||..|  | |||. .  ...| .|       . ||  |.|    .    ..
dknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfk

ITVTCTESTTPdnHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRT------LRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNG
. |.  | .    ..  ..    | |  .  |.  ...  |||.    ..  ..|       |.|  . . .||||||||.||||.. ...|  . . . 
vkvdsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkee

KAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
|     ..|| .|  | . ||  .|| ..  |.|.
kqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0049772 (Phosphotyrosine protein) phosphatases II 143-374 9.7e-32 106.3 In-house 39-277 (314) alignment 
Range on Protein: 143-374
Range on HMM: 39-277/314.0
SIFDKNTEFKKNRYKDVPCNDkTRVILkDGYP---GDYVHANYVKGTkPMFILTQGPLKDTAMDI----------WRMVL--QEGVAAICM---------
 ..|.    .||||.|... | .|||| .|.|    || .|.||.|    || |||||. |  |.          |||||  .  |  | |         
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LCELIENGrpkcepyfpdtegQ--------VLTfgeitvtctesttpdnhtqlkmlTVMDKKSGKSHKLYHYKIITWPDkSIALSNLA
            |..| .||                       |                        .... ..  ..  ..|. | .||   | .   
lsrLdaAlgKtpllildgng.............neptaadlellk.......................eelydpelferlgikylripvpD.gsaplled

ILRTLRSLRK--MPGPIVVHCSAGIGRTGTFAAIEVgaqCLLNGKAfRPADLVRAVRHCRL-----NSVQMDTQYLMLVEAIL
... |. ...   .||..|||.||.||||||...     ...  .   ... .. || .|      .....  ||..  ||.|
fdeflefieeadkggpvlvHCkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfieqleqyefileall
subfamily_PTPN14_pd Subfamily PTPN14 149-373 1.4e-31 104.6 In-house 48-292 (300) alignment 
Range on Protein: 149-373
Range on HMM: 48-292/300.0
TEFKKNRYKDVPCNDKTRVILKDG--YPGDYVHANYVK----GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDT--EGQ
 . .|||.|||   ...|| |.       .|. |  .|    |..  .| .||||. |  | |.|| ..||. | || | .|.|. |.  |||..  . .
enaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkk

VLTFGEITVTCTESTTPDNHTqLKMLTVMDKKSGKSHKLYHYKIITWPDKSIAL---SNLAILRTLRSLRKM----------PGPIVVHCSAGIGRTGTF
 ..||.  ||   |.. |  .  . |..    |..  ...| . . |||. .     . |  |. ..|.|.             |..||||||.||||  
tvefgkfkvttkfsedsdsvi.ttglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvl

AAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAI
   ..  ..| ...       .. .|. |   ||  .|| .. ...
ilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvl
0036282 (Phosphotyrosine protein) phosphatases II 175-370 1.5e-31 104.8 In-house 2-163 (174) alignment 
Range on Protein: 175-370
Range on HMM: 2-163/174.0
GDYVHANYVKGTK--PMFILTQGPLKdtamdIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDtegqvltfgeitvtctesttpdnhtqlkmltvmdKK
 || .|......   | .|..||||.      |.|. ..|. .. ||.|..|.|. ||  |.|.                                  ..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

SGKSHKLYHYKIITWPDKSIALSNLaILRTLRSLRKM-----PGPIVVHCSAGIGRTGTFAAIEVGAQCLLnGKAFRPADLVRAVRHCRLNSVQMDTQYL
.  ..  ..|. . ||| .   ..  .|. .. ...       ||..||||||.|||||..|.    ..||  ..    ||||..| .| ..||.. || 
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

MLV
 | 
fly
0043147 (Phosphotyrosine protein) phosphatases II 175-370 9.4e-31 102.2 In-house 5-154 (172) alignment 
Range on Protein: 175-370
Range on HMM: 5-154/172.0
GDYVHANYVKGTKPM--FILTQGPLKDTAMDIWRMVLQEGVAAICMLCELiengrpkcepyfpdtegqvltfgeitvtctesttpdnhtqlkmltvMDKK
 ||..|.|....  .  || |||||  |  | |||. ..|. .| .|.||                                              .  .
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lydp

SGKSHKLYHYKIITWPDKSIAlSNLAILRTLRSLRK-----MPGPIVVHCSAGIGRTGTFAAIEVGAqcllngKAFRPADLVRAVRHCRLNSVQMDTQYL
.. ..  ..|  . ||| .   .   .|..|. ...       ||..||||||.|||||..|.          . . . . |. ||..| ..|| . || 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

MLV
 | 
fly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 149-375 1.5e-30 101.1 In-house 6-238 (239) alignment 
Range on Protein: 149-375
Range on HMM: 6-238/239.0
TEFKKNRYKDVPCNDKTRVILKD---GYPGDYVHANYVK---GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVL
 .  |||| ..   |..||.|.        ||. |.|..   |.   .| ||| .. .. |.|||. ||  . | ||  |||  . ||  |.||.  .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

TFgEITVTCTESTTpDNhtQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK--MPG--PIVVHCSAGIGRTGTFAAIEVGAQCLL
 .  .|.  ||  . |    .. . . .    . . .|.|..  |||| .     |.|   | . |  .||  | |.|||||.||||.|  |.   .   
nl.rvtlrktevfa.dy..iirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
. |.    . |.|.|  |   ||   ||...  |.|.
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 149-374 1.8e-30 100.9 In-house 7-238 (239) alignment 
Range on Protein: 149-374
Range on HMM: 7-238/239.0
TEFKKNRYKDVPCNDKTRVILKD---GYPGDYVHANYVK---GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVL
 .  |||| ..   |..||.|.        ||. |.|..   |.   .| ||| .. .. |.|||. ||  . | ||  |||  . ||  |.||.  .  
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskyc

TFgEITVTCTESTTpDNhtQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRK--MPG--PIVVHCSAGIGRTGTFAAIEVGAQCLL
 .  .|.  ||  . |    .. . . .    . . .|.|..  |||| .     |.|   | . |  .||  | |.|||||.||||.|  |.   .   
nl.rvtlrktevfa.dy..iirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

NGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
. |.    . |.|.|  |   ||   ||...  |.|
kqktvdifnyvkairedrphmvqtseqyvfihlavl
0049260 (Phosphotyrosine protein) phosphatases II 189-370 4.2e-29 96.6 In-house 10-143 (152) alignment 
Range on Protein: 189-370
Range on HMM: 10-143/152.0
MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFpdtegqvltfgeitvtctesttpdnhtqlkmltvmdkksgkshklyHYKIITWP
.|| ||||.  |. | |||. . |. .| ||.|| |.|..||| |.                                              .|. . ||
efiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlpwp

DKSIALSNLAILRTLRS----LRKMPGPIVVHCSAGIGRTGTFAAIEVGAqcllngKAFRPADLVRAVRHCRLNSVQMDTQYLMLV
| .   .   .|  |.     ...  ||..||||||.|||||..|.          . . . . |. || .| ..|.   |.  | 
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 146-293 1.9e-28 94.2 In-house 29-180 (297) alignment 
Range on Protein: 146-293
Range on HMM: 29-180/297.0
DKNTEFKKNRYKDVPCNDKTRVILKDGYPG-DYVHANYVKG----TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQ
 .|. ..||||.|.   |.||| |. . .. ||. |.||      ..  .||.||||..|  | |..| ...| .| |...| |.|| || ||.|.....
krnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

VLTFGEITVTCTESTTPDnHTQL--KMLTVMDKksGKSHKLYHYKIITWPDKSIA
 |. |.. |    ||. . . ..    |... .   .| .. | . ..|||. . 
rlkagdvvveflsstsde.fdrviltelqliyr..sesrvvrhvqflswpdhGvp
0051082 (Phosphotyrosine protein) phosphatases II 176-371 8.8e-28 92.2 In-house 4-147 (151) alignment 
Range on Protein: 176-371
Range on HMM: 4-147/151.0
DYVHANYVKGTkpmFILTQGPLKdtamDIWRMVLQEGVAAICMLCELIENGrpKCEPYFPDTEgqvltfgeitvtctesttpdnhtqlkmltvmdkksgk
|| ...|| |    .....|||     | .... ..|. .|..|... |.|  .|  |.|...                                     
dyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.....................................

sHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM-PGPIVVHCSAGIGRTGTFAAIEVGAQCllngkaFRPADLVRAVRHCRLNSVQMDTQYLMLVE
 ....|. |. ||| .. ||  |.|. |. |... .||..||||||.|||||..|.   ..       . ... .. .| .| ..||  .|.|..  
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_PTPRN_pd Subfamily PTPRN 147-368 3.7e-27 89.8 In-house 53-283 (297) alignment 
Range on Protein: 147-368
Range on HMM: 53-283/297.0
KNTEFKKNRYKDVPCNDKTRVILKDG---YPGDYVHANYVKGT---KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQ
..   ||||.|.|   |..|| ||.       ||. |  .  .   .|..| ||||| .|  |.|.|| ..||. | .|..| |.|  .|. |.||.  .
aeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse

VLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYkiITWPDKSIALSNLAILRTLR----SLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQC
|  . |. .      . |   .   |  ....  ..   .|.  ..||....  |  ..|   |    | |    |||||||.| ||||.. .|..  . 
vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhf..lswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnr

LLNGkaFRPADLVRAVRHCR---LNSVQMDTQYLM
||.|   .  |.. .. | |    . |.   |. .
llkG..vkeidiaatlehlrdqrpglvktkdqfef
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 143-375 1.6e-26 87.9 In-house 28-257 (267) alignment 
Range on Protein: 143-375
Range on HMM: 28-257/267.0
SIFDKNTEFkkNRYKDVPCNDKTRVILKDGYpGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKcepYFPDTEGQ
||  || |.  ||. |.   |.|||||..    .|. | ||.|  || .||.||.||| |  | . .. ...|. | .|    ..  ..   ..|   ||
siaeknqer..nrlddnlpyddtrvilrtke.eeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPkmgq

VLTFGEITVTCTESTTpDNHTQLKMLTV-MDKKSGKSHKLYHYKII--TWPDKSIaLSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCL
   . ..||  .     .|  |.  | . . ..| .   ||.||       .|   |  |  . .   | .   |.||.||.|.||.|||  |.   . .
akkyqdltvehsleke.endyqiitlelkfknesahnvtlyyykkwnintnnkpy.lkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera

LNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
 .       |..| .|. |   |.   .|. . | . .
ktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 143-375 4e-26 86.3 In-house 38-234 (392) alignment 
Range on Protein: 143-375
Range on HMM: 38-234/392.0
SIFDKNTEFKKNRYKDVPCNDKTRVIL---KDGYPGDYVHANYVKGTKP--MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGrpkcepyfpdt
..  |. . ||||||..   |..||.|    |    ||. | |... .    .| .|||   .  |.||||.|| |..|.|. .| |             
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

egqvltfgeitvtctesttpdnhtqlkmltvmdkKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM----PGPIVVHCSAGIGRTGTFAAIEVG
                                  |  . .    ...  |||| .     ..|. .. ..        |...|||||.||||   .|.  
..................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsv

AQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
     . .     ..|  .|. |   || . || ..  |.|.
vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
0044763 (Phosphotyrosine protein) phosphatases II 173-372 4e-26 87.2 In-house 16-166 (178) alignment 
Range on Protein: 173-372
Range on HMM: 16-166/178.0
YPGDYVHANYVKGTkpmFILTQGPLkdtaMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGqvltfgeitvtctesttpdnhtqlkmltvmdkk
  .|| .|... .    ..|.. |      | .... ..|. .|..|.| .|.|..|| ||.|. .|                                 
ersdyinaseilpg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................................

sgkshklYHYKIITWPDKSIALSNLAILRTLRSLR----KMPGPIVVHCSAGIGRTGTFAAIEVGAQCllngkAFRPADLVRAVRHCRLnSVQMDTQYLM
       ..|. | .|| .   .   .|.... ..    . .||..||||||.||.||..|.    ..      . . . .. || .|   |. . |.  
.......iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq

LVEA
| | 
Lyef
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 195-370 4.3e-25 82.8 In-house 98-281 (302) alignment 
Range on Protein: 195-370
Range on HMM: 98-281/302.0
GPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTES-TTPDNHTQLKML---TVMDKKSGKSHK-LYHYKI---IT
 | |.|    | .. |  || .  ||...|..  || .|. |  |..|.||. ||.  .  |  .. |  | .   ||  | . | .|  .  .|    .
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDKSIALSNLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLV
|||.       . |  |.        ..||||||.|||||. ||  | |  .. |    ...|  ||.||  .|| ..| . |.
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_ptpA1_pd Subfamily ptpA1 137-330 7.7e-25 82.5 In-house 34-249 (418) alignment 
Range on Protein: 137-330
Range on HMM: 34-249/418.0
VGYFERSIFDKNTEFKKNRYKDVPCNDKTRVILK---DGYPGDYVHANYVKGTKP-MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEP
||  | |  ||. .  |||| ..   ..||| ||   |    ||. |||. |. |  || ||||| .|  |.|||| .. .  | ||    || | ||. 
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

YFPDTEG--QVLT-------FGEITVTCTESTtPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLR-----KMP-----GPI
|.|.  |  |.         ||  .|   |    |   ..    .     |... . .|.   |||. |      . . |.|.       .|      ||
ywpeqiggeqfsiygngnevfgtysvelvevi.qdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

VVHCSAGIGRTGTFAAI
.||||||.||||||.. 
ivhcsagvgrtgtfcta
subfamily_CG7180_pd Subfamily CG7180 147-375 2.2e-24 80.6 In-house 39-288 (296) alignment 
Range on Protein: 147-375
Range on HMM: 39-288/296.0
KNTEFKKNRYKDVPCNDKTRVILKD--G-YPGDYVHANYVKG-TK-PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRpKCEPYFPDTEgqV
...  .|||. .|   |..||.|.   |    ||. | || . .|   .| |..| |.|  . ||.| .|.. |. .|..  .  . ..  |.| .    
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..k

LTFGEITVTCTESTTPDNHTQlKMLTVMDK----------KSGKSHKLYHYKIITWPD-KSIALS---NLAILRTLRSLRKMP------GPIVVHCSAGI
  .||| |  .|. .  | .. ... .. |           . .   . .... .|.  ... ||    . ..|  |..|.        ||.||..| | 
eqygeifveiveekqyanlki.rtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGa

GRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAILD
.|.| . ||..  . . . . .   . |. .|. | . |.. ..|  . . .|.
sRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
PTPc_DSPc_SM00012 279-374 2.9e-24 80.7 In-house 2-104 (105) alignment 
Range on Protein: 279-374
Range on HMM: 2-104/105.0
LYHYKIITWPDKSIALSNLAILRTLRSLRKMPG------PIVVHCSAGIGRTGTFAAIEVGAQCLLNG-KAFRPADLVRAVRHCRLNSVQMDTQYLMLVE
..||.. .|||...  .  .||..||...|         |.|||||||.||||||.|...  | | .. | .   ..|...|. | ..||...|||.| .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AIL
|.|
all
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 192-338 7.1e-24 79.3 In-house 39-176 (255) alignment 
Range on Protein: 192-338
Range on HMM: 39-176/255.0
LtqgplkdTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKkSGKSHKLYHYKIITWPDKS
|       |    .... | .   . |||.. |.|. ||. |||    . | . ...||.|.|..      |.... . .   | |.. ||.   |..| 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge.kkkthtvkhysykGWiekn

IALSNLAILRTLRSLRKMpGPIVVHCSAGIGRTGTFAAIEVGAQCLL
       ||  |.  |.   ..|||||.||||. .|. .|.  | ..
aPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmi
subfamily_hpo-7_pd Subfamily hpo-7 189-337 5e-23 76.3 In-house 39-181 (263) alignment 
Range on Protein: 189-337
Range on HMM: 39-181/263.0
MFILtqgpLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTESTTpDNHT-QLKMLTVMDKkSGKSHKLYHYKIITW
...|    | .|   ..... | .   . |||.  |.|. ||. |||    . . . ...|..|..   |     |..| ....   | |.. ||.   |
lysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlge.KkkthtvkhysykgW

PDKSIALSNLAILRTLRSLRKMpGPIVVHCSAGIGRTGTFAAIEVGAQCL
..|        ||. |.  |.   ..|||||.||||.  |. .|.  | .
iekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 144-373 5.2e-23 75.9 In-house 47-281 (302) alignment 
Range on Protein: 144-373
Range on HMM: 47-281/302.0
IFDKNTefKKNRYKDVPCNDKTRVILKdGYPGDYVHANYVKGT--KPMFILTQGPLKDTA---MDIWRMVLQEGVAAICMLCELIENGRpKCEPYFPDTE
.| ||.  |||. .|||. |...|.|. . | .||.|  |.    ..  ||.| | .|..    . |||| || .. . .|    |  .   . .|| . 
afkknl..kknqsedvpildsnlvkle.aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkks

GQVLTFGEITVTCTESTTPDNHTQLKMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSL----RKMPGPIVVHCSAGIGRTGTFAAIEVGA
|. ...|.. |        .....  .. |. .    |     | .  |..|..  .  .. .|  ..     |   ..|.    |.|| |.| .  |  
gdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavav

QCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAI
..| .||. . ...|...|  | ..|.  .|| .|  |.
eklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 128-380 4.4e-22 73.1 In-house 28-286 (303) alignment 
Range on Protein: 128-380
Range on HMM: 28-286/303.0
LETLVPFLPVGyFERSIFDKNteFKKNRYKDVPCNDKTRVILKDGypgDYVHANYVK-GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENG
.| .| .||     .  | ||  ..|||. || | |...| | |     |.||.|..  ..   |||| ||  || |.|.|.... |  . .|    |  
fekvvsylpps.vsknqfvkn..mdknrfvdvicldhskvklsds...syihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseyd

RPKCEPYFPDTEgQVLTFGEITVTCTESTTP--DNHTQLKMLTVMDKKSGKSHKLYHYKiiTWPDKSIALS-----NLAILRTLRSLRKMP--GPIVVHC
.   .  ||  . . | | | ..   |       .  .||.|.| . .     ...|||  .|| .||           | .    |||     | |   
klggdsvfprnq.dflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvyms

SAGIGRTGTFAAIEVGAQCLLNGKAF-RPADLVRAVRHCRLNSVQMDTQ----YLMLVEAILDLGVAF
 .| ||.|||| .|     | . .|       .  ||  || .||  .|    | .| | .|| |.. 
lsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngick
0048076 (Phosphotyrosine protein) phosphatases II 264-373 1.6e-18 62.2 In-house 32-139 (145) alignment 
Range on Protein: 264-373
Range on HMM: 32-139/145.0
KMLTVMDKKSGKSHKLYHYKIITWPDKSIALSNLAILRTLRSLRKM---PGPIVVHCSAGIGRTGTFAAIEVGAQcllNGkaFRPADLVRAVRHCRLNSV
  |.... ... ... ..|  . ||| ..  .   .|. |. ...    .||..||||||.|||||..|. .  .   .|  . . . .. || .| ..|
tvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll...lg..vsleealelvrsqrpgav

QMDTQYLMLVEAI
. . |. .| |..
pnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 272-370 1.4e-16 56.0 In-house 40-138 (144) alignment 
Range on Protein: 272-370
Range on HMM: 40-138/144.0
KSGKSHK--LYHYKIITWPDKSIALSNLAILRTLRSLRKM---PGPIVVHCSAGIGRTGTFAAIEvgaQCLLNGkaFRPADLVRAVRHCRLNSVQMDTQY
    . .   ..|  . ||| ..  .   .|..|. ...    .||..||||||.|||||..|.     ....|  . . . .. || .| ..|. . |.
yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay...lmkklg..lsleealalvrsrrpgavpnpgql

LMLV
 .| 
rfLl
subfamily_CG42327_pd Subfamily CG42327 153-304 3.2e-16 53.9 In-house 31-188 (319) alignment 
Range on Protein: 153-304
Range on HMM: 31-188/319.0
KNRYKDVPCNDKTRVILK---DGYPGDYVHANYVKGTK---PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQ--VLTF
|.|. .|    .|||.|.   |     |..|.||.| .     .| .| .|.|.. | ||.| .     |  |..| |.|  .|  |.|  |.     ..
ksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsly

GEITVTCTESTTPDnHTQLKMLTVMDKKSGKSHKLYHYKIiTWPDKSIALSNLAILRTLR
|.| ||  .  . | .  .  | .   .  .| .| ||    |..  .  .. |..  | 
Gdilvtlkgrevkd.ryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamll
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 189-339 4.8e-16 53.5 In-house 5-163 (198) alignment 
Range on Protein: 189-339
Range on HMM: 5-163/198.0
MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTEST-TPDNHTQLKMLTVMDKKSGKSHKLYHYKIITW
 .| || ||..|  |.|.|| . |   | |. .   |       |.| ||  .  .| ..||.   |  ||      .||        . .. ||.. .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDKSIALSNLAI--LRTLRSLR-----KMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLN
 .|.     | .  . . | .      .   |..|||| | | || | |...| .   .
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 189-339 4.9e-16 53.5 In-house 6-164 (199) alignment 
Range on Protein: 189-339
Range on HMM: 6-164/199.0
MFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTEST-TPDNHTQLKMLTVMDKKSGKSHKLYHYKIITW
 .| || ||..|  |.|.|| . |   | |. .   |       |.| ||  .  .| ..||.   |  ||      .||        . .. ||.. .|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDKSIALSNLAI--LRTLRSLR-----KMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLN
 .|.     | .  . . | .      .   |..|||| | | || | |...| .   .
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 150-238 1e-14 49.0 In-house 47-154 (350) alignment 
Range on Protein: 150-238
Range on HMM: 47-154/350.0
EFKKNRYKDVPCNDKTRVILK-----------DGYPGDYVHANYVKGT------KPMF--ILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKC
 | |||||..   ...||.||              . ||. |||.| |      .| |  | ||.||. |  | ....|. .|  | .| ...|... ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

EPYFPDTE
. |... .
yrYWqegs
subfamily_eak_pd Subfamily eak 188-292 2.6e-13 44.1 In-house 93-194 (332) alignment 
Range on Protein: 188-292
Range on HMM: 93-194/332.0
PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDTEGQVLTFGEITVTCTEStTPDNHTQLKMLTVmdKKSGKSHKLYHYKIITW
  .|||  . .|  .  |.|||..   || .| | .|..  | . ||||   ..| || . |.. |     |  . ..| .  .|  ..|...|||.  |
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.vkrniletrllel..skGnethrvlhykvfGw

PDKSI
 . ..
tettl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 143-290 1.2e-12 42.0 In-house 90-233 (244) alignment 
Range on Protein: 143-290
Range on HMM: 90-233/244.0
SIFDKNTEFKKNRYKDVPCnDKTRVILKDGYPG-DYVHANYVK--GTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENgrpkcEPYFPDTEG
  |. |  .|.     .|  |  || |  |  |  |. | .|   |    .|||| || ||.||.|.|.|.  |  . .|  . |.     . |.||.| 
dafnpnnswknregaglpf.dfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdsep

QVLTFGEITVTCTESTTPDNHTQLKmLTVmDKKSGKSH-KLYHYKIITWPDK
      .|||| |.     |    . | . .    .||  |  ..|  ||  
lewyeeditvtltdrdefknikasn.lei.esdmneshqaltmfqisnwpsd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 187-289 4.7e-10 33.4 In-house 235-330 (440) alignment 
Range on Protein: 187-289
Range on HMM: 235-330/440.0
KPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENgrpKCEPYFPDtEGQVLTFGEITVTCTESttpDNHTQLKMLTVMDKKSGKSHKLYHYKIIT
|  || || ||  | .|.||.| .  ...| || .| ..    |  |.|  . . .||| .||    |   .|  ..|. |.  |   . |..  ... |
knafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpv.ntrsvtfgpftvghkgs...enmnrvkvrtlelkykeevheirqfevqt

WPD
|| 
wpt
subfamily_CG42327_pd Subfamily CG42327 307-369 1.5e-09 32.0 In-house 244-307 (319) alignment 
Range on Protein: 307-369
Range on HMM: 244-307/319.0
RKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNG-KAFRPADLVRAVRHCRLNSVQMDTQYLML
|.  ||.||||| |.||||.  | ..  . | .  ..    .||  ||. | ..|.   || ..
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 300-374 5.4e-09 30.3 In-house 218-292 (297) alignment 
Range on Protein: 300-374
Range on HMM: 218-292/297.0
LRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
| .||.    . ...||||||.||.|     .| .. | ...    | ... .|. |   ||   |. .| .|.|
leslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 274-375 1e-08 28.9 In-house 88-192 (440) alignment 
Range on Protein: 274-375
Range on HMM: 88-192/440.0
GKSHKLYHYKiiTWPDKSIALSNLAILRTLRSLRK-----MPGPIVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLM
 .. | |||.   ||||..      .|. .. . .       ||..|||||| ||||   |..   .            .. ..|  | . ||   || .
srtlkqyhyq..gwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

LVEAILD
. ||.|.
vheavle
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 178-290 1.6e-08 28.9 In-house 16-124 (130) alignment 
Range on Protein: 178-290
Range on HMM: 16-124/130.0
VHANYV--KGTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENgrpkcEPYFPDTEGQVLTFGEITVTCTESTTPDNHTQlKMLTVmDKKSGK
..|..|   |    ..||| || ||.||.|.|.|.  |  . .|  . |.     . |.||.|       .|.|| |.    .|    . | . ...  .
inasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknika.snlei.esdlne

SH-KLYHYKIITWPDK
||  |  ..|  ||  
shqaltmfqisnwpsd
0038934 (Phosphotyrosine protein) phosphatases II 269-366 1.6e-08 29.9 In-house 70-165 (194) alignment 
Range on Protein: 269-366
Range on HMM: 70-165/194.0
MDKKSGKSHKLYHYKII-----TWPDKSIALSNLAILRTLRSlRKMPGPIVVHCSAGIGRTGTFAAIevgaqCLLNGKAFRPADLVRAVRHCRLNSVqMD
 |..  ........|..     | |. .| |. | .. .  . .. .| ..||| ||.|||||..|       |.    . . . .. .| .| ... . 
YdpeefekagieylklpfpddgtvPsleillrfldlvdefln.edpggvvaVHCkaGlgRtGtlvaa.....YLiyrlgmsaeeAialfrekRpgai.pn

TQY
 .|
qdy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 313-374 5.8e-08 27.0 In-house 1-62 (69) alignment 
Range on Protein: 313-374
Range on HMM: 1-62/69.0
IVVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAIL
.|||||.| |||||| || |    .   |     . |. .| ||   |  . .|... .|. 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 148-223 9.7e-08 25.9 In-house 35-120 (347) alignment 
Range on Protein: 148-223
Range on HMM: 35-120/347.0
NTEFKKNRYKDVPCNDKTRVILKD--------GYPGDYVHANYVKG--TKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELI
. . .||| |||  .|.|||.|            .  |. | ..|   ..  .|||| || ||  |.|.||    |. .  . | |
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 314-373 1.1e-07 26.1 In-house 1-60 (69) alignment 
Range on Protein: 314-373
Range on HMM: 1-60/69.0
VVHCSAGIGRTGTFAAIEVGAQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVEAI
|||||.| |||||| || |    .   |     . |. .| ||   |  . .|... .|.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 74-237 1.8e-07 24.8 In-house 52-156 (349) alignment 
Range on Protein: 74-237
Range on HMM: 52-156/349.0
NTMHDIFDRDTFAFRLEHCVHPDALNRHSVQTEAfetftttvtsmgvdglakeyletlvpflpvgyfersifdkntefkknrykdvpcndktrvilkDGY
|  .||.  .    .|.. ... .  ..|  .                                                                  | 
nrykdilPyehsrvklkkslksskvikastsesd...............................................................sgk

PGDYVHANYVKGTK----PMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCELIENGRPKCEPYFPDT
. ||. |||.| |.      .| || ||  |  | ....| .||  .  | .  |..  ||. |. . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 310-332 7.7e-07 23.1 In-house 262-284 (350) alignment 
Range on Protein: 310-332
Range on HMM: 262-284/350.0
PGPIVVHCSAGIGRTGTFAAIEV
  ||.||||||.|||||. ... 
sspilvhCsaGvGrtGtlvtlDs
subfamily_CDC14_pd Subfamily CDC14 299-365 8.6e-07 23.1 In-house 252-313 (328) alignment 
Range on Protein: 299-365
Range on HMM: 252-313/328.0
ILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAIevgaqCLLNGKAFRPADLVRAVRHCRLNSVQMDTQ
. . |. . |. | |.||| ||.|||||. |       |..   |  |. .  .| ||  ||    |
vkkfleiaekaeGaiavhCkaGLGrtGtLiac.....ylmkhyrftaaeaiawlricrPGsvigpqq
PTEN_1 304-356 1.1e-06 23.6 In-house 121-171 (196) alignment 
Range on Protein: 304-356
Range on HMM: 121-171/196.0
RSLRK---MPGPIVVHCSAGIGRTGTFAAievgaQCLLNGKAFRPADLVRAVRHCR
 . ..     . ..||| ||.||.|| .|      .|.  . . . . .. || .|
iewllsdpngnvVlVHCkaGlgRsGtvva.....ayLmykgkltadeAlelvrekR
subfamily_PTPDC1_pd Subfamily PTPDC1 310-371 1.5e-06 22.8 In-house 114-170 (182) alignment 
Range on Protein: 310-371
Range on HMM: 114-170/182.0
PGPIVVHCSAGIGRTGTFAAievgaQCLLNGKAFRPADLVRAVRHCRLNSVQMDTQYLMLVE
 | . ||| || ||||   |       |.  | . ... .. ||. | .|.|  .|  ...|
egkvavhChaGlGrtGvlia.....cylvyakrltaekaiklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 155-239 2.3e-06 19.4 In-house 50-135 (327) alignment 
Range on Protein: 155-239
Range on HMM: 50-135/327.0
RYKDVPCNDKTRVILkdGYPGDYVHANYVKGTKPMFILTQGPLKDTAMDIWRMVLQEGVAAICMLCE---LIENGRPKCEPYFPDTEG
    .|  |. ||.   |   ...  .||.     .|. | | | ..  |||..|.. .  .  ||    .      ||  |||    
vrlpipirdnrrvlc..gsdeeffpgqyvrmegaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfptele
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 276-332 7.5e-06 19.5 In-house 217-287 (349) alignment 
Range on Protein: 276-332
Range on HMM: 217-287/349.0
SHKLYHYKIITWPDKSIALSNLAILRTLRSLR--------------KMPGPIVVHCSAGIGRTGTFAAIEV
 ..|.  ..  |.| |. |   .||..|                  .   ...|||||| ||||..  ...
PyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldl
Y_phosphatase3 Tyrosine phosphatase family 296-330 8.3e-06 20.9 Pfam-A 110-144 (164) alignment 
Range on Protein: 296-330
Range on HMM: 110-144/164.0
NLAILRTLRSLRKMPGPIVVHCSAGIGRTGTFAAI
. |. . |. |.. .||...||.||  ||| .||.
kkayrkvlealaeeegpvlfHCtaGKDRTGvvaal
0048567 (Phosphotyrosine protein) phosphatases II 298-366 9.2e-06 20.1 In-house 62-128 (157) alignment 
Range on Protein: 298-366
Range on HMM: 62-128/157.0
AILRTLRSLRKMPGPIVVHCSAGI---GRTGTFAAIevgaqCLLNGKAFRPADLVRAVRHCRLNSVQMDTQY
 . . |..|.. ...|.|||.||    |||.|...       |.    | |.. .. .| .| .||    ..
klnkflkilelagkaiavhckaglkkrgrtatLigc.....Ylilhlgftpeeaiaplrivrpgsvpfrdas