Gene F54F12.1 in Caenorhabditis elegans

Synonym: CELE_F54F12.1, F54F12.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP097_AA protein Get Run
CeleP097_AA_864-1132 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 849-1145 8.2e-164 538.3 In-house 7-302 (302) alignment
Range on Protein: 849-1145
Range on HMM: 7-302/302.0
LCTKSPQEWAEGIYDTIWKLDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGEISWIMAQGPMDGTEHLEKISKVPPKPKKSTLEK
|     .|. | .. ...||....|||....||.||..||.||||||||||.|...||||||.|..||.||||||||||||..||.||.|..||||||||
lnktlleefleyveraleklkkktstnlekdiserrkslficepktmaklvdfkndfinanvlkldeikwimaqGpmdGtekkekvskkpivpkkstlek

HWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMYNLEYKNDQWQDkKLKKTVSVLHFTAWPDHGAPK
|||.|.||.|.||.||.|..|....|.|.|||.|||....||||||.|.|..|.||.|||||||..|..|.||..... |.||||..|.|.|||||||||
hwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafsawpdhGapk

NPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEGVLYWRSFDA
....||||..||||||..|||||||||||||||||||||||||.....|.|||||.|||.||.||||..|||.||..|.|||.|.|.||||.|||||
eaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekagvlylrsfda

Y_phosphatase Protein-tyrosine phosphatase 879-1128 2.3e-64 212.4 Pfam-A 1-234 (235) alignment
Range on Protein: 879-1128
Range on HMM: 1-234/235.0
NISQRRHTLFLCEPKTMAKLVGFPD--PFINANVM---KfGEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVIESDDR
| ...|.. .|.  ||. || | ..   .||||..   |  . ..|..|||.                 |||.|..|... |..| ....|.|. |....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPl.................kstiedFWrmvwqekvkvivmltsleekgre

KFAPYYSEKVGEKMTFGRYTVTTKsintkLENFTDKKSFVMYNLEYKNDQWQDkkLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK----TSVLV
|.|.|..|. .|..|.|...|..|      .. .|.|......||.|......   |..|..||.|.|||||.|..|.  ||.|| .|..|    ..|.|
kcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvV

HCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
|||||||||||.||... .. ...|.....|.||. .|..|.|.|||..|...|. .|.
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 879-1128 2.3e-64 212.4 In-house 1-234 (235) alignment
Range on Protein: 879-1128
Range on HMM: 1-234/235.0
NISQRRHTLFLCEPKTMAKLVGFPD--PFINANVM---KfGEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVIESDDR
| ...|.. .|.  ||. || | ..   .||||..   |  . ..|..|||.                 |||.|..|... |..| ....|.|. |....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPl.................kstiedFWrmvwqekvkvivmltsleekgre

KFAPYYSEKVGEKMTFGRYTVTTKsintkLENFTDKKSFVMYNLEYKNDQWQDkkLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK----TSVLV
|.|.|..|. .|..|.|...|..|      .. .|.|......||.|......   |..|..||.|.|||||.|..|.  ||.|| .|..|    ..|.|
kcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvV

HCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
|||||||||||.||... .. ...|.....|.||. .|..|.|.|||..|...|. .|.
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0036941 (Phosphotyrosine protein) phosphatases II 873-1143 5.4e-56 185.4 In-house 33-289 (297) alignment
Range on Protein: 873-1143
Range on HMM: 33-289/297.0
STNTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGE--ISWIMAQGPMDgtehlekiskvppkpkkSTLEKHWAVIDQYDVGIVAQLASVIES
 .. ..|..  |.. .|. ..|. || . .. .|||. ... .    .|..|||..                 .|.|..|  . ...| ..  | ...| 
vallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp.................ntvedFWrmvweqnvtvIvmltelvel

DDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKlenftDKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES------YK
.  |.|.|.....|| .|.|..|||..|....     .........|| ..    ... ..|| ..|.| |||||.| .|.. ||.|.....       .
grekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TSVLVHCSAGVGRTGTLVAIKYGIQLCT---TERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEGVLYWRSF
. |||||||||||.||..|. . .|.     .|.. ..|..|. .|..|.||||. .|...|. .. . .. |. .......
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl

0040438 (Phosphotyrosine protein) phosphatases II 867-1140 6.8e-55 181.9 In-house 31-285 (317) alignment
Range on Protein: 867-1140
Range on HMM: 31-285/317.0
KLDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFP----DPFINANVMKFG--EISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGI
||| .  .. ..|.. .|.. .|. . .  ||  ..    . .|||. ...      .|..|||.                 ..|.|..|  . ...|..
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.................pntvedFwrmvweqgvtv

VAQLASVIESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFC
.  | .  | ...|.|.|...  ||..|.|..|||..|. .       ........|| ...   ... . || ..|.|.|||||.|..||  ||.....
ivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfleav

ESY----KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEGVLYW
...    .. ||||||||||||||..|. . .... .|.. .. ..|. .|..| ||||. .|...|. .. . .. |.   ..
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa

0050432 (Phosphotyrosine protein) phosphatases II 871-1132 1.6e-53 177.4 In-house 60-300 (308) alignment
Range on Protein: 871-1132
Range on HMM: 60-300/308.0
MVSTNTQANISQRRHTLFLCEPKTMAKLvGFPDPFINANVMKFG----EISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLAS
. ... ..|..  |.. .|.  ..  || . .. .|||. ...     .  .|..|||.                 ..|.|..|  . ...| ..  | .
ysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPl.................pntvedFwrmvweqnvrvIvmLtk

VIESDDRKFAPYYSEKVG-EKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWQDKklkKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY--
 .| .  |.|.|. ...| . ...|..|||..|. .       ........|| .| . ..    .|| ..|.|.|||||.| .|.  ||........  
lvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdges...rtvthfhytnWpdhgvPpspeilldflelvrkslp

KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
.  ..||||||||||||..|. . ...  .|.. .....|. .| .| |.||. .|...|. .. . ..
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

DSPc_SM00195 872-1129 1.9e-52 173.5 In-house 19-260 (263) alignment
Range on Protein: 872-1129
Range on HMM: 19-260/263.0
VSTNTQANISQRRHTLFLCEPKTMAKLVGF----PDPFINANVMKF--GEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLA
 ... ..| |. |.. .|.  .|  ||       .. .||||..|.   . ..|..|||.                 .||.|..| .. . .| |.. | 
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.................pstvedFWrmvweekvkiivmlt

SVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLenftdkKSFVMYNLEYKNDQWqdkKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT
.  |.. .| . |. |. |.|.|||...|.... ..|       .......||.....    . ...| ......|||||.|..... |...|.... | 
eeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksks

----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
     ..||||||||||||.|.|.. .. ...| . .. .||. .|. |.|.||. .|..... .| .
tssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 872-1129 1.9e-52 173.5 In-house 19-260 (263) alignment
Range on Protein: 872-1129
Range on HMM: 19-260/263.0
VSTNTQANISQRRHTLFLCEPKTMAKLVGF----PDPFINANVMKF--GEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLA
 ... ..| |. |.. .|.  .|  ||       .. .||||..|.   . ..|..|||.                 .||.|..| .. . .| |.. | 
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.................pstvedFWrmvweekvkiivmlt

SVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLenftdkKSFVMYNLEYKNDQWqdkKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT
.  |.. .| . |. |. |.|.|||...|.... ..|       .......||.....    . ...| ......|||||.|..... |...|.... | 
eeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksks

----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
     ..||||||||||||.|.|.. .. ...| . .. .||. .|. |.|.||. .|..... .| .
tssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0047943 (Phosphotyrosine protein) phosphatases II 871-1127 2.1e-51 170.3 In-house 30-268 (273) alignment
Range on Protein: 871-1127
Range on HMM: 30-268/273.0
MVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKF--GEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVI
.  .. ..|..  |.. .|.  ... || . .. .|||. ...   .  .|..|||.                 ..|.|..|  . ...| ..  | ...
ysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl.................pntvedfwrmvweqnvrviVmLtelv

ESDDRKFAPYYSEKVGE-KMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWQDkklKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----
| . .|.|.|.....|| ..|.|..|||..|..|       |.......|| .| . ..   ..|| ..|.| |||||.| .... |..|.....     
elgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkaleal

-YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
  .. |.||||||||||||..|. . ...  .|.. ..|..|. .|..|.|.||. .|...|. ..
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal

0039614 (Phosphotyrosine protein) phosphatases II 869-1131 9.3e-51 168.4 In-house 47-289 (297) alignment
Range on Protein: 869-1131
Range on HMM: 47-289/297.0
DvMVSTNTQANISQRRHTLFLCEPKTMAKLVGFP-----DPFINANVMKFGEI---SWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGI
| .. .. ..|.. .|.. .|. . .. || ...     . .|||. ... ..    .|..|||...                 |.|..|  . ...| .
d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.................tvedFwrmvweqgvtv

VAQLASVIESDDrKFAPYYSEKVGekmTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNdqwqdKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFC
.  | . .| .  |.|.|..|..|   |.|..|||.... .       .. .....|| .|     ..  .|| ....| |||||.| .... |......
ivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn.....ngesrtvthfqytgwpdhgvppslellleflelv

ES------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGV
..       .. ||||||||||||||..|. . .... .|.. ..|..|. .|..| ||||. .|...|. .. . .
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

0045450 (Phosphotyrosine protein) phosphatases II 871-1127 2.5e-50 167.3 In-house 47-300 (307) alignment
Range on Protein: 871-1127
Range on HMM: 47-300/307.0
MVSTNTQANISQRRHTLFLCEPKTMAKLVG-----FPDPFINANVMKF----------GEISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQ
. ... ..|.. .|.. .|. . |  ||        .. .|||. ...              .|..|||...                 |.|..|  . .
ysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.................tvedFwrmlwe

YDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwQDKKLKKTVSVLHFTAWPDHGAPKNPDYALD
..|...  | . .| ...| |.|.... ||..|.|..|||..|...       ........|| ..   . ..   || ..|.|.|||||.|.... .||
qgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......ldgytvrtlevtdl..dgtgesrtvthfhytgwpdhgvppsfeelld

IIRFCES------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERT---TNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
.|. ...       .. ||||||||||||||..|. . ...  .| |    .||..|. .|..| ||||. .|...|. ..
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal

0046845 (Phosphotyrosine protein) phosphatases II 869-1132 4.5e-50 166.0 In-house 18-275 (284) alignment
Range on Protein: 869-1132
Range on HMM: 18-275/284.0
DVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDP-----FINANVMKFG-------EISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQY
  .  .. ..|.|  |.. .|.  ..  ||  ...      .|||. ...        .  .|..|||...                 |.|..| .. ..
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.................tvedFwrmvweq

DVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDI
.| ..  | . .| .  |.|.|.... ||..|.|..|||..|...       |.......|| .|   . ..  .|| ..|.|.|||||.| .|.  |..
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedllef

IRFCESY------KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTER---TTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
.|.....      .  ..||||||||||||..|. . ...  .|.   . ..|..|. .|..|.|.||. .|..... ..   ..
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

0051299 (Phosphotyrosine protein) phosphatases II 872-1128 2.4e-49 163.7 In-house 42-283 (288) alignment
Range on Protein: 872-1128
Range on HMM: 42-283/288.0
VSTNTQANISQRRHTLFLCEPKTMAKLVG----FPDPFINANVMKF--GEISWIMAQGPMDgtehlekiskvppkpkkSTLEKHWAVIDQYDVGIVAQLA
 ... ..|..  |.. .|.  ..  ||       .. .|||. ...   .  .|..|||..                 .|.|..|  . ...| ..  | 
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp.................ntvedFWrmvweqnvrvIvmlt

SVIESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQ-WQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY-
...| . .|.|.|...  |...|.|..|||..|. .       ........|| .| . .. .. ..|| ..|.|.|||||.| .|.  ||..|.. .. 
klvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

---KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
   .  |.||||||||||||..|. . ...  .|.. ..|..|. .|..|.|.||. .|..... .. 
asgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall

0045098 (Phosphotyrosine protein) phosphatases II 877-1130 2.4e-47 157.0 In-house 31-271 (278) alignment
Range on Protein: 877-1130
Range on HMM: 31-271/278.0
QANISQRRHTLFLCEPKTMAKlvgfpDpFINANVMKFGEISWIMAQGPMDgtehlekiskvppkpkkSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFA
  |..  | . .|. . .. |     | .|||. ...    .|..|||..                 ||....|  . .... ..  |....| .  |.|
lgnldknRykdilpydhsrVk.....d.YINAsyidgypkkfIatqgPlp.................stvadfwrmlwelgitvivmltelvelgrekca

PYYSEkvGEKMTFGRYTVTTKSINTKleNFTDKKSFVMYNLEYKNDQWQdkklKKTVSVLHFTAWPDHGAPKNP--DYALDIIRFCES------------
.|. |  |. .|.|..|||..|. .   .   .  . ..|| ..   ..    . .| .||.. |||||.| .|  .. |....|...            
qywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredle....srgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCttERTTNLLSIVCPVRNCRFG-AVQSAQQLMYLIVCITKG
      .. |||||||||||||||||. . ..|.  |.. .||..|. .|..| | |||. .|...|. .. . 
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel

0043336 (Phosphotyrosine protein) phosphatases II 865-1127 3.9e-47 156.4 In-house 33-273 (278) alignment
Range on Protein: 865-1127
Range on HMM: 33-273/278.0
IWklDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFP----DPFINANVMKFG--EISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDV
 .  | .  .. ..|.. .|.. .|. . .. ||  ..    . .|||. ...      .|..|||...                 |.|..|  . ...|
kl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.................tvedFwrmvwelgv

GIVAQLASVIESDDRKFAPYYSekvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNdqwQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIR
 ..  | .  | .  |.|.|..   |. .|.|..|||......       .. .....|| .|     .. ..|| ..|...|||||.| ...  ||...
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpeslsllldflk

FCES----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
.  .     .. ||||||||||||||..|. . ...  .|.. .|...|. .|..|.||||. .|...|. ..
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

0040439 (Phosphotyrosine protein) phosphatases II 874-1127 4e-47 156.3 In-house 6-242 (249) alignment
Range on Protein: 874-1127
Range on HMM: 6-242/249.0
TNTQANISQRRHTLFLCEPKTMAKLVG----FPDPFINANVMKF--GEISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGIVAQLASV
.. ..|.. .|.. .|. . .. ||      |.. .|||.....      .|..|||...                 |.|..|  . .......  | | 
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.................tvedfwrmlwelgitvivmLtsl

IESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----
 | .  |.|.|...  |. ...|..|||..|...       |.......|| .|     .. . || ....| |||||.|.... .||.|. ...     
velgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel

-YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
  .. ||||||||||||||..|. . ...  .|.. .|...|. .|..|.||||. .|...|. ..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal

0042113 (Phosphotyrosine protein) phosphatases II 875-1127 3.3e-45 149.8 In-house 5-239 (245) alignment
Range on Protein: 875-1127
Range on HMM: 5-239/245.0
NTQANISQRRHTLFLCEPKTMAKLVGFP----DPFINANVMKFGEI--SWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGIVAQLASVI
. ..|.. .| . .|. . |. ||   .    ...|||. ... .|   .|..|||...                 |.|..|  . .... ..  | .  
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.................tvedfwrmlwelgittivmLteee

ESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----Y
| .  |.|.|...  ||..|.|..|||..|...       ........|| .|.    .. ...| ..|.. |||||.| .... ||...|...      
elgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
.. ||||||||||||||..|. . ...  .|.. .| ..|  .|..| ||||. .|...|. ..
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

0037934 (Phosphotyrosine protein) phosphatases II 875-1127 2.6e-42 140.4 In-house 6-238 (243) alignment
Range on Protein: 875-1127
Range on HMM: 6-238/243.0
NTQANISQRRHTLFLCEPKTMAKLVGfpDPFINANVMKFGEiSWIMAQGPMDGTEHLekiskvppkpkksTLEKHWAVIDQYDVGIVAQLASVIESDDRK
. ..|.| .|.. .|. . .. || |  . .|||| ..  .  .|  |||...| .              .|...|  . .......  | . .| .  |
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.rliatqgPlpetved.............dlasfwrmlwelgitvivmltelvElgrek

FAPYYSekvGEKmTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWQDKKlkKTVSVLHFTAWPDHGAPKNPDYALDIIRFCE------------S
 |.|..   ||. |.|..|||..|...       ........|...| ...| .  ..|  .|...|||||.| .|.  ||.....             .
caqywp...gev.tygdftvtllseeh.......lddytvrtlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllald

YKTSVLVHCSAGVGRTGTLVAIKYGIQLCtterTTNLLSIVCPVRNCRFG-AVQSAQQLMYLIVCI
 .  |||||||||||||||.|. . ..|.    . .|...|. .|..|.| |||. .|...|. ..
sggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal

subfamily_PTPN12_pd Subfamily PTPN12 941-1131 5e-33 109.2 In-house 91-277 (290) alignment
Range on Protein: 941-1131
Range on HMM: 91-277/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSintklENFTDKKsFVMYNLEYKNDqwqdkKLKKTVSVLHFTA
|   ||. .| .|....| ||  .  ..| .  | . |..|...|...|| ..||...     |. .|.  |..  |. ...     | ...|  .|.||
PLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.....ekavddd.flirtLkveaq.....kesrkvyqfhYta

WPDHGAPKNPDYALDIIRFCESYKT----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERT---TNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGV
||||| |....  |..|.  .....     ..||||||||||||..|| |  .|  .|..    .. ..|  .|. |  .||. .|  ..  .... |
WPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 941-1127 2.3e-30 100.2 In-house 102-279 (290) alignment
Range on Protein: 941-1127
Range on HMM: 102-279/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKlENFTDKKSFVMYNleykNDQWQDKKLKKtvsvLHFTA
. |.|    | .. | .|  .  |  .||    | ..|| || || .||| .||.    ..| .. . || . . .     |. ...|||.    |.  .
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk.daniikktlsvrd....kdsGkehklkh....lkiks

WPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|||.  ..     | ..|        | ||||||.|||||.|||. |.|. .  .  .|| .|  .||.| ..||   | . |.  .
wpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 940-1124 1.3e-29 98.3 In-house 96-276 (305) alignment
Range on Protein: 940-1124
Range on HMM: 96-276/305.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWqdKKLKKTVSVLHFT
 | |.|..  | .| .. |  . .|. ..| .. |   |. |...||. ||...|. || .|        . ... .|.  ...   .| ..||. ...|
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.......asdyieRklkisiede..dkesrtvlqyqlt

AWPDHGAPKNPDYALDIIRFC-ESYKT----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
 ||||| |. .   |..|.   ...|     ..||||||||||||. .|..  .. . .| . ..  ..  .|. | ..||. .| ..| 
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflh

subfamily_PTPRD_pd Subfamily PTPRD 941-1129 1.8e-28 94.5 In-house 99-279 (564) alignment
Range on Protein: 941-1129
Range on HMM: 99-279/564.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGeKMTFGRYTVTTKSiNTKLENFTDKKSFVmYNLEykndqwqdKKLKKTVSVLHFTA
|...|.|  |  . .... ..  | .. |..  |.. |. || | . |.|..||| .. ...|.... .. ..  . .        .. ...|   |||.
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtlee.eeeladyeirtfkl.kkkk........ssesreVrqFhFts

WPDHGAPKNPDYALDIIRFCESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
|||||.|...   ||.|| .....      ..|||||||||||| ..|.. ..  ..|.| .. ..|  .|. |   ||. .| ...   | .
WPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile

0041856 (Phosphotyrosine protein) phosphatases II 880-1128 1.3e-27 92.0 In-house 2-168 (182) alignment
Range on Protein: 880-1128
Range on HMM: 2-168/182.0
ISQRRHTLFLCEPKTMaklvgfPDPFINANVMKFGEIS--WIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGIVAQLAsviesddrkFA-
.. .|.. .|. . ..      .  .||||.. ..  .  .|..|||...                 |.....  . .......  |.            
ldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls.................tvadflrmlkelgittivnlt.........eel

--PyysekvgekmtfgrytvttksintklenftdkksfvmynleykndqwqdKKLKKTVSVLHFTAWPDHGAPKnPDYALDIIRFCESYKTSVLVHCSAG
  |                                                 ..|....  .... |||||.|  .| .||.|. ... .  ||||||||
ywp.................................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaG

VGRTGTLVAIKYGIQLctterTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
|||||||||. . ..|       .| ..|. ||..|.|.|.. .|. .|  .. 
vgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlall

subfamily_PTPN3_pd Subfamily PTPN3 875-1129 1.5e-27 91.2 In-house 37-273 (280) alignment
Range on Protein: 875-1129
Range on HMM: 37-273/280.0
NTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGeIswimaqgpmDGTEHLE-KISKvpPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDR
.  .|.|. |.   |   .|  ||.  .  .|||| ...  |         ..|.     |.     | ..| .. | .. . .. ..  |....|.   
rkpenlsknryrdilpydatrvklkesetdyinanyvnme.i.........pstglvnryiat..qGPlaktatdfWqmvweqksslivmlttlverGrv

KFAPYYSEkVGEKMTFGRYTVTTKSIntklenfTDKKSFVMYNLEYKNDQwqdKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK----TSVLV
|   |. |  ......|...|. ..          .||.|. .|  |. .   .| ....  | ..|||||| |....  |....  ....    . |.|
kChqyWPe.tedeleygefsvkceke.......detksyvlrelvlkdke...tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
|||||.|||| |....  ..|  ...  . | ||  .|. |   ||.|.|  ..  .| |
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 941-1124 1.5e-27 91.3 In-house 99-276 (290) alignment
Range on Protein: 941-1124
Range on HMM: 99-276/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMtFGRYTVTTksintklENFTDKKSFVMYNLEYKNDQWQdkKLKKTVSVLHFTA
| ..|| . | .|.| .| |.  | ..||..  |   |.... . |. .| ....         | .  ....  .|| ||.. .  . |..|  ...|.
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikl.......lneetlneyierklevknknsa..gakqsvtqyqitn

WPDHGAPKNPDYALDIIRFCES-----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
|...|  .||   | .|.  .       .||..||||..|||.....|.. .|. | ||   ......   | .. | ||..||. ...
wdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 878-1133 7.3e-27 89.1 In-house 42-273 (288) alignment
Range on Protein: 878-1133
Range on HMM: 42-273/288.0
ANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKfgeiswimaqgpmdGTEHLEKISkVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAP
|| .. |..   .   |  ||   || .|.|||.                ... ...      | ..|.|. | .. . ||  .  |. ..|   .| | 
anptrdryenlprcditrvklsddpdfyiaanvvs..............sakykrrli.caqaPlngtieelWkmllesdveyivmlcellekGkeksae

YYSEKVGEKMTFGRYTVTTKSINtklenfTDKKSFVMYNLEyKNDQWQDKKLkkTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGR
|.  |.|||. .||.   .|  .      .| .  |   |  .. .  ..|    | .||.  |.|.| |.|    | ..   .|..  ..||.||||||
yfPsklGekarigrlctvvkkkr......adidklvkvsll.riskegeekv..ivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGr

TGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMA
||||. |   ..    .    . |..   |. || |.|. .| .|.  |. . .. 
tgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll

subfamily_PTPRB_pd Subfamily PTPRB 941-1133 8e-27 89.0 In-house 102-287 (293) alignment
Range on Protein: 941-1133
Range on HMM: 102-287/293.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSintklenFTDKKSFVMYNLEYKNdqwqdKKLKKTVSVLHFTA
|  .|... | .. .  . |.  |  ..|    |   |. ..  | ...|  .|| ..        .... .|. .|. ..     .| ...|  .|||.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlva.......eeeledwvirelkiek.....ekeerkvrqyhfts

WPDHGAPKNPDYALDIIRFCESYK------TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMA
||||| |....  ||..|  ....      . ..||||||||||||..|..  .|  ..| . ....||. .|. |.  ||. .| ...  |. . .. 
WpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_PTPN13_pd Subfamily PTPN13 868-1123 1.4e-26 88.4 In-house 26-261 (273) alignment
Range on Protein: 868-1123
Range on HMM: 26-261/273.0
LDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDpFINANVMKFGEiswimaqgpmdGTEHLEKISKVPPKPKksTLEKHWAVIDQYDVGIVAQLASV
||   ......| .. |.   |   .|  || .    .|||. .|              | .. | |    | |.  | .  | .. . .. ..| ... 
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv...........gkdeyeyiacqGPlPe..tvkdfwqmvweqkaeviamvtle

IESDDRKFAPYYSEKVGEKMTfgrytvTTKSINTKLENFTDKKSFVMYNLEYKNDQWQDkklKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT--
 |..  |   |. |. ..|..       .  .. .|.. .....||. .|. |. . ..    . |. |.|..||||| |....  | ...   . .|  
kekgkvkchrywPesknkklk......vsnrlevellkvqkldgfvvralavkdsesge...srevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

-SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
  ..||||||.||.|||..|.  ..|   ..  ..  ||  .|. | | ||. .| .. 
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv

0043147 (Phosphotyrosine protein) phosphatases II 918-1124 1.7e-26 88.4 In-house 22-154 (172) alignment
Range on Protein: 918-1124
Range on HMM: 22-154/172.0
WIMAQGPmdgtehlekiskvppkpKKSTLEKHWAVIDQYDVGIVAQLASViesddrkfapyysekvgekmtfgrytvttksintklenftdkksfvmynl
.|. |||                   .||...|. . .......  | .                                                   
fiatqgp.................lrntladfwrmlkelgithivnltel..................................................

eykndQWQDKKLKKTVSVLHFTAWPDHGAPkNPDYALDIIRFCES-----YKTSVLVHCSAGVGRTGTLVAIKYGIqlctteRTTNLLSIVCPVRNCRFG
     .   ..|....  .... |||||.| .... |....|...      .  |||||||||||||||||. . .      .  .|. .|. ||..|.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpg

AVQSAQQLMYLI
|||. .|...| 
avqnpsqyrfly

0036282 (Phosphotyrosine protein) phosphatases II 919-1124 6.5e-26 86.5 In-house 20-163 (174) alignment
Range on Protein: 919-1124
Range on HMM: 20-163/174.0
IMAQGPMDgtehlekiskvppkpkkstlekHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEkvgekmtfgrytvttksintklenftdkksfvmynle
|  |||..                      .|. . .... .| .| . .| .  |.  |..|                                     
iagqgpla......................fwemlkelgittvvmlleekelglykcinywpe.....................................

ykndqwQDKKLKKTVSVLHFTAWPDHGAPKNPDyALDIIRFCESY-----KTSVLVHCSAGVGRTGTLVAIKYGIQLCTtERTTNLLSIVCPVRNCRFGA
        . |....  .... |||||.|  .   |....|.|..     .  |||||||||||||||||. . ...   |.. . |..|  .|..| |.
......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VQSAQQLMYLI
||. .|...| 
vqtpsQyrfly

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 941-1129 9.2e-26 85.5 In-house 98-277 (288) alignment
Range on Protein: 941-1129
Range on HMM: 98-277/288.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTkLENFTDKKSFVMynleykndqwqDKKLKKTVSVLHFTA
|  .|... | .. ....  .. |....| ...|   |. .. ...  .|  ||| .. .. ||.|. .|  .             || . ..  ....|
PladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveske.ledfvlrkllle...........kkkteleitqyqyla

WPDHGAPKNPDYALDIIRFCESYKTS----VLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
||||| |..    |...|  .  ...    ..|||||||||||| .|..  |.   .| . .....|. .|. |.  ||  .| ...  .. .
WpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 905-1126 2.3e-25 84.1 In-house 50-259 (270) alignment
Range on Protein: 905-1126
Range on HMM: 50-259/270.0
FINANVMKfgeiswimaqgpmdGTEHLEKISKVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFgrytvTTKSINTKLE
.|||| ..              | .. .|       |...||...| .| .  |  .. .. . |   .| . |......||...     ..  |..  .
YinAnyvr..............GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl.....edgkikvlal

NFTDKKSFVMYNLEYKnDQWQDkklKKTVsVLHFTAWPDHGAPKNPD---------YALDII-RFCESYKT--SVLVHCSAGVGRTGTLVAIKYGIQLCT
. . .. ... .|. . .. .    .. |   ....|||||.|...|         . |  . |.... .    .||||||||||||||.|. ....|  
seekeegyiltrlrle.ekgee...rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe

TERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
...  ..|.|.  .|. |   ||  .|  .|   
etkkvdvlaiieelRkdRmalvqhpeqyeflyka

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 940-1124 4.5e-25 83.3 In-house 89-270 (307) alignment
Range on Protein: 940-1124
Range on HMM: 89-270/307.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVmyNLEYKNDQWQDKklKKTVSVLHFT
 |...|  . ||.. | .|  |  |. |||    |   |.  . |.|..||  . |    |   ....  . ..  |.   . .| .|   .|.. | ..
gplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli..nvttlkvdwaqk..srtiqhlqwe

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGI-QLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
 |||.|.|.    |....   .  .  |.|||||||||.||.||| .   .. . .   ..  .|  .|. |  |.|.  | .|| 
nwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 940-1128 6.2e-25 83.0 In-house 106-287 (298) alignment
Range on Protein: 940-1128
Range on HMM: 106-287/298.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGRYTVttksintKLENFTDKKSFVMYNLEYKNDQWQdkkLKKTVSVLHFT
.| ..|.|  | .. ..|.| .  | .. |.|  |.  |. ..  .| |.|. ||       .| .  ..  ... .|. .. . .    ...|  ||||
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv.......sllskeefadlivrklkvskkkee...kerevrqlhft

AWPDHGAPKNPDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
 |||.|.|.|    ||..|  . ..     ..|.|.|||||||.|| .||.  ..   .|..  .. .|  .|. | ||||. .| ...   . 
sWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl

PTPc_DSPc_SM00012 1032-1127 7.7e-25 82.5 In-house 1-103 (105) alignment
Range on Protein: 1032-1127
Range on HMM: 1-103/105.0
TVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT------SVLVHCSAGVGRTGTLVAIKYGIQLCTTE-RTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
||...|.|.|||||.|...|  |...| ... |.      .|.||||||||||||.||. . .| ...| .. ... ||. .|. | |.||. .| ..|.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

VCI
 ..
ral

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 940-1128 8.1e-25 81.9 In-house 93-273 (515) alignment
Range on Protein: 940-1128
Range on HMM: 93-273/515.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFtdKKSFVMYnleyKNDQwqdkklKKTVSVLHFT
 |.|....  | .. |..|  .| ..   |.|  | . |. .| |. . || . | . |...  .    |. . .     |.|.       .||   |||
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggi..krkltvl....kgdd......srtvtqfhft

AWPDHGAPKNPDYALDIIRFCES----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
 |||.|.||.    | .|.   .    |. ....|||||||||| ...|.  .    | |. ... .|  .|. |   ||  .|  ..   . 
eWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 941-1124 9.1e-25 82.3 In-house 81-261 (274) alignment
Range on Protein: 941-1124
Range on HMM: 81-261/274.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMT--FGRYTVTTKSINTKlENFTDKKSFVMYNLEYKNdqwqdkklkktVSVLHF
|  .|..  | .| | .| ..  |. . |.. .| | |. .. . ...  .|   .....|... .... .|  . |  . ..           |    .
PlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiver.ndysvrklvlkylerers...........vkhywy

TAWPDHGAPKNPDYALDIIRFCESYK-------TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
|.|||| .|....  ||...  |. .       ..|.||||||.||||  .||. ...    | . ..|.||| .|  | | ||...|  .. 
tdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelih

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 941-1126 2e-24 81.1 In-house 94-273 (287) alignment
Range on Protein: 941-1126
Range on HMM: 94-273/287.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGekMTFGRYTVTtksintkLENFTDKKSFVMYNLEYKNDQWQDKklKKTVSVLHFTA
|  .|. . | .||.  | ..  |.   |.|...   |..|.    ...| |...       | | . ...... .|| ||.. ...  |..|   ..|.
PmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeynie.......llneevnagyierklevknknkagd..kqqvkqyqitn

WPDHGAPKNPDYALDIIRF--C---ESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
|...|  ..|   | .|         . .||..||||..|||.....|.  .|. | || . ......   |  . |.|| ..| ....  
WdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindi

subfamily_PTPRA_pd Subfamily PTPRA 941-1123 2.2e-24 80.9 In-house 109-287 (330) alignment
Range on Protein: 941-1123
Range on HMM: 109-287/330.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGeKMTFGRYTVTTKSiNTKLENFTDKKSFVMyNLeykNDQwQDKKLKKTVSVLHFTA
||. |.|  | .| ...   .  |. . | .. | | |. .. |  .|.|  .|. .  .| |...| .|  |  .|   .|. ...| .. |. .|||.
PkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyGnirveved.etvlvdytvrkflvq.ql...pda.trekksrlvrqfhfts

WPDHGAPKNPDYALDIIRFCES----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
||| | | .|   |....  ..    .  .. ||||||||||||.....  ..   .||  ..  .|  .|. |   ||. .|  ..
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

0049260 (Phosphotyrosine protein) phosphatases II 941-1124 2.6e-24 81.1 In-house 17-143 (152) alignment
Range on Protein: 941-1124
Range on HMM: 17-143/152.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYsekvgekmtfgrytvttksintklenftdkksfvmynleykndqwqdkklkktvsVLHFTA
|   ||...|  . .......  | .  | .  |.. |.                                                         ... 
pgpntladfwrmlkelgittivmltellelgklkceqyi.......................................................qylhlp

WPDHGAPKNPDYALDIIRF----CESYKTSVLVHCSAGVGRTGTLVAIKYGIqlctteRTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
|||||.|..... |....|    ... .  |||||||||||||||||. . .      .  .|. .|  ||..| |||.. .||..| 
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_PTPRG_pd Subfamily PTPRG 940-1152 3.1e-24 80.1 In-house 98-311 (563) alignment
Range on Protein: 940-1152
Range on HMM: 98-311/563.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTKleNFTDKKSFVMYNLEYKNDQWqdKKLKKTVSVLHFT
.| |.|..  | .| .  | |.  .. . |.  ||   |. .   | .|.|  .|| .. ...      ....|. ||. |. .   .. .|.|   |.|
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevl..alytvrtlviknlklkkkkq..cdteklvrqyhyt

AWPDHGAPKNPDYALDIIRFCESYKTS----VLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKE
 |||||.|. . . |  ..  .  . .    ..||||||||||||.....  ..   .| . |.. ..  .|  |   ||.  | ..|   . . ...||
kWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

GVLYWRSFDA---ITYYHEQ
  |     ..   .| | ||
tellaeqveelknctpyleq

0046846 (Phosphotyrosine protein) phosphatases II 941-1127 4.2e-24 80.7 In-house 31-169 (176) alignment
Range on Protein: 941-1127
Range on HMM: 31-169/176.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMtfgrytvttksintklenftdkksfvmynleykndqwqdkklkktvsVLHFTA
|  .||.. .. . ......|  | . .| .  |.. |..|  ....                                                 ... 
plprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................................qylhlp

WPDHGAPKNpDYALDIIRFCESYK---TSVLVHCSAGVGRTGTLVAIKygiqLCTTERTTNLLSIVCPVRNCRF-GAVQSAQQLMYLIVCI
|||||.|   .. |....|....      ||||||||.||||||||.     |. .|.  ... ... ||..|. ||||. .|. .|  ..
wpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefe

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 925-1137 5.2e-24 79.7 In-house 69-275 (285) alignment
Range on Protein: 925-1137
Range on HMM: 69-275/285.0
MDGTEHLEKISKVPPKPkkSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMYNLEyknDQW
| | ..   |.   | |   ||   | .| |  .  |  |....|    | | || ||.|| . ||.| .|    . .    |  ... . | |   |  
mpgkdqstyittqgplp..etlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvinte...das

QDKKLKKTVSVlhfTAWPDHGAPKNPDYALDIIRFCE---SYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLM
 .    . | |     |||. ||..    ... .. .     .. . |||||||||| |.| | |       .   ..| ||  .|  || ||||  |..
seplymnhvqv...pwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqfl

YLIVCITKGVMaKEGV
.| | . . ..  |||
flyvvlmeyfi.gegv

0051429 (Phosphotyrosine protein) phosphatases II 944-1129 7.1e-24 80.3 In-house 33-223 (272) alignment
Range on Protein: 944-1129
Range on HMM: 33-223/272.0
STLEKHWAViDQYDVGIVAQLASVIESDDRKFAPYYS----------EKVGEKMTFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWQDKKlkKTV
 | .  |.   ....  .  | |. | .  |. .|            . . . ...|...||. |. ..|        .....|....    ..    .|
ltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld.......yilrellltlllsagea..rev

SVLHFTAWPDHGAPKNPdyALDIIRFCESyKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTN--------LLSIVCPVRNCRFGAVQSAQQLMYLIV
 .||.|.|||||.|...   |...... . .  ||||||||..||||.||. . ..  . |   .        |. .|  .| .| ||||. .|...|  
mhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

CITK
.. .
alle

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 939-1125 1.9e-23 77.6 In-house 96-275 (301) alignment
Range on Protein: 939-1125
Range on HMM: 96-275/301.0
PKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMynleyKnDQwQDKKLKKTVSVLHF
  | |.| |  ||.. ||||  .. |.  .|   .| . |.. |..||.  ||.....|. .. |.. . |... .     . |   .|   .||    .
qgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlev.....e.ds.tgkfatrtvthyqy

TAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
. |.|.| ||      |.. .    .  ..||||||.||. .... .|  .   ...| .|   .  .|. |. .||  .|| .. .
sewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 941-1129 2.2e-23 77.7 In-house 92-274 (281) alignment
Range on Protein: 941-1129
Range on HMM: 92-274/281.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVgEKMTFGRYTVTTKSINtklenftDKKSFVMYNLEYKNDQWQdkklKKTVSVLHFTA
|  ..|.. | .. ...| ... ..  ||..  |   |. ..  .....| .||.... .       .|....  ... .... .    ...|. |..||
PvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.selkygdvtvkstaee.......ekatyierkfkleresge....treveqlayta

WPDHGAPKNPDYALD----IIRFCESYK-TSVLVHCSAGVGRTGTLVAIKYGIQLCTTE-RTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
|||||.|...   |.    . .. |. . .....||||||||||| .|.   .. ...| .....  .|  .|. |   ||.  |  ..   . .
WPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 940-1129 2.7e-23 77.5 In-house 59-240 (250) alignment
Range on Protein: 940-1129
Range on HMM: 59-240/250.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRkFAPYYSEKVgeKMTFGRYTVTTKSIntklENFTDkksFVMYNLEYKNDQwqdKKLKKTVSVLHFT
.| ..|.|. | .. ....| .  |... ||.   .  |.  ..    ..|  ||. .|     |.|.|   ... .|   . .   |. ...|  |||.
gPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyGdvtvsllsk....eefad...ytkrklklskak...kaderivrqlhfv

AWPDHGAPKNPDYALDIIRFCESYKTS-----VLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
.||| | |..   .|....  .. .       |.|.|||||||.|. .||.  ..   .|.. ..  ..  .|. | .||.| .| ...   | |
vWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 940-1130 2.7e-23 77.3 In-house 94-276 (315) alignment
Range on Protein: 940-1130
Range on HMM: 94-276/315.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTdKKSfVMYNleykNDQwqdkklKKTVSVLHFT
 |.|....  | .. |..|  .. ..   |.|  | . |. .. .. . || . |.. |...  .  . .|  |. .     ..      ..||.  .||
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgva.rkl.vtrk....see......srtvtqfqft

AWPDHGAPKNPDYALDIIRFCE----SYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG
 |||.|..|.    | .|.       ... |.|||||||||||| ...|.  ..    .|. ... .|  .|. |   ||. ..  ..   . . 
ewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 941-1131 4.1e-23 76.9 In-house 97-280 (318) alignment
Range on Protein: 941-1131
Range on HMM: 97-280/318.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGRYTVTtksintkLENFTDKKSFVMYNLEYKNdqwQDKKLKKTVSVLHFTA
|   |.|  | .. . .  ..  |. . |.  .| . |. .|  . ...|. .|.       |.. .. ...|. ... ..   .... ...|   |.|.
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvve.......lkeevelsdyvlrefkvtr...teeeesrqvrqyhyts

WPDHGAPKNPDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGV
|||.| |...   ||..|  ....     . ..|||||||||||. .|..  ..    | . ... .|  .|. |   ||  .|  ..   ... .
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal

subfamily_PTPN6_pd Subfamily PTPN6 943-1129 4.7e-23 76.6 In-house 108-295 (306) alignment
Range on Protein: 943-1129
Range on HMM: 108-295/306.0
KSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMtFGRYTVTTKSINtklenftDKKSFVMYNLEYKNDqwQDKKLKKTVSVLHFTAWP
..|..  | .. | .  ..  .   .|    | |.|. ..  ... .|...||. | .       ....... .|  ..   ..|| ...|  .||..||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.......sladYilRelsvskk..kkkkeerevfqyhfksWP

DHGAPKNPDYALDIIR----FCESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTT---ERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
||| ||.|.  || ..      |. .     ...||||||.|||||.. |   ..| ..   .  ... ..|  ||. | | || .||  ..   |.|
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk

subfamily_Ptp69D_pd Subfamily Ptp69D 941-1125 5.1e-23 76.7 In-house 99-280 (307) alignment
Range on Protein: 941-1125
Range on HMM: 99-280/307.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGrytvttkSINTKLENFTDKKSFVMYNLEYKNDQ--WQDKKLKKTVSVLHF
|  .|..  | .| . .| ..  |. . | ...| | |...   ... .|       .|. || ..  .. ... .|.. . .    . . .. |   |.
PveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.......dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhy

TAWPDHGAPKNPDYALDIIRFC-ESY---KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
|.|.|  .|. .   |..|.   | |   .. ..|||||||||.|..||..  .| . .| . ..  .|. .|. |   ||| .| ..|  
tgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyr

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 941-1125 5.9e-23 76.3 In-house 100-273 (315) alignment
Range on Protein: 941-1125
Range on HMM: 100-273/315.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgeKMTFGRYTVTTKSINTKlENFTDKkSFvmynleyknDQWQDKKLkKTVSVLHFTA
|. ....  | .. ..|.| .  |....| . ||   |. .|   |...|..||| || . . ...| . ..             .... ..|  ||.|.
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevn.teytvr.tl.........svvfgdni.revvqlhyts

WPDHGAPKNPDYALDIIRFCESYKT----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
||| | ||     ...||    ..|    ...||||||||||||.....  ..   .|.  ..  ..  ||. | ..||.|.|  ..  
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyd

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 940-1135 9.4e-23 75.8 In-house 99-288 (297) alignment
Range on Protein: 940-1135
Range on HMM: 99-288/297.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrKFAPYYSEKVgeKMTFGRYTVTTKSINtklenftDKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFT
.|.|.|..  ||.. ...| ... |.   |.|. | | |.|.|    .|||  .|...|..       ... |.  .|| ...   . | .. |   .|.
mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvs.......ereGfikrelevtkg...kakarrvvkqyqfv

AWPDHGAPK--NPDYALDIIRFC-ESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
 |||.  ..  .  . |..|    ....    . .||||.||||||| |..|.  .     | . ... .|  .|. |   ||  .|  .. | . . ..
eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

AKE
...
sed

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 901-1137 1.8e-22 74.8 In-house 44-257 (290) alignment
Range on Protein: 901-1137
Range on HMM: 44-257/290.0
FPDPFINANVMKF-GEISWIMAQGPMDGTehlekiskvpPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDR--K--FAPYYSEKVGEKMTFGRYTVT
| | .| || ...   .  |. | |   .           . ..||.||.| .. |  |  | .|  . | .    .   | |. |.|||...|.  || 
fnddyiHAnrvtcpnglrliltqsPqeki..........tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvk

TKSINTKlENFTDKKSFVMYnleykndqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCT-TE
 ||  .. ...  ..  | .          |.. . ||    .  | .  .....  .|..|.. . .|| |.|||  |. |  .| ||. | |.   |.
Ckskeke.ddvetRelvvkf..........ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaets

RTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITkgvmakegV
  ..| ...  .|. |  |..||..| . .  |         .
gsvkledvlkalrkqralaitsalelafvdagiv........l

subfamily_PTPN23_pd Subfamily PTPN23 941-1134 1.9e-22 74.4 In-house 91-286 (288) alignment
Range on Protein: 941-1134
Range on HMM: 91-286/288.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYkndQWQDKKLKKTVSVLHFTA
|..|||   | .. .  . ..  | |  | .. | . |. |. || ..|| ..|| || ..        . .| ..|.    . .|.. .|.|| |..|.
PlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.......tethvervlkl...etldadavksvshlqlts

WPDHGAPKNPDYALDIIRFCES--------YKTSVLVHCSAGVGRTGTLVAIKYGIQLC-TTERTTNLLSIVCPVRNCRFGAVQSAQQLMY---LIVCIT
||..|.|. |.  |...   ||         || ..|||||||||||..  .   ..   . .  .... .|  .|. |   ||  .||      ... .
WpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

KGVMAK
. |. |
rrvldk

0048076 (Phosphotyrosine protein) phosphatases II 983-1127 1.9e-21 71.7 In-house 7-139 (145) alignment
Range on Protein: 983-1127
Range on HMM: 7-139/145.0
VGEKMTFGRYTVTTKsintkLENFTDKKSFVMYNLeykndQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY---KTSVLVHCSAGVGRTG
. ... .| .... .     ||.. | .    .||         . |....  .... |||||.|  ... |....|.|..   .  |||||||||||||
ilpglylgslptald.....lellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtg

TLVAIKYGIQlctteRTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
||||.   ..     .  .| ...  ||..|.|||.. .|| .|. ..
tlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe

subfamily_PTPN1_pd Subfamily PTPN1 941-1132 2.1e-21 70.9 In-house 79-272 (290) alignment
Range on Protein: 941-1132
Range on HMM: 79-272/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVG-EKMTFGRYTVTTKSINTKlenftDKKSFVMYNLEYKNDQWQDkklKKTVSVLHFT
|  .| .  | .. . .   |  |  |.| .  | | |. ..   .....   ... | |...     .|. ...  || .| . |.    ....  |.|
PlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklisee.....rksyytvrllelenlktqe...treilhfhyt

AWPDHGAPKNPDYALDIIRFCE---S---YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTER---TTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG
.||| | |. | . |. .  .    |    .  ...|||||.||.||.. .   . |   .    . ..   .. .|. |.| .| |.|| .  . | .|
twpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

VM
. 
ak

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 940-1129 2.2e-21 71.3 In-house 98-281 (319) alignment
Range on Protein: 940-1129
Range on HMM: 98-281/319.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGRYTVTTKSiNTKLENFTDKKsfvmYNLEYKNDQWQDkklkKTVSVLHFT
 |.. |.|  | .. .... ||  |. . |  . |.  |..|.  . ...||..|| .. . .||..  .|     .|. |... .     ..|.  ..|
aPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtlee.eeeledyiirk....lklnkkssevet....Revkhfqyt

AWPDHGAPKNPDYALDIIRFCESYKT-----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
.||||. |..    ||...  .  .       . |||||||||||| ....  ..    | . .. |.|  .|  |   ||  .|  ..   . .
eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 941-1124 1.1e-20 68.5 In-house 104-282 (305) alignment
Range on Protein: 941-1124
Range on HMM: 104-282/305.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMYNLEYKNDQwqdkklKKTVSVLHFTA
|   |... | .. |  |  .  |.  .|    | | |.    |||...    |  .   .|  .   .    . || |  ||      | .|  |..| 
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdq......kmsvrhlqwte

WPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTT-ERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
||| | |     .|...      |  ..||||||.|||||.|||.| ..  .   .   .  .|  .|. |  ..|.  | ... 
wpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfih

0048179 (Phosphotyrosine protein) phosphatases II 1027-1124 1.2e-20 69.2 In-house 43-138 (144) alignment
Range on Protein: 1027-1124
Range on HMM: 43-138/144.0
KKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY---KTSVLVHCSAGVGRTGTLVAIKygiqLCTTERtTNLLSIVCPVRNCRFGAVQSAQQLMYL
  |....  .... |||||.|  ... |....|.|..   .  |||||||||||||||||.     |. ...  .| ...  ||..|.|||.. .||..|
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfL

I
.
l

0044763 (Phosphotyrosine protein) phosphatases II 947-1126 9.5e-20 66.4 In-house 38-166 (178) alignment
Range on Protein: 947-1126
Range on HMM: 38-166/178.0
EKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGekmtfgrytvttksintklenftdkksfvmynleykndqwqdkklkktvSVLHFTAWPDHGA
..... . ..... .  |.. .|    |  ||. |. |                                                    ... .||||.
addlellkelgithivnlteelelgflkcdpywpeeag.................................................iqylhipipDhgv

PKNPDYALDIIRFCE----SYKTSVLVHCSAGVGRTGTLVAIKYGIQLctterTTNLLSIVCPVRNCRFgAVQSAQQLMYLIVC
|  ... |....|.|    . .  |||||||||||.|||||. . ..|       .| ...  ||..|. .|..  || .|. .
pdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef

0049772 (Phosphotyrosine protein) phosphatases II 905-1123 1.1e-19 66.8 In-house 74-272 (314) alignment
Range on Protein: 905-1123
Range on HMM: 74-272/314.0
FINANVMKFGeISWIMAQGpmdgtehlekiskvppkPKKSTLEKH----------WAVI--DQYDVGIVAQ---------------------LASVIESD
.|||. ..    ..| .||                 |.. |..            | ..  ....| ..                       | .. .  
yinasyvdgf.lkfIatqg.................pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng

drkfapyysekvgeK---------MTfgrytvttksintklenftdkksfvmynleykNDQWQDKKLKKTVSVLHFTAWPDHGAPkNPDYALDIIRFCES
                        .                                 . .. ........  .. . .||..||  ... .....|.|.
..............neptaadlellk................................eelydpelferlgikylripvpDgsap.lledfdeflefiee

--YKTSVLVHCSAGVGRTGTLVAIKYGIQLCtterTTNLLSIVCPVRNCRF-----GAVQSAQQLMYL
   .. |||||.||.|||||.|.. | . |.      .|  ..  ||..|.     |.... .|. . 
adkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi

0051082 (Phosphotyrosine protein) phosphatases II 941-1126 1.2e-19 65.9 In-house 23-148 (151) alignment
Range on Protein: 941-1126
Range on HMM: 23-148/151.0
PkkstleKHWAVIDQYDVGIVAQLASVIESDdrkFAPYYSEKVGekmtfgrytvttksintklenftdkksfvmynleykndqwqdkklkKTVSVLHFTA
.       ... . ....  .  | |  | .   . | | .. |                                               .|  .... 
a......dflellkelgiktivnlrseeerg...ycpeylpelg..............................................ievlhipild

WPDHGAPKNPDYALDIIRFCESY-KTSVLVHCSAGVGRTGTLVAIKYGIqLCttertTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
|||.| | ..| .|........  .  ||||||||.||||||||.   . |       .| ...  .| .|.|.||. || .... .
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfqlfa

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 940-1137 6.8e-19 63.3 In-house 111-298 (319) alignment
Range on Protein: 940-1137
Range on HMM: 111-298/319.0
KPKKSTLEKHWAVIDQYDVGIVAQLAsviesdDRKFAPYYSEKVGEKmtFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQwqDKKLKKTVSVLHFT
 |.. ||.  | .| .|..  .  |.        | . |.  |. .|   .|. |  .|..   |       .|. ..|  .|    .| .. .   || 
GPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveetae.......yvvrdielsedg..kekdirkitqfhfl

AWPDHGAPKNPDYALDIIRF------CESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG-VM
 |||.| |. |   . ...        |  .....|||||||||||. ....  ..    |.  ..  .|  .|. |   ||.  | ... . . .  ..
GwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

AKEGV
..  |
ghsdv

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 941-1153 1.1e-18 62.7 In-house 76-275 (284) alignment
Range on Protein: 941-1153
Range on HMM: 76-275/284.0
PKKSTLEKHWAVIDQYDVGIVAQLAsviesdDRKFAPYYSEKVGEKmtFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWqdKKLKKTVSVLHFTA
|.. ||.  | .| .|..  .  |.      . | . |.  |. .|   .|. |  .|..   |       .|. ..|  .|    .| ....   ||  
PldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveesee.......yvvrdielsedgk..ekdirkirqfhflg

WPDHGAPKNPDYALDIIRF------CESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAK
|||.| |. |   . ...        |  .....|||||||||||. ....  ..    |.  ..  .|  .|. |   ||.  | ... . . .  .  
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

EGVLYWRSFDAitYYHEQI
   .    | |  |..|. 
hsdvalpdfpa..yleels

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 939-1128 4.2e-18 60.1 In-house 91-290 (301) alignment
Range on Protein: 939-1128
Range on HMM: 91-290/301.0
PKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSiNTKLENFTDKKSFVMYNLEYK----NDQW--QDKKLKKT
  | |.||   | .| |. .  .  ..   |.   |   |...   |. .||  ||| .. .. . .|. ..  |. .   .    . ..  . .|  ..
qgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvn.eqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswd

VSVLHFTAWPDHGAPKNPDYALDI-----IRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|  |. | ||..|  ..|   | .     .|     .  |.||||..|.|.|. ...  |.  |  |   ..  ..  ||  . |||.  .| . .   |
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

T
.
d

subfamily_PTPRK_pd Subfamily PTPRK 939-1144 4.4e-18 60.2 In-house 92-290 (314) alignment
Range on Protein: 939-1144
Range on HMM: 92-290/314.0
PKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgeKMTFGRYTVTTKSINTKLENFtdKKSFVMYNleykndQWQDKKLKKTVSVLHF
 .|...|..  | .. ...   .  |. ..|    |   |. |.    ...|   |.  . ... |    .. | ...        . .. ...|  ..|
qgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed...tevygdikvelvetellaelv..vrifrvek......largqeeirevrqfqf

TAWPDHGAPKNPDYALDIIRFCESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAK
..||||. |..    |...|  .. .      ..|||||| ||||| .||.  ...  .|.. ..  .|  .|. .   |.  .| ...   |   ... 
lgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcg

EGVLYWRSFD
|  .    | 
etaipvsefk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 938-1128 6e-18 59.5 In-house 96-276 (439) alignment
Range on Protein: 938-1128
Range on HMM: 96-276/439.0
PPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrkfapYYSEkvGEKMTFGRYTVTTKsINTKLENFTDkKSFVMYNleyKNDQwqDKKlKKTVSVLH
 . ||| | .. | .. .  .  . .|. ..||       |.     ... .|  .| .   | .| |..  . | ..|   . |.   .| ..||  .|
tqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps..daevcygdiavrvd.rnielpnyvi.rgfkvfn...erdt..tek.ertvlqfh

FTAWPDHGAPKNPDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
..||||.  | .  . || .|  .| .       |.||||||||||||..|.   ..   .|   ..  ||  .|. |   ||.  | ...  .. 
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 941-1144 1.3e-17 58.9 In-house 99-301 (325) alignment
Range on Protein: 941-1144
Range on HMM: 99-301/325.0
PKKSTLEKHWAVIDQYDVGIVAqLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSIntklENFTDkksFVMYNLEYKNDQwqdKKLKKTVSVLHFTA
|. .|..  | .. ..   .|  .  ... .. . | |. ...|.  |||   |  ..|    |...|   .|.  |. |. .   |   ..|  ... .
PltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrti....eeisd...yvhrvldvkqvk...kGetrsvkqfqlqs

WPDHGAPKNPDYALDIIRFCE----SY------KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG
|.| | .| |   . |..  .             | .||||||||||||.....   ..   .|   ...  |  .|. |   |... | . .  .... 
wddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea

VMAKEGVLYWRSFD
.|. .  .   ||.
ymsgntdvpvssfe

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 941-1151 2.3e-17 57.7 In-house 90-294 (312) alignment
Range on Protein: 941-1151
Range on HMM: 90-294/312.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEkMTFGRYTVTTKSInTKLEN---FTDKKSFVMYNLEYKNdQWQDKKLKKtvsvLH
| ..|  . | .        .  |....|    | | | |. ||  . .  . | |..  |..|      || .  . ..  |    |. ||..      
plentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdledhrvyteyc.teieiggkskdkithrvlkvvvka.tgqesklnh....yq

FTAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEgv
...||||| |   | || ..      |  |. ||||||||||||. |.  |      |  |.  .   .|. |  .|.   | .| . |. . ...|   
waswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg..

LYWRSFDAITYYHE
|| |. .  | ..|
lykrneqewtkfke

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 942-1124 4.9e-17 56.6 In-house 97-280 (305) alignment
Range on Protein: 942-1124
Range on HMM: 97-280/305.0
KKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFG--RYTVTTKSINTKLENFTDKKSFVMYNLEYKNDQWQDKKLKktVSVLHFT
 . |    | .  |  |  .  |  ..|   .| . |.. | .....|      .. |   ..  .|... . .. . .   .    |..|  |.  |. 
lektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekark..vthyhwi

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGI-QLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
 ||| | |      |...  . . |  . ||||||.||||..| ..| . || . .   .   |.  .|. |  ..|. .| ... 
dwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh

subfamily_PTPN14_pd Subfamily PTPN14 940-1124 1e-16 55.8 In-house 100-289 (300) alignment
Range on Protein: 940-1124
Range on HMM: 100-289/300.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEK--VGEKMTFGRYTVTTKSINTKLENFTDKksFVMYNLEykndqwqdKKLKKTVSVLH
 | . |....| .. . .| ....|.. .|.   |   |. ..    ....||.. ||||  ..     | .  . .. |          | ..||  | 
gPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittg..lklkhlp........skeertvwhlq

FTAWPDHGAPKNPDYALDIIRFCESYK-------------TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
.| ||||| |....  |. ..  .| .               ||||||||||||| |.     |.   .... .. ...  .|. |   ||.  |  .. 
ytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvY





subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 928-1129 1.8e-16 55.0 In-house 22-219 (255) alignment
Range on Protein: 928-1129
Range on HMM: 22-219/255.0
TEHLEKISKVPPKPKKS-TLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSintklenftDKKSFVMYNLEYKNdQWQD
|||..   ..  |   | |..| . .| | .   |. |.   | .  |   |.  .  ||. .   .|||                |.  ||    .  .
tehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.........ssadvvlrtleits.tlge

KKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYkTSVLVHCSAGVGRTGTLVAIKYGIQ-----LCTTErTT--NLLSIVCPVRNCRFGAVQSAQQ
||  .||   ... |... ||...   | |..       ||.||||.|.||. ..| . .  |     | ||| |.  . ||..  .|. | .|..   |
kkkthtvkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldtte.tveldylslleelrskrkraihtPlq

LMYLIVCITK
| . |. . .
lafsilmvld

subfamily_PTPRN_pd Subfamily PTPRN 940-1132 1.8e-16 54.7 In-house 107-293 (297) alignment
Range on Protein: 940-1132
Range on HMM: 107-293/297.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKmTFGRYTVTTKSINTKLENFTdKKSFVMYNLEYKNdqwqdkklKKTVSVLHFT
 |  ||. . | .. .  | .. .|... |.. .. . |. .. |.. ... | |   |     ...   .|| . ||. ..         .||. .|| 
gplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde.Gse.vyhiyevhlvsehiwcddyl.vrsfylknlqtse........trtvtqfhfl

AWPDHGAPKNPDYALDIIRFC-ESYK---TSVLVHCSAGVGRTGTLVAIKYGI-QLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
.||..|.| ..   |.  |    ||.   ....||||.|.||||. ..|   . .|    .  .. . .  .|. | | |.. .|. . . .... | 
swpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 940-1125 2.4e-16 54.2 In-house 88-264 (281) alignment
Range on Protein: 940-1125
Range on HMM: 88-264/281.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTtksintkLENFTDKKSFVMYNLEYKNDQwqDkklKKTVSVLHFT
 ||| |    | .| | .   .  |. ..|..  | | |.  .    . | ...|.        |. | .||.|   |.   .   .    . ..   . 
gpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvs.......yedstvnkslvttrlnlsyeg..e...trlithwlwk

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTT-NLLSIVCPVRN-CRFGAVQSAQQLMYLI-V
 |||   |.  .  | |.|   .  |  ..||||||||.|||.|..  .|   .  |  ..  ||  .|   |  .||. || | .  |
ewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkv

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 940-1133 3.6e-16 53.6 In-house 95-238 (392) alignment
Range on Protein: 940-1133
Range on HMM: 95-238/392.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDdrkfapyysekvgekmtfgrytvttksintklenftdkksfvmynleykndqwqDKKLKKTVSVLHFT
 |. ..|.  | .. | .|  .| .. . | |                                                        . ..||.  |||
gpnaaslddfwrmvfqenvttiamvtklkegd......................................................kgddartvaqfhft

AWPDHGAPKNPDYALDIIRFCE----SYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMA
 |||.. ||     | .|.  .    .|   ...|||||||||| ...|   .  . . |  ... .|  .|. |   ||. .|  ..  .. . .. 
ewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw

subfamily_CG7180_pd Subfamily CG7180 940-1133 4.3e-15 50.1 In-house 92-292 (296) alignment
Range on Protein: 940-1133
Range on HMM: 92-292/296.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrKFAPYYSEKVgeKMTFGRYTVTTKSInTKLENFTDKKSFVMYN-LEYKNDQWQDKKLKKTVSVLHF
 |||.|....| .. . ..  |  |. . .    ..  |. .|   |  .|   | . .   .. |.. ..  .. . .   . . | |  ...| ....
apkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveivee.kqyanlkirtfkltkkivalteqekqvkaetRivklfql

TAWPD-HGAPKNPDYALDIIRFCESYKTSV---------LVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
| |.  .  |      ....|  ....  |         .|..| |..|.|  .||   ..|   |   ..   |  .|. | . |.. .. .|.   . 
teWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

KGVMA
. |..
eavlc

subfamily_PTPN9_pd Subfamily PTPN9 941-1124 1.3e-14 48.9 In-house 93-283 (297) alignment
Range on Protein: 941-1124
Range on HMM: 93-283/297.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTksINTKLENFTDKKSFVMYNLEykNDQwqdkklKKTVSVLHFTA
| | | . .| .. . .| ..   . |.|   .| . |. .. .. . || ..|..  .... |.   .......| .  ...      ...|.   |..
plkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsn..veveeeedykvrvleiknvk..tee......srkvthfqfls

WPDHGAPKNPDYALDIIRFCESYKT-----------------SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
|||.| |..    ||...   ....                  ..||||||.|||||.... . ..   .. | ..   |  .|. |  ..|  .| .. 
WPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefc

I
 
y

subfamily_hpo-7_pd Subfamily hpo-7 940-1132 3.5e-14 47.3 In-house 37-228 (263) alignment
Range on Protein: 940-1132
Range on HMM: 37-228/263.0
KPKKS----TLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTklenftdkkSFVMYNLEYKNDqWQDKKLKKTVSV
|   |    |..| .  | |     |. |.   | .  |   |.  .  ||. .   .|.|  .             ..  ||  .   ..||  .||  
knlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.........dvllktlellst.lgeKkkthtvkh

LHFTAWPDHGAPKNPDYALDIIRFCESYkTSVLVHCSAGVGRTGTLVAIKYGIQ----LCTTERTT--NLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
  .. |... .|...   | |..       |. ||||.|.||.   . .    |       |  |.  . ||..  .|. | .|..   || . |. . .
ysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

GVM
 |.
fvl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 940-1123 5.1e-14 46.8 In-house 82-258 (283) alignment
Range on Protein: 940-1123
Range on HMM: 82-258/283.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEkmTFGRYTVTTKSINTKlENFTDKKSFVMYNleykndqwqdKK-----LkktVS
 | . |    | .. . ..  .  |. . |  . | . |. ..  |   .| .||| .   |. . |. |.  . .|                 |   ..
sPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse..dyGeftvtlrketts.nsfiikelllrvn..........ssakstll...la

VLHFTAWPDH--GAPKNPD--YALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
   .  | .   .|. |    . . |    || |. ..||||.|.|||....|.   ..   ||   .. ..|  .|. | .|||. .| . .
hyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 940-1124 5.7e-14 46.9 In-house 52-232 (237) alignment
Range on Protein: 940-1124
Range on HMM: 52-232/237.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEkVGEKMTFGRYTVTTKsintKLENFTDKKSFVMyNLeykNDQWQDKKLKkTVSVLHFT
 | .|. .  | .. |    ..  |. .||... |   |. .   .  ..| .||. |    | |.|.|     .  |     ... |...  .   .||
gplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaaygvltvslk....kkeefsdytvrsl.ll...skrltlkevr.lihqyqft

AWPDHGAPKNPDYAL----DIIRFCES--YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
.|||.| |..    |    .||   .     .  ..|||||||||| .. |   .. .  ..  ..   |  . . |   .|. .| ... 
swpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 941-1127 1.1e-12 42.4 In-house 88-273 (287) alignment
Range on Protein: 941-1127
Range on HMM: 88-273/287.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTKLENFTdKKSFVMYNLEYKNdqwqdkklKKTVSVLHFTA
|  .|. . | .. .  .  |. ..  .|    |   |. |.    |  | |.|.  . . |  ...  ... . .|| ..         . |  |.. .
PiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeyg.vralrlidletre........arvvkqldlls

WPDHGAPKN----PDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|||....        ..||. .. |  .       ..||...|.||.|.|.|.   ..        .   .|  .|. | . ||.. || .|.  .
wPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 941-1123 1.4e-12 42.2 In-house 80-251 (267) alignment
Range on Protein: 941-1123
Range on HMM: 80-251/267.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPyysEKVGEKMTFGRYTVTtKSintkLENFTDKKSFVMYNLEYKNDQWQDkklkktVSVLHFTA
| | |  ... || ...| ..  |  | . . |.| |    |.|.   .   ||  .|    ||.  .    .  .|..||.  ..      |.. ..  
plkntitdfltvihdqkvpvivlltkvftdnirlfwP...Pkmgqakkyqdltve.hs....lekeendyqiitlelkfknesahn......vtlyyykk

WPDHGAPK---NPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
|      |   .| ...      |     ..|.||.||||.||.. |.  ..   || ....   .  .|. | | |.. .. .|.
wnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1018-1161 2.5e-12 40.9 In-house 76-221 (440) alignment
Range on Protein: 1018-1161
Range on HMM: 76-221/440.0
EYKNDQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCE-S----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFG
.| |  . .    .|.   |. .|||.| ||     | .|.  . |     .  .|||||||.|||| ..|.   .. .      ...|..  .|| |  
dyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpq

AVQSAQQLMYLIVCITKGVMAKEGVLYwrsFDAITYYHEQILADKYHDN
 ||. .|  ..  .. .|... . ..     | ||   |||   . | .
mvqtpeqyafvheavlegllcgdtlil...edditerveqiqwpnphtd

0038934 (Phosphotyrosine protein) phosphatases II 1007-1125 3.4e-12 41.9 In-house 53-171 (194) alignment
Range on Protein: 1007-1125
Range on HMM: 53-171/194.0
TDKKSFVMYNLEYKNDQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTterttNLLS
  .| .  ..| . .  .  ....|     .   .||.|.. . .  |.......       .  |.||| ||.||||||||      |.      ..  
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.....saee

IVCPVRNCRFGAVQSAQQLMYLIV
 .  .| .| ||... ..| .| .
AialfrekRpgaipnqdyleallk

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 949-1126 4.3e-12 40.7 In-house 67-235 (239) alignment
Range on Protein: 949-1126
Range on HMM: 67-235/239.0
HWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGeKmtFGRYTVTTKsintKLENFTDK--KSFVMYNLEYKNDqwqdkklkKTVSVLHFTAWPDHGA
 | .. |    ..  |. .||   .|   |. .    |  .    || .    | | |.|   ..||| ..   ..        . |   ||| |||.| 
fwrmmwqerrcvivmltglieghkkkchqywpdsts.k..ycnlrvtlr....ktevfadyiirtfvmsqvgqtee........ryvyqyhftvwpdkgv

PKNPDYALDIIRFCE--SY--KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
|.     | . |     |       ..||||||||||... |   .. .  ..| ...  |  .|. |   ||...| ... ..
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 949-1125 5.1e-12 40.5 In-house 68-235 (239) alignment
Range on Protein: 949-1125
Range on HMM: 68-235/239.0
HWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGeKmtFGRYTVTTKsintKLENFTDK--KSFVMYNLEYKNDqwqdkklkKTVSVLHFTAWPDHGA
 | .. |    ..  |. .||   .|   |. .    |  .    || .    | | |.|   ..||| ..   ..        . |   ||| |||.| 
fwrmmwqerrcvivmltglieghkkkchqywpdsts.k..ycnlrvtlr....ktevfadyiirtfvmsqvgqtee........ryvyqyhftvwpdkgv

PKNPDYALDIIRFCE--SY--KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
|.     | . |     |       ..||||||||||... |   .. .  ..| ...  |  .|. |   ||...| ... .
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 885-1059 2.4e-11 38.0 In-house 39-189 (297) alignment
Range on Protein: 885-1059
Range on HMM: 39-189/297.0
HTLFLCEPKTMAKLVGFPD--PFINANVMKFG----EISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPY
..  |   .|  || . .    .|||. . |     .. .|.||||.                 ..|.. .| .. . ||.... .| . |    | |||
yrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGpl.................satvddfwtlvaeqdvrvivmvaklqedGrdkcapy

YSEKVGEKMTFGRYTVTTKSinTKLENFtDKKSFVMYNLEYKndqwqdkKLKKTVSVLHFTAWPDHGAPKNPDyalDIIRF
. . |.|... | . |   |  .  ..| |.  .   .| |.       . .. |    | .||||| | . .   |. ||
wpsvvqerlkagdvvvefls..stsdef.drviltelqliyr.......sesrvvrhvqflswpdhGvpsdle...dlvrf

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 941-1123 3.3e-10 34.0 In-house 102-282 (310) alignment
Range on Protein: 941-1123
Range on HMM: 102-282/310.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSeKVGEKMTFGRYTVTTKSINT-KLENFTDKKSFVMYNLEYKNDQWQDKKLKktVSVLHFT
| . |.   | .| |     .  |  | |    |   |.   .|   |.|   ||  |  . ..|      .||  |.   ..  . |.|.  ||.... 
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelr..vslikwp

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
 ||| | | .  ...    ...  .  ..||||||..|....||.|. |.        ..  ..  ... |.  .|.  | ...
nwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 940-1086 3.7e-10 34.1 In-house 111-284 (350) alignment
Range on Protein: 940-1086
Range on HMM: 111-284/350.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFG---RYTVTTKSINTKLENFTDKKSFV-MYNL---EYKNDQWQDKKLKKT
 | .||... . || . .| ..  |.| .| . .|.  |. |   ...|     ..  ..   .. |  .  || ..   |    .  .|. .  ... .
aPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitla

V------SVLHFTAWPDHGAPKNPDYALDIIR---------FCESYK-----TSVLVHCSAGVGRTGTLVAIKY
.        |..  |.| .   ||   | ..          |.||.      ...|||||||||||||||.. .
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDs

subfamily_CG42327_pd Subfamily CG42327 1064-1123 8.6e-09 29.5 In-house 247-307 (319) alignment
Range on Protein: 1064-1123
Range on HMM: 247-307/319.0
KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTE-RTTNLLSIVCPVRNCRFGAVQSAQQLMYL
.  . |||| ||||||...|    |.   .  |. ..  .|  ||. |  ||.. .|  ..
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 878-1127 9.4e-09 29.1 In-house 50-281 (302) alignment
Range on Protein: 878-1127
Range on HMM: 50-281/302.0
ANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGEISWIMaqgpmdgtehleKISKVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrKFAP
.|... ... . .  ... || . || ..||  ..  |..  .             .. .| .  .. .|. | .. |  .  |  |.   | .   .  
knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsi............ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlse

YYSEKVGEKMTFGRYTVTTKsintKLENFTDKKsfVMYNLEYKNDQWQDKKLkktVSVLHFTAWPDHGAPKNPDYALDIIRFC----ESYKTSVLVHCSA
.. .| |.  ..|.  | ..    | |.  ..|   .| .|   .   .  |   ..| ..| |...  |..   .   .       .. . ....    
lfpkksgdykeygkmfvNnr....kVekaeeek..tryviEvlPegcsnsvl...anvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSkn

GVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|.|| |....    ..  ...   |   ||  .|. |  ||.|..| . | ...
GaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 899-1094 1.5e-08 28.4 In-house 86-296 (349) alignment
Range on Protein: 899-1094
Range on HMM: 86-296/349.0
VGFPDPFINANVMKFGEISWIMaqgpmdgtehlEKISKVPPKPkkSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYT--VTT
 | .| .|||| .|. .||                |..  | |  ||.. .. ||    | .|  | .  | . .|.  |. |   . .|         .
sgklddyinanylkltrisvek...........kyiatqaPlP..stvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyi

KSINTK-LENFTDKKSFVMYNLEYKNDQWQDKKLKKTVS----------VLHFTAWPDHGAPKNPDYALDIIR---------FCESY-----KTSVLVHC
 ...   |. .|.|..    .   || . .|. .....            | .  |.| .   ||   |  .          |.. |      ...||||
anvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhc

SAGVGRTGTLVAIKYGIQ-LCTTE
||| ||||.|| . . .. |  ..
saGcGrtGvlvtldlllsileplq

subfamily_CDC14_pd Subfamily CDC14 1054-1120 2.1e-08 28.4 In-house 253-314 (328) alignment
Range on Protein: 1054-1120
Range on HMM: 253-314/328.0
LDIIRFCESYKTSVLVHCSAGVGRTGTLVAIkYgiqLCTTERTTNlLSIVCPVRNCRFGAVQSAQQL
   .. .|. . .. ||| ||.||||||.|  |   |  . | |    ..  .| || | | . || 
kkfleiaekaeGaiavhCkaGLGrtGtLiac.y...lmkhyrfta.aeaiawlricrPGsvigpqqk

PTEN_1 998-1083 2.4e-08 29.0 In-house 55-149 (196) alignment
Range on Protein: 998-1083
Range on HMM: 55-149/196.0
SINTKLENFTDKKSFVMYNLEYKNDQ----WQDKK-LKKTVSVLHFtAWPDHGAPKnPDYALDIIRFCESY------KTSVLVHCSAGVGRTGTLVA
..   |.|.  .. .  .||. . .     .....  |. |..|||  ..|||||   .  .||.. ....      .  ||||| ||.||.||.||
dvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhf.pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_PTPDC1_pd Subfamily PTPDC1 1031-1121 5.9e-08 27.3 In-house 81-166 (182) alignment
Range on Protein: 1031-1121
Range on HMM: 81-166/182.0
KTVSvLHFTAWPDHGAPkNPDYALDIIRFCESY--KTSVLVHCSAGVGRTGTLVAIkYgiqLCTTERTTNLlSIVCPVRNCRFGAVQSAQQLM
. .   .  .|.|.|..   . .|||..  ..   .  | ||| || |||| |.|  |   |  ..| |     .  ||. |  ..|. .|. 
qgiy.vynfgwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliac.y...lvyakrltae.kaiklvrskrpksiqtreqve

PTPc_motif_SM00404 1048-1083 6.7e-08 27.5 In-house 64-99 (140) alignment
Range on Protein: 1048-1083
Range on HMM: 64-99/140.0
KNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVA
|  | .||.|. .|. ...||||| ||| |..||..
kyldkvldfienaekkggkvlVHCqaGvSRSatlii

DSPc Dual specificity phosphatase, catalytic domain 1042-1083 2.3e-07 25.8 Pfam-A 51-92 (133) alignment
Range on Protein: 1042-1083
Range on HMM: 51-92/133.0
PDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVA
 .    |  . | ..|. .|. . .||||| ||. |..||..
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

DSPc Dual specificity phosphatase, catalytic domain 1042-1083 2.3e-07 25.8 In-house 51-92 (133) alignment
Range on Protein: 1042-1083
Range on HMM: 51-92/133.0
PDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVA
 .    |  . | ..|. .|. . .||||| ||. |..||..
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1064-1128 3e-07 24.6 In-house 228-292 (297) alignment
Range on Protein: 1064-1128
Range on HMM: 228-292/297.0
KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
.. .||||||||||.| .|  .  ..    .|  .  .|.  .|. |   ||. .|  .|   . 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_PTEN_pd Subfamily PTEN 999-1122 8.8e-07 24.1 In-house 50-171 (184) alignment
Range on Protein: 999-1122
Range on HMM: 50-171/184.0
INTKLENFTdKKSFVMYNLEyKNDQWQDKKLKKTVSVLHFTawpDHGAPKNP---DYALDIIRFCESYKT-SVLVHCSAGVGRTGTLVAiKYGIQLCTTE
.   ||.   |... .|||   . ... ||... |.|. |.   || .|.     .   || .. |. |.  | ||| || ||||.|..  | .. ...|
vvkflekkh.kdhykiynlr.serkydskkfdgrvavypfd...DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllksllle

RTTNLLSIVCPVRNCRFGAVQSAQQLMY
.... |..   .|     .|.   |. |
kaeealelfaeaRtknkkgvtiPsqrRY

0048567 (Phosphotyrosine protein) phosphatases II 1017-1084 9.2e-07 23.4 In-house 21-97 (157) alignment
Range on Protein: 1017-1084
Range on HMM: 21-97/157.0
LEYKNDQWQDKKLKKTVSVLHFTAWPDHGaPKNP-------DYALDIIRFCESYKTSVLVHCSAGV---GRTGTLVAI
 .....  . . .  .  ..... . |.| | |         .. ......|  .  . |||.||    |||.||.. 
prlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1069-1123 1.8e-06 22.2 In-house 2-56 (69) alignment
Range on Protein: 1069-1123
Range on HMM: 2-56/69.0
VHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
||||.| |||||..||   .    .|.  ...  |  .| ||   |    . |..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 941-1120 2.4e-06 21.8 In-house 13-193 (199) alignment
Range on Protein: 941-1120
Range on HMM: 13-193/199.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWQdKKLKKTVSVLHFTA
| . |.   | .. .   | .  .       .  .. |..        .|  .||||.| || .       ...  |   |.        . .|   ||.
plretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.......ytitaliltnntta.ppstreishyqfts

WPDHGAPKNPDYALDIIRFCES-------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTT--NLLSIVCPVRNCRFGAVQSAQQL
| .. .|.   .   ..   |          . |.|||| | | || .||.  |..     .|.  .|. .   .|..| | . | |. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1068-1121 2.4e-06 21.8 In-house 2-55 (69) alignment
Range on Protein: 1068-1121
Range on HMM: 2-55/69.0
LVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLM
.||||.| |||||..||   .    .|.  ...  |  .| ||   |   .. .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyi

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 941-1120 2.7e-06 21.7 In-house 12-192 (198) alignment
Range on Protein: 941-1120
Range on HMM: 12-192/198.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWQdKKLKKTVSVLHFTA
| . ||   | .. .   | .  .       .  .. |..        .|  .||||.| || .       ...  |   |.        . .|   ||.
plretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.......ytitaliltnntta.ppstreishyqfts

WPDHGAPKNPDYALDIIRFCES-------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTT--NLLSIVCPVRNCRFGAVQSAQQL
| .. .|.   .   ..   |          . |.|||| | | || .||.  |..     .|.  .|. .   .|..| | . | |. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

subfamily_PRL_pd Subfamily PRL 1054-1123 3.5e-06 21.1 In-house 78-142 (151) alignment
Range on Protein: 1054-1123
Range on HMM: 78-142/151.0
LDI--IRFCESYKTSVLVHCSAGVGRTGTLVAIKYgiqlctTERTTNLLSIVCPVRNCRFGAVQSaQQLMYL
|..   .|.|. |..| ||| ||.||.  |||.         |   .    |  .|. | ||. | .|| .|
lellkekfkeepkstvavhcvaGlGraPvlvalal......ieaGmkyedavefirekrrgains.kqlkfl