Gene F42C5.5 in Caenorhabditis elegans

Synonym: CELE_F42C5.5, F42C5.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf3
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP082_AA protein Get Run
CeleP082_AA_30-303 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-3_pd Subfamily Cele-PTP-3 32-306 5e-199 651.2 In-house 1-275 (275) alignment 
Range on Protein: 32-306
Range on HMM: 1-275/275.0
QTTRGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFDEILDRENQEFFVHANTFRTPYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEE
|||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
qttrgketyqqdlddlnlddekierfirngeknrftnvtcfdeildrenqeffvhantfrtpygnflisqapndstnadhlhllwiynvqtvvclvlpee

AGGYFVPKEGETFTSFQKYQIKTIGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPRQQTVIMEYMWAFEETNAIENEVALADATTT
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||.||
aggyfvpkegetftsfqkyqiktigifdekqgvtvyqcelksykapkklnrrmvyiiccdtsvgsirsprqqtvimeymwafeeanaienevaladaktt

VLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFFSSVYTFFAFCVQSSAVSETN
||||.||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||.
vlvhaiagtrrcasfvvaavmckqlleagqfsametwfemrkrrahtctrkhdffssvytffafcvqssavsetd
0040438 (Phosphotyrosine protein) phosphatases II 35-305 4.5e-37 123.4 In-house 18-284 (317) alignment 
Range on Protein: 35-305
Range on HMM: 18-284/317.0
RGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFD------EILDRENQEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCL
.. .   .||....||. .. ..  |..|||.... ..|        |.  .   ...|.   .|    .|.. |.| ..| .|.....| ..|...|.|
talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmL

VLPEEAG-----GYFvPKegETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYkapKKLNRRMVYIICCDT-SVGSIR-SPRQQTVIMEYMWAFEEtnai
. .|| |      |. |   .... . ..........  ..|.|... |.. .   .. . |.|..... .   ...  ||..   ..|..... |    
teleelgrekcaqYw.pl..getltygdftvtllseee.lagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfleavreale....

enevalaDATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRaHTCTRKHDFFSSVYTFFAFCVQSSAVSET
       |  . ||||  ||  |...|..| .|. || ..|.... |.. |.|..| . .    ...  .|.. .. ..   ..| 
.......dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR.pgavqtpeqyrflydalleylkrkltlep
Y_phosphatase Protein-tyrosine phosphatase 60-285 2.2e-35 117.5 Pfam-A 1-226 (235) alignment 
Range on Protein: 60-285
Range on HMM: 1-226/235.0
NGEKNRFTNVTCFDEILDRE----NQEFFVHANTFRT--PYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEA----GGYFVPKEGETFTSFQK
| .|||.......|.   .     ... ...||. ..     .|...|.| .|| .|. ...| ..|...|.|.  ||       ...|.| |.......
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YQIKTI-GIFDEKQGVTVYQCELKSYKAPKklNRRMVYIICCDtSVGSIRSPRQQTVIMEYMWAFEETNaienevalADATTTVLVHGIAGTRRCASFVV
.....   . ......|....|||. |...  ..|.|. . .  .      |.... ........|...        .. .. |.|| .||. |...||.
ikvelkekekedekeytlrklelkkkkees..ekrevkqlhyt.nWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgtfva

AAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
. ....|| ...... .... |.||.|.. ... . .
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 60-285 2.2e-35 117.5 In-house 1-226 (235) alignment 
Range on Protein: 60-285
Range on HMM: 1-226/235.0
NGEKNRFTNVTCFDEILDRE----NQEFFVHANTFRT--PYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEA----GGYFVPKEGETFTSFQK
| .|||.......|.   .     ... ...||. ..     .|...|.| .|| .|. ...| ..|...|.|.  ||       ...|.| |.......
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YQIKTI-GIFDEKQGVTVYQCELKSYKAPKklNRRMVYIICCDtSVGSIRSPRQQTVIMEYMWAFEETNaienevalADATTTVLVHGIAGTRRCASFVV
.....   . ......|....|||. |...  ..|.|. . .  .      |.... ........|...        .. .. |.|| .||. |...||.
ikvelkekekedekeytlrklelkkkkees..ekrevkqlhyt.nWpdhgvpespkslldlirkveksk........eaksgpvvVhCsaGvgRtgtfva

AAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
. ....|| ...... .... |.||.|.. ... . .
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
0036941 (Phosphotyrosine protein) phosphatases II 34-297 6.7e-35 116.2 In-house 13-277 (297) alignment 
Range on Protein: 34-297
Range on HMM: 13-277/297.0
TRGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFDE---ILdRENQEFFVHANTFRTPY--GNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVL
.. .. ... |. ..| . .. .. .| ||||.... ..|    .|  ..   ...|.   ...   .|.. |.| ..| .|. ...| .||...|.|. 
alllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte

PEEAGG-----YFVPKEGETFTsFQKYQIKTIGIFD-EKQGVTVYQCELKSYKAPkklNRRMVYIICCDTSVgSIRSPRQQTVIMEYMWAFEETNAIEne
..| |      |. ..|||..| . .........   .....|....|.. .. .   . |.|..... .       |   . .......... ..    
lvelgrekcaqywpleegeslt.ygdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwp.dhgvpespaslldfielvrkvlkll..

valaDATTTVLVHGIAGTRRCASFVVAAVMCKQLL---ETGQFSAMETWFEMRKRRAHtCTRKHDFFSSVYTFFAFCV
       . ||||  ||  |...|..| .|. ||    ..|...  |.. ..|..|.. .    ...  .| .... .
....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg.avqtleqyrflyeallell
0050432 (Phosphotyrosine protein) phosphatases II 31-283 2.7e-33 111.0 In-house 39-286 (308) alignment 
Range on Protein: 31-283
Range on HMM: 39-286/308.0
LQTTRGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFDE---ILdrENQEFFVHANTFRTP----YGNFLISQAPNDSTNADHLHLMWIYNVQTV
|.... .| ... |.  .| . .. .. .|..|||.... ..|    .|  ..   ...|.  ...       |.. |.| ..| .|. ...| .||...
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

VCLVLPEEAGG-----YFVPKEGETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPKKlnrRMVYIICCDTSVgSIRSPRQQTVIMEYMWAFEETNa
|.|  ..| |      |. ...|.... . |...... .   ....||.. ||. .. ..    |.|..... .       | . . ....... .... 
vmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdges...rtvthfhytnWp.dhgvPpspeilldflelvrksl.

iENevaladatTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKH
 ..         ...||  ||  |.. |... ... || ..| ... |..  .|..|..  . . 
.pg........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0043336 (Phosphotyrosine protein) phosphatases II 35-293 4.1e-33 110.4 In-house 20-273 (278) alignment 
Range on Protein: 35-293
Range on HMM: 20-273/278.0
RGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFD------EILDRENQEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCL
.. .   ..|....||. .| ... |..|||.... ..|      . |. ..   ...|..  ..    .|...|.|...| .|. ...| ..|.|.|.|
tllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmL

VLPEEAGG----YFVPkegETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPKKlnrRMVYIICCDTSVgSIRSPRQQTVIMEYMWAFEETNAiene
. ..| |     .. |   .... . .........   ....||.. |.. .. ...   |.|.....         | . . ......|. | ..    
telvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdges...rtvthyhylgwp.dhgvpeslsllldflkavreale....

valaDATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRaHTCTRKHDFFSSVYTFF
    |  . ||||  ||  |.. |... ... ||  .| ... |.. |.|..| . .    ...  .| . 
....dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR.pgavqtpsqyrflyeal
0047943 (Phosphotyrosine protein) phosphatases II 33-291 8.6e-33 109.4 In-house 11-266 (273) alignment 
Range on Protein: 33-291
Range on HMM: 11-266/273.0
TTRGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFDE---ILdRENQEFFVHANTFRTPYG--NFLISQAPNDSTNADHLHLMWIYNVQTVVCLV
.|. .| ... |.  .| . .. ....|..|||.... ..|    .|  ..   ...|.  ....   .|.. |.| ..| .|.....| .||...|.|.
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLt

LPEEAGG-----YFVPKEGETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPKklnRRMVYIICCDTSVgSIRSPRQQTVIMEYMWAFEETNAI--E
 ..| |      |. ...||... . |.........  |...||.. ||.... ..    |.|..... .       | . . ..|.... .....   .
elvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge...srtvthfhytgwp.dhgvppslesllefielvrkalealps

NevaladatTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHtCTRKHDFFSSVYT
|        ..|.||  ||  | ..|... ... || ..|.... |..  .|..| . .    ...  .| 
n........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpg.mvqtpeqyrflye
0039614 (Phosphotyrosine protein) phosphatases II 41-290 1.3e-32 108.8 In-house 38-282 (297) alignment 
Range on Protein: 41-290
Range on HMM: 38-282/297.0
QQDLDDMNLDdEKIERFIRNGEKNRFTNVTCFDE-------ILDRENQEFFVHANTFRTPYG---NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPE
 ..| ... |  .| ... |..|||.... ..|        . .. .   ...|.   ...    .|...|.|...| .|.....| ..|...|.|  ..
feellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklv

EAG----GYFVPKEGetftSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPkklnrRMVYIICCDTSVgSIRSPRQQTVIMEYMWAFEETNAIEnevala
| |     |. ...|     . ..........  ..|.||.. |.. .. .     |.|. ...         |   ....| . . .| .|        
elgrkcaqywpeegg....tygdftvtllkveh.ldgytvrtlevtnnges.....rtvthfqytgwp.dhgvppslellleflelvrealael......

DATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRkHDFFSSVY
.  . ||||  ||  |...|..|  |. || ..|.... |.. |.|..| . ..   ...  .|
pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt.psqyrfly
0040439 (Phosphotyrosine protein) phosphatases II 53-293 1.5e-30 102.0 In-house 4-242 (249) alignment 
Range on Protein: 53-293
Range on HMM: 4-242/249.0
KIERFIRNGEKNRFTNVTCFD------EILDRENQEFFVHANTFRTPY--GNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAG----GYFVPKe
.. ..  |..|||.... ..|      .||.  .   ...|. . ..|   .|.. |.| ..| .|.....| ......|.|  ..| |      . |  
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

gETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMVYIICCDtSVGSIRSPRQQTVIMEYMWAFEETNaienevalaDATTTVLVHGIAGT
 .... . ....... .   |...||.. ||. .. ....  . .... .    |   |. .   ..|... . |..         .  . ||||  || 
.ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleel.........pkggpvlVHCsaGv

RRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHtCTRKHDFFSSVYTFF
 |.. |..|  |. || ....... |.. ..|..| . .    ...  .| . 
gRtGtfiaaylmleqlekelgvdleeavkllrsqRpg.avqnpeqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 44-290 2.2e-30 101.9 In-house 39-297 (307) alignment 
Range on Protein: 44-290
Range on HMM: 39-297/307.0
LDDMNLDDEKIERFIRNGEKNRFTNVTCFDEILDRE-------NQEFFVHANTFRTPYG----------NFLISQAPNDSTNADHLHLMWIYNVQTVVCL
. .. |.. .| ..  |..|||.... ..|    .        .   ...|.  |.|..          .|.. |.| ..| .|.....| ..|...|.|
vtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivml

VLPEEAGG----YFVPKEgETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYkAPKKLNRRMVYIIC-CDTSVGSIRSPRQQTVIMEYMWAFEETnaien
  ..| |      . | | ...  . .........   ..|.||.. |.. .  ...  |.  .... .    |   |. .   ..|..... |.     
telvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee.....

evalADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQ---FSAMETWFEMRKRRAHTCTrKHDFFSSVY
     .  . ||||  ||  |...|..| .|..|| ..|    ... |.. ..|..| . ..   ...  .|
....lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq.npeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 34-282 2.6e-30 101.3 In-house 23-272 (288) alignment 
Range on Protein: 34-282
Range on HMM: 23-272/288.0
TRGKETYQQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFDEI------LDRENQEFFVHANTFRTPYGN--FLISQAPNDSTNADHLHLMWIYNVQTVVC
|. .| ... |.     . .. ..  | ||||.... ..|        || ..   ...|.  .... .  |.. |.| ..| .|. ...| .||...|.
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvm

LVLPEEAG----GYFVPKegETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPRQQTVIMEYMWAFEETNAien
|  ..| |     .. |   .... . ....... .   ....||.. |.. .. ... .    ... . |.      |   . ..... .. . .|   
ltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...

evalaDATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRK
     .   .|.||  ||  |.. |... ... ||...| ....|..  .|..| . ..  
.....sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
DSPc_SM00195 44-296 3.4e-29 97.3 In-house 9-261 (263) alignment 
Range on Protein: 44-296
Range on HMM: 9-261/263.0
LDDMNLD-DEKIERFIRNGEKNRFTNVTCFDEI---LDREN---QEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEA--
|.... . . . ... .| .|||..|. ..|.    |..|.   .. ...||  ...    .. . |.| .|| .|. ...|  .|...|.|. .||   
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

--GGYFVPKEGETFTSFQKYQIKTIGIFDEKQGVTVYQCELKSYKApkkLNRRMVYIICCDTSVGSiRSPRQQTVIMEYMWAFEETNAIEnevaladaTT
     ..|.| .. . |.|...|..    .|. ..... ||.  .     . | |. . . .   .   | ... ..|.. |.....  .        ..
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts........sg

TVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHtCTRKHDFFSSVYTFFAFC
...||  ||  |...||.. .....| |. ...  |.. |.|| |.. . ....... .|. ....
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfiyeailey
PTPc_SM00194 44-296 3.4e-29 97.3 In-house 9-261 (263) alignment 
Range on Protein: 44-296
Range on HMM: 9-261/263.0
LDDMNLD-DEKIERFIRNGEKNRFTNVTCFDEI---LDREN---QEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEA--
|.... . . . ... .| .|||..|. ..|.    |..|.   .. ...||  ...    .. . |.| .|| .|. ...|  .|...|.|. .||   
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

--GGYFVPKEGETFTSFQKYQIKTIGIFDEKQGVTVYQCELKSYKApkkLNRRMVYIICCDTSVGSiRSPRQQTVIMEYMWAFEETNAIEnevaladaTT
     ..|.| .. . |.|...|..    .|. ..... ||.  .     . | |. . . .   .   | ... ..|.. |.....  .        ..
ekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts........sg

TVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHtCTRKHDFFSSVYTFFAFC
...||  ||  |...||.. .....| |. ...  |.. |.|| |.. . ....... .|. ....
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpg.mvqtleqYlfiyeailey
0042113 (Phosphotyrosine protein) phosphatases II 54-281 9.6e-29 95.9 In-house 3-228 (245) alignment 
Range on Protein: 54-281
Range on HMM: 3-228/245.0
IERFIRNGEKNRFTNVTCFD------EILDRENQEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGG----YFVPKeg
. ... |..|||.... ..|         . ..   ...|.   ..  ...|...|.| ..| .|.....| ....|.|.|  .|| |      . |   
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

ETFTSFQKYQIKTIGIFDeKQGVTVYQCELKS-YKAPKKLNRRMVYIICCDTSVGSIRSPRQQTvimeymwafeeTNAIEN---EvalaDATTTVLVHGI
.... . .........   ....||.. |..  .. ... .... |. . | .| .. .  ..             .....   |    |. ..||||  
gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldf...........lefvrkalae....dsngpvlVHCs

AGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTR
||  |.. |..|  |. || ... .|. |.  |.|..| . .. 
aGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqt
0046845 (Phosphotyrosine protein) phosphatases II 51-293 4.4e-27 90.6 In-house 19-270 (284) alignment 
Range on Protein: 51-293
Range on HMM: 19-270/284.0
DEKIERFIRNGEKNRFTNVTCFDEI-------LDRENQEFFVHANTFRTP-------YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAG---
. .. ..  | .|||.... ..|          .. .   ...|.  ...         .|.. |.| ..| .|. ...| .||...|.|  ..| |   
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

-GYFVPKEgETFTSFQKYQIKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPRQQTVIMEYMWAFEETnaienevalADATTTV
  .. | | ...  . ....... .   |...||.  ||. .. ...  . ... .      |   ||..   .....  . |           .   ..
caqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.........lpgggpi

LVHGIAGTRRCASFVVAAVMCKQLLETG---QFSAMETWFEMRKRRAHtCTRKHDFFSSVYTFF
.||  ||  | . |... ....|| ..|    ... |..  .|..| . .    . .  || ..
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg.mvqtleqyrfvyeal
0045098 (Phosphotyrosine protein) phosphatases II 47-292 3.1e-24 81.3 In-house 20-267 (278) alignment 
Range on Protein: 47-292
Range on HMM: 20-267/278.0
MNLDDEKIERFIRNGEKNRFTNVTCFDEILDRenqEfFVHANTFRTPYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAG-----GYFVPkeg
 . ..     .. |..|||.... ..|    .   . ...|.  ...  .|.. |.| .|| ||.....| ......|.|   .| |      |. .   
gipseitpalylgnldknRykdilpydhsrVk...d.YINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe...

ETFTSFQKYQIKTIGIFDEkQGVTVYQCELKS-YKAPKKLNRRMVYIICC-DTSVGSIRSPRQQTVIMEYMWAFEETNA-----IENEVALADATTTVLV
. .  . ....... .    . .|.   ..   .  .. |  | |.....     ... |    . . |..   .| ..     .. .. | |  ..|||
ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HGIAGTRRCASFVVAAVMCKQLlEtGQFSAMETWFEMRKRRAHTCTRKHDFFSSVYTF
|  ||  | . .|.|  |...| | |.... |.  |.|..| ...    ...  .| |
HCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyef
0037934 (Phosphotyrosine protein) phosphatases II 56-292 1.7e-21 72.4 In-house 6-237 (243) alignment 
Range on Protein: 56-292
Range on HMM: 6-237/243.0
RFIRNGEKNRFTNVTCFDEILDRENQEFFVHANTFRTPyGNFLISQAPNDSTNAD----HLHLMWIYNVQTVVCLVLPEEAGGY----FVPkeGETftSF
... | .|||.... ..|    . . . ...||  . . ... ..|.| ..| .|    .....| ......|.|  ..| | .    . |  ||.   .
llpenlsknrysdilpydhsrvklegsdyinanliyvt.prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev..ty

QKYQIKTIGIFDeKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPRQQTVIMEYMWAFEETNAienEVALADATTTVLVHGIAGTRRCASFV
 .........   ....||.  .|. .....     . |   .    |   || .   .......| |       .  .|   .||||  ||  | . ..
gdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell...sllaldsggpvlVHCsaGvgRtGtli

VAAVMCKQLletgQFSAMETWFEMRKRRAHTCTRKHDFFSSVYTF
.| .|...|    .... |.. ..|..| . .    ...  .| .
aaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 54-287 8.7e-17 57.3 In-house 40-264 (314) alignment 
Range on Protein: 54-287
Range on HMM: 40-264/314.0
IERFIRNGEKNRFTNVTCFDE-----ILDRENQEfFVHANTFRTPyGNFLISQAPNDSTNADH----------LHLM--WIYNVQTVVC-----------
. .. .| .|||.... ..|       |. ..   . .|. ....  .|...|.|.. |  |           ....  . .|| ..|.           
vadlflnrdknryldilpadnrvilpglpvsgsd.yinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladels

----------LVLPEEAGGYFVPKEGETFTsfqkyQIKTIGIFDEKQGVTVYQCELKSYKAPkkL--NrrmvyiiccdtsvgsirsprqqtvimeymwaF
          |  . . |.. .... |..      .. . . . |..|...... .  . ||  |                                  |
rLdaAlgKtpllildgngneptaadlellk.....eelydpelferlgikylripvpDgsap..lled...............................f

EETNAIENEValaDATTTVLVHGIAGTRRCASFVVAAVMCKQLletgQFSAMETWFEMRKRRAhtCTRKHDFFS
.|  .. .|.   |. . ||||  ||  | ..||||| ..|.|    ..|. |.. ..|..|   .  .. |. 
deflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRp..inpnpgfie
0041856 (Phosphotyrosine protein) phosphatases II 60-294 2.1e-16 55.5 In-house 1-169 (182) alignment 
Range on Protein: 60-294
Range on HMM: 1-169/182.0
NGEKNRFTNVTCFDEILdrenQEFFVHANTFRTPYGN--FLISQAPNDSTNADHLHLMWIYNVQTVVCLVlpeeaggyF----Vpkegetftsfqkyqik
| .|||.... ..|  .       ...|| .. .. .  |.. |.| .|| ||.|.... ....|.|.|                               
nldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp................

tigifdekqgvtvyqcelksyKAPKKLNRRMVYIICCDTSVGSirsprqQTVIMEYMWAFEEtnaienevaladATTTVLVHGIAGTRRCASFVVAAVMC
                     .  ..|. . .|. . | .| .         . ... . .|               .||||  ||  | ...|.| .|.
.....................ellerlgiqylylpwpDhgvpd......ldelldfieevle............eggpvlVHCsaGvgRtgtlvaaylmk

KQlletgQFSAMETWFEMRKRRAHTCTRKHDFFSSVYTFFA
|.     ..|. |.. ..|.|| . ... . .|   .  . 
kl.....gvsleeavklvrsrRpgmvitpnqyfflqlalle
PTPc_DSPc_SM00012 199-288 1.1e-13 46.7 In-house 15-99 (105) alignment 
Range on Protein: 199-288
Range on HMM: 15-99/105.0
SPRQQTVIMEYMWAFEETNAIENEvaladaTTTVLVHGIAGTRRCASFVVAAVMCKQLLET-GQFSAMETWFEMRKRRAHTCTRKHDFFSS
 |.... |.|...|... .  ...      .. |.||  ||  |.. ||.......|| .. ....  ... |.||.|...........  
vPeesdsilellravkknknkses......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 30-300 1e-11 38.8 In-house 22-288 (302) alignment 
Range on Protein: 30-300
Range on HMM: 22-288/302.0
HLQTTRGKETYqQDLDDMNLDDEKIERFIRNGEKNRFTNVTCFDEIL--DRENQEFFVHANTFRTP--YGNFLISQAPNDSTN---ADHLHLMWIYNVQT
.|.|.. |... . .| |  | || . | .| .||. ..| . |. |    ......|.| .   |    . ...| |. ...   ..  ....  ....
sldtaevkkef.kkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVCLVLPEEAGG---YFVPKEGETFTSFQKYQIKTIGIFDEKQGVTVYQCELksykAPKKLNRRMVyiiCcdtSVGSIRSPRQQTVIMEYMWAFEETNAI
|| || .||       . ||. .... ..|  . .  .   .. .| |  |.     |.     ..   .   .|  .   .|..| ..|  . ..   .
vvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEv....lPegcsnsvl...a...nvyvltnWkqkkvpvkyaeliktaakv

enEVALADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDfFSSVYTFFAFCVQSS
   .  ..|. ....    |. | ..|...||  ..| .  .  . |.   .|. |...    .  . |.|  ... ..  
..fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQ.yvslyialllyikkk
0044763 (Phosphotyrosine protein) phosphatases II 95-283 2.1e-11 39.3 In-house 28-158 (178) alignment 
Range on Protein: 95-283
Range on HMM: 28-158/178.0
GNFLISQAPNdstnADHLHLMWIYNVQTVVCLVLPEEA-----GGYFVPKEGetftsfqkyqiktigifdekqgvtvyqcelksykapkklnRRMVYIIC
........|.    ||.| |.. ......|.|  . |        |.. ..|                                         ....| .
pglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag........................................iqylhipi

CDTSVGSIRSPRQQTVimEYMWAFEetnaienevalADATTTVLVHGIAGTRRCASFVVAAVMCKQlletgQFSAMETWFEMRKRRAhTCTRKH
 | .| ....  ...|  |.. ..            ..   .||||  ||  | ...|.|  |.|.     ..|. | . ..|.||   ... .
pDhgvpdllehflefv..efieeal...........dekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 43-282 7e-11 36.7 In-house 29-265 (288) alignment 
Range on Protein: 43-282
Range on HMM: 29-265/288.0
DLDDMNLD-DEKIERFIRNGEKNRFTNVTCFDEI------LDRENQEFFVHANTFRTPYG--NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLP----
 |  .. . .... |  .| .|||. |.  .||       |. |... .. |. .    .  ... .|.|. .|  |  .|.. ....|.| |       
sLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelvegg

EEAGGYFVPKEGeTFTSFQKYQIKTIGIFDEKQgvtVYQCELKSYKAPKKLN-RRMVYIICCDTSVgsirsPRQQTVIMEYMWAFEETNAIEnevalada
..  . . |... . . . . ... ..  ....   . . .|   |  ..|.  .. | .  |..|     |.... ..|..   . .|  .        
ktkCeeYWPdad.kpknyGsvtvtlveskeled...fvlrklllekkkteleitqyqylaWpdhgv.....Peskapllellrqvkvanqad........

TTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRK
|  ..||  ||  |   |...  . ... |. .   ..|  ..||.||     .
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtl
0043147 (Phosphotyrosine protein) phosphatases II 94-280 1.6e-10 36.5 In-house 17-145 (172) alignment 
Range on Protein: 94-280
Range on HMM: 17-145/172.0
Y--GNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVlPEeaggyfvpkegetftsfqkyqiktigifdekqgvtvyqceLKSYKAPKKLNRRMVYIICCD
|   .|.. |.| ..| ||...... ......|.|  ..                                        |. ..  ..|. .  |. . |
yipdrfiatqgplrntladfwrmlkelgithivnlt.el........................................lydpellerlgiqylylpwpD

TSVGsIrsprqqtvimeyMWAFEETNAIENEVALADATTTVLVHGIAGTRRCASFVVAAVMCkqlletGQFSAMETWFEMRKRRAHTCT
 .|  .            .  ..|.  . .|... .   .||||  ||  | . .|.|  |.       ..|. |.  ..|..| . ..
hgvp.l............lellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq
0049260 (Phosphotyrosine protein) phosphatases II 97-280 1.9e-10 36.1 In-house 11-134 (152) alignment 
Range on Protein: 97-280
Range on HMM: 11-134/152.0
FLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGYFVPKEGetftsfqkyqiktigifdekqgvtvyqcelksykapkklnrRMVYIICCDTSVGS
|.. |.| . | ||...... ....|.|.|  ..| | .....                                           .  .. . | .| .
fiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.........................................qylhlpwpDhgvpd

IRSPRQQTVIMEYMWAFEETNaienevaladattTVLVHGIAGTRRCASFVVAAVMCkqlletGQFSAMETWFEMRKRRAHTCT
.    .. ...   .| .. .             .||||  ||  | . .|.|  |.       ..|. |.   .|..| . ..
lsqlllflllfieklaldkgg.............pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavp
subfamily_PTPN12_pd Subfamily PTPN12 59-299 2.2e-10 34.9 In-house 39-279 (290) alignment 
Range on Protein: 59-299
Range on HMM: 39-279/290.0
RNGEKNRFTNVTCFDEI---L---DRENQEFFVHANTFRTPYGN--FLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAG----GYFVPKEGETFTS
.| .|||. ..  .|.    |   . |... .. ||  . ..|.  .. .|.|   |  |. ...| .||. || .    | |      . |.|||. . 
envkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele

FQKYQIKTIGIFDEKQGVTVYQCELKSYKAPKKLNrRMVYIICCDTSVgsirsPRQQTVIMEYMWAFEETNAienevalaDATTTVLVHGIAGTRRCASF
|........     ... .. . ...  |. .|.. .. |    |  |     |.... ..| .....|..         .  . ..||  ||  |    
fgefevtleeekavdddflirtLkveaqkesrkvy.qfhYtaWPDhgv.....Pssaksllelielvrelqe........sedaPlvvhCsaGvGrtGti

VVAAVMCKQLLET---GQFSAMETWFEMRKRRAHTcTRKHDFFSSVYTFFAFCVQS
..   . ..| .     ...  .   |.||.||    . .. .. ||   |  ||.
iaidyvrellkaekipeeldvfdlvlelrkqraal.vqtkeqyelvykavaelvqk
0046846 (Phosphotyrosine protein) phosphatases II 84-282 3.6e-10 35.4 In-house 14-158 (176) alignment 
Range on Protein: 84-282
Range on HMM: 14-158/176.0
FVHANTFRTPYgnFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGYFVPKEGETFTSFQKyqiktigifdekqgvtvyqcelksykapkklnrr
...|| . ...  ... |.|  .| || |.... .....||.|  . | | . .|   . .....                                   
yinanlilgsr..piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..................................

mvyiiccdtsvgsirsprqqtV----IMEYMWAFEEtNAIENEVALADAT----TTVLVHGIAGTRRCASFVVAAVMCKQlletGQFSAMETWFEMRKRR
                           .. ... .  ..... ... .       .||||  ||  | . .|.|  ....     ..|. |.  ..|..|
.....................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllele....kglsveealalvreqR

AHTCTRK
 . .   
plgavqt
subfamily_PTPN9_pd Subfamily PTPN9 53-295 4.9e-10 33.9 In-house 35-289 (297) alignment 
Range on Protein: 53-295
Range on HMM: 35-289/297.0
KIERFIRNGEKNRFTNVTCFDE------ILDRENQEFFVHANtFRTPY---GNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAG----GYFVPK
.  .   | ||||.|.| |.||       .| ...  ...|| |   |     |.  | | . |  |.  ..|  .| ..|     .| |    | . |.
lasklranleknrytdvlcydetrvvlakvdedeasdyinan.fvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl

EGETFTSFQKYQIKTIGIFDEKQgVTVYQCELKSYKapKKLNRRMV-YIIccdTSVGSIRSPRQQTVIMEYMWAFEETNA-----IENEVALADATTTVL
| |. ..| ....... .  |..  .| . |.|  |  .. .|... . .   .|      |.. . ... . .  |. |     . .| .       ..
eeessaefgdlsvsnveveeeed.ykvrvleiknvk..teesrkvthfqf...lsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPiv

VHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFFSSVYTFFAF
||  ||  |   |.   .  ..| |.|.   .||   .|..||..    . .     .   .
vhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavley
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 46-286 6.2e-10 33.8 In-house 42-280 (298) alignment 
Range on Protein: 46-286
Range on HMM: 42-280/298.0
DMNLDDEKIERFIRNGEKNRFTNVTCFD---EILDR----ENQEF----FVHANTFRTpygNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGG
... .  .. |  .| .|||....  .|    .| .    |. ..    |.|| . |.    |...|||  .| .|  .... ....|.| |   || . 
eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn...afiatqaPltetvedFWrmvteedigtiVmltnleeldk

----YFVPKEGETftsfqKYQIKTIGIFDEKQGVTVYQCELKSYKAPKKlNRRMVYIICCdTSVGSIRSPRQQTVIMEYMWAFEEtNAIENevaladATT
     . |.||..     .|   |. .  ...   . ...||  |. .. ..|.|  .   ||  .   |...| .....   .  .  ..        .
tkyhkywPdegke.....tygeitvsllskeefadlivrklkvskkkee.kerevrqlhf.tsWpdkgvpenatsvldllrkvra.sqqqa......gnk

TVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFF
 |.|.  ||. |  .|..   .  .. .      ...   .||.|... . .... 
pvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYv
subfamily_PTPN23_pd Subfamily PTPN23 59-284 1.1e-09 32.5 In-house 42-268 (288) alignment 
Range on Protein: 59-284
Range on HMM: 42-268/288.0
RNGEKNRFTNVTCFDE--ILDRENQEFFVHANTFR--TPY-GNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGY----FVPKEGETFTSFQK
.. ||||....  .|.  .  |.... .. |   .  .|.  .|...||| .|| .|   ...   ....|.|. .|| |      . |.. .  ..|..
lyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd

YQIktiGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIicCDTSVGSIRSPRQQTVIMEYMWAFEET-NAIENEVALadattTVLVHGIAGTRRCASFVV
...    . ....  |. . .||    ...  . ....    ||  ..  |    ...... . |.. .| ....        ..||  ||  |   | .
lsv...tlksvretethvervlkletldadavksvshl..qltsWpelGvPasPetllqfldevesayeavqrkskt.....PlvvhCsaGvgRtgvfal

AAVMCKQL-LETGQFSAMETWFEMRKRRAHTCTRKHD
     ..|  . |    .. .  .|. | .    |. 
vyaavrelekgnglldiiqvvsrlreqRrfmvqekeq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 53-285 1.4e-09 32.8 In-house 18-244 (284) alignment 
Range on Protein: 53-285
Range on HMM: 18-244/284.0
KIERFIRNGEKNRFTNVTCFDEI---LDRE-NQEFFVHAN-TFRTPYG---NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVlpEEAGGYFVPKEGETf
.     .| .|||....  ||.    |.|   .||  . | .| | |     .. .| | | | ||   ..| ||. |.| |   ..    . |....  
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..kdkcsqywplkivi.

tSFQKYQIKtIGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPrqqTVIMEYMwafEETNAIENEvalADATTTVLVHGIAGTRRCA
   .....| .   .| .  .| . ||      |.  .   . .     ||   .|   . .|  .   .  . ...     .  ....||  ||. |  
.keerfkvk.vdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp...sdlmrlv...kkvrhltsk...enhranivvhcsagvgrtg

SFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
 ..|  |. ... |  |   ...  ..|..| .      ..
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_PTPN14_pd Subfamily PTPN14 58-277 1.5e-09 32.3 In-house 47-277 (300) alignment 
Range on Protein: 58-277
Range on HMM: 47-277/300.0
IRNGEKNRFTNVTCFDEI-----LDRENQEFFVHANTFRTPYG----NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGG----YFVPKEGETF
  | ||||| .|  ...        .||.. .. | . ... |    .....|.| . |  |. ...|  .|| .| |   || |      ..||...  
penaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskk

--TSFQKYQIKTigIFDEKQGVTVYqCELKSYKAPKKLNRRMVYIICCDTSvgSIRSPRQQTVIMEYMWAFEETNAIENEVA-LADATTTVLVHGIAGTR
    |.|... |   | |. . ..    || .  | | .| ....   | .    . |.  .  ..|.  ..      |.     ..   ||||  ||  
ktvefgkfkvtt..kfsedsdsvit.tglklkhlpskeertvwhlqytDWp..dhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvG

RCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAH
|    ... .. . |    .    ..   .|..| .
rtGvlilsdlliatlehneeidikkvlarLreqrml
0051429 (Phosphotyrosine protein) phosphatases II 92-281 1.8e-09 33.1 In-house 19-210 (272) alignment 
Range on Protein: 92-281
Range on HMM: 19-210/272.0
TPYGNFLISQAPNDSTNADHLHLmWIYNVQTVVCLVLPEEAGGYFVPKEGetftsfQKYQIKTIGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCd
.  | .. |..| . | ||  .| . ... |.|.|  .|| | . ....       .  ..  . |.|.      | .    .   . |.  ... ..  
vkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw......pgirylhlpilddsaptilygalrvtllseellldyilrelll.

TSVGSIRSPRQQTVIMEYMWAFEET--NAIENEVALADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFS--------AMETWFEMRKRRAHTCTR
| . |   .|. .... . | .  .  .|. . ..|  .   ||||  ||  | . .|..  .  .. ..  .         . |.. |.|..|..    
tlllsagearevmhlhytdwpdhgvpqeallellellldggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 47-285 2.8e-09 31.7 In-house 48-280 (319) alignment 
Range on Protein: 47-285
Range on HMM: 48-280/319.0
MNLDDEKIERFIRNGEKNRFTNVTCFDEI---LDRE-NQEFFVHAN-TFRTPYG---NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVlpEEAGGYFVP
.|| | .     .| .|||..|.  ||.    |.|   .||  . | .| | |     .. .| | | | ||   ..| ||. |.| |   ..    . |
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt..kdkcsqywp

KEGETftSFQKYQIKtIGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPrqqTVIMEYMwafEETNAIENEvalADATTTVLVHGIA
....     .....| .   .| .  .| . ||      |   .   . .     ||   .|   . .|  .   .  . ...     .  . ..||  |
lkivi..keerfkvk.vdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp...sdlmrlv...kkvrhltsk...enhranivvhcsa

GTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
|. |   ..|  |. ... |  |    ..  ..|..| .      ..
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 59-297 5e-09 30.7 In-house 47-288 (325) alignment 
Range on Protein: 59-297
Range on HMM: 47-288/325.0
RNGEKNRFTNVTCFDE------ILDRENQEFFVHANTFRTPYG--NFLISQAPNDSTNADHLHLM--WIYNVQTVV-CLVLPEEAGGYFVPKEGETFTSF
 | .|||| ||  .|.       .. . .  .. |. .|.  .   || .|||. .|  |   |.  |   |  |.  | | ..    . |||      |
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktf

QKYQIKTIGIFDEkQGVTVYQCELKSYKAPKKLNRRMVYIICCDtSVGSirsPRQQTVIMEYMWAFeetNAIENEVAL-ADATTTVLVHGIAGTRRCASF
   ..| . | .        . ..|  |  . .  .   .   |  .|    ... . .. ..      .|... |   . |.| .||| .||  |.  |
Gglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswd.dmGv...qkrpatlisilqlv...kavservtantkastpilvhcsaGvGrtGvf

VVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCtRKHDFFSSVYTFFAFCV
.    . ....|  .   ..    .|| |     .  | .. .|. ..  .
islysalakvieesrvdifgfvkklrkdrpsmv.etvdqyiliyealveay
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 51-285 1e-08 29.6 In-house 39-272 (319) alignment 
Range on Protein: 51-285
Range on HMM: 39-272/319.0
DEKIERFIRNGEKNRFTNVTCFDEI------LDRENQEFFVHANTFRT--PYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGYFVPKEgE
. .     .| .|||..|.  .|        ||  ..  .. |.   .     .|.  ||| . |  |   ..| ... .|| |    | .  .. |   
tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkky.w

TFTSFQKYQIKTIGIFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCdTSVGSIRSPRQQTVIMEYMwafeetNAIENEVALAdATTTVLVHGIAGTRR
. . |..|   .. . .|..   .   .||  |.  ... |.|      |.      |.. | ... .      . |.. .        . ||  ||  |
peenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqy.teWpdhdvPekatslldll......krirksrekt.qsgPivvhCsaGvGR

CASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
  .|.|  .|  .. | |     .|  ..|  |     |.. .
tGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqY
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 25-279 1.1e-08 29.4 In-house 7-261 (287) alignment 
Range on Protein: 25-279
Range on HMM: 7-261/287.0
VDEFVHLQTTRGKETYQQDL---DDMNLDDEKIERFI--RNGEKNRFTNVTCFDE---ILDRENQEFF--VHANTFRTPYgNFLISQAPNDSTNADHLHL
..|||. .. .|.| ...     .... .....   |  .| .|||.|..   |.   .|  |....   |. ....  . .|.|...|  .|  .  .|
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekk.afiiaesPmfntarnfWkl

MWIYNVQTVVCLVLPEEAGG---YFVPKEGETfTSFQKYQIKTIGIFdEKQGVTVYQCELKSYKAPKKLNRRMVYIICCDTSVGSIRSPrqQTVIMeymw
..  ||...| |.  .|      |    |... ... .|.|. .     ..|... . |.|  .  .. .. . | |    | | . .|  ||...    
iddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtep..qtill....

AFEETnaIENEValADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTC
 .||   . ..     . |...||  ..  | | |. ||.  ..  . |    ..   ..| .. .. 
vieem..yktqr..krgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsv
0036282 (Phosphotyrosine protein) phosphatases II 93-280 1.1e-08 30.5 In-house 15-154 (174) alignment 
Range on Protein: 93-280
Range on HMM: 15-154/174.0
PYGNFLISQAPNDstnadHLHLMWIYNVQTVVCLVLPEEAGGYFVPKEGETftsfqkyqiktigifdekqgvtvyqcelkSYKAPKKLNRRMVYIICCDT
  ......|.| .     ...... ....|||.|  ..| | | ..    .                              .. ...|. . .|. . | 
itprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.............................lredlerlgiqylylpwpDh

SVGSIRSpR-QQTVIMEYMWafeetnaienevaLADATTTVLVHGIAGTRRCASFVVAAVMCKQLLeTGQFSAMETWFEMRKRRAHTCT
.| ..     .   ..|                . |   .||||  ||  | . .|.|  |...|| ..   |...  |.|. | . ..
gvpdlsi.llefvkfveeal.............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 61-277 2.2e-08 28.5 In-house 29-249 (274) alignment 
Range on Protein: 61-277
Range on HMM: 29-249/274.0
GEKNRFTNVTCFD-------EILDRENQEFFVHANTFRTPYG---NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGG----YFVPKEGET--F
 .|||....   .       .   ....  .. ||  . . .    ..  | |  .| ||  ....  .|| .| |   .||       . |.. ..   
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

TSFQKYQIKTIGIFdEKQGVTVYQCELKSYKAPKKlnrrmVYII-CcdTSVGSIRSPRQQTVIMEYMWAFEETNAIENEVaLADAtttvLVHGIAGTRRC
  ... .||. .|  |... .| .  ||. . ...     |. .    |.    .||.. . ... .   ||..  ||.  || .    .||  ||  | 
erygdveikvekiv.erndysvrklvlkylerers.....vkhywy..tdWPdhksPddantlldlvleveesreeenak.lapv....vvhCsaGiGrt

ASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAH
  |. . . ..|| |..    ...  ..|  |  
GcfiaisiavrqlreeivvdvlkivcnlrldrGG
subfamily_Ptp69D_pd Subfamily Ptp69D 60-284 3.4e-08 28.0 In-house 48-274 (307) alignment 
Range on Protein: 60-284
Range on HMM: 48-274/307.0
NGEKNRFTNVTCFDEI------LDRENQEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGYFVPKEG--ETFTSFQK
|  |||. ... ||.       .  ...  .. |.  ..     .|...|.| ..|  |   ...  .|...| |   .|     ..|    |. . ...
nalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygd

YQIKTIGiFDEKQGVTVYQCELKSYK--APKKLNRRMVYIICCDTSVgSIRSPRQQTVIMEYMWAFEETNAIEnevaladaTTTVLVHGIAGTRRCASFV
  .|..  .....  .  . ..   |  ...  ..| |      .       |.. . .....   .| .  .         . ..||  ||. | . ||
ilvklvs.eekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvrelykln........rsPivvhCsaGvgrsgifv

VAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHD
  ... .|| .  . . .||  ..|..|    .. . 
aldsllqqlkaedkvdifetvkdLrsqRnllvqsleq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 50-296 5.8e-08 26.8 In-house 36-287 (305) alignment 
Range on Protein: 50-296
Range on HMM: 36-287/305.0
DDEKIERFI--RNGEKNRFTNVTCFDEI---LDRENQEFFVHANTFRTPYG--NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGyfvPKEGE
| ||.. |   .. .|||. .| |.|.    |.      ..|||   ||     |. .||| . | ||  .. .  .|...  |    | |     |  |
dfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekga...kkcle

TFTSFQKYQIKtigiFDEKQ-GVTVyQCE-LKSYK--APKKLNRRMVYIICcDtsvGSIRSPRQQTVIMEYMWAFEETNAIENEV-----ALADATTTVL
 |.| .| ...    |.||.  ..| ..|  ...|  .. | . .   ..  .   |.  . |. |      |      | .. .         .   . 
yfaskdkdvle....feekgqkisv.kfessvtlkfrkdakakvtetvlvi.e...gpgekarkvthyhwidwpdrgvpaadlailellekarpskgpiv

VHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWF-EMRKRRAHTCTRKHDFFSSVYTFFAFC
||  ||  |  | |.   ...|||.  .    .  .  .|..|  .    ....     .. ..
vhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 58-292 6.1e-08 27.2 In-house 7-237 (250) alignment 
Range on Protein: 58-292
Range on HMM: 7-237/250.0
IRNGEKNRFTNVTCFDE---ILDREN---QEFFVHA---NTFRTPyGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGYfVPKEGETfTSFQ
 .| ||||....  .|.   .| .|.   .  .. |   ....     |...|.|  .|  |   ... ....|.| |   .| .   ...   .    .
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv.ekae

KYQIKTIGIF--DEKQGVTVYQCELKSYKAPKK-LNRRMVYIICCDTSVgsirsPRQQTVIMEYMwafEETNAIENEValaDaTTTVLVHGIAGTRRCAS
||   |. ..  .|.  .|. .  | ..|  .. . |.. ..   | .|     |.. | ..|..   .. .| ....   . .. |.|.  ||. |  .
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv.....PevatavLell...kkvqasqqqa...g.naPvivqCsaGvgrsGa

FVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFfSSVYTF
|..   . ..| .  .   ..    .|| | |. . .. . ..||. 
fiaidavlerlkkekvvdvfkvikvlrkdrphavesleqy.vfvyei
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 48-284 2.6e-07 24.9 In-house 8-252 (270) alignment 
Range on Protein: 48-284
Range on HMM: 8-252/270.0
NLDDEKIERFIRNGEKNRFTNVT-------CFdEILDRENQEFFVHANTFR---TPYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGG---
. .....  ..|. . ||....        .  | |. ...  .. ||  |       ... ...| ..|  ... ..|  .|...| .   || |    
etsesdlpeaargkklnRyadiLPsPatRvrl.eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

-YFVPKEGETFTSFQKYQIKTIGIFDEK-QGVTVYQCELKSYKAPKKLNrRMVYIICCDTSVGSIRSprQQTVIMEYMWAFEETNAIENEValADATtTV
  . |.| .. ..... .||.. . .|| .|  . . .|..    ..|     |    | .| .     ...   . .  ...  . |.|   ..|.  .
erYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv.HfwyntWpdhgvpreed..sslstdqllkmlravrrsekel..dkae.Pl

LVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHD
|||  ||  |   ...   ... | ||..   ..   |.|| |       . 
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeq
subfamily_PTPRD_pd Subfamily PTPRD 59-312 2.7e-07 24.6 In-house 47-296 (564) alignment 
Range on Protein: 59-312
Range on HMM: 47-296/564.0
RNGEKNRFTNVTCFDE---ILDREN---QEFFVHAN---TFRTPyGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGY----FVPKEgEtft
 | .|||. |.. .|.   .| . .   .  .. |.   ..|..  ... .|.|  .| .|   ..| .|..|.| |   || |      . |.. .   
aNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkr.kayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g...

sFQKYQIKTIGIFDEKQGVTVYQCELKSyKAPKKLNRRMVYIICCdTSVGSIRSPRQQTVIMEYMWAFEETNAienevalaDATTTVLVHGIAGTRRCAS
  ..|.  |. . .|..  ..  ...|  |  |. . |.|      ||  .   | . | ... .   ...|         . .  ..||  ||  |   
.tetygeltVtleeeeeladyeirtfkl.kkkkssesreVrqFhF.tsWPdhgvpesatslLdlirkvralne........pdagPivVhCSaGVGRTGt

FVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFfSSVYTFFAFCVQSSAVSETNENYAKT
|.|  .| ... | ..   ...  ..|| | .   ... . . ...  .  ...   . . ||. ..
fividamlerikeektvDiyqyvkalrkqRnamVqteeQY.iFiheailealacgntevesenlkqh
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 60-301 3.3e-07 24.7 In-house 46-284 (318) alignment 
Range on Protein: 60-301
Range on HMM: 46-284/318.0
NGEKNRFTNVTCFDEI------LDRENQEFFVHANTFR--TPYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGGYFVPKegeTFTSFQKYQ
|  |||..|.. .|.       |. |..  .. ||     .   ... .|||   |  |   ..|  | ...| |   ||.|   | .    . | .  .
nkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhr...yWPskgsrs

IKTIGI-FDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCdTSVGSIRSPRQQTVIMEYMWAFEETNAienevalADATTTVLVHGIAGTRRCASFVVAA
.... .  .|.  .. |     . .  .. . |.|    . ||     .| . . ... .   .....          .....||  ||  |   |..  
ygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhy.tsWpdegvpesgaslldlvrqvskaqq.......ksgagpivvhCsaGvGrtGvfiavd

VMCKQLLETGQFSAMETWFEMRKRRAHTCTRKhDFFSSVYTFFAFCVQSSA
.. ... . .    ..|  ..|..|      . | .  .|.     ..|  
illerikaealvDvfqtvkqlreqrnlmvqte.dqyefiydvllealasgd
subfamily_PTPRB_pd Subfamily PTPRB 36-285 3.9e-07 24.4 In-house 23-274 (293) alignment 
Range on Protein: 36-285
Range on HMM: 23-274/293.0
GKETYQQDLDDMN---LDD-EKIERFIRNGEKNRFTNVTCFDEI------LDRENQEFFVHANTFRTP--YGNFLISQAPNDSTNADHLHLMWIYNVQTV
 .  .... ....    |   |. .  .| .|||.||.  .|.       |. |... .. ||  .      .|. .| |  .|  |  ...|  .....
sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssii

VCLVLPEEAGG----YFVPKEGETFtSFQKYQIKTIGIfDEKQGVTVYQCELKSYKAPKKLnRRMVYIICCDTSVgsirsPRQQTVIMEYMWAFEETnaI
| |    | |      . |.. |.   . . ... .   .|..  .. . ...  |. .|. |.. ..   |  |     | . . ..... ...|.  |
vmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvae.eeledwvirelkiekekeerkv.rqyhftsWpdhgv.....Pektktlldfvrtvrea..i

ENevalADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
|.    . ... ..||  ||  |   |.    . ... |.     . .  |.|..|..    ....
ek....taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqY
0051082 (Phosphotyrosine protein) phosphatases II 90-278 5.8e-07 24.7 In-house 8-135 (151) alignment 
Range on Protein: 90-278
Range on HMM: 8-135/151.0
FRTPYGNFLISQAPndstNADHLHLMWIYNVQTVVCLVLPEEAGgyfvpK-------EGetftsfqkyqiktigifdekqgVTVYQCELKSYKAPKklnr
|.   |....|..|     ||.| |.. ....|.|.|  .|| |     .       .|                      ..|... . . ..|.    
fsyvtgglyrsggp....ladflellkelgiktivnlrseeerg.....ycpeylpelg......................ievlhipildwpdpg....

rmvyiiccdtsvgsirsprqqtvimeY----MWAFEETNAIENevalaDATTTVLVHGIAGTRRCASFVVAAVMCKQlletgqFSAMETWFEMRKRRAHT
                                .. |  .....     .    ||||  ||  | . .|..  |. .      .|. |.. |.|..| . 
..........................lplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgv
0048076 (Phosphotyrosine protein) phosphatases II 212-282 7.8e-07 24.4 In-house 60-129 (145) alignment 
Range on Protein: 212-282
Range on HMM: 60-129/145.0
AFEETNAIE-----------NevaladaTTTVLVHGIAGTRRCASFVVAAVMCKqlletGQFSAMETWFEMRKRRAHTCTRK
... .. ..           .          ||||  ||  | ...|.| .| .      ..|. |.. ..|..| . ... 
vpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnp
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 55-298 9.7e-07 22.7 In-house 42-280 (303) alignment 
Range on Protein: 55-298
Range on HMM: 42-280/303.0
ERFIRNGEKNRFTNVTCFDEILDRENQEFFVHANTFRTP-YGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPE---EAGGYFVPKEGETFTSFQKY
..|..| .||||..| |.|    .  .  ..||.        . ...| |   | ||   ..   .|. |. |.      . || .|  . . |  |.. 
nqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkfeer

QIKtIGIFDEKQgvTVYQCELKSYKAPKKLNRRMVYIICCDT-SVGSIRSPRQqTVIMEYMWAFEETNAienevALADATTTVLVhGIAGTRRCASFVVA
 |. .| | . .   .    ||     .   . ....   ..   .|| |      ..  .|  .           .|.| || .  ..|  |. .| . 
sir.vgefkrve..lgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgs.pkfvkqiwqlqsvlr.....kysdstptvym.slsgcgragtfalf

AVMCKQLL-ETGQFSAMETWFEMRKRRAHTCTRKHdFFSSVYTFFAFCVQ
      |  |   .  .     .|. | |..      || |||..|  | 
etahlslhseqasldlvkclenvrngrlhavqnls.qfsvvytllaehvl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 60-128 1.2e-06 22.4 In-house 37-114 (281) alignment 
Range on Protein: 60-128
Range on HMM: 37-114/281.0
NGEKNRFTNVTCFDE------I-LDRENQEFFVHANTFRTPYG--NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVL
| .|||..|. |.|       . .  .|   ..|||  |.|.    ....| |.  | ||  ...|  |  ..| |. 
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 60-291 2.1e-06 22.1 In-house 51-278 (297) alignment 
Range on Protein: 60-291
Range on HMM: 51-278/297.0
NGEKNRFTNVTCFDE---ILDRENQE---FFVHANTFRTPYGNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEAGG----YFVpkeGETFTSFQK
| ||.|..|.  .|    .|   |..    .| |   ..   ... .| |...| ||   ... ..|.|.| |   .|       |.     .. |.| .
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWs...dkgvttfGd

YQIKTIGIfDEKQGVTVYQCELKSYK-APKKLNRRMVYIiccDTSVGSIRSPRQQTVIMEYMWAFEETNAIENEvaladatTTVLVHGIAGTRRCASFVV
  ...  . .|..|    . |..  |   ... ..  ..   .  . ...   . . .....   ...   ..|       . .||| .||  | . .. 
vsvvllsv.sereGfikrelevtkgkakarrvvkqyqfv...eWPdkaverkdsassllklisevrkdfsqnae.......gPllvhclaGvGrtgvllt

AAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDFfSSVYT
   .  .  .. .   ...   .|. | .    | .. . || 
idsvvaeakrekevdifglvkklrqerpylvqtkeqy.kfvyv
0048179 (Phosphotyrosine protein) phosphatases II 226-281 5.8e-06 21.6 In-house 80-130 (144) alignment 
Range on Protein: 226-281
Range on HMM: 80-130/144.0
ADATTTVLVHGIAGTRRCASFVVAAVMCkqlleTGQFSAMETWFEMRKRRAHTCTR
 .    ||||  ||  | ...|.| .|      . ..|. |.. ..|.|| . .. 
leeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpn
subfamily_PTPRG_pd Subfamily PTPRG 95-285 7.1e-06 19.5 In-house 91-276 (563) alignment 
Range on Protein: 95-285
Range on HMM: 91-276/563.0
GNFLISQAPNDSTNADHLHLMWIYNVQTVVCLVL----PEEAGGYFVPKegETFTSFQKYQIKTIGiFDEKQGVTVYQCELKSYKAPKK---LNRRMVYI
 .|...| |  .|  |  ...|  ||...| .        .    . ||  ..   ... |.. |   . .   || .  .|  |  ||    . ..|. 
kafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlie.eevlalytvrtlviknlklkkkkqcdteklvrq

ICCdTSVGSIRSPRQQTVIMEYMWAFeetnaienEVALADATTTVLVHGIAGTRRCASFVVAAVMCKQLLETGQFSAMETWFEMRKRRAHTCTRKHDF
  . |.     .| ...  . ..           . |  ...  ..||  ||. |   ..|   . ||. .  .    ..   .| .| .  . . ..
yhy.tkWPdhgvPehslpvLifvkks........saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqY
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 61-279 8.3e-06 19.7 In-house 51-264 (301) alignment 
Range on Protein: 61-279
Range on HMM: 51-264/301.0
GEKNRFTNVTCFDE----ILdRENQEFFVHANTFRTPyG---NFLISQAPNDSTNADHLHLMWIYNVQTVVCLVLPEEA----GGYFVPKEGETFTSFQK
 .|.|. .| |  .    ..  . .   .|||   |. |    |...|.| ..|  |   ..  |.|...| |    |       ...| . .     ..
kdkhryptvPckPstavevi.vdGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

YQIKTIGiFDEKQGVTVYQCELKSYKAPKKLNRRMVYIICCdTSVGSIRSPRQQTVIMEYMwafeetNAienevaLADATTTVLVHGIAGTRRCASFVVA
..||.    .      ... .|.   . .|.. | |      ..      |.  . ... |      .       . ..   ..||  ||  |  .|. .
fkikikn.kelilnkkiskrtlevedstgkfatrtvthyqy.sewtdrgvPkshaelfdlm......el......vkksekPivvhcsaGiGrsvafigt

AVMCKQLLETGQFSAMETWFEMRKRRAHTC
 .. ....   .    |.  ..|..| .. 
eylareveadptieltealkhlrehrwngv