Gene F54C8.4 in Caenorhabditis elegans

Synonym: CELE_F54C8.4, F54C8.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP096_AA protein Get Run
CeleP096_AA_16-187 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP11_pd Subfamily DSP11 8-186 4.1e-82 268.4 In-house 1-178 (178) alignment 
Range on Protein: 8-186
Range on HMM: 1-178/178.0
VPKDWSKFQPVGNVIPRTRFIVFKTPINSQLSTKIHKEQRFTTNDLFRQLSERGQYLGLVVDLSDTDRYYDKKDITGMCVQYEKVNCPGRGFiERDDCVE
||..|.|..|||. |..||||.||||.......|...|.|||..||...|.|....||||.||..|||||.||..| ..|.|.|.||||. . .....|.
vPdrwkkykpvgdkiegtrfiafktPlkesfdkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeelvk

SFHQVIQDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKAAKDKR
.|.........|..| |.|||||||.|.||.||||||.|||. |.....||.|||.|||.|.|. .|...|.|..|||.
kfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekdkk
0038934 (Phosphotyrosine protein) phosphatases II 8-192 7.7e-46 151.5 In-house 2-183 (194) alignment 
Range on Protein: 8-192
Range on HMM: 2-183/194.0
VPKDWSKFQPVGNVIPRtRFIVFKTPINSQLSTKIHKEQRFTTNDLFRQLSERGQYLGLVVDLSDTDRYYDKKDITGMCVQYEKVNCPGRGFIERDDCVE
.|..| |...||..|.  |||.||.|... | . |. ..||. .||.| |..... ||||.||. |.||||....... ..| |  .|..|..  .. . 
lPdrwlkyervgdiitg.rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

SFHQVIQDYTDKcdDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKAAKDKRDKQVDS
.| .........  ||. ...|||. |..| |.|....|| |||.| .|||. |...|. .|..  |. ||.|  |. |.... .
rfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrkavlap
subfamily_RNGTT_pd Subfamily RNGTT 9-189 1.3e-43 142.9 In-house 1-178 (189) alignment 
Range on Protein: 9-189
Range on HMM: 1-178/189.0
PKDWSKFQPVGNVIpRTRFIVFKTPINSQLSTKIHKEQRFTTNDLFRQLSERGQYLGLVVDLSDTDRYYDKKDITGMCVQYEKVNCPGRGFIERDDCVES
|. | .    |..|   .|. ||||. .. . .. .|.||... |.  |. ... ||||.||. |.|||||.... . ..| |..| |.|     . |..
PerWlnCPrkgkli.aekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvke

FHQVIQDYTDkcDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKAAKDKRDKQ
|....... .  . |. .|||||| | || |.||. .|...  || ..|...| .||   | |. |.  | .  .| ... 
fiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadveeai
0036282 (Phosphotyrosine protein) phosphatases II 10-180 7.5e-22 73.3 In-house 2-164 (174) alignment 
Range on Protein: 10-180
Range on HMM: 2-164/174.0
KDWSKFQPVGNVIPRTRFIVFKTPINsqlstKIHKEQRFTTNDLFRQLSERGQYLGLVVDLSDTDRYYdkkdITGMCVQYEKVNCPGRGFIERDDcVESF
.|. .  |.. ..  .|.|... | .      ..  ...  ..... |.|.   |... ..  ..|..     . . .|| ....|..|  . .  ...|
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsi.llef

HQVIQDYTDKcdDPDALIGVHCTNGINRCGYLICRFLIDRLGW-SSHEAIDAFEQAR---GYSIEKGAYVMALHK
 . ....  .  ||.  . |||. |..| |.|.. .|. |... |  .|.| . ..|   .....   . . |..
vkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
0040439 (Phosphotyrosine protein) phosphatases II 6-182 8.4e-21 70.1 In-house 27-242 (249) alignment 
Range on Protein: 6-182
Range on HMM: 27-242/249.0
RVVPKDWSKFQP--------VGNVIPRTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERGqyLGLVVDLSDTDRY---------------------
||. .....  .        .      .|||....| ..            |..| .|.| | |   . .|.|......                     
rvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe............tvedfwrmlwelg..itvivmLtslvelgrekcaqywplggsleygdft

----------------------YDKKDITGMCVQYekVNCPGRGFIERDDCVESFHQVIQDYTDKCdDPDALIGVHCTNGINRCGYLICRFLI-----DR
                      ||....| ...||  ...|  |  .  . . .| . .... ... ...  . |||..|..|.|..|. .|.      .
vtllsvevkddytvrtleltnlydgesrtvlhiqy..tdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqleke

LGWSSHEAIDAFEQARGYSIEKGAYVMALHKAA
||..  ||.. . ..|.....   . . |..|.
lgvdleeavkllrsqRpgavqnpeqyrflyeal
0043147 (Phosphotyrosine protein) phosphatases II 20-181 1.3e-19 66.0 In-house 15-156 (172) alignment 
Range on Protein: 20-181
Range on HMM: 15-156/172.0
NVIPRTRFIVFKTPinsqlstkihkeQRFTTNDLFRQLSERGQYLglVVDLSdtDRYYDKKDITGMCVQYEKVNCPGRGFIeRDDCVESFHQVIQDYTdk
 ..  .|||..  |             |.|..| .|.| |.|  .  .|.|   ...||... . . .||  ...|  |     . ...| . |...   
lyyipdrfiatqgp............lrntladfwrmlkelgith..ivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidell..

CDDPDALIGVHCTNGINRCGYLICRFLIDrLGWSSHEAIDAFEQARGYSIEKGAYVMALHKA
. .|.  . |||. |..| |.|.. .|.  ||.| .||.. . ..|.....   . . |.. 
alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyf
0041856 (Phosphotyrosine protein) phosphatases II 23-171 2.8e-19 64.9 In-house 32-156 (182) alignment 
Range on Protein: 23-171
Range on HMM: 32-156/182.0
PRTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERGqyLGLVVDLSdtDRYYDKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQdytdkcdd
| ||||....| .|            |..| .|.| |.|   ...|.|.  ...|. .. . . .|| ....|. |  . |....  ..|..        
patrfiatqgplls............tvadflrmlkelg..ittivnlt..eelywpellerlgiqylylpwpDhgvpdldelldfieevle........

PDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEK
..  . |||. |..| |.|.. .|. .||.|  ||.. . ..|  ... 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvit
0040438 (Phosphotyrosine protein) phosphatases II 22-186 9.3e-19 63.3 In-house 69-276 (317) alignment 
Range on Protein: 22-186
Range on HMM: 69-276/317.0
IP--------------RTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERgqYLGLVVDLSDTDRYY---------------------------DKK
 .              ...||....| ..            |..| .| . |    ....| | ... .                             ..
ldsdYInAsyvdgpnlkrkfIatqgPlpn............tvedFwrmvweq..gvtvivmLteleelgrekcaqYwplgetltygdftvtllseeela

DITGMCVQYEKVNC--------------PGRGFIERDDCVESFHQVIQDYTDkcdDPDALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAF
.||  ... |. ..              |  |. .  | . .| . .... .   ||.  . |||..|..|.|..|. .|.      . |..  ||.. .
gitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkel

EQARGYSIEKGAYVMALHKAAKDKR
 ..|.....  .. . |..|. .  
reqRpgavqtpeqyrflydalleyl
0042113 (Phosphotyrosine protein) phosphatases II 24-182 1.7e-18 62.4 In-house 51-239 (245) alignment 
Range on Protein: 24-182
Range on HMM: 51-239/245.0
RTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERGqyLGLVVDLSDTDRYYD-----------------------------------------KKDI
  .||..  | ..            |..| .|.| | |  .  .|.|.... .                                           ..| 
tpkfiatqgPlpe............tvedfwrmlwelg..ittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgdde

TGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKcdDPDALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAFEQARGYSIEKGAYVMA
. ....|  ...|. |  . .. ...|.. ....  .  |..  . |||. |..|.|..|. .|.      .||.|  ||.. . . |. ...   . . 
srevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrf

LHKAA
|..|.
lyeal
0044763 (Phosphotyrosine protein) phosphatases II 59-183 3.8e-18 61.2 In-house 46-168 (178) alignment 
Range on Protein: 59-183
Range on HMM: 46-168/178.0
ERGqyLGLVVDLSDTDRYY----DKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDkcdDPDALIGVHCTNGINRCGYLICRFLIDRLGWSS
| |  ....|.|.......    |... ... .|| ....|. |  . .. .. |.. |... |   ...  . |||. |..| |.|.. .|. .||.| 
elg..ithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglsl

HEAIDAFEQARGySIEKGAYVMALHKAAK
.|||. . ..|   ..   ..  |.. ..
eeaielvrerRp.ivpnpgqlrqLyefel
0045450 (Phosphotyrosine protein) phosphatases II 17-182 2.4e-17 59.1 In-house 99-300 (307) alignment 
Range on Protein: 17-182
Range on HMM: 99-300/307.0
PVGNVIPRTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERGqyLGLVVDLSDTDRYYD--------------------------------------
...  .  ..||....| ..            | .| .|.| | |   ...|.|.... . .                                      
lldgydlkrkfIatqgPlpe............tvedFwrmlweqg..vtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtle

-----KKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKCdDPDALIGVHCTNGINRCGYLICRFLIDRLG--------WSSHEAIDAFEQAR
     ... . .. ..   . |. |  .  . . .| . .... ... ...  . |||. |..|.|..|. .|. |..        ..  ||.. . . |
vtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR

GYSIEKGAYVMALHKAA
. ...   . . |..|.
pgavqnpeqyrflyeal
0049772 (Phosphotyrosine protein) phosphatases II 57-170 2.8e-17 58.9 In-house 167-259 (314) alignment 
Range on Protein: 57-170
Range on HMM: 167-259/314.0
LsergqylglvvdlsdtDRYYDKKDITGMCVQYEKVNCPGrGFIERDDCVESFHQVIQDYtdkcdDPDALIGVHCTNGINRCG-YLICRFLIDRLGWSSH
                 ...||... ... ..|  ...|. |    .. ...| ..|...     |..  . |||. |..| | .... .|. .||.| .
k................eelydpelferlgikylripvpD.gsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsle

EAIDAFEQARGYSIE
||.. . ..| ... 
ealedvrlkRpinpn
0037934 (Phosphotyrosine protein) phosphatases II 25-182 4.7e-17 57.8 In-house 44-238 (243) alignment 
Range on Protein: 25-182
Range on HMM: 44-238/243.0
TRFIVFKTPINSqlstkihkeqrfTTND----LFRQLSERgqYLGLVVDLSDTD----------------------------------------RYYDKK
 |.|..  | ..            |..|     .| | |     . .|.| ...                                        ...| .
prliatqgPlpe............tveddlasfwrmlwel..gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldld

DITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDK-----CDDPDALIGVHCTNGINRCGYLICRFLIDRL-GWSSHEAIDAFEQARGY-SIEKGA
| | . ..|  .. |. |  .  . . .|.. .... ..     ..|..  . |||. |..| |.||. .|. .| |..  ||.. . . |.. ...   
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtps

YVMALHKAA
. . |..|.
qyrflyeal
0049260 (Phosphotyrosine protein) phosphatases II 65-181 7.8e-17 56.8 In-house 33-145 (152) alignment 
Range on Protein: 65-181
Range on HMM: 33-145/152.0
GLVVDLSDTDRYYDKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYtdkCDDPDALIGVHCTNGINRCGYLICRFLIDrLGWSSHEAIDAFEQA
|  . .. |......|. . .  ||  ...|  |  . ..... ....|. .   . |..  . |||. |..| | |.. .|.  ||.|  ||.. . ..
gittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrek

RGYSIEKGAYVMALHKA
| ....   . . |.. 
Rpgavpnpgqlrflyef
0043336 (Phosphotyrosine protein) phosphatases II 24-181 1.4e-15 53.0 In-house 87-272 (278) alignment 
Range on Protein: 24-181
Range on HMM: 87-272/278.0
RTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERgqYLGLVVDLSDTDRYYD----------------------------------------KKDIT
 ..||....| ..            |..| .| . |       .|.| . . .                                          ... .
prkfiatqgPlpe............tvedFwrmvwel..gvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdges

GMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDkcdDPDALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAFEQARGYSIEKGAYVMAL
 ....|  .. |  |. |  . . .| ...... .   |..  . |||..|..|.|..|. .|.     ...|.. .||.. . . |. ...   . . |
rtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl

HKA
..|
yea
0048076 (Phosphotyrosine protein) phosphatases II 63-182 1.4e-15 52.7 In-house 29-139 (145) alignment 
Range on Protein: 63-182
Range on HMM: 29-139/145.0
YLGLVVDLsdtdrYYDKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKcddpDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFE
 ...|..|      ..... . . .||  ...|..|  .  . ...| . |... ..    .  . |||. |..| |.|.. .|. .||.| .||.. . 
gittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvr

QARGYSIEKGAYVMALHKAA
..| ....   ..  |... 
sqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 64-180 2e-15 52.3 In-house 30-139 (144) alignment 
Range on Protein: 64-180
Range on HMM: 30-139/144.0
LGLVVDLSDTdryYDKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDkcddPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQ
...|..|...   |.. . . . .|| ....|..|  .  . ...| . |... .    ..  . |||. |..| |.|.. .|. .||.| .||.. . .
ittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrs

ARGYSIEKGAYVMALHK
.| ....   ... |..
rrpgavpnpgqlrfLle
0039614 (Phosphotyrosine protein) phosphatases II 24-184 7.3e-15 50.7 In-house 100-287 (297) alignment 
Range on Protein: 24-184
Range on HMM: 100-287/297.0
RTRFIVFKTPINSqlstkihkeqrfTTNDLFRQLSERgqYLGLVVDLSDTDRY--------------------------------------YDkKDITGM
  .||....| ..            |..| .| . |       .| | ... .                                       . .. . .
trkfIatqgPlpe............tvedFwrmvweq..gvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrt

CVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKCdDPDALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAFEQARGYSIEKGAYVMALHK
. ..  .. |  |  .  . . .| . ....  .. ...  . |||..|..|.|..|. .|.      . |..  ||.. . ..|.....   . . |..
vthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd

AAKD
|...
alle
DSPc Dual specificity phosphatase, catalytic domain 65-175 1.1e-13 46.2 Pfam-A 20-124 (133) alignment 
Range on Protein: 65-175
Range on HMM: 20-124/133.0
GLVVDLSDTDRY---YDKKDITGMCVQYEKvncpgrgfIERDDCVESFHQVIqDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAF
 ||...... .    . |..|. .... |          . .. .. . ... .. .|...    . |||. ||.| ..||...|... ..|. ||....
tlvinvtkevpnnnaikkseieylripved........etetkiskeleeav.efiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv

EQARGYSIEKGAYV
.. |.   ..  ..
kerrskispnagfl
DSPc Dual specificity phosphatase, catalytic domain 65-175 1.1e-13 46.2 In-house 20-124 (133) alignment 
Range on Protein: 65-175
Range on HMM: 20-124/133.0
GLVVDLSDTDRY---YDKKDITGMCVQYEKvncpgrgfIERDDCVESFHQVIqDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAF
 ||...... .    . |..|. .... |          . .. .. . ... .. .|...    . |||. ||.| ..||...|... ..|. ||....
tlvinvtkevpnnnaikkseieylripved........etetkiskeleeav.efiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefv

EQARGYSIEKGAYV
.. |.   ..  ..
kerrskispnagfl
0051082 (Phosphotyrosine protein) phosphatases II 51-170 5.5e-13 44.3 In-house 23-137 (151) alignment 
Range on Protein: 51-170
Range on HMM: 23-137/151.0
NDLFRQLseRGQYLGLVVDLSDTD------RYYDKKDITGMCVQYEKVNCPGrgfierddcVESFHQVIQDYT----DkcdDPDALIGVHCTNGINRCGY
.| ...|  . . .  .|.| ...      .|. . .|. ......    ||         .. . . ....     |   ...  . |||. |..| | 
adflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpg.........lplsfdavleflellld...kkngpvlvHCsaGkgRTGt

LICRFLIDrLGWSSHEAIDAFEQARGYSIE
|.. .|.  ||.|  ||.. . . |.... 
lvalylml.lgvsleealeeyrlkrpgvvq
0046846 (Phosphotyrosine protein) phosphatases II 49-182 2.6e-12 42.4 In-house 35-169 (176) alignment 
Range on Protein: 49-182
Range on HMM: 35-169/176.0
TTNDLFRQLSERGqyLGLVVDLSDTD------RYYDKKDITGMCVQYEKVNCPGRGFIERdDCVESFHQVIQDYTDKcddpDALIGVHCTNGINRCGYLI
|. | ...| | |   ..||.| .         ... ...... .||  .. |  |  .  . .... . |... ..    .  . |||  ||.| | |.
tladflemlkelg..itavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealke....ggpvlVHCsaGigRtgtlv

CRFLIDR-LGWSSHEAIDAFEQARG-YSIEKGAYVMALHKAA
. .|. .  |.| .||.. . . |  ....  ...  |....
aayllelekglsveealalvreqRplgavqtpeQyrflyefe
PTPc_motif_SM00404 88-181 2.9e-12 41.6 In-house 46-137 (140) alignment 
Range on Protein: 88-181
Range on HMM: 46-137/140.0
QYEKVNCPgRGFIERDDCVESFHQVIqDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARgYSIEKG-AYVMALHKA
... ...|     | |. .. . .|. |. ... .    . |||. |..| ..||. .|... ..| .||...... |  .|..   .|  |.. 
gfqilqip.lddnekdklskyldkvl.dfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR.piispnlnfvrqLiey
0045098 (Phosphotyrosine protein) phosphatases II 18-183 1.1e-11 40.1 In-house 31-269 (278) alignment 
Range on Protein: 18-183
Range on HMM: 31-269/278.0
VGNVI---------------------------PrTRFIVFKTPINsqlstkihkeqrFTTNDLFRQLSERGqyLGLVVDLSDTD----------------
.||.                            | ..||..  | .             |..| .|.| | |     .| | .                  
lgnldknRykdilpydhsrVkdYINAsyidgyp.kkfIatqgPlp............stvadfwrmlwelg..itvivmltelvelgrekcaqywpeggs

----------------------------RYYDKKDITGMCVQYEKV-NCPGRGFIERD--DCVESFHQVIQDYTD----------KCDDPDALIGVHCTN
                             .. ..|.. . |.. .  . |  |  . .  . . .. . |... .           ..|..  . |||  
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GINRCGYLICRFLIDRL---GWSSHEAIDAFEQARGY-SIEKGAYVMALHKAAK
|..| | |.. .|. .|   |..  ||.. . . |.. ...     . |.... 
GvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0048567 (Phosphotyrosine protein) phosphatases II 103-170 1.4e-11 39.0 In-house 53-137 (157) alignment 
Range on Protein: 103-170
Range on HMM: 53-137/157.0
DDCVESFHQVIQDYTDKCDDPDALIGVHCTNGI---NRCGYLICRFLIDRLGWSSHEAIDAFEQARG--------------YSIE
 ... .| ... .. . ..  .  | |||. |     |...||. .|| .||.. .|||. . ..|               |.. 
lailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynlt
0046845 (Phosphotyrosine protein) phosphatases II 78-182 4.5e-11 38.1 In-house 159-270 (284) alignment 
Range on Protein: 78-182
Range on HMM: 159-270/284.0
DKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKcDDPDALIGVHCTNGINRCGYLICRFLIDRL--------GWSSHEAIDAFEQARGYSI
. .. . .. ..   . | .|  .  . . .| . .... ..  ...  | ||| .|..| |..|.  |. ..        |..  ||.  . . | ...
gytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv

EKGAYVMALHKAA
.  .  . ...|.
qtleqyrfvyeal
0050432 (Phosphotyrosine protein) phosphatases II 81-182 5e-10 34.7 In-house 194-295 (308) alignment 
Range on Protein: 81-182
Range on HMM: 194-295/308.0
DITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTdkcddPDALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAFEQARGYSIEKGAYV
. . .. ..   |.|  |  .  . . .| . ....      |.  | ||| .|..|.| .|.  |.        |..  ||.  . . | ....   . 
gesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqy

MALHKAA
. |..|.
lflyral
0051299 (Phosphotyrosine protein) phosphatases II 76-182 7.3e-10 34.2 In-house 174-282 (288) alignment 
Range on Protein: 76-182
Range on HMM: 174-282/288.0
YYDKKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDkcdDPDALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAFEQARGYSIE
..|... . .. ..   | |  |. .  . . .| . ....     ...  . ||| .|..|.| .|. .|.      . |..  ||.  . . | ....
lldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvq

KGAYVMALHKAA
     . ...|.
tpeqyrfvyeal
PTEN_1 64-166 1e-09 33.5 In-house 70-172 (196) alignment 
Range on Protein: 64-166
Range on HMM: 70-172/196.0
LGLVVDLSDTD--RYYDKKDITGMCVQYEKVNCPGRGfIERDDCVESFHQVIQDYTDKCDDpDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAF
| . ... . .  | ||...   . |.| ..  .  |     ...  .  .. ..  ....    . |||. |..|.| ... .|. . ... .||.. .
lvvnlseeeelsgrsydleeffksgveylhfpieDhg.apslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelv

EQARG
 ..| 
rekRp
0051429 (Phosphotyrosine protein) phosphatases II 60-189 2.1e-09 33.0 In-house 42-228 (272) alignment 
Range on Protein: 60-189
Range on HMM: 42-228/272.0
RGQYLGLVVDLSDTDRYYDKK-DITGMCVQYEKVNCPGRGFIERD---------------------------------------------------DCVE
. . .  .||| ... .   | |     ..|  ........ .                                                     . . 
kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeall

SFHQVIQDytdkcddpDALIGVHCTNGINRCGYLICRFLIDrLGWS--------------SHEAIDAFEQARGYSIEKGAYVMALHKAAKDKRDKQ
.. ....|        .  . |||. |..| | ... .|.  ||.|                ||..   ..| ....  . .. |..|...  .. 
ellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0047943 (Phosphotyrosine protein) phosphatases II 79-181 3.1e-09 32.2 In-house 161-267 (273) alignment 
Range on Protein: 79-181
Range on HMM: 161-267/273.0
KKDITGMCVQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKCDDPdALIGVHCTNGINRCGYLICRFLI-----DRLGWSSHEAIDAFEQARGYSIEKGA
. . . .. ..   . |  |  .  . . .| ......  .. ..   . ||| .|..| | .|. .|.      . |..  ||.  . . | ....   
gtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpe

YVMALHKA
. . |..|
qyrflyea
0036941 (Phosphotyrosine protein) phosphatases II 103-181 1.9e-08 29.5 In-house 180-272 (297) alignment 
Range on Protein: 103-181
Range on HMM: 180-272/297.0
DDCVESFHQVIQDYTDKCDD------PDALIGVHCTNGINRCGYLICRFLI--------DRLGWSSHEAIDAFEQARGYSIEKGAYVMALHKA
|..| . .. . |. .....      ..  . ||| .|..|.| .|. .|.         . |..  ||.  . . |  ...     . |. |
dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
subfamily_PTEN_pd Subfamily PTEN 39-167 3.9e-08 28.5 In-house 36-158 (184) alignment 
Range on Protein: 39-167
Range on HMM: 36-158/184.0
STKIHKEQRFTTNDLFRQLSERGQYLGLVVDLSdTDRYYDKKDITGMCVQYEKVNCPGRGFierdDCVESFHQVIQDYTDKcdDPDALIGVHCTNGINRC
..|...  | ...|... | .. .    . .|  ..|.||.|...|.  .|.  .     .    . .|.. . |... ..  |.. .. |||  |  | 
aeklealyRnsledvvkflekkhkdhykiynlr.serkydskkfdgrvavypfdDhnpppl....elleeivediekwlee..dkknvvvvHCkaGkGRt

GYLICRFLIDRLGWSSH-EAIDAFEQARGY
| ||. .|. .| .... ||.. |..||  
GvlivayllkslllekaeealelfaeaRtk
subfamily_DSP1_pd Subfamily DSP1 102-180 4.5e-07 24.1 In-house 74-151 (163) alignment 
Range on Protein: 102-180
Range on HMM: 74-151/163.0
RDDCVESFHQVIqDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALHK
..|  . |..|| .. |.. . .  . .||  || |   |.  .|. .  .| .|| |   | |  .    ..|  | .
kadislvfeevi.efidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLln
PTPc_DSPc_SM00012 87-162 6.2e-07 24.9 In-house 3-77 (105) alignment 
Range on Protein: 87-162
Range on HMM: 3-77/105.0
VQYEKVNCPGRGFIERDDCVESFHQVIQDYTDKCDDpDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFE
 .|.  ..|  |  |. | . .. . ... . |...  . . ||| .|..|.|....  .. .  ..... .| |.
khyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifq
subfamily_CDC14_pd Subfamily CDC14 25-165 1.3e-06 22.5 In-house 178-304 (328) alignment 
Range on Protein: 25-165
Range on HMM: 178-304/328.0
TRFIVFKTPINSQLSTK-IHKEQRfttNDLFRQLSErgQYLGLVVDLSDTdrYYDKKDITGMCVQYEKVNCpGRGFIERddcvesfHQVIQDYTDKCDDP
 .|. .  | | .  ..  ....    . |..   .  . .  || |      ||.|  | . .... .     | .         ..... ... ... 
dkflalagPhnkskledgyplhaP...eklleyfrk..nnvttvvrLnkk..lYdakkftdaGfdhkDlff.iDGstPs.......daivkkfleiaeka

DALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQAR
.  | |||  |. | | ||  .|. . . .. |||  .  .|
eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricr
subfamily_DSP12_pd Subfamily DSP12 105-167 3.8e-06 21.4 In-house 64-125 (155) alignment 
Range on Protein: 105-167
Range on HMM: 64-125/155.0
CVESFHQvIQDYTDKCDDPDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGY
 .. . . . |. ... . .  . |||. |. |   ..  .|. . ..| ..|... ....  
iLshlde.avdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpe
subfamily_PRL_pd Subfamily PRL 75-170 4.5e-06 20.8 In-house 49-135 (151) alignment 
Range on Protein: 75-170
Range on HMM: 49-135/151.0
RYYDKKDITGMCVQYEKVNCPgrgfieRDDCVESFHQVIQDYTdkCDDPDALIGVHCTNGINRCGYLICRFLIDRlGWSSHEAIDAFEQARGYSIE
.  .|..|. . ....  . |       .. ||.. .....    ...|.. ..|||  |. |.  |..  ||.  | ....|..   . |  .|.
eklekegievldlafddGavP......peevveeWlellkekf..keepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefirekrrgain
subfamily_PTPDC1_pd Subfamily PTPDC1 126-179 4.5e-06 21.2 In-house 116-169 (182) alignment 
Range on Protein: 126-179
Range on HMM: 116-169/182.0
LIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEKGAYVMALH
 ..|||  |  | | ||. .|.     ....||.   . |  ||.    |  ..
kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvk
subfamily_DSP23_pd Subfamily DSP23 104-171 4.8e-06 21.3 In-house 68-131 (148) alignment 
Range on Protein: 104-171
Range on HMM: 68-131/148.0
DCVESFHQVIQDYTDKcddpDALIGVHCTNGINRCGYLICRFLIDRLGWSSHEAIDAFEQARGYSIEK
. |. | .|...  .|    .  ..|||  |  | | ..  .|.   . .. |||    . |  |.| 
eqvvefvrvveeaeek....neavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet