Gene F47B3.1 in Caenorhabditis elegans

Synonym: CELE_F47B3.1, F47B3.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf6
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP089_AA protein Get Run
CeleP089_AA_52-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 53-357 7.1e-195 640.9 In-house 1-306 (307) alignment 
Range on Protein: 53-357
Range on HMM: 1-306/307.0
IVVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWA
.|||||||||||.||||||||||||||.||||.|.|||||||||||||||.|||||||||||.|||||||||||||.|..|||||||||||||||.||||
svvkpwvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwa

MAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVANLGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAIN
||||||||.|||||..||..||||.||||||.||||||||||||||||||||||.||||..||||||||||.|.|||||||||||||||||||.||||||
maiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltain

LLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAEL-LVGDYGEKYKK
||.|.|...||..||||||.||.||||||..|||||.||.||..|..|..||||.|...||.|.||||||||||.||||.|||||.|| |. .| ||| |
lleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekyak

WADDYA
| ||| 
wlddyn
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 49-343 1.4e-106 350.6 In-house 5-303 (305) alignment 
Range on Protein: 49-343
Range on HMM: 5-303/305.0
QKAMIVVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANT------DKNRYQDVPCQDKGRIVVKFPGlASDYIHANYLGTATNP-KKFICAQG
 ..  .|. .|.|.||.||. | .||| |||.|   ||  || ||        |||||||||||.  . .. |   ||||||||.|    | |.||||||
pqthpiveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkldkps.psdyihanyvgcpmipekrficaqg

PLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGeapNTISVANL-GAKKMAPDeQCINVTTLKVDW-GQGSRTIQHLQWENWP
||..|   || | ||.||| ..|||. .|.||.|| ||||. ||.|| .    . | | |. |.| |  |   |..|.|.. . |. . ...|||| .||
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk...sgivvenvsgskpmerd.aeiqitllnltysgdqkmsvrhlqwtewp

DRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAE
|||||  .||...|||| || . ||.|||||||||||||||| |. .|.    .|  | ||.| || .| .||||. |||..|||.| ||||.||| || 
drgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekyaa

LLVG
||  
llta
0040438 (Phosphotyrosine protein) phosphatases II 57-335 6.7e-78 257.5 In-house 7-282 (317) alignment 
Range on Protein: 57-335
Range on HMM: 7-282/317.0
PWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGL--ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMA
..... | ....|| .||. | . ... ... .. .| ||||| |... |  |.... .|    ||||.|.|  .   ..|||..||||.|| ..|| | 
lalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmv

IQEKVECVIMLCNCIETGKIKCHQYWPLeqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAIN
 ...|....||... | |..||.|||||  |..|..|.    ..| .|. ..    .. |...||.|    .. |||..|... .||| |||..  . ..
weqgvtvivmLteleelgrekcaqYwpl..getltygd....ftvtllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

LLSATRGN----QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKE
.|.| | .    ..|.|||||||.|||||..|. .. . .  .. .. . | .||||..|| ..|.. || .|...|| |.. ... 
fleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 49-332 4.1e-76 250.6 In-house 5-290 (305) alignment 
Range on Protein: 49-332
Range on HMM: 5-290/305.0
QKAMIVvKpWVQRTLDMGVQALVDEFRVLAKWTP-EGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfPGLASDYIHANYLGTATNPKKFICAQGPLENTQ
||  |. | .|.|||. | . |  ||  . ..   | | .   . ...||||.|| | |. |. .. .    .||||||. | ||||.|||.| |||.| 
qkkqil.k.fvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkle.gpwpheyihanyvstptnpkrfictqaplektc

HSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVANLGAKKMAPD---EQCINVTTLKVD-WGQGSRTIQHLQWENWPDRGV
  || | .|.||| ..|||| .| |  ||..|.. .....| | |  . |||    ....      .  .. | | ..  |. .| ..|  | .||||||
adfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
| ..|. ..||  .|  . || |||||||||||..| . |. |...||.     . ... .|  |  ||| . |||..|.|.| ||...
paadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
0036941 (Phosphotyrosine protein) phosphatases II 80-332 1.6e-75 249.5 In-house 26-280 (297) alignment 
Range on Protein: 80-332
Range on HMM: 26-280/297.0
WTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVkfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQY
  .  ... .. .| .|||| |... |. |...  ..  ||||.|.|. .   ..|||..||||.|| ..|| |  ...|....||....| |..||.||
lllgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqy

WPLEQGQKLVFGEapntISVANLGAKKMapDEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAG
||||.|. |..|.    ..| .|. ...  ... . ..||.|    .. |||..|... .||| |||..  . .... . |       ...|.|||||||
wpleegesltygd....ftvtllsvevv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaG

IGRTGTIVAIAYVQDKMMA--GENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.||.||..|. .. . .     |... . |..|.||..||...|.. ||..|...|| ... .
vgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0050432 (Phosphotyrosine protein) phosphatases II 69-331 3.4e-75 248.5 In-house 43-301 (308) alignment 
Range on Protein: 69-331
Range on HMM: 43-301/308.0
ALVDEFRVLAKWT-PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVkfpGLASDYIHANYLGTA--TNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
 |  ||. | ... .. ... .. .| ||||| |... |. |...   .  ||||.|.|  .    .|.|||..||||.|| ..|| |  ...|....||
lleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmL

CNCIETGKIKCHQYWPLEQG-QKLVFGeapnTISVANLGAKKmapdEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN--
....| |..||.||||||.| . |..|     ..| .|  ..    .. . |.||.. .  .. |||..|... |||| |||.     ...| . |    
tklvengrekcaqYwplelgggsleyg....kftvtllseev....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslp

QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
..||.||||||.|||||..|. .. . . .. ... . |..| ||..|| ..|.. |||.|.|.|| |.. 
ggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
DSPc_SM00195 77-329 5.1e-75 247.6 In-house 9-262 (263) alignment 
Range on Protein: 77-329
Range on HMM: 9-262/263.0
LAKW-TPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGK
| .  .|. .|......|..||||..... |. |. .| .     ||||.|||. .|...||.|..||||..| ..|| | ..|||....||... | ||
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

IKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMApdeQCINVTTLKVDWGQ--GSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQN----PILVH
.||..||| |.|.| .||    .||| .   .|.    . |...||..   .   .|.....|..||||.|||...   ..||.| .  ..    ||.||
ekcdrywpeesggketfg....kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
||||.|||||.|.| .. .|. .... . . |..||||..|| ..|.. |||......| |.
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 77-329 5.1e-75 247.6 In-house 9-262 (263) alignment 
Range on Protein: 77-329
Range on HMM: 9-262/263.0
LAKW-TPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGK
| .  .|. .|......|..||||..... |. |. .| .     ||||.|||. .|...||.|..||||..| ..|| | ..|||....||... | ||
leestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengk

IKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMApdeQCINVTTLKVDWGQ--GSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQN----PILVH
.||..||| |.|.| .||    .||| .   .|.    . |...||..   .   .|.....|..||||.|||...   ..||.| .  ..    ||.||
ekcdrywpeesggketfg....kisvklvevekkk...deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
||||.|||||.|.| .. .|. .... . . |..||||..|| ..|.. |||......| |.
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045450 (Phosphotyrosine protein) phosphatases II 52-331 6.5e-75 248.0 In-house 11-306 (307) alignment 
Range on Protein: 52-331
Range on HMM: 11-306/307.0
MIVVKPWVQRTLDMGVQALVDEFRVLAKWTPE---GMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGL---ASDYIHANYL--------GTATNPKKFI
. .   .|...|  ... |  ||. | . |..    ... .. .| |||||.|... |  |.... ..     ||||.|.|         ..  ...|||
alkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfI

CAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD---WGQGSRTIQHLQ
..||||..| ..|| |  ...|....||....| |..||.||||.| |..|..|.    . | .|. ..    .. . |.||.|      . |||..|..
atqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn....ftvtllseeh....ldgytvrtlevtdldgtgesrtvthfh

WENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENC--MAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
. .||| |||..  ...... . |       ...|.|||||||.|||||..|. .. . . ... .  . . | .|.||..||...||. || .|...||
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

SYFLE
 ..|.
elllk
0039614 (Phosphotyrosine protein) phosphatases II 59-332 6e-74 244.5 In-house 23-292 (297) alignment 
Range on Protein: 59-332
Range on HMM: 23-292/297.0
VQRTLDMGVQALVDEFRVLAKWTPEgMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG---LASDYIHANYLGTATN-PKKFICAQGPLENTQHSFWAMA
....  .. . |  ||  | . .|. ... .. .| |||||.|... |  |...| ..   | ||||.|.|. .    ..|||..||||..| ..|| | 
lllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

IQEKVECVIMLCNCIETGKiKCHQYWPLEQGqklVFGEapntISVANLGAKKmapdEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLL
 ...|....||....| |. ||.|||| |.|   ..|.    ..| .|. ..    .. ..|.||.|  .. |||..|.|. .||| |||..  . ...|
weqgvtvivmLtklvelgr.kcaqywpeegg...tygd....ftvtllkveh....ldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefl

SATRG------NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
 . |       ...|.|||||||.|||||..|. .. . .  .  .. . | .||||..||...|.. || .|...|| ... .
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0046845 (Phosphotyrosine protein) phosphatases II 70-332 1.5e-73 243.0 In-house 2-277 (284) alignment 
Range on Protein: 70-332
Range on HMM: 2-277/284.0
LVDEFRVLAKWTPE---GMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA---SDYIHANYLGTA-----TNPKKFICAQGPLENTQHSFWAMAIQEK
| .||. | ..|.     ... .. .| .||||.|... |. |...| ..     ||||.|.|. .       ..||||..||||.|| ..|| |  ...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VECVIMLCNCIETGKIKCHQYWPLEqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVDW---GQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
|....||....| |..||.|||||| |..|..|.    ..| .|  ..    .... |.||.. .   .. |||..|... .|||.|||..    ...| 
vrvIVmltelvengrekcaqYwple.gevltygd....ftvtllseev....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflr

ATRGN------QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEN--CMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
. |        ..||.||||||.|||||..|. .. . . ...   .. . |..| ||..|| ..|.. ||......|| |.. .
lvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0051299 (Phosphotyrosine protein) phosphatases II 59-329 4.6e-73 241.5 In-house 14-286 (288) alignment 
Range on Protein: 59-329
Range on HMM: 14-286/288.0
VQRTLDMGVQALVDEFRVLAKWT-PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
|...|  |.  | .||. | ... .  ... .. .| .||||.|... |. |.... ..    ||||.|.|. .  ...|||..||||.|| ..|| |  
vlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvw

QEKVECVIMLCNCIETGKIKCHQYWPLeqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD------WGQGSRTIQHLQWENWPDRGVPQTNLT
...|....||....| |..||.|||||  |..|..|.    |.| .|  ..    .. . |.||.|       ... |||..|... |||| |||..   
eqnvrvIvmltklvelgrekcaqYwpl..ggsltygd....itvtllseev....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

AINLLSATRGN----QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 ...| . |      ..|..||||||.|||||..|. .. . . .. ... . |..| ||..|| ..|.. ||......|| |.
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 70-329 1.1e-71 236.8 In-house 14-272 (273) alignment 
Range on Protein: 70-329
Range on HMM: 14-272/273.0
LVDEFRVLAKWTPEGM-TTEAFSANTDKNRYQDVPCQDKGRIVVkfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNC
|  ||. | ...|..  .. .. .| |||||.|... |. |...  ..  ||||.|.|. .   ..|||..||||.|| ..|| |  ...|....||...
lleefelllslkplltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtel

IETGKIKCHQYWPLEQGQ-KLVFGEapntISVANLGAKKmapdEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------
.| |..||.||||||.|. .|..|.    ..| .|. ..    .... |.||.. .   . |||..|... .||| |||..    .... . |       
velgrekcaqYwpleggelsltygk....ftvtllseet....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
...|..||||||.|||||..|. .. | . .. ... . |..| |||.|| ..|.. ||..|...|| |.
sngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 62-329 7.9e-70 230.8 In-house 14-277 (278) alignment 
Range on Protein: 62-329
Range on HMM: 14-277/278.0
TLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA--SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKV
 |  . ..|  ||  | . ... ... .. .| ||||| |... |  |....  |    ||||.|.|. .   |.|||..||||..| . || |  ...|
lllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgv

ECVIMLCNCIETGKIKCHQYWPleqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT
....||... | |..||.||||   |. |..|.    ..| .|. ..    .. . |.||.|       |||..|... .||| ||| .  . ...| | 
ttivmLtelvelgrvkcaqYwp...ggsltygd....ftvtllkeeh....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

RG----NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
|     ...|.|||||||.|||||..|. .. . .. .  .. . | .||||..||...|.. || .|...|| |.
realedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 93-326 8.1e-70 230.2 Pfam-A 1-234 (235) alignment 
Range on Protein: 93-326
Range on HMM: 1-234/235.0
NTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGE
| .||||.|... || |. .|  . .||||.|||. . ...||||..||||..| ..||.| .||||....||... | |. ||.|||| |....| .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

APNTISvanlgaKKMAPDEQCINVTTLKVDWGQGS---RTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----NPILVHCSAGIGRTGTIVAIAYVQ
   ..       .|   ||. .....|...  ...   |....|...||||.|||...   ..|. . . ..    .|..||||||.|||||.||. .. 
ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
... | |... . ...||||..|| ..|.. || .|....|
eqlea.eeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 93-326 8.1e-70 230.2 In-house 1-234 (235) alignment 
Range on Protein: 93-326
Range on HMM: 1-234/235.0
NTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGE
| .||||.|... || |. .|  . .||||.|||. . ...||||..||||..| ..||.| .||||....||... | |. ||.|||| |....| .|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

APNTISvanlgaKKMAPDEQCINVTTLKVDWGQGS---RTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----NPILVHCSAGIGRTGTIVAIAYVQ
   ..       .|   ||. .....|...  ...   |....|...||||.|||...   ..|. . . ..    .|..||||||.|||||.||. .. 
ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
... | |... . ...||||..|| ..|.. || .|....|
eqlea.eeevdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 71-331 9.2e-69 227.2 In-house 11-274 (278) alignment 
Range on Protein: 71-331
Range on HMM: 11-274/278.0
VDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVvkfpglasDYIHANYLGTAtnPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIE
 . ...|.   |  .|.  .  | ||||| |... |  |..        |||.|.|. .   |||||..||||..| ..|| |  ........||....|
lefefllllgipseitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelve

TGKIKCHQYWPlEqGQKLVFGEapntISVANLGAKKMapDEQCINVTTLKVD----WGQGSRTIQHLQWENWPDRGVPQTN-----LTAINLLSATRG--
 |..||.|||| | |. |..|.    ..| .|  . .  |. .. . ..        .  ||...||.. .||| ||| ..     | ... . . .   
lgrekcaqywp.e.ggsltygd....ftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

------------NQNPILVHCSAGIGRTGTIVAIAYVQDKMmagENCMAMNELIKELRSHRPW-SIQNEFQYLYLHRVLLSYFLE
            ...|.|||||||.|||||.||. .. . .   |. . . | .|||||.||  ..||. || .|...|| ..| 
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 85-330 1.3e-66 220.1 In-house 3-247 (249) alignment 
Range on Protein: 85-330
Range on HMM: 3-247/249.0
MTTEAFSANTDKNRYQDVPCQDKGRIVVKF-PG-LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPL
...  . .| |||||.|... |  |....  ||   ||||.|.|. .   ...||..||||..| ..|| |  ........||... | |..||.|||||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

eqGQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAGIGR
  |. |..|.    ..| .|  ..    .. . |.||..     . |||..|.|. .||| |||..  ...... | |       ...|.|||||||.||
..ggsleygd....ftvtllsvev....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgR

TGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
|||..|. .. . .    ... . | .|.|||.||...||. || .|...|| ..|
tGtfiaaylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 87-329 2.2e-63 209.3 In-house 3-243 (245) alignment 
Range on Protein: 87-329
Range on HMM: 3-243/245.0
TEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA--SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLeq
. .. .| ||||| |... |  |.... .|    ||||.|.| ..   ..|||..||||..| . || |  ........||... | |..||.|||||  
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..

GQKLVFGEapntISVANLGAKKmapdEQCINVTTLKVD--WGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG-----NQNPILVHCSAGIGRTGT
|..|..|.    ..| .|. ..    .. . |.||.|       ||...|... .||| ||| .  . ...|.. |      ...|.|||||||.|||||
gesltygd....ftvtllseeh....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

IVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
..|. .. . . .   .. . | .|||||.||...|.. || .|...|| ..
fiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 91-332 8.1e-61 200.4 In-house 38-280 (290) alignment 
Range on Protein: 91-332
Range on HMM: 38-280/290.0
SANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKL
. |. ||||.|.   || |....       |||| ||..  .......| ||||| .| . || | .. .|| |.|.|. .| ||.||..||| |....|
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeel

VFGEapntISVANLGAKKMAPDeqcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN----QNPILVHCSAGIGRTGTIVAIAYV
 |||    ..| .   |..  |   . . ||||.  . ||... .....|||.|||..  . ..|... |      ..|..||||||.||||||.|| ||
efge....fevtleeekavddd...flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyv

QDKMMAGEN--CMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.. . |.    .. . .|. ||| .|.  .| . || .... ..... ..
rellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
0037934 (Phosphotyrosine protein) phosphatases II 89-328 8.6e-61 200.9 In-house 6-241 (243) alignment 
Range on Protein: 89-328
Range on HMM: 6-241/243.0
AFSANTDKNRYQDVPCQDKGRIVVkfPGlaSDYIHANYLGTAtnpKKFICAQGPLENTQHS----FWAMAIQEKVECVIMLCNCIETGKIKCHQYWPleq
 . .| .||||.|... | .|...  .|  ||||.||.       ...|. ||||..| ..    || |  ........||....| |..||.||||   
llpenlsknrysdilpydhsrvkl..eg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

GQKlVFGEapntISVANLGAKKMaPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR------------GNQNPILVHCSAGI
|.. ..|.    ..| .|. . . .|    ...   .|... .|...|... .||| |||..    ...|...|             ...|.|||||||.
gev.tygd....ftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGTIVAIAYVQDKMmagenCMAMNELIKELRSHRPW-SIQNEFQYLYLHRVLLSY
|||||..|. .. ...     .. . | .|.||..||  ..|.. || .|...|| .
gRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 62-328 1.2e-60 199.6 In-house 21-282 (290) alignment 
Range on Protein: 62-328
Range on HMM: 21-282/290.0
TLDMGVQALVDEFR-VLAKWTPE-GMTTEAFSANT--DKNRYQDVPCQDKGRIVVKfPGLASDYIHANYLGTaTNPkKFICAQGPLENTQHSFWAMAIQE
. ...|. |  |.   |  . |   .  . | .||   ||||.||.|.|| |...|  |   ||.||||.   ...  || .||.|..|   .| | .||
vvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk.dGydGdyvhanyvkG.lka.mfiltqGalkdtvidiwrmvlqe

KVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANlgakKMAPDEQCI--NVTTLKVDWGQgSRTIQHLQWENWPDRGVPQTNLTAINLLS
||  ..|||. || || ||.||.| ..|. | |||   |.  ..    .  .|.. |   ..  ..| |. .  ..||.   |||. |....|. . .| 
kvaaivmlceliedGkakceqyypekeGevltfGei..tvlcse....eddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlr

ATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
. |    |. ||||||||||||.|||    . .. | . . . .|.. ||  |  |.| . ||| | ..|| .
ilrkasGpvvvhcsaGiGrtGtfvaievglqilldGke.ldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPRD_pd Subfamily PTPRD 65-331 7.6e-60 198.1 In-house 20-283 (564) alignment 
Range on Protein: 65-331
Range on HMM: 20-283/564.0
MGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVV-KFPG-LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECV
 . . .  |.. . . . . ... . .||  ||||...   |. |.|  |..|   |||| |... . ...|..| .||||..| . || |  .......
nsdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnssti

IMLCNCIETGKIKCHQYWPLEqGqKLVFGEapntISVANLGAKKMApDEQcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR----
.|| .. | || |||.||| . | .  .||    . |     ...| | . |   .||    . ||.... .. .|||.|||..  . ..|..  |    
VmltkleEkgkvkchkYWPek.g.tetyge....ltVtleeeeela.dye.irtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne

GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
 .. ||.||||||.||||| ..| .. ... . |. . . . .|.||..|.  .|.| || ..|...| .   
pdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_PTPRB_pd Subfamily PTPRB 72-332 2.8e-59 195.6 In-house 29-288 (293) alignment 
Range on Protein: 72-332
Range on HMM: 29-288/293.0
DEFRVLAKWT-PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVK--FPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNC
.|.  | .    . ...   ..|..||||...   |. |. ..       |||| |||.   . |..|| .|||| .| . || |  ..|.. ..|| ..
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltql

IETGKIKCHQYWPLEQgQKLVFGEapntISVANLGAKKMapdeQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ------N
.| ||.||..||| .. .  ..|.    |.|  .  ...    .   . .||.  .. .|.......  ||| |||..  | .... . | ..      .
vekgkvkCeeYWPade.epvlyGd....ikvtlvaeeel....edwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskr

PILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
||.||||||.||||| .|.  . ...   |... .  .. |||..| . .|.| ||...|...|... ..
PivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 66-329 2.3e-58 192.5 In-house 13-276 (281) alignment 
Range on Protein: 66-329
Range on HMM: 13-276/281.0
GVQALVDEFRVLAKWTPEGMTTEAF-SANTDKNRYQDVPCQDKGRIVV--KFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECV
  . .. |.. ||.   .  .| ..  .|. ||||...   |..|..|  .     .||| ||.. . ...|..| .|||. .. ..|| | ...||. .
dnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsai

IMLCNCIETGKIKCHQYWPlEQGQklvfgeapnTISVANLGAKKMAPDEQCINV-TTLKV-DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT---
.|. . ||.||.|||.||| .. .         .......  |..|  |.   .  ..|.   .  .|....|.. .||| |||.|    ..  ..    
vmvtreieagklkChrYWP.ddns.........elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl

-RG-NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 .  .. |...|||||.||||| .|.  . ... | .. . ......||| .| . .|   || ......| ..
tekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 54-334 9.6e-58 190.5 In-house 5-276 (288) alignment 
Range on Protein: 54-334
Range on HMM: 5-276/288.0
VVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMtTEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAM
|.  |... |...|..|  |.|   . ... .  ..| ||. ..||...|. |  |. ..    .  ||.|| . .| .....|||| ||. |   .| |
vinawirlvlqiaveglkkeyrdspneasidi.idsfianptrdryenlprcditrvkls..ddpdfyiaanvvssakykrrlicaqaPlngtieelWkm

AIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApntisvANLGAKKMAPDEQCINVTTLKVDWG-QGSRTIQHLQWENWPDRGVPQTNLTAIN
 ... || ..|||. .| || |  .|.|...|.|  .|         .   || |  .. ..|..|..    . .  ...| . .|.| |||.  |. ..
llesdveyivmlcellekGkeksaeyfPsklGekarigrl......ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplr

LLSATRGNQNPILVHCSAGIGRTGTIVAIaYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYK
||   .  |.||.||.|||.|||||.. |  .  ...  .. .....|...|| .|  .|| | ||||.||..| ..| .  
llevlkslqkPivvhssaGvGrtgtlili.lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky
subfamily_PTPN9_pd Subfamily PTPN9 59-331 2.7e-56 185.8 In-house 7-292 (297) alignment 
Range on Protein: 59-331
Range on HMM: 7-292/297.0
VQRTLDMGVQALVDEFRVLAKWTPEGMTTE-AFSANTDKNRYQDVPCQDKGRIVVKF-PG-LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
|.   ..| . |. |.  . . ..||  .     ||  ||||.|| | |. |.|..  ..  |||||.||..    ..| || .||||..| . || |  
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvW

QEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEapntISVANLGAKKMApDEQCINVTTLKVdWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
...|  ..|   ..|.|..|| ||||||...   ||.    .||.|.  ...  | .   ..  .|   . ||.. | |   ||| |||..  . ...|.
eqevlvivmttrvvergrlkcgqyWpleeessaefgd....lsvsnveveeee.dykvrvleiknv.kteesrkvthfqflsWPdyGvPssaaslldvle

ATRGNQ-----------------NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
. | .|                  ||.|||||||||||| ... .  ...   .. . . | .| ||. | .||| . || . .  .| | ||
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 57-332 3.5e-54 178.8 In-house 10-282 (288) alignment 
Range on Protein: 57-332
Range on HMM: 10-282/288.0
PWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEA-FSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAM
 .|...  .. . ...|...||.   .  .| .  . | .||||...   |  |. .|    .  .||| |.|.    . ||.|..|||| .| . || .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

AIQEKVECVIMLCNCIETGKIKCHQYWPLEQgQKLVFGEapntISVANLGAKKMapdEQCINVtTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINL
  ..|.. ..|| . .| || ||..||| .. ..  .|.    . |  .. |..   |. ..  .| ..  .. ..|...|.  ||| |||. .   ..|
vyenktstivmltelveggktkCeeYWPdad.kpknyGs....vtvtlveskel...edfvlr.klllekkkteleitqyqylaWpdhgvPeskapllel

LSA----TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
|.        ...||.||||||.||||| .|.  . |.. . |. . . . ...|| .|.  .|.. || ....||||   |.
lrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 60-329 2.6e-53 176.2 In-house 15-283 (319) alignment 
Range on Protein: 60-329
Range on HMM: 15-283/319.0
QRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVV-KFPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQE
..  . | . |  ||. | . ... ...     | .|||||..   |. |.|. ...|   |||| |... .  . .||| .|.||||| . || |  .|
kalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWee

KVECVIMLCNCIETGKIKCHQYWPLEQgqKLVFGEAPNTISVANlGAKKMAPDEQCINVTTLKVDWgqgsRTIQHLQWENWPDRGVPQTNLTAINLLSAT
.. .|.||..  | .|.|...||| |.    ..|.   |.   .   ...   . ..|  . .|.     |...| |...||| .||.. .. ..||   
essivvmltklveklkvklkkywpeen..feeyGrlivtleeee.eledyiirklklnkkssevet....RevkhfqyteWpdhdvPekatslldllkri

-----RGNQNPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
     . .. || ||||||.||||| ...  . ...   |. . . . ...||  |.  .|.. || ... .|| . 
rksrektqsgPivvhCsaGvGRtGtfivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 47-329 2.6e-52 172.3 In-house 6-290 (310) alignment 
Range on Protein: 47-329
Range on HMM: 6-290/310.0
AHQKAMIVVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFP-GLASDYIHANYLGTATNPKKFICAQGPLEN
 |.| .  .. ..  |  .|.. || ..| |       .| ||.  .  |||| || |.|. |. .|       |||||||. |    . |||.||||. 
hhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqh

TQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQ-----G--QKLVFGEAPNTISVANLgAKKMAPDEQCINVTTLKVDwgqgSRTIQHLQWENW
|   || | .||. | ...||.  | |. ||  |||        |  .   ..|. . . . || |  . ||.  ..    ...       .. ..| ||
tiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnl.avtfvpdnvpvdeqpanlk....elrvslikwpnw

PDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
||||||. .  ..     ..  . | .||||||..|....||. .  ||.  |.. . ..|.. ||. .|   ||.|.|||...|| . . 
pdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglk.vdaeevktellksraiciqtelqyliidrvriifa
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 67-328 2.6e-52 172.9 In-house 21-282 (305) alignment 
Range on Protein: 67-328
Range on HMM: 21-282/305.0
VQALVDEFRVLAKWtPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG-LA-SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIM
 ..|  ... |..  .| .  .  .||. |||....  .|. || ..    |  |||| |.|. .  . ||.| |||||.|| . || . ..|||. ..|
dkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivm

LCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANlgaKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ---
|.. .| || ||.|||| ....|  |||   .. . .   .| |.|    ...  . |  . |||. ..|  .||| ||||.  . ..|.   . .|   
ltklveggkdkCrqYWpesktekkefgef..svelks...ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd

--NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
   |.|||||||.||||. .|.    ... . |. . . |..|.|||.|.  .|.  || .|| .|  .
kgvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 89-330 4.5e-52 171.7 In-house 16-265 (270) alignment 
Range on Protein: 89-330
Range on HMM: 16-265/270.0
AFSANTDKNRYQDVPCQDKGRIVVKFP--GLASDYIHANYL-GTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQG
..  ..  |||.|.  . . |....      |. || |||. |   ..||.|.|.|||..| .||| | ..|||....|. .  | |. || .||| |..
eaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

QKLVFgeAPNTISVANLGAKKMapdeQCINVTTLKVD-WGQGSRTIqHLQWENWPDRGVPQTNL------TAINLLSATR------GNQNPILVHCSAGI
.|. .  .  .|.|..|  .|.    .   .| |..  .|.  | . | ....|||.|||...         ...| | |       ...|.|||||||.
ekvkl..edgkikvlalseeke....egyiltrlrleekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGv

GRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
|||||..|. ..   .    . . ....|.||| .|.  .|   || .|..... |  
gRtGtlialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 62-329 5.7e-52 171.8 In-house 21-290 (298) alignment 
Range on Protein: 62-329
Range on HMM: 21-290/298.0
TLDMGVQALVDEFRVLAKWTP----EGMTTEAFSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
. ....  . .||. | . .     | ..    ..| .||||.|.   |. |.|..       |||| | .| .... . || .|.||..| . || | .
kkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

QEKVECVIMLCNCIETGKIKCHQYWPLEQGQKlvFGEapntISVaNLGAKKMAPDEQCINVTTLKvDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
.|......|| |  |..|.|.|.||| |. ..  .||    |.| .| .|.   |  . ...  |    ...|....|.. .|||.|||... . ..||.
eedigtiVmltnleeldktkyhkywPdegket..yge....itv.sllskeefadlivrklkvsk.kkeekerevrqlhftsWpdkgvpenatsvldllr

ATRGNQ-----NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
  | .|     .|..|.||||.||.|| .||  | ... . |. . . . .| || .|| ..| | || ... . | ..
kvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkk.eqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN3_pd Subfamily PTPN3 69-326 2.1e-51 169.5 In-house 16-272 (280) alignment 
Range on Protein: 69-326
Range on HMM: 16-272/280.0
ALVDEFRVLAKWTPEGMTTEA-FSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNP----KKFICAQGPLENTQHSFWAMAIQEKVECVI
|.. .|  | .  |.  ...|  ..| .||||.|.   |. |. .|     .||| |||.    .     ...| .||||..| . || |  ..|.. ..
avlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklk..esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssliv

MLCNCIETGKIKCHQYWPLeQGQKLVFGeaPNTISVANLgakkMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLL---SATR-G
|| . .| |..|||||||  ....| .|    .. . .      .  . ..   .||    . .|.| .||. .||| |||. .   ....    ..| |
mlttlverGrvkChqyWPe.tedeleyg..efsvkceke....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg

NQNPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
...|..||||||||||| ....      ..  .. . . ......|  |   .|.. || ..   .|
keePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_PTPN13_pd Subfamily PTPN13 68-327 4.9e-51 168.6 In-house 11-267 (273) alignment 
Range on Protein: 68-327
Range on HMM: 11-267/273.0
QALVDEFRVLAKWTPEGMTTEAFS-ANTDKNRYQDVPCQDKGRIVVKFPGLasdYIHANYLGTATN--PKKFICAQGPLENTQHSFWAMAIQEKVECVIM
|   .||. | .  |   .... . .|.|||||..|   |. |. ..  |    || |...    .    ..| .|||| .| . || |  . |.| ..|
qqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LCNCIETGKIKCHQYWPLEQGQKLVfgeAPNTISVANLGAKKMapDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN---Q
. .  |.||.|||.||| ....||.   . | . |..|. .|.  |.  ..  ..|    . || ..||.. .||| |||.. .  .....  |     .
vtlekekgkvkchrywPesknkklk...vsnrlevellkvqkl..dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

NPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
 ||.|||||||||.||...|  | . ... .. . ..|....||  |   .| . ||.. ....| 
gPivvhcsaGiGrsGtlitidvvlg.lierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 59-337 1.4e-50 167.2 In-house 11-288 (318) alignment 
Range on Protein: 59-337
Range on HMM: 11-288/318.0
VQRTLDMGVQALVDEFRVLAKWTPEGMT-TEAFSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAI
|.|    |   |  |.  |.. . .  .     ..|  ||||...   |. |. ..       |||| |||.   .. |..| ||.|| .| . || |  
vrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

QEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLvfgeapNTISVANLGAKKMapDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLS
. .   ..|| .. | ||.|.|.||| .. ...      ... |     ...  ..  .   ... .  . ||...  .. .|||.|||.   . ..|. 
eqnsavivmltqeeergkakvhryWPskgsrsy......gklvvelkeevel..sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvr

ATRGNQ-----NPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETY
 ..  |     .||.||||||.||||. .|.  . ... | |. . . . .|.||..|.  .| | || ... ||| .     .|. 
qvskaqqksgagpivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
subfamily_PTPN6_pd Subfamily PTPN6 90-331 2.5e-49 162.9 In-house 51-299 (306) alignment 
Range on Protein: 90-331
Range on HMM: 51-299/306.0
FSANTDKNRYQDVPCQDKGRIVVKFPGLAS-DYIHANYLG--TATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQ
   |. ||||. .   |. |...| |...  ||| |||.   . .. |..| .|| ||.|   || |. ||. . ..|. . .| || || .||| |. .
kpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeek

KLvFGEapntISVANLGAKKMApDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR--------GNQNPILVHCSAGIGRTGTI
.  .|.    ||| |.  |..| | .  ...  |.. .. .|.. ......||| |||.   . ...|.  .         .. ||.||||||||||||.
ee.yGk....isvtnvseksla.dYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtf

VAIAYVQDKMMA-GENC-MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
. |  . ....  | .. . ...|.| .|..|   .| | || ......  |  .
iviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 93-322 3.1e-49 162.4 In-house 50-273 (301) alignment 
Range on Protein: 93-322
Range on HMM: 50-273/301.0
NTDKNRYQDVPCQDKGRIVVKFPGLASdYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGE
. ||.||. |||. .  . |   |     ||||.. |  .|..||..||||.||.. |||| .| .|| ..||.. .|  . ||..| |.. ..||  | 
pkdkhryptvPckPstavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

APNTISVANLGAKKMApDEQCINVTTLKVDWgqGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgE
   .|   .|  .|    .. ..|.    ..   .||. | |...|.|||||..     .|.   .  ..||.|||||||||. . ..  |.  .. | .
fkikiknkelilnkki.skrtlevedstgkf..atrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarevea.d

NCMAMNELIKELRSHRPWSIQNEFQyLYLH
. . ..| .|.|| ||  ..|...| ||  
ptieltealkhlrehrwngvqtnsq.lywm
subfamily_Ptp69D_pd Subfamily Ptp69D 70-329 4e-49 162.4 In-house 24-286 (307) alignment 
Range on Protein: 70-329
Range on HMM: 24-286/307.0
LVDEFRVLA-KWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLC
|. |.. |  . ..   .. .   |. ||||.|.   || |...|  .|   |||| |... .  . ||||.||.|.|.| . || |  . .|. ..|| 
lakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

NCIETGKIKCHQYWPLEqgQKLVFGeapnTISVANLGAKKMA-PDEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT----RG
|  |. . ||..||| |  ..  .|     | |     .|.    .. ..|.. | .    . || .   .. .|.|  ||..  . ..|..      . 
nlteknrkkcakYWpie..devqyg....dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykl

NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
|. ||.|||||| ||.|..||.. . ... | |... . | .|.|||.|.  .|.  || .|.| || | 
nrsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 92-329 8.7e-48 157.7 In-house 8-242 (250) alignment 
Range on Protein: 92-329
Range on HMM: 8-242/250.0
ANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIkCHQYWPLEQGQKlv
.| .|||| |.   |. |.|..       |||| | .| . .. | || .||||..|   || | ..||.. ..|| |  |..|  .||||| |. .|  
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekaek..

FGEapntISVANLGAKKMApDEQcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN-Q----NPILVHCSAGIGRTGTIVAIAYV
.|.    . |  |  ...| | . . .  |     ...|....|.. .|||.|||..  ....||.  . . |    .|..|.||||.||.|. .||  |
yGd....vtvsllskeefa.dyt.krklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

QDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 ...   |. . . ..|| || .|| ... . || ......| . 
lerlkk.ekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPN23_pd Subfamily PTPN23 85-328 3.1e-47 155.8 In-house 35-279 (288) alignment 
Range on Protein: 85-328
Range on HMM: 35-279/288.0
MTTEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGT--ATNPkKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPL
... .   ...|||..|.   |. |....  |   ||| | ..    .. | .||..|.||..|   || |  ..|.. ..|| .  |.|| |...||| 
rsiaiaklyseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPe

EQGQKLVFGEapntISVANLGAKKMAP-DEQCINVTTLKVDwgqGSRTIQHLQWENWPDRGVPQTNLTAINLLSA--------TRGNQNPILVHCSAGIG
..|.  .||.    .||.    ... .  |. ....||..|     ....|||...||. |||..  | ...| .         |  . |..||||||.|
dkgetvkfgd....lsvtlksvretethvervlkletldad...avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
|||..  .  .  .. .|.  . . .... ||  | ...|.. |.  .  . | .
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRA_pd Subfamily PTPRA 88-332 5.4e-47 155.3 In-house 53-298 (330) alignment 
Range on Protein: 88-332
Range on HMM: 53-298/330.0
EAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPlEQG
 .   | .|||. ..   |  |...    |   |||| | ..    . .||| ||||.|.| . || |  . |   ..|| .  |  . ||.|||| ..|
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP.deG

QkLVFGEApnTISVANLG-AKKMAPDEQCINvTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN----QNPILVHCSAGIGRTGTIVA
  . .|.   ...| .   .....  . ...    .    . || .. . .. ||| ||| .    ..|| . .       .|| ||||||.||||| ..
l.vtyGni..rvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfiv

IAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.  | ... | |. . . | .|.||  ||  .| . || ....||| |.|  
ldavlervka.erkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_PTPRG_pd Subfamily PTPRG 72-338 9.2e-47 154.5 In-house 23-296 (563) alignment 
Range on Protein: 72-338
Range on HMM: 23-296/563.0
DEFR-VLAKWTPEGMTTEAF--SANTDKNRYQDVPCQDKGRIVV-KFPGLAS--DYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
 ||  .  . ... ...|.     |  |||| ..   |. |. . . ||  .  ||| |||.      |.|| .||||..| . || |  ...|. ..|.
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmi

CNCIETGKIKCHQYWPLEQGQKLvfgeapNTISVANLGAKKM-APDEQCINVTTLKVDWGQG---SRTIQHLQWENWPDRGVPQTNLTAINLLS----AT
 |  | |. ||..||| .. ...      ....|     ...  . .. . .  ||.. ..     ..... .. .||| |||. .|  ..       |.
tnlvergrrkcdvYWPkdesety......galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaan

RGNQNPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYA
. .  ||.||||||.||||| ...  .  ..   || . . ...| .|..|.  .|.| ||..|| .||.  . . .|  |
kaeaGPivvHcsaGvgrtGtyivldtllkqi.qqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketella
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 70-330 2.1e-46 153.1 In-house 22-284 (290) alignment 
Range on Protein: 70-330
Range on HMM: 22-284/290.0
LVDEFRVLAKWTPE-GMTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL---ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIM
  ..| .| .   |  .|..  | |  .||....  .|  ||...  .|    . .||.| |.    . |..| .|||..||   || .  |||| ...|
frnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivm

LCNCIETGKIKCHQYWPLEqGQKLvFGEApnTISVANLGAKKmAPDEQCINVTTLKVDwgQGSRTIQHLQWENWPDRG---VPQTNLTAINLLSAT--RG
|.| || || ||.|||| . ..|  .||   .| . |  . .    |. ..|.  . .  . .......|  ||.. |    ||| |..|.    |  . 
ltniieegkvkCqqYWpds.dtka.ygef..sikllneetln.eyierklevknknsa..gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkr

NQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
 ...|.||||...||... .|.|   .|.   |  . . ...|..|. .| |.| . || ......|.|. 
gntsivvHCSdtvgrsavfcaaattinkckt.egvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
0051429 (Phosphotyrosine protein) phosphatases II 119-332 2.1e-46 154.1 In-house 4-228 (272) alignment 
Range on Protein: 119-332
Range on HMM: 4-228/272.0
SDYIHANYLGTATN---PKKFICAQGPLENTQHSFWAMaIQEKVECVIMLCNCIETGKIKCHQYWpleqgqklvfgE-----------------APNTIS
|.||.|...|. ..   |.......|||..|...||..  .... ....|... | |. ||..||           .                   . ..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw...........pgirylhlpilddsaptilygalr

VANLGAKkMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNltAINLLSATRGnQNPILVHCSAGIGRTGTIVAIAYVQdKMMAGENCMA--
| .|  . . .|  . . .  ..   . .|.. ||.. .|||.||||     ..||.. .  ..|.|||||||..||||.||. ..    .  |  ..  
vtllsee.llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddY

------MNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
      . | ..|||..||...|.| |||.|...|| .. . 
lltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0041856 (Phosphotyrosine protein) phosphatases II 93-332 9.2e-46 151.1 In-house 1-174 (182) alignment 
Range on Protein: 93-332
Range on HMM: 1-174/182.0
NTDKNRYQDVPCQDKGRivvkfpglASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCncietgkikCHQYWPleqgqklvfge
| |||||.|... | .|         .|||.||..  .  ...||..|||| .|  .|. |  .... ....|.         ...|||           
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...........

apntisvanlgakkmapdeqcinvttlkvdwGQGSRTIQHLQWENWPDRGVPQtNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKmmage
                                   |.. .... .||| |||    ...... . . ...|.|||||||.|||||.||. ..  .     
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....

nCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
  . . | .|..||.|| ..... || .|...|| ..| .
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 54-349 3.4e-45 149.1 In-house 5-296 (312) alignment 
Range on Protein: 54-349
Range on HMM: 5-296/312.0
VVKPWVQRTLDMGVQALVDEFRVLAKWTPEGMTTeAFSANTDKNRYQDVPCQDKGRIVVkfPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAM
..| |    .    | |  |.. . .  ..   | ||    | ||| .. | |.||. .   |    |||||..   |.|..|.|.|||||||   || .
mikkwasavmmstpqqltkeykavgnivsdsect.aflkfkdlnrypniqcwdrgrftl..agdenfyihanfvkictkperfvctqgplentcthfwql

AIQEKVECVIMLCNCIETGKIKCHQYWPL-----EQGQKLVFGEAPNTISVANLGAKKMApdEQCINVTtLKvDWGQGSRtIQHLQWENWPDRGVPQTNL
|.     ..|.||  .| |  || .|        .  .. |. |    | .      |..   . ..|  .|   || |. ..| ||  ||| |.|..  
alslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkit..hrvlkvv.vk.atgqesk.lnhyqwaswpdhgmpdscd

TAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAELLVGDYGEK
||  |||| . ...|.. |||||.|||||.. |  .   .        . .    ||  |  |..   ||.|  |..| ..  .      |     . | 
talrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhpr.kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfket

Y
|
y
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 66-329 2.3e-44 146.5 In-house 18-278 (287) alignment 
Range on Protein: 66-329
Range on HMM: 18-278/287.0
GVQALVDEFRVLAK--WTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVI
| .   . | || .   ... .| .  | | ||||....  .|. |...|  |   ||| | .. .  . |.|| |..|. ||   || .  ...|. ..
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaiv

MLCNCIETGKIKCHQYWPLEQGqkLVFGEApnTISVANLGaKKMAPDEQCINVTTLKVDwgQGSRTIQHLQWENWPDRG---VPQTNLTAINLLSAT--R
|||.  |. . .|.|||| |.   .|.||   .|.. |   ..    |. ..|.  . .  .  ....  |  ||...|    ||| |  |.    |  .
mlcqekendeevcyqyWpeeks..vvlGey..niellnee.vnagyierklevknknka..gdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk

GNQNPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
  . .|.||||...||... .|.|   .|    |  . . ...|. |  .| |.|   || ..  ..| | 
rgntsivvhCsdtvGrsamfcaaattinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 72-332 3.1e-44 146.1 In-house 23-280 (315) alignment 
Range on Protein: 72-332
Range on HMM: 23-280/315.0
DEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVV--KFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCI
.||. |    .   ..   . |  ||||...   |. |...        |||| | |. .  . | .|..||||. .   || | .||||  ..|. .  
eefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkq

ETGKIKCHQYWPLEQGQKLVFGeapnTISVANLGAKkmaPDEQCINvTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN----QNPIL
|  |||| |||| ....   ||    .|.|. |  .   .| . ..   | .  .. |||.   |...|||.||..   . ..|. . ...    . ..|
egdkikcrqywPdrkadsvefG....sikvellsle...adtdgva.rklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsll

VHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
||||||.|||| ...|  | ...   .. . . ...|.||..||  .| | .| ... ..| ..| |
vhcsaGvGrtGvvisidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledllwr
0046846 (Phosphotyrosine protein) phosphatases II 110-328 6.1e-44 145.2 In-house 3-172 (176) alignment 
Range on Protein: 110-328
Range on HMM: 3-172/176.0
IVVKFPGLASDYIHANYLGTAtnpkKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLvfgeapntisvanlgakkmap
... ...| .|||.||.. ..    ..|. ||||..|  .|..|  ......|..|....|.|..||..|||.... ..                     
lrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

deqcinvttlkvdwgqgsrtiqHLQWENWPDRGVPQTN--LTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAyvqdkMMAGENCMAMNELIKELRSH
                      . .. .||| |||. .  |......   . . .|.|||||||||||||.||.      ..  |... ..| ....|..
......................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreq

RP-WSIQNEFQYLYLHRVLLSY
|| ...|.. || .|....| .
RplgavqtpeQyrflyefelll
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 79-331 7e-44 144.9 In-house 21-272 (285) alignment 
Range on Protein: 79-331
Range on HMM: 21-272/285.0
KWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFpgLASDYIHANYLGTAT-NPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCH
 . |   |  |. || | ||| || | .. |.|.|      |||||...     .   .| .|||| .|   || |  |||.  |.|||  .| |  || 
gymppnctytayeanpdlnryadvrcieetrvvlkn..hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

QYWPLEQGQKLVFGEAPNTISvaNLGAKKMApdEQCINVTTL--KVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT---RGNQNPILVHCSAGI
 |.| . |. . ||.   |..  .   . .|     .|  |.    |       ..|.|   |||.  |.     |.|         ...|| ||||||.
lyypeklgevvkfgkyeitlt..eckeeaia..gtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagv

GRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
||| |.| | |   ..|   | . | ....|.|. |  ..|. .|.|.|. ||. ||. 
grtatfvgidyatirimenpn.iemldivremramrfqavqshmqflflyvvlmeyfig
subfamily_PTPRK_pd Subfamily PTPRK 82-327 7.6e-44 144.8 In-house 32-275 (314) alignment 
Range on Protein: 82-327
Range on HMM: 32-275/314.0
PEGMTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQY
.||  .     | .|||..|.   |. |....   |   |||| |... . ..|..|| .||||..| . || .  .|.  ...|| . .|.|..|| .|
fegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

WPlEQGQKlvFGEapntISVANLGAKKMApdEQCINVTTLKV--DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT----RGNQNPILVHCSAGIG
|| |....  .|.    | |  . ..  |  |  . . ...      .. |.....|. .||| .||. . . ..|.         .. .|.|||||| |
WP.edtev..ygd....ikvelvetella..elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaG

RTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
|||| .||. | | |.  |. . . . .|.|||...  .. | || ... |.| 
rtGtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 88-329 1.4e-43 143.9 In-house 23-268 (274) alignment 
Range on Protein: 88-329
Range on HMM: 23-268/274.0
EAFSANTDKNRYQDVPCQDKGRIVVKFPGLA---SDYIHANYL-GTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLE
.  . .. ||||...   .. |....        |.|| |||. |  .. | .. .|||| || . || |  ||.|. ..|| .  |. . ||..|.| .
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

QGQKLvfGEAPNTISVANLGAKKMapDEqcINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG-------NQNPILVHCSAGIGRTG
.. ..   |  . ... . ....   ..   .|..| .   . .|...|  . .|||. .|.   | ..|.  ..        .  |..|||||||||||
edyei..serygdveikvekiver..nd..ysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

TIVAIAYVQdKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
  .||     . .  |. . . ... .|| .|   .|.. || ..||.|  | 
cfiaisiav.rqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 92-326 5.3e-43 141.9 In-house 2-236 (237) alignment 
Range on Protein: 92-326
Range on HMM: 2-236/237.0
ANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLG-TATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPlEQGQKLVF
 |  |||| .. . |. |.|.| .| .|||| |.||      |||.|.||||||.. . || |  |||   ..||   ||  ..|||.||| .  |   .
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaay

GEApnTISVAnlgAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAI----NLLSATRG--NQNPILVHCSAGIGRTGTIVAIAYV
|    |.|.     |.   |     ... |    .. | |.  |.  ||||||||   . .    |..  ..   .  | ..|||||.|||| .. |  .
gvl..tvslk...kkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidam

QDKmMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
  .    .. . . . .. .   ||. || . ||...|...|
lrq.akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 91-331 2e-42 140.2 In-house 47-281 (315) alignment 
Range on Protein: 91-331
Range on HMM: 47-281/315.0
SANTDKNRYQDVPCQDKGRIVV--KFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEqgqKL
. | .|||| ..   || |. .        |||. ||..   . ....|.||||. .. . || .  .|..  ..|| | .|  | |. .||| .   |.
ienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kv

VFGEapntISVAnlgaKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATR----GNQNPILVHCSAGIGRTGTIVAIAYV
..|.    |.|.    .|    .. . | || |  |.  |..  |..  ||| |||.  .. .||    .     .  .|.||||||.||||| ...  |
iyGk....itvt....rkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldav

QDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
 |.. | || . . ..|. .|. |   .|   || ... .||  |. 
ldqaea.enaidvynfitgvrqnrikmvqvaeqyqfiydalletfvc
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 91-332 2.3e-42 139.8 In-house 41-279 (515) alignment 
Range on Protein: 91-332
Range on HMM: 41-279/515.0
SANTDKNRYQDVPCQDKGRIVVK--FPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKL
  |  ||||...   |. |. ..       |||. | |. .  | | .|..|||.. .   || . .||.|  ..|. .  |  |||| .|||   |. .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

VFGEapntISVANLGAKKmapDEQCInVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ----NPILVHCSAGIGRTGTIVAIAYV
 ||.    |.|  .  .    . . |   .|.|  |. |||.   ....|||.|||.   . . |. . . ..     |...|||||.|||| ...|  |
kfGs....ikvelvslea...ctggi.krkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsv

QDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
  ..  ..  . . .... .| .||  .| . || ... ..| ..| |
vahakttrm.vdvfnfvtnirqkrpylvqtqeqyafiygavledllwr
subfamily_PTPN1_pd Subfamily PTPN1 88-317 3.1e-42 139.3 In-house 27-259 (290) alignment 
Range on Protein: 88-317
Range on HMM: 27-259/290.0
EAFSANTDKNRYQDVPCQDKGRIVVKFPglASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQG-Q
  . .| ..|||.||   |. ||...      ||| |. .      ...| .|||| ||   || |  ..|  .|.|| ...| ..|||.|||| ..  .
aklpenrnlnryrdvspydhsriklera..dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeek

KLVFGEAPNTISVANLGAKKMapdeQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRG------NQNPILVHCSAGIGRTGTIVA
.|.. ..  .. . .   |..      ...  |.    | .|.| |  .  ||| |||..  . ...|   |       .. | ..||||||||.||.. 
ellledtklkvkliseerksy....ytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl

IAYVQDKMMAGEN--CMAMNELIKELRSHRPWSIQNEFQ
.  .  .. . ..  .. ... . |||..|   ||   |
vdtclvliekkddlssvdikkvllelrkyrlGliqtadq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 65-337 2.9e-41 136.0 In-house 8-276 (281) alignment 
Range on Protein: 65-337
Range on HMM: 8-276/281.0
MGVQALVDEFRVLAKWTPEGMTTE-AFSANTDKNRYQDVPCQDKGRIVVKF--PGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVE
| .. . .||  |    |  . |      |  |||| ..|| |  |. .|.  |   ..|||||||. .    . .| .||| ..|.  || |  ||.  
mtlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentt

CVIMLCNCIETGKIKCHQYWPLEQGQKLVFgeapNTISVANlgakKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN
...|||. .|| . || .|.| .    | |    . .||.     . .  .. .  | |.. .   .| | |  |..|||  ||..    ...|   |  
aivmlcqfletnrekcaeyfprnahcclqf....dklsvsy....edstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar

QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRS-HRPWSIQNEFQYLYLHRVLLSYFLeRYKETY
  | ..|||||.||.||..|.    . . .      .....  ||   |  |.|   ||. . .||| . .  ||.  
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgv.aykqit
0036282 (Phosphotyrosine protein) phosphatases II 119-323 3.4e-41 136.2 In-house 2-164 (174) alignment 
Range on Protein: 119-323
Range on HMM: 2-164/174.0
SDYIHANYLGTATNPKKFICAQGPLEntqhsFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLeqgqklvfgeapntisvanlgakkmapdeqcinvtt
||||.|..|.    ....|. ||||.     ||.|  ......|.||....| |. ||..|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

lkvDWGQGSRTIQHLQWENWPDRGVPQTNLtAINLLSATRGN-----QNPILVHCSAGIGRTGTIVAIAYVQDKMMagENCMAMNELIKELRSHRPWSIQ
   ..   .|.. .... .|||.||| ..   ...... .       ..|.|||||||.|||||.||. ..   ..  |. .   .|..|||..||...|
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvq

NEFQYLYLHR
.. || .|. 
tpsQyrflyy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 68-330 3.9e-41 136.2 In-house 23-289 (325) alignment 
Range on Protein: 68-330
Range on HMM: 23-289/325.0
QALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKvECVIML
...  || .|    .  ... .  .| .|||...|   || |.|..  .    |||| |.|| .  . . |. || || .| . .| .... .   |...
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvv

CNCIETGKIKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMapDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA---------
 | ...|| .| .||| | |.   ||    .. |    ....   .    |  .|   .  .|... .|.  |.| ||..   | |..|           
lneldlgkdrcavywpkemgksktfG....glevklrtieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservt

-TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
       |||||||||.||||. ...  . .|..  |  . . . .| || .||  ..   ||  ..  |  ...
antkastpilvhcsaGvGrtGvfislysalakvie.esrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 64-331 8.2e-41 135.3 In-house 30-293 (319) alignment 
Range on Protein: 64-331
Range on HMM: 30-293/319.0
DMGVQALVDEFRVLAKWTPEGM--TTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKV
|  .. |  ||| ..| ....   |      | ||||. ..   || .. ..   |   |||| | ..    ...|.| |||||.||   || |  . ..
dddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweync

ECVIMLCncietgKIKCHQYWPLEQGQKlvfgEAPNTISVANLGAKKMapdeQCINVTTLKV-DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA--
  ...|       | || |||||.  .|    |    ..|  .   .       .    |      .. | |.   .  ||| |||.     . |.    
stivllt......kdkcsqywplkivik....eerfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvr

----TRGNQNPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
       ....|.||||||.||||. ...  . | .|  |. . . .....||  |.  .|.  || ...  ||  .| 
hltskenhranivvhcsaGvGrtGvyivldvlld.rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_egg_pd Subfamily egg 70-356 1.1e-40 134.3 In-house 16-291 (307) alignment 
Range on Protein: 70-356
Range on HMM: 16-291/307.0
LVDEFRVLAKWTPEGMTTEAFSAN-TDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLC
|   . || . . |   |.|.|.|  .| | . |.|.|  |. ....    . |.||||..       .||.|| || ||.. || |  ||.|. ..|| 
lerrlevleesvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlt

NCIETgkIKCHQYWPLEQGQKLVFgeAPNTISVANLGAKKmAPDeQCINVTTLKVdWG--QGSRTIQHLQWEnWPDRGvpqTNLTAINLLSATRGNQNPI
   |.   .|. |||  . . ||.   | .. . ||. .. ..|    .|| ||.  |  .  | ..| |.. .   .      . ...|   |   .|.
srkes..erceyywpkaesdslvt..vpGslrienlkvds.kad.plfrvtklkl.vGgddeerflehwqgd.vnnss...dvysplrvlrklrnlskpv

LVHCSAGIGRTGTIVAIAYVQDKMMAGENC-MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYkETYAELLVgDygekYKKWADDY
.|..  |. ...|.|||     ... |      . . .. || .|. |..  ..||...|..| .| .    .  || | |    |..| ...
vvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvi.gsakeldv.d....yerwleer
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 73-333 1e-39 131.8 In-house 3-259 (284) alignment 
Range on Protein: 73-333
Range on HMM: 3-259/284.0
EFRVLAKWTPEGM--TTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGL-ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCnc
||| ..| ...|   |      | ||||. ..   || .. ..   |   |||| | ..    ...|.| .||||.||   || |  . ..  ...|   
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

ietgKIKCHQYWPLEQGQKlvfgEAPNTISVANLGAKKMapdeQCINVTTLKV-DWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA------TRGNQ
    | || |||||.  .|    |    ..|  .   .       .    |      .. |.|.   .  ||| |||. .   . |.           ..
....kdkcsqywplkivik....eerfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhr

NPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERY
..|.||||||.||||. ...  . | .|  |. . . .....||  |.  .|.  || ...  ||  .|  .
anivvhcsagvgrtgvyivldvlld.rmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh
0043147 (Phosphotyrosine protein) phosphatases II 119-322 1.5e-39 130.8 In-house 5-154 (172) alignment 
Range on Protein: 119-322
Range on HMM: 5-154/172.0
SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCietgkikchqywpleqgqklvfgeapntisvanlgakkmapdeqcinvtt
||||.|.|| .   |..||. |||| || ..||.|  .... ....|...                                                  
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

lKVDWGQGSRTIQHLQWENWPDRGVPqTNLTAINLLSATRG-----NQNPILVHCSAGIGRTGTIVAIAYVQdkmmageNCMAMNELIKELRSHRPWSIQ
  .|. . .|.. .... .||| ||| .    ...|.  .      ...|.|||||||.|||||.||. ...        .. . | ....|..||...|
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavq

NEFQYLYLH
|. || .|.
npsqyrfly
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 91-329 1.6e-39 130.4 In-house 36-277 (287) alignment 
Range on Protein: 91-329
Range on HMM: 36-277/287.0
SANTDKNRYQDVPCQDKGR-IVVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEqGQKLV
 |.. |||| ||   |. | .... . | |||| |||. . |. ..||.||||.  |  .|| . .....  ||..   .| .. ||..|||    . . 
laavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmr

FGeapnTISVANLGAKKMAPDeQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINL-------LSATRG--NQNPILVHCSAGIGRTGTIVA
 |      ||  |  ... |.  ..    |    .. .| .. |.. .|||.... | .  | .       . ..|   .  |..||...||||.|...|
vG....GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGilla

IAY-VQDKMMAGEncMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
.   |.     |.  . .   .  || .|   .|   |. .|   | .|.
tlvlvsrledlGr..vdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 87-327 8.5e-39 128.1 In-house 27-264 (283) alignment 
Range on Protein: 87-327
Range on HMM: 27-264/283.0
TEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLG---TATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLE
 .. . |  |||.|..  .|. |. .|   .. ||| | ..       . ||.| ||.||..|.  || |  .||. ...|| .  |  .||| |||| .
iasadenkrknrnqeivpadqwrvelk..sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

QGQKlvFGEapNTISVAnlgaKKMAPDEQCINVTTLKVD-WGQGSRTIQHLQWENWPDRGvPQTNLTAI---NLLSA--TRGNQNPILVHCSAGIGRTGT
  ..  .||   |...     | .. .   |   .|.|.   . .  . | | ..| . | .|. . ..   |.. .  |. .. ||.||||.|||||..
Gsed..yGe..ftvtlr....kettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtav

IVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
 .|..   ...   |  . . . .| .| .|.  .|.  ||  .| . | 
fiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvle
0049772 (Phosphotyrosine protein) phosphatases II 86-330 2.1e-37 124.9 In-house 39-281 (314) alignment 
Range on Protein: 86-330
Range on HMM: 39-281/314.0
TTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTAtnpKKFICAQGPLENTQHSF----------WAMAI--QEKVECVIM---------
..  . .| |||||.|... |  .|. ..|.  ||||.|.|. .    .|||..|||||.| ..|          | | .  . .|  . |         
lvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlade

------------LCNCIETGkikchqywpleqgqkL----------VfgeapntisvanlgakkmapdeqciNVTTLKVDWgqgSRT-IQHLQWeNWPDR
            |... . |                                                    .... . ..   .|. |..|.. ..|| 
lsrLdaAlgKtpllildgng...............neptaadlellk.........................eelydpelf...erlgikylri.pvpDg

GVPQTNL--TAINLLSATrGNQNPILVHCSAGIGRTGTIVAIAYVQDKMmagenCMAMNELIKELRSHRP-----WSIQNEFQYLYLHRVLLSYFL
..| ..    ..... .   ...|.||||.||.||||| |..||.  ..      . ..| ....|. ||      .|..  ||.. ...|| |. 
saplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
0049260 (Phosphotyrosine protein) phosphatases II 131-322 2.4e-37 123.3 In-house 6-143 (152) alignment 
Range on Protein: 131-322
Range on HMM: 6-143/152.0
TNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWpleqgqklvfgeapntisvanlgakkmapdeqcinvttlkvdwgqgsrti
 .|..||..|||..||  .|| |  . .. ...||... | ||.||.||.                                                  
ampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..................................................

qHLQWENWPDRGVPQTNLTAINLLSAT----RGNQNPILVHCSAGIGRTGTIVAIAYVQdkmmageNCMAMNELIKELRSHRPWSIQNEFQYLYLH
 . .. .||| |||.     . || .     . ...|.|||||||.|||||.||. ..        . . . | .. .|..|| ...|. |. .|.
.qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPN14_pd Subfamily PTPN14 72-329 3.6e-37 123.0 In-house 27-296 (300) alignment 
Range on Protein: 72-329
Range on HMM: 27-296/300.0
DEFRVLAKWTPEG-MTTEAFSANTDKNRYQDVPCQDKGRIVVK-FPGLASDYIHANYLGT--ATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCN
 |.  ..|   .. ..| .   |..|||..||   .. |. ..      ..|| |  . .  ... ...| ||||||.| . || |  ...|. ..|| .
teyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte

CIETGKIKCHQYWPLE--QGQKLVFGEApnTISvanlgaKKMAPDEQCINVTTLKVDW--GQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA------T
 .| || |...|.| .  . ... ||.    ..      .|.  | ...  |.||. .   .  ||. |||. .|||.|||.   . .. |         
eeedgkeksfkyfPkleskkktvefgkf..kvt......tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

R-------GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
         .. |.|||||||.|||| ..    .   .  .|. . ... .. ||  |   .|.  || ....||. |.
tnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehnee.idikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 68-331 5.8e-36 119.1 In-house 26-286 (297) alignment 
Range on Protein: 68-331
Range on HMM: 26-286/297.0
QALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLA--SDYIHANYLGTATNpkKFICAQGPLENTQHSFWAMAIQEKVECVIML
.   .||. | . .    |.     | .|.||...   |. |. ..  .    |||. | .. .  .  ..|. | | ..|   |||| ..|.|  ..||
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

CNCIETGKiKCHQYWPlEQGQKLvFGEapntISVANLGAKKMA-PDEQCINVTTLKvdwGQGSRTIQHLQWENWPDRGVPQ--TNLTAINLLSATR----
 .  |. | || .||. ..| .  ||.    .||  |  ..     .. ..||  |    .  | ..  |. .|||. |..  .  . ..|.|  |    
nddnerdk.kcaryWs.dkgvtt.fGd....vsvvllsvsereGfikrelevtkgk...akarrvvkqyqfveWPdkaverkdsassllklisevrkdfs

GN-QNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
.| ..|.||||.||.|||| ...|  |  ..   |. . . .|.| || .||  .| . || ... ..| ..| 
qnaegPllvhclaGvGrtgvlltidsvvaeakr.ekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 70-329 1.3e-35 117.6 In-house 17-293 (301) alignment 
Range on Protein: 70-329
Range on HMM: 17-293/301.0
LVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKFPG----LASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
. .... | . ... .| .  ..|.  ||....   |. ||..|          .|| |.|.   .. |||| ||||...|   || . .|||.  ..|.
feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmv

CNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVAN---------LGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGV---PQTNLTAIN-
.|  |. | ||.||||  . ..  ||.  .|..  .         |  |     ..     ..||.  . |...  ||  .||. ||   |.| | .|. 
tnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvidd

-LLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 .    . .  |..||||....|.|. ...    .   | |    . ...| .|  .|  ..   ||  .. |.  |.
vihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQcka.egVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 72-327 4e-35 116.1 In-house 24-277 (439) alignment 
Range on Protein: 72-327
Range on HMM: 24-277/439.0
DEFRVLAKWTPE---GMTTEAFSANTDKNRYQDVPCQDKGRIVV-KFPGLA-SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLC
..|  .    |.     .  | . .  ||||.||   | .|... . ||.  | || |||.    ..| .| .||| ..| ..|| . |..|.  ..||.
eifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt

NCIETGKikchqYWPLEQgqKLVFGEAPNTISvANLGAKKMApdEQCINVTTlKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSAT-----RGNQ
| .|. |     ||| ..  . ..|.    .   |.   . .   . ..|   . | ..  ||. ....  |||. ||      ...| |      . . 
nlvesyk.....ywpsda..evcygdiavrvd.rnielpnyv..irgfkvfn.erdttekertvlqfhyiawpdknvpaqashvldflrainsandkeey

NPILVHCSAGIGRTGTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
 |..||||||.||||||.|.    ...   || . .. ..| || .|   .|.  ||....  .| 
gpvvvhcsagvGrtGtiialdialeql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_CG7180_pd Subfamily CG7180 90-331 2.1e-34 113.5 In-house 39-292 (296) alignment 
Range on Protein: 90-331
Range on HMM: 39-292/296.0
FSANTDKNRYQDVPCQDKGRIVV-KFPGLA-SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKiKCHQYWPLEQG--
 . | .|||. .|   |. |.|. |. | . |||| | |  . . .|..|  ..| ..| ..|| .  .|....|..|..  .  | ....||| ..   
rkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnkskeq

QKLVFGEAPNTISVANLGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPD-RGVPQTNLTAINLL---SATRGN------QNPILVHCSAGIGRT
 . .| |  .. . |||  ...    . . .|  . .     |.....|.  |.    ||    . |.|.      |..      ..|..|..| | .|.
ygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

GTIVAIAYVQDKMmAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLE
|  .||    ...   |... . | .| || .||  ..|  .| |.  ||| ..| 
Gvylaidanlelv.ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 101-342 5.7e-33 109.3 In-house 26-272 (290) alignment 
Range on Protein: 101-342
Range on HMM: 26-272/290.0
DVPCQDKGRIVVKFPG--LASDYIHANYLgTATNPKKFICAQGPLENT-------QHSFWAMAIQEKVECVIMLCNCIET----GKIKCHQYWPLEQGQK
.||   . |.| |  |  ...||||||.. |  |  ..|  | |.|..         .|| || ||||. |.|||.  |     ..  | .| | . |..
evpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee

LVFGEApnTISVanlgaKKMAPDEQcINVTTLKVDWGQGS-RTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQD
| |.    |..      |..  ... ... .| | ....   |..| . ..| .. |.....|...|..  . .. |..|||  || |  .. ||     
lkfkgl..tvkC.....kskekedd.vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQ

KMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKETYAELLV
|..  .. . .....|.||..|   |... .. .   ... .. | ..... |   
kiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeete
subfamily_ptpA1_pd Subfamily ptpA1 69-285 1.2e-32 108.1 In-house 22-253 (418) alignment 
Range on Protein: 69-285
Range on HMM: 22-253/418.0
ALVDEFRVLAKWTPEGMTTEA-FSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTAtNPKKFICAQGPLENTQHSFWAMAIQEKVECVIML
 . .|||.| .      |.|     || |||| ..   .. |. .|       |||| |||.  |  ||.|||.|||| ||   || |  ....  ..||
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivml

CNCIETGKIKCHQYWPLEQG--QKLVFGEAPNTISVANLGAKKMAP-DEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQ-
    |  .||| .||| . |  |  ..|.  . .   ..   ..    |. |    ... .   .| | . |.| |||. .|.      .|| .    | 
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

---------NPILVHCSAGIGRTGTIVAIAYVQ
          ||.||||||.|||||...   . 
qiipssdrnvpiivhcsagvgrtgtfctavimm
0044763 (Phosphotyrosine protein) phosphatases II 118-329 3.1e-32 107.0 In-house 17-171 (178) alignment 
Range on Protein: 118-329
Range on HMM: 17-171/178.0
ASDYIHANYLGtatnPKKFICAQGPlentqHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGqklvfgeapntisvanlgakkmapdeqcinvt
.||||.|..      |  ......|      .....  .... ....|.. .| |..||..||| | |                                
rsdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................................

tlkvdwgqgsrtIQHLQWeNWPDRGVPQ---TNLTAINLLSATR-GNQNPILVHCSAGIGRTGTIVAIAYVQDKmmagenCMAMNELIKELRSHRPwSIQ
            ||.|.. ..|| |||.     | ..... . .  ...|.|||||||.||.||.||. ..          . ..| |...|..||  ..
............iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRp.ivp

NEFQYLYLHRVLLSYF
|. |. .|... | ..
npgqlrqLyefelrll
0051082 (Phosphotyrosine protein) phosphatases II 119-325 3.1e-32 106.6 In-house 3-149 (151) alignment 
Range on Protein: 119-325
Range on HMM: 3-149/151.0
SDYIHANYLGTAtnpkkFICAQGPLEntqhSFWAMAIQEKVECVIMLCNCIETGkiKCHQYWPLEQgqklvfgeapntisvanlgakkmapdeqcinvtt
||||...|..       ... .|||.     |...  .... ....|..  |.|  .|..|.| ..                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

lkvdwgqgsRTIQHLQWENWPDRGVPQTNLTAINLLSATRGN-QNPILVHCSAGIGRTGTIVAIAYVQdKMmagencMAMNELIKELRSHRPWSIQNEFQ
         ... |.....||| |.|..  .....|.. . . ..|.|||||||.|||||.||.  .   .      . ..| ..|.|..|| ..| . |
.........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg......vsleealeeyrlkrpgvvqpnqq

YLYLHRVL
.|.....|
flfqlfal
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 93-326 1e-30 101.7 In-house 7-237 (239) alignment 
Range on Protein: 93-326
Range on HMM: 7-237/239.0
NTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGT-ATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGqKlv
|  |||| ..   |. |.|..       |||| |.||     .|| .|..|| .| .   || |  ||.   ..||   ||  | |||||||     |  
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k..

FGEAPNTISVANLGAkkmapdeQCINVTTLKVDWGQG-SRTIQHLQWENWPDRGVPQTNLTAINLLSA----TRGNQNPILVHCSAGIGRTGTIVAIAYV
. .   |.  ... |       . |  | .  . ||   | . . ..  |||.||||   . . |       .     | ..|||||.||||... |  .
ycnlrvtlrktevfa.......dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

QDKMMaGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
  .    .. . . . .| .|  ||  .|   ||...|  .|
lrqak.kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 92-326 1.1e-30 101.6 In-house 7-238 (239) alignment 
Range on Protein: 92-326
Range on HMM: 7-238/239.0
ANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGT-ATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGqKl
 |  |||| ..   |. |.|..       |||| |.||     .|| .|..|| .| .   || |  ||.   ..||   ||  | |||||||     | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k.

vFGEAPNTISVANLGAkkmapdeQCINVTTLKVDWGQG-SRTIQHLQWENWPDRGVPQTNLTAINLLSA----TRGNQNPILVHCSAGIGRTGTIVAIAY
 . .   |.  ... |       . |  | .  . ||   | . . ..  |||.||||   . . |       .     | ..|||||.||||... |  
.ycnlrvtlrktevfa.......dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

VQDKMMaGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
.  .    .. . . . .| .|  ||  .|   ||...|  .|
mlrqak.kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 72-332 2.3e-30 100.3 In-house 24-239 (392) alignment 
Range on Protein: 72-332
Range on HMM: 24-239/392.0
DEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKF--PGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCI
.||. |        |.     |  ||||...   |. |....       |||. | |. .  | | .|..|||   . . || |  ||.|  ..|. .  
eefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

ETGkikchqywpleqgqklvfgeapntisvanlgakkmapdeqcinvttlkvdWGQGSRTIQHLQWENWPDRGVPQTN---LTAINLLSATRGNQN-PIL
|                                                     |.  ||.   .. .|||..||.     |  |. ..|  |.   |..
egd..................................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpli

VHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLER
.|||||.|||| ...|  |  .       . . ... ..| .||. .| . || ...  .|  .| |
ihcsagvgrtgvvisidsvvahakktr.mvdvfnfvtnirrkrpymvqtkeqyafiygavledllwr
PTPc_DSPc_SM00012 229-326 4.7e-29 96.0 In-house 1-104 (105) alignment 
Range on Protein: 229-326
Range on HMM: 1-104/105.0
TIQHLQWENWPDRGVPQTNLTAINLLSATRGNQN------PILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLH
|..|... .||| |||..    ..|| |.. |.|      |..||||||.|||||.||.... .......... . ...||||..||...|.| |||.|.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

RVLL
|.||
rall
subfamily_PTPRN_pd Subfamily PTPRN 71-320 1.2e-28 94.8 In-house 32-283 (297) alignment 
Range on Protein: 71-320
Range on HMM: 32-283/297.0
VDEFRVLAKWTPEGMTTEA--FSANTDKNRYQDVPCQDKGRIVVKFPG--LASDYIHANYLgTATNPK--KFICAQGPLENTQHSFWAMAIQEKVECVIM
  |.  |...  |  |.|.     | .|||...|   |. |. .|       |||| |  . . ..|.   .| .|||| .|  .|| |  .. |  ...
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.ldhdprapayiatqgplastvadfwqmvweqGvvvivn

LCNCIETGKIKCHQYWPlEQGQKLVfgeapnTISVANLGAKKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQTNLTAINLL----SATRGN
|..  |.|  .|..||| ..|...        |   .| ....  |.  .    ||    . .||.  . .  ||..||| .  . ...      . || 
ltrleeegvkqckrywp.deGsevy......hiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

QNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLY
  ||.||||.| ||||. ..|  | .... | . . .   .. ||  ||  .. . |. .
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 139-328 1.8e-28 93.8 In-house 96-287 (302) alignment 
Range on Protein: 139-328
Range on HMM: 96-287/302.0
AQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEA-PNTISVANLGaKKmAPDEQCI-----NVTTLKVDWgQGSRTIQH
   |  .|.  .||.  | .|  |. ||. .| .. || .|.  . |..| ||.   .|.|| .   ..   | . .     ...  |.   .  .|.. 
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdl.ee.ftdkksfklytveiknekkkk.kvkktvdi

LQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDkMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
|..  ||| | |.   ||...|      .. .|||||||.|||||.||| |  . . . ..   . .... .|. |  ..|.| | .||  ..   
lafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiq.lcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkg
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 86-245 4.1e-28 93.1 In-house 26-181 (297) alignment 
Range on Protein: 86-245
Range on HMM: 26-181/297.0
TTEAFSANTDKNRYQDVPCQDKGRIVVKFPGLASDYIHANYLGTATN--PKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLE
..   ..   ||||.|.   |. |. ..     .||| |.|.    .  . |.|.|||||..| . || .  .. |  ..|...  | |. ||  |||  
ssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsv

QGQKLvfgEAPNTIsVANLGakKMAPDEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQ
....|   .|.. . |  |   ... . . . .| |.. . . || ..| |. .||| ||| 
vqerl...kagdvv.vefls..stsdefdrviltelqliyrsesrvvrhvqflswpdhGvps
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 72-333 2.8e-27 90.4 In-house 10-263 (267) alignment 
Range on Protein: 72-333
Range on HMM: 10-263/267.0
DEFRVLAKWTPEGMT--TEAFSANTDKNRYQDVPCQDKGRIVVKfpGLASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNcI
 ||  . | ...  |  .   . | ..||..|.   |. |....      .|| | |. .    ..||  |.||.||.  |. . ...||  ...| . .
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr..tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltk.v

ETGKIKchQYWPLEQGQKLVFGEapntISVANlGAKKMAPDEQCINVTtLKVDWgQGSRTIQHLQWENWPDRGVPQTNLTA---INLLSATRGNQNPILV
 |..|.  ..|| . ||   . .    ..|     .|   | | | .  ||.   . .. .    ...|      .  |     |         ..|..|
ftdnir..lfwPPkmgqakkyqd....ltveh.slekeendyqiitle.lkfkn.esahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

HCSAGIGRTGTIVAIaYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERY
.||.|.||.|| . | . | . .  |. . . ......|| |.  ..   .|.|.|..|  |   | 
acsdGvGrsGtflvi.dsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 146-329 9.3e-26 85.4 In-house 40-221 (255) alignment 
Range on Protein: 146-329
Range on HMM: 40-221/255.0
TQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANlgakkmAPDEQCINVTTLKVDWG--QGSRTIQHLQWENWPDRGV
|   |. . .| | | |.|||.  | |. ||..|.|||. .||.. .   ......      .  .  .   ..    |  .  .|..| ... |...  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladv..nvtttk......ssadvvlrtleitstlgekkkthtvkhysykGWiekna

PQTNLTAINLLSATRGNqNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENC-----MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
|.      |.| . |    ...||||.||||. . | . .|  ||.   .      .   .|..||||.|. .|.. .|  .   ..| ..
Pelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-330 1.5e-24 81.1 In-house 13-280 (303) alignment 
Range on Protein: 59-330
Range on HMM: 13-280/303.0
VQRTLDMGVQALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfpglASDYIHANYLGTATNpKKFICAQGPLENTQHSFWAMAIQEK
 .||||   .  |.||  .. . |  .. . |  | ||||. || | |. .. .      | ||||.||   .. || | .| ||  |   || | |..|
akrtldedaniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls....dssyihasyleldss.kkailtqlplshtaadfwqmiieqk

VECVIMLCNCIETGKIKCHQYWPLEQgQKLVFGEapNTISVANLGAKKMapdEQCINVTTLKVDWGQGSRTIQHLQWENWPDRGVPQT----NLTAI-NL
| ||..|    |  |.  .  .| .| . | | |   .| | ..   ..    .  ..  | |  |.    ..  ....||   .|       .  | .|
vkcvlllltdseydklggdsvfprnq.dflkfee..rsirvgefkrvel...gdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwql

LSATR--GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFL
 |  |   . .| .    .| ||.||.  .   .  . . .... .   .. .|  |  ..||  |. ... .|  . |
qsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_hpo-7_pd Subfamily hpo-7 145-335 1.2e-23 78.3 In-house 45-233 (263) alignment 
Range on Protein: 145-335
Range on HMM: 45-233/263.0
NTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApnTISVANLGAKKMAPDEQCINVTTLKvdwgQGSRTIQHLQWENWPDRGVP
.| ..|. .  | | | |.|||.  | |. || .|.|||. .|... .   ......   . .   .. ...   |    .  .|..| ..  |...  |
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanv..nvcttkvqsdvllktlellstlgeK....kkthtvkhysykgWiekndp

QTNLTAINLLSATRGNqNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENC-----MAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKE
.     .|.| ..|.   .. ||||.||||.   . .  |  ||.   .      .   .|..||||.|. .|.. .|  .   ..| ..|. . .
elareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfak
0048076 (Phosphotyrosine protein) phosphatases II 178-327 1.7e-23 78.3 In-house 1-141 (145) alignment 
Range on Protein: 178-327
Range on HMM: 1-141/145.0
QYWPLEQGQKLVFGEAPNTISVANLGAKKmapdeqCINVTTLKVDWGQGSRTIQHLQWENWPDRGVP---QTNLTAINLLSATRGNQNPILVHCSAGIGR
.||| |  ..| .|  |.......|   .         | .|  .    .|.. .... .|||.|||   .. |...... . . . .|.|||||||.||
pywpseilpglylgslptaldlellkdlg......ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgR

TGTIVAIAYVQDkmmagENcMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
|||.||.  .       .. . . | ....||.||....|. |. .|....| 
tgtlvaaylmll.....lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 68-335 2.5e-23 77.0 In-house 26-291 (302) alignment 
Range on Protein: 68-335
Range on HMM: 26-291/302.0
QALVDEFRVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRivVKFPGLASDYIHANYLGTATNPKKFICAQGPLENTQ---HSFWAMAIQEKVECVIM
. . .||  ...   .    .|| .|..||. .|||. |. .  || .. . .|..|  .      .. | || |  ...    .|| |. |||.  | .
aevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnl..vkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi

LCNCIETGKiKCHQYWPLEQGQKLVFGeapnTISVANLGAKKMAPDEQCINVTTLKVDWGQgSRTIQHLQWENWPDRGVPQTNLTAI----NL-LSATRG
|    |  |   ....|...|. . .|    .. | |   .|.  ...   .  |  .  . |  ..    .||..  ||.   ..|    ..  . . .
lvgeeelkk.tlselfpkksgdykeyg....kmfvNnrkVekaeeektryviEvlPegcsn.svlanvyvltnWkqkkvpvkyaeliktaakvfakkika

NQNpILVHCSAGIGRTGTIVAIAYVQDKMMAGeNCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSYFLERYKE
..| ...    |.|| |.... | . .|. .| .   ..|..| .|| || ....  ||  |...|| |.... ..
den.tvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
0048179 (Phosphotyrosine protein) phosphatases II 214-323 4.7e-22 73.7 In-house 34-139 (144) alignment 
Range on Protein: 214-323
Range on HMM: 34-139/144.0
INVTTlKVDWGQGSRTIQHLQWENWPDRGVP---QTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQdkmmagENCMAMNELIKELRSHRPW
||.|. . ..    |.. .... .|||.|||   .  |...... . . . .|.|||||||.|||||.||.  .       .. . ..| ....||.||.
inlte.eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpg

SIQNEFQYLYLHR
...|. |. .|..
avpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 90-254 4.2e-16 53.5 In-house 25-187 (319) alignment 
Range on Protein: 90-254
Range on HMM: 25-187/319.0
FSANTDKNRYQD-VPCQDKGRIVVKFPGLAS-DYIHANYL-GTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQ
  .  ||.|. . ||  .   .. . .   .  |..|.|. |    |  .|.|| .||..  .|| .  . .   .. |..  | |  .| .|.| ... 
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

K--LVFGEAPNTIsvanlgaKK-MAPDEQCINVTTLKVDWGQGSRTIQHLQWeNWPDRGVPQTNLTAINLL
.   ..|.   |.       |.  . |.  |    ||   .. || . |  . .|.. .||  . . | .|
dntslyGdilvtl.......kgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 95-181 2.7e-15 51.0 In-house 49-151 (350) alignment 
Range on Protein: 95-181
Range on HMM: 49-151/350.0
DKNRYQDVPCQDKGRIVVK----------FPGLASDYIHANYLGTA-----TNPK-KFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQ
 ||||...   .. |. .|              ..||| ||||  .      ||. |.| .|.|| .| . |. . .. ||. ...| . .| .  ||..
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWP
||.
YWq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 204-329 3e-15 50.5 In-house 68-194 (440) alignment 
Range on Protein: 204-329
Range on HMM: 68-194/440.0
AKKMAPDEQCINVTTLKvdwGQGSRTIQHLQWENWPDRGVPQTNLTAINLLSA-----TRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMN
  |  ||.. || . ..   |  |||... ... |||.|||.     ....        .  . |.||||||| |||| |.|.  .  .    .  . . 
evkgvpdsdyinasyin...giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsd.qidif

ELIKELRSHRPWSIQNEFQYLYLHRVLLSYF
 .|. .|. ||  .|   || ..| ..|  .
sfinsmrnnrpqmvqtpeqyafvheavlegl
PTEN_1 253-339 1.4e-12 42.8 In-house 119-190 (196) alignment 
Range on Protein: 253-339
Range on HMM: 119-190/196.0
LLSATRG---NQNPILVHCSAGIGRTGTIVAiAYvqdkMMAGENcMAMNELIKELRSHR-PWSIQnefqylylhrvllSYFLERYKETYAE
 .   .    |.| .|||| ||.||.||.|| ||    .|. .. . ..| .. .|..| |....             | ..||..| .||
sfiewllsdpngnvVlVHCkaGlgRsGtvva.ay....Lmykgk.ltadeAlelvrekRppgapn.............spsqerlleyfae
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 229-329 2.8e-12 41.0 In-house 216-344 (350) alignment 
Range on Protein: 229-329
Range on HMM: 216-344/350.0
TIQHLQWENWPDR---GVPQTNLTAIN--------LLS---ATRGNQNPILVHCSAGIGRTGTIVAIAYVQD-----KMMAGE-----NC----MAMNEL
 . .||..||.|      |.  |.|..        | .       ...|||||||||.|||||.|.. ..       ...  |             .. .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IKELRSHRPWSIQNEFQYLYLHRVLLSYF
..|||. |   .||  |.....  || ||
vnelrkqrismvqnldqfifiYeallfyf
subfamily_CG42327_pd Subfamily CG42327 251-328 2.8e-12 41.0 In-house 237-314 (319) alignment 
Range on Protein: 251-328
Range on HMM: 237-314/319.0
INLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLSY
|.  |.|| .| |. |||| |.||||...|      ..   .. . . .|.  .|  |  ....  || ....||  |
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
0038934 (Phosphotyrosine protein) phosphatases II 230-323 5.3e-12 41.3 In-house 80-171 (194) alignment 
Range on Protein: 230-323
Range on HMM: 80-171/194.0
IQHLQWENWPDRGVPQTNLT-----AINLLSaTRGNQNPILVHCSAGIGRTGTIVAIAYVQDkmmageNCMAMNELIKELRSHRPWSIQNEFQYLYLHR
|..|..    |  ||.....     ...     . ... ..||| ||.|||||.|| . ..       ..| ..| |. .|. || .|.|  .. .|..
ieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyr......lgmsaeeAialfrekRpgaipnqdyleallk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 115-180 7.8e-12 39.2 In-house 86-153 (349) alignment 
Range on Protein: 115-180
Range on HMM: 86-153/349.0
PGLASDYIHANYLGTA--TNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYW
 |   ||| ||||  .  .  ||.|. | ||  | . |. . . ..|. |. | .  |..  ||..||
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiyw
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 252-327 1.8e-10 35.2 In-house 219-293 (297) alignment 
Range on Protein: 252-327
Range on HMM: 219-293/297.0
NLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAGEnCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLLS
. | |    . ..|||||||.||.| .|    . .|.  .     .. ... ||. |.  .|   |. .|. . | 
eslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlk
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 134-315 1e-09 32.9 In-house 4-189 (198) alignment 
Range on Protein: 134-315
Range on HMM: 4-189/198.0
KKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVanLGAKkmaPDEQC-INVTTLKVDWGQGSRTIQH
...|..| || .|   || |  .     ..|. .     .     |||  .     .|    |  .  . .|   ||      . | ..     .| | |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittk...pdytitaliltnnttappstreish

LQWENWPDRGVPQTNLTaINLLSATR--------GNQNPILVHCSAGIGRTGTIVAIAY-VQDKMMAGENCMAMNELIKELRSHRPWSIQNE
 |.  | ..  |.  |  . .. |.|         .. |..|||| | | || .||.   |. .  .    . . |. | ||  |   |   
yqftswkekttpnvalf.vgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 134-315 1.2e-09 32.7 In-house 5-190 (199) alignment 
Range on Protein: 134-315
Range on HMM: 5-190/199.0
KKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEAPNTISVanLGAKkmaPDEQC-INVTTLKVDWGQGSRTIQH
...|..| || .|   || |  .     ..|. .     .     |||  .     .|    |  .  . .|   ||      . | ..     .| | |
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkt..ittk...pdytitaliltnnttappstreish

LQWENWPDRGVPQTNLTaINLLSATR--------GNQNPILVHCSAGIGRTGTIVAIAY-VQDKMMAGENCMAMNELIKELRSHRPWSIQNE
 |.  | ..  |.  |  . .. |.|         .. |..|||| | | || .||.   |. .  .    . . |. | ||  |   |   
yqftswkekttpnvalf.vgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiissl
DSPc Dual specificity phosphatase, catalytic domain 248-316 1.8e-09 32.6 Pfam-A 60-123 (133) alignment 
Range on Protein: 248-316
Range on HMM: 60-123/133.0
LTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAGENCmAMNELIKELRSHRPWSIQN-EF
  |.. ... . ... .|||| ||| |..|.. |||    .|  .|.  .|| .. ... |..  .| .|
eeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknl.slneAyefvkerrskispnagf
DSPc Dual specificity phosphatase, catalytic domain 248-316 1.8e-09 32.6 In-house 60-123 (133) alignment 
Range on Protein: 248-316
Range on HMM: 60-123/133.0
LTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAGENCmAMNELIKELRSHRPWSIQN-EF
  |.. ... . ... .|||| ||| |..|.. |||    .|  .|.  .|| .. ... |..  .| .|
eeavefiekaeqkgkkvlVHCqaGisRSatli.iaY....lmktknl.slneAyefvkerrskispnagf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 265-326 1.9e-09 31.8 In-house 2-62 (69) alignment 
Range on Protein: 265-326
Range on HMM: 2-62/69.0
LVHCSAGIGRTGTIVAIAyVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVLL
.||||.| |||||..||  |.   .  |  . . . .. .|  ||  . || .|...|  | 
vvhcssgtgrtgtfiaim.vemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 266-325 5.7e-09 30.2 In-house 2-60 (69) alignment 
Range on Protein: 266-325
Range on HMM: 2-60/69.0
VHCSAGIGRTGTIVAIAyVQDKMMAGENCMAMNELIKELRSHRPWSIQNEFQYLYLHRVL
||||.| ||||| .||  |.   .  |  . . . .. .|  ||  . || .|...|  |
vhcssGtGrtGtfiaim.vemarikseklvdifnnvqymrkcrpmmvmneneymfihdal
subfamily_PTPDC1_pd Subfamily PTPDC1 238-321 5.8e-09 30.6 In-house 90-168 (182) alignment 
Range on Protein: 238-321
Range on HMM: 90-168/182.0
WPDRGVP--QTNLTAINLLSATRGNQnPILVHCSAGIGRTGTIVAIAYVQDKMMAGEncmamnELIKELRSHRPWSIQNEFQYLYL
|.| ||.  .. |. . ... .  ..  . ||| || |||| ..|   |  | ...|      . || .||.|| |||   |   .
wkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltae......kaiklvrskrpksiqtreqvelv
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 70-178 1e-08 29.1 In-house 13-129 (347) alignment 
Range on Protein: 70-178
Range on HMM: 13-129/347.0
LVDEF-RVLAKWTPEGMTTEAFSANTDKNRYQDVPCQDKGRIVVKfPGL--------ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVE
|   |   ||...|  .|.  .  . .||| .||  .|. |.|.  |          .  || | ..      |..| .| || .|   || |    || 
lstyfdenlanyspskftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvt

CVIMLCNCIETGKIKCHQ
 |. . . |.   |.  .
qvvtifepikdeaieefa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 230-286 1.5e-08 28.4 In-house 220-290 (349) alignment 
Range on Protein: 230-286
Range on HMM: 220-290/349.0
IQHLQWENWPDRGV---PQTNLTAINLLS-----------ATRGNQNPILVHCSAGIGRTGTIVAIAYVQD
.  ||  ||.| ..   |.. |.|..  .               . ...||||||| ||||..| . .. .
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldllls
PTPc_motif_SM00404 225-319 1.9e-08 29.3 In-house 44-131 (140) alignment 
Range on Protein: 225-319
Range on HMM: 44-131/140.0
QGSRTIQHLQWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAGENCmAMNELIKELRSHRpWSIQNEFQYL
. ...| ... ..     . .    ... ... . ..  .|||| ||. |..|.. |||    .|  ...  ..| .. ... |  .|.  ....
nsgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatli.iaY....lmryrql.slaeayefvkerR.piispnlnfv
subfamily_DSP23_pd Subfamily DSP23 259-314 3.4e-08 28.3 In-house 82-131 (148) alignment 
Range on Protein: 259-314
Range on HMM: 82-131/148.0
GNQNPILVHCSAGIGRTGTIVAIAYVQDKMMAgencmaMNELIKELRSHRPWSIQN
 ... . |||  | |||||..|  .|. . .|        | | |.|  || |.. 
ekneavsvhcllgrgrtgtmlacylvkerkla......aaeaiaevrrlrpgsvet
subfamily_DSP10_pd Subfamily DSP10 234-309 1.1e-07 25.9 In-house 65-134 (159) alignment 
Range on Protein: 234-309
Range on HMM: 65-134/159.0
QWENWPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYVQDKMMagencMAMNELIKELRSHRP
. ..   . . |    |.. .   | ... .|||| ||| |  |.| |||.  ..      ...|.  |  .. ||
pvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvv.iaYlmkhln.....lslndaykfvkekrp
subfamily_DSP19_pd Subfamily DSP19 238-309 1.1e-07 26.3 In-house 66-131 (152) alignment 
Range on Protein: 238-309
Range on HMM: 66-131/152.0
WPDRGVPQTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYvqdkMMAgENCMAMNELIKELRSHRP
 |.  . .   .|.. .  .| ... .||||.||. |. ..| |||    .|. .. . ..| ....|..||
lpetdllsylkealdFieearskdgavlvHCnAGvSRsasvv.iay....lmk.keelsleealelvrearp
subfamily_CDC14_pd Subfamily CDC14 243-321 1.3e-07 25.8 In-house 246-318 (328) alignment 
Range on Protein: 243-321
Range on HMM: 246-318/328.0
VPQTNLTAiNLLSATRGNQNPILVHCSAGIGRTGTIVAIAYVQdkmmagENCMAMNELIKELRSHRPWSIQNEF-QYLYL
.|. ..   ..|...   .  | ||| ||.|||||..|   ..      .  .. .| |  ||  || |.     ..|. 
tPsdaivk.kfleiaekaeGaiavhCkaGLGrtGtLiacylmk......hyrftaaeaiawlricrPGsvigpqqkflee
subfamily_DSP6_pd Subfamily DSP6 249-290 4.6e-07 23.5 In-house 81-121 (158) alignment 
Range on Protein: 249-290
Range on HMM: 81-121/158.0
TAINLLSATRGNQNPILVHCSAGIGRTGTIVaIAYVQDKMMA
 ||...  .| ... .|||| ||| |. |.. .||.  |.. 
eaiefidearskkskvlvhClaGisrsvtvt.laylmkklal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 119-200 2.3e-06 22.0 In-house 13-87 (130) alignment 
Range on Protein: 119-200
Range on HMM: 13-87/130.0
SDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETgkikcHQYWPleQGQKLVFGEAPNTISVA
 .||.|...|   . .... .| || .|   || | ..  |. ...|    |       .|||  . . | . |   .....
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywp..dsePlewyeediivtlt
subfamily_eak_pd Subfamily eak 118-245 2.5e-06 21.1 In-house 77-196 (332) alignment 
Range on Protein: 118-245
Range on HMM: 77-196/332.0
ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETGKIKCHQYWPLEQGQKLVFGEApntisvaNLGAKKMaPDEQCINVT
   || |  .  .   .|.| .  . |.    || | ...|  ....| . .| .  |  .|.| .  ..| ||         ..  |.    .. ... 
rlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil.......dverkef.vkrniletr

TLKVDWGQGSRTIQHLQWENWPDRGVPQ
 |..  |  .  ..| .   | .  .|.
llelskGnethrvlhykvfGwtettlpk
subfamily_PTPMT1_pd Subfamily PTPMT1 249-314 2.5e-06 22.0 In-house 95-154 (171) alignment 
Range on Protein: 249-314
Range on HMM: 95-154/171.0
TAINLLSATRGNQNPILVHCSAGIGRTGTIVAiAYVqdkmMAGeNCMAMNELIKELRSHRPWSIQN
 ...... .. ... . ||| || ||..|.|| .|.    |   . . ..| .| |.. |.    .
kgvefiekvaskgkrvYvHCkaGrgRsatlva.cyl....mkk.eklspeeAlkalkkkRkiirla
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 118-199 3.3e-06 20.9 In-house 121-195 (244) alignment 
Range on Protein: 118-199
Range on HMM: 121-195/244.0
ASDYIHANYLGTATNPKKFICAQGPLENTQHSFWAMAIQEKVECVIMLCNCIETgkikcHQYWPleQGQKLVFGEAPNTISV
.  || | ..|      ..| .| || .|   || | .. .|. ...|    |       .|||  . . | . |   |...
gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp..dseplewyeeditvtl
subfamily_PRL_pd Subfamily PRL 260-320 5.5e-06 20.5 In-house 89-141 (151) alignment 
Range on Protein: 260-320
Range on HMM: 89-141/151.0
NQNPILVHCSAGIGRTGTIVAIAYVqdkmmagENCMAMNELIKELRSHRPWSIqNEFQYLY
... . ||| ||.||.  .||.| .       |. | ... .. .|..|  .| |. |  .
pkstvavhcvaGlGraPvlvalali.......eaGmkyedavefirekrrgai.nskqlkf
subfamily_DSP8_pd Subfamily DSP8 250-319 6.6e-06 19.8 In-house 82-144 (159) alignment 
Range on Protein: 250-319
Range on HMM: 82-144/159.0
AINLLSATRGNQNPILVHCSAGIGRTGTIvAIAYVQDKMMagencMAMNELIKELRSHRpWSIQNEFQYL
... .  .. ..  .|||. ||| |  |. ||||.  ..      |...|  . ....|  .|......|
svefidkaksengrvlvhvlaGisrsatv.aiayimktle.....msldeayrfvkekr.ptispnlnfl
subfamily_PTEN_pd Subfamily PTEN 260-309 6.9e-06 21.1 In-house 113-160 (184) alignment 
Range on Protein: 260-309
Range on HMM: 113-160/184.0
NQNPILVHCSAGIGRTGTIVAiAYVQDKMMAGENCMAMnELIKELRSHRP
..| . ||| || ||||.... ||.  ...  ..  |. || .| |..  
kknvvvvHCkaGkGRtGvliv.ayllkslllekaeeal.elfaeaRtknk
subfamily_DSP15_pd Subfamily DSP15 245-284 7.7e-06 20.1 In-house 62-100 (151) alignment 
Range on Protein: 245-284
Range on HMM: 62-100/151.0
QTNLTAINLLSATRGNQNPILVHCSAGIGRTGTIVAIaYV
.    ..... ..| ... .|||| ||. |  |.|.. |.
kffkesvefihkcRlkeenvlvhClaGvsRsvtlvva.Yl