Gene F36H12.10 in Caenorhabditis elegans

Synonym: CELE_F36H12.10, CELE_F36H12.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf10
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP078_AA protein Get Run
CeleP078_AA_84-366 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 77-381 1.3e-214 705.3 In-house 1-305 (305) alignment 
Range on Protein: 77-381
Range on HMM: 1-305/305.0
TPAPPQTHPIVEQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMIPEKRFIC
|||||||||||||.||||||||||||||||||||||||||||||.||||||.||||||||||||||||.||||||.|||..|||||||||||||||||||
tpappqthpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrfic

AQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPD
||||||||||||||||||||||||||||||||.|||||||||||||||||.||||.||||||||||||||.|||||.|||||||.|.|||||||||||||
aqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpd

RGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAAL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
rgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaal

LTAEN
|||||
ltaen
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 86-393 6.9e-109 358.6 In-house 2-306 (307) alignment 
Range on Protein: 86-393
Range on HMM: 2-306/307.0
IVEQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPS-PCNYIHANYVGCPMIPeKRFICAQGPLDQT
.|. || |.|| ||..|..||| |||.|   .|   |.||.       |||||||.||| . . .  .    .||||||.|  . | |.||||||||..|
vvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantd......knryqdvkcqdkgrivvkfdglasdyihanylgiaikp.kkficaqgplent

IDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC---VVENVsGSKPMERDP-EIQITMLNLTYSGgQTMSVRHLQWTEWPDRGVP
. .|| |.||.||| ..||||..|..|.|| ||||. .|.||.  .      |.|. |.| .  |   |..| |.. ... .. ...||||..|||||||
qysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanl.gakklapdedlinvttlkvdwaq.ksrtiqhlqwenwpdrgvp

PCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAAL-LTA
. .||...||.|.|. . |.|||||||.||.|||||| .. .|. . . |  | .||. ||.|| ..||...|||..|||.|.||||.||| |. | || 
qinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltk

ENVAKYDKFIKDYN
.   || |.. |||
nyeekyakwlddyn
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 88-368 1.7e-78 258.4 In-house 10-290 (305) alignment 
Range on Protein: 88-368
Range on HMM: 10-290/305.0
EQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaiTKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDE
 ..| |.|. |   ||.|| .. ..   .  . . .|...      ||||.|| | |   |||. | | .|||||||  |  | |||||.| ||..|  .
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqea.....gknrykdvgcldnnrvklegpwpheyihanyvstptnp.krfictqaplektcad

FWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC----VVENVSGSKPMERDPE--IQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPP
||.| .|.|||.| |||. .| |  ||..|... ....|... .     |  . |..  ...| .  .. |.| .  .|...  | |  | .|||||||.
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpa

CKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
  |. ||||   | || ||||||||||||||..| .||||... . .       ... .|.||  ||| | ||||.|.|.||||..|
adlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
0040438 (Phosphotyrosine protein) phosphatases II 89-373 6.1e-78 257.6 In-house 7-284 (317) alignment 
Range on Protein: 89-373
Range on HMM: 7-284/317.0
QWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKrFICAQGPLDQTI
...|. |  .. .|.|||. | ... ....  .. .|..      |||| |... | | |||  ...   ..||.|.|| .| .. | ||..||||..|.
lalldllksdftalleefedllslkldtysvaelpenkd......knrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPlpntv

DEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTLkSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKL
. ||.|| ...|. ||||....|.|. |||||||   ||.||   . .|...|  .    ...|... | ...  ....  |.|...| ||| ||||   
edFwrmvweqgvtvivmLteleelgrekcaqYwpl..getlty.gdftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

TSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKY
. |..|.|.| .    . |..||||||.|||||..|....|| . ... .. ..| || || ||. ..|.  || |.....|.|.. |.. ..
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep
0050432 (Phosphotyrosine protein) phosphatases II 131-369 5.6e-77 254.4 In-house 68-303 (308) alignment 
Range on Protein: 131-369
Range on HMM: 68-303/308.0
AITKNRYQDVPCQDLSAVKLdqPSPCNYIHANYVGCPM-IPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLK
 ..|||| |... | | |||  .....||.|.|| ... . ...||..||||..|.. ||.|| ...|. ||||.|.||.|. |||||||  .|.. .  
nkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsley

SGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS--KVPIVVHCSAGIGRTGTIVAIEYILEKIAE
 . .|...|  .    .... .. | ||. ..|..  |.|...| ||| ||||     |..| ..| |  . |||||||||.|||||..|....|| . .
gkftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlek

NkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
.  .. ..|.|| || ||....|.  ||||..|..| |.. |.
e.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
DSPc_SM00195 101-365 4.6e-76 251.0 In-house 1-262 (263) alignment 
Range on Protein: 101-365
Range on HMM: 1-262/263.0
KLREEFRGLAKYTRP-DMTQVMFNANQspdiaiTKNRYQDVPCQDLSAVKLDQP---SPCNYIHANYVGCPmIPEKRFICAQGPLDQTIDEFWWMVIQNK
||.|||. | ..| | ..|.. ...|.      .||||..... | . |||...   .. .||.|||. ..  ..|..|..||||..|...||.||...|
klkeefekleestspketteaekkknk......sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweek

VEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKsGCVVENVSGSKPMerdPEIQITMLNLTYSGG-QTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG
|..||||.. .| || ||..|||  .|.| | .    |..|.  |      ||... |.||. |  .| .|...|...|||.|||  .   ||||.|.. 
vkiivmlteeeengkekcdrywpeesggketfg.kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

S----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
|    ..|||||||||.|||||.|.|..||.|..|.|  . . |.||.||.||. ..|.. |||||....|.|.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 101-365 4.6e-76 251.0 In-house 1-262 (263) alignment 
Range on Protein: 101-365
Range on HMM: 1-262/263.0
KLREEFRGLAKYTRP-DMTQVMFNANQspdiaiTKNRYQDVPCQDLSAVKLDQP---SPCNYIHANYVGCPmIPEKRFICAQGPLDQTIDEFWWMVIQNK
||.|||. | ..| | ..|.. ...|.      .||||..... | . |||...   .. .||.|||. ..  ..|..|..||||..|...||.||...|
klkeefekleestspketteaekkknk......sknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweek

VEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKsGCVVENVSGSKPMerdPEIQITMLNLTYSGG-QTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG
|..||||.. .| || ||..|||  .|.| | .    |..|.  |      ||... |.||. |  .| .|...|...|||.|||  .   ||||.|.. 
vkiivmlteeeengkekcdrywpeesggketfg.kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkk

S----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
|    ..|||||||||.|||||.|.|..||.|..|.|  . . |.||.||.||. ..|.. |||||....|.|.
skstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0036941 (Phosphotyrosine protein) phosphatases II 132-368 2.7e-74 245.5 In-house 40-280 (297) alignment 
Range on Protein: 132-368
Range on HMM: 40-280/297.0
ITKNRYQDVPCQDLSAVKLdQPSPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLkSG
..|||| |... | . ||| ......||.|.|| .. .. | ||..||||..|...||.|| ...|. ||||.. ||.|. |||||||  .|| ||   .
leknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegeslty.gd

CVVENVSGSKPmeRDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYILEKI
 .|...| ..    .... .. | .|.  .|..  |.|...| ||| |||..  . |... ..|       |. |..||||||.||.||..|....|. .
ftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqql

AE--NKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
 .    ......|.|| ||.||....|.  ||.|.....|.... |
edklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0046845 (Phosphotyrosine protein) phosphatases II 102-369 7.1e-74 244.0 In-house 2-278 (284) alignment 
Range on Protein: 102-369
Range on HMM: 2-278/284.0
LREEFRGLAKYTRPD---MTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPM----IPEKRFICAQGPLDQTIDEFWW
|.|||. | ..| .    ..  .. .|      ..||||.|... | | |||. ...    ..||.|.|| ..     . .|.||..||||..|...||.
leeefeellsltvklllslsvallpen......lsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwr

MVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqGEKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTYS--GGQTMSVRHLQWTEWPDRGVPPCKLTSLE
|| ...|. ||||...||.|. |||||||   ||.||..    |...|  .    .. . ...| ||.   .|... |.|...|.|||.||||     ||
mvweqnvrvIVmltelvengrekcaqYwple.gevltygd.ftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlle

LLSAIRGS------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKP--CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
.| ..| .      . |||||||||.|||||..|....|| . ....  .....|.|| ||.|| ...|.  ||.|.....|.|.. |.
flrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 81-369 2.1e-73 242.7 In-house 13-293 (297) alignment 
Range on Protein: 81-369
Range on HMM: 13-293/297.0
PQTHPIVEQWVLRALDVGVDKLREEFRGLAKYTRPdMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPMIPEKRFIC
| .  ......|.    .  .|..||  | ... . ..  .. .|..      ||||.|... | | |||  .      ..||.|.|| .. .  ..||.
piplsvldlllllekansktllllefeellslkpd.ysiallpenkd......knrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIa

AQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGekltLKSGCVVENVSGSKpmerDPEIQITMLNLTYsGGQTMSVRHLQWTEWPD
.||||..|.. ||.|| ...|. ||||.|.||.|. |||||||  .|       . .|....  .    .. . .. |..|. .|..  |.|.|.| |||
tqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg....tygdftvtllkveh....ldgytvrtlevtn.ngesrtvthfqytgwpd

RGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
 ||||.  . ||.| ..|       .. |..||||||.|||||..|. ..|| . | . .. ..| || || ||  ..|.. || |.....| ... |.
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql.ekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 76-367 8.2e-73 241.1 In-house 3-306 (307) alignment 
Range on Protein: 76-367
Range on HMM: 3-306/307.0
MTPAPPQTHPIVEQWVLRALDVGVDKLREEFRGLAKYTRPD---MTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPM
. . ..  . . ...||. |  .. .|..||. | ..| ..   ..  .. .|      ..||||.|... | . |||  ...    ..||.|.|| .|.
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpen......kdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpl

I-------PEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqGEKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTY--S
.         ..||..||||..|...||.|. ...|. ||||...||.|. |||||||   ||.|| .   .|...| ..    ....... |..|.   
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn.ftvtllseeh....ldgytvrtlevtdldg

GGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPC--PPMPELVKALRDQRAFSIQND
 |..  |.|...|.||| ||||   . |... ..|       .. |..||||||.|||||..|. ..|. . ... .  ....| || ||.||  ..|| 
tgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnp

VQYLFIHRVMLNYFLE
 || |.....| ..|.
eqyrflyeallelllk
0047943 (Phosphotyrosine protein) phosphatases II 101-365 1.2e-72 239.9 In-house 13-272 (273) alignment 
Range on Protein: 101-365
Range on HMM: 13-272/273.0
KLREEFRGLAKYTRPDMTQVMFNANqspdiAITKNRYQDVPCQDLSAVKLdQPSPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQI
.|.|||. | ... .  ..|    .      ..||||.|... | | ||| ......||.|.|| .. .. | ||..||||..|...||.|| ...|. |
llleefelllslkplltysvallpe.....nkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmvweqnvrvi

VMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG----
|||...||.|. |||||||  .||  .      |...|  .    .. . .. | ||. . |..  |.|...|.||| ||||     ||.. ..|     
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
  |. |.|||||||.|||||..|....|. . ..  .. ..|.|| ||.||  ..|.  ||.|.....|.|.
lpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 96-365 1.5e-72 239.8 In-house 19-286 (288) alignment 
Range on Protein: 96-365
Range on HMM: 19-286/288.0
DVGVDKLREEFRGLAKYTRPdmtqvMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMV
  |. .|.|||. | ... .     .     .    ..||||.|... | | |||  ...   ..||.|.|. .. .. | ||..||||..|...||.||
angltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmv

IQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTY-----SGGQTMSVRHLQWTEWPDRGVPPCKLTSL
 ...|. ||||.|.||.|. |||||||   |..||..   .|...|  .    .... .. | .|.      .|..  |.|...| ||| |||.     |
weqnvrvIvmltklvelgrekcaqYwpl..ggsltygd.itvtllseev....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

ELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
..| ..| .    . |.|||||||.|||||..|....|| . ..  .. ..|.|| || || ...|.  ||.|.....| |.
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
Y_phosphatase Protein-tyrosine phosphatase 133-363 1.4e-71 236.0 Pfam-A 3-235 (235) alignment 
Range on Protein: 133-363
Range on HMM: 3-235/235.0
TKNRYQDVPCQDLSAVKL-DQPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSg
.||||.|... | . ||| ....|..||.||||      .|.||..||||..||..||.||.|.||. ||||.. .|.|. ||||||| ...|.|| .. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd.

CVVENVsgSKPMERDPEIQITMLNLTYSGGQT--MSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKIA
  ||..  .|  | . |.... |.|. .....   .|..|..|.|||.||| ..   |.|. ... ||     |.|||||||.|||||.||....||.. 
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

ENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
...  . . ..|| || ||. ..|.  || |.....|.
aeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 133-363 1.4e-71 236.0 In-house 3-235 (235) alignment 
Range on Protein: 133-363
Range on HMM: 3-235/235.0
TKNRYQDVPCQDLSAVKL-DQPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSg
.||||.|... | . ||| ....|..||.||||      .|.||..||||..||..||.||.|.||. ||||.. .|.|. ||||||| ...|.|| .. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd.

CVVENVsgSKPMERDPEIQITMLNLTYSGGQT--MSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKIA
  ||..  .|  | . |.... |.|. .....   .|..|..|.|||.||| ..   |.|. ... ||     |.|||||||.|||||.||....||.. 
ikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

ENKPcPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
...  . . ..|| || ||. ..|.  || |.....|.
aeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0043336 (Phosphotyrosine protein) phosphatases II 92-365 7.9e-69 227.5 In-house 12-277 (278) alignment 
Range on Protein: 92-365
Range on HMM: 12-277/278.0
LRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaitKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEF
|. |  .  .|..||  | ... ....  .. .|..      |||| |... | | |||.  .   ...||.|.|| .. .|.| ||..||||..|.. |
lelllnlktllllefeellsfkldtysiallpenkd......knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgPlpetvedF

WWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPaaqGEKLTLkSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSL
|.|| ...|. ||||.. ||.|. |||||||   |. ||   . .|....  .    .. . .. |..|.   |..  |.|.... ||| |||.   . |
wrmvwelgvttivmLtelvelgrvkcaqYwp...ggslty.gdftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

ELLSAIRG----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
..| |.|     |. |..||||||.|||||..|....|| .  .. .....| || || ||. ..|.. || |.....| |.
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
0045098 (Phosphotyrosine protein) phosphatases II 133-367 6.1e-66 217.9 In-house 35-274 (278) alignment 
Range on Protein: 133-367
Range on HMM: 35-274/278.0
TKNRYQDVPCQDLSAVKldqpspcNYIHANYVGCPmiPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqgEKLTLKSGC
 |||| |... | | ||       .||.|.|. ..  | |.||..||||..|.. || |. ..... ||||.. ||.|. |||||||    ..     . 
dknRykdilpydhsrVk.......dYINAsyidgy..p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...ggsltygdf

VVENVSGSKPmerdPEIQITMLNLTY-----SGGQTMSVRHLQWTEWPDRGVPPCK--LTSLELLSAIRG-----------------SKVPIVVHCSAGI
.|...| .      ... ...|..|.     ...... |.||... ||| |||.       ||||  ||                  |. |..||||||.
tvtllseevl....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

GRTGTIVAIEYILEKIaenKPCPPMPELVKALRDQRAF-SIQNDVQYLFIHRVMLNYFLE
|||||.||. ..|| .   ..   ..| || || || . ..||  || |.....| ..| 
gRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 132-367 1.7e-65 216.4 In-house 12-248 (249) alignment 
Range on Protein: 132-367
Range on HMM: 12-248/249.0
ITKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTL
. ||||.|... | | |||       ...||.|.|. .. |. . ||..||||..|.. ||.|. ..... ||||...||.|. |||||||   |. |. 
kdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsley

kSGCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG------SKVPIVVHCSAGIGRTGTIVAIEYIL
  . .|...|  .     ... ...| ||.   |..  |.|.|.| ||| ||||   . |... |.|       .. |..||||||.|||||..|. ..|
.gdftvtllsvev....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

EKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
| . ..  . ...| || ||.||  ..||. || |.....| ..|.
eqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 132-365 1.7e-64 212.9 In-house 10-243 (245) alignment 
Range on Protein: 132-365
Range on HMM: 10-243/245.0
ITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqGEKLTL
..|||| |... | . |||  ...   ..||.|.||... |..| ||..||||..|.. ||.|. ..... ||||....|.|. |||||||   ||.|| 
kdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslty

KSgCVVENVSGSKpmerDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG-----SKVPIVVHCSAGIGRTGTIVAIEYILE
.   .|...|  .    .... .. |..|.   ...  |.|.... ||| |||.   . |..|...|      |. |..||||||.|||||..|. ..||
gd.ftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

KIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 . ..  . ...| || ||.||  ..|.. || |.....|...
qleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 93-365 5e-63 207.4 In-house 20-283 (290) alignment 
Range on Protein: 93-365
Range on HMM: 20-283/290.0
RALDVGVDKLREEFR-GLAKY-TRPDMTQVMFNANQSpdiaITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPmipEKRFICAQGPLDQTIDEFWW
 . . .||.|  |.   |  |     . . .|..|      ..||||.||.|.| . | |..  . .|.|||||      .  || .||.| .|. ..| 
dvvkknvdelakeyleklkpylpvqylerkifdknte....fkknrykdvvcndktrvilkdGydGdyvhanyvkGl...kamfiltqGalkdtvidiwr

MVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVenvsGSKPMERDPEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLEL
||.|.||  |||||. .| || ||.||.|  .|| ||. .  |.     |.  ..| .|.  .| .     |.   ..||.   |||. |.  .|. | .
mvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvl....cseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrt

LSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| ..|    |.|||||||||||||.||||  |. . . |   .. .||.|||. |. |.| |.||| . ...|.. 
lrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldll.dlvralrnsrlnsvqvdiqylalveilldlG
0037934 (Phosphotyrosine protein) phosphatases II 132-365 1.4e-61 203.5 In-house 11-242 (243) alignment 
Range on Protein: 132-365
Range on HMM: 11-242/243.0
ITKNRYQDVPCQDLSAVKLdqpSPCNYIHANYVGCPmipeKRFICAQGPLDQTIDE----FWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPaaqGEKlt
..||||.|... | | |||   ....||.||.. ..    .|.|. ||||..|...    || |. ..... ||||...||.|..|||||||   ||.  
lsknrysdilpydhsrvkl...egsdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev..

LKSGCVVENVSGSKpmerDPEIQITMLNLTY--SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR------------GSKVPIVVHCSAGIGRTGT
   . .|...| .      ... ...| |..   ...|  |.|.... ||| |||.     |..|...|             |. |..||||||.|||||
tygdftvtllseeh....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

IVAIEYILEKIaenkpCPPMPELVKALRDQRAF-SIQNDVQYLFIHRVMLNYF
..|. ..|...     . .. | || ||.|| . ..|.  || |.....| ..
liaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRD_pd Subfamily PTPRD 102-365 5.6e-59 195.2 In-house 25-281 (564) alignment 
Range on Protein: 102-365
Range on HMM: 25-281/564.0
LREEFRGLAKYTRPDMTQVMFNANQspdiaiTKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVE
. ||.. . . ..  ...   .||.       ||||...   | | |.|    . . ..|| |...   .  .| .| .|||| .||..|| || .....
feeeykkieegqqftweaankpaNk......aKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnss

QIVMLCKTVEMGKLKCAQYWPAAQgeklTLKSGCVVENVSGSKPMErdpEIQITMLNL-TYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-
 |||| |..|.|| ||..|||. .    | . | .. ... .. ..   ...|. ..| . .  ... ||. ..|.|||.|||    . |.|.. .| . 
tiVmltkleEkgkvkchkYWPekg....tetygeltVtleeeeela...dyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln

---KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
   . |||||||||.||||| ..|...||.| |.|    . . ||||| || . .|.  || |||...|.. 
epdagPivVhCSaGVGRTGtfividamlerikeektv.DiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 86-370 5.2e-58 191.3 In-house 5-277 (288) alignment 
Range on Protein: 86-370
Range on HMM: 5-277/288.0
IVEQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNaNqsPdiaiTKNRYQDVPCQDLSAVKLDqPSPCNYIHANYVGCPMIpEKRFICAQGPLDQTI
..  |. . |...|. |  |.|   . .  |. ..  . |  |    |..||...|. |.. |||.   |  ||.|| | .    ..|.|||| ||. ||
vinawirlvlqiaveglkkeyrdspneasidiidsfia.n..p....trdryenlprcditrvkls.ddpdfyiaanvvssaky.krrlicaqaPlngti

DEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGskpMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLT
.|.| |.... || |||||. .| || | |.|.|  .|||  ..  | |  ..     . |  .....|. .  | ... |..| . ||.| |||   |.
eelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenyls

SLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK-YK
 | ||  ..  . |||||.|||.|||||.. |  .|| .  .     ...|.. ||..|  .||   |||..||..|...| | ||
plrllevlkslqkPivvhssaGvGrtgtlililialeslrldd.flgirsllaklreerfkaiqtemqylyvhrcvleelllkkyk
subfamily_PTPN12_pd Subfamily PTPN12 100-370 1e-57 190.3 In-house 8-282 (290) alignment 
Range on Protein: 100-370
Range on HMM: 8-282/290.0
DKLREEFRGLAKYTRPDMTQVMFNANQ-SPDIAITKNRYQDVPCQDLSAVKLDQPSPCN---YIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQN
... .||  | | ..   .. ...... . .  ..||||.|.   | | |.| . .  .   || ||..  .   ....| ||||| .|.|.|| |... 
eefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiwek

KVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVveNVSGSKPMERDpeIQITMLNLTYSgGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG
.|| .||.|. ||.|| ||..|||  ..|.|.  . .|  ...  | .. |  . | .|... . ... .|. ...|.|||.|||  . . |||....| 
nveivvmaCrevelgkkkCerYWpeegeeelefgefev..tleeekavddd..flirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvre

----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKP--CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYK
    ...|.|||||||.||||||.||.|. | . ..|   .  . .||  || |||  .|   || .... ..... .. .
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_PTPRB_pd Subfamily PTPRB 121-370 1.8e-57 189.6 In-house 43-290 (293) alignment 
Range on Protein: 121-370
Range on HMM: 43-290/293.0
MFNANQSpdIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMIpEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQY
.  |...  .  .||||...   | | |||   .. |  .|| |||.      .. || .|||| .|.|.|| || ..|.. |||| ..|| || || .|
vkaaela..vnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeY

WPAAQGEKltlKSGCVVENVSGSKPMErdpEIQITMLNLTYsGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK------VPIVVHCSAGIGRT
||| . .      | .  ..  .. .|   .  |  |...  . ....||....| ||| |||    | |... ..| ..       |||||||||.|||
WPadeepv...lyGdikvtlvaeeele...dwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRt

GTIVAIEYILEKIAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYK
|| .|.. .|..| |.     .  .| .|| .|.. .|.  ||.|||...|... .| .
Gtfialdrllqaieeedyvdif.givaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 129-366 1.1e-56 187.0 In-house 39-277 (281) alignment 
Range on Protein: 129-366
Range on HMM: 39-277/281.0
DIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGek
|  ..||||...   | . ||.   .. . ..|| ||.|   .  ||..| .|||. .....||.||...||..|||. . .| ||||| .|||  .   
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpg.ykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns..

lTLKSGCVVenVSGsKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI-----RGSKVPIVVHCSAGIGRTGTIVAIEYI
 .|| | |.  |.  .  |. ..     ..|. ..|.| .|..|..| ||| |||      ||  ...     . .|.|.|.|||||.||||| .|.. .
.elkygdvt..vks.taeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl

LEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
.........   . ..|. || .| . .|  ||| |.....|... 
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 130-368 5.7e-55 181.4 In-house 41-293 (297) alignment 
Range on Protein: 130-368
Range on HMM: 41-293/297.0
IAITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
  ..||||.|| | | . |.|    . .  .||.||.|      .| || .||||..|...|| || ...|  |||  ..||.|.|||.||||  ...  
anleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessa

TLkSGCVVENVSGSKpMErdpEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-----------------KVPIVVHCSAGI
   .   |.||.  . .|   . ....|...    ... .| | | . ||| |||    . |..|...|                   . ||||||||||
ef.gdlsvsnvevee.ee...dykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
||||| ..... |... |   .  . | || || ||||||| . || | .  .|.| ||.
GrtGtfitldiclsrleevgtv.dvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN3_pd Subfamily PTPN3 131-365 1.1e-54 180.3 In-house 41-275 (280) alignment 
Range on Protein: 131-365
Range on HMM: 41-275/280.0
AITKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVGCPMIP---EKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaQGEKLT
 ..||||.|.   |   |||.. .  .|| ||||   .      .|.| .||||..|  .|| || ..|.. ||||  .|| |. || ||||  ....|.
nlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedele

LKsGCVVENVSGskpMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG----SKVPIVVHCSAGIGRTGTIVAIEYILEK
.  .  |.  .     |.   .   ..    .  .  .. .||...||| |||  .   ||... .|     .. |.|||||||||||| ....|  | .
yg.efsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalal

IAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| ...|  |. ..|. .|||||  .|.  || |.   .|. .
ieaaepvypl.divrtmrdqramlvqtasqykfvCeailkvy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 79-365 1.1e-53 177.2 In-house 2-279 (288) alignment 
Range on Protein: 79-365
Range on HMM: 2-279/288.0
APPQTHPIveQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANQSpdiaiTKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCpMIPEKRFI
.|....|.  ..| ..   . . . ||.. ||.  . . ...  .|.       .||||...   |  .|||..    .  .|| |.|.      .|..|
epihispv..akvakksarnrtgfseeynsLaalektksvtagrlavna.....kknRyrnilpyDekrvklkkleeeagaDYinasyidg.ekkkkkyi

CAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKltlKSGCVVENVSGSKPMERdpEIQITMLNLtySGGQTMSVRHLQWTEWP
..|||| .|...|| .| .||.. |||| . || || || .|||.|. .|   . | |   . .|| .|    .. ..|      .. . . ..|.. ||
atqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpk...nyGsvtvtlveskeled..fvlrkllle..kkkteleitqyqylaWp

DRGVPPCKLTSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| |||  |   ||||. .  .      ||.||||||.||||| .|.. ..... |..    . . |. || |||. .|.  || ||..|.|.  
dhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiD.vagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN13_pd Subfamily PTPN13 131-363 3.5e-53 175.6 In-house 37-267 (273) alignment 
Range on Protein: 131-363
Range on HMM: 37-267/273.0
AITKNRYQDVPCQDLSAVKLDQPSPcnYIHANYVGCPMIPEK-RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLK
  .||||..|   | . |||.. ..  || |...  |.  .. ..| .|||| .|...|| || . |.| |.|. . .| ||.|| .|||  ...||...
nkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvs

SGCVVENVSGSKpmeRDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR---GSKVPIVVHCSAGIGRTGTIVAIEYILEKIAE
.   ||..   |   .|   . ..       |..  | ||....||| |||   .  |.... .|    .. ||||||||||||.||...|. .|. |. 
nrlevellkvqk...ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglier

NKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
.|.  .. |.|. ||.||   .| . ||.|.....|.
dkef.dvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 99-365 1.8e-51 170.2 In-house 26-290 (298) alignment 
Range on Protein: 99-365
Range on HMM: 26-290/298.0
VDKLREEFRGLAKYTRpDMTQVMFNANQSPDiAITKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQN
. .. .||. | . .  .. .   .. ..|.    ||||.|.   | | | | .      ..|| | ..      .. || .|.|| .|. .|| ||...
ltgyalefqrlnsvss.eieeeekevarkpe.nkkkNRyadiialdssRvvLekedadeesdYiNAsflhayk.grnafiatqaPltetvedFWrmvtee

KVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLtlkSGCVVenvsGSKPMERDPEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR
... |||| ...|..|.|. .|||  . |.        |      .  |.  .. .. |... ..  .. .||.|..|.|||.|||  . . |.||. .|
digtiVmltnleeldktkyhkywPdegkety...geitv....sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

GS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 |     ..|..|.||||.||.|| .||. .||.. ...    . . ||.|| .|. ..|   || ||. ..|...
asqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 128-365 2e-51 169.6 In-house 15-264 (270) alignment 
Range on Protein: 128-365
Range on HMM: 15-264/270.0
PDIAIT--KNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQ
|..| .   |||.|.  .  . |.|   .. |  .|| ||||      .|..|.|.|||. |. .|| |....||. |||. . .| |. ||..|||| .
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

GEKLTLKSGCVVENVSGSkpmERDPEIQITMLNLTySGGQTMSVRHLQWTEWPDRGVPPCKL------TSLELLSAIRGSK------VPIVVHCSAGIGR
.||..|. | .   .. .   |..    .| |.|. . |..  . | ....|||.|||. .         |..| |.| |.       |..||||||.||
kekvkledgkikvlalse...ekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgR

TGTIVAIEYILEKIAENKPCPPMpELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
|||..|...... . |.| . .. .....|| .|   .|  .|| |.......| 
tGtlialDiavrlLeetkkvdvl.aiieelRkdRmalvqhpeqyeflykavveya
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 97-364 8.5e-50 164.6 In-house 20-282 (319) alignment 
Range on Protein: 97-364
Range on HMM: 20-282/319.0
VGVDKLREEFRGLAKYTRPdmtqvMFNANQSPdIAITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVI
 |  .|..||. | . .        |.  . . .  .|||||..   | . |.|    .    .|| |...      ...|| .|.||..||..|| || 
tgetllekefkllkeavnd.....tfdsaske.enkkknryqnilaydrtrvvlseldgvegsdyinasfidg.yqerekfiatqaPlentiedfWrmvW

QNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKltlkSGCVVENVSGSKpMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI
....  .|||.| || .|.|. .||| .. |.     | .. ..   .    | .|.  .||   |  .| .| | |.||||| .||   .. |.||  |
eeessivvmltklveklkvklkkywpeenfee....yGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkri

RGSK-----VPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
| |.      |||||||||.||||| .... .||.. |.     . . |. || || . .|.  || ||. ..|..
rksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvl.DvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 130-365 2.4e-49 163.1 In-house 45-283 (305) alignment 
Range on Protein: 130-365
Range on HMM: 45-283/305.0
IAITKNRYQDVPCQDLSAVKLDQPSPC---NYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
   .|||....  .| . ..| . .     .|| |.||      .|..| |||||..|...|| .... ||..||||.|.|| || || |||| ...|| 
ankaknrlkeitlldddriiltekeslddsdyinasyvdg.ykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekk

TLKSGCVVenVSGSkpmERDPEIQITMLNLTY--SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR-----GSKVPIVVHCSAGIGRTGTIVAIEY
 . .  |   .. .   .  ..  .  |...   .  .. .| ..| |.||| |||    . |.|.  ..     . .||..||||||.||||. .|.. 
efgefsve..lkse...ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdi

ILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 ||.. . .    . |..|.|| .|   .|.  || |.| .. .. 
alerlkkEevv.dvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_PTPN6_pd Subfamily PTPN6 102-367 4e-49 162.3 In-house 28-299 (306) alignment 
Range on Protein: 102-367
Range on HMM: 28-299/306.0
LREEFRGLAKYTrpdMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPC--NYIHANYVG-CPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVE
. |||  | .     .....   . .     .||||. .   | . |.| .||    .|| |||.       .|..| .|| |..|. .|| || |.. .
feeefeelqqee...akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensr

QIVMLCKTVEMGKLKCAQYWPAAQGEKLtlKSGCVVENVSGSKpMeRDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS--
 |||. | || || |||.|||... ..        |.||| .. . .| ..   ... . ..... .|.......||| |||  . . |..|. ..    
vivmttkevErgkekCarYWPdeeekee..yGkisvtnvseks.l.adYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCP--PMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
      . |||||||||||||||.. |. .|..| ...      . .||| .|.||   .| . || |..... .|  .
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 131-365 4.1e-49 162.1 In-house 28-268 (274) alignment 
Range on Protein: 131-365
Range on HMM: 28-268/274.0
AITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
. |||||...   . | | | . |.     .|| |||.  .   .| .. .|||| .|...|| |. |..|. |||| |  |. . |||.|.| |.. ..
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

TLKSGCVVenVSGSKpMERDPEIQITMLNLTYSGGqTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK-------VPIVVHCSAGIGRTGTIVAIEY
. . | |   .  .| . .  . ... | | |.   . || |  .|.|||. .|    | |.|.  .. |.        |.||||||||||||  .||. 
serygdve..ikvek.iverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi

ILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 . .. |..    . ..|  || .|   .|.. || .|||..  | 
avrqlreeivvd.vlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 88-380 4.2e-49 161.8 In-house 15-305 (310) alignment 
Range on Protein: 88-380
Range on HMM: 15-305/310.0
EQWVLRALDVGVDKLREEFRGLAKYTRPDMTQVMFNANqspdiaITKNRYQDVPCQDLSAVKL--DQPSPCNYIHANYVGCPMIpEKRFICAQGPLDQTI
|.... .  .|.. |  ..| |     . .|   .. .      . |||| || |.| | |||  |.    .|||||||    .  . |||.||||..||
enfiiateklgieglvkqyrkldakqdssltyeaykky......mhknrysdvvcldtsrvklkidksryedyihanyvktnyl.rstficsqgplqhti

DEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqGekLTLKSGCV-VENVSGSKPMERDPEIQITMLNLT------YSGGQTMSVRHLQWTEWPDRG
 .|| |..|.. | |..|||..| |. ||  |||.  |  .|   ||. | |.| |       .. .|..          .  . . |  ..| .|||||
idfwrmifqeraesilllckvgeegrpkcvgywpsl.g..vtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrg

VPP--CKLTSLELLSAIRgsKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAAL
||   |.     ||. .|  . | |||||||..|....||... ..|. . .    . |..  |. .||  ||...|||.|.||.. .   . .    .|
vpdekchtvpqrllaqvr..hgpcvvhcsagkdrlyvvvalklkidkldrglkv.daeevktellksraiciqtelqyliidrvriifargetevaekil

LTAE
| |.
llad
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 97-369 2.4e-48 159.9 In-house 17-284 (318) alignment 
Range on Protein: 97-369
Range on HMM: 17-284/318.0
VGVDKLREEFRGLAkytRPDMTQVMFNAnqSPDIAITKNRYQDVPCQDLSAVKLDQP---SPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVI
 |  .| ||.  |.   | . |   ...    ..  .||||...   | . |||..       .|| |||.   .  .| .| ||.|| .||..|| || 
sGelllseeyerls...rseetvtslks..lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvW

QNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLtlksGCVVENVSGSkpMERDPeIQITMLNLTYSGG-QTMSVRHLQWTEWPDRGVPPCKLTSLELLSA
. .   |||| ...| || |...|||  . ...    | .| ... .  .| .    .  ...| ..  ..  ||  ..|.|||.|||    . |.|.  
eqnsavivmltqeeergkakvhryWPskgsrsy....gklvvelkee..velsd.yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq

IRGS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
..       . |||||||||.||||. .|.. .||.|....    . . || ||.||   .| . || ||. |.|..     
vskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvD.vfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_PTPN23_pd Subfamily PTPN23 101-371 4.1e-48 158.6 In-house 16-285 (288) alignment 
Range on Protein: 101-371
Range on HMM: 16-285/288.0
KLREEFRGLAKYTRPDMTQVMFNANQspdIAITKNRYQDVPCQDLSAVKLDqPSPCNYIHANYVG--CPMIPekRFICAQGPLDQTIDEFWWMVIQNKVE
.| ..|. | ..   .  .    . .   .  .|||..|.   | . |||.  |  .|| | .|    |. |   ||..|.||..|. .|| || ..|..
aldkkfkeleqkqdkearkrsiaiak...lyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcP..dfiatqaPlqstlnDFWlmvyeqkss

QIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSgcvvENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRG---
 |||| .  |.|| |...|||...||  . .      .|. ..  | .. .. ..   | .  .. ||.|||.|.||. |||    | |..| ...    
viVmllskeelgkpkvdrYwPedkgetvkfgd....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesaye

-----SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFlEKYKE
     ||.|.|||||||.||||..  .  ..... ...  . ....|. || || |..|.  |. |   ..|..  ... .
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa.rrvld
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 97-366 1.8e-47 156.3 In-house 8-270 (281) alignment 
Range on Protein: 97-366
Range on HMM: 8-270/281.0
VGVDKLREEFRGLAKYTRPDMTQVmFNAnqsPdIAITKNRYQDVPCQDLSAVKLDQ--P--SPCNYIHANYVGCPMIpEKRFICAQGPLDQTIDEFWWMV
. .| ...||  |      |.  | ||    | .   |||| ..|| |.| |.|    |     .||||||.  |.. .. .| .|||  .|  .|| |.
mtlddfkqefsnlpgdppsdlctv.fnq...p.vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl.krgyiltqgpkketradfwrmi

IQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGskpmeRDPEIQITMLNLTYSGgQTMSVRHLQWTEWPDRGVPPCKLTSLELLSA
 |..   |||||. .|  . |||.|.|      | .    |  . |       .  .  | |||.| | .|  . |  | ||||  ||      |..|  
wqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedst.....vnkslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrk

IRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRD-QRAFSIQNDVQYLFIHRVMLNYFL
||    | |.|||||.||.||..|.|  |. |      | . ..|  ||   || |.|   ||..| .|.|.. .
irarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 133-357 2.5e-47 156.1 In-house 52-273 (301) alignment 
Range on Protein: 133-357
Range on HMM: 52-273/301.0
TKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC
 |.||. |||.  .||.. .      ||||..  .  | .|||..||||..| ..|| |..| .||.||||...||  . ||..| |   .||| ..   
dkhryptvPckPstavevivdGkrvPihanwiptsGhp.hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfk

VveNVSGSKPMERDPEIQITmLNLTYSGG--QTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPC
.  ..  .. . ..  .. | |... | |  .| .| | |..||.|||||  .    .|.  .. |. ||||||||||||. . .. ||.  .. |..| 
i..kiknkelilnkkiskrt.levedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarev.eadpt

PPMPELVKALRDQRAFSIQNDVQYLFI
  . | .| ||..|  ..|.  |  ..
ieltealkhlrehrwngvqtnsqlywm
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 133-365 1.1e-46 154.1 In-house 11-242 (250) alignment 
Range on Protein: 133-365
Range on HMM: 11-242/250.0
TKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLkCAQYWPAAQGEKLtlk
 |||| |.   | | | | . .    ..|| | ..   .   | || .|||| .|| .|| ||...|.. |||| . .|..|  . ||||. . ||    
eknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaeky...

sGCV-VENVSgsKpmERDPEIQITMLNLTYSGGQ-TMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK-----VPIVVHCSAGIGRTGTIVAIEYILE
 | | |.  |  |  |   ..... | |.    .    ||.|... |||.|||    . ||||. .. |.      |..|.||||.||.|. .||. .||
.Gdvtvslls..k..eefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

KIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
.. ..|    . ...|.|| .|  ...   || |.....|.. 
rlkkekvv.dvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPRG_pd Subfamily PTPRG 102-381 1.4e-45 150.6 In-house 21-304 (563) alignment 
Range on Protein: 102-381
Range on HMM: 21-304/563.0
LREEFRGLAKYTRPDMTQVMFNanQSPDiAITKNRYQDVPCQDLSAVKLDQPSP----CNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKV
. |||  | . | ..  .. .   | |.    |||| ..   | | ||| . .      .|| |||.      .| || .|||| .|.| || |. ...|
fseefealqsetiskdldaehs..qkpe.nkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidG.yqkskafiatqgplkdtfddFWrmiWeqnv

EQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLS---AIR
. |||. . || |. || .|||. . |..   .   .|.   . . .|   |. . |. . .  .   ||. ..|.||| |||  .|  |       | .
aiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

G-SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAALLTA-EN
     |||||||||.||||| .... .|..| ...    . ...| .| || | .|.  ||.|.| ..|.  . | .|  |  . . .|
kaeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqveelkn
0051429 (Phosphotyrosine protein) phosphatases II 157-380 1.4e-45 151.3 In-house 5-240 (272) alignment 
Range on Protein: 157-380
Range on HMM: 5-240/272.0
NYIHANYVGCP--MIPEKRFICAQGPLDQTIDEFWWMvIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENV-------SGSKPMERDP
.||.|..|| .  .. ..|.....|||. |...||..  ....  ||.|....|.|.||| .||| ..   | . . .. .           |. .  | 
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

EIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKltSLELLSAIRGsKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPP-------MPELVKAL
 .   .| |..| |... |.||..| |||.|||.     ||||....  . |..||||||..||||.||. ..|. . ..  .         . | |. |
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

RDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEKYAALLTAE
|.||. ..|.. ||||.....|... . .  ....||.| 
raqrpgavqteeqylflyeallellrsllsvraeyllaal
subfamily_Ptp69D_pd Subfamily Ptp69D 104-365 2.1e-45 150.2 In-house 26-286 (307) alignment 
Range on Protein: 104-365
Range on HMM: 26-286/307.0
EEFRGLAKYTRPDMTQvmfNANQspDIAITKNRYQDVPCQDLSAVKLDQ---PSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQI
.|.. | . . .  |.   ....  .    ||||.|.   |   ||| .       .|| |...      .|.||.||.|...||..|| |. . .|. |
keyekLeareidkstk...vsek..kenalknRyedikafDktRvkLkkingkedsdYinasfikg.ykekkkfiaaqdPveatigDfWRmiaeqevtli

VMLCKTVEMGKLKCAQYWPAAQGEKLTlksGCVVENVSGSKPME-RDPEIQITMLNLT-YSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI----R
||| .  |. . |||.|||  .  .       .|. || .|  .    |..... . .     ..  |   ..|.|.|  || .  . |.|.. .    .
vmlsnlteknrkkcakYWpiedevqyg...dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

GSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 .. ||||||||| ||.|..||.. .|... ... .  . | || || || . .|.  || |..| .|.| 
lnrsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPRA_pd Subfamily PTPRA 92-368 7.6e-45 148.2 In-house 25-298 (330) alignment 
Range on Protein: 92-368
Range on HMM: 25-298/330.0
LRALDvGVDKLREEFRGLAKYTrpdmTQVMFNANQSpDIAITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEF
 |. |    ..||||  |   .     |  ... .  .    |||. ..   | | | | . .     .|| | ..       ..|| ||||...|...|
irsad.dnklfreefnalPagp....iqatlelask.eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk.ekdkfiaaqGPkeetvedf

WWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaQGEKLTLKSGCVVENVSGSKPM-ERDPEIQitMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSL
| |. . |   |||| .  |  . |||||||  .|     .    ||..  .. .  |.  .|   |. .    ..  || . .| ||| |||      |
wrmiweqksativmltelkerkeekcaqywPd.eGlvtyGnirvevedetvlvdytvrkflvq..qlpdatrekksrlvrqfhftswPdvGvPfepiGml

ELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
.|| ...  .     |||||||||.||||| .... .||..  ..    . | || || ||.  .| | || ||..|.|.|.|  
kllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 129-366 1.4e-43 143.9 In-house 42-278 (315) alignment 
Range on Protein: 129-366
Range on HMM: 42-278/315.0
DIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEK
.|  .||||...   | . |||   |.    .|| | |.   .  .| .|..||||. ..|.|| ||.|.||  |||. |  |  |.||.||||  ... 
tinfkknryknilPldsarvkleviddsPdsdyinasyiks.vdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

LTLKSgCVVENVSgskpMERDPEIQITMLnLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYIL
  . |   || .|    .| | .  .  |  |  . ..  |   |.|||||.||.    . |.|. .....    . ...||||||.|||| ...|. ..
vefGs.ikvells....leadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

EKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
..|....    . ..|| ||..| . .| . .| ||. ..|...|
aqikrtrsv.dvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 128-366 4.8e-43 142.0 In-house 40-277 (515) alignment 
Range on Protein: 128-366
Range on HMM: 40-277/515.0
PDIAITKNRYQDVPCQDLSAVKL----DQPSpCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQG
 .|  .||||...   | . |||    |.|   .|. | |.   .  .| .|..|||.. ..|.|| .|.|..|  |.|. |  |  | ||..|||   |
eeinfkknryknilPydsvrvklevindnPh.sdyfnasyips.fdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

EKLTLKSgCVVENVSGSKpmerDPEIQITMLNLTySGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEY
. . . |   || || .     . .  .  |...  | ..  |   ..|||||.|||.   . | |. ... ..     |...|||||.|||| ...|. 
dsvkfGs.ikvelvslea....ctggikrkltvl.kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisids

ILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
.. .... .    . ..|. .|..| . .| . || ||. ..|...|
vvahakttrmv.dvfnfvtnirqkrpylvqtqeqyafiygavledll
0041856 (Phosphotyrosine protein) phosphatases II 133-369 7.5e-43 141.6 In-house 3-175 (182) alignment 
Range on Protein: 133-369
Range on HMM: 3-175/182.0
TKNRYQDVPCQDLSAvkldqpsPCNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCktvemgklkCAQYWPaaqgekltlksgc
.||||.|... | |        ...||.||.. ... . . ||..||||..|. .|. |. ....  ||.|.         . .|||             
dknrysdilpydhsr.......dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

vvenvsgskpmerdpeiqitmlnltysGGQTMSVRHLQWTEWPDRGVPPcKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKiaenkpCPP
                              .  . ..... ||| |||.   . |... ... .. |..||||||.|||||.||. .....        .
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......gvs

MPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
..| || .| .|  ....  || |.....| ..| |.
leeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_PTPN1_pd Subfamily PTPN1 131-358 8.8e-43 141.1 In-house 32-264 (290) alignment 
Range on Protein: 131-358
Range on HMM: 32-264/290.0
AITKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVGCPMIpEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQG-EKLTLK
  ..|||.||   | | .||.. .  .|| |. |  . . ....| .|||| .|.| || || ..|   .||| | || ...|||||||  .  ..|.|.
nrnlnryrdvspydhsrikleradn.dyinaslveleea.krsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellle

-SGCVVENVSgskpMERDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK------VPIVVHCSAGIGRTGTIVAIEYIL
 .   |. .|     ||  . .. .|.|.  .  .| .. |  .| ||| ||| .  . |..|  .| |        | |.||||||||.||.. .. .|
dtklkvklis....eerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtcl

EKIAENKP--CPPMPELVKALRDQRAFSIQNDVQYLFIH
 .| ...   .  . . . .|| .|   ||   |  | .
vliekkddlssvdikkvllelrkyrlGliqtadqlrfsy
subfamily_PTPRK_pd Subfamily PTPRK 132-363 2.2e-41 136.7 In-house 44-275 (314) alignment 
Range on Protein: 132-363
Range on HMM: 44-275/314.0
ITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
 .|||..|.   | | |.|      .  .|| |...     | . || .||||..|. .|| .| ...   |||| . || |..|| .|||        .
reknrsgdilaydrsrvflitidgdpssdyinaalidsykrp.aafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdi

KSGCVVENVSgSKPMERdpeiQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS----KVPIVVHCSAGIGRTGTIVAIEYILEKI
|  .|  ..  .. . |      .. .|. .  ..  ||..|.. ||| .||  . . |.|.  .  |    . .|||||||| ||||| .||. .|. |
kvelvetell.aelvvr....ifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmi

aENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
 |..    . . ||.||...   ..   || ||. |.|.
.eregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 157-375 5.6e-41 135.6 In-house 47-269 (290) alignment 
Range on Protein: 157-375
Range on HMM: 47-269/290.0
NYIHANYVGCPMipEKRFICAQGPLDQT-------IDEFWWMVIQNKVEQIVMLCKTVEMGK----LKCAQYWPAAQGEKLTLKSGCVvENvsgsKPMER
.|||||.| ||     |.|  | |. ..       | .||||. | ||.|.||||.  |  .      ||.| | . ||.|..|   | .     | .| 
dyiHAnrvtcpn..glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv.kC....kskek

DPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRA
. ....  | ... ... . | | .  .| .. |.. ..| |.|.. .. || |..|||  || |  .. ||.    |||| .    . ...|||| |||
eddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqra

FSIQNDVQYLFIHRVMLNYFLEKYKEKYAA
  |... .. |.  ... .. | ... .  
laitsalelafvdagivllaievldqfaee
subfamily_egg_pd Subfamily egg 129-367 6.6e-41 135.0 In-house 38-272 (307) alignment 
Range on Protein: 129-367
Range on HMM: 38-272/307.0
DIAITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYV-GCPMIPEkrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMgkLKCAQYWPAAQGE
|   .| | . |.|.| | |||. .      ..||||.| | |.. |  ||.|| ||  | |.|| || |..|. ||||  ..|    .|  ||| |. .
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllne..filaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesd

KLTLKSG-CVVENVSGSKpmERDPEIQITMLNLTYSGGQTMSVRHLQWtEWPDRGvppCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEK
 | .  |   .||.   .  . ||  ..| |.|  .  . . . | |. ..   .      . |..|  .|    |.||..  |. ...|.||||  | .
slvtvpGslrienlkvds..kadplfrvtklklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlskpvvvqdilGvskaatlvaieialls

IAENkPC--PPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
.    |    .. . |. || .| .|..  ..|||..|..| .| .
llrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
0046846 (Phosphotyrosine protein) phosphatases II 152-365 1.1e-40 134.6 In-house 8-173 (176) alignment 
Range on Protein: 152-365
Range on HMM: 8-173/176.0
QPSPCNYIHANYVGCPmipekRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLtlksgcvvenvsgskpmerdpeiqi
 . ...||.||.. ..     |.|. |||| .|. .|. |. ..... .|.|.. ||.|.|||..|||  .....                         
ldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

tmlnltysggqtmsvrHLQWTEWPDRGVPPCkLTSLELLSAIRGSK---VPIVVHCSAGIGRTGTIVAIEYILEkiaenKPCPPMPELVKALRDQRA-FS
                . ... ||| |||.     |||| .||       |..||||||||||||.||.  .       . . .. | .. .|.||  ..
................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel.....ekglsveealalvreqRplga

IQNDVQYLFIHRVMLNYF
.|.. || |.....| ..
vqtpeQyrflyefellll
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 100-366 1.7e-40 133.7 In-house 20-284 (290) alignment 
Range on Protein: 100-366
Range on HMM: 20-284/290.0
DKLREEFRGLAKYTRPDMTQVMFNANqspdiAITKNRYQDVPCQDLSAVKLDQPS-----PCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQ
.. |..|  | .  ..  ..| .  .       ..||....  .|   . | . |     . .||.| |.      .|..| .|||. .|. .|| .. |
egfrnqfkmldsgesehtvtvgltss.....nkllnRfanivvyddnritLrpisghkDCtneyinAcyikg.ykekkqyiatqgpvsntlvdFWkliwq

NKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSkpmeRDPEIQITMLNLTYSgGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI-
.||  ||||.. .|.|| || ||||... ...   |  .... . .    .  |... . | . . |.. || ..| | |.. |  ... |.| ... . 
ekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln....eyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemy

----RGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
    .  . .||||||...||... .|..  ..|   .     . ...| .| |.  |.|  .|| .|....|.|. 
ktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvi.dvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 98-366 5.8e-40 132.5 In-house 32-292 (319) alignment 
Range on Protein: 98-366
Range on HMM: 32-292/319.0
GVDKLREEFRGLAKYTRPDMTQVMFNANQSPDiaitKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEkRFICAQGPLDQTIDEFWWMVIQ
 . ||. ||| ..| . .  .|   | .|  |    |||. ..   | . |||..       .|| | .|     .. ..| |||||| |...|| |. .
dltklevefrracklgvnladqtfanldqnkd....knriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPldntladfWrmiwe

NKVEQIVMLCktvemgKLKCAQYWPAAQGEKLTlKSGCVVENVSGSKPmerdpeIQITMLNLTYSGGQ--TMSVRHLQWTEWPDRGVPPCKLTSLELLSA
 ..  ||.|       | ||.||||    .|   .    |. |  ..         .  ..|.  | .    ...   .  ||| |||      . |.  
yncstivllt......kdkcsqywplkivikee.rfkvkvdsveetae......yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

------IRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
          . .||||||||.||||. .... .|... |.|    . ..|. ||.||   .|. ||| ||.  .|. .|
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 110-367 1.4e-39 130.8 In-house 20-272 (285) alignment 
Range on Protein: 110-367
Range on HMM: 20-272/285.0
AKYTRPDMTQVMFNANqsPDIaitkNRYQDVPCQDLSAVKLDQpSPCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEM
  |  |. |   ..||  ||.    ||| || | . . | | .    .||||...  |   .  .| .|||| .|. .|| |. |.|.  ..|||  .| 
kgymppnctytayean..pdl....nryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeg

GKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAI---RGSKVPIVVHCSA
|  ||| |.|   || . .    .       . .       .|..|   .  . . . |.|   |||.  |      .||   .      . ||.|||||
gvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsa

GIGRTGTIVAIEYILEKIAENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
|.||| |.| |.|   .| || |   | ..|. .|  |  ..|. .|.||.. |...||. 
gvgrtatfvgidyatirimen.pniemldivremramrfqavqshmqflflyvvlmeyfig
0036282 (Phosphotyrosine protein) phosphatases II 157-359 2.3e-39 130.2 In-house 3-164 (174) alignment 
Range on Protein: 157-359
Range on HMM: 3-164/174.0
NYIHANYVGCPMIPEkRFICAQGPLDqtideFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAaqgekltlksgcvvenvsgskpmerdpeiqitmlnl
.||.|....  .|.. |.|. ||||.     || |. ..... .|||.. .|.|. || .|||                                     
dyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tYSGGQTMSVRHLQWTEWPDRGVPPCKLtSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAenKPCPPMPELVKALRDQRAFSIQND
 ..   . .. ..... |||.|||.     ||......       . |..||||||.|||||.||. ..|  .    .     .||..|| ||  ..|..
.lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtp

VQYLFIHR
 || |.. 
sQyrflyy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 108-364 3.3e-39 129.5 In-house 14-265 (283) alignment 
Range on Protein: 108-364
Range on HMM: 14-265/283.0
GLAKYTRPDMTQVMFNANQSPdiaiTKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVG--CPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCK
 | . . ||.  ..  |.. .    .|||.|..  .|   |.|.  |. .|| | ..        .|..| ||.|||.|. .|| || ..|.  |||| |
vlkrlsvpdldadiasadenk....rknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

TVEMGKLKCAQYWPAAQGEKLTLKSgCVVENVSGSKPMErdpeIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPcKLTSL---EL-LSAIR-GSKVPI
  |  . ||.||||    |.        ...  .|. .     |.  .|.   |  .|. . | |  .| . |  .  . ||   ..  |  .   | ||
lqedlrikCsqyWPkrGsedyGeft.vtlrkettsnsfi....ikelllrvnssakstlllahyqvidWleygeqa.iinslvkfnkvislqteskkgPi

VVHCSAGIGRTGTIVAIEYILEKIAeNKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
|||||.|||||.. .|.   ....   .    ... || .| ||   .|.  || ..| ..|. 
vvhCstgiGrtavfiaasasvkdal.tesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 135-372 6.4e-39 128.5 In-house 47-283 (312) alignment 
Range on Protein: 135-372
Range on HMM: 47-283/312.0
NRYQDVPCQDLSAVKLDQPSpCNYIHANYVGCPMIPEkRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGeKLTLKSGCV-
||| .. | |     |       |||||.|     || ||.|.||||..|.  || ...      |..||  || |  |||.|     |  . |.   | 
nrypniqcwdrgrftlagde.nfyihanfvkictkpe.rfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivg.fvdledhrvy

----VENVSGSKPmeRDpEIQITMLN-LTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENK
     |   | |   .|  |   .|. .  . ||   . | ||. ||| |.|    |.| ||||..  | |.. |||||.|||||.. || ..  .   .
teycteieiggks..kd.kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr

PCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEK
    . .    || .|| |..   ||..  |..|...  |   |
kq.nvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 105-366 1.5e-38 127.9 In-house 3-256 (284) alignment 
Range on Protein: 105-366
Range on HMM: 3-256/284.0
EFRGLAKYTRPDMTQVMFNANQSPDiaitKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEkRFICAQGPLDQTIDEFWWMVIQNKVEQIV
||| ..| . .  .|   | .|  |    |||. ..   | . |||..       .|| | ..     .. ..| .||||| |...|| |. . ..  ||
efrracklgvngtdqtfanldqnkd....knrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstiv

MLCktvemgKLKCAQYWPAAQGEKLTlKSGCVVENVSGSKPmerdpeIQITMLNLTYSGGQ--TMSVRHLQWTEWPDRGVPPCKLTSLELLSA------I
.|       | ||.||||    .|   .    |. |. |.         .  ..|.  | .    ..|   .  ||| |||      . |.         
llt......kdkcsqywplkivikee.rfkvkvdsveesee......yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltsk

RGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
   . .||||||||.||||. .... .|... |.|    . ..|. ||.||   .|. ||| ||.  .|. .|
enhranivvhcsagvgrtgvyivldvlldrmkeekqvd.vynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 132-366 2.1e-38 127.0 In-house 50-280 (315) alignment 
Range on Protein: 132-366
Range on HMM: 50-280/315.0
ITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAqgeKLTL
  |||| ..   | | |.|   .. . ..|. ||..     . .|.|.||||. .....|| .| .... .|||| ..||  | |. .|||     |.. 
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkk.rryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviy

KSGCVVenvsgSKPMERDPEIQITMLnLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR----GSKVPIVVHCSAGIGRTGTIVAIEYILEKI
    |       |  |   |. .  |  . .| .   |  |..| ||| |||   .. ..|   ..     |  .||||||||.||||| .... .|...
Gkitvt.....rkseevnteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqa

AENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
  ..    . .... .|..|   .|   || ||. ..|. |.
eaenai.dvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_PTPN14_pd Subfamily PTPN14 130-365 3.2e-38 126.4 In-house 48-296 (300) alignment 
Range on Protein: 130-365
Range on HMM: 48-296/300.0
IAITKNRYQDVPCQDLSAVKLDQP--SPCNYIHANYVGCPMIPEK-RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
    |||..||   . . |.|     .  .|| |  .  ..  ..  .| |||||..|. .|| || ...|. |||| .. | || |. .|.|  . .| 
enaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkk

TLKSGCVveNVSgSKPMERDPEIQITMLNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIR-------------GSKVPIVVHCSAGIGRTG
|.. |    .|. .|  |  . .  | |.| .   ..  .| |||.|.|||.|||.   . |. |  ..              || |..||||||.||||
tvefgkf..kvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

TIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 ..  . ... .  |.    ... .. || || . .|.  || |...|...|.
vlilsdlliatlehneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikyl
0043147 (Phosphotyrosine protein) phosphatases II 156-358 8.7e-38 125.1 In-house 5-154 (172) alignment 
Range on Protein: 156-358
Range on HMM: 5-154/172.0
CNYIHANYVGCPMIPEKrFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTvemgklkcaqywpaaqgekltlksgcvvenvsgskpmerdpeiqitmln
..||.|.|. .. || . ||. ||||. |...|| |. ....  ||.|..                                                  
sdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.................................................

LTYSGGQTMSVRHLQWTEWPDRGVPpCKLTSLELLSAIRG-----SKVPIVVHCSAGIGRTGTIVAIEYILEKIaenkpcpPMPELVKALRDQRAFSIQN
|..  . . .. ..... ||| |||      ||.|. |.      .. |..||||||.|||||.||. ..|...       .. | |. .|..|  ..||
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllgl.......sleeavalvrekRpgavqn

DVQYLFIH
. || |..
psqyrfly
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 133-362 5.5e-37 122.2 In-house 5-236 (237) alignment 
Range on Protein: 133-362
Range on HMM: 5-236/237.0
TKNRYQDVPCQDLSAVKLDQP-SPCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKltlKSG
 |||| .. . | | | |  . | ..|| |.|.       |..|.|||||. . |.|| || |.|   ||||   .|  .||| .||| ..  .     |
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa...ayg

cvVENVSGSKPmERDPEIQITMLNLTYSGGQ--TMSVRHLQWTEWPDRGVPPCKLTSLELLSAI-RG-----SKVPIVVHCSAGIGRTGTIVAIEYILEK
  |  ||  |  |   .  .  | |.. . .     .   |.| |||||||    . | .   |           | ..|||||.|||| .. |. .| .
..vltvslkkk.eefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVML
  |.|    . . |... ..| . ||   ||.|||...|
akekk.vvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 103-366 6.1e-37 122.0 In-house 13-278 (287) alignment 
Range on Protein: 103-366
Range on HMM: 13-278/287.0
REEFRGLAKYTrpDMTQVMFNANQSpDIAITKNRYQDVPCQDLS--AVKLDQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQI
 .|.  | . .  . . ..| | .    |. |||| ||   | .   .  .     .|| ||||      ...||.||||.  |. .|| .|.....  .
dkevdalkeds..esstatfkaaee.laavkknryadvlPiddtrvllsaegelGsdyinanyvas.ytddeafiaaqgPiaatvrdfwravletrsasv

VMLCKTVEMGKLKCAQYWPAAqgEKLTLKSGCVVENVSGSkpmERDPEIQITMLNLTYSGGQT-MSVRHLQWTEWPDRGVPPC--KLTS--LEL---LSA
... . || ..||| .|||    |.  .  |  |  .. .    ..||  .  | |    ..    |. |.. .|||....|    |    |.    . .
itmtreveearlkcykywPer..evPmrvGGysvvlldyd...ikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhiel

IR-GSKV-PIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
 | .|.| |.|||...||||.|...|.  ....  .      .   |  || .||  .|  ||. ..   .  |. 
ardasevGPlvvhddvGiGrsGillatlvlvsrledlGrv.dvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 133-365 9.1e-37 121.6 In-house 49-278 (287) alignment 
Range on Protein: 133-365
Range on HMM: 49-278/287.0
TKNRYQDVPCQDLSAVKLDQPSPcNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGC
 |||....  .|   | | .  | .|| | ..      .|.|| |..|. .|. .|| .. ...|. |||||.  |  . .| ||||  .   |   .  
dknRltqilvpdnyrvllkgehp.dyinavfidg.ykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeynie

VVENVSGSKPMERdpEIQITMLNltySGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSA-----IRGSKVPIVVHCSAGIGRTGTIVAIEYILEKiAEN
....   .. .||  .....  |   . |.. .|.  | |.|...|  ... |.| ..        . .. .||||||...||... .|..  ..| ...
llneevnagyier..klevknkn...kagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink.ckt

KPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
     . ...|  | |.  |.|   || ||  ..|.| 
eGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 128-368 6.4e-36 119.0 In-house 48-287 (297) alignment 
Range on Protein: 128-368
Range on HMM: 48-287/297.0
PDIAITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIpekRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGE
  . . |.||...   | | |||         .|. | .|        |.|. | | ..|...|| ||....|  |||| .  |  | |||.||.     
kkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvt

KltlkSGCVVENVSgsKPMERDPEIQITMlNLTYSG-GQTMSVRHLQWTEWPDRGVPP--CKLTSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVA
.     | |.  ..     ||   |. .. ..| .   ..  |.  |..||||. |.      . |.|.| .| .     . |..|||.||.|||| ...
t....fGdvsvvll..svsereGfikrel.evtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllt

IEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEK
|. .. .. ..|    . .||| ||..| . .| . || |.. ..|...| .
idsvvaeakrekevd.ifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 131-280 1.2e-35 117.9 In-house 33-180 (297) alignment 
Range on Protein: 131-280
Range on HMM: 33-180/297.0
AITKNRYQDVPCQDLSAVKLDQ-PSPCNYIHANYVGCPMIPEK-RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
.. ||||.|.   | . ||| . ..  .|| |.||  |  ... ..|.|||||..|.|.|| .| .. |  |||..|  | |. ||| ||| ...|.|. 
slrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka

KSgCVVENVSGSKpMErDPEIQITMLNLTYSgGQTMSVRHLQWTEWPDRGVP
 .  ||| .|     |    ...| |.| |   ..  ||| |.  ||| |||
gd.vvveflssts.de.fdrviltelqliyr.sesrvvrhvqflswpdhGvp
0049260 (Phosphotyrosine protein) phosphatases II 171-358 3.8e-35 116.2 In-house 8-143 (152) alignment 
Range on Protein: 171-358
Range on HMM: 8-143/152.0
EKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWpaaqgekltlksgcvvenvsgskpmerdpeiqitmlnltysggqtmsvrHLQ
 ..||..|||...|...|| |. ....  ||||.. .|.|||||.||.                                                 . .
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qyl

WTEWPDRGVPPCKLTSLELLSAI----RGSKVPIVVHCSAGIGRTGTIVAIEYILekiaenkPCPPMPELVKALRDQRAFSIQNDVQYLFIH
.. ||| |||.     |.|| .|    . .. |..||||||.|||||.||. ..|          .. | |. .| .|  ...|  |. |..
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 112-363 9.1e-35 114.9 In-house 31-277 (439) alignment 
Range on Protein: 112-363
Range on HMM: 31-277/439.0
YTRPDMTQVMFNANQSPDiaITKNRYQDVPCQDLSAVKL-DQPS--PCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVE
 |.|| . .   | |. |   |||||.||   | . | | . |      || |||.      .| .| .||| ..| |.|| .||..|. .||||.. ||
stspdyaciaslaaqeyd..qtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkkettddfwrlviekktvtivmltnlve

MGKlkcaqYWPAAQGEKLtlksGCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-----KVPIVVH
  |     |||. .        | ..  |     . .     . ..|   .. .  .| ..... |||. ||      |..| ||  .       |.|||
syk.....ywpsdaevcy....gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvh

CSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLN
||||.||||||.|..  ||..  ..    .  .|| ||.||   .|. .||.||.  .|.
csagvGrtGtiialdialeqlklenkv.dikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 117-367 1.7e-33 111.2 In-house 35-290 (325) alignment 
Range on Protein: 117-367
Range on HMM: 35-290/325.0
MTQVMFNANQSPDiAITKNRYQDVPCQDLSAVKLD---QPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKvEQIVMLCKTVEMGKLK
   . ...   |.  . |||...|   | | | |    . . ..|| |.|.    .  . |. || || .||...| .|.. .   .|..   .. || .
ddgiakkvamkpe.nkaknrfknvvaldksrvvletkkddpssdyinasylrd.dkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdr

CAQYWPAAQGEKLTLksGCVVENVSGSKPMeRDpEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVP--PCKLTSL-ELLS----AIRG---SKVPIVVH
||.|||   |.  |.  | .  ..   . .  |  ..  .     ..|.|.||. .|.  |.| ||.  |. | |. .|.      ..    .  ||.||
cavywpkemgksktf..Gglevklrtieei.sd.yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvh

CSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
||||.||||. ...  .|.|. |.     . . || || .|   ..   || .|.  . .... 
csaGvGrtGvfislysalakvieesrv.difgfvkklrkdrpsmvetvdqyiliyealveayms
0049772 (Phosphotyrosine protein) phosphatases II 132-368 3.4e-33 111.1 In-house 47-283 (314) alignment 
Range on Protein: 132-368
Range on HMM: 47-283/314.0
ITKNRYQDVPCQDlSAVKLDQ--PSPCNYIHANYVGCPmipeKRFICAQGPLDQTIDEF----------WWMVI--QNKVEQIVM---------------
..||||.|... | . |.|.    | ..||.|.|| ..    ..||..||||. |.. |          | ||.  ...|  |||               
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------LCKTVEMGklkcaQYWPAAQGEKLTlksgcvvenvsgskpmE-------RdpeiqitmlnltysggqTMSVRHLQWTEWPDrGVPPCKLTSLEL
      |..  . |      ...||  | |                 |                         .  . .. .. .|| | .|     .|.
AlgKtpllildgng.....neptaadlellk................eelydpelf.................erlgikylripvpD.gsaplledfdef

LSAIRG--SKVPIVVHCSAGIGRTGTIVAIEYILEKIaenkPCpPMPELVKALRDQRA-----FSIQNDVQYLFIHRVMLNYFLEK
| .|.    . |..|||.||.||||| |.. |.. .      . .. | .. .| .|       .|..  ||.||....|.|.  .
lefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 101-365 1.5e-31 104.3 In-house 16-293 (301) alignment 
Range on Protein: 101-365
Range on HMM: 16-293/301.0
KLREEFRGLAKYTrPDMTQVMFNANQSPDIAITKNRYQDVPCQDLSAVKLDQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQI
|. |... | ... .. ..| .. ....     .. . |     |.  .  . .  .|| |.|.   .  .|.|| ||||...|. .|| ...|.|. .|
kfeeqykelkege.dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidg.ysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLCKTVEMGKLKCAQYWPAAQGEKLTLK-------SGC-----V-------VENVSGSKPMERDPEIQITMlnltysggQTMSVRHLQWTEWPDRGVPP
||.... |  | || |||| .. |. .         . .     |       ....|. . .||  ... ..        ....|  || |.||. || .
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk........sswdvlqlqvtdWpqdGvvr

CKLTSLELL-----SAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
 . | |. .        . .. |.|||||....|.|. ....  ||    .     . ...||.| ..   ..   || .|. |.  |.
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaeg.VVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 125-366 1e-30 101.5 In-house 39-237 (392) alignment 
Range on Protein: 125-366
Range on HMM: 39-237/392.0
NQSPDIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGklkcaqywpaa
    .| . ||||...   | . |||   |. .  .|. | |. . .  || .|..|||   ..|.|| || |..|  |.|. |  |             
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyips.fdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

qgekltlksgcvvenvsgskpmerdpeiqitmlnltySGGQTMSVRHLQWTEWPDRGVPPCKLTSLEL---LSAIRGSKV-PIVVHCSAGIGRTGTIVAI
                                      | .. .|   ..|||||..||    . |..   ..|  |.   |...|||||.|||| ...|
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

EYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
. .. .  . .    . ..|  .| .| . .| . || ||.  .|. .|
dsvvahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygavledll
subfamily_ptpA1_pd Subfamily ptpA1 99-324 1.3e-30 101.5 In-house 20-256 (418) alignment 
Range on Protein: 99-324
Range on HMM: 20-256/418.0
VDKLREEFRGLAKYTRPDMTQvmfnaNQSPDIAITKNRYQDVPCQDLSAVKL---DQPSPCNYIHANYVGCPMiPeKRFICAQGPLDQTIDEFWWMVIQN
. |..|||| | .   |  |      .       .|||| ..   . . |.|   ..    .|| |||.     | |.|||.|||| .|| .|| || .|
ihkikeefrlleesvgpsets.....egdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.p.kqfictqgplpntiadfwrmvwen

KVEQIVMLCKTVEMGKLKCAQYWPAAQ-GEKLTLKSGCvvENVSGSKPM-----ERDPEIQITMLN--LTYSgGQTMSVRHLQWTEWPDRGVPPCKLTSL
..  |||| .  |  ..|| .|||    ||....      ..| |.  .      .||| .|   |  ||.  |.|  . . |.  |||. .|       
rcriivmlsresencrikcdrywpeqiggeqfsiygng..nevfgtysvelveviqdpereiitrnirltfe.getrditqyqyegwpdhnipdhtqpfr

ELLSAIRG----------SKVPIVVHCSAGIGRTGTIVAIEYILEKI
.|| .|             .|||.||||||.|||||...   ...|.
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_PTPRN_pd Subfamily PTPRN 100-359 3.7e-30 99.7 In-house 29-286 (297) alignment 
Range on Protein: 100-359
Range on HMM: 29-286/297.0
DKLREEFRGLAKYTRPDMTQVMFNANQspdiAITKNRYQDVPCQDLSAVKLDQPSP---CNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNK
|.|..|. .|..|   . |. . .|..    ...|||...|   | | |||.. .     .|| |  .      .  .| .|||| .|. .|| || .. 
drlekewealcayeaepstkevakaek....nvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

VEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL-KSGCVVENVSGSKPMERdpeiQITMLNLTYSggQTMSVRHLQWTEWPDRGVPPCKLTSLELL----S
|  ||.|..  | |  .|..|||    |   . .   | | .     . |     . . ||  |  .| .|  . .  ||..|||.   . ||.      
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvr....sfylknlqts..etrtvtqfhflswpeegvPasaksllefrrkvnk

AIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHR
. ||   |||||||.| ||||. ..|. .|....       .   .. |||||.  ..   |. |.  
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalt
0051082 (Phosphotyrosine protein) phosphatases II 157-361 5e-30 99.5 In-house 4-149 (151) alignment 
Range on Protein: 157-361
Range on HMM: 4-149/151.0
NYIHANYVGcpmipeKRFICAQGPLDqtidEFWWMVIQNKVEQIVMLCKTVEMGklKCAQYWPAAQgekltlksgcvvenvsgskpmerdpeiqitmlnl
.||...||.       .... .|||.    .|. .. ....  ||.|....|.|  .|..|.|...                                  
dyinfsyvt......gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

tysggqtMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-KVPIVVHCSAGIGRTGTIVAIEYILEKiaenkpcPPMPELVKALRDQRAFSIQNDVQYL
       . |.|.... ||| |.| .  . ||.|....   . |..||||||.|||||.||.  .|..        .. | .. .| .|  ..|   |.|
.......ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

FIHRVM
|.....
fqlfal
PTPc_DSPc_SM00012 266-362 8.4e-30 98.5 In-house 2-104 (105) alignment 
Range on Protein: 266-362
Range on HMM: 2-104/105.0
VRHLQWTEWPDRGVPPCKLTSLELLSAIRGSKV------PIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHR
|.|...|.||| |||      |||| |.. .|       |.|||||||.|||||.||....|... ... .. . ..||.||.||. ..|.. ||||..|
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VML
..|
all
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 132-362 2e-29 97.4 In-house 8-237 (239) alignment 
Range on Protein: 132-362
Range on HMM: 8-237/239.0
ITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
 .|||| ..   | | | |.. |     .|| |.|.       | .|..|| .  .  .|| |. |..   ||||   .|  | || |||| .  .   |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

KSGCVVENVSGskpmerDPEIQiTMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKI
.      .|        |  |. |..       .   | . ..| |||.|||    . | |   |         | |.|||||.||||... |. .| . 
rvtlrktevfa......dyiir.tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

AENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVML
 ..|    . . |||.|..| . .|   ||.|||  .|
kkqktv.difnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 132-362 2.3e-29 97.2 In-house 9-238 (239) alignment 
Range on Protein: 132-362
Range on HMM: 9-238/239.0
ITKNRYQDVPCQDLSAVKLDQPS---PCNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTL
 .|||| ..   | | | |.. |     .|| |.|.       | .|..|| .  .  .|| |. |..   ||||   .|  | || |||| .  .   |
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl

KSGCVVENVSGskpmerDPEIQiTMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGSK----VPIVVHCSAGIGRTGTIVAIEYILEKI
.      .|        |  |. |..       .   | . ..| |||.|||    . | |   |         | |.|||||.||||... |. .| . 
rvtlrktevfa......dyiir.tfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

AENKPCpPMPELVKALRDQRAFSIQNDVQYLFIHRVML
 ..|    . . |||.|..| . .|   ||.|||  .|
kkqktv.difnyvkairedrphmvqtseqyvfihlavl
0044763 (Phosphotyrosine protein) phosphatases II 153-365 1.2e-28 95.3 In-house 15-171 (178) alignment 
Range on Protein: 153-365
Range on HMM: 15-171/178.0
PSPCNYIHANYVGcpmipEKRFICAQGPldqtiDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGekltlksgcvvenvsgskpmerdpeiqit
.  . ||.|...      .  ......|      ... .. ....  ||.|....|.|.||| .|||   |                             
lersdyinaseil.....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

mlnltysggqtmsvRHLQWTEWPDRGVPPCKLTSLELLSAIR----GSKVPIVVHCSAGIGRTGTIVAIEYILEKiaenkpCPPMPELVKALRDQRAfSI
               . ... .|| |||.     ||.. .|.     .. |..||||||.||.||.||. ....         ...| .. .| .|   .
..............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.iv

QNDVQYLFIHRVMLNYF
.|. |. ..... | ..
pnpgqlrqLyefelrll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 184-374 9.7e-28 91.9 In-house 40-232 (255) alignment 
Range on Protein: 184-374
Range on HMM: 40-232/255.0
TIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIqitmlNLTYS-GGQTMSVRHLQWTEWPDRGVPPC
|.|.|. ...|.| |..||||   | |. || .|.|  . ||| |.   |.   | .... |  ||      .|..   .|  |.| ... |...  |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtlei.....tstlgekkkthtvkhysykGWieknaPel

KLTSLELLSAIRGSKvPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPP-----MPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL--EKYKEKYA
    |..| ..| || ..|||||.||||. . | .|..  |.  .    .       .|.. || .|. .|.. .|  |   ..|...   .....|| 
areilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgeleakyq
subfamily_CG7180_pd Subfamily CG7180 150-367 5.4e-27 89.2 In-house 64-292 (296) alignment 
Range on Protein: 150-367
Range on HMM: 64-292/296.0
LDQPSPCNYIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEI
||  .  .|| | ||   .. .| .|  ..| ..|.|||| .| ..... .|.|.|| .. | .. .|||  . |.       .||. . ..   |   .
ldGeeksdYinavyvds.flkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkl

QITMLNLT----YSGGQTMSVRHLQWTEWPD-RGVPPCKLTSLELLSAIRG--SK-------VPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPE
. ... ||        .|  |...|.|||.    ||    . .||.  .|    |        |.||..| | .|.|  .||.  ||.. ... .  . |
tkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekee.evdvFe

LVKALRDQRAFSIQNDVQYLFIHRVMLNYFLE
 || || .|   ..|  .| .|  |.|...| 
avktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_hpo-7_pd Subfamily hpo-7 181-372 5.2e-26 86.1 In-house 43-234 (263) alignment 
Range on Protein: 181-372
Range on HMM: 43-234/263.0
LDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDPEIQITMLNltysGGQTMSVRHLQWTEWPDRGVP
| ||||.|. .. |.| |..||||   | |. || .|.|  . ||. |.   |.   . |... .  |.  |. .      .|  |.| ... |...  |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge....KkkthtvkhysykgWiekndp

PCKLTSLELLSAIRGSKvPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPP-----MPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKEK
     .|..| . |.|| ..|||||.||||.   . .| .  |.  .    .       .|.. || .|. .|.. .|  |   ..|...|. . . 
elareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakg
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 180-370 1.7e-25 84.1 In-house 99-293 (302) alignment 
Range on Protein: 180-370
Range on HMM: 99-293/302.0
PLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVvENVSGSKPMERD-PEIQITMLNL-----TYSGGQTMSVRHLQWTE
|  .|.. .| .. | .|  .| ||. || .. |||.|.    |..|...  .| . ||  . .|.     .... ..          . ..|  |... 
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytv.ktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDRGVPPCKLTSLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYK
||| | |    |.|..|      |  ..||||||.|||||.||| | ..  ...|    . ..|. .|. |  ..|.. | ...  ..   ..||  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkk.vtdllsivlpvrqcryGavqdeqqliylllcvtkglmekag
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 132-371 8.5e-25 81.8 In-house 52-291 (302) alignment 
Range on Protein: 132-371
Range on HMM: 52-291/302.0
ITKNRYQDVPCQDLSAVKLDQpSPCNYIHANYVGCPMIPeKRFICAQGPLDQTI---DEFWWMVIQNKVEQIVMLCKTVEMGKlKCAQYWPAAQGEKLTL
. ||. .|||. |   |||.. .| .|..|  |  | .  .  | || |  ..    .||| || |.|. ..|.| .. |. |    ...|  .|. .. 
lkknqsedvpildsnlvklea.epdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykey

KSgCVVENVSGSKPMERDPEIQITMLNLTYSGGQTMSVRHLqwTEWPDRGVPPCKLTSLELLSAI----RGSKVPIVVHCSAGIGRTGTIVAIEYILEKI
..   | |   .|  |   .  | .|   .|    ..| .|  | |..  ||    .  .    .      .. ..|.    |.|| |....    .||.
gk.mfvNnrkVekaeeektryviEvlPegcsnsvlanvyvl..tnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavavekl

AENkPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKYKE
 ..   | . |.||..| ||. ....  || ......| |...| ..
qkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 133-366 1e-23 78.7 In-house 35-260 (267) alignment 
Range on Protein: 133-366
Range on HMM: 35-260/267.0
TKNRYQDVPCQDLSAVKLDQpSPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTvEMGklKCAQYWPAAQGEKLTLKSGc
 .||..|.   | . | | . .  .|| | || .    .. ||  |.||..|| .|. .....||  ||.| |.  ..  .  ..||   |.    .   
ernrlddnlpyddtrvilrt.keeeyinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkv.ftd..nirlfwPPkmgqakkyqdl.

VVENvSGSKpmeRDPEIQITMLNLTYSGGQTMSVRHLQWTEWPDRGVPPCKLTSLE-LL--SAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKp
.||  |  |    . . ||  |.| .    .  |    . .|         |  |  .|    .     |.||.||.|.||.|| . |.  ||.. ..  
tveh.slek...eendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakteg.

CPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFL
   . .... .|.||   ..   .|..||... .|  
vsdifdflrkirsqriglvdtkeryiyihellaeyae
0048076 (Phosphotyrosine protein) phosphatases II 249-362 5.1e-21 70.3 In-house 28-140 (145) alignment 
Range on Protein: 249-362
Range on HMM: 28-140/145.0
IQITM-LNLTY-SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS---KVPIVVHCSAGIGRTGTIVAIEYILEkiaenkPCPPMPELVKALRDQ
 .||. ||||.   . .  . ..... |||.|||.   . ||.| .|.     . |..||||||.|||||.||.  .|.         ...| .. .| |
lgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsq

RAFSIQNDVQYLFIHRVML
| ....|. |. |.... |
rpgavpnpgqlrflyefel
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 104-369 2.2e-20 67.5 In-house 26-283 (303) alignment 
Range on Protein: 104-369
Range on HMM: 26-283/303.0
EEFRGLAKYTRPDMTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDQPSpcnYIHANYVGcpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVML
.||  .. |  |....  |  |      . |||. || | | | ||| . |   ||||.|.   .  .|. | .| || .|  .|| |.|..||  ...|
nefekvvsylppsvsknqfvkn......mdknrfvdvicldhskvklsdss...yihasyle..ldsskkailtqlplshtaadfwqmiieqkvkcvlll

CKTVEMGKLKCAQYWPAAQgEKLTLKSGCVveNVSGSKPMERDPEIQITMLNLtySGGQTMSVRHL-QWTEWPDRGVPPC---KL--TSLELLSAIRG--
    |. ||     .|  | . | ..   .   |   | .|     .. .| .  | |.  |  |. .. .||   .|     |.     .| | .|   
ltdseydklggdsvfprnq.dflkfeersi..rvgefkrvelgdgwvlkvlsv..sngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys

SKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYFLEKY
   | |    .| ||.||.  .|     . .....  .   .. .|. |  ..||  |. ... .. .. |.. 
dstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng
0048179 (Phosphotyrosine protein) phosphatases II 255-359 4.9e-20 67.2 In-house 48-139 (144) alignment 
Range on Protein: 255-359
Range on HMM: 48-139/144.0
NltysggqtmsVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS---KVPIVVHCSAGIGRTGTIVAIEYILekiaenKPCPPMPELVKALRDQRAFSIQND
.          . ..... |||.|||.     ||.| .|.     . |..||||||.|||||.||.  ..      |   .. | .. .| .| ....|.
e..........giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpgavpnp

VQYLFIHR
 |. |...
gqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 132-243 6.2e-19 62.9 In-house 48-175 (350) alignment 
Range on Protein: 132-243
Range on HMM: 48-175/350.0
ITKNRYQDVPCQDLSAVKLD-----------QPSPCNYIHANYVGCP-----MIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCA
 .||||...   . | |||              |. .|| |||.  .     . |. ..| .|.|| .|.|.|. ....|||. |..| . ||..  || 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPAAQGEKLTLKSGCVVENVSGSKPM
.||.  . .. |.|     ||. | . .
rYWqegsydditvklaskwenimginds
subfamily_CG42327_pd Subfamily CG42327 116-292 9.2e-18 59.0 In-house 13-189 (319) alignment 
Range on Protein: 116-292
Range on HMM: 13-189/319.0
DMTQVMFNANQSPDIAITKNRYQ-DVPCQDLSAVKLDQPSP--CNYIHANYVGCPMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKL
|. |.. .|.. |  .  |.|.   ||  . ..|   ...    .|..|.||  .   .  .|.|| .|...  .|| .| ...   || |..  | |  
dlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGik

KCAQYWPAAQGEKLTLKSGCVVENVSGSKPMERDpeIQITMLNLTYSGGQTMSVRHLqWTEWPDRGVPPCKLTSLELLSA
.||.|.|. .. . |   | .   . | .  .|   .  |.|     . ..  . |  | .|.. .||  . . . .|  
vcaeylPtketldntslyGdilvtlkgrevkdry..aistlllkrvdkeesrelthy.wykwleaevPaeeaaliamlle
subfamily_CG42327_pd Subfamily CG42327 291-364 1.5e-16 55.0 In-house 241-314 (319) alignment 
Range on Protein: 291-364
Range on HMM: 241-314/319.0
SAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
|. | |. |.||||| |.||||...| .  .... |.|    .|.||  .| .|| ....  || ||..|. .|
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 171-359 5.3e-15 50.1 In-house 4-198 (199) alignment 
Range on Protein: 171-359
Range on HMM: 4-198/199.0
EKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVenvsgSKPMERDPEIQITMLNLT---YSGGQTMSVR
..|.|..| || .|. .|| || .    .|||.       .   . |||...       | .|.     .| .   |.  || | ||    .   |  . 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt.....tktittkpdytitaliltnnttappstreis

HLQWTEWPDRGVPPCKLTSLELLSAIRGS-------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPC-PPMPELVKALRDQRAFSIQNDVQYLFIHR
| |.| | ..  |   |    ....   |         |..|||| | | || .||..  .    | |     . |. | ||. |   |    .| ||..
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 172-359 5.5e-15 50.1 In-house 4-197 (198) alignment 
Range on Protein: 172-359
Range on HMM: 4-197/198.0
KRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVenvsgSKPMERDPEIQITMLNLT---YSGGQTMSVRH
.|.|..| || .|. .|| || .    .|||.       .   . |||...       | .|.     .| .   |.  || | ||    .   |  . |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvt.....tktittkpdytitaliltnnttappstreish

LQWTEWPDRGVPPCKLTSLELLSAIRGS-------KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPC-PPMPELVKALRDQRAFSIQNDVQYLFIHR
 |.| | ..  |   |    ....   |         |..|||| | | || .||..  .    | |     . |. | ||. |   |    .| ||..
yqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 146-236 2.1e-14 47.6 In-house 80-171 (349) alignment 
Range on Protein: 146-236
Range on HMM: 80-171/349.0
SAVKLDQPSPCNYIHANYVGCPMI-PEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKSGCVVEN
|  . |   . .|| |||.  . | .||..|. | ||  |.|.|. ... |.|. .. | .  | .  || .||   . .  |.|     ..
stsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnssly
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 286-364 1.9e-13 44.9 In-house 217-294 (297) alignment 
Range on Protein: 286-364
Range on HMM: 217-294/297.0
SLELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNY
 || | |    .....||||||.||.| .|  . ||.|.  .|  | .  ... ||.|||  .|   |. ... ..|. 
qleslraemprnayllvhcsaGvGrsGvvvlsdvilakl.rkkripdvaailsilreqrarlvqtleqfellydavlkk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 259-365 1.3e-12 41.8 In-house 84-194 (440) alignment 
Range on Protein: 259-365
Range on HMM: 84-194/440.0
SGGQTMSVRHLQWTEWPDRGVPPCKLTSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKPCpPMPELVKALRDQRAFSIQNDVQ
.| .. .... ..  |||.|||      |...  .  |     . |..|||||| |||| |.|.. || .   .     .  .....|..|   .|   |
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqtpeq

YLFIHRVMLNYF
| |.| ..|. .
yafvheavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 296-365 1.3e-12 42.1 In-house 261-344 (350) alignment 
Range on Protein: 296-365
Range on HMM: 261-344/350.0
SKVPIVVHCSAGIGRTGTIVAIEYILE------KIA--------ENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
   ||.||||||.|||||.|.....|.      ..          .|   ..  .|. || ||   .||  |..||.  .|.||
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 300-361 1.3e-09 32.3 In-house 1-61 (69) alignment 
Range on Protein: 300-361
Range on HMM: 1-61/69.0
IVVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVM
.|||||.| |||||..||   . .|  .|    . . |. .|  |   . |...|.|||  .
mvvhcssgtgrtgtfiaimvemarikseklvd.ifnnvqymrkcrpmmvmneieyifihdal
subfamily_eak_pd Subfamily eak 129-279 2.9e-09 30.8 In-house 50-194 (332) alignment 
Range on Protein: 129-279
Range on HMM: 50-194/332.0
DIAITKNRYQDVPcQDLSAVKLD--QPSPCNYIHANYVGCPMIPeKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKL
  |. .| .. || .|   |.|   |  .  || |  .  . .  ...| .  . .. .  || ||...|   ||.| . ||..  |  .|.|    |.|
leavnrnvvkivp.ydrylvrltssqlnrlGyinaslaefsevG.rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreel

tlKSGCVveNVSGSKPMERDpEIQITMLNLTySGGQTMSVRHLQWTEWPDRGV
  | | .  .|   . ..|.  ..  .| |.  | .|  | | .   | .  .
..kfGil..dverkefvkrn.iletrllels.kGnethrvlhykvfGwtettl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 297-365 7.5e-09 29.4 In-house 265-344 (349) alignment 
Range on Protein: 297-365
Range on HMM: 265-344/349.0
KVPIVVHCSAGIGRTGTIVAIEYILE----------KIA-ENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
  ...|||||| ||||..| ....|.          ||  ...   ..   |  || ||   .||  |. .|.  .|.||
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 301-361 9.7e-09 29.5 In-house 1-60 (69) alignment 
Range on Protein: 301-361
Range on HMM: 1-60/69.0
VVHCSAGIGRTGTIVAIEYILEKIAENKPCPpMPELVKALRDQRAFSIQNDVQYLFIHRVM
|||||.| ||||| .||   . .|  .|    . . |. .|  |   . |. .|.|||  .
vvhcssGtGrtGtfiaimvemarikseklvd.ifnnvqymrkcrpmmvmneneymfihdal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 281-365 1.5e-08 28.6 In-house 256-338 (347) alignment 
Range on Protein: 281-365
Range on HMM: 256-338/347.0
PCKLTSLELLSAIrGSKVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpCPPMPELVKALRDQRAFSIQNDVQYLFIHRVMLNYF
| | .|  |.. . . . |.|| |  |. |. |.|    |.|.. . |  |   .| | .|||||  .   . | .  |  | |.
pvkesstslianl.eklapvvvmcdlgldrsatvvltsiiieqvldgk.tpdcddlfkkmrdqragvftmsifytyairaalfyl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 108-221 2.8e-08 27.7 In-house 76-181 (244) alignment 
Range on Protein: 108-221
Range on HMM: 76-181/244.0
GLAKYTRPDMTqVMFNANQsPDIAiTKNRYQDVPCQDLSAVKLDQPSPCN-YIHANYVGCpMIPEKRFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKt
|  .  ||| . || .| . |. .  |||       |.. | | . |  | || | .||| .     .| .| || .|  .|| |... .|. .|.|   
gsqniirpdps.vmkdafn.pnns.wknregaglpfdfnrvplskgsmgntyinasfvgc.lgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.

VEMGklkcAQYWPAA
||       .||| .
veee....deywpds
0038934 (Phosphotyrosine protein) phosphatases II 271-317 6.8e-08 27.9 In-house 84-135 (194) alignment 
Range on Protein: 271-317
Range on HMM: 84-135/194.0
WTEWPDRGVPPCKLTSLELLSAI-----RGSKVPIVVHCSAGIGRTGTIVAI
   .||.|..|   . |. |...     . ..  ..||| ||.|||||.|| 
klpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
PTEN_1 272-316 7.3e-08 27.4 In-house 100-149 (196) alignment 
Range on Protein: 272-316
Range on HMM: 100-149/196.0
TEWPDRGVPPCKLTSLELLSAIRGS-----KVPIVVHCSAGIGRTGTIVA
 ...| |.|.      .. |.|        .  ..||| ||.||.||.||
fpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_PTPDC1_pd Subfamily PTPDC1 297-359 6.6e-07 23.9 In-house 114-170 (182) alignment 
Range on Protein: 297-359
Range on HMM: 114-170/182.0
KVPIVVHCSAGIGRTGTIVAIEYILEKIAENKpcppmpELVKALRDQRAFSIQNDVQYLFIHR
.  . ||| || |||| ..|   .  |  . .      . .| .|..|. |||   |  ... 
egkvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelvke
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 173-245 1.3e-06 22.0 In-house 237-303 (440) alignment 
Range on Protein: 173-245
Range on HMM: 237-303/440.0
RFICAQGPLDQTIDEFWWMVIQNKVEQIVMLCKtveMGKLKCAQYWPAAQgEKLTLksGCVVENVSGSKPMER
 ||..| ||| |. .|| .| . ..  |.|| .   .    |. |||      .|.  |       ||. |.|
afiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvnt.rsvtf..gpftvghkgsenmnr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 109-205 1.6e-06 21.9 In-house 21-118 (347) alignment 
Range on Protein: 109-205
Range on HMM: 21-118/347.0
LAKYTRPDMTQVMFNANqspdiaITKNRYQDVPCQDLSAVKLDqP---------SPCNYIHANYVGCPMiPEKRFICAQGPLDQTIDEFWWMVIQNKVEQ
||.|. ...| | .. .      ..||| .||  .| . | |  |          . .|| | ..      .| .| .| || .|. .|| ||   || |
lanyspskftsveweks......lsknrskdvklidatrvvls.peksknsraddvetyinashikfdn.askeyiltqyplpdtvrdfwkmvsvtkvtq

IVMLCK
.| . .
vvtife
DSPc Dual specificity phosphatase, catalytic domain 288-323 2e-06 22.7 Pfam-A 64-98 (133) alignment 
Range on Protein: 288-323
Range on HMM: 64-98/133.0
ELLSAIRGSKVPIVVHCSAGIGRTGTIVaIEYILEK
| ..... ..  ..||| ||| |..|.. | |....
efiekaeqkgkkvlVHCqaGisRSatli.iaYlmkt
DSPc Dual specificity phosphatase, catalytic domain 288-323 2e-06 22.7 In-house 64-98 (133) alignment 
Range on Protein: 288-323
Range on HMM: 64-98/133.0
ELLSAIRGSKVPIVVHCSAGIGRTGTIVaIEYILEK
| ..... ..  ..||| ||| |..|.. | |....
efiekaeqkgkkvlVHCqaGisRSatli.iaYlmkt
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 171-374 2.2e-06 20.5 In-house 114-318 (346) alignment 
Range on Protein: 171-374
Range on HMM: 114-318/346.0
EKRFICAQGPL---DQTIDEFWWMVIQNKVEQIVMLCKTVEMGKLKCAQYWPAAQGEKLTLKsgCVVENVSgSKpMERDP-EIQITMLNLTYSGGQTMSV
|...| || |    .  ...||.|. |.... . ..     . .   . .     | . | |   ...|   .  .  || |  | .|    |      |
ehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgk..mfinnrr.ad.vsgdpkeytievlpegnsdsvicqv

RHLqwTEWPDRGVPPCKLTSL----ELLSAIRGSKVPIVVHCSAGIGRTGTIVAIEYILEKIaENKPCPPMPELVKALRDQRAFSIQNDVQYLFIHRVML
 |   . |     ||  |  .    ..||  .  .. . |    | ||. ...   | .... .|   | . |..|....||  ...   ||  |. ...
hhh..apwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainql.nngiepniceimknikqqrpggvesfaqyasiyaivf

NYFLEKYKEKYA
.|   |   | |
dyiarkrggkka
PTPc_motif_SM00404 288-351 5.5e-06 21.3 In-house 71-127 (140) alignment 
Range on Protein: 288-351
Range on HMM: 71-127/140.0
ELLSAIRGSKVPIVVHCSAGIGRTGTIVAIeYILEKiaENKpcpPMPELVKALRDQRaFSIQND
. ..... ..  ..||| ||. |..|...  |....  ..     . | .......|  .|.  
dfienaekkggkvlVHCqaGvSRSatliia.Ylmry..rql...slaeayefvkerR.piispn