Gene F40G12.10 in Caenorhabditis elegans

Synonym: CELE_F40G12.10, F40G12.10

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP081_AA protein Get Run
CeleP081_AA_123-402 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 120-416 1e-118 390.2 In-house 2-301 (302) alignment 
Range on Protein: 120-416
Range on HMM: 2-301/302.0
NVEKGVKVWIELLEKMDFRKT-----MEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTtKSTILAQLAIV
.||.... |.|  |.... |.     ...|||.|||||.|||||.|||||....|||.|...|.|.||...|.|.....|....|..| .|.|||||..|
kveeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkv

DSPQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP---EDFKEFKTIRVNNRKtVPKTEEQAnTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP
||..|.|.|| ||...||....||.|||||.| ||||.||   .|.||.....||||| |.|.||.. |....||.|..|.....|.......|...|.|
dsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrk.Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp

tMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKDPALKI
 . |.....|||.||...|..|....|||..||||||.|.....|.||||.|..||||||. |.|||||.|...|.||...|...|.|..|.|..|. | 
.vkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekk

KTEKV
|.|.|
kkeev
0036941 (Phosphotyrosine protein) phosphatases II 131-403 1e-41 138.5 In-house 5-280 (297) alignment 
Range on Protein: 131-403
Range on HMM: 5-280/297.0
LLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQSLESFWIMVAS
||||..|.  .. ||. .. .... . .......|..  .. ..  || .||| ..| . ....| ....... |  |..|      |...|.|| ||  
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk.fIatqgPl...pntvedFWrmvwe

QKIQRLFILLGEEELDKPTLSEYFP---EDFKEFKTIRVNNRKTVPKtEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPT--MGYNRIAATAAS
|... .  |  ..||....  .|.|   ....... ..|.....  . ...  |. . ||..... |  . ..  .  ||| ..|.    . ..   . .
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

VFeSDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ---AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
|  . .  .    . .. | ||.|.| .| |... |.     . ..|.|. ...|.||| |..||.||.| | . | . .|.
vl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0040438 (Phosphotyrosine protein) phosphatases II 124-432 1.9e-41 137.7 In-house 4-308 (317) alignment 
Range on Protein: 124-432
Range on HMM: 4-308/317.0
GVKVWIELLEKMDFrKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQS
... ....| |.|| . .. ||. ....| |  .. ....|.|. .. .. .|| .|||    || . . ... |  ..|. ..|  |..|      |..
dlllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk.fIatqgPl...pnt

LESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYN
.|.|| ||  |... .  |  .|||....  .|.| ..........|......    ..  | .  ||..... |  . ..  . .||| ..|  .    
vedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdlll

RIAATAASVFEsdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKDPALKIKTEKV
..   . ...|   | .  ... .. | ||.|.| .| |..| |. .. ....|.   .|.||| |..|..||.| | ..| | ....... .. .  |.
dfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl

ISQLEQFACEKMTEED
. .|. .|........
lklliplalddvklke
0050432 (Phosphotyrosine protein) phosphatases II 115-404 3.6e-41 136.9 In-house 18-303 (308) alignment 
Range on Protein: 115-404
Range on HMM: 18-303/308.0
SGNVKNVEKGVKVWIELLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGgGEADFFYHGSTLTIPS-VTTKSTILAQLA
| .|.. .  |. ...||||..... .| ||. .  .| .|| .. ....|.|. .. ..  || .|||  .| . ... |  ...|   ..  |..|  
silvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgP

IvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE----DFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDA
    |...|.|| ||  |...    |  ..| ....  .|.|.    ...|.. ..|.....     ..  |. ..|...... |  . ..  .  ||| 
l...pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev...lddytvrtleltnlgdgesrtvthfhytnWpdh

KIPT--MGYNRIAATAASVFesdidCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHV
..|.    . ..   . ...      .  ... .. | ||.| | .. |..| |...  ... |.   .|.||| ...|..||.| | ..| | ....
gvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0043336 (Phosphotyrosine protein) phosphatases II 134-399 1.1e-39 132.0 In-house 15-276 (278) alignment 
Range on Protein: 134-399
Range on HMM: 15-276/278.0
KMDFRKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAivdSPQSLESFWIMVAS
......... ||. ....| |  .. ....|.|. .. .. .|| .|||    || . . ... |... ..|..|  |..|     .|...| || ||  
llnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk.fiatqgP...lpetvedFwrmvwe

QKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFE
.... .  | ...||....  .|.|..........|...|.     ..  |.   ||... . |  . ..  .  ||| ..|  .  . ..  .. ...|
lgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeeh...lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale

sdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
   |..   .. .. | ||.| | .. |..| |. .  ... |.   .|.||| |..|.|||.| | ..| |
...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 167-397 1.9e-38 127.6 Pfam-A 4-234 (235) alignment 
Range on Protein: 167-397
Range on HMM: 4-234/235.0
FSQSENVELYDTNRVKG---GGEADfFYHGSTLTIPSvTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEF
  .....  || .|||    .|. | ... ....  . ..|. |..|      ....|.|| ||  .|.. ...|  .|| .. ....|.|   |.....
knRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

KTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEA-PFA-MIEICDFWPDAKIPtMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIE
..|.|...  . ..|......|.   . |...|  ..  .   .  ||| ..|   .. .  .  .| .|  ...... ...  |.||.|.| .. ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
.|.|.| .....|  ..|.||| ....|.||.| | . |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 167-397 1.9e-38 127.6 In-house 4-234 (235) alignment 
Range on Protein: 167-397
Range on HMM: 4-234/235.0
FSQSENVELYDTNRVKG---GGEADfFYHGSTLTIPSvTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEF
  .....  || .|||    .|. | ... ....  . ..|. |..|      ....|.|| ||  .|.. ...|  .|| .. ....|.|   |.....
knRykdilpydktrvklkgsegpsd.YInAnyvkgyk.ekkkfIatQgP...lkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

KTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEA-PFA-MIEICDFWPDAKIPtMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIE
..|.|...  . ..|......|.   . |...|  ..  .   .  ||| ..|   .. .  .  .| .|  ...... ...  |.||.|.| .. ...|
gdikvelk..ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp.espkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldille

KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
.|.|.| .....|  ..|.||| ....|.||.| | . |
qleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0039614 (Phosphotyrosine protein) phosphatases II 122-403 3.1e-38 127.3 In-house 15-292 (297) alignment 
Range on Protein: 122-403
Range on HMM: 15-292/297.0
EKGVKVWIELLEKMDFRKTMEPEFKPIDTMKADlEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADF-----FYHGSTLTIPSVTTKSTILAQLAivdS
  .|. .. ||||.... ... ||. .  .| |  .. ....|.|. .. ..  || .|||  .| ..     ... | .. ....|.  |..|     .
plsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP...l

PQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFPEDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAeaPFAMIEICDFWPDAKIP--TMG
|...|.|| ||  |... .  |  ..||.. .  .|.||.  ......|...|.     ..  |. . ||.....    . .   .  ||| ..|  .  
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkveh...ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslel

YNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
  ..   . ...... . .  ... .. | ||.|.| .| |..| |. .  ....|.   .|.||| |..|.|||.| | ..| . ...
lleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045450 (Phosphotyrosine protein) phosphatases II 126-400 4e-37 124.0 In-house 14-304 (307) alignment 
Range on Protein: 126-400
Range on HMM: 14-304/307.0
KVWIELLEKMDFRKTMEPEFKPIDTMKADLE---KCQAFKKNIDFSQSENVELYDTNRVKGGG-----EADFFYHGSTLTIPSV-------TTKSTILAQ
 ... ||.. ||.  .. ||. .  .. .|    .. ....|.|. .. .. .|| .|||        | . ....|  ..|..        ..  |..|
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

LAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDfKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPK-DCAEAPFAMIEICDFWPDAK
      |...|.|| |.  |... .  | ...||...   .|.|.. .|..|..    ... .....  | ...|| ..  . |  . .. ..  ||| .
gPl...petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhg

IP--TMGYNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEA---PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
.|  .    ..   . ...|.. ...  ... .. | ||.|.| .| |... |....    ... |.   .|.||| |.....||.| | ..| . 
vppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 129-399 2.3e-36 121.1 In-house 2-271 (273) alignment 
Range on Protein: 129-399
Range on HMM: 2-271/273.0
IELLEKMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKsTILAQLAIvdsPQSLESFWIMV
. ||||........ ||. .  .| .|. .. ....|.|. .. ..  || .||| |.. . ... | .. . .. |  |..|      |...|.|| ||
llllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk.fiatqgPl...pntvedfwrmv

ASQKIQRLFILLGEEELDKPTLSEYFPED----FKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAAT
  |... .  |  ..||....   |.|..    ..... ..|.....     ..  |.   |...... |  . ..  .  ||| ..|  .    ..   
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet...kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

AASVFESDIDCdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. ...|....     .. .. | ||.|.| .. |... |...  ....|.   .||||| ...|..||.| | ..| |
vrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0051299 (Phosphotyrosine protein) phosphatases II 122-399 1e-34 115.8 In-house 8-285 (288) alignment 
Range on Protein: 122-399
Range on HMM: 8-285/288.0
EKGVKVWIELLekMDFRKTMEPEFKPIDTMKADLE-KCQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAIvds
|. .|.. .||  ... .... ||. .  ...||. .. ....|..  .. ..  || .|||    .| | . ... | ....  . |  |..|      
eellklvlkll..angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk.fIatqgPl...

PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPK----DCAEAPFAMIEICDFWPDAKIP
|...|.|| ||  |...   .| ...||.. .   |.| ....... |.|......    ..  |. . ||...     . |  . ..  .  |||  .|
pntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev...lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

TmGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.   . . .    | ..  ...  ... .. | ||.| | .. |..| |.... ... |.   .|.||| ...|..||.| | ..| |
d.spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
DSPc_SM00195 144-399 2.3e-33 111.0 In-house 5-261 (263) alignment 
Range on Protein: 144-399
Range on HMM: 5-261/263.0
EFKPIDTMKAD-LEKCQAFKKNIDFSQSENVELYDTNRVKGGGE----ADFFYHGSTLTIPsVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFIL
||. ..... .   .....||| .  ...|. .|| .|||   |     . ... . ....   .|. |..|      |. .|.|| ||  .|..   .|
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivml

LGEEELDKPTLSEYFPED---FKEFKTIRVNNRKTVPKTEEQANTQLyyEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDidcD
  ||| .| . ..|.||.    ..|..|.|.....  | .|   ..|  |.  ... |. ..    .  ||| ..|  |.   ..  .. .  ..    .
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...s

ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . ...  | ||.|.| .. ....||.... ..|.||  ..|.||| ...|| ||.| | ..| |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 144-399 2.3e-33 111.0 In-house 5-261 (263) alignment 
Range on Protein: 144-399
Range on HMM: 5-261/263.0
EFKPIDTMKAD-LEKCQAFKKNIDFSQSENVELYDTNRVKGGGE----ADFFYHGSTLTIPsVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFIL
||. ..... .   .....||| .  ...|. .|| .|||   |     . ... . ....   .|. |..|      |. .|.|| ||  .|..   .|
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPl...pstvedFWrmvweekvkiivml

LGEEELDKPTLSEYFPED---FKEFKTIRVNNRKTVPKTEEQANTQLyyEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDidcD
  ||| .| . ..|.||.    ..|..|.|.....  | .|   ..|  |.  ... |. ..    .  ||| ..|  |.   ..  .. .  ..    .
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtl..eltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...s

ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. . ...  | ||.|.| .. ....||.... ..|.||  ..|.||| ...|| ||.| | ..| |
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0046845 (Phosphotyrosine protein) phosphatases II 141-403 1.5e-32 108.5 In-house 2-277 (284) alignment 
Range on Protein: 141-403
Range on HMM: 2-277/284.0
MEPEFKPIDTMKADLE---KCQAFKKNIDFSQSENVELYDTNRVKGGG-----EADFFYHGSTLTIPS----VTTKSTILAQLAIvdsPQSLESFWIMVA
.| ||. .  .. .|.   .. ....|..  .. ..  || .|||        | . ... | .. ..     ..|  |..|      |...|.|| || 
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl...pntvedFwrmvw

SQKIQRLFILLGEEELDKPTLSEYFP--EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKD-CAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAA
 |... .  | ...| ..   . |.|  ....... ..|.....     ..  |.   |..... . |  . ..  .  ||| ..|  .    ..  .. 
eqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseev...kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

SVFESdIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGE---APNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
...|. ....   .. .  | ||.| | .. |..| |....    ... |.   .|.||| ...||.||.| | ..| | ...
ellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0042113 (Phosphotyrosine protein) phosphatases II 157-399 2e-31 104.7 In-house 2-242 (245) alignment 
Range on Protein: 157-399
Range on HMM: 2-242/245.0
KCQAFKKNIDFSQSENVELYDTNRVKGGGEA----DFFYHGSTLTIPSVTTKsTILAQLAIVDspqSLESFWIMVASQKIQRLFILLGEEELDKPTLSEY
.......|.|. ..... .|| .|||   .     . ... |  . . .| |  |..|    .   ..| || |. ...|. .. |  ||||....  .|
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqy

FP-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESdiDCDASCAIVSNYGAGRAGS
.| ..........|.....     ..  |. ..||... . |  . .   .  ||| ..|  .    ..   . .. ..  | .  ... .. | ||.| 
wplgesltygdftvtllseeh...lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGt

FFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| .| |..| |..    .. |.   .||||| |..|.|||.| | ..| .
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0040439 (Phosphotyrosine protein) phosphatases II 158-400 1.6e-29 98.7 In-house 5-246 (249) alignment 
Range on Protein: 158-400
Range on HMM: 5-246/249.0
CQAFKKNIDFSQSENVELYDTNRVK----GGGEADFFYHGSTLTIPSVTTKsTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYF
.  ...|.|  .. ..  || .|||    .|.. . ... | .. . ....  |..|      |...|.|| |.  ..|. .  |  ..||.. .  .|.
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr.fiatqgP...lpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

P-EDFKEFKTIRVNNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP--TMGYNRIAATAASVFESDiDCDASCAIVSNYGAGRAGSF
| ....|.....|.....     ..  |. . |.... . |    .   .  ||| ..|  .    ..   . ...|.. ...  ... .. | ||.| |
plggsleygdftvtllsvev...kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtf

FVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
 .| |..| |.     ...|.   .||||| |.....||.| | ..| . 
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 159-397 1.3e-25 85.8 In-house 5-239 (243) alignment 
Range on Protein: 159-397
Range on HMM: 5-239/243.0
QAFKKNIDFSQSENVELYDTNRVKGGGeaDFFYHGSTLTIPsvttKSTILAQLAIVDSPQS-LESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF
  .. |..  .  .. .|| .||| .|  . .....  ...    .  |. |.   .. .. |.||| |. ...|. .  |  ..||..    .|.|...
allpenlsknrysdilpydhsrvkleg..sdyinanliyvt....prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev

kEFKTIRVNNRKTVPKTEeqaNTQLYYEVVPKDCAEAPFAMIEICDF-WPDAKIPT--MGYNRIAATAASVFES-----DIDCDASCAIVSNYGAGRAGS
 ......|.. ..  . .    |. .......|. . ..  | .. . ||| ..|.      ..   . .. |.      .| .  ...    | ||.| 
.tygdftvtllseehldd...ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGt

FFVAVLAIEKLqagEaPNIKEIALSVRSQRPA-AIETLSQYMFTYVIAL
. .| | ...|   .  .. |.   .|.|||  |..|.|||.| | ..|
liaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 204-400 1.6e-21 70.3 In-house 115-309 (346) alignment 
Range on Protein: 204-400
Range on HMM: 115-309/346.0
KSTILAQLAIVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED--FKEFKTIRVNNRKTVPKTEEQANTqlyYEVVPKDCAEAPFAMIEI
.  |.|||  ...   .| || |.  ..|. ..... .. | . | | .  |.  ..    . .|||..    . .  |    ||.|.  ...  . .  
hklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeyt...ievlpegnsdsvicqvhh

CDFWPDAKIPTMGYNRIAATAASVFESDIDCdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
   |   . |      |        | ..   |   .|| .|.||| ||  |. ||..|. |  ||| ||  ... ||| ..|...||   | | . | 
hapwkhlqqppktlpiikmihqflsekqvqn.agvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi
0045098 (Phosphotyrosine protein) phosphatases II 160-401 3.5e-20 68.0 In-house 29-273 (278) alignment 
Range on Protein: 160-401
Range on HMM: 29-273/278.0
AFKKNIDFSQSENVELYDTNRVKgggeaDfFYHGSTLTIPsvtTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-K
 . .|.|.    ..  || .|||     | . . | ....   .|  |..|      |. ...|| |. ...|. .  | ...||..    .|.||.  .
lylgnldknRykdilpydhsrVk.....d.YINAsyidgy...pkkfIatqgP...lpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsl

EFKTIRVNNRKTVPKtEEQANTQLYYEVVPKDCAEAPFAMIEICD--FWPDAKIPTMGYNRIAATAASVFESDID--------------CDASCAIVSNY
... ..|.. ..    ..   . |... .    .. . . ... .  .|||  .|.. . .    .    .. ..               .  ...  ..
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GAGRAGSFFVAVLAIEKLqaGEAPNIKEIALSVRSQRPA-AIETLSQYMFTYVIALTYGL
| ||.| . .| | .| |  ..  .. |.   .|||||  |...|.||.| |  .| . |
GvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 217-399 2.4e-19 64.7 In-house 109-289 (298) alignment 
Range on Protein: 217-399
Range on HMM: 109-289/298.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE-DFKEFKTIRVnnrkTVPKTEEQANTQLYYEVVPKDC--AEAPFAMIEICdFWPDAKIPTM
....| || ||  ..|. . .|   ||||| . ..|.|.   ... .|.|    .. ..||.|.       | |     |    ...    |||  .|..
tetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitv....sllskeefadlivrklkvskkkeekerevrqlhft.sWpdkgvpen

GyNRIAATAASVFESDIDCD-ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
  . . .  . |  |  ..  ..  .    | ||.|.| .    .|.... .   . ..   .| .||.|..| .||.| | . | .
a.tsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 204-399 3.4e-18 60.7 In-house 52-241 (250) alignment 
Range on Protein: 204-399
Range on HMM: 52-241/250.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPtLSEYFP-EDFKEFKTIRVNNRKTvpktEEQANTQLYYEVVPKDCAEAPFAMIEI-
|. | .|  ..   ...| || ||  .|.. . .|   .| .|   ..|.| |  ...  ..|.  ..    || |. .    .. |   .    . .. 
kafiatqgPlq...atiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaekyGdvtvsllsk....eefadytkrklklskakkaderivrqlh

CDFWPDAKIPTMgYNRIAATAASVFESDIDCDASCAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
   |||  .| . .. . .    |  |.  ....  ||    | ||.|.| .    .|.|.  .  .. ..   .| .|| |.|.|.||.| | |.| .
fvvWPdkgvPev.atavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPN13_pd Subfamily PTPN13 131-398 3.9e-18 60.7 In-house 4-267 (273) alignment 
Range on Protein: 131-398
Range on HMM: 4-267/273.0
LLEKMDFRkTMEPEFKPIDTMKADlEKCQAFKK--NIDFSQSENVELYDTNRVKGGGEADfFYHGSTLTIPSvtTKSTILAQLAIVDSPQSLESFWIMVA
| .|.|   . . ||| .  .|.  ..|.  ||  | |  .  ||  ||  ||| |.|.  .   | . .|    | .  . ..    |.. . || || 
lqkkldqq.qPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvw

SQKIQRLFILLGEEELDKPTLSEYFPEDFKefKTIRVNNRKTVPKTEEQANTQLY-YEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIAAtAASV
 || . . ..  | | .|     |.||  .  |.. |.|| .| . . |   ..   ..  || . .    .   .|  ||| ..|.   . .   .| |
eqkaeviamvtlekekgkvkchrywPeskn..kklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqf.vaev

feSDIDCD-ASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
    .. | .  ..    | ||.|.. .   ... ..  .  ..|||  ..| || . . |  ||.| | ..|.
..rrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPRD_pd Subfamily PTPRD 217-421 4.4e-17 56.9 In-house 101-305 (564) alignment 
Range on Protein: 217-421
Range on HMM: 101-305/564.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTvpktEEQANTQLYYEVVpKDCAEAPFAMIEICDF--WPDAKIPTM
....| || ||  |...   .|   || .|  ...|.||.  ...  . |.  ..    || |. ..    . |.  .    ...   |  |||  .|. 
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleee....eeladyeirtfkl.kkkkssesreVrqFhFtsWPdhgvpes

GyNRIAATAASVFESDiDCDASCAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY---GLKHVKDPAL
. . . .    | ..   .|| . .|  . | || | | |    .|.... .  .| ..   .|.||.| ..| .||.| . . | .   | ..|.  .|
a.tslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl

KIKTEKVISQLE
| ...|. .. |
kqhlqkLaevee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 160-399 1.2e-16 55.6 In-house 37-275 (281) alignment 
Range on Protein: 160-399
Range on HMM: 37-275/281.0
AFKKNIDFSQSENVELYDTNRVKGG---GEADFFYHgSTLTIPSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED
  ..|.   .  |.  ||  |||      . .  |      .|... .   .|  . |  |.||..|| || .||.. . ..  | | .|     |.|.|
kadenvlknrYsnivaYDatrvkvtpneenkntDYi.nanfvpgykgekeyiatqgPv..PaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

FKEFKTIRVNNRkTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICdFWPDAKIPTMGYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLA
 .| |   |  . .. ..|..   .  ...  ... .   . ..    |||  .|.   . .   ..    .. . .|.  |    | ||.|..     .
nselkygdvtvk.staeeekatyierkfkleresgetreveqlayt.aWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrl

IEKLQ-AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.....   |  ..|..  ..| .|   . |. || | | . | .
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
PTPc_DSPc_SM00012 304-396 6.5e-16 53.8 In-house 9-103 (105) alignment 
Range on Protein: 304-396
Range on HMM: 9-103/105.0
FWPDAKIPTMGyNRIAATAASVFESDIDCD--ASCAIVSNYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
 ||| ..|. . . |  . ..| ..  ...  ... ...  |.||.| | .. .....|... . ..|..|  ..|.||| ...|. ||.| | . 
gwpdhgvPees.dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
subfamily_PTPN23_pd Subfamily PTPN23 156-399 1.5e-15 51.7 In-house 35-279 (288) alignment 
Range on Protein: 156-399
Range on HMM: 35-279/288.0
EKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKSTILAQLAivdSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE
  . . |.. .  .|...  || ||||  |. | .   | .   | .. . | .|      ...|  || || .|| . . .|| .|||.||  ..|.||
rsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaP...lqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

DF---KEFKTIRVNNrKTVPKTEEQANTQLYYEVVPKDCAEAPFAMieICDFWPDAKIPTM--GYNRIAATAAS-VFESDIDCDASCAIVSNYGAGRAGS
|    ..|. ..|   | | .||.  . .|  |. ..|  .    .      ||.  .|     . ..   . |   .    ...   .    | ||.| 
dkgetvkfgdlsvtl.ksvretethvervlkletldadavksvshl..qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

FFVAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . . |...|..|.  ..| ..   .| ||   ... .|. |.| . |..
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Ptp69D_pd Subfamily Ptp69D 141-403 4.1e-15 50.7 In-house 24-289 (307) alignment 
Range on Protein: 141-403
Range on HMM: 24-289/307.0
MEPEFKPIDTMKADLEKCQ-AFKKNIDFSQSENVELYDTNRVKG---GGEADFFYHGSTLTIPSVTTKSTILAQLAIvDSpqSLESFWIMVASQKIQRLF
.. |.. . . . |..    . | |    ..|..  .| .|||     |..|  |  .   .    .|. | ||  . ..   .. || |.| |... . 
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv.ea..tigDfWRmiaeqevtliv

ILLGEEELDKPTLSEYFP-EDFKEFKTIRVNNRKTvPKTEEQANTQLYYEVVPKDCAEAPfAMIEICDF----WPDAKIPTMGYNrIAATAASVFESDID
.|  ..| ..   . |.| || ...  | |.  ..  |... .. .|..  . .. .| . .  ..  .    |.| |.| .    .      | |    
mlsnlteknrkkcakYWpiedevqygdilvklvse.ekhsdyiiReldvskkkeesgeve.dsrkvvqyhytgWkDskvPevarg.llklieqvrelykl

CDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKH
  .   .  . |.||.| |    . ...|.| .  .| |.   .||||.  .. | ||.| |   | |  . 
nrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRA_pd Subfamily PTPRA 218-404 4.5e-15 50.3 In-house 112-302 (330) alignment 
Range on Protein: 218-404
Range on HMM: 112-302/330.0
QSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTVpKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMG
...| || |.  || . . .|   .| ..     |.|..    .  |||. ....  ... .  ..  . .|. . | .  ...   |  |||  .|. .
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedet.vlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfep

YNRIAATAASVFESDIDCDaSCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLK---HV
   .   ..     .  .. .  .    |.||.|.| |    .|...| .  .. |.  ..| |||  . |. || | | . | | |     .
iGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 141-399 5e-15 50.4 In-house 22-279 (318) alignment 
Range on Protein: 141-399
Range on HMM: 22-279/318.0
MEPEFKPIDTMKADLEKCQAFKK-NIDFSQSENVELYDTNRVKGG---GEADFFYHGSTLtIPSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLF
.. |.. ..  ..   . .. .. |    .  |.  ||. |||     || .  |  .   |.  . | . .|  | .  |. .| || ||  |. . . 
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinany.idGyrrkkayiaaqaPl..petieDfWrmvWeqnsaviv

ILLGEEELDKPTLSEYFPED-FKEFKTIRVNNRKTVPKTEeqaNTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAAtAASVFESDIDCDAS
.|  |||  |  .  |.|..  .......|. ...|  ..    .   ..|  ... |        .  |||  .|. | . ..    .| . . ...|.
mltqeeergkakvhryWPskgsrsygklvvelkeevelsd...yvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldl.vrqvskaqqksgag

CAIVS-NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
. .|    | ||.| | .    .|...| .  .. ..   .|.||.. . | .|| | | . | .
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_PTPN14_pd Subfamily PTPN14 141-399 1.3e-14 48.9 In-house 25-295 (300) alignment 
Range on Protein: 141-399
Range on HMM: 25-295/300.0
MEPEFKPIDTMKADL-EKCQAFKKNIDFSQSENVELYDTNRVKGGGEAD--F-FYHGSTLTIPSVTTK-STILAQLAIvdsPQSLESFWIMVASQKIQRL
. .|.  |  ...|   .. . ..| . .. ..|  |. |||.     .    .   |.. ..  ... | | ||  .   .. .. || ||  |..| .
vfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl...eltvqdfWqmvWeqgvqli

FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRK----TVPKTEEQANTQLYYEVVPKDcAEAPFAMIEICDfWPDAKIPT-----MGYNRIAATAASVF
 .|  |||  |    .|||.. .. ||.. .. |     . ...  . |.|  . .|    |    ..   | ||| ..|      . | .        .
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk.eertvwhlqytD.WpdhgvPeDvkgflsyLeevqsvrrkt

ESDID---CDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.| ..    .    .    |.||.|   .. | |. |. .|  .||..   .| ||   ..||.|| | | . ..|
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 152-399 1.4e-13 45.5 In-house 31-270 (288) alignment 
Range on Protein: 152-399
Range on HMM: 31-270/288.0
KADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTipSVTTKSTILAQLAIVdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSE
.|  .  ..| .|    . ||.   |. |||   ..||. .   ..  |   |  ..   | .     .| .| |. .. .. . .|    |. |.   |
easidiidsfianptrdryenlprcditrvklsddpdfyiaanvvs..sakykrrlicaqaPl..ngtieelWkmllesdveyivmlcellekGkeksae

YFPEDFKEFKTIRVNNRKTVPKTeEQANTQLYYEVVP--KDCAEAPFAMIEICDFWPDAKIPTM--GYNRIAataaSVFesdIDCDASCAIVSNYGAGRA
|||    |   |. .   .  |  .. .  .   ..   |   |. .  |     |.|  .|     . |.      |.    ...    . |. |.||.
yfPsklGekarigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll....evl...kslqkPivvhssaGvGrt

GSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| . . ..|.| |.  .   |...  . | .|  ||.|  ||.. . . | .
gtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 137-397 1.6e-13 45.4 In-house 19-276 (288) alignment 
Range on Protein: 137-397
Range on HMM: 19-276/288.0
FRKTMEPEFKPIDTMKADLEKCQAF-KKNIDFSQSENVELYDTNRVKGGG---EADFFYHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKI
 |. .. |.. . ... . .....   .| .  . .|.  || .|||  .   ||.  |  ..    .  .|  | .|  .   ..... || .|  .|.
nrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl...adtvndfWelvyenkt

QRLFILLGEEELDKPTLSEYFPEDFK--EFKTIRVNNRKTvPKTEEQANTQLYYEvvpKDCAEAPFAMIEIcDFWPDAKIPTMGYNRIAATAASVFESDI
. .  | .  | .| .  ||.|.. |  ..  . |  ...  ..|.  . .|  |   |.  |      .    ||| ..|    . ..        .. 
stivmltelveggktkCeeYWPdadkpknyGsvtvtlves.keledfvlrkllle...kkkteleitqyqy.laWpdhgvPeskapllellrqvkvanqa

DcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
|      ..   | ||.| | ..  .|..... .  .. ..   .| ||.  ..||.||.| | . |
d.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 125-406 3.5e-13 44.2 In-house 3-283 (307) alignment 
Range on Protein: 125-406
Range on HMM: 3-283/307.0
VKVWIELLEKMDFRKtMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRV--KGGGEADFFYHGSTLTIpSVTTKSTILAQLAIvDSpqSLES
|| |..   ..  .. .  ||. .  .. .    .||. | |  . ..|.  | .|.  |  | |  . |   | | ..  |  | ||    ..  .  |
vkpwvqrtldkgvqa.lvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgi.aikpkkficaqgpl.en..tqys

FWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-------KEFKTIRVNNR--KTVPKTEEQANTqLYYEVVPKDCAEApFAMIeICDFWPDAKIPTM
|| |.  .|.. . .|    || |    .|.| .        .. .|| |.|   |..   |.  |     .|.  . . .    .   . |||  .| .
fwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinv.ttlkvdwaqksrt.iqhl.qwenwpdrgvpqi

GYNRIAATAASVFEsdidcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKD
  . |    |  ..          .    | ||.|.     |  .|. ||.   ..|..   .||||. ||.|  ||.. . . | | |.  |.
nltainlleavryd.....tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 217-399 6.7e-13 43.3 In-house 83-267 (274) alignment 
Range on Protein: 217-399
Range on HMM: 83-267/274.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKE-----FKTIRVNNRKTVPKTEEQAnTQLY--YEVVPKDcaeapfAMIEICDFWPDAK
|. .. || |.  ...| . .|   .| ..   ..|||.. .      .. . ....|.| . . .  ..|.  |   ...       .      ||| |
pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysv.rklvlkylerers......vkhywytdWPdhk

IPTMgYNRIAATAASVFESDIDCDASCA---IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 |    | .  . . | ||  . .| .|   .    | ||.| |  . .|. .|.. .  .. .|   .| .|   ..| .|| . . .   |
sPdd.antlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 130-402 9.6e-13 42.5 In-house 15-289 (305) alignment 
Range on Protein: 130-402
Range on HMM: 15-289/305.0
ELLEKMDfrKTMEPEFKPIDTMkADLEKCQAFKKNIDFSQ--SENVELYDTNRVKGGGEADFF-YHGSTLTIPSvTTKSTILAQLAIvDspQSLESFWIM
. |||.   . .  ||. .  .  |.|| .|||.  .  .    .|   | ||||  |       |   .. |.  .|  | .|  . .  ..   || |
rtlekgp..aglraefvamkrf.ndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstpt.npkrfictqapl.e..ktcadfwym

VASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKD-----CAEAPFAMIEIC-----DFWPDAKIPTMGYn
   .|.. .|.|    |      .|||. . |.  ... ...| . | |  .. ..  .   |        | | .  .         |||  .|.    
clqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl.

riaaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAP-NIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLK
    .   ..|         ..    | ||.||  .    ...| ||.   . . |   .| ||  .|.|  ||.| . . | | .|
....ailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 138-399 1.4e-12 42.3 In-house 22-282 (319) alignment 
Range on Protein: 138-399
Range on HMM: 22-282/319.0
RKTMEPEFKPIDTMKADLEKCQAFKKNIDFSQSENVELYDTNRVKGG---GEADFFYHGSTlTIPSVTTKSTILAQLAIVDspQSLESFWIMVASQKIQR
 ...| ||| ... ..|  .    ..| .  . .|.  ||  ||.     |  .  |  ..  | .   ..  .|  | ..  . .| || ||  ...  
etllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinas.fidgyqerekfiatqaPle..ntiedfWrmvWeeessi

LFILLGEEELDKPTLSEYFPEDF-KEFKTIRVNNRKtVPKTEEQANTQLYYEVVPKDCAEapfAMIEICDF--WPDAKIPTMGYNRIaATAASVFESDID
. .| .  |  |  |..|.||   .|.  . |.  .   ..|.    .|  .    .       ..    .  ||| ..|. .   . .    . .|   
vvmltklveklkvklkkywpeenfeeyGrlivtlee.eeeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekatsll.dllkrirksrek

CDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 ..   .|    |.|| |.| |   ..|...  .. .. ...  .| ||.  ... .|| | | . | .
tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPN1_pd Subfamily PTPN1 141-412 5.1e-12 40.1 In-house 8-282 (290) alignment 
Range on Protein: 141-412
Range on HMM: 8-282/290.0
MEPEFKPIDTMKADLEKCQA-FKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVtTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILL
 .. .. |.    |..  .| ...| .  .  .|. ||  |.|   .   .   | . .. .  .| ||.|  .   |.  . || ||  || . . .| 
ykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradndyinaslveleea.krsyiltqGPl...pntvdhfWqmvWeqkskavvmln

GEEELDKPTLSEYFPEDFK--EFKTIRVNNR-KTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNrIAATAASVFESDI-DCDAS
   | ..    .|.|.. .  |..   .. . | . . ...  |   .|.  . . |.   .      |||  .|    .        | ||     |  
kvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaa.flkflfkvresGslssdvG

CAIV-SNYGAGRAGSFFVA---VLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYViALTYGLKHVKDPALKIK
 |..    | ||.|.| ..   .. ||| .  .. .||.  | .|..|   | |  |  |.|. |.  | | .|...   |
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsyl.aileGakvikgdssvqk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 139-394 7.8e-12 40.0 In-house 22-277 (305) alignment 
Range on Protein: 139-394
Range on HMM: 22-277/305.0
KTMEPEFKPIDTMkADLEKCQAFKKNIDFSQSENVELYDTNRVKGGGEADFF---YHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRL
|..| ..| . .   .  . .  ..|   ...... |.|..|..   . .     |  ..        |. |.||  .   .. .. || ..   |.. .
kgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPl...kntvadfWrliveekvsti

FILLGEEELDKPTLSEYFPEDFKE---FKTIRV--NNRKTVPkteEQANTQLYYEVVPKDCAEAPFAMIEICDfWPDAKIPTMGYNRIAATAASVFESDI
 .| .  | .|     |.||  .|   |  . |  ...||..   .  . .|   .  .|  .      .. | |||  .|..    .        .   
vmltklveggkdkCrqYWpesktekkefgefsvelksektas...dyieRklkisiededkesrtvlqyqltd.WPdhGvpqfatsllslikrvqkdqkk

DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYV
| . .  .. . | ||.| | .  .|.|.|.. |  .. |.   .||.|. ...|| ||.| . 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhd
subfamily_PTPN12_pd Subfamily PTPN12 216-399 1.2e-11 39.0 In-house 92-276 (290) alignment 
Range on Protein: 216-399
Range on HMM: 92-276/290.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKE---FKTIRVNNRKTVPKTEEQANTQLYYEVVpkdCAEAPFAMIEiCDFWPDAKIPT
 |. |. || |. ..... . ..  | ||.|     |.||  .|   | ...|.. .    ...    .|  |.     ..  .  ..    |||  .|.
LpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq...kesrkvyqfh.YtaWPDhgvPs

MgYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAP---NIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
   ... .  ..| |   . ||  ..    | ||.|   .  .. | |.|.  |   .. .. |..| ||.|.. |  || . |   . .
s.aksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavael
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 159-396 1.3e-11 38.7 In-house 42-275 (303) alignment 
Range on Protein: 159-396
Range on HMM: 42-275/303.0
QAFKKNIDFSQSENVELYDTNRVKGGGEAdfFYHGSTLTIPsvTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE--D
. | ||.|  .  .|   |  .||    .  . | | | .   ..| .||.|| .   ...   || |.  ||.. ...|| . | ||      ||.  |
nqfvknmdknrfvdvicldhskvklsdss..yihasyleld..sskkailtqlpl...shtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd

FKEF--KTIRVNNRKTVPKTEEqanTQLYYeVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAAT---AASVFESDIDCDaSCAIVSNYGAGRAGSFF
| .|  ..||| . | |  ..     .|   .   .     |  .   . || ..||. |  ..        ||.    |.      .|  | ||||.| 
flkfeersirvgefkrvelgdg...wvlkv.lsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfa

VAVLAIEKLQAGEA-PNIKEIALSVRSQRPAAIETLSQYMFTYVIA
.   |   |.. .|  ..      ||  |  |.. |||. . | . 
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_PTPN3_pd Subfamily PTPN3 162-392 1.7e-11 38.5 In-house 39-267 (280) alignment 
Range on Protein: 162-392
Range on HMM: 39-267/280.0
KKNIDFSQSENVELYDTNRVKGGGEA-DFFYHG-STLTIPSVTTK-STILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK
 .|..  .  ..  ||. |||   .  |.       . ||| ..    | .|  .   ... . || ||  ||.. . .|    |  .    .|.||  .
penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPl...aktatdfWqmvweqksslivmlttlverGrvkChqyWPeted

EFKTIrvnNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIaATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLA
|..     . . . . |.. .. .. |.| || ..    .|    .  ||| ..|.   . .     .| .     .    .    | ||.| . .  .|
eleyg...efsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadfl.efvervrklrsgkeePvvvhCsaGigrtGvlilleta

IEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFT
. ...| |. .. .|   .| || . ..| ||| | 
lalieaaepvypldivrtmrdqramlvqtasqykfv
0046846 (Phosphotyrosine protein) phosphatases II 211-395 2.9e-11 38.9 In-house 19-168 (176) alignment 
Range on Protein: 211-395
Range on HMM: 19-168/176.0
LAIVDS--------PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEdFKEFKTirvnnrktvpkteeqantqlyyevvpkdcaeapfamIEIC
|.. .         |..|..|. |. ...|. .. |. | ||..  .  |.|| .....                                       ..
lilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgi....................................qylh

DFWPDAKIPTMgynRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEklqaGEAPNIKEIALSVRSQRP-AAIETLSQYMFTYVI
  |||  .|..   ..  ..    .. .. .   ..    | ||.| . .| | .     .   .. |.   ||.|||  |..| .|| | |  
lpwpDhgvpdl...elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyef
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 166-399 4.4e-11 37.2 In-house 46-276 (315) alignment 
Range on Protein: 166-399
Range on HMM: 46-276/315.0
DFSQSENVELYDTNRVKG-----GGEADFFyhGsTLTIPSVTTKSTILAQLaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE---DF
   . .|.  .|..|||        . |..    .  |.|| .  . .|       . |.. || ||  .|.  . ..   .| ||     |.|.   | 
kknryknilPldsarvkleviddsPdsdyi..n.asyiksvdddkayiasq..gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

KEFKTIRVNNRKTVPKTEEQAnTQLyyeVVPKDCAEAPFAMIEICDfWPDAKIPTMGYnRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAI
 || .|.|.  .. . |.  |  .|   |. |  .    .  .  . |||  ..      .      |  ..   . |  .    |.||.| .  .   .
vefGsikvellsleadtdgva.rkl...vtrkseesrtvtqfqfte.wPdkGvdkqts.sllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

EKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.... ... .. ..   .|..||  . |  .| | | . | .
aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_CG7180_pd Subfamily CG7180 158-401 6.2e-11 36.5 In-house 36-291 (296) alignment 
Range on Protein: 158-401
Range on HMM: 36-291/296.0
CQAFKKNIDFSQSENVELYDTNRV---KGGGEADFFYHGSTLtIPSVTTKSTILAQLAIVDspQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP
..  |.|..  .  .|  || |||   | .||..  |  ..  . | . |   .   | ..  .....|| .|  ..|. . .|  . .  |    .|.|
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavy.vdsflkkkeyivteapkk..etvdefWrlvydeeisavvvLtktfdfak.mypsywp

ED-FKEFKTIRVN--NRKTVPKTEeQANTQLYYEVVPKDC----AEAPFAMIEIC--DFWPD-AKIPTM--GYNRIAATAASVFESD--IDCDASCAIVS
..  .... | |.  . |. .. . . . .|. ..|         .|.  ..       |.   |.|    ..  .   . .. |     .  .   .||
nkskeqygeifveiveekqyanlk.irtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvs

NYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGL
. ||.|.| .. .  ..|...  |  .. | .  .| .||  .|.  .|.. | . | . |
sdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
0036282 (Phosphotyrosine protein) phosphatases II 209-393 8.7e-11 37.3 In-house 17-163 (174) alignment 
Range on Protein: 209-393
Range on HMM: 17-163/174.0
AQLAIVDSPQSlesFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEdfkefktirvnnrktVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDA
  | . . | .   || |. ...|. .. || |.||..     |.||                .. .|. . |..|  .| ...     ..|...|  .|
prliagqgpla...fwemlkelgittvvmlleekelglykcinywpe...............lredlerlgiqylylpwpDhgvpdlsillefvkfveea

KiptmgynriaataasvfeSDiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQaGEAPNIKEIALSVRSQRPAAIETLSQYMFTY
                   |. | .  ...  . | ||.| . .| | .  |    . .. ..  ..|.||| ...| |||.| |
l..................se.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 163-406 9.6e-11 35.9 In-house 54-295 (305) alignment 
Range on Protein: 163-406
Range on HMM: 54-295/305.0
KNIDFSQSENVELYDTNRVKGGGEAD-FFYHGSTLTIPSVTTKSTILAQLAIvDspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFK
 .|   . ..|   | . ||    .   . |   .  | .  |  | ||  . |  |... || ||  .|.... .|    || |   ..|.|    | .
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpl.d..qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekl

TIR----VNNRKTVPKTEEQANTQLYYEVVPK-DCAEAPFAMIEICDfWPDAKIPTMGYNRIAATAAsVFESDIDCDASCAIvsnyGAGRAGSFFVAVLA
...    |.|       | .|. |.    .      .     .. .. |||  .|      .   .| .  | .     |.     | ||.|.       
elksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwte.wpdrgvppckltslellsa.irgskvpivvhcsa....gigrtgtivaieyi

IEKLQ-AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGLKHVKD
.||.    ..| . |.  ..| ||  .|..  ||.| . . | | |.. |.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
0041856 (Phosphotyrosine protein) phosphatases II 164-399 1.1e-10 36.9 In-house 1-170 (182) alignment 
Range on Protein: 164-399
Range on HMM: 1-170/182.0
NIDFSQSENVELYDTNRvkgggeadffyhgstltipsvtTKSTILAQLAIVDSPQ------------SLESFWIMVASQKIQRLFILLgeeeldkptLSE
|.|    ...  || .|                        . |.| | . . |.            ....|. |. ...|. .  |             
nldknrysdilpydhsr......................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eel

YFPEDFkefktirvnnrktvpkteeqantqlyyevvpkdcaeAPFAMIEICDFWPDAKIPTmgYNRIAATAASVFEsdidCDASCAIVSNYGAGRAGSFF
|.||..                                        .  .. .|||  .|.   . . .    | |     .  ...  ..| ||.|.. 
ywpell....................................erlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlv

VAVLAIEKlqageAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.| | ...       .. |.   |||.|| ...|..|| | . ..| .
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 216-399 3.2e-10 34.5 In-house 73-263 (270) alignment 
Range on Protein: 216-399
Range on HMM: 73-263/270.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGY
 | .|.||| |. ..| . . .. | ||  .   . |.|.. ||  ...  . |..  .||...  .  ..  .. .|    .      |||  .|..  
lpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreed

-----NRIAATAASVFESDIDCDAS-CAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
     . . .. . | .|  . | .   .|    | ||.| . .   |.. |.  .  .. .|   .| .|.| ...  || | |   ..|
sslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
0051429 (Phosphotyrosine protein) phosphatases II 218-399 3.5e-10 35.5 In-house 33-224 (272) alignment 
Range on Protein: 218-399
Range on HMM: 33-224/272.0
QSLESFWIMvASQKIQRLFILLGEEELDKPTLSEYFP-------------EDFKEFKTIRVNNRKTVpkTEEQANTQLYYEVVPKDCAEAPFAMIEICDF
 . ..|| . ....|   . | .|||...   . | |             . . ..  .|| . ...  . .      .. .   .  ||.  |.  .  
ltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee..llldyilrellltlllsagearevmhlhytd

WPDAKIPTMGYNRIAATAASvfesdidcDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPN--------IKEIALSVRSQRPAAIETLSQYMFTYVIA
|||  .|.  . .. .  ..        .  . .  . | .| | . ...| .. . .    .        . |.   .|.|||.|..|  ||.| | ..
wpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal

LTY
| .
lel
subfamily_PTPRK_pd Subfamily PTPRK 217-398 4.8e-10 33.7 In-house 96-275 (314) alignment 
Range on Protein: 217-398
Range on HMM: 96-275/314.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTqlyYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMG
.. .. || .|  ..   . .|    |  .   ..|.||| . .. |.|.  .| ...|  . .   . |     .   . ..   .|  ||| ..|.  
qetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvri...frveklargqeeirevrqfqflgWpdhdvPvsa

YNrIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
   . .  . | .|. . .    .    ||||.| | .    .. ..  .  .. ... ..||...  .||  ||.| | ..| 
tg.llklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 216-396 5.1e-10 33.8 In-house 101-275 (315) alignment 
Range on Protein: 216-396
Range on HMM: 101-275/315.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQlyyEVVPKDCAEAPFAMIeiCDFWPDAKIPTMGY
 ..|.. || .|  ..| .. .| .  | .|    .|.|..   .  | |  ..   .||    |     || .|  .  . .      |||...|    
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtl...svvfgdnirevvqlh..ytswpdmgvpkyti

NRI--AATAASVFESDIdcdASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
. .    |.    ....   ..  .  . | ||.|.|      .....| .| .. ..   ||..|  ..... || | | . 
plmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydal
0043147 (Phosphotyrosine protein) phosphatases II 207-393 8.7e-10 34.1 In-house 22-154 (172) alignment 
Range on Protein: 207-393
Range on HMM: 22-154/172.0
ILAQLAIvdSPQSLESFWIMVASQKIQRLFILLGEeeldkptlseyfpedfkefktirvnnrKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWP
..| ..    .  |..|| |. ...|. .. | ..                            . |. .|. . |..|  .|  ..  .  ..|...|  
fiatqgp..lrntladfwrmlkelgithivnltel...........................lydpellerlgiqylylpwpDhgvpllellleflefid

D--AKIPtmgynriaataasvfesdidcDASCAIVSNYGAGRAGSFFVAVLAIeklQ-AgeapNIKEIALSVRSQRPAAIETLSQYMFTY
.  |. |                     .  ...   .| ||.| . .| | .   .      .. |.   ||..|| |... |||.| |
ellalsp.....................ggpvlVHCsaGvgRtgtlvaaylml...lgl....sleeavalvrekRpgavqnpsqyrfly
subfamily_PTPRB_pd Subfamily PTPRB 141-393 9.2e-10 33.0 In-house 27-278 (293) alignment 
Range on Protein: 141-393
Range on HMM: 27-278/293.0
MEPEFKPIDTMKADLEKCQA-FKKNIDFSQSENVELYDTNRVKG---GGEADFFYHGSTLtIPSVTT-KSTILAQLAIvdsPQSLESFWIMVASQKIQRL
.  |.. . ... | .. .|  ..| .  . .|.  ||..|||     .|..  |  .   ||  .. .  | .|  .   |.... || ||  .| . .
fseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany.ipgynsprefiatqGPl...petvddfWrmvwekkssii

FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRktVPKTEEQANTQLYYEVVPKDCAEAPFAMIEIcDFWPDAKIPTMGYNRIAATAASVFESDIDCDAS
 .|    |  |    ||.|.| ..     ..    . ..||. .  .    . |. .|      .    |||  .|    . .. . .   . . .....
vmltqlvekgkvkCeeYWPadeepvlyGdikvt..lvaeeeledwvirelkiekekeerkvrqyhf.tsWpdhgvPektktlldfvrtvreaiektaskr

CAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTY
  .|    | ||.| |      .....  .  .|  |  ..|..|   . | .||.| .
PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifih
0049260 (Phosphotyrosine protein) phosphatases II 217-393 1.8e-09 33.0 In-house 19-143 (152) alignment 
Range on Protein: 217-393
Range on HMM: 19-143/152.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFpedfkefktirvnnrktvpkteeqantqlyyevvpkdcaeapfamIEICDFWPDAKIPTMGYN
|..|..|| |. ...|. .  |  ..||.|.   .|.                                               .. .|||   |..   
pntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpwpDhgvpdlsql

RIAATAASVFEsDIDCDASCAIVSNYGAGRAGSFFVAVLAIeklqagEAPNIKEIALSVRSQRPAAIETLSQYMFTY
 . .  .  .   .| .  ...   .| ||.| . .| | .         ...|.   ||..|| |... .|..| |
llflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPN9_pd Subfamily PTPN9 217-402 4.8e-09 30.7 In-house 95-292 (297) alignment 
Range on Protein: 217-402
Range on HMM: 95-292/297.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP---EDFKEFKTIRVNNRKTVPKTEeQANTQLYYEVV-PKDCAE-APFAMIEicdfWPDAKIP
..  . || ||  |..  . .    .|  .   ..|.|   |. .||  ..|.| ... . .    ..|  . |  ..  .   | ..     |||  .|
kktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeed.ykvrvleiknvkteesrkvthfqfls....WPdyGvP

TMGYNRI-----AATAASVFESDI------DCDASC-AIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
  . . .     .  . ... ...      ...     .    | ||.| |    .....|.  .  .. |    .|.||  .| |  ||.| |.  | |
ssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley

GLK
 |.
ale
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 159-400 5e-09 30.5 In-house 30-270 (285) alignment 
Range on Protein: 159-400
Range on HMM: 30-270/285.0
QAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPSVTTKSTILAQLAIvdsPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK
 |.. | |. .  .|   .  ||        . | | . .|     . | .|  .   |..|  || |.  .||  ...|    |      . |.|| . 
tayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl...petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklg

EFK-TIRVNNRKTVPKTEEQANTQLYYEVV--PKDCAEAPFAMIEI-CDFWPDAKIPTMGYNRIAAtAASVFESDIDCDASCAIVSnYGAGRAGSFFVAV
|     . .   |  | |  | | |    |   .|..  |. |  .   .|||   |      |      | . .      |  .|  | ||. .|    
evvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmiel.ykwvkkvnpkekpicvhcs.agvgrtatfvgid

LAieKLQAGEAPNIK--EIALSVRSQRPAAIETLSQYMFTYVIALTYG
 |   ..  | |||.  .|   .|. |  |...  |..| ||. . | 
ya..tirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 216-404 6.8e-09 30.6 In-house 77-262 (284) alignment 
Range on Protein: 216-404
Range on HMM: 77-262/284.0
SPQSLESFWIMVASQKIQRLFILLgeeeldKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEqanTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTM
 . .|. || |.  ...  . .|       |   |.|.| . .. .     . ..| ..||     .    . .|  |     |    |  |||   | .
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveesee...yvvrdielsedgkekdirkirqfhflgwpdvgvpdy

GYNRIAATAA-SVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT---YGLKHV
. . ..     . ..|  .  |.  .    |.||.| . |    .....  .  .. ..   .| ||.  .. | ||.| |.  |    .|   |
psdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 157-398 7.1e-09 30.0 In-house 26-264 (283) alignment 
Range on Protein: 157-398
Range on HMM: 26-264/283.0
KCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIPS--VTTKSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFP
.... ..|  . . ...  .| .||.   |.  .   . ...       |  | ||  .    .    || ||  .||  . .|    |  .   | |.|
diasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld...rtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

E----DFKEFkTIRVNNRKTVPKTEEQANTqLYYE-VVPKDCAEAPFAMIEICDFWPDAKIPTM-GYNRIAATAASVFESDIDCDASCaivsnyGAGRAG
.    |. || |. ...  |      .  . | ..    .    | . .|.  .. ..| | ..  .|.. .      .. |    |       | ||..
krGsedyGef.tvtlrkettsnsfiikell.lrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCst......giGrta

SFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
 |  |. .......    .. ..   .| ||. |. || ||.. . ..| 
vfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 216-401 9.3e-09 30.0 In-house 113-295 (319) alignment 
Range on Protein: 216-401
Range on HMM: 113-295/319.0
SPQSLESFWIMVASQKIQRLFILLgeeeldKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEqanTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTM
 . .|. || |.  ...  . .|       |   |.|.| . .. .     . ..| .|.|     .    . .|  |     |    |  |||   |  
ldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae...yvvrdielsedgkekdirkitqfhflGwpdvGvpdy

GYNRIAATAA-SVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT---YGL
. . .      . ..|  .  |.  .    |.||.| . |    .....  .  .. ..   .| ||.  .. | ||.| |.  |    .| 
psdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 217-399 1e-08 29.4 In-house 101-282 (290) alignment 
Range on Protein: 217-399
Range on HMM: 101-282/290.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPED-FKEFKTIRVNNrktvpKTEEQ--ANTQLYYEVVPKDCAeAPFAMIEICDFwpdAKIPTM
.. |  || ..  .|.  . .|. . | .| .   |.|.   |..  ....        ||.    ..   ||  |. | ..  ..    .     ..  
sntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikl.....lneetlneyierklevknknsa.gakqsvtqyqi...tnwdst

GYNRIAATAASVFESDI-----DCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
|     .|  .|.|  .     . . |  .    . ||.. | .|  .|.| .     .. ..  | |.|.|  ..|  || . . | |||
gkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_PTPRG_pd Subfamily PTPRG 216-394 1.3e-08 28.5 In-house 100-281 (563) alignment 
Range on Protein: 216-394
Range on HMM: 100-281/563.0
SPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF-KEFKTIRVNNRKT---VPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIP
... .. || |.  |. . . ..   .|  .     |.|.|  .......|.  ..   .  |...   .       |.| .    .   .  |||   |
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvP

TMGYNRIAATAASvfESDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYV
.     .     |  .     .|   .|  ..|.||.| . |    ....|. .| |. ...  .|.||.  ..|  ||.| . 
ehslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhd
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 265-396 1.6e-08 28.5 In-house 196-332 (347) alignment 
Range on Protein: 265-396
Range on HMM: 196-332/347.0
VNNRK-TVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNRIAATAASVFESD------IDCDASCAIVSNYGAGRAGSFFVAVLAI
.| |. .| .   .   .   ||| . |.|| || .  |  ||  | |    . .|   | | ||       ..  |   .. . |  |. .  .. . |
intravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiii

EKLQAGEAPNIKEIALSVRSQRpAAIETLSQYmFTYVIA
|.. .| .|.  ..   .| || | . |.| . .|| | 
eqvldgktpdcddlfkkmrdqr.agvftmsif.ytyair
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 170-399 3.5e-08 27.0 In-house 49-275 (515) alignment 
Range on Protein: 170-399
Range on HMM: 49-275/515.0
SENVELYDTNRVKG-----GGEADFFYhGStlTIPSVTTKSTILAQLaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPE---DFKEFK
 .|.  ||..|||        . |.|   |   |||. .  . .|       . |.. || .|  ...  . ..   .| ||   ..|.|.   |  .| 
yknilPydsvrvklevindnPhsdyfn.as..yipsfdndkayiasq..gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

TIRVNNRKTVPKTEEQAnTQLyyEVVPKDCaEAPFAMIEICDfWPDAKIPTMgYNRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQ
.|.|.   .   |.     .|  .|.  |      .  .  . |||  .|    . .      |  .      .  |    |.||.| .  .   . . .
sikvelvsleactggik.rkl..tvlkgdd.srtvtqfhfte.WPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahak

AGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 ... .. ..   .| .||  . |  || | | . | .
ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 162-399 3.8e-08 27.8 In-house 47-283 (297) alignment 
Range on Protein: 162-399
Range on HMM: 47-283/297.0
KKNIDFS--QSENVELYDTNRVKGGG-----EADFFYhGStlTIPSVTTkSTILAQlaiVDSPQSLESFWIMVASQKIQRLFILLGEEELDKpTLSEYFP
.|...|.  . .|.  ||..|||        ..|..   |   ....     |  |      ..... || ||  .... . .|  ..| ||     |..
ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvn.as..fvkgnkh.rlittq...mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

ED-FKEFKTIRVNNRkTVPKTEEQANTQLyyEVVPKDCAEApfAMIEICDF--WPDAKIPTMGYNRIAATAASVFESDIDCDAS-CAIV-SNYGAGRAGS
..  ..| .. |    .| . |   . .|  ||   .       ...  .|  ||| ...     .      |  . | .  |.   .|    | ||.| 
dkgvttfGdvsvvll.svsereGfikrel..evtkgkakar..rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgv

FFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.      . . .  .. .| ..   .| .||  . |  || | ||. | .
lltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 139-401 6.1e-08 26.6 In-house 35-284 (290) alignment 
Range on Protein: 139-401
Range on HMM: 35-284/290.0
KTMEPeFKPIDTMKADL-EKCQAFKKNidfsQSENVELYDTNRV--KGGGEADFFyHGSTLtipSVTTKSTILAQLAIVDSpqsLESFWIMVASQKIQRL
... | . | . .. .. .|   ||||    .  .|   |  ||  | |.. |.  |   .     .    ||.| |. |.      .| ||  .|.  .
eklkp.ylpvqylerkifdkntefkkn....rykdvvcndktrvilkdGydGdyv.hanyv...kGlkamfiltqGalkdt...vidiwrmvlqekvaai

FILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYY-EVVPKDCAEAPFAMIEICDFWPDAKIPTMGYNrIAATAASVFESdidcDA
 .|    |  |.  ..|.||   |  |.         .....||...    |  ||              |||  ..      .  |  .. .       
vmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstla.llrtlrilrka....sG

SCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYGL
  ..    | ||.|.|     ... |  | . .. ..  ..|  | ....   ||.    | | .| 
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGk
0044763 (Phosphotyrosine protein) phosphatases II 214-391 8e-08 27.6 In-house 33-162 (178) alignment 
Range on Protein: 214-391
Range on HMM: 33-162/178.0
VDSPQslESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKefktirvnnrktvpkteeqantqlyyevvpkdcaeapfaMIEICDFWPDAKIPTm
 . |.  .... ..  ..|. .  | .| || .. . .|.||..                                        .  ..  .|| . |. 
gslpp..addlellkelgithivnlteelelgflkcdpywpeeag.......................................iqylhipipDhgvpd.

gYNRIAATAASVFESDI-DCDASCAIVSNYGAGRAGSFFVAVLAIEKlqageAPNIKEIALSVRSQRPaAIETLSQYMF
   ..   .    |. . ...  ...  ..| ||.|.. .| | ..        .. |.   ||..|| .... .|. .
.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrq
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 137-399 8.6e-08 26.2 In-house 17-275 (312) alignment 
Range on Protein: 137-399
Range on HMM: 17-275/312.0
FRKTMEPEFKPIDTMKADLEkCQAFKKNIDFSQSENVELYDTNRVKGGGEADFFYHGSTLTIpsvTTKST--ILAQLAIVdspQSLESFWIMVASQKIQR
  . .  |.| .  . .| | | || |  |. .  |.. .|  |    |. .|. |   . |    ||    . .| ..    ..   || .. |     
tpqqltkeykavgnivsdse.ctaflkfkdlnrypniqcwdrgrftlagdenfyihanfvki...ctkperfvctqgple...ntcthfwqlalslgsts

LFILLGEEELDKPTLSEYFPE--DFKEFKTIRVNNRKT-----VPKTEEQANTQLYYEVVPKDCAEAPFAMIEIcDFWPDAKIPTMgynriAATAASVFe
. .| |  |      ..|  .   | ...  ||            |. ..   ..   ||     |. .   .    |||  .|         ||  .. 
iillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqw.aswpdhgmpds.....cdtalrll.

SDIDCDASCAIV-SNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
| .  |    |     | ||.|.. .    |  |.     |.|.. . .| .|  ..... ||...  . | .
savkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 339-398 9e-08 26.3 In-house 234-293 (297) alignment 
Range on Protein: 339-398
Range on HMM: 234-293/297.0
VSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALT
    | ||.|    .   ..||. .  |... |   .|.||.  ..|| |. . | ..| 
hcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 204-396 9.2e-08 26.5 In-house 51-236 (239) alignment 
Range on Protein: 204-396
Range on HMM: 51-236/239.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVvpkDCAEAPFAMIEICD
|. | .| ..     |   || |.  ..   . .| |  |  |    .|.|.   ..  .||  |||   ..    | .  .|     .|  .       
kayiatqgcve...issgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhft

FWPDAKIPTMGYNRIAaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
 |||  .|      .      . .  .       |  . | ||.|.|.|    . . .  .. .| .   ..| .||  ..|  ||.| ..  
vwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 204-396 1e-07 26.4 In-house 52-237 (239) alignment 
Range on Protein: 204-396
Range on HMM: 52-237/239.0
KSTILAQLAIVdspQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKTIRVNNRKTVPKTEEQANTQLYYEVvpkDCAEAPFAMIEICD
|. | .| ..     |   || |.  ..   . .| |  |  |    .|.|.   ..  .||  |||   ..    | .  .|     .|  .       
kayiatqgcve...issgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqv...gqteeryvyqyhft

FWPDAKIPTMGYNRIAaTAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIA
 |||  .|      .      . .  .       |  . | ||.|.|.|    . . .  .. .| .   ..| .||  ..|  ||.| ..  
vwpdkgvpqyatavlg.lrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_PTPN6_pd Subfamily PTPN6 217-399 2.2e-07 25.1 In-house 108-296 (306) alignment 
Range on Protein: 217-399
Range on HMM: 108-296/306.0
PQSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFKEFKT--IRVNNRKTvPKTEEQANTQLYYEvvPKDCAEAPFAMIEI-CDFWPDAKIPTM
.. .. || ||  .. . . ..  | |  |   . |.|.  .. ..  |.|.| .   ....    .|  .   |. ..    ...     |||. .|. 
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvs..kkkkkkeerevfqyhfksWPdhgvpkd

GYNRIaATAASVFESDID---CDASCAIV-SNYGAGRAGSFFVAVLAIE---KLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
 .  . .    | .   .    .|   .|  . | || |.| |  . ..   |       .|...  |||.||   . | .|| | | .  .|
pgavL.dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
0049772 (Phosphotyrosine protein) phosphatases II 218-398 2.2e-07 26.4 In-house 155-278 (314) alignment 
Range on Protein: 218-398
Range on HMM: 155-278/314.0
QslesfwimvasqkiqrlfillgeeeldkptlSEYFPEDFKEFKtirvnnrktvpkteeqantqlyyEVV--PKDCAEAPFAMIEIcdFWPDAKIPTMGY
.                               .|. ..|....|                       |..  |... .. .  . |   .||   |.  .
g...............................neptaadlellk.......................eelydpelferlgikylri..pvpDgsaplled

nrIAATAASVFESdiDCDASCAIVSNYGAGRAGSFFVAVLAIEKLqaGEapNIKEIALSVRSQRP-----AAIETLSQYMFTYVIALT
  . .  . . |   | .   ..  . | ||.|.| || . . .|  |   ...|.   ||..||      .||.| || | . . | 
..fdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll..gv..sleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 213-399 3e-07 24.7 In-house 90-277 (287) alignment 
Range on Protein: 213-399
Range on HMM: 90-277/287.0
IVDSP--QSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDF----KEFKtIRVNNRKtvpKTEEQANTQLYYEVVPKDCAEAPFAMIEICDfWP
| .||  . .  || ..  .... . .|  |.| |.    .|.||.      |.. |.. |..   ....  . .|  .   |. ..      .| . |.
iaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyn.iellnee...vnagyierklevknknkagdkqqvkqyqitn.Wd

DAK-IPTmgYNRIAATAASVFES-DIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTY
.   ...  .. |       . .     ..|  .    . ||.. |  |  .|.| .   . .. ..  | | |.| .. | .||.| . | |.|
stgkvte..pqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 217-397 3.2e-07 24.2 In-house 101-276 (439) alignment 
Range on Protein: 217-397
Range on HMM: 101-276/439.0
PQSLESFWIMVASQKIQRLFILLGEEELDKptlseYFPEDFKEF---KTIRVNNRKTVPKTEEQAntqlYYEVVPKDCAEAPFAMIEIC-DFWPDAKIPT
 .. ..|| .|  .|  ..  |    |  |     |.| | . .    ..||.    .|.   .     .  .  .| .|   .....    ||| ..|.
kettddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirg....fkvfnerdttekertvlqfhyiawpdknvpa

MGYNRIAATAASvfESDIDCDASCA--IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVIAL
     .    |   .|  | .      .    | ||.|.     .|.|.|.. .  .|| |   .| ||   ...| ||.| |   |
qashvldflrai..nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 338-395 3.5e-07 24.5 In-house 197-254 (267) alignment 
Range on Protein: 338-395
Range on HMM: 197-254/267.0
IVSNYGAGRAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
.  . | ||.|.|.|.   .|...  .  .| .  . .||||.. ..|. .|.. . .
vacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihel
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 170-394 4.1e-07 24.4 In-house 9-233 (237) alignment 
Range on Protein: 170-394
Range on HMM: 9-233/237.0
SENVELYDTNRV--KGGGEADFFYHGSTLTIPSVTTKSTILAQLAIVDspqSLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDfKEFKTIRVNn
  |.  || .||  || | .  .   . |     | |. | ||  .     | . || ||  .|   . .| |  | ..    .|.|.  .. ..  |  
ygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgples...scddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvl.

RKTVPKTEEQANTQLYYEVVPKDCAEAPFAMIEICDF--WPDAKIPTMGYNRIAATAASVFESDIDCDASCAIVSN-YGAGRAGSFFVAVLAIEKLQAGE
  .. | || ..  .   .. |        .|   .|  |||  .|      .      . .|    ...  |.    | ||.| |.|    . . .  .
tvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekk

APNIKEIALSVRSQRPAAIETLSQYMFTYV
  .| .   |.  .||  |.|  ||.| . 
vvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 160-395 7.9e-07 23.5 In-house 44-283 (325) alignment 
Range on Protein: 160-395
Range on HMM: 44-283/325.0
AFKKNIDFSQSENVELYDTNRV-----KGGGEADFfYHGStlTIPSVTTKSTILAqlAIVDSPQSLESFWIMVASQKiQRLFILLGEEELDKPTLSEYFP
.  .|..  . .||  .| .||     |  ...|. .  |   . .   | . ||  | .  ..... .| .|   .   . ..| | .|.|   . |.|
mkpenkaknrfknvvaldksrvvletkkddpssdy.inas..ylrddkkkdvfla..aqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywp

ED---FKEFKTIRVNNRkTVPKTEEQANTQLYYEVVPKdcAEAPFAMIEICDFWPDA---KIPTMgYNRIAATAASVFESDID-CDASCAIV--SNYGAG
..    |.| ...|. | |. .  .    .|    | |   |.          |.|    | |.     |  .   | |     . ||  |.     | |
kemgksktfGglevklr.tieeisdyvhrvldvkqvkk..GetrsvkqfqlqswddmGvqkrpat.lisilqlvkavservtantkastpilvhcsaGvG

RAGSFFVAVLAIEKLQAGEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
|.| |     |..|.      .| .    .| .||. .||  ||.. |  
rtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyea
0051082 (Phosphotyrosine protein) phosphatases II 215-394 1.6e-06 23.4 In-house 19-147 (151) alignment 
Range on Protein: 215-394
Range on HMM: 19-147/151.0
DSPqsLESFWIMVASQKIQRLFILLGEEELDkpTLSEYFPEDFKEFKTIRVNNRKTVPkteeqantqlyyevvpkdcaeapfamieicdfwpdakiptmg
. |  |. |. ......|.  . | .||| .  .. ||.||   |.. | . . .. .                                          
ggp..ladflellkelgiktivnlrseeerg..ycpeylpelgievlhipildwpdpg..........................................

YNRIAATAASVFESDIDC-DASCAIVSNYGAGRAGSFFVAVLAIEKlqageaPNIKEIALSVRSQRPAAIETLSQYMFTYV
   . .......|  .|. .  ...  . | || | . ...| ...       .. |.   .|..|| .. .  |..| . 
lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 219-402 2e-06 21.7 In-house 93-271 (281) alignment 
Range on Protein: 219-402
Range on HMM: 93-271/281.0
SLESFWIMVASQKIQRLFILLGEEELDKPTLSEYFPEDFK---EFKTIRVNN-RKTVPKTEEQANTQLYYEvvpkdcAEAPFAMIEICDFWPDAKIPTMG
.   || |.  ..   . .|    | ..   .|||| . .   .|  . |.    || |.   .  .| ||       |. .    .   ||| ..|   
tradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye......getrlithwlwkewpdwqvpess

YNRIaataaSVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRS-QRPAAIETLSQYMFTYVIALTYGLK
   .      ..       .   |    | ||.|...   .|.. ...    |.||.|   .|   | |...|| |||. . . | .|. 
evml.....kilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
subfamily_CG42327_pd Subfamily CG42327 341-400 4.8e-06 20.5 In-house 255-315 (319) alignment 
Range on Protein: 341-400
Range on HMM: 255-315/319.0
NYGAGRAGSFFVAVLAIEKLQAG-EAPNIKEIALSVRSQRPAAIETLSQYMFTYVIALTYG
  |.||.|    . .||..|.   .. .| ..  ||| .|  |. |  || | | ..  | 
sdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
0048076 (Phosphotyrosine protein) phosphatases II 304-395 7.4e-06 21.2 In-house 54-138 (145) alignment 
Range on Protein: 304-395
Range on HMM: 54-138/145.0
FWPDAKIPTMGynRIAATAASVFESDIDCDASCAIVSNYGAGRAGSFFVAVLAIEklqagEAPNIKEIALSVRSQRPAAIETLSQYMFTYVI
 |||  .|..   ..  ..    |. .. .  ...  . | ||.|.. .| | ..     .  .. |.   |||||| |... .|. | |  
pwpDhgvpdll..ellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyef