Gene F38H4.4 in Caenorhabditis elegans

Synonym: CELE_F38H4.4, F38H4.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf16
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP079_AA protein Get Run
CeleP079_AA_184-458 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 179-481 1.8e-204 671.9 In-house 1-303 (303) alignment
Range on Protein: 179-481
Range on HMM: 1-303/303.0
NTEEKKQKWLGLAKRFVDEDANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSDSSYIHASYLELDTQKRAILTQLPLPHTSADFW
..|||||||..||||..|||||||.|.||.||||.||||.|.||||||.||||.||||||||||.|||||||||||||||..|.||||||||.||.||||
iseekkqkwkllakrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfw

QMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPKFVKQIWQ
||||||.||||||||||||||.||||.|||||||||.|||||||||||||||..|||||||.||||||||||||.|||.|||||.||..|||||||||||
qmiieqkvkcvlllltdseydklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwq

LQSVLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKLAIPKKPNDEKDKE
|||||||||.|||||||||||||||||||||||||||||||||.||||||||.|||||.||.|||.|||.||||||||.||||.||||||||||||||||
lqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkpndekdke

KDK
|||
kdk

0040438 (Phosphotyrosine protein) phosphatases II 187-480 2.8e-58 193.0 In-house 5-299 (317) alignment
Range on Protein: 187-480
Range on HMM: 5-299/317.0
WLGLAKRFVDEDANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQ
.| . ....  |...  . ||.. |..... .  ....|..|||. |....|||.|.||.      |.||.||| .    ... |.|| |||.| .|||.
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS--NGDYKSFLHIHHYNAWPHNNIP--GNGSPKFVKQ
|. ||.|.... | .  |..    .  .|  ...|.... .... ...    ..|..| .. |.  ..... .....|| .||. ..|   .   .|...
mvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldflea

IWQLQSvlrkySPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKLAIPKKPNDEK
... ..     .|..|.. ..  |.||.|||.. ....  |. |. ..|. ......|. | .|.|.. |. |.|..|.|... .. .. | ..|    |
vreale.....dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk

DKEKD
 ....
llipl

0036941 (Phosphotyrosine protein) phosphatases II 213-467 2.3e-55 183.4 In-house 27-287 (297) alignment
Range on Protein: 213-467
Range on HMM: 27-287/297.0
IPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSDSS--YIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR
...| .  ....|..|||. |....||. |.|.|..  ||.|||...   ... |.|| |||.| .|||.|. ||.|.... | .. |..    .  .| 
llgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpl

N-QDFLNFEERSIRVGEFKRVeIMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNNIPGnGSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTF
. ...|.... .... ... | . |...| .. |..  .... .....||  ||....|      ... |.....||... ...|.. ..  |.||.|||
eegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpe.spaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtf

ALFETAHLSLHS--EQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKLAI
.. ....  |..  .. ..|..... ..|. | .|.|.| |. |.| .|.|... . ..  ..
iaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll

0039614 (Phosphotyrosine protein) phosphatases II 200-458 7.8e-53 175.2 In-house 32-290 (297) alignment
Range on Protein: 200-458
Range on HMM: 32-290/297.0
NIAANDFEQVVSYIPPsVTKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLELDT--QKRAILTQLPLPHTSADFWQMIIEQRVKCVL
..  ..||...|..|.  .  ....|..|||. |....||| |.|        ||.||.|||..     ... |.|| |||.| .|||.|. ||.|....
tllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtviv

LLLTDSEYDSlGGDFVFPRNQDflNFEERSIRVGEFKRveiMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVLrkySP
 | .  |..    .  .| ...  .... .... ...     ||... . .|.|...  ... ..|  ||....|   .   .|...... .. |   ..
mLtklvelgr.kcaqywpeegg..tygdftvtllkveh...ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael...pk

STPTVYMSLSGCGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
..|.. ..  |.||.|||..  ...  |..|  ..|. ......|. | .|.|.. |. |.| .|.|...
ggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk

0051299 (Phosphotyrosine protein) phosphatases II 178-457 1.2e-52 174.5 In-house 1-286 (288) alignment
Range on Protein: 178-457
Range on HMM: 1-286/288.0
GNTEEKKQKWLGLAKRFVDEDANIAANDFEQVVSYI-PPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLEL-DTQKRAILTQLP
|.|| . ...| | ....  . .. .. ||...|.. ..... .....|..|||. |....|||.|.||      .|.||.|||... ..... |.|| |
gdteisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

LPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS------NGDYKSFLHIHHYNAWPHNN
||.| .|||.|. ||.|...  | .  |..    .  .|  ...|.... ...  . .    .|.... .. |.       .... . ...|| .||...
lpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

IP--GNGSPKFVKQIWQLQSvlrkySPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
.|   .   .|...... ..     |.. |.| ..  |.||.|||.. ....  |. |  ..|. . ....|. | ...|.. |. ||| .|.|..
vpdspellldflrlvrkala.....sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

DSPc_SM00195 212-456 1.4e-52 174.0 In-house 13-261 (263) alignment
Range on Protein: 212-456
Range on HMM: 13-261/263.0
YIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGD
. | ..|. .. ||..|||. .... ||..|.|..      |.||.|.|....  .|. |.|| |||.| .|||.|..|..||... |  ..| ..   |
tspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

FVFPRN-QDFLNFEERSIRVGEFKRVEimDGWVLKVVSVSNGD--YKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVLrkyspSTPTVYMSLSG
  .|.. ..  .|.. |. . | . ..  | ..|....... .   . ... ..|..||....|   .   ...... . .|       |.|.| ..  |
rywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpivVhCsaG

CGRAGTFALFETAHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
.||.|||.. ...  .|..|.  .|. ......|. |....|.|.|..|.|. ..| 
vgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 212-456 1.4e-52 174.0 In-house 13-261 (263) alignment
Range on Protein: 212-456
Range on HMM: 13-261/263.0
YIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGD
. | ..|. .. ||..|||. .... ||..|.|..      |.||.|.|....  .|. |.|| |||.| .|||.|..|..||... |  ..| ..   |
tspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcd

FVFPRN-QDFLNFEERSIRVGEFKRVEimDGWVLKVVSVSNGD--YKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVLrkyspSTPTVYMSLSG
  .|.. ..  .|.. |. . | . ..  | ..|....... .   . ... ..|..||....|   .   ...... . .|       |.|.| ..  |
rywpeesggketfgkisvklvevekkk..deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.....sgpivVhCsaG

CGRAGTFALFETAHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
.||.|||.. ...  .|..|.  .|. ......|. |....|.|.|..|.|. ..| 
vgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey

0046845 (Phosphotyrosine protein) phosphatases II 205-459 2.1e-52 173.6 In-house 5-276 (284) alignment
Range on Protein: 205-459
Range on HMM: 5-276/284.0
DFEQVVSYIPP---SVTKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLEL------DTQKRAILTQLPLPHTSADFWQMIIEQRVKC
.||...|. ..   |..  ....|..|||. |....|||.|.|       .||.||.|||..       ...|. |.|| |||.| .|||.|. ||.|..
efeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrv

VLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSN---GDYKSFLHIHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRK
.  | .  |..    .. .| ....|.... .... . .    .|.... .....|   ...  .....|| .||....| . .  ... .......|..
IVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvpps.pedlleflrlvrellen

YSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQA--TLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
.... |.| ..  |.||.|||.. ....  |. |.   ..|. ... ..|. | .. |.| |. ||| .|.|... 
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0045450 (Phosphotyrosine protein) phosphatases II 207-459 2.9e-52 173.7 In-house 37-306 (307) alignment
Range on Protein: 207-459
Range on HMM: 37-306/307.0
EQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLELD---------TQKRAILTQLPLPHTSADFWQMIIEQRVKCVL
 .|  ... . .  ....|..|||. |....||. |.|       .||.||.|||  ..          ... |.|| |||.| .|||.|. ||.|....
lsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtviv

LLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS---NGDYKSFLHIHHYNAWPHNNIPG--NGSPKFVKQIWQlqsVLRK
 | .. |...   .  .| ....|....  ... ...    .||... .. |.     ..  .....|| .||. ..|   .   .|......   .|..
mltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk...alee

YSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQAT--LDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
.....|.. ..  |.||.|||..  ..   |..|. .  .|| ......|. | .|.||. |. |.| .|.|..|.
lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk

Y_phosphatase Protein-tyrosine phosphatase 225-455 8e-52 171.4 Pfam-A 1-235 (235) alignment
Range on Protein: 225-455
Range on HMM: 1-235/235.0
NMHKNRFADVICLDHSKVHL----SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP-RNQDFLNFEE
|..|||. |... |...|.|    ..| ||.|.|..  ...|. |.|| ||..| .|||.|.....||.. .| .. | ..   .  .| .....|....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RSIRVGeFKRVEIMDGWVLKVVSVSNGDYKS---FLHIHHYNAWPHNNIPGNgspkfVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFETAH
 ....   |  |......|....... . .|    .. .||..||....| .     .|....|   ..|..   |.|.| ..  |.||.|||.. ... 
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

LSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|..|.  .|........|. |....|.|.|. |.| ...|
eqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 225-455 8e-52 171.4 In-house 1-235 (235) alignment
Range on Protein: 225-455
Range on HMM: 1-235/235.0
NMHKNRFADVICLDHSKVHL----SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP-RNQDFLNFEE
|..|||. |... |...|.|    ..| ||.|.|..  ...|. |.|| ||..| .|||.|.....||.. .| .. | ..   .  .| .....|....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

RSIRVGeFKRVEIMDGWVLKVVSVSNGDYKS---FLHIHHYNAWPHNNIPGNgspkfVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFETAH
 ....   |  |......|....... . .|    .. .||..||....| .     .|....|   ..|..   |.|.| ..  |.||.|||.. ... 
ikvelk.ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpes.....pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

LSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|..|.  .|........|. |....|.|.|. |.| ...|
eqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile

0050432 (Phosphotyrosine protein) phosphatases II 209-458 1.2e-51 171.3 In-house 51-300 (308) alignment
Range on Protein: 209-458
Range on HMM: 51-300/308.0
VVSYI-PPSVTKHQFVKNMHKNRFADVICLDHSKVHLS-DSSYIHASYLEL---DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGG
. |.  ... .  ....|..|||. |....||| |.|. .|.||.|||  .   . ... |.|| |||.| .|||.|. ||.|...  | .  |..    
llsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekc

DFVFPRN--QDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNNIPGNgspkfVKQIWQLQSVLRKYSPSTPTVYMSLSG
.  .| .  ...|...  .... . .    .|.... .. ..|  ...  .... || .||. ..| .     .......   .||. |. |.| ..  |
aqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhytnWpdhgvPps.....peilldflelvrkslpggpivVHCsaG

CGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
.||.|||.. ....  |. |  ..|. ... ..|  | .. |.. |. |.| .|.|...
vGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0043336 (Phosphotyrosine protein) phosphatases II 201-457 4.4e-51 169.4 In-house 21-277 (278) alignment
Range on Protein: 201-457
Range on HMM: 21-277/278.0
IAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLL
.  ..||.. |. ... .  ....|..|||. |....||| |.||.      |.||.|||...   ... |.|| |||.| .|||.|. |..|.... | 
llllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLt

TDSEYDSLGGDFVFPrnQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVS--NGDYKSFLHIHHYNAWPHNNIPGnGSP---KFVKQIWQLQSvlrkySP
.. |... . .  .|  ...|.... .... ...    .|.... .  |.    ... . ...|| .||....|        .|.|.... ..     ..
elvelgrvkcaqYwp..ggsltygdftvtllkeeh...lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpe.slsllldflkavreale.....ds

STPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
..|.. ..  |.||.|||.. ....  |..|. ..|| ......|. | .|.|.. |. |.| .|.|..
ngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl

0045098 (Phosphotyrosine protein) phosphatases II 204-458 5.4e-50 165.7 In-house 12-273 (278) alignment
Range on Protein: 204-458
Range on HMM: 12-273/278.0
NDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHlsdsSYIHASYLELDtQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGG
  ..... .|| ..| .....|..|||. |....||| |.     ||.|||..   .|. |.|| |||.| ||||.|. |....... | .  |..    
efefllllgipseitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

DFVFPRnQDFLNFEERSIRVGEFKRVEIMDGWVLKVVSV---SNGDYKSFLHIHHYNAWPHNNIPGNG----SPKFVKQIWQLQSVLRKY--------SP
.  .|  ...|.... .... ...... .  ..|.|. .    ..... .....||  || ...| .       .....| . ...| ..        ..
aqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

STPTVYMSLSGCGRAGTFALFETAHLSLhseQATLDLVKCLEMVRNGRIH-ACQNLTQFSFVYTLLAEHIL
..|..     |.||.||...  .    |   . ..|| ......|. | . |.||| |. |.| .|.|..|
ggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0047943 (Phosphotyrosine protein) phosphatases II 212-457 2.4e-49 163.6 In-house 24-272 (273) alignment
Range on Protein: 212-457
Range on HMM: 24-272/273.0
YI-PPSVTKHQFVKNMHKNRFADVICLDHSKVHL--SDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVF
.. . . .  ....|..|||. |....||| |.|  ..|.||.|||... ..... |.|| |||.| .|||.|. ||.|...  | .. | .    .  .
lkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYw

PRNQD--FLNFEERSIRVGEFKRveiMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNNIPGnGSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRA
| ...  .|.... .... . .     |.... .. ..|   ... . ...||  || ...|      ... |......|...  ..|.| ..  |.||.
pleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvpp.slesllefielvrkalealpsngpvvVHCsaGvgRt

GTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
|||.. ....  |. |  ..|. ... ..|. | .. |.. |. |.| .|.|..
gtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0040439 (Phosphotyrosine protein) phosphatases II 218-458 2.1e-46 154.0 In-house 4-247 (249) alignment
Range on Protein: 218-458
Range on HMM: 4-247/249.0
TKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRn
.  ....|..|||. |....||| |.||.      |.||.|||...   ..| |.|| |||.| .|||.|. |....... | .. |..  . .  .|  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

QDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSNGDYKSFLHIHHYN--AWPHNNIP--GNGSPKFVKQIWQLQSVLrkySPSTPTVYMSLSGCGRAGTF
...|.... .... ...    .|.... .. ..|  ... ....|..   ||. ..|   .   .|...... .. |   ....|.. ..  |.||.|||
ggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...pkggpvlVHCsaGvgRtGtf

ALFETAHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
..  ...  |. |.  .||  .....|. | .|.||. |. |.| .|.|..|
iaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallelll

0037934 (Phosphotyrosine protein) phosphatases II 220-456 1.1e-45 151.5 In-house 5-241 (243) alignment
Range on Protein: 220-456
Range on HMM: 5-241/243.0
HQFVKNMHKNRFADVICLDHSKVHLSDSSYIHASYLELDtqKRAILTQLPLPHTSAD----FWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPrnQDFlN
.... |..|||. |....||| |.|..|.||.|.. .    .| |.||.|||.| .|    ||.|. |....... | .. |.. .. .  .|  ... .
allpenlsknrysdilpydhsrvklegsdyinanliyvt..prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.t

FEERSIRvgeFKRVEIMDGWVLKVVSVSN---GDYKSFLHIHHYNAWPHNNIPG--NGSPKFVKQIWQLQSV---LRKYSPSTPTVYMSLSGCGRAGTFA
... ...   .. .| .|.... .....|   .|.. . . .|| .||....|   .   .|...... ..    |...... |.. .   |.||.||..
ygdftvt...llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtli

LFETAHLSLhseqaTLDLVKCLEMVRNGRIH-ACQNLTQFSFVYTLLAEH
.  . .| |     ..|| ......|. | . |.|.. |. |.| .|.|.
aaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel

0042113 (Phosphotyrosine protein) phosphatases II 220-455 1.2e-44 147.9 In-house 4-241 (245) alignment
Range on Protein: 220-455
Range on HMM: 4-241/245.0
HQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnQD
 ....|..|||. |....||. |.||      ||.||.|||  ..   .. |.|| |||.| .|||.|. |....... | .. |..  . .  .|  ..
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.ge

FLNFEERSIRVGEFKRveiMDGWVLKVVSVS--NGDYKSFLHIHHYNAWPHNNIP--GNGSPKFVKQIWQLQSVlrkySPSTPTVYMSLSGCGRAGTFAL
.|.... .... ...    .|.... ...|.    |.. . . .||  ||....|   .   .|.. ... ..     ....|.. ..  |.||.|||..
sltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae....dsngpvlVHCsaGvgRtGtfia

FETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
  ...  |..|. ...| ......|. | .|.|.. |. |.| .|.|
aylmleqlekel.gvsleeavkelrsqRpgavqtpsqyrflyealle

subfamily_PTPRD_pd Subfamily PTPRD 206-457 6.6e-33 109.2 In-house 29-281 (564) alignment
Range on Protein: 206-457
Range on HMM: 29-281/564.0
FEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEY
.... .    .... .   | .|||.|...  ||| | |      ..| || ||...  ...|  | || ||..| .|||.|. ||..... .|   .| 
ykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEk

DSLGGDFVFPRNQdFLNFEERSIRVGEFKRVEIMDGWVLKVvSVSNGDYKSFLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSvlrkySPSTPTVYMS
.    .  .| ..   ...|  . . | .... .    .|. . .. . .   .  |. .||....| .. .  ...... .|..     . . |.|   
gkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.....pdagPivVhC

LSGCGRAGTFALFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
 .| || |||   .   |    |..|.|. ......|. | .  |. .|..|... ..| .
SaGVGRTGtfividam.lerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileal

subfamily_PTPN12_pd Subfamily PTPN12 222-456 1.7e-32 107.4 In-house 37-276 (290) alignment
Range on Protein: 222-456
Range on HMM: 37-276/290.0
FVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDF-
  .|..|||. |..  |.|.|.||      .|.|| |....  . ... | .| |||.|  |||.||.|..|. |...    | .    .  .| ...  
keenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeee

LNFEERSIRVGEFKRveIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRkySPSTPTVYMSLSGCGRAGTFALFETAH
|.|.| .. . | |.  . |..... . | . . .  ..  ||.|||  ..| .   . .. |...... .  | ..| |    .|.||.||    . ..
lefgefevtleeeka..vdddflirtLkveaqkesrkvyqfhYtaWPDhgvPss.aksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvr

LSLHSEQA--TLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
  |..|.   .||. . .  .|. |  . |   |...||  .|| 
ellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 223-456 3e-32 107.0 In-house 54-289 (298) alignment
Range on Protein: 223-456
Range on HMM: 54-289/298.0
VKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDfLN
 .| .|||.||.| ||.|.| |..      | || ||.|.  ...   |.|| ||..| .|||.|..|. .... .| .  | | .     .| ..   .
penkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.et

FEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHyNAWPHNNIPGNGSPkFVKQIWQLQSvLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLS
..| .... . ..   .    ||| . .. . ..  ..|.   || . .| | .   .. . . .   .. .  .| .    .| ||.|||   ..    
ygeitvsllskeefadlivrklkvskkkeekerevrqlhf.tsWpdkgvpenats.vldllrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvler

LHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
.. || ..|. . ....|. |..| |  .|..|.|..  | 
vkkeq.vvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_PTPN1_pd Subfamily PTPN1 217-455 3.8e-32 106.2 In-house 24-269 (290) alignment
Range on Protein: 217-455
Range on HMM: 24-269/290.0
VTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQD-
... .. .|  .||. ||   |||...|   |  || || .||.  ... |||| |||.| . ||||. ||. |.|..|    | ...     .|.... 
treaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

-FLNFEERSIRVgEFKRVEIMDGWVLKVVSVSN---GDYKSFLHiHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFAL
  | .|. ...| .. . |. . ...... . |    . .. || .|| .||   .|     .|.| ......     |   |.|    .| ||.|||.|
kellledtklkv.kliseerksyytvrllelenlktqetreilh.fhyttwpdfgvpes.paaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

FETAHLSLHSEQA--TLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|  . .. ..   ..|. | |  .|. |.   |   |. | |. . |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRB_pd Subfamily PTPRB 216-455 1e-31 105.1 In-house 42-283 (293) alignment
Range on Protein: 216-455
Range on HMM: 42-283/293.0
SVTKHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP
.|.. .  .|  |||. ...  |||.|.|      |.| || |.|..  . ..  | || |||.|  |||.|. |.... ...|    |      .  .|
avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWP

RNQDFLNFEErsIRVgEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFAL
....  .. .  |.| ...  | .. ||.. ....... .  .. .|. .||  ..| . . .... . .......| . ..|.|    .| ||.|||  
adeepvlyGd..ikv.tlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektk.tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfia

FETAHLSLHSeQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 ..   .... . ..|..  .  .|. | .  |. .|. |... . .
ldrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvld

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 180-459 1.3e-31 104.1 In-house 3-287 (302) alignment
Range on Protein: 180-459
Range on HMM: 3-287/302.0
TEEKKQKWLGL--AKRFVDE-DANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELD-TQKRAILTQLPLPHT
.||.|.|| .   ||..|.. |.    ..|... .   .    . | ||..||.  || .||.  | |.    ||..|| .|.   ..  ||.|||   .
veeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvds

S---ADFWQMIIEQRVKCVLLLLTDSEYDSlGGDFVFP-RNQDFLNFEErsIRVGEfKRVEIMDGWV--LKVVSVSNGDYKS-FLHIHHYNAWPHNNIPg
.   ..||.|. ..... | .|. . | .    . .|| . .|......  ..|   ..|| ... .  . .  . .|   | .  . . . |.....| 
edsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygk..mfvNn.rkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvp.

NGSPKFVKQIWQLqsVLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
    . .|.. ..    .| . . .|| .|  |.||||.|    .|  .|... .       .. .|. | .| ..|.|. ..|  |. .|. 
vkyaeliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikk

subfamily_PTPN3_pd Subfamily PTPN3 217-450 3.6e-31 103.1 In-house 33-268 (280) alignment
Range on Protein: 217-450
Range on HMM: 33-268/280.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSDSS--YIHASYLELDTQK-----RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR
... .  .|..|||. |..  |. .|.|..|.  || |.|.... .      | | || ||..|..|||||. ||... ...| |  |         .|.
isaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe

NQDFLNFEERSIRVGEFkrvEIMDGWVLKVVSVSNGDYKSFLHIHH--YNAWPHNNIPGNgSPKFVKQIWQLQSVlrKYSPSTPTVYMSLSGCGRAGTFA
..| |.. | |... .    .    .||. . ... . |   .|..  | ||| ...| . | .|.. . .....  . . ..|.|    .| ||.| . 
tedeleygefsvkceke...detksyvlrelvlkdketkeerkilqlqylaWpdhgvPdd.sadflefvervrkl..rsgkeePvvvhCsaGigrtGvli

LFETAHLsLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVY
|.|||   |  ..  .  .. . ..|. |    |. .|. || 
lletala.lieaaepvypldivrtmrdqramlvqtasqykfvC

subfamily_PTPN9_pd Subfamily PTPN9 220-457 1.2e-30 101.6 In-house 37-290 (297) alignment
Range on Protein: 220-457
Range on HMM: 37-290/297.0
HQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP-RNQ
 .   |..|||..||.|.|...|.|.       | ||.|....   ||.| | || ||..|. |||.|. ||.|  ...     |   |     .|  ..
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

DFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHiHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVLRK-------YSPSTP-TVYMSLSGCG
.  .| . |... | .  |     ||..  | ... ..  | . . .||   .| ...   ...... . |... |       . || |  |    .| |
ssaefgdlsvsnveveeeedykvrvleiknvkteesrkvth.fqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RAGTFALFETAHLSLhSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
|.|||. .. .   |  |..|.|.|......|. | .. |   |. | |  . |. 
rtGtfitldiclsrl.eevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_PTPN13_pd Subfamily PTPN13 219-453 1.6e-30 101.3 In-house 31-265 (273) alignment
Range on Protein: 219-453
Range on HMM: 31-265/273.0
KHQFVKNMHKNRFADVICLDHSKVHLSDSS-YIHASYLELDTQK---RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFL
. .  .|..|||. .|.  |...|.|.|.. || ||....  .|   ..|..| |||.| .|||||. ||... . .. .. | . .  .  .| ...  
vgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

NFEERSIRVGEFkRVEIMDGWVLKVVSVSNGDYKSFLHIHHYN--AWPHNNIPGNgSPKFVKQIWQLQSVLRkysPSTPTVYMSLSGCGRAGTFALFETA
   .  ..|    .|. .||.|.. . |.. . .   .. | |  .||  ..| . . .... . ..... .    ..| |    .| ||.||.   ...
lkvsnrlevell.kvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPss.aaellqfvaevrrlqt...dagPivvhcsaGiGrsGtlitidvv

hLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLL
 | | . .  .|. . .. .|. |    |   |. |||  .
.lglierdkefdvkeivrklreqrqgvvqtkdqyifvykai

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 223-456 2.3e-30 100.6 In-house 7-241 (250) alignment
Range on Protein: 223-456
Range on HMM: 7-241/250.0
VKNMHKNRFADVICLDHSKVHLSDSS------YIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLgGDFVFPRNQDFln
 .| .|||.||.| ||.|.| |  ..      || ||.|.  .. |  | || ||..|  |||.|..|. .. ...| . .| .       .| ..    
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae..

fEERSIRVGEFKRVEIMDG--WVLKVVSVSNGDYKSFLHIHhYNAWPHNNIPGNGspKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALFETAH
 .  ...|  ... |  |    .||. . .. | .   ..| . .||   .| .   . | .. .     .... ..| .    .| ||.|.|   ..  
.kyGdvtvsllskeefadytkrklklskakkaderivrqlh.fvvWPdkgvPeva..tavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

LSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
  |. |. ..|. | ....|. |.|| . |.|..|||... . 
erlkkek.vvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 205-458 6.1e-30 99.4 In-house 25-281 (318) alignment
Range on Protein: 205-458
Range on HMM: 25-281/318.0
DFEQVVSyIPPSVTKH--QFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTD
..|..    . .||..      | .|||.|...  ||..|.|.      .| || |.|..  ..|.| | .| |||.|  |||.|. ||  . ...|   
eyerlsr.seetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe

SEYDSLGGDFVFPRNQDfLNFEErsIRVGEFKRVEiMDGWVLKVVSVSNGDYKSF--LHIHHYNAWPHNNIPGNGsPKFVKQIWQLQSVLRKYSpSTPTV
.|      .  .| ..   ....  ..|   ..|| .. .||. ..|.. . ..    . .|| .|| ...| .|  .... . | ... .| .  .|.|
eergkakvhryWPskgs.rsygk..lvvelkeeve.lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaqqksg.agpiv

YMSLSGCGRAGTFALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
    .| ||.|.|   ..    .. ..|..|. .  ...|. |    |   |. |.|. | | . 
vhCsaGvGrtGvfiavdillerik.aealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_PTPN23_pd Subfamily PTPN23 225-455 1.2e-29 98.1 In-house 43-278 (288) alignment
Range on Protein: 225-455
Range on HMM: 43-278/288.0
NMHKNRFADVICLDHSKVHLSDS--SYIHASYLELDT--QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQD-FLNFEER
. .|||. |..  ||..|.| .|   || ||...  .      | || ||. |..|||.|. ||... . .||. .| .    |  .| ...   .|.. 
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdl

SIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIhHYNAWPHNNIPGNGS--PKFVKQIWQ-LQSVlrKYSPSTPTVYMSLSGCGRAGTFALFETAHLSL
|. . . .. | .   |||.   ..   ||  |. ....||.  .|   .   .|.... . ...|  .    || |   ..| ||.|.|||  .|   |
svtlksvretethvervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeav..qrksktPlvvhCsaGvgRtgvfalvyaavrel

HSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
. ..  ||... .. .|. | .  |. .|. |.|    |
ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle

subfamily_PTPRA_pd Subfamily PTPRA 197-458 7e-28 92.5 In-house 29-296 (330) alignment
Range on Protein: 197-458
Range on HMM: 29-296/330.0
EDANIAANDFEQVVS-YIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKR-AILTQLPLPHTSADFWQMIIEQRVKC
.|..   ..|. . .  |  ..   .  .|..|||. ...  |.|.|.||      .| || ||...   .|   | .| |. .|  |||.|| ||.   
ddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksat

VLLLLTDSEYDSLGGDFVFPrNQDFLNFEERSIRVGEFKRVE---IMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRK
...|    | .       .| ..  . . .  . | . . ..   . .  | ..   .. . .  ..  |...||.  .| ..    .| . ..... ..
ivmltelkerkeekcaqywP.deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiG.mlkllkkvkklnqq

YSPsTPTVYMSlSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
..  . .|. | .| ||.|||  ...    ...|.  .|. . .. .|. | .  | . |. |.|  | |. |
sag.pivvhcs.aGvGrtGtfivldavlervkaer.kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 221-457 7.7e-28 92.4 In-house 37-276 (281) alignment
Range on Protein: 221-457
Range on HMM: 37-276/281.0
QFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDF
.  .|..|||. ...  |...|..      ... || |.... .. .|. | || |.|.. ..||||..||.|. . ..  . | . |     .| ..  
kadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnse

LNFEERSIRVGEFKRVEIMDGWVLKVvSVSNGDYKSFLHIhHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSPsTPTVYMSLSGCGRAGTFALFETAH
|.. .  ..  . .. . .   ..|. . ..|. ..  .. .| ||| . .| . . ....   ..... .| .  .| |    .| ||.||.  .... 
lkygdvtvkstaeeekatyierkfkl.eresgetreveql.aytaWPdhGvPattk.ellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlv

LSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
 ....|...||.   .. .|. |    | ..|..|||  . . .
kaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 217-460 8.8e-28 92.2 In-house 39-282 (288) alignment
Range on Protein: 217-460
Range on HMM: 39-282/288.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR
||. .  .| .|||. ... .|. .|.| .      . || |||.. . .| . | || ||..|  |||... |.... .. |    | .    .  .| 
vtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd

NQDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFALF
...  |. .  . . | |    .. .||. . .     .  .. ..| ||| ...| .  | ... . |..    .   . | .     | ||.|||   
adkpknyGsvtvtlveske...ledfvlrklllekkkteleitqyqylaWpdhgvPeskap.llellrqvkvanqad..tgpiivhCsaGvGrtgtFial

ETAHLSLHSeQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
...   ... . ..|..  .. .|. |    |.|.|. |.|  |.. | ..
dalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 194-480 1.1e-27 92.2 In-house 28-313 (319) alignment
Range on Protein: 194-480
Range on HMM: 28-313/319.0
FVDEDANIAANDFEQVVSYIPPsVTKHQ---FVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIE
 .|.| ..   .| ..    ..  .. .     .|  |||. ...  |...| |        | || ||...    ... | .| ||. | ||||.|| |
dfdddltklevefrracklgvn.ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwe

QRVKCVLLLLtdseyDSLGGDfVFPRNQDfLNFEERSIRVgefKRVEIMDGWVLKVVSVSN-GDYKSFLHI--HHYNAWPHNNIPGNGSPkFVKQIWQLQ
...  ..||           .  .| . .  . |.  ..|   . ||  . .|.. . .|. |  |   .|  .|.  ||.   |  .|. ... . ...
yncstivllt.....kdkcsq.ywplkiv.ikeerfkvkv...dsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsd.lmrlvkkvr

SVLRKYSPSTPTVYMSLSGCGRAGTFALFEtAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE-HILdnGFCKLAIPKKPNDEKDKEK
 . .|    .. |    .|.||.|..  .. . |.   |.  .|. . .. .|. | .  |.|.|. |.|. | | |..  |.. .|.|  |   ... .
hltskenhranivvhcsaGvGrtGvyivld.vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf..ghsdvampdfpayleelsn

D
.
k

subfamily_PTPN14_pd Subfamily PTPN14 220-457 1.1e-27 91.8 In-house 44-296 (300) alignment
Range on Protein: 220-457
Range on HMM: 44-296/300.0
HQFVKNMHKNRFADVICLDHSKVHLSD-----SSYIHASYLELD---TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRN-
 .  .| .|||| ||.  ....|.||      . || || ..     ...  | .| ||..|  |||||. || |. ...|  . |         ||.. 
aklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

--QDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIhHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRKYSPST-------PTVYMSLSGCG
  .. ..|..  .     .  . .    ||.  .  ..... .|.  |. || ...| .   .|.. . ..||| || . ..       | .   . | |
skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhl.qytDWpdhgvPeD.vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RAGTFALFETAHLSLHSEqATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
|.|   | .    .|. .  ..|. | |...|. | .  |.|.|. |||..| ...
rtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 202-457 2.5e-27 90.8 In-house 25-283 (319) alignment
Range on Protein: 202-457
Range on HMM: 25-283/319.0
AANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLT
 ...|...    . .... .  .| .|||. ...  |...| ||      .| || ||...   .... | || || .|  |||.|. |... .|..|  
lekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

DSEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRVEIMDGWVLKVvSVSNGDY-KSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSpSTPTV
..|   .    ..|. ..| .. .  . . | .. | .    ||.    ...     .  ..|..|| ...| ..    .. . ...   .| . | | |
lveklkvklkkywpe.enfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekat.slldllkrirksrektq.sgPiv

YMSLSGCGRAGTFALFEtAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
     | || |||   . | |   .|...||. .   ..|  |    |.  |..|.|  | | .
vhCsaGvGRtGtfivld.amlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 222-485 3e-27 90.8 In-house 22-282 (284) alignment
Range on Protein: 222-485
Range on HMM: 22-282/284.0
FVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLtdseyDSLGGDfVFPRNQDfL
  .|  |||. ...  |...| |        | || ||...    ... | || ||. | ||||.|| |...  ..||      .    .  .| . .  
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsq.ywplkiv.i

NFEERSIRVgefKRVEIMDGWVLKVVSVSN-GDYKSFLHI--HHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALFEt
. |.  ..|   . ||  . .|.. . .|. |  |   .|  .|.  ||.   |  .|. ... . ... . .|    .. |    .|.||.|..  .. 
keerfkvkv...dsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsd.lmrlvkkvrhltskenhranivvhcsagvgrtgvyivld.

AHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE-HILdnGFCKLAIPKKPNDEKDKEKDKENED
. |.   |.  .|. . .. .|. | .  |.|.|. |.|. | | |..  |.. .|.|  |   ... .... .|
vlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf..ghsdvalpdfpayleelsnksdfdd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 217-460 4.3e-27 90.0 In-house 45-287 (297) alignment
Range on Protein: 217-460
Range on HMM: 45-287/297.0
VTKHQFvkNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELdTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFprN
|....   |..|.|.....  | |.|.|       || |. ||...   ..| | || | . | ||||.|.....|. ...|  |.| |     . .  .
vaekkv..nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkg.nkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWs..d

QDFLNFEERSIRVgefKRVEIMDGWVLKVVSVSNGD--YKSFLHIHHYNAWPHNNIPG-NGSPKFVKQIWQLQSVLRKYSPStPTVYMSLSGCGRAGTFA
.   .| . |. .   . |.   | . . ..|..|.   . ... ...  ||.....  .  ....| | ... .  . . . | .   |.| ||.| . 
kgvttfGdvsvvl...lsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg.PllvhclaGvGrtgvll

LFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
  .   ..   .. ..|. . ....|. | .  |   |..||| .. | .| .
tidsv.vaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 206-462 6.5e-27 89.2 In-house 16-275 (285) alignment
Range on Protein: 206-462
Range on HMM: 16-275/285.0
FEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELDT--QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSL
 ...  |.|| .|   .  |   ||.||| |.. ..| |   |  |||||.. .    |   | || ||| | .|||.|| ....  ||.| |  |    
qdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggve

GGDFVFPRN-QDFLNFEERSIRVGEFKRvEIMDGWVLKVVSVSNGDYKS--FLHIHHYN--AWPHNNIPGNGSPkfvkqIWQLQSVLRKYSPS-TPTVYM
   . .| .  . ..| .  | . | |  | . | .|. ..| | .  |   |.. | .   || .  | .  |     . .|   ..|  |  .| .  
kcalyypeklgevvkfgkyeitltecke.eaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarp.....mielykwvkkvnpkekpicvh

SLSGCGRAGTFALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGF
  .| ||. ||   . | . .  |.  ....  .  .|  |..| |.  || |.| .| |... .| 
csagvgrtatfvgidyatirim.enpniemldivremramrfqavqshmqflflyvvlmeyfigegv

subfamily_PTPRG_pd Subfamily PTPRG 204-458 1.2e-26 88.1 In-house 23-288 (563) alignment
Range on Protein: 204-458
Range on HMM: 23-288/563.0
NDFEQVVSYIPPS---VTKHQFVKNMHKNRFADVICLDHSKVHLSD-----SS--YIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLlL
..||...| . ..   ... |  .| .|||  ...  |.|.|.||.     ..  || |.|..    .|  | || ||..|  |||.|| ||.|. .  .
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiiv.m

LTD-SEYDSLGGDFVFPRnQDFLNFEERSIRVGEFKRVEIMDG--WVLKVVSVSNG---DYKSFLHIHHYNAWPHNNIPGNGSPKFVkqIWQLQSVLrKY
.|.  |      |  .|. .. ..... ...  | ... .      |.| . . ..   |..     .||  ||  . |    |.      . .|   . 
itnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLi..fvkkssaa.nk

SPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
.   |.|    .| ||.||.  ..| .  ...|. . .. . | ..|  | .  |.  |. |..  | | |.
aeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaia

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 201-461 3e-25 83.5 In-house 29-283 (290) alignment
Range on Protein: 201-461
Range on HMM: 29-283/290.0
IAANDFEQVVSYIPPSV-TKHQFVKNM--HKNRFADVICLDHSKVHLSDS---SYIHASYLElDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLT
.| . .|... |.|     .. | ||   .|||. ||.| | ..| |.|     |.|| |..  ..   |||| .|  |  |.|.|.....|  . .|  
lakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk.GlkamfiltqGalkdtvidiwrmvlqekvaaivmlce

DSEYDSLGGDFVFPRN-QDFLNFEERSIRVGEFKRV-EIMDGWVLKVVSVSNGDYKSFLHIhHYNAWPHNNIPGNGspkfvKQIWQLQSVLRKYspSTPT
  |      .  .| .  . | | | ..   | .   . .   .| |  . .|  . . |. .  .|| . ..          . ..  .|||   | | 
liedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhl.kikswpdksvalst.....lallrtlrilrka..sGpv

VYMSLSGCGRAGTFALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQfsfvYTLLAEHILDNG
|    .| ||.|||.  |..   |  .   |||..    .|| |. . |  .|    | .| | .|| |
vvhcsaGiGrtGtfvaievglqill.dGkeldlldlvralrnsrlnsvqvdiq....ylalveilldlG

0049772 (Phosphotyrosine protein) phosphatases II 215-456 7e-25 83.8 In-house 36-279 (314) alignment
Range on Protein: 215-456
Range on HMM: 36-279/314.0
PSVTKHQFVKNMHKNRFADVICLDhSKVHL-----SDSSYIHASYLelDTQKRAILTQLPLPHTSADF----------WQMIIEQRVKCVLLL-------
 .... ....|..|||. |... | . |.|     |.|.||.|||.  |. .. | || ||..|  ||          |.|....  ..  .        
ltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyv..dgflkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

----------------LTDSEYDslggDFVFPRNQDFLNfeersirvgefkrveimdgwvlkvvSVS--NGDYKSF-LHIHHYnawphnNIPGNGSPkFV
                |. ...     ..  ......|.                         ..   . ...   .. ...      ..|... |   
adelsrLdaAlgKtpllildgng....neptaadlellk.........................eelydpelferlgikylri......pvpDgsap.ll

KQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALfeTAHLSLHSeqaTLDLVKCLEMVRNGRI-----HACQNLTQFSFVYTLLAEH
......  ....... .|..    .|.||.|||..  .| | ..     ..| ..||.||. |      .. ..| |. |..  | |.
edfdeflefieeadkggpvlvHCkaGkgRtgtfvv..aaylmkll...gvsleealedvrlkRpinpnpgfieqleqyefilealley

subfamily_PTPN6_pd Subfamily PTPN6 221-457 1.5e-24 81.5 In-house 50-297 (306) alignment
Range on Protein: 221-457
Range on HMM: 50-297/306.0
QFVKNMHKNRFADVICLDHSKVHL-----SDSSYIHASYLE---LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQD
. ..|..|||.  ..  ||..| |     ..| || |.|..    ...|. | ||  |..| .|||.|. ..  . .... .. |         .| ...
akpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeee

FLNfeERSIRVGEFKRvEIMDGWVLKVVSVS---NGDYKSFLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVLRKYsPSTPTVYMSLSGCGRAGTFA
  .    .|.| . .  . .. ..|. .|||   ... .  .. .|...|| ...| . .   .|.... . |. |..   . |.|    .| || ||| 
kee..yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea.eagpivvhCsaGiGRtGtfi

LFETA--HLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
. ..    .. .  .| .|. |. ..||. |    |  .|. |||. ....|
viDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

0041856 (Phosphotyrosine protein) phosphatases II 225-459 2.1e-24 81.5 In-house 1-173 (182) alignment
Range on Protein: 225-459
Range on HMM: 1-173/182.0
NMHKNRFADVICLDHSKvhlsDSSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLtDSEYDSlggdfvfprnqdflnfeersirv
|..|||. |... |||     |..||.|...  .    | |.|| ||..| |||..|. |....... |  .  |.                        
nldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywp.......................

gefkrveimdgwvlkvvsvsnGDYKSFLHIHHYNAWPHNNIPGngSPKFVKQIWQLQSvlrkysPSTPTVYMSLSGCGRAGTFALFEtahL---Slhseq
                      ...   . ..|  || ...|    ..... | . ..      .. |..     |.||.||...     |         
.....................ellerlgiqylylpwpDhgvpd..ldelldfieevle......eggpvlVHCsaGvgRtgtlvaay...lmkkl.....

aTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
  ..| .....||. | ...... |. |.. .| |..| 
.gvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 219-456 5.3e-24 79.7 In-house 43-278 (315) alignment
Range on Protein: 219-456
Range on HMM: 43-278/315.0
KHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLELDTQKR-AILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNq
  . ..| .|||. ..|  |.|.|.|      ..| |. |....  ..||  | .| |.. .  |||... |. .  ...|    | .    .  .| . 
vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.

dFLNFEErsIRVGeFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQsVLRKYSPsTPTVYMSLSGCGRAGTFALFET
  . . .  | |   |  |. . .  . .||  ||    .   || .||  ..|    | ... | . . . .. |  .. |    .| ||.|||  ...
.kviyGk..itvt.rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytip.lmnlirtvk.qhhtnsv.gaivvhcsaGvGrtGtfitlda

AHLSLHSEQAtLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
    .. |.| .|. . .. ||. ||.. | . |. |.|  | | 
vldqaeaena.idvynfitgvrqnrikmvqvaeqyqfiydallet

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 200-458 7e-24 79.5 In-house 23-289 (325) alignment
Range on Protein: 200-458
Range on HMM: 23-289/325.0
NIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRAI-LTQLPLPHTSADFWQMIIEQRvKCVLLL
.  |..|. . |  . . .     .|. |||| .|. ||.|.| |       .| || ||||. | .|     .| ||..|  |.|..... |   |...
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvv

LTDSEYDSLGGDFVFPRN-QDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSfLHIHHYNAWP---HNNIPGNGSpKFVKQIWQLQSVLRK-YS
|   . .       .|..  .  .|    ...   . .      ||.|  |..|. .| ..  .. .|.    .. |      ... . ...  ..    
lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrs.vkqfqlqswddmGvqkrpatli.silqlvkavservtantk

PSTPTVYMSLSGCGRAGTFALFETAHLSLhSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 ||| .    .| ||.|.|. . .|   .  |.. .|. . .. .|. |    .   |....|. |.| ..
astpilvhcsaGvGrtGvfislysalakv.ieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym

subfamily_PTPRK_pd Subfamily PTPRK 224-458 1.8e-23 77.9 In-house 42-278 (314) alignment
Range on Protein: 224-458
Range on HMM: 42-278/314.0
KNMHKNRFADVICLDHSKVHLS----D--SSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFlnF
.| .|||. |..  |.|.| |     |  | || |....  .. .| | || ||..| .|||... ...  ....|    |   .     .| . .   .
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev..y

EerSIRVgEFKRVEIMDGWVLKVVSVSN--GDYKS--FLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKysPSTPTVYMSLSGCGRAGTFALFETA
.   |.| |. ..|.    | .. .|..    ..    ..  .. .||. ..| .    ..| . ....   .     ..|   ..|.||.|||   .. 
g..dikv.elvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsat.gllklvrrvkksqee..eaGrivvhCsaGaGrtGtfiaidiv

hLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 | .  .. ..|. ..   .|. ..   .   |. |.|  . |  |
.ldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 221-457 2.9e-23 77.2 In-house 16-264 (270) alignment
Range on Protein: 221-457
Range on HMM: 16-264/270.0
QFVKNMHKNRFADVICLDHSKVHLSD------SSYIHASYLE--LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQ-
..... . ||.||..   ...| |..      . || | |..   . .|. | .. ||| |  .||.||.|..|......    |      .  .| .. 
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

DFLNFEERSIRVGEFKRvEIMDGWVLKVVSVS-NGDYKSFLHiHHYNAWPHNNIPGNGS-----PKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGT
. ...|.  |.|   .  | ..|..|. . .  .|. .  .| ..||.|| . .| .        . .| . ... . .. . ..|..     | ||.||
ekvkledgkikvlalse.ekeegyiltrlrleekgeerrlvH.fwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

FALFETAHLSLHsEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
. . ..|   |. |.  .|... .| .|. |.   |   |. |.|  ..|..
lialDiavrlLe.etkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 221-458 3e-23 77.2 In-house 40-278 (315) alignment
Range on Protein: 221-458
Range on HMM: 40-278/315.0
QFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPR-NQD
.   |..|||. ... ||...| |       || || |||.. .|..|  | .| ||. .  |||.|.....|  . ..   .| | .     .|  . |
retinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkad

FLNFEERSIRVgeFKRVEIMDGWVLKVvSVSNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFALFETA
  .| . .. .  ..     || . |.  . ... .  .  .... ||.. .. . |  ..| | ....  .|.    . .   ..| ||.| .   .  
svefGsikvel..lsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqts.sllklikevkadngkk..efsllvhcsaGvGrtGvvisidev

hLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 ..   .. ..|. . ....|. |..  |   ...|.|  . |..|
.vaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll

subfamily_CG7180_pd Subfamily CG7180 223-460 3.9e-23 76.5 In-house 40-293 (296) alignment
Range on Protein: 223-460
Range on HMM: 40-293/296.0
VKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNqdFLN
 .|. |||  .|.  |. .| |      ..| || |.| .  ..|.. | |. |  .|  .||... .. ...|  |    ..  .  ... ..     .
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keq

FEERSIRVGEFKRVEIMDGWVLKVVSV--SNGDY-------KSFLHIHHYNAWPH-NNIPGNGSpKFVKQIWQLQSVLRKY---SPSTPTVYMSLSGCGR
. |  . . | |    .  . .|..    . ..        .  ..  ..  |.  ...|   .  ... . . ... .|        |.| .|  | .|
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstn.alielrrrvrlwrekvdedpeegPvvvvssdGasR

AGTFALFEtAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
.| .   . | | | ...  .|. . . ..|. | .  .| ... ..| .| |..| |
sGvylaid.anlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 193-459 8.1e-23 75.9 In-house 9-279 (307) alignment
Range on Protein: 193-459
Range on HMM: 9-279/307.0
RFVDEDANIAANDFEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS----DSSYIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVK
| .|   .   ..|...  . | .|| . |  | .|||. || | |.... .      | |||| || . .. |. | .| ||  |  .|| |.|...|.
rtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekve

CVLLLLTDSEYDSLGGDFVFPRNQDF-LNFEE--RSIRVGEFKRVEI-MDGWVLKVVSVSNGDYKSFLHIHHYNaWphNNIPGNGSPKFVKQIWQLQSVL
.|..|    |   .  .  .| ..   | | |  ..| | ..   ..  |  ...| ..     .    |.|.. |  .| | .| |.       | .  
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlq.w..enwpdrgvpqinltainlleav

RKysPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILD
|      | |    .| ||.||          . . .   |. | .| .|. | .| |.  |. ... .| |. |.
ry..dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 205-457 9.3e-23 75.8 In-house 27-283 (305) alignment
Range on Protein: 205-457
Range on HMM: 27-283/305.0
DFEQVVSYiPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSE
.......  . |.  ..  .| .|||..... ||.....|.      || || |||..    .|. |..| ||..| ||||..|.| .|. ...|    |
qykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklve

YDSLGGDFVFPRNQDF-LNFEERSIRVGEFKRveiMDGWVLKVVSVSN--GDYKSF-LHIHHYNAWPHnnipgNGSPKFVKQIWQL-QSVLRKYSPS--T
 .       .| ..    .|.| |. . ..|    . ... . ...|.  .| .|  .  ..   ||      .| |.|   . .| . | .... .  .
ggkdkCrqYWpesktekkefgefsvelksekt...asdyieRklkisiededkesrtvlqyqltdWPd.....hGvpqfatsllslikrvqkdqkkdkgv

PTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
| .     | ||.|.|   . |   |. |. ..|. . |  .|. |. . |.| |. |..  |.| |
pllVhCsagvgRtGvfiavdialerlkkEe.vvdvfevlkqlRskrmkmvqtldqYvflhdaldeli

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 218-456 1.1e-22 75.5 In-house 21-267 (274) alignment
Range on Protein: 218-456
Range on HMM: 21-267/274.0
TKHQFVKNMHKNRFADVICLDHSKVHL-------SDSSYIHASYLEL-DT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFP
 ...  .. .|||. ...  ..|.| |       .||||| | |.   |. .|  . || |||.| ||||.|| ...|. ...|   .| .       ||
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

RNQDF-LNFEERSIRVGEFKrVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRK-YSPSTPTVYMSLSGCGRAGTF
 ..|. .. .   . .   | .   ... .. .....   .  .. . | .|| .. | . . .... . . ..  ..   . .|.|    .| ||.| |
daedyeiserygdveikvek.iverndysvrklvlkylerersvkhywytdWPdhksPddan.tlldlvleveesreeenaklapvvvhCsaGiGrtGcf

ALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
   . |   |. |. ..|..|    .|  |    |.  |. ...  |...
iaisiavrqlreei.vvdvlkivcnlrldrGGmvqtseqyelihralcly

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 223-463 2.3e-22 74.1 In-house 46-293 (305) alignment
Range on Protein: 223-463
Range on HMM: 46-293/305.0
VKNMHKNRFADVICLDHSKVHLSDS---SYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSL-GGDFVFPRNQDFLNFE
 .. .|||. || |||. .|.|  .    |||| |.   |  || | || || .| |||| | ....|. ...|    |  .    ..   ...| |.||
aqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

ERSIRV-------GEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNaWphNNIPGNGSPKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFALFE
|.  ..       ...| ..  .  | . | | .|  .. ... ||  |  .. |  | |     | .|    |      |.|    .| ||.|.  ..|
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyh.w..idwpdrgvpaadlailellekarps..kgpivvhcsagigrtgsvvmle

TAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFC
     | . |   |  | |  .|. |  . |  .|. ||. .. ........ 
yildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkll

subfamily_Ptp69D_pd Subfamily Ptp69D 205-457 2.8e-22 74.2 In-house 27-286 (307) alignment
Range on Protein: 205-457
Range on HMM: 27-286/307.0
DFEQVV-SYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDS
..|..  . |. | .  .   |  |||. |..  |. .| |.      ||.|| ||...  . .|. |  | |.  |  |||.|| || |. . .|   .
eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlt

EYDSLGGDFVFPRNqDFLNFEerSIRVgEFKRVEIMDGWVLKVVSVSNGD-----YKSFLHI--HHYNAWPHNNIPGN--GSPKFVKQIWQLQSVLrkys
|..    .  .| . |  ...  .| | .. . | .. .. . ..||. .      .   ..  .||..|.  ..|    |  |...|. .|..      
eknrkkcakYWpie.devqyg..dilv.klvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln....

pSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
  .| |     | ||.|.|  ..     |. |. ..|...    .|. |    |.| |..|.|  |....
.rsPivvhCsaGvgrsgifvaldsllqqlkaed.kvdifetvkdLrsqRnllvqsleqYvflyralldys

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 220-458 6.6e-22 72.3 In-house 38-277 (515) alignment
Range on Protein: 220-458
Range on HMM: 38-277/515.0
HQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSL-GGDFvFPR-N
 |   | .|||. ... .| ..| |       .| |. |||.. .|..|  | .| |.. .  |||.......|  . ..   .| |    | . .|   
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgky.WPdkp

QDFLNFEerSIRVGEFkRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNgSPKFVKQIWQLQSVLRKYSpsTPTVYMSLSGCGRAGTFALFE
 | ..|   ||.|     .|   | . . . |  ||    .  .|.. ||.. .| . .  ..| | ....   .|.   | .   ..| ||.| .   .
gdsvkfG..sikvelv.sleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh.tssllklikevkadhgqyt..hpliihcsaGvGrtGvvisid

TAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
   ..   .  ..|. . .. .|. | .  |   |..|.|  . |..|
sv.vahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 219-460 1e-21 72.2 In-house 37-274 (288) alignment
Range on Protein: 219-460
Range on HMM: 37-274/288.0
KHQFVKNMHKNRFADVICLDHSKVHLSDSS--YIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLN
 ..|..|  ..|. .. . | ..|.||| .  ||.|  .      .| | .| ||  |   .|.|..|. |. ...|    |      .  || ..    
idsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

FEERSIRVGEFKRVEIMDGWVLKVVSVS-NGDYKSFLHIHHYNAWPHNNIPGNGSPKFvkqiwQLQSVLrkYSPSTPTVYMSLSGCGRAGTFALFETAHL
   |   |   ||..|    .. .. .| .|. | .. | |.. |... .| |  . .     .|  ||   |   | | .|  | ||.||..|   |  
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylspl.....rllevl..kslqkPivvhssaGvGrtgtlililiale

SLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
|| ..   | . . |.  |. | .| |   |. .|. .. |..|  
slrldd.flgirsllaklreerfkaiqtemqylyvhrcvleelllk

0051429 (Phosphotyrosine protein) phosphatases II 245-457 1e-21 73.3 In-house 2-225 (272) alignment
Range on Protein: 245-457
Range on HMM: 2-225/272.0
SDSSYIHASYLELDTQ----KRAILTQLPLPHTSADFWQMiIEQRVKCVLLLLTDSEYDSLGGDFVFP-----------RNQDFLNFEERSIRVGEFKRV
. |.||.|...   ..    .| .... |||.| ||||..  |...|... | ...|...|. |.. |           .   . ..   .... ...  
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

EIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPKFVKQIWQlqsvlrkyspSTPTVYMSLSGCGRAGTFALFETAHlSLHSEQATLD-----
. .  ..| .. ... .    ... || .||  ..| .   ...... .          . | ..   .|..| ||...         |... .|     
ldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld..........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYllt

---LVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
   | ...|..|  | .| |. .|. |.|  |.| .
nlyleeaveelraqrpgavqteeqylflyeallell

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 198-457 1.5e-21 71.3 In-house 18-279 (439) alignment
Range on Protein: 198-457
Range on HMM: 18-279/439.0
DANIAANDFEQVVSYIPP-----SVTKHQFvkNMHKNRFADVICLDHSKVHL------SDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQR
. .|  . ||.. |  |.     |.. ...  .  |||. ||  .||..| |        | || | |..   ..|  | || |  .|. |||...||..
kqeifkeifekinstspdyaciaslaaqey..dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekk

VKCVLLLL--TDSeYDslggdfVFPRNQDFLnFEERSIRVGefKRVEIMDgWV---LKVVSVS-NGDYKSFLHIHHYNAWPHNNIPGNGSpkFVKQI-WQ
.  .. |    .| |        .| ...   . . ..||   . .|. . .|   .||.    ... .  .   || |||..|.| . |  .| .    
tvtivmltnlves.yk......ywpsdaevc.ygdiavrvd..rnielpn.yvirgfkvfnerdttekertvlqfhyiawpdknvpaqas..hvldflra

LQSVlRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
..|         | |    .| ||.||   .. |   |..|.  .|.   ....|. | .  |.| |. |.|  . | |
insa.ndkeeygpvvvhcsagvGrtGtiialdialeqlklen.kvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 202-454 2.2e-21 70.8 In-house 9-266 (281) alignment
Range on Protein: 202-454
Range on HMM: 9-266/281.0
AANDFEQVVSYIP---PSV--TKHQFVKNMHKNRFADVICLDHSKVHLSD-------SSYIHASYLELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKC
. .||.| .| .|   ||   |  .   | .|||.... ||| |.|.|         . |||| |.     ||  |||| |   | ||||.|| ..   .
tlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentta

VLLLLTDSEYDSLGGDFVFPRNQD-FLNFEERSIRvgeFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNIPGNgSPKFVKqiwqlqsVLRKY-
...|    | .       ||||    |.|.. |.    ..   .    |   . .|      ..    .. ||  ..|.  |  ..|       .|||  
ivmlcqfletnrekcaeyfprnahcclqfdklsvs...yedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpes.sevmlk.......ilrkir

SPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVR-NGRIHACQNLTQFSFVYTLLA
. ||| |    .| ||.||.   | |  |.||  .  |. . .  .|  ||  . | | |. ... .| 
arstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll

subfamily_PTPRN_pd Subfamily PTPRN 204-457 1.9e-20 67.8 In-house 33-292 (297) alignment
Range on Protein: 204-457
Range on HMM: 33-292/297.0
NDFEQVVSYIPPSVTK--HQFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYL-ELDTQKRA-ILTQLPLPHTSADFWQMIIEQRVKCVLLLL
...| ...|     ||   .  ||..||| ..|.  |||.|.|.      .| || || . . | .. | | || ||..| ||||||. || |  .. | 
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

TDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVE--IMDGWVLKVVSVSngDYKSfLHIHHYNAWPHNNIPGNgsPKFVKQ-IWQLQSVLRKysPST
. .| .    .  .| .   .        | |    .  ..  . || .  |  . .. .   |. .||....| .  .| . .   ...   |    |.
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqts..etrt.vtqfhflswpeegvPas..aksllefrrkvnksyrG..rsc

PTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHI
| |  . .|.||.|.. | .     |      .|..  || .|. | .  .   || |..| .|| .
pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev

PTPc_DSPc_SM00012 352-455 7.9e-20 66.4 In-house 3-105 (105) alignment
Range on Protein: 352-455
Range on HMM: 3-105/105.0
HIHHYNAWPHNNIPGNGsPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
.  ||..||. ..| ..  .... ....... .| . |.|.| ..  |.||.|||....... .|..|. ..|. ......|. | ...|...|..|.|.
khyhytgwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

LLAE
 |.|
alle

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 206-456 8.1e-20 65.9 In-house 12-258 (267) alignment
Range on Protein: 206-456
Range on HMM: 12-258/267.0
FEQVVSYIPP--SVTKHQFVKNMHKNRFADVICLDHSKVHLSDS--SYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKcVLLLLTDSEYDS
||..    .    ...    ||  .||. |..  |...| |...   || |||.|   |..  |.|| ||  | .||...|..|.|  |  ||| .  | 
felikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvp.vivlltkvftdn

LGgDFVFPRNQDFLNFEERSIRVGefKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWphnNIPGNGSPkFVKQIWQLQSVLRKYSPSTPTVYMSLSGC
.   |  |.  .  .... ..        |  |  .. .    . .    . ...|. |   ||  |  | ..| .. . .  .    . | |     | 
ir.lfwPPkmgqakkyqdltvehs..lekeendyqiitlelkfknesahnvtlyyykkw...nintnnkp.ylkplfgilaknqlengnrPlvvacsdGv

GRAGTFALFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEH
||.|||   ..  |    .. ..|. . |  .|. ||   . . .. ... ||||.
GrsGtflvidsq.leraktegvsdifdflrkirsqriglvdtkeryiyihellaey

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 218-458 2.7e-19 63.8 In-house 38-237 (392) alignment
Range on Protein: 218-458
Range on HMM: 38-237/392.0
TKHQFVKNMHKNRFADVICLDHSKVHL------SDSSYIHASYL-ELDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDslggdfvfprn
|  |   |..|||. ... .| ..|.|      .|| |. |||.  .|..|  | .| | . .  |||.|. ...|  . ..    | |           
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

qdflnfeersirvgefkrveimdgwvlkvvsvsNGDYKSFLHIHHYNAWPHNNIPGNGSpKFVKQIWQLQSVLRKYSpsTPTVYMSLSGCGRAGTFALFE
                                 .|| .     .|.  || ...|   |  ..| | ....   .|.   | .    .| ||.|     .
.................................kgddartvaqfhftewPdkdvpkhts.sllkfikevkadfGqyt..hpliihcsagvgrtgvvisid

TAhlSLHS-EQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
.     |. .   .|... .  .|. | .  |   |..|.|  . | .|
sv..vahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 192-460 7e-19 62.6 In-house 16-292 (305) alignment
Range on Protein: 192-460
Range on HMM: 16-292/305.0
KRFVDEDANIAANDFEQVVSYIPPSVTKHQFVKN------MHKNRFADVICLDHSKVHLS---DSSYIHASYLEL--DTQKRAILTQLPLPHTSADFWQM
.| .|   .   ..| ..  |  | .|.  |  |      . |||..|| | |.| |.|.    | |||| |.      .|| | .| || .|  .|| |
lraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwm

IIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDG---WVLKVVSVSN-GDYKSFLHIHHYNAWPHNNIPgngspKFVKQI
.|...|. ...|    |   |     .|  |         | | .      |.      . .. ..  || |  .   ... ||   .|           
viqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvp.....pcklts

WQLQSVLRKysPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDN
 .| | .|      | |    .| ||.||    |     .  ..    . . .  .|. | .. ||  |. |.. .. ...|..
lellsairg..skvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

0046846 (Phosphotyrosine protein) phosphatases II 244-454 7.8e-19 63.6 In-house 9-170 (176) alignment
Range on Protein: 244-454
Range on HMM: 9-170/176.0
LSDSSYIHASYLELDtqkRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNfeersirvgefkrveimdgwvlkvvsvs
  |..||.|...  .   | | || |||.| |||..|. |.....|. |... |...|. .  .|. ...                              
dldldyinanlilgs...rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

ngdyksflhIHHYNAWPHNNIPGNgsPKFVKQIWQLQSVLRKYspsTPTVYMSLSGCGRAGTFALFEtahlsLHSEQATLDLVKCLEMVRNGRI-HACQN
          ...  || ...|      . . . .....|..     |..     |.||.||...       |   .  |.. ..|..||. |  .| |.
.........qylhlpwpDhgvpdl..elllellefirealkeg...gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqt

LTQFSFVYTLLA
  |  |.|  . 
peQyrflyefel

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 214-293 2.3e-18 60.8 In-house 41-126 (310) alignment
Range on Protein: 214-293
Range on HMM: 41-126/310.0
PPSVTKHQFVKNMHKNRFADVICLDHSKVHLS-D----SSYIHASYLELDTQKR-AILTQLPLPHTSADFWQMIIEQRVKCVLLLL
 .|.| . . |.|||||..||.||| |.|.|  |      |||| |.  .  .   | .| || ||  |||.||...| . .||| 
dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 210-455 5.8e-18 59.9 In-house 32-276 (287) alignment
Range on Protein: 210-455
Range on HMM: 32-276/287.0
VSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD--SSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFV
|.  . .||     .| .|||.....  |  .| | .    || |....    .|. |... |. .|  .||..| ...|. ...|  . | |       
vtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

FPRNQDfLNFEERSIRVGEFKrveIMDGWVLKVVSVSN---GDYKSFLHIHHYNAWPHNN-IPGNGspKFVKQIWQLQSVLRKYSpSTPTVYMSLSGCGR
.| ..  . . | .|.. . .   ...|.. . . | |    . |  .. ... .|. .  ..       . .| .     || .  |. |     . ||
Wpeeks.vvlGeyniellnee...vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepq..tillvieemyktqrkrg.ntsivvhCsdtvGr

AGTFALFETAHLSLhSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
...|   .|.      .. ..|... |.  |  . .. |  .|. |.. .. |
samfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivle

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 201-458 6.9e-18 59.5 In-house 10-267 (283) alignment
Range on Protein: 201-458
Range on HMM: 10-267/283.0
IAANDFEQVVsyIPPSVTK-HQFVKNMHKNRFADVICLDHSKVHLSDS--SYIHASYLE----LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLL
.  . ....   .|.  .. .   .| .|||. ...  |  .|.|     .|| |...      . .|. | .| || .|  |||.|. .... ....| 
lfrevlkrls..vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

TDSEYDSLGGDFVFPRNqDFLNFEERSIRVGEFKRveiMDGWVLKVVSVSN-GDYKSFLHIHHYNAWPHNNI-PGNGSPKFVKqIWQLQSvLRKYSPSTP
   |         .|..    .. |  . . .       . .. | . . . .  || | . ||      .. ..     .|| . ...| |.. |. .|
klqedlrikCsqyWPkr.GsedyGeftvtlrkett...snsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvis.lqteskkgP

TVYMSLSGCGRAGTFALFETAHLSLHSeQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 |    .| ||...|    ..   . . .. .|. . ....|. |. | |.| |. .|..|  |. |
ivvhCstgiGrtavfiaasasvkdalt.esvvdvfavvkimreqrmmavqtldqyklvhelvleqal

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 215-455 8e-18 59.3 In-house 36-281 (290) alignment
Range on Protein: 215-455
Range on HMM: 36-281/290.0
PSVTKHQFVKNMHKNRFADVICLDHSKVHLS------D--SSYIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDF
 .||     .| ..||||...  |  .. |       |   .||.|.|..    .|. |.|| |...| .|||..| ...| ....|..  | ..     
htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqq

VFPRNqDFLNFEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHYNAWPHNNiPGNGSPKFVKQIWQLQSVLRKYSpSTPTVYMSLSGCGRAGT
 .| . |  ...| ||.. . . .. .    |.| . .....|. .. ..  .|...    .     . .| . .   ||    |. |     . ||...
YWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrkrg.ntsivvHCSdtvgrsav

FALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
|   .|.    ..|.   |... |.  |  .    |   |. ...... .
fcaaattinkckteg.vidvfqvlksqRiqkpgsvqtvqqyqgifqivlt

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 225-451 1e-17 59.1 In-house 7-234 (239) alignment
Range on Protein: 225-451
Range on HMM: 7-234/239.0
NMHKNRFADVICLDHSKVHLS------DSSYIHASYLE-LDTQ-KRAILTQLPLPHTSADFWQMIIEQRvKCVLLLLTDS-EYDSLGGDFVFPRNQ-DFL
|  |||.|...  |||.| |        | || ||||   |   |  | ||  .  .| |||.|. ..| .||...||   |         .| .   . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqer.rcvivmltglieghkkkchqywpdstskyc

NfeersIRVGeFKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNnipgnGSPKFVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFE
|     .||  ... |..  .... . .|.     . ... .|.  || .     | |..   .  |.  . | |   . | |    .| ||.|.| . .
n.....lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk.....gvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

tAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
 | |    .| |.|... .. .|. | |  |   |. |.. 
.amlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 225-451 1.2e-17 58.9 In-house 8-235 (239) alignment
Range on Protein: 225-451
Range on HMM: 8-235/239.0
NMHKNRFADVICLDHSKVHLS------DSSYIHASYLE-LDTQ-KRAILTQLPLPHTSADFWQMIIEQRvKCVLLLLTDS-EYDSLGGDFVFPRNQ-DFL
|  |||.|...  |||.| |        | || ||||   |   |  | ||  .  .| |||.|. ..| .||...||   |         .| .   . 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqer.rcvivmltglieghkkkchqywpdstskyc

NfeersIRVGeFKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHYNAWPHNnipgnGSPKFVKQIWQLQSVLRKYS--PSTPTVYMSLSGCGRAGTFALFE
|     .||  ... |..  .... . .|.     . ... .|.  || .     | |..   .  |.  . | |   . | |    .| ||.|.| . .
n.....lrvt.lrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdk.....gvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

tAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
 | |    .| |.|... .. .|. | |  |   |. |.. 
.amlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

0043147 (Phosphotyrosine protein) phosphatases II 246-450 2.3e-17 58.7 In-house 4-154 (172) alignment
Range on Protein: 246-450
Range on HMM: 4-154/172.0
DSSYIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDseydslggdfvfprnqdflnfeersirvgefkrveimdgwvlkvvsvsn
.| ||.||||.|    .| | || ||..| ||||.|. |. ..... | .                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

gDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLR---KYSPSTPTVYMSLSGCGRAGTFALFETAHlslhseqATLDLVKCLEMVRNGRIHACQ
  |   |  ...  . . ..| .| |   ...... . ..     ||. |..     |.||.||...    .         |.| .....||. | .|.|
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavq

NLTQFSFVY
|  |  |.|
npsqyrfly

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 223-455 2.9e-17 57.4 In-house 36-275 (287) alignment
Range on Protein: 223-455
Range on HMM: 36-275/287.0
VKNMHKNRFADVICLDHSKVHLSD-----SSYIHASYLELDTQ-KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNF
. ...|||.|||. .|...| ||      |.|| | |.   |. .. | .| |.. |  |||....|.|.  |...  . |   |     .| ..  .  
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

EERSIRVGEFKRVEImDgWVLKVVSVSNGDYKS--FLHIHHYNAWPHNNIPGN--GSPKFVKQIWQLQSVLRKYSPSTPTVYMSLSGCGRAGTFaLFETA
   |. . ...  |  . .  . . . . . .    ..  .. .|| . ..    |  .|| .. |   . |. |   | |     | ||.|.. |   .
GGysvvlldydikeP.e.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil.latlv

HLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
 .|   .   .|  . .  .|. |    |   |. ..|  |. 
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvt

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 224-452 6.4e-17 56.6 In-house 2-234 (237) alignment
Range on Protein: 224-452
Range on HMM: 2-234/237.0
KNMHKNRFADVICLDHSKVHL----SDSSYIHASYLE-L-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFE
.|  |||...... |||.| |    |.| || |.||. .  | |. | .| ||  .  |||||. ...   ...|    | . |     .|  ..   . 
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

ErsIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIH--HYNAWPHNNIPGNGSP--KFVKQIWQLQsvlRKYSPSTPTVYMSLSGCGRAGTFALFEtAH
   . |   |. |. |  |  .. . ..  |    ||  .. .||.. .| . .   .| |.| .     .. | |.| .    .| ||.| | . . | 
v..ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrs...phvsesgpwiihcsagvgrtgiflvid.am

LSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTL
|    |.  .|. . .  . . | .  |   |. |..  
lrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqt

0036282 (Phosphotyrosine protein) phosphatases II 247-450 1.6e-15 52.7 In-house 2-163 (174) alignment
Range on Protein: 247-450
Range on HMM: 2-163/174.0
SSYIHASYLELDTQ-KRAILTQLPLPhtsadFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRnqdflnfeersirvgefkrveimdgwvlkvvsvSNG
|.||.||.| |    .| |..| ||.     ||.|. |.....|. ||.  | .. .    .|.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DYKSFLHIHHYNAWPHNNIPGNGSpkFVKQIWQLQSVLRKySPSTPTVYMSLSGCGRAGTFALFETAHLSLHseQATLDLVKCLEMVRNGRIHACQNLTQ
|.. . . ..|  || .. |      . . . .....| . .|. |..     |.||.||...    .  |.  . . | .. . ..|. | ...|.  |
dlerlgiqylylpwpDhgvpdlsi..llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQ

FSFVY
. |.|
yrfly

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 215-465 2.3e-15 51.1 In-house 33-284 (312) alignment
Range on Protein: 215-465
Range on HMM: 33-284/312.0
PSVTKHQFVKNMHKNRFADVICLDHSKVHLS--DSSYIHASYLELDTQK-RAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQ
.      |.|    ||. .. | |  .  |.  .  |||| .. . |.  | . || ||  |.. |||. .     ...|| .  |  |           
sdsectaflkfkdlnrypniqcwdrgrftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdiv

DFLNFEERSIRVGEFKRVEI-------MDGWVLKVVSVSNGDyKSFLHIHHYNAWPHNnipgnGSPKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAG
 |...|.  .       .||       .   |||||  . |. .| |  . . .||       | |  .    .| | ..|     | .    .| ||.|
gfvdledhrvyteycteieiggkskdkithrvlkvvvkatgq.esklnhyqwaswpdh.....gmpdscdtalrllsavkkd..kkpviahcsagvgrtg

TFALFETAHLSLHSEQaTLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHILDNGFCKL
|.|| |.   .|   .   .. . . ..|. |  . . . |. ..   . | .  .|. | 
tlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykr

0049260 (Phosphotyrosine protein) phosphatases II 261-450 3.1e-15 51.6 In-house 9-143 (152) alignment
Range on Protein: 261-450
Range on HMM: 9-143/152.0
KRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFprnqdflnfeersirvgefkrveimdgwvlkvvsvsngdyksflhihhynAWP
...| || |.|.| ||||.|. |. ..... | ...| . |. .. .                                                   . 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................qyl

HNNIPGNGSPKFVKQIWQLQSVLRK--YSPSTPTVYMSLSGCGRAGTFALFETAHlslhseqATLDLVKCLEMVRNGRIHACQNLTQFSFVY
| ..| .| |..   . .|  ...|   ... |..     |.||.||...    .         ..| .....||. | .|..|  |  |.|
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_ptpA1_pd Subfamily ptpA1 213-407 5e-15 50.1 In-house 34-247 (418) alignment
Range on Protein: 213-407
Range on HMM: 34-247/418.0
IPPSVTKH-QFVKNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDF
. || |   .  .|  |||..... ..|..|.|        | || | |..    |. | || ||| | ||||.|. |.|.. ...|  .||   .  | 
vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdr

VFPRNQ---DFLNFEERSIRVGEF--KRVEIMDGWVLKVV----SV-SNGDYKSfLHIHHYNAWPHNNIPGNGSP--KFVKQIWQLQSVL-RKYSPSTPT
 .| .    .|  . .    .| .  . ||...    ...     .  .|. .  .  ..|. ||  |||    |  .... | . |  .        | 
ywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd.itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpi

VYMSLSGCGRAGTFA
.    .| ||.|||.
ivhcsagvgrtgtfc

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 217-449 1.1e-14 48.9 In-house 42-273 (301) alignment
Range on Protein: 217-449
Range on HMM: 42-273/301.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSDS---SYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLG-GDFVFPRNQ
.|. .   . .|.|.  | |  .. |.. .      ||| ... .   .| | || ||. || ||| |..   |. . .|    |.      ...  . .
itesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis

DFLNFEERSIRVGEFKRVeIMDGWVLKVVSV--SNGDYKSFlHIHHYNawpHNNIPGNGSPKFVKQIWQLQSVLRKYspSTPTVYMSLSGCGRAGTFAlf
. |. .  .|.. . . . . .  . . . |  | |....   . ||.   ... . .| ||   ....|  ...|     | |    .| ||. .|   
ekldigrfkikiknkeli.lnkkiskrtlevedstgkfatr.tvthyq...ysewtdrgvPkshaelfdlmelvkks..ekPivvhcsaGiGrsvafi..

ETAHLSLHSE-QATLDLVKCLEMVRNGRIHACQNLTQFSFV
 |  |. . | . |..| . |. .|. | .. |. .|. ..
gteylareveadptieltealkhlrehrwngvqtnsqlywm

subfamily_egg_pd Subfamily egg 224-455 2.5e-14 47.7 In-house 39-268 (307) alignment
Range on Protein: 224-455
Range on HMM: 39-268/307.0
KNMHKNRFADVICLDHSKVHLS------DSSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLltDSEYDSLGGDFVFPRN-QDFLN
 |..| |   | | | |.|.|          .||| ... .      ||.| ||  |  |||.|. ...|. ...|  .|  .|   .. .|.  .| | 
nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml..tsrkeserceyywpkaesdslv

FEERSIRVGEFKRVEIMDGWvLKV--VSVsNGDYKSFLHIHHYNaWPHNNIPGNGSPkfvkqiwqLqSVLRKY-SPSTPTVYMSLSGCGRAGTFALFETA
.   |.|.  .|  .  |   ..|  . .  |  .  ... |.. .  ||     ||        |  ||||    |.|.|  .  |. .|.|.   |.|
tvpGslrienlkvdskadpl.frvtklkl.vGgddeerflehwq.gdvnnssdvysp........l.rvlrklrnlskpvvvqdilGvskaatlvaieia

HLSLHSEQATLDLV-KCLEMVRNGRIHACQNLTQFSFVYTLLAE
 |||     |  || ..  ..|  |  . .   .. ||| |.. 
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_eak_pd Subfamily eak 186-458 6.6e-14 46.0 In-house 12-306 (332) alignment
Range on Protein: 186-458
Range on HMM: 12-306/332.0
KWLGLAKRFVDEDANIAANDFEQVVSYIPP-SVTKHQFVKNMHKNrFADVICLDHSKVHLSDS-----SYIHASYLEL-DTQKRAILTQLPLPHTSADFW
||. . | .. .  |   |  ...  | .  |... . ......|   ...  |. .|.|. |      || || .|. .  .. ||| ..       ||
kwilinknhiwnrinqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafw

QMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQ-DFLNFEERSIRVGEFKRVEIMDGWVLKvVSVSNGDYKsfLHIHHYNAWPHNNIPG-----------
||..||.  ... || | | .    |  || .  . |.|    .   || . .|..   |. .|. |  ..  .. ...  |   ..|            
qmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvkrniletrlle.lskGnethr..vlhykvfGwtettlpkyedflalrkvm

--NGSPKFVKQI-WQLQSVLRKYSPSTPT---VYMSLSGCGRAGTFALFETAHLSLHSEQATL-DLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
   | ....      |.|.|.||  . |.   .  |  |  |||.| . .     . . .  |  . . .  |.. |||.     | ||.| .. ...|
kevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 208-299 1.7e-11 38.2 In-house 78-175 (244) alignment
Range on Protein: 208-299
Range on HMM: 78-175/244.0
QVVSYIPPSVTKHQFVK-NMHKNRFADVICLDHSKVHLSDSS----YIHASYLE-LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD
| .    ||| |  |   | .||| .  . .| ..| || .|    || ||..  |      |||| ||  || |||.|..|. |. ...| .  | |
qniirpdpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed

0044763 (Phosphotyrosine protein) phosphatases II 245-455 2.4e-11 39.1 In-house 16-169 (178) alignment
Range on Protein: 245-455
Range on HMM: 16-169/178.0
SDSSYIHASYLEldtqKRAILTQLPLphtsADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDflnfeersirvgefkrveimdgwvlkvvsvsn
  | ||.||.       . .|..||     ||..... |. ..... | .. |.  |. |  .|.. .                                
ersdyinaseil....pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

gdyksflhihhyNAWPHNNIPGNGSPKFVKQIWQLQSVLRKY--SPSTPTVYMSLSGCGRAGTFALFETAHLSlhseqaTLDLVKCLEMVRNGRIhACQN
              . | .||..| |   ......   ....  ..  |..     | ||.||...    .         |.| ...|.||. |  ...|
............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivpn

LTQFSFVYTLLAE
  |  ..| .  .
pgqlrqLyefelr

0051082 (Phosphotyrosine protein) phosphatases II 247-452 2.4e-11 38.9 In-house 3-148 (151) alignment
Range on Protein: 247-452
Range on HMM: 3-148/151.0
SSYIHASYLEldtqKRAILTQLPLPhtsaDFWQMIIEQRVKCVLLLLTDSEYDslGGDFVFPRNQdflnfeersirvgefkrveimdgwvlkvvsvsngd
|.||..||..     . .... ||.    ||.... |. .|... | .. |..       .|...                                   
sdyinfsyvt....gglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

yksflhiHHYNAWPHNNIPGNGSPKFVKQIWQLQSVLRKySPSTPTVYMSLSGCGRAGTFALFETAHLSlhseqatLDLVKCLEMVRNGRIHACQNLTQF
       ...  .|  . |  | | . ... .. ..|..  .. |..    .|.|| ||...    .|        ..| ..||..|  | .. |  .||
.......ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqf

SFVYTL
 |..  
lfqlfa

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 206-292 6.1e-11 36.4 In-house 18-116 (347) alignment
Range on Protein: 206-292
Range on HMM: 18-116/347.0
FEQVVSYIPPSVTKHQFVKNMHKNRFADVICLDHSKVHLSD-----------SSYIHASYLELDT-QKRAILTQLPLPHTSADFWQMIIEQRVKCVLLL
 |.. .| |. .|  .. |.. |||  ||   | ..| ||             .|| ||.. .|  .|  |||| |||.|  |||.|.   .|  |. .
denlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 223-299 8.6e-11 36.1 In-house 45-142 (350) alignment
Range on Protein: 223-299
Range on HMM: 45-142/350.0
VKNMHKNRFADVICLDHSKVHLS--------------DSSYIHASYLELD-------TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD
|. . |||. ...  .||.|.|                . || |.||.|        .. . | || ||| |  ||...|..  || .| | .| |..
velfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdveln

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 248-457 3.7e-10 32.9 In-house 99-309 (346) alignment
Range on Protein: 248-457
Range on HMM: 99-309/346.0
SYIHAS---YLELDTQKRAILTQLPLPH---TSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDGWVLKVVS
.|.|     .. .. ... |..|||  .      ||| || ..... | |.. |         ..   |  .       |             . ..|. 
ayvhlvvlyfvifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlp

VSNGDYkSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSvlRKYSPSTPTVYMSLSGCGRAGTF--ALFETAHLSLHSEQATLDLVKCLEMVRNGRIha
  | |     ..||.  | | . | .  |  .| | |. |   |   ..    .|| ||||| .|  ||.    |    |   ....| .   | | .  
egnsds.vicqvhhhapwkhlqqppktlp.iikmihqfls..ekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggv..

cQNLTQFSFVYTLLAEHI
 . ..|.. .|... ..|
.esfaqyasiyaivfdyi

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 241-451 4.9e-10 34.0 In-house 41-253 (290) alignment
Range on Protein: 241-451
Range on HMM: 41-253/290.0
KVHLSDsSYIHASYLELDTQKRAILTQLPLPHT-------SADFWQMIIEQRVKCVLLLLTDSEYDSLGGDF----VFPRNQD-FLNFEERSIRVgefKR
. ...|  ||||...      | |||| |. ..         .|| |. . .|| |  |   .| ..  ..|     .| . .  |.|.  ...    | 
gkrfnd.dyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC...ks

VEIMDGWVLKVVSVSNGDYKSFLHIHH-YNAWPHNNIPGNgspkfVKQIWQLQSVLRkySPSTPTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVK
 |  |.   . . |  .| . |   |. .. | . |.. .      | . .| . ..     || .     |  |  ..|  . .   .   .  . |..
kekeddvetRelvvkfddeeeftvtHsllkgWnklnvqed.....tktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkled

CLEMVRNGRIHACQNLTQFSFVYT
 |...|. | .| .. ....||  
vlkalrkqralaitsalelafvda

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 233-307 4.1e-09 30.2 In-house 75-152 (349) alignment
Range on Protein: 233-307
Range on HMM: 75-152/349.0
DVICLDHSKVHL-SDSSYIHASYLEL---DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLlTDSEYDSLGGDFVF
 ||   .|. .      || | ||.|   ...|. | || ||| |  ||...|. ..|| || | .|..  ||.   ..
kvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL.nddkelslekcdiy

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 218-297 7.9e-09 29.6 In-house 33-121 (301) alignment
Range on Protein: 218-297
Range on HMM: 33-121/301.0
TKHQFVKNMHKNRFADVICLD--------HSKVHLSDSSYIHASYLELD-TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSE
| .   .| . ||| ..  .|        .....|.  .|| |||..    .|. | .| |. .| .|||..|.....  .. .    |
tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 265-457 1.9e-08 28.7 In-house 39-221 (255) alignment
Range on Protein: 265-457
Range on HMM: 39-221/255.0
LtqlplphTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDF-LNFEERSIRVGEfkrveIMDGWVLKVVSV--SNGDYKSFLHIHHY--NAW
|       | . |.|.|. .. . | .|    | .    .  || ..|  | ... .. . .      .   ||. . .    |. |    ..||  . |
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.....ssadvvlrtleitstlgekkkthtvkhysykGW

PHNNipgngSPKFVKQIWQLQSVLRKyspSTPTVYMSLSGCGRAGTFALFETAHL----SLH-SEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLA
. .|     .|.  ..| ..  | |.   | . | .  .| ||. .|.| | ..     ||. .| . || .. || .|. |  | ..  |..|   .. 
iekn.....aPelareilnilkvvrd...sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl

EHI
. .
dlv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 222-291 6e-08 26.9 In-house 30-106 (297) alignment
Range on Protein: 222-291
Range on HMM: 30-106/297.0
FVKNMHKNRFADVICLDHSKVHL----SDSSYIHASYLELDTQK---RAILTQLPLPHTSADFWQMIIEQRVKCVLL
    ..|||. |..  | ..|.|    ... || | |. .  ..   . ||.| ||  |  |||... || |. . .
rnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivm

0048179 (Phosphotyrosine protein) phosphatases II 339-451 8.5e-08 27.6 In-house 33-139 (144) alignment
Range on Protein: 339-451
Range on HMM: 33-139/144.0
VVSVSNGDYKSFLHIHhYNAWPHNNIPGNGSPKFVKQIWQLQSVLRKY-SPSTPTVYMSLSGCGRAGTFALFETAHlslhseQ-AtLDLVKCLEMVRNGR
|...... .. ||  .    . | ..|..| | . ... ..   .... ... |..     |.||.||...    .          |.| ..|..||. |
vinlteeyepeflere.giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klg.lsleealalvrsrr

IHACQNLTQFSFVYT
 .|..|  |. |.. 
pgavpnpgqlrfLle

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 217-291 1.4e-07 25.3 In-house 26-106 (332) alignment
Range on Protein: 217-291
Range on HMM: 26-106/332.0
VTKHQFVKNMHKNRFADVICLDHSKVHLSD----SSYIHASYLELDTQKRA-ILTQLPL-PHTSADFWQMIIEQRVKCVLL
 |  .|..||  ||   . |.|||.| |.       .  ||...  ..| | |..| |.  ||   ||.|. |..   .|.
ntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilv

0048076 (Phosphotyrosine protein) phosphatases II 347-454 1.4e-07 26.8 In-house 41-140 (145) alignment
Range on Protein: 347-454
Range on HMM: 41-140/145.0
YKSFLHIHHYNawpHNNIPGNGSPKFVKQIWQLQSVLRKYSPS-TPTVYMSLSGCGRAGTFALFETAHLslhseqATLDLVKCLEMVRNGRIHACQNLTQ
.  . .. .|    . ..|..| | . ......   .... ..  |..     |.||.||...    .|        ..| ..||.||. | .|..|  |
ellerlgiqyl...ylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavpnpgq

FSFVYTLLA
. |.| .. 
lrflyefel

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 240-299 2.3e-07 25.2 In-house 6-66 (130) alignment
Range on Protein: 240-299
Range on HMM: 6-66/130.0
SKVHLSDSSYIHASYLEL-DTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD
    | .  ||.||.. | .  .  .||| ||  || |||.|..|. |  ...| .  | |
evsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed

subfamily_CG42327_pd Subfamily CG42327 225-387 3e-07 24.4 In-house 28-198 (319) alignment
Range on Protein: 225-387
Range on HMM: 28-198/319.0
NMHKNRFADVICLDHSKVHLS------DSSYIHASYLE--LDTQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYD-SLGGDFvFPRNQDFLN
   |.|...|. | ...| |        . |..|||.    |..   | .| .|  .|.|||... ||. . .. |   ||       .. .| ..   |
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaey.lPtketldn

FEERSIRVGEFKRVEIMDGWVLKVVSVSNGDYKSFLHIHHY-NAWPHNNIPGNGSPkFVKQIWQLQSVLRKYS
 .        .|  |. | ...  . . . | .   .. ||   |.. ..| . .. ..  . . .| |. ||
tslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywykwleaevPaeeaa.liamllevrsslksys

subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 220-322 1.1e-06 20.4 In-house 24-122 (275) alignment
Range on Protein: 220-322
Range on HMM: 24-122/275.0
HQFVKNMHKNRFADVICLDHSKVHLSDSSYIHASYLELDTqKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEydsLGGDFVFPRNQDFLNFEER
..|..| .||||..| |.|.   . ..  ..||. .        ...| |   |.||. ...    |. |. |..  |    || ||    . |  |.  
erfirngeknrftnvtcfdeildrenqeffvhantfrtpy.gnflisqapndstnadhlhllwiynvqtvvclvlpee...aggyfvpkegetftsfqky

SIR
 |.
qik

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 259-451 1.3e-06 22.7 In-house 3-198 (199) alignment
Range on Protein: 259-451
Range on HMM: 3-198/199.0
TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNfEERSIRVGEfKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHY
.|.| | || || .| ||||||. |     ....  |         | .|  .     .  |. |   | .     ... .. ..|      |   | ||
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kygslsvtt.ktittkpdytitaliltnnttappstreishy

N--AWPHNNIPgnGSPKFVKQIWQLQSVLRKYSP--STPTVYMSLSGCGRAGTFALFETAHLSL-HSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
.  .|  .  |      ||  .   . | .||     .| .     | | .| |  ..    |   |  . .|| .    .|. |      | .. |.| 
qftswkekttp..nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq





subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 259-451 1.4e-06 22.7 In-house 2-197 (198) alignment
Range on Protein: 259-451
Range on HMM: 2-197/198.0
TQKRAILTQLPLPHTSADFWQMIIEQRVKCVLLLLTDSEYDSLGGDFVFPRNQDFLNfEERSIRVGEfKRVEIMDGWVLKVVSVSN--GDYKSFLHIHHY
.|.| | || || .| ||||||. |     ....  |         | .|  .     .  |. |   | .     ... .. ..|      |   | ||
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtg.kygslsvtt.ktittkpdytitaliltnnttappstreishy

N--AWPHNNIPgnGSPKFVKQIWQLQSVLRKYSP--STPTVYMSLSGCGRAGTFALFETAHLSL-HSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYT
.  .|  .  |      ||  .   . | .||     .| .     | | .| |  ..    |   |  . .|| .    .|. |      | .. |.| 
qftswkekttp..nvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq





subfamily_CG42327_pd Subfamily CG42327 391-455 2.6e-06 21.4 In-house 249-313 (319) alignment
Range on Protein: 391-455
Range on HMM: 249-313/319.0
PTVYMSLSGCGRAGTFALFETAHLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAE
| |     | ||.|.    . |  ||   . ..|. . .  ||..| .| ..  |. |.|  | |
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 295-458 4e-06 20.4 In-house 38-195 (440) alignment
Range on Protein: 295-458
Range on HMM: 38-195/440.0
DSEYDSLGGDFVFPRNQDFLNFEERSIRVGEFKRVEIMDgwVLkVVSVSNGDYKSFLHIHHYNAWPHNNIPGNGSPkFVKQIWQLQSVLRKYSpSTPTVY
 |.  ||  . |  | .. | ..   . . | | |   |   .   |  ||     |. .||..|| . .|   .|  .| | ...    | . . | . 
psdiaslpnnkvknryrnilaydhsrvmleevkgvpdsd..yi.nasyingiesrtlkqyhyqgwpdkgvpkfagp.vlkmiqdvnesqekag.ngpllv

MSLSGCGRAGTFALFETAhLSLHSEQATLDLVKCLEMVRNGRIHACQNLTQFSFVYTLLAEHIL
 . .|.||.|     ..  |        .|..  .. .|| | .  |   |..||.  . | .|
hcsagagrtgviiavdsi.lreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavlegll