Gene F54F12.1 in Caenorhabditis elegans

Synonym: CELE_F54F12.1, F54F12.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP097_AA protein Get Run
CeleP097_AA_864-1132 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 849-1145 8.2e-164 538.3 In-house 7-302 (302) alignment 
Range on Protein: 849-1145
Range on HMM: 7-302/302.0
LCTKSPQEWAEGIYDTIWKLDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGEISWIMAQGPMDGTEHLEKISKVPPKPKKSTLEK
|     .|. | .. ...||....|||....||.||..||.||||||||||.|...||||||.|..||.||||||||||||..||.||.|..||||||||
lnktlleefleyveraleklkkktstnlekdiserrkslficepktmaklvdfkndfinanvlkldeikwimaqGpmdGtekkekvskkpivpkkstlek

HWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMYNLEYKNDQWQDkKLKKTVSVLHFTAWPDHGAPK
|||.|.||.|.||.||.|..|....|.|.|||.|||....||||||.|.|..|.||.|||||||..|..|.||..... |.||||..|.|.|||||||||
hwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafsawpdhGapk

NPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEGVLYWRSFDA
....||||..||||||..|||||||||||||||||||||||||.....|.|||||.|||.||.||||..|||.||..|.|||.|.|.||||.|||||
eaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekagvlylrsfda
Y_phosphatase Protein-tyrosine phosphatase 879-1128 2.3e-64 212.4 Pfam-A 1-234 (235) alignment 
Range on Protein: 879-1128
Range on HMM: 1-234/235.0
NISQRRHTLFLCEPKTMAKLVGFPD--PFINANVM---KfGEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVIESDDR
| ...|.. .|.  ||. || | ..   .||||..   |  . ..|..|||.                 |||.|..|... |..| ....|.|. |....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPl.................kstiedFWrmvwqekvkvivmltsleekgre

KFAPYYSEKVGEKMTFGRYTVTTKsintkLENFTDKKSFVMYNLEYKNDQWQDkkLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK----TSVLV
|.|.|..|. .|..|.|...|..|      .. .|.|......||.|......   |..|..||.|.|||||.|..|.  ||.|| .|..|    ..|.|
kcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvV

HCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
|||||||||||.||... .. ...|.....|.||. .|..|.|.|||..|...|. .|.
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 879-1128 2.3e-64 212.4 In-house 1-234 (235) alignment 
Range on Protein: 879-1128
Range on HMM: 1-234/235.0
NISQRRHTLFLCEPKTMAKLVGFPD--PFINANVM---KfGEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVIESDDR
| ...|.. .|.  ||. || | ..   .||||..   |  . ..|..|||.                 |||.|..|... |..| ....|.|. |....
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPl.................kstiedFWrmvwqekvkvivmltsleekgre

KFAPYYSEKVGEKMTFGRYTVTTKsintkLENFTDKKSFVMYNLEYKNDQWQDkkLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK----TSVLV
|.|.|..|. .|..|.|...|..|      .. .|.|......||.|......   |..|..||.|.|||||.|..|.  ||.|| .|..|    ..|.|
kcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvV

HCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
|||||||||||.||... .. ...|.....|.||. .|..|.|.|||..|...|. .|.
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0036941 (Phosphotyrosine protein) phosphatases II 873-1143 5.4e-56 185.4 In-house 33-289 (297) alignment 
Range on Protein: 873-1143
Range on HMM: 33-289/297.0
STNTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGE--ISWIMAQGPMDgtehlekiskvppkpkkSTLEKHWAVIDQYDVGIVAQLASVIES
 .. ..|..  |.. .|. ..|. || . .. .|||. ... .    .|..|||..                 .|.|..|  . ...| ..  | ...| 
vallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp.................ntvedFWrmvweqnvtvIvmltelvel

DDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKlenftDKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES------YK
.  |.|.|.....|| .|.|..|||..|....     .........|| ..    ... ..|| ..|.| |||||.| .|.. ||.|.....       .
grekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg

TSVLVHCSAGVGRTGTLVAIKYGIQLCT---TERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEGVLYWRSF
. |||||||||||.||..|. . .|.     .|.. ..|..|. .|..|.||||. .|...|. .. . .. |. .......
gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllkl
0040438 (Phosphotyrosine protein) phosphatases II 867-1140 6.8e-55 181.9 In-house 31-285 (317) alignment 
Range on Protein: 867-1140
Range on HMM: 31-285/317.0
KLDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFP----DPFINANVMKFG--EISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGI
||| .  .. ..|.. .|.. .|. . .  ||  ..    . .|||. ...      .|..|||.                 ..|.|..|  . ...|..
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.................pntvedFwrmvweqgvtv

VAQLASVIESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFC
.  | .  | ...|.|.|...  ||..|.|..|||..|. .       ........|| ...   ... . || ..|.|.|||||.|..||  ||.....
ivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl...gdsesrtvthfhytgWpdhgvppspdllldfleav

ESY----KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEGVLYW
...    .. ||||||||||||||..|. . .... .|.. .. ..|. .|..| ||||. .|...|. .. . .. |.   ..
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa
0050432 (Phosphotyrosine protein) phosphatases II 871-1132 1.6e-53 177.4 In-house 60-300 (308) alignment 
Range on Protein: 871-1132
Range on HMM: 60-300/308.0
MVSTNTQANISQRRHTLFLCEPKTMAKLvGFPDPFINANVMKFG----EISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLAS
. ... ..|..  |.. .|.  ..  || . .. .|||. ...     .  .|..|||.                 ..|.|..|  . ...| ..  | .
ysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPl.................pntvedFwrmvweqnvrvIvmLtk

VIESDDRKFAPYYSEKVG-EKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWQDKklkKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY--
 .| .  |.|.|. ...| . ...|..|||..|. .       ........|| .| . ..    .|| ..|.|.|||||.| .|.  ||........  
lvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdges...rtvthfhytnWpdhgvPpspeilldflelvrkslp

KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
.  ..||||||||||||..|. . ...  .|.. .....|. .| .| |.||. .|...|. .. . ..
ggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
DSPc_SM00195 872-1129 1.9e-52 173.5 In-house 19-260 (263) alignment 
Range on Protein: 872-1129
Range on HMM: 19-260/263.0
VSTNTQANISQRRHTLFLCEPKTMAKLVGF----PDPFINANVMKF--GEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLA
 ... ..| |. |.. .|.  .|  ||       .. .||||..|.   . ..|..|||.                 .||.|..| .. . .| |.. | 
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.................pstvedFWrmvweekvkiivmlt

SVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLenftdkKSFVMYNLEYKNDQWqdkKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT
.  |.. .| . |. |. |.|.|||...|.... ..|       .......||.....    . ...| ......|||||.|..... |...|.... | 
eeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksks

----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
     ..||||||||||||.|.|.. .. ...| . .. .||. .|. |.|.||. .|..... .| .
tssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 872-1129 1.9e-52 173.5 In-house 19-260 (263) alignment 
Range on Protein: 872-1129
Range on HMM: 19-260/263.0
VSTNTQANISQRRHTLFLCEPKTMAKLVGF----PDPFINANVMKF--GEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLA
 ... ..| |. |.. .|.  .|  ||       .. .||||..|.   . ..|..|||.                 .||.|..| .. . .| |.. | 
teaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.................pstvedFWrmvweekvkiivmlt

SVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLenftdkKSFVMYNLEYKNDQWqdkKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT
.  |.. .| . |. |. |.|.|||...|.... ..|       .......||.....    . ...| ......|||||.|..... |...|.... | 
eeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksks

----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
     ..||||||||||||.|.|.. .. ...| . .. .||. .|. |.|.||. .|..... .| .
tssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0047943 (Phosphotyrosine protein) phosphatases II 871-1127 2.1e-51 170.3 In-house 30-268 (273) alignment 
Range on Protein: 871-1127
Range on HMM: 30-268/273.0
MVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKF--GEISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVI
.  .. ..|..  |.. .|.  ... || . .. .|||. ...   .  .|..|||.                 ..|.|..|  . ...| ..  | ...
ysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl.................pntvedfwrmvweqnvrviVmLtelv

ESDDRKFAPYYSEKVGE-KMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWQDkklKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----
| . .|.|.|.....|| ..|.|..|||..|..|       |.......|| .| . ..   ..|| ..|.| |||||.| .... |..|.....     
elgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkaleal

-YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
  .. |.||||||||||||..|. . ...  .|.. ..|..|. .|..|.|.||. .|...|. ..
psngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 869-1131 9.3e-51 168.4 In-house 47-289 (297) alignment 
Range on Protein: 869-1131
Range on HMM: 47-289/297.0
DvMVSTNTQANISQRRHTLFLCEPKTMAKLVGFP-----DPFINANVMKFGEI---SWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGI
| .. .. ..|.. .|.. .|. . .. || ...     . .|||. ... ..    .|..|||...                 |.|..|  . ...| .
d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.................tvedFwrmvweqgvtv

VAQLASVIESDDrKFAPYYSEKVGekmTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNdqwqdKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFC
.  | . .| .  |.|.|..|..|   |.|..|||.... .       .. .....|| .|     ..  .|| ....| |||||.| .... |......
ivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn.....ngesrtvthfqytgwpdhgvppslellleflelv

ES------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGV
..       .. ||||||||||||||..|. . .... .|.. ..|..|. .|..| ||||. .|...|. .. . .
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 871-1127 2.5e-50 167.3 In-house 47-300 (307) alignment 
Range on Protein: 871-1127
Range on HMM: 47-300/307.0
MVSTNTQANISQRRHTLFLCEPKTMAKLVG-----FPDPFINANVMKF----------GEISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQ
. ... ..|.. .|.. .|. . |  ||        .. .|||. ...              .|..|||...                 |.|..|  . .
ysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.................tvedFwrmlwe

YDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwQDKKLKKTVSVLHFTAWPDHGAPKNPDYALD
..|...  | . .| ...| |.|.... ||..|.|..|||..|...       ........|| ..   . ..   || ..|.|.|||||.|.... .||
qgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......ldgytvrtlevtdl..dgtgesrtvthfhytgwpdhgvppsfeelld

IIRFCES------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERT---TNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
.|. ...       .. ||||||||||||||..|. . ...  .| |    .||..|. .|..| ||||. .|...|. ..
fieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0046845 (Phosphotyrosine protein) phosphatases II 869-1132 4.5e-50 166.0 In-house 18-275 (284) alignment 
Range on Protein: 869-1132
Range on HMM: 18-275/284.0
DVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDP-----FINANVMKFG-------EISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQY
  .  .. ..|.|  |.. .|.  ..  ||  ...      .|||. ...        .  .|..|||...                 |.|..| .. ..
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.................tvedFwrmvweq

DVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDI
.| ..  | . .| .  |.|.|.... ||..|.|..|||..|...       |.......|| .|   . ..  .|| ..|.|.|||||.| .|.  |..
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedllef

IRFCESY------KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTER---TTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
.|.....      .  ..||||||||||||..|. . ...  .|.   . ..|..|. .|..|.|.||. .|..... ..   ..
lrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
0051299 (Phosphotyrosine protein) phosphatases II 872-1128 2.4e-49 163.7 In-house 42-283 (288) alignment 
Range on Protein: 872-1128
Range on HMM: 42-283/288.0
VSTNTQANISQRRHTLFLCEPKTMAKLVG----FPDPFINANVMKF--GEISWIMAQGPMDgtehlekiskvppkpkkSTLEKHWAVIDQYDVGIVAQLA
 ... ..|..  |.. .|.  ..  ||       .. .|||. ...   .  .|..|||..                 .|.|..|  . ...| ..  | 
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp.................ntvedFWrmvweqnvrvIvmlt

SVIESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQ-WQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY-
...| . .|.|.|...  |...|.|..|||..|. .       ........|| .| . .. .. ..|| ..|.|.|||||.| .|.  ||..|.. .. 
klvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

---KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
   .  |.||||||||||||..|. . ...  .|.. ..|..|. .|..|.|.||. .|..... .. 
asgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0045098 (Phosphotyrosine protein) phosphatases II 877-1130 2.4e-47 157.0 In-house 31-271 (278) alignment 
Range on Protein: 877-1130
Range on HMM: 31-271/278.0
QANISQRRHTLFLCEPKTMAKlvgfpDpFINANVMKFGEISWIMAQGPMDgtehlekiskvppkpkkSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFA
  |..  | . .|. . .. |     | .|||. ...    .|..|||..                 ||....|  . .... ..  |....| .  |.|
lgnldknRykdilpydhsrVk.....d.YINAsyidgypkkfIatqgPlp.................stvadfwrmlwelgitvivmltelvelgrekca

PYYSEkvGEKMTFGRYTVTTKSINTKleNFTDKKSFVMYNLEYKNDQWQdkklKKTVSVLHFTAWPDHGAPKNP--DYALDIIRFCES------------
.|. |  |. .|.|..|||..|. .   .   .  . ..|| ..   ..    . .| .||.. |||||.| .|  .. |....|...            
qywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredle....srgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCttERTTNLLSIVCPVRNCRFG-AVQSAQQLMYLIVCITKG
      .. |||||||||||||||||. . ..|.  |.. .||..|. .|..| | |||. .|...|. .. . 
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllel
0043336 (Phosphotyrosine protein) phosphatases II 865-1127 3.9e-47 156.4 In-house 33-273 (278) alignment 
Range on Protein: 865-1127
Range on HMM: 33-273/278.0
IWklDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFP----DPFINANVMKFG--EISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDV
 .  | .  .. ..|.. .|.. .|. . .. ||  ..    . .|||. ...      .|..|||...                 |.|..|  . ...|
kl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.................tvedFwrmvwelgv

GIVAQLASVIESDDRKFAPYYSekvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNdqwQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIR
 ..  | .  | .  |.|.|..   |. .|.|..|||......       .. .....|| .|     .. ..|| ..|...|||||.| ...  ||...
ttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn...lgdgesrtvthyhylgwpdhgvpeslsllldflk

FCES----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
.  .     .. ||||||||||||||..|. . ...  .|.. .|...|. .|..|.||||. .|...|. ..
avrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0040439 (Phosphotyrosine protein) phosphatases II 874-1127 4e-47 156.3 In-house 6-242 (249) alignment 
Range on Protein: 874-1127
Range on HMM: 6-242/249.0
TNTQANISQRRHTLFLCEPKTMAKLVG----FPDPFINANVMKF--GEISWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGIVAQLASV
.. ..|.. .|.. .|. . .. ||      |.. .|||.....      .|..|||...                 |.|..|  . .......  | | 
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.................tvedfwrmlwelgitvivmLtsl

IESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----
 | .  |.|.|...  |. ...|..|||..|...       |.......|| .|     .. . || ....| |||||.|.... .||.|. ...     
velgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel

-YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
  .. ||||||||||||||..|. . ...  .|.. .|...|. .|..|.||||. .|...|. ..
pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 875-1127 3.3e-45 149.8 In-house 5-239 (245) alignment 
Range on Protein: 875-1127
Range on HMM: 5-239/245.0
NTQANISQRRHTLFLCEPKTMAKLVGFP----DPFINANVMKFGEI--SWIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGIVAQLASVI
. ..|.. .| . .|. . |. ||   .    ...|||. ... .|   .|..|||...                 |.|..|  . .... ..  | .  
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.................tvedfwrmlwelgittivmLteee

ESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----Y
| .  |.|.|...  ||..|.|..|||..|...       ........|| .|.    .. ...| ..|.. |||||.| .... ||...|...      
elgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
.. ||||||||||||||..|. . ...  .|.. .| ..|  .|..| ||||. .|...|. ..
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 875-1127 2.6e-42 140.4 In-house 6-238 (243) alignment 
Range on Protein: 875-1127
Range on HMM: 6-238/243.0
NTQANISQRRHTLFLCEPKTMAKLVGfpDPFINANVMKFGEiSWIMAQGPMDGTEHLekiskvppkpkksTLEKHWAVIDQYDVGIVAQLASVIESDDRK
. ..|.| .|.. .|. . .. || |  . .|||| ..  .  .|  |||...| .              .|...|  . .......  | . .| .  |
llpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.rliatqgPlpetved.............dlasfwrmlwelgitvivmltelvElgrek

FAPYYSekvGEKmTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWQDKKlkKTVSVLHFTAWPDHGAPKNPDYALDIIRFCE------------S
 |.|..   ||. |.|..|||..|...       ........|...| ...| .  ..|  .|...|||||.| .|.  ||.....             .
caqywp...gev.tygdftvtllseeh.......lddytvrtlllenldlddlt..rlvihyhylpwpdhgvPdspedlldfldevrefieellsllald

YKTSVLVHCSAGVGRTGTLVAIKYGIQLCtterTTNLLSIVCPVRNCRFG-AVQSAQQLMYLIVCI
 .  |||||||||||||||.|. . ..|.    . .|...|. .|..|.| |||. .|...|. ..
sggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_PTPN12_pd Subfamily PTPN12 941-1131 5e-33 109.2 In-house 91-277 (290) alignment 
Range on Protein: 941-1131
Range on HMM: 91-277/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSintklENFTDKKsFVMYNLEYKNDqwqdkKLKKTVSVLHFTA
|   ||. .| .|....| ||  .  ..| .  | . |..|...|...|| ..||...     |. .|.  |..  |. ...     | ...|  .|.||
PLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.....ekavddd.flirtLkveaq.....kesrkvyqfhYta

WPDHGAPKNPDYALDIIRFCESYKT----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERT---TNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGV
||||| |....  |..|.  .....     ..||||||||||||..|| |  .|  .|..    .. ..|  .|. |  .||. .|  ..  .... |
WPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 941-1127 2.3e-30 100.2 In-house 102-279 (290) alignment 
Range on Protein: 941-1127
Range on HMM: 102-279/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKlENFTDKKSFVMYNleykNDQWQDKKLKKtvsvLHFTA
. |.|    | .. | .|  .  |  .||    | ..|| || || .||| .||.    ..| .. . || . . .     |. ...|||.    |.  .
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddk.daniikktlsvrd....kdsGkehklkh....lkiks

WPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|||.  ..     | ..|        | ||||||.|||||.|||. |.|. .  .  .|| .|  .||.| ..||   | . |.  .
wpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 940-1124 1.3e-29 98.3 In-house 96-276 (305) alignment 
Range on Protein: 940-1124
Range on HMM: 96-276/305.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYKNDQWqdKKLKKTVSVLHFT
 | |.|..  | .| .. |  . .|. ..| .. |   |. |...||. ||...|. || .|        . ... .|.  ...   .| ..||. ...|
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.......asdyieRklkisiede..dkesrtvlqyqlt

AWPDHGAPKNPDYALDIIRFC-ESYKT----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
 ||||| |. .   |..|.   ...|     ..||||||||||||. .|..  .. . .| . ..  ..  .|. | ..||. .| ..| 
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflh
subfamily_PTPRD_pd Subfamily PTPRD 941-1129 1.8e-28 94.5 In-house 99-279 (564) alignment 
Range on Protein: 941-1129
Range on HMM: 99-279/564.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGeKMTFGRYTVTTKSiNTKLENFTDKKSFVmYNLEykndqwqdKKLKKTVSVLHFTA
|...|.|  |  . .... ..  | .. |..  |.. |. || | . |.|..||| .. ...|.... .. ..  . .        .. ...|   |||.
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtlee.eeeladyeirtfkl.kkkk........ssesreVrqFhFts

WPDHGAPKNPDYALDIIRFCESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
|||||.|...   ||.|| .....      ..|||||||||||| ..|.. ..  ..|.| .. ..|  .|. |   ||. .| ...   | .
WPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaile
0041856 (Phosphotyrosine protein) phosphatases II 880-1128 1.3e-27 92.0 In-house 2-168 (182) alignment 
Range on Protein: 880-1128
Range on HMM: 2-168/182.0
ISQRRHTLFLCEPKTMaklvgfPDPFINANVMKFGEIS--WIMAQGPMDGtehlekiskvppkpkksTLEKHWAVIDQYDVGIVAQLAsviesddrkFA-
.. .|.. .|. . ..      .  .||||.. ..  .  .|..|||...                 |.....  . .......  |.            
ldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls.................tvadflrmlkelgittivnlt.........eel

--PyysekvgekmtfgrytvttksintklenftdkksfvmynleykndqwqdKKLKKTVSVLHFTAWPDHGAPKnPDYALDIIRFCESYKTSVLVHCSAG
  |                                                 ..|....  .... |||||.|  .| .||.|. ... .  ||||||||
ywp.................................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaG

VGRTGTLVAIKYGIQLctterTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
|||||||||. . ..|       .| ..|. ||..|.|.|.. .|. .|  .. 
vgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlall
subfamily_PTPN3_pd Subfamily PTPN3 875-1129 1.5e-27 91.2 In-house 37-273 (280) alignment 
Range on Protein: 875-1129
Range on HMM: 37-273/280.0
NTQANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGeIswimaqgpmDGTEHLE-KISKvpPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDR
.  .|.|. |.   |   .|  ||.  .  .|||| ...  |         ..|.     |.     | ..| .. | .. . .. ..  |....|.   
rkpenlsknryrdilpydatrvklkesetdyinanyvnme.i.........pstglvnryiat..qGPlaktatdfWqmvweqksslivmlttlverGrv

KFAPYYSEkVGEKMTFGRYTVTTKSIntklenfTDKKSFVMYNLEYKNDQwqdKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYK----TSVLV
|   |. |  ......|...|. ..          .||.|. .|  |. .   .| ....  | ..|||||| |....  |....  ....    . |.|
kChqyWPe.tedeleygefsvkceke.......detksyvlrelvlkdke...tkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvv

HCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
|||||.|||| |....  ..|  ...  . | ||  .|. |   ||.|.|  ..  .| |
hCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 941-1124 1.5e-27 91.3 In-house 99-276 (290) alignment 
Range on Protein: 941-1124
Range on HMM: 99-276/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMtFGRYTVTTksintklENFTDKKSFVMYNLEYKNDQWQdkKLKKTVSVLHFTA
| ..|| . | .|.| .| |.  | ..||..  |   |.... . |. .| ....         | .  ....  .|| ||.. .  . |..|  ...|.
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikl.......lneetlneyierklevknknsa..gakqsvtqyqitn

WPDHGAPKNPDYALDIIRFCES-----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
|...|  .||   | .|.  .       .||..||||..|||.....|.. .|. | ||   ......   | .. | ||..||. ...
wdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 878-1133 7.3e-27 89.1 In-house 42-273 (288) alignment 
Range on Protein: 878-1133
Range on HMM: 42-273/288.0
ANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKfgeiswimaqgpmdGTEHLEKISkVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAP
|| .. |..   .   |  ||   || .|.|||.                ... ...      | ..|.|. | .. . ||  .  |. ..|   .| | 
anptrdryenlprcditrvklsddpdfyiaanvvs..............sakykrrli.caqaPlngtieelWkmllesdveyivmlcellekGkeksae

YYSEKVGEKMTFGRYTVTTKSINtklenfTDKKSFVMYNLEyKNDQWQDKKLkkTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGR
|.  |.|||. .||.   .|  .      .| .  |   |  .. .  ..|    | .||.  |.|.| |.|    | ..   .|..  ..||.||||||
yfPsklGekarigrlctvvkkkr......adidklvkvsll.riskegeekv..ivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGr

TGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMA
||||. |   ..    .    . |..   |. || |.|. .| .|.  |. . .. 
tgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_PTPRB_pd Subfamily PTPRB 941-1133 8e-27 89.0 In-house 102-287 (293) alignment 
Range on Protein: 941-1133
Range on HMM: 102-287/293.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSintklenFTDKKSFVMYNLEYKNdqwqdKKLKKTVSVLHFTA
|  .|... | .. .  . |.  |  ..|    |   |. ..  | ...|  .|| ..        .... .|. .|. ..     .| ...|  .|||.
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlva.......eeeledwvirelkiek.....ekeerkvrqyhfts

WPDHGAPKNPDYALDIIRFCESYK------TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMA
||||| |....  ||..|  ....      . ..||||||||||||..|..  .|  ..| . ....||. .|. |.  ||. .| ...  |. . .. 
WpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN13_pd Subfamily PTPN13 868-1123 1.4e-26 88.4 In-house 26-261 (273) alignment 
Range on Protein: 868-1123
Range on HMM: 26-261/273.0
LDVMVSTNTQANISQRRHTLFLCEPKTMAKLVGFPDpFINANVMKFGEiswimaqgpmdGTEHLEKISKVPPKPKksTLEKHWAVIDQYDVGIVAQLASV
||   ......| .. |.   |   .|  || .    .|||. .|              | .. | |    | |.  | .  | .. . .. ..| ... 
ldtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv...........gkdeyeyiacqGPlPe..tvkdfwqmvweqkaeviamvtle

IESDDRKFAPYYSEKVGEKMTfgrytvTTKSINTKLENFTDKKSFVMYNLEYKNDQWQDkklKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT--
 |..  |   |. |. ..|..       .  .. .|.. .....||. .|. |. . ..    . |. |.|..||||| |....  | ...   . .|  
kekgkvkchrywPesknkklk......vsnrlevellkvqkldgfvvralavkdsesge...srevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

-SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
  ..||||||.||.|||..|.  ..|   ..  ..  ||  .|. | | ||. .| .. 
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv
0043147 (Phosphotyrosine protein) phosphatases II 918-1124 1.7e-26 88.4 In-house 22-154 (172) alignment 
Range on Protein: 918-1124
Range on HMM: 22-154/172.0
WIMAQGPmdgtehlekiskvppkpKKSTLEKHWAVIDQYDVGIVAQLASViesddrkfapyysekvgekmtfgrytvttksintklenftdkksfvmynl
.|. |||                   .||...|. . .......  | .                                                   
fiatqgp.................lrntladfwrmlkelgithivnltel..................................................

eykndQWQDKKLKKTVSVLHFTAWPDHGAPkNPDYALDIIRFCES-----YKTSVLVHCSAGVGRTGTLVAIKYGIqlctteRTTNLLSIVCPVRNCRFG
     .   ..|....  .... |||||.| .... |....|...      .  |||||||||||||||||. . .      .  .|. .|. ||..|.|
.....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpg

AVQSAQQLMYLI
|||. .|...| 
avqnpsqyrfly
0036282 (Phosphotyrosine protein) phosphatases II 919-1124 6.5e-26 86.5 In-house 20-163 (174) alignment 
Range on Protein: 919-1124
Range on HMM: 20-163/174.0
IMAQGPMDgtehlekiskvppkpkkstlekHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEkvgekmtfgrytvttksintklenftdkksfvmynle
|  |||..                      .|. . .... .| .| . .| .  |.  |..|                                     
iagqgpla......................fwemlkelgittvvmlleekelglykcinywpe.....................................

ykndqwQDKKLKKTVSVLHFTAWPDHGAPKNPDyALDIIRFCESY-----KTSVLVHCSAGVGRTGTLVAIKYGIQLCTtERTTNLLSIVCPVRNCRFGA
        . |....  .... |||||.|  .   |....|.|..     .  |||||||||||||||||. . ...   |.. . |..|  .|..| |.
......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VQSAQQLMYLI
||. .|...| 
vqtpsQyrfly
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 941-1129 9.2e-26 85.5 In-house 98-277 (288) alignment 
Range on Protein: 941-1129
Range on HMM: 98-277/288.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTkLENFTDKKSFVMynleykndqwqDKKLKKTVSVLHFTA
|  .|... | .. ....  .. |....| ...|   |. .. ...  .|  ||| .. .. ||.|. .|  .             || . ..  ....|
PladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveske.ledfvlrkllle...........kkkteleitqyqyla

WPDHGAPKNPDYALDIIRFCESYKTS----VLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
||||| |..    |...|  .  ...    ..|||||||||||| .|..  |.   .| . .....|. .|. |.  ||  .| ...  .. .
WpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 905-1126 2.3e-25 84.1 In-house 50-259 (270) alignment 
Range on Protein: 905-1126
Range on HMM: 50-259/270.0
FINANVMKfgeiswimaqgpmdGTEHLEKISKVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFgrytvTTKSINTKLE
.|||| ..              | .. .|       |...||...| .| .  |  .. .. . |   .| . |......||...     ..  |..  .
YinAnyvr..............GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl.....edgkikvlal

NFTDKKSFVMYNLEYKnDQWQDkklKKTVsVLHFTAWPDHGAPKNPD---------YALDII-RFCESYKT--SVLVHCSAGVGRTGTLVAIKYGIQLCT
. . .. ... .|. . .. .    .. |   ....|||||.|...|         . |  . |.... .    .||||||||||||||.|. ....|  
seekeegyiltrlrle.ekgee...rrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLe

TERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
...  ..|.|.  .|. |   ||  .|  .|   
etkkvdvlaiieelRkdRmalvqhpeqyeflyka
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 940-1124 4.5e-25 83.3 In-house 89-270 (307) alignment 
Range on Protein: 940-1124
Range on HMM: 89-270/307.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVmyNLEYKNDQWQDKklKKTVSVLHFT
 |...|  . ||.. | .|  |  |. |||    |   |.  . |.|..||  . |    |   ....  . ..  |.   . .| .|   .|.. | ..
gplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli..nvttlkvdwaqk..srtiqhlqwe

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGI-QLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
 |||.|.|.    |....   .  .  |.|||||||||.||.||| .   .. . .   ..  .|  .|. |  |.|.  | .|| 
nwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 940-1128 6.2e-25 83.0 In-house 106-287 (298) alignment 
Range on Protein: 940-1128
Range on HMM: 106-287/298.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGRYTVttksintKLENFTDKKSFVMYNLEYKNDQWQdkkLKKTVSVLHFT
.| ..|.|  | .. ..|.| .  | .. |.|  |.  |. ..  .| |.|. ||       .| .  ..  ... .|. .. . .    ...|  ||||
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv.......sllskeefadlivrklkvskkkee...kerevrqlhft

AWPDHGAPKNPDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
 |||.|.|.|    ||..|  . ..     ..|.|.|||||||.|| .||.  ..   .|..  .. .|  .|. | ||||. .| ...   . 
sWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
PTPc_DSPc_SM00012 1032-1127 7.7e-25 82.5 In-house 1-103 (105) alignment 
Range on Protein: 1032-1127
Range on HMM: 1-103/105.0
TVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKT------SVLVHCSAGVGRTGTLVAIKYGIQLCTTE-RTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
||...|.|.|||||.|...|  |...| ... |.      .|.||||||||||||.||. . .| ...| .. ... ||. .|. | |.||. .| ..|.
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

VCI
 ..
ral
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 940-1128 8.1e-25 81.9 In-house 93-273 (515) alignment 
Range on Protein: 940-1128
Range on HMM: 93-273/515.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFtdKKSFVMYnleyKNDQwqdkklKKTVSVLHFT
 |.|....  | .. |..|  .| ..   |.|  | . |. .| |. . || . | . |...  .    |. . .     |.|.       .||   |||
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggi..krkltvl....kgdd......srtvtqfhft

AWPDHGAPKNPDYALDIIRFCES----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
 |||.|.||.    | .|.   .    |. ....|||||||||| ...|.  .    | |. ... .|  .|. |   ||  .|  ..   . 
eWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 941-1124 9.1e-25 82.3 In-house 81-261 (274) alignment 
Range on Protein: 941-1124
Range on HMM: 81-261/274.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMT--FGRYTVTTKSINTKlENFTDKKSFVMYNLEYKNdqwqdkklkktVSVLHF
|  .|..  | .| | .| ..  |. . |.. .| | |. .. . ...  .|   .....|... .... .|  . |  . ..           |    .
PlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekiver.ndysvrklvlkylerers...........vkhywy

TAWPDHGAPKNPDYALDIIRFCESYK-------TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
|.|||| .|....  ||...  |. .       ..|.||||||.||||  .||. ...    | . ..|.||| .|  | | ||...|  .. 
tdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelih
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 941-1126 2e-24 81.1 In-house 94-273 (287) alignment 
Range on Protein: 941-1126
Range on HMM: 94-273/287.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGekMTFGRYTVTtksintkLENFTDKKSFVMYNLEYKNDQWQDKklKKTVSVLHFTA
|  .|. . | .||.  | ..  |.   |.|...   |..|.    ...| |...       | | . ...... .|| ||.. ...  |..|   ..|.
PmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeynie.......llneevnagyierklevknknkagd..kqqvkqyqitn

WPDHGAPKNPDYALDIIRF--C---ESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
|...|  ..|   | .|         . .||..||||..|||.....|.  .|. | || . ......   |  . |.|| ..| ....  
WdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindi
subfamily_PTPRA_pd Subfamily PTPRA 941-1123 2.2e-24 80.9 In-house 109-287 (330) alignment 
Range on Protein: 941-1123
Range on HMM: 109-287/330.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGeKMTFGRYTVTTKSiNTKLENFTDKKSFVMyNLeykNDQwQDKKLKKTVSVLHFTA
||. |.|  | .| ...   .  |. . | .. | | |. .. |  .|.|  .|. .  .| |...| .|  |  .|   .|. ...| .. |. .|||.
PkeetvedfwrmiweqksativmltelkerkeekcaqywPde.G.lvtyGnirveved.etvlvdytvrkflvq.ql...pda.trekksrlvrqfhfts

WPDHGAPKNPDYALDIIRFCES----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
||| | | .|   |....  ..    .  .. ||||||||||||.....  ..   .||  ..  .|  .|. |   ||. .|  ..
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefi
0049260 (Phosphotyrosine protein) phosphatases II 941-1124 2.6e-24 81.1 In-house 17-143 (152) alignment 
Range on Protein: 941-1124
Range on HMM: 17-143/152.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYsekvgekmtfgrytvttksintklenftdkksfvmynleykndqwqdkklkktvsVLHFTA
|   ||...|  . .......  | .  | .  |.. |.                                                         ... 
pgpntladfwrmlkelgittivmltellelgklkceqyi.......................................................qylhlp

WPDHGAPKNPDYALDIIRF----CESYKTSVLVHCSAGVGRTGTLVAIKYGIqlctteRTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
|||||.|..... |....|    ... .  |||||||||||||||||. . .      .  .|. .|  ||..| |||.. .||..| 
wpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_PTPRG_pd Subfamily PTPRG 940-1152 3.1e-24 80.1 In-house 98-311 (563) alignment 
Range on Protein: 940-1152
Range on HMM: 98-311/563.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEkvGEKMTFGRYTVTTKSINTKleNFTDKKSFVMYNLEYKNDQWqdKKLKKTVSVLHFT
.| |.|..  | .| .  | |.  .. . |.  ||   |. .   | .|.|  .|| .. ...      ....|. ||. |. .   .. .|.|   |.|
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevl..alytvrtlviknlklkkkkq..cdteklvrqyhyt

AWPDHGAPKNPDYALDIIRFCESYKTS----VLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKE
 |||||.|. . . |  ..  .  . .    ..||||||||||||.....  ..   .| . |.. ..  .|  |   ||.  | ..|   . . ...||
kWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaske

GVLYWRSFDA---ITYYHEQ
  |     ..   .| | ||
tellaeqveelknctpyleq
0046846 (Phosphotyrosine protein) phosphatases II 941-1127 4.2e-24 80.7 In-house 31-169 (176) alignment 
Range on Protein: 941-1127
Range on HMM: 31-169/176.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMtfgrytvttksintklenftdkksfvmynleykndqwqdkklkktvsVLHFTA
|  .||.. .. . ......|  | . .| .  |.. |..|  ....                                                 ... 
plprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................................qylhlp

WPDHGAPKNpDYALDIIRFCESYK---TSVLVHCSAGVGRTGTLVAIKygiqLCTTERTTNLLSIVCPVRNCRF-GAVQSAQQLMYLIVCI
|||||.|   .. |....|....      ||||||||.||||||||.     |. .|.  ... ... ||..|. ||||. .|. .|  ..
wpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefe
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 925-1137 5.2e-24 79.7 In-house 69-275 (285) alignment 
Range on Protein: 925-1137
Range on HMM: 69-275/285.0
MDGTEHLEKISKVPPKPkkSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMYNLEyknDQW
| | ..   |.   | |   ||   | .| |  .  |  |....|    | | || ||.|| . ||.| .|    . .    |  ... . | |   |  
mpgkdqstyittqgplp..etlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvinte...das

QDKKLKKTVSVlhfTAWPDHGAPKNPDYALDIIRFCE---SYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLM
 .    . | |     |||. ||..    ... .. .     .. . |||||||||| |.| | |       .   ..| ||  .|  || ||||  |..
seplymnhvqv...pwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqfl

YLIVCITKGVMaKEGV
.| | . . ..  |||
flyvvlmeyfi.gegv
0051429 (Phosphotyrosine protein) phosphatases II 944-1129 7.1e-24 80.3 In-house 33-223 (272) alignment 
Range on Protein: 944-1129
Range on HMM: 33-223/272.0
STLEKHWAViDQYDVGIVAQLASVIESDDRKFAPYYS----------EKVGEKMTFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWQDKKlkKTV
 | .  |.   ....  .  | |. | .  |. .|            . . . ...|...||. |. ..|        .....|....    ..    .|
ltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld.......yilrellltlllsagea..rev

SVLHFTAWPDHGAPKNPdyALDIIRFCESyKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTN--------LLSIVCPVRNCRFGAVQSAQQLMYLIV
 .||.|.|||||.|...   |...... . .  ||||||||..||||.||. . ..  . |   .        |. .|  .| .| ||||. .|...|  
mhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

CITK
.. .
alle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 939-1125 1.9e-23 77.6 In-house 96-275 (301) alignment 
Range on Protein: 939-1125
Range on HMM: 96-275/301.0
PKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMynleyKnDQwQDKKLKKTVSVLHF
  | |.| |  ||.. ||||  .. |.  .|   .| . |.. |..||.  ||.....|. .. |.. . |... .     . |   .|   .||    .
qgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlev.....e.ds.tgkfatrtvthyqy

TAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
. |.|.| ||      |.. .    .  ..||||||.||. .... .|  .   ...| .|   .  .|. |. .||  .|| .. .
sewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 941-1129 2.2e-23 77.7 In-house 92-274 (281) alignment 
Range on Protein: 941-1129
Range on HMM: 92-274/281.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVgEKMTFGRYTVTTKSINtklenftDKKSFVMYNLEYKNDQWQdkklKKTVSVLHFTA
|  ..|.. | .. ...| ... ..  ||..  |   |. ..  .....| .||.... .       .|....  ... .... .    ...|. |..||
PvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn.selkygdvtvkstaee.......ekatyierkfkleresge....treveqlayta

WPDHGAPKNPDYALD----IIRFCESYK-TSVLVHCSAGVGRTGTLVAIKYGIQLCTTE-RTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
|||||.|...   |.    . .. |. . .....||||||||||| .|.   .. ...| .....  .|  .|. |   ||.  |  ..   . .
WPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 940-1129 2.7e-23 77.5 In-house 59-240 (250) alignment 
Range on Protein: 940-1129
Range on HMM: 59-240/250.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRkFAPYYSEKVgeKMTFGRYTVTTKSIntklENFTDkksFVMYNLEYKNDQwqdKKLKKTVSVLHFT
.| ..|.|. | .. ....| .  |... ||.   .  |.  ..    ..|  ||. .|     |.|.|   ... .|   . .   |. ...|  |||.
gPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyGdvtvsllsk....eefad...ytkrklklskak...kaderivrqlhfv

AWPDHGAPKNPDYALDIIRFCESYKTS-----VLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
.||| | |..   .|....  .. .       |.|.|||||||.|. .||.  ..   .|.. ..  ..  .|. | .||.| .| ...   | |
vWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 940-1130 2.7e-23 77.3 In-house 94-276 (315) alignment 
Range on Protein: 940-1130
Range on HMM: 94-276/315.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTdKKSfVMYNleykNDQwqdkklKKTVSVLHFT
 |.|....  | .. |..|  .. ..   |.|  | . |. .. .. . || . |.. |...  .  . .|  |. .     ..      ..||.  .||
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgva.rkl.vtrk....see......srtvtqfqft

AWPDHGAPKNPDYALDIIRFCE----SYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG
 |||.|..|.    | .|.       ... |.|||||||||||| ...|.  ..    .|. ... .|  .|. |   ||. ..  ..   . . 
ewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 941-1131 4.1e-23 76.9 In-house 97-280 (318) alignment 
Range on Protein: 941-1131
Range on HMM: 97-280/318.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGRYTVTtksintkLENFTDKKSFVMYNLEYKNdqwQDKKLKKTVSVLHFTA
|   |.|  | .. . .  ..  |. . |.  .| . |. .|  . ...|. .|.       |.. .. ...|. ... ..   .... ...|   |.|.
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvve.......lkeevelsdyvlrefkvtr...teeeesrqvrqyhyts

WPDHGAPKNPDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGV
|||.| |...   ||..|  ....     . ..|||||||||||. .|..  ..    | . ... .|  .|. |   ||  .|  ..   ... .
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_PTPN6_pd Subfamily PTPN6 943-1129 4.7e-23 76.6 In-house 108-295 (306) alignment 
Range on Protein: 943-1129
Range on HMM: 108-295/306.0
KSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMtFGRYTVTTKSINtklenftDKKSFVMYNLEYKNDqwQDKKLKKTVSVLHFTAWP
..|..  | .. | .  ..  .   .|    | |.|. ..  ... .|...||. | .       ....... .|  ..   ..|| ...|  .||..||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.......sladYilRelsvskk..kkkkeerevfqyhfksWP

DHGAPKNPDYALDIIR----FCESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTT---ERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
||| ||.|.  || ..      |. .     ...||||||.|||||.. |   ..| ..   .  ... ..|  ||. | | || .||  ..   |.|
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikk
subfamily_Ptp69D_pd Subfamily Ptp69D 941-1125 5.1e-23 76.7 In-house 99-280 (307) alignment 
Range on Protein: 941-1125
Range on HMM: 99-280/307.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGrytvttkSINTKLENFTDKKSFVMYNLEYKNDQ--WQDKKLKKTVSVLHF
|  .|..  | .| . .| ..  |. . | ...| | |...   ... .|       .|. || ..  .. ... .|.. . .    . . .. |   |.
PveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.......dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhy

TAWPDHGAPKNPDYALDIIRFC-ESY---KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
|.|.|  .|. .   |..|.   | |   .. ..|||||||||.|..||..  .| . .| . ..  .|. .|. |   ||| .| ..|  
tgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 941-1125 5.9e-23 76.3 In-house 100-273 (315) alignment 
Range on Protein: 941-1125
Range on HMM: 100-273/315.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgeKMTFGRYTVTTKSINTKlENFTDKkSFvmynleyknDQWQDKKLkKTVSVLHFTA
|. ....  | .. ..|.| .  |....| . ||   |. .|   |...|..||| || . . ...| . ..             .... ..|  ||.|.
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevn.teytvr.tl.........svvfgdni.revvqlhyts

WPDHGAPKNPDYALDIIRFCESYKT----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
||| | ||     ...||    ..|    ...||||||||||||.....  ..   .|.  ..  ..  ||. | ..||.|.|  ..  
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 940-1135 9.4e-23 75.8 In-house 99-288 (297) alignment 
Range on Protein: 940-1135
Range on HMM: 99-288/297.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrKFAPYYSEKVgeKMTFGRYTVTTKSINtklenftDKKSFVMYNLEYKNDqwqDKKLKKTVSVLHFT
.|.|.|..  ||.. ...| ... |.   |.|. | | |.|.|    .|||  .|...|..       ... |.  .|| ...   . | .. |   .|.
mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGdvsvvllsvs.......ereGfikrelevtkg...kakarrvvkqyqfv

AWPDHGAPK--NPDYALDIIRFC-ESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
 |||.  ..  .  . |..|    ....    . .||||.||||||| |..|.  .     | . ... .|  .|. |   ||  .|  .. | . . ..
eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

AKE
...
sed
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 901-1137 1.8e-22 74.8 In-house 44-257 (290) alignment 
Range on Protein: 901-1137
Range on HMM: 44-257/290.0
FPDPFINANVMKF-GEISWIMAQGPMDGTehlekiskvpPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDR--K--FAPYYSEKVGEKMTFGRYTVT
| | .| || ...   .  |. | |   .           . ..||.||.| .. |  |  | .|  . | .    .   | |. |.|||...|.  || 
fnddyiHAnrvtcpnglrliltqsPqeki..........tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvk

TKSINTKlENFTDKKSFVMYnleykndqwqDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCT-TE
 ||  .. ...  ..  | .          |.. . ||    .  | .  .....  .|..|.. . .|| |.|||  |. |  .| ||. | |.   |.
Ckskeke.ddvetRelvvkf..........ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaets

RTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITkgvmakegV
  ..| ...  .|. |  |..||..| . .  |         .
gsvkledvlkalrkqralaitsalelafvdagiv........l
subfamily_PTPN23_pd Subfamily PTPN23 941-1134 1.9e-22 74.4 In-house 91-286 (288) alignment 
Range on Protein: 941-1134
Range on HMM: 91-286/288.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTklenftdKKSFVMYNLEYkndQWQDKKLKKTVSVLHFTA
|..|||   | .. .  . ..  | |  | .. | . |. |. || ..|| ..|| || ..        . .| ..|.    . .|.. .|.|| |..|.
PlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.......tethvervlkl...etldadavksvshlqlts

WPDHGAPKNPDYALDIIRFCES--------YKTSVLVHCSAGVGRTGTLVAIKYGIQLC-TTERTTNLLSIVCPVRNCRFGAVQSAQQLMY---LIVCIT
||..|.|. |.  |...   ||         || ..|||||||||||..  .   ..   . .  .... .|  .|. |   ||  .||      ... .
WpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

KGVMAK
. |. |
rrvldk
0048076 (Phosphotyrosine protein) phosphatases II 983-1127 1.9e-21 71.7 In-house 7-139 (145) alignment 
Range on Protein: 983-1127
Range on HMM: 7-139/145.0
VGEKMTFGRYTVTTKsintkLENFTDKKSFVMYNLeykndQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY---KTSVLVHCSAGVGRTG
. ... .| .... .     ||.. | .    .||         . |....  .... |||||.|  ... |....|.|..   .  |||||||||||||
ilpglylgslptald.....lellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtg

TLVAIKYGIQlctteRTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
||||.   ..     .  .| ...  ||..|.|||.. .|| .|. ..
tlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe
subfamily_PTPN1_pd Subfamily PTPN1 941-1132 2.1e-21 70.9 In-house 79-272 (290) alignment 
Range on Protein: 941-1132
Range on HMM: 79-272/290.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVG-EKMTFGRYTVTTKSINTKlenftDKKSFVMYNLEYKNDQWQDkklKKTVSVLHFT
|  .| .  | .. . .   |  |  |.| .  | | |. ..   .....   ... | |...     .|. ...  || .| . |.    ....  |.|
PlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklisee.....rksyytvrllelenlktqe...treilhfhyt

AWPDHGAPKNPDYALDIIRFCE---S---YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTER---TTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG
.||| | |. | . |. .  .    |    .  ...|||||.||.||.. .   . |   .    . ..   .. .|. |.| .| |.|| .  . | .|
twpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

VM
. 
ak
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 940-1129 2.2e-21 71.3 In-house 98-281 (319) alignment 
Range on Protein: 940-1129
Range on HMM: 98-281/319.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgEKMTFGRYTVTTKSiNTKLENFTDKKsfvmYNLEYKNDQWQDkklkKTVSVLHFT
 |.. |.|  | .. .... ||  |. . |  . |.  |..|.  . ...||..|| .. . .||..  .|     .|. |... .     ..|.  ..|
aPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtlee.eeeledyiirk....lklnkkssevet....Revkhfqyt

AWPDHGAPKNPDYALDIIRFCESYKT-----SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
.||||. |..    ||...  .  .       . |||||||||||| ....  ..    | . .. |.|  .|  |   ||  .|  ..   . .
eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 941-1124 1.1e-20 68.5 In-house 104-282 (305) alignment 
Range on Protein: 941-1124
Range on HMM: 104-282/305.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLENFTDKKSFVMYNLEYKNDQwqdkklKKTVSVLHFTA
|   |... | .. |  |  .  |.  .|    | | |.    |||...    |  .   .|  .   .    . || |  ||      | .|  |..| 
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdq......kmsvrhlqwte

WPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTT-ERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
||| | |     .|...      |  ..||||||.|||||.|||.| ..  .   .   .  .|  .|. |  ..|.  | ... 
wpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfih
0048179 (Phosphotyrosine protein) phosphatases II 1027-1124 1.2e-20 69.2 In-house 43-138 (144) alignment 
Range on Protein: 1027-1124
Range on HMM: 43-138/144.0
KKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESY---KTSVLVHCSAGVGRTGTLVAIKygiqLCTTERtTNLLSIVCPVRNCRFGAVQSAQQLMYL
  |....  .... |||||.|  ... |....|.|..   .  |||||||||||||||||.     |. ...  .| ...  ||..|.|||.. .||..|
efleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfL

I
.
l
0044763 (Phosphotyrosine protein) phosphatases II 947-1126 9.5e-20 66.4 In-house 38-166 (178) alignment 
Range on Protein: 947-1126
Range on HMM: 38-166/178.0
EKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGekmtfgrytvttksintklenftdkksfvmynleykndqwqdkklkktvSVLHFTAWPDHGA
..... . ..... .  |.. .|    |  ||. |. |                                                    ... .||||.
addlellkelgithivnlteelelgflkcdpywpeeag.................................................iqylhipipDhgv

PKNPDYALDIIRFCE----SYKTSVLVHCSAGVGRTGTLVAIKYGIQLctterTTNLLSIVCPVRNCRFgAVQSAQQLMYLIVC
|  ... |....|.|    . .  |||||||||||.|||||. . ..|       .| ...  ||..|. .|..  || .|. .
pdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef
0049772 (Phosphotyrosine protein) phosphatases II 905-1123 1.1e-19 66.8 In-house 74-272 (314) alignment 
Range on Protein: 905-1123
Range on HMM: 74-272/314.0
FINANVMKFGeISWIMAQGpmdgtehlekiskvppkPKKSTLEKH----------WAVI--DQYDVGIVAQ---------------------LASVIESD
.|||. ..    ..| .||                 |.. |..            | ..  ....| ..                       | .. .  
yinasyvdgf.lkfIatqg.................pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng

drkfapyysekvgeK---------MTfgrytvttksintklenftdkksfvmynleykNDQWQDKKLKKTVSVLHFTAWPDHGAPkNPDYALDIIRFCES
                        .                                 . .. ........  .. . .||..||  ... .....|.|.
..............neptaadlellk................................eelydpelferlgikylripvpDgsap.lledfdeflefiee

--YKTSVLVHCSAGVGRTGTLVAIKYGIQLCtterTTNLLSIVCPVRNCRF-----GAVQSAQQLMYL
   .. |||||.||.|||||.|.. | . |.      .|  ..  ||..|.     |.... .|. . 
adkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi
0051082 (Phosphotyrosine protein) phosphatases II 941-1126 1.2e-19 65.9 In-house 23-148 (151) alignment 
Range on Protein: 941-1126
Range on HMM: 23-148/151.0
PkkstleKHWAVIDQYDVGIVAQLASVIESDdrkFAPYYSEKVGekmtfgrytvttksintklenftdkksfvmynleykndqwqdkklkKTVSVLHFTA
.       ... . ....  .  | |  | .   . | | .. |                                               .|  .... 
a......dflellkelgiktivnlrseeerg...ycpeylpelg..............................................ievlhipild

WPDHGAPKNPDYALDIIRFCESY-KTSVLVHCSAGVGRTGTLVAIKYGIqLCttertTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
|||.| | ..| .|........  .  ||||||||.||||||||.   . |       .| ...  .| .|.|.||. || .... .
wpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 940-1137 6.8e-19 63.3 In-house 111-298 (319) alignment 
Range on Protein: 940-1137
Range on HMM: 111-298/319.0
KPKKSTLEKHWAVIDQYDVGIVAQLAsviesdDRKFAPYYSEKVGEKmtFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQwqDKKLKKTVSVLHFT
 |.. ||.  | .| .|..  .  |.        | . |.  |. .|   .|. |  .|..   |       .|. ..|  .|    .| .. .   || 
GPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveetae.......yvvrdielsedg..kekdirkitqfhfl

AWPDHGAPKNPDYALDIIRF------CESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG-VM
 |||.| |. |   . ...        |  .....|||||||||||. ....  ..    |.  ..  .|  .|. |   ||.  | ... . . .  ..
GwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlf

AKEGV
..  |
ghsdv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 941-1153 1.1e-18 62.7 In-house 76-275 (284) alignment 
Range on Protein: 941-1153
Range on HMM: 76-275/284.0
PKKSTLEKHWAVIDQYDVGIVAQLAsviesdDRKFAPYYSEKVGEKmtFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWqdKKLKKTVSVLHFTA
|.. ||.  | .| .|..  .  |.      . | . |.  |. .|   .|. |  .|..   |       .|. ..|  .|    .| ....   ||  
PldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveesee.......yvvrdielsedgk..ekdirkirqfhflg

WPDHGAPKNPDYALDIIRF------CESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAK
|||.| |. |   . ...        |  .....|||||||||||. ....  ..    |.  ..  .|  .|. |   ||.  | ... . . .  .  
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

EGVLYWRSFDAitYYHEQI
   .    | |  |..|. 
hsdvalpdfpa..yleels
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 939-1128 4.2e-18 60.1 In-house 91-290 (301) alignment 
Range on Protein: 939-1128
Range on HMM: 91-290/301.0
PKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSiNTKLENFTDKKSFVMYNLEYK----NDQW--QDKKLKKT
  | |.||   | .| |. .  .  ..   |.   |   |...   |. .||  ||| .. .. . .|. ..  |. .   .    . ..  . .|  ..
qgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvn.eqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswd

VSVLHFTAWPDHGAPKNPDYALDI-----IRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|  |. | ||..|  ..|   | .     .|     .  |.||||..|.|.|. ...  |.  |  |   ..  ..  ||  . |||.  .| . .   |
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvi

T
.
d
subfamily_PTPRK_pd Subfamily PTPRK 939-1144 4.4e-18 60.2 In-house 92-290 (314) alignment 
Range on Protein: 939-1144
Range on HMM: 92-290/314.0
PKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvgeKMTFGRYTVTTKSINTKLENFtdKKSFVMYNleykndQWQDKKLKKTVSVLHF
 .|...|..  | .. ...   .  |. ..|    |   |. |.    ...|   |.  . ... |    .. | ...        . .. ...|  ..|
qgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed...tevygdikvelvetellaelv..vrifrvek......largqeeirevrqfqf

TAWPDHGAPKNPDYALDIIRFCESYK----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAK
..||||. |..    |...|  .. .      ..|||||| ||||| .||.  ...  .|.. ..  .|  .|. .   |.  .| ...   |   ... 
lgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcg

EGVLYWRSFD
|  .    | 
etaipvsefk
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 938-1128 6e-18 59.5 In-house 96-276 (439) alignment 
Range on Protein: 938-1128
Range on HMM: 96-276/439.0
PPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrkfapYYSEkvGEKMTFGRYTVTTKsINTKLENFTDkKSFVMYNleyKNDQwqDKKlKKTVSVLH
 . ||| | .. | .. .  .  . .|. ..||       |.     ... .|  .| .   | .| |..  . | ..|   . |.   .| ..||  .|
tqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps..daevcygdiavrvd.rnielpnyvi.rgfkvfn...erdt..tek.ertvlqfh

FTAWPDHGAPKNPDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
..||||.  | .  . || .|  .| .       |.||||||||||||..|.   ..   .|   ..  ||  .|. |   ||.  | ...  .. 
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 941-1144 1.3e-17 58.9 In-house 99-301 (325) alignment 
Range on Protein: 941-1144
Range on HMM: 99-301/325.0
PKKSTLEKHWAVIDQYDVGIVAqLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSIntklENFTDkksFVMYNLEYKNDQwqdKKLKKTVSVLHFTA
|. .|..  | .. ..   .|  .  ... .. . | |. ...|.  |||   |  ..|    |...|   .|.  |. |. .   |   ..|  ... .
PltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrti....eeisd...yvhrvldvkqvk...kGetrsvkqfqlqs

WPDHGAPKNPDYALDIIRFCE----SY------KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKG
|.| | .| |   . |..  .             | .||||||||||||.....   ..   .|   ...  |  .|. |   |... | . .  .... 
wddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea

VMAKEGVLYWRSFD
.|. .  .   ||.
ymsgntdvpvssfe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 941-1151 2.3e-17 57.7 In-house 90-294 (312) alignment 
Range on Protein: 941-1151
Range on HMM: 90-294/312.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEkMTFGRYTVTTKSInTKLEN---FTDKKSFVMYNLEYKNdQWQDKKLKKtvsvLH
| ..|  . | .        .  |....|    | | | |. ||  . .  . | |..  |..|      || .  . ..  |    |. ||..      
plentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf.vdledhrvyteyc.teieiggkskdkithrvlkvvvka.tgqesklnh....yq

FTAWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMAKEgv
...||||| |   | || ..      |  |. ||||||||||||. |.  |      |  |.  .   .|. |  .|.   | .| . |. . ...|   
waswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg..

LYWRSFDAITYYHE
|| |. .  | ..|
lykrneqewtkfke
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 942-1124 4.9e-17 56.6 In-house 97-280 (305) alignment 
Range on Protein: 942-1124
Range on HMM: 97-280/305.0
KKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFG--RYTVTTKSINTKLENFTDKKSFVMYNLEYKNDQWQDKKLKktVSVLHFT
 . |    | .  |  |  .  |  ..|   .| . |.. | .....|      .. |   ..  .|... . .. . .   .    |..|  |.  |. 
lektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekark..vthyhwi

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGI-QLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
 ||| | |      |...  . . |  . ||||||.||||..| ..| . || . .   .   |.  .|. |  ..|. .| ... 
dwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh
subfamily_PTPN14_pd Subfamily PTPN14 940-1124 1e-16 55.8 In-house 100-289 (300) alignment 
Range on Protein: 940-1124
Range on HMM: 100-289/300.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEK--VGEKMTFGRYTVTTKSINTKLENFTDKksFVMYNLEykndqwqdKKLKKTVSVLH
 | . |....| .. . .| ....|.. .|.   |   |. ..    ....||.. ||||  ..     | .  . .. |          | ..||  | 
gPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittg..lklkhlp........skeertvwhlq

FTAWPDHGAPKNPDYALDIIRFCESYK-------------TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
.| ||||| |....  |. ..  .| .               ||||||||||||| |.     |.   .... .. ...  .|. |   ||.  |  .. 
ytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvY
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 928-1129 1.8e-16 55.0 In-house 22-219 (255) alignment 
Range on Protein: 928-1129
Range on HMM: 22-219/255.0
TEHLEKISKVPPKPKKS-TLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSintklenftDKKSFVMYNLEYKNdQWQD
|||..   ..  |   | |..| . .| | .   |. |.   | .  |   |.  .  ||. .   .|||                |.  ||    .  .
tehvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.........ssadvvlrtleits.tlge

KKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCESYkTSVLVHCSAGVGRTGTLVAIKYGIQ-----LCTTErTT--NLLSIVCPVRNCRFGAVQSAQQ
||  .||   ... |... ||...   | |..       ||.||||.|.||. ..| . .  |     | ||| |.  . ||..  .|. | .|..   |
kkkthtvkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldtte.tveldylslleelrskrkraihtPlq

LMYLIVCITK
| . |. . .
lafsilmvld
subfamily_PTPRN_pd Subfamily PTPRN 940-1132 1.8e-16 54.7 In-house 107-293 (297) alignment 
Range on Protein: 940-1132
Range on HMM: 107-293/297.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKmTFGRYTVTTKSINTKLENFTdKKSFVMYNLEYKNdqwqdkklKKTVSVLHFT
 |  ||. . | .. .  | .. .|... |.. .. . |. .. |.. ... | |   |     ...   .|| . ||. ..         .||. .|| 
gplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde.Gse.vyhiyevhlvsehiwcddyl.vrsfylknlqtse........trtvtqfhfl

AWPDHGAPKNPDYALDIIRFC-ESYK---TSVLVHCSAGVGRTGTLVAIKYGI-QLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVM
.||..|.| ..   |.  |    ||.   ....||||.|.||||. ..|   . .|    .  .. . .  .|. | | |.. .|. . . .... | 
swpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevn
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 940-1125 2.4e-16 54.2 In-house 88-264 (281) alignment 
Range on Protein: 940-1125
Range on HMM: 88-264/281.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTtksintkLENFTDKKSFVMYNLEYKNDQwqDkklKKTVSVLHFT
 ||| |    | .| | .   .  |. ..|..  | | |.  .    . | ...|.        |. | .||.|   |.   .   .    . ..   . 
gpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvs.......yedstvnkslvttrlnlsyeg..e...trlithwlwk

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTT-NLLSIVCPVRN-CRFGAVQSAQQLMYLI-V
 |||   |.  .  | |.|   .  |  ..||||||||.|||.|..  .|   .  |  ..  ||  .|   |  .||. || | .  |
ewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 940-1133 3.6e-16 53.6 In-house 95-238 (392) alignment 
Range on Protein: 940-1133
Range on HMM: 95-238/392.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDdrkfapyysekvgekmtfgrytvttksintklenftdkksfvmynleykndqwqDKKLKKTVSVLHFT
 |. ..|.  | .. | .|  .| .. . | |                                                        . ..||.  |||
gpnaaslddfwrmvfqenvttiamvtklkegd......................................................kgddartvaqfhft

AWPDHGAPKNPDYALDIIRFCE----SYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCITKGVMA
 |||.. ||     | .|.  .    .|   ...|||||||||| ...|   .  . . |  ... .|  .|. |   ||. .|  ..  .. . .. 
ewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllw
subfamily_CG7180_pd Subfamily CG7180 940-1133 4.3e-15 50.1 In-house 92-292 (296) alignment 
Range on Protein: 940-1133
Range on HMM: 92-292/296.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrKFAPYYSEKVgeKMTFGRYTVTTKSInTKLENFTDKKSFVMYN-LEYKNDQWQDKKLKKTVSVLHF
 |||.|....| .. . ..  |  |. . .    ..  |. .|   |  .|   | . .   .. |.. ..  .. . .   . . | |  ...| ....
apkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveivee.kqyanlkirtfkltkkivalteqekqvkaetRivklfql

TAWPD-HGAPKNPDYALDIIRFCESYKTSV---------LVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
| |.  .  |      ....|  ....  |         .|..| |..|.|  .||   ..|   |   ..   |  .|. | . |.. .. .|.   . 
teWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll

KGVMA
. |..
eavlc
subfamily_PTPN9_pd Subfamily PTPN9 941-1124 1.3e-14 48.9 In-house 93-283 (297) alignment 
Range on Protein: 941-1124
Range on HMM: 93-283/297.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTksINTKLENFTDKKSFVMYNLEykNDQwqdkklKKTVSVLHFTA
| | | . .| .. . .| ..   . |.|   .| . |. .. .. . || ..|..  .... |.   .......| .  ...      ...|.   |..
plkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsn..veveeeedykvrvleiknvk..tee......srkvthfqfls

WPDHGAPKNPDYALDIIRFCESYKT-----------------SVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
|||.| |..    ||...   ....                  ..||||||.|||||.... . ..   .. | ..   |  .|. |  ..|  .| .. 
WPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefc

I
 
y
subfamily_hpo-7_pd Subfamily hpo-7 940-1132 3.5e-14 47.3 In-house 37-228 (263) alignment 
Range on Protein: 940-1132
Range on HMM: 37-228/263.0
KPKKS----TLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTklenftdkkSFVMYNLEYKNDqWQDKKLKKTVSV
|   |    |..| .  | |     |. |.   | .  |   |.  .  ||. .   .|.|  .             ..  ||  .   ..||  .||  
knlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.........dvllktlellst.lgeKkkthtvkh

LHFTAWPDHGAPKNPDYALDIIRFCESYkTSVLVHCSAGVGRTGTLVAIKYGIQ----LCTTERTT--NLLSIVCPVRNCRFGAVQSAQQLMYLIVCITK
  .. |... .|...   | |..       |. ||||.|.||.   . .    |       |  |.  . ||..  .|. | .|..   || . |. . .
ysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd

GVM
 |.
fvl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 940-1123 5.1e-14 46.8 In-house 82-258 (283) alignment 
Range on Protein: 940-1123
Range on HMM: 82-258/283.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEkmTFGRYTVTTKSINTKlENFTDKKSFVMYNleykndqwqdKK-----LkktVS
 | . |    | .. . ..  .  |. . |  . | . |. ..  |   .| .||| .   |. . |. |.  . .|                 |   ..
sPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGse..dyGeftvtlrketts.nsfiikelllrvn..........ssakstll...la

VLHFTAWPDH--GAPKNPD--YALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
   .  | .   .|. |    . . |    || |. ..||||.|.|||....|.   ..   ||   .. ..|  .|. | .|||. .| . .
hyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 940-1124 5.7e-14 46.9 In-house 52-232 (237) alignment 
Range on Protein: 940-1124
Range on HMM: 52-232/237.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEkVGEKMTFGRYTVTTKsintKLENFTDKKSFVMyNLeykNDQWQDKKLKkTVSVLHFT
 | .|. .  | .. |    ..  |. .||... |   |. .   .  ..| .||. |    | |.|.|     .  |     ... |...  .   .||
gplesscddfwqmvwqekcsvivmltgliegnelkchkywps.tdqpaaygvltvslk....kkeefsdytvrsl.ll...skrltlkevr.lihqyqft

AWPDHGAPKNPDYAL----DIIRFCES--YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLI
.|||.| |..    |    .||   .     .  ..|||||||||| .. |   .. .  ..  ..   |  . . |   .|. .| ... 
swpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 941-1127 1.1e-12 42.4 In-house 88-273 (287) alignment 
Range on Protein: 941-1127
Range on HMM: 88-273/287.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKvGEKMTFGRYTVTTKSINTKLENFTdKKSFVMYNLEYKNdqwqdkklKKTVSVLHFTA
|  .|. . | .. .  .  |. ..  .|    |   |. |.    |  | |.|.  . . |  ...  ... . .|| ..         . |  |.. .
PiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeyg.vralrlidletre........arvvkqldlls

WPDHGAPKN----PDYALDIIRFCESYK-----TSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|||....        ..||. .. |  .       ..||...|.||.|.|.|.   ..        .   .|  .|. | . ||.. || .|.  .
wPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyeal
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 941-1123 1.4e-12 42.2 In-house 80-251 (267) alignment 
Range on Protein: 941-1123
Range on HMM: 80-251/267.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPyysEKVGEKMTFGRYTVTtKSintkLENFTDKKSFVMYNLEYKNDQWQDkklkktVSVLHFTA
| | |  ... || ...| ..  |  | . . |.| |    |.|.   .   ||  .|    ||.  .    .  .|..||.  ..      |.. ..  
plkntitdfltvihdqkvpvivlltkvftdnirlfwP...Pkmgqakkyqdltve.hs....lekeendyqiitlelkfknesahn......vtlyyykk

WPDHGAPK---NPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
|      |   .| ...      |     ..|.||.||||.||.. |.  ..   || ....   .  .|. | | |.. .. .|.
wnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1018-1161 2.5e-12 40.9 In-house 76-221 (440) alignment 
Range on Protein: 1018-1161
Range on HMM: 76-221/440.0
EYKNDQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCE-S----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFG
.| |  . .    .|.   |. .|||.| ||     | .|.  . |     .  .|||||||.|||| ..|.   .. .      ...|..  .|| |  
dyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpq

AVQSAQQLMYLIVCITKGVMAKEGVLYwrsFDAITYYHEQILADKYHDN
 ||. .|  ..  .. .|... . ..     | ||   |||   . | .
mvqtpeqyafvheavlegllcgdtlil...edditerveqiqwpnphtd
0038934 (Phosphotyrosine protein) phosphatases II 1007-1125 3.4e-12 41.9 In-house 53-171 (194) alignment 
Range on Protein: 1007-1125
Range on HMM: 53-171/194.0
TDKKSFVMYNLEYKNDQWQDKKLKKTVSVLHFTAWPDHGAPKNPDYALDIIRFCES-----YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTterttNLLS
  .| .  ..| . .  .  ....|     .   .||.|.. . .  |.......       .  |.||| ||.||||||||      |.      ..  
lnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.....saee

IVCPVRNCRFGAVQSAQQLMYLIV
 .  .| .| ||... ..| .| .
AialfrekRpgaipnqdyleallk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 949-1126 4.3e-12 40.7 In-house 67-235 (239) alignment 
Range on Protein: 949-1126
Range on HMM: 67-235/239.0
HWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGeKmtFGRYTVTTKsintKLENFTDK--KSFVMYNLEYKNDqwqdkklkKTVSVLHFTAWPDHGA
 | .. |    ..  |. .||   .|   |. .    |  .    || .    | | |.|   ..||| ..   ..        . |   ||| |||.| 
fwrmmwqerrcvivmltglieghkkkchqywpdsts.k..ycnlrvtlr....ktevfadyiirtfvmsqvgqtee........ryvyqyhftvwpdkgv

PKNPDYALDIIRFCE--SY--KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVC
|.     | . |     |       ..||||||||||... |   .. .  ..| ...  |  .|. |   ||...| ... ..
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 949-1125 5.1e-12 40.5 In-house 68-235 (239) alignment 
Range on Protein: 949-1125
Range on HMM: 68-235/239.0
HWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGeKmtFGRYTVTTKsintKLENFTDK--KSFVMYNLEYKNDqwqdkklkKTVSVLHFTAWPDHGA
 | .. |    ..  |. .||   .|   |. .    |  .    || .    | | |.|   ..||| ..   ..        . |   ||| |||.| 
fwrmmwqerrcvivmltglieghkkkchqywpdsts.k..ycnlrvtlr....ktevfadyiirtfvmsqvgqtee........ryvyqyhftvwpdkgv

PKNPDYALDIIRFCE--SY--KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIV
|.     | . |     |       ..||||||||||... |   .. .  ..| ...  |  .|. |   ||...| ... .
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 885-1059 2.4e-11 38.0 In-house 39-189 (297) alignment 
Range on Protein: 885-1059
Range on HMM: 39-189/297.0
HTLFLCEPKTMAKLVGFPD--PFINANVMKFG----EISWIMAQGPMdgtehlekiskvppkpkKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPY
..  |   .|  || . .    .|||. . |     .. .|.||||.                 ..|.. .| .. . ||.... .| . |    | |||
yrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGpl.................satvddfwtlvaeqdvrvivmvaklqedGrdkcapy

YSEKVGEKMTFGRYTVTTKSinTKLENFtDKKSFVMYNLEYKndqwqdkKLKKTVSVLHFTAWPDHGAPKNPDyalDIIRF
. . |.|... | . |   |  .  ..| |.  .   .| |.       . .. |    | .||||| | . .   |. ||
wpsvvqerlkagdvvvefls..stsdef.drviltelqliyr.......sesrvvrhvqflswpdhGvpsdle...dlvrf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 941-1123 3.3e-10 34.0 In-house 102-282 (310) alignment 
Range on Protein: 941-1123
Range on HMM: 102-282/310.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSeKVGEKMTFGRYTVTTKSINT-KLENFTDKKSFVMYNLEYKNDQWQDKKLKktVSVLHFT
| . |.   | .| |     .  |  | |    |   |.   .|   |.|   ||  |  . ..|      .||  |.   ..  . |.|.  ||.... 
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelr..vslikwp

AWPDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
 ||| | | .  ...    ...  .  ..||||||..|....||.|. |.        ..  ..  ... |.  .|.  | ...
nwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 940-1086 3.7e-10 34.1 In-house 111-284 (350) alignment 
Range on Protein: 940-1086
Range on HMM: 111-284/350.0
KPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFG---RYTVTTKSINTKLENFTDKKSFV-MYNL---EYKNDQWQDKKLKKT
 | .||... . || . .| ..  |.| .| . .|.  |. |   ...|     ..  ..   .. |  .  || ..   |    .  .|. .  ... .
aPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitla

V------SVLHFTAWPDHGAPKNPDYALDIIR---------FCESYK-----TSVLVHCSAGVGRTGTLVAIKY
.        |..  |.| .   ||   | ..          |.||.      ...|||||||||||||||.. .
asdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDs
subfamily_CG42327_pd Subfamily CG42327 1064-1123 8.6e-09 29.5 In-house 247-307 (319) alignment 
Range on Protein: 1064-1123
Range on HMM: 247-307/319.0
KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTE-RTTNLLSIVCPVRNCRFGAVQSAQQLMYL
.  . |||| ||||||...|    |.   .  |. ..  .|  ||. |  ||.. .|  ..
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 878-1127 9.4e-09 29.1 In-house 50-281 (302) alignment 
Range on Protein: 878-1127
Range on HMM: 50-281/302.0
ANISQRRHTLFLCEPKTMAKLVGFPDPFINANVMKFGEISWIMaqgpmdgtehleKISKVPPKPKKSTLEKHWAVIDQYDVGIVAQLASVIESDDrKFAP
.|... ... . .  ... || . || ..||  ..  |..  .             .. .| .  .. .|. | .. |  .  |  |.   | .   .  
knlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsi............ilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlse

YYSEKVGEKMTFGRYTVTTKsintKLENFTDKKsfVMYNLEYKNDQWQDKKLkktVSVLHFTAWPDHGAPKNPDYALDIIRFC----ESYKTSVLVHCSA
.. .| |.  ..|.  | ..    | |.  ..|   .| .|   .   .  |   ..| ..| |...  |..   .   .       .. . ....    
lfpkksgdykeygkmfvNnr....kVekaeeek..tryviEvlPegcsnsvl...anvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSkn

GVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCI
|.|| |....    ..  ...   |   ||  .|. |  ||.|..| . | ...
GaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 899-1094 1.5e-08 28.4 In-house 86-296 (349) alignment 
Range on Protein: 899-1094
Range on HMM: 86-296/349.0
VGFPDPFINANVMKFGEISWIMaqgpmdgtehlEKISKVPPKPkkSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYT--VTT
 | .| .|||| .|. .||                |..  | |  ||.. .. ||    | .|  | .  | . .|.  |. |   . .|         .
sgklddyinanylkltrisvek...........kyiatqaPlP..stvddfykvillngvklvlsLnddkelslekcdiywqelsysnitvklqnsslyi

KSINTK-LENFTDKKSFVMYNLEYKNDQWQDKKLKKTVS----------VLHFTAWPDHGAPKNPDYALDIIR---------FCESY-----KTSVLVHC
 ...   |. .|.|..    .   || . .|. .....            | .  |.| .   ||   |  .          |.. |      ...||||
anvqGnslrvstvkdtdndndnnkknCdlpddddddaillavekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhc

SAGVGRTGTLVAIKYGIQ-LCTTE
||| ||||.|| . . .. |  ..
saGcGrtGvlvtldlllsileplq
subfamily_CDC14_pd Subfamily CDC14 1054-1120 2.1e-08 28.4 In-house 253-314 (328) alignment 
Range on Protein: 1054-1120
Range on HMM: 253-314/328.0
LDIIRFCESYKTSVLVHCSAGVGRTGTLVAIkYgiqLCTTERTTNlLSIVCPVRNCRFGAVQSAQQL
   .. .|. . .. ||| ||.||||||.|  |   |  . | |    ..  .| || | | . || 
kkfleiaekaeGaiavhCkaGLGrtGtLiac.y...lmkhyrfta.aeaiawlricrPGsvigpqqk
PTEN_1 998-1083 2.4e-08 29.0 In-house 55-149 (196) alignment 
Range on Protein: 998-1083
Range on HMM: 55-149/196.0
SINTKLENFTDKKSFVMYNLEYKNDQ----WQDKK-LKKTVSVLHFtAWPDHGAPKnPDYALDIIRFCESY------KTSVLVHCSAGVGRTGTLVA
..   |.|.  .. .  .||. . .     .....  |. |..|||  ..|||||   .  .||.. ....      .  ||||| ||.||.||.||
dvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhf.pieDhgaps.lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_PTPDC1_pd Subfamily PTPDC1 1031-1121 5.9e-08 27.3 In-house 81-166 (182) alignment 
Range on Protein: 1031-1121
Range on HMM: 81-166/182.0
KTVSvLHFTAWPDHGAPkNPDYALDIIRFCESY--KTSVLVHCSAGVGRTGTLVAIkYgiqLCTTERTTNLlSIVCPVRNCRFGAVQSAQQLM
. .   .  .|.|.|..   . .|||..  ..   .  | ||| || |||| |.|  |   |  ..| |     .  ||. |  ..|. .|. 
qgiy.vynfgwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliac.y...lvyakrltae.kaiklvrskrpksiqtreqve
PTPc_motif_SM00404 1048-1083 6.7e-08 27.5 In-house 64-99 (140) alignment 
Range on Protein: 1048-1083
Range on HMM: 64-99/140.0
KNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVA
|  | .||.|. .|. ...||||| ||| |..||..
kyldkvldfienaekkggkvlVHCqaGvSRSatlii
DSPc Dual specificity phosphatase, catalytic domain 1042-1083 2.3e-07 25.8 Pfam-A 51-92 (133) alignment 
Range on Protein: 1042-1083
Range on HMM: 51-92/133.0
PDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVA
 .    |  . | ..|. .|. . .||||| ||. |..||..
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 1042-1083 2.3e-07 25.8 In-house 51-92 (133) alignment 
Range on Protein: 1042-1083
Range on HMM: 51-92/133.0
PDHGAPKNPDYALDIIRFCESYKTSVLVHCSAGVGRTGTLVA
 .    |  . | ..|. .|. . .||||| ||. |..||..
tetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1064-1128 3e-07 24.6 In-house 228-292 (297) alignment 
Range on Protein: 1064-1128
Range on HMM: 228-292/297.0
KTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYLIVCIT
.. .||||||||||.| .|  .  ..    .|  .  .|.  .|. |   ||. .|  .|   . 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_PTEN_pd Subfamily PTEN 999-1122 8.8e-07 24.1 In-house 50-171 (184) alignment 
Range on Protein: 999-1122
Range on HMM: 50-171/184.0
INTKLENFTdKKSFVMYNLEyKNDQWQDKKLKKTVSVLHFTawpDHGAPKNP---DYALDIIRFCESYKT-SVLVHCSAGVGRTGTLVAiKYGIQLCTTE
.   ||.   |... .|||   . ... ||... |.|. |.   || .|.     .   || .. |. |.  | ||| || ||||.|..  | .. ...|
vvkflekkh.kdhykiynlr.serkydskkfdgrvavypfd...DhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvliv.ayllksllle

RTTNLLSIVCPVRNCRFGAVQSAQQLMY
.... |..   .|     .|.   |. |
kaeealelfaeaRtknkkgvtiPsqrRY
0048567 (Phosphotyrosine protein) phosphatases II 1017-1084 9.2e-07 23.4 In-house 21-97 (157) alignment 
Range on Protein: 1017-1084
Range on HMM: 21-97/157.0
LEYKNDQWQDKKLKKTVSVLHFTAWPDHGaPKNP-------DYALDIIRFCESYKTSVLVHCSAGV---GRTGTLVAI
 .....  . . .  .  ..... . |.| | |         .. ......|  .  . |||.||    |||.||.. 
prlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigc
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1069-1123 1.8e-06 22.2 In-house 2-56 (69) alignment 
Range on Protein: 1069-1123
Range on HMM: 2-56/69.0
VHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLMYL
||||.| |||||..||   .    .|.  ...  |  .| ||   |    . |..
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 941-1120 2.4e-06 21.8 In-house 13-193 (199) alignment 
Range on Protein: 941-1120
Range on HMM: 13-193/199.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWQdKKLKKTVSVLHFTA
| . |.   | .. .   | .  .       .  .. |..        .|  .||||.| || .       ...  |   |.        . .|   ||.
plretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.......ytitaliltnntta.ppstreishyqfts

WPDHGAPKNPDYALDIIRFCES-------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTT--NLLSIVCPVRNCRFGAVQSAQQL
| .. .|.   .   ..   |          . |.|||| | | || .||.  |..     .|.  .|. .   .|..| | . | |. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1068-1121 2.4e-06 21.8 In-house 2-55 (69) alignment 
Range on Protein: 1068-1121
Range on HMM: 2-55/69.0
LVHCSAGVGRTGTLVAIKYGIQLCTTERTTNLLSIVCPVRNCRFGAVQSAQQLM
.||||.| |||||..||   .    .|.  ...  |  .| ||   |   .. .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 941-1120 2.7e-06 21.7 In-house 12-192 (198) alignment 
Range on Protein: 941-1120
Range on HMM: 12-192/198.0
PKKSTLEKHWAVIDQYDVGIVAQLASVIESDDRKFAPYYSEKVGEKMTFGRYTVTTKSINTKLEnftdkksFVMYNLEYKNDQWQdKKLKKTVSVLHFTA
| . ||   | .. .   | .  .       .  .. |..        .|  .||||.| || .       ...  |   |.        . .|   ||.
plretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpd.......ytitaliltnntta.ppstreishyqfts

WPDHGAPKNPDYALDIIRFCES-------YKTSVLVHCSAGVGRTGTLVAIKYGIQLCTTERTT--NLLSIVCPVRNCRFGAVQSAQQL
| .. .|.   .   ..   |          . |.|||| | | || .||.  |..     .|.  .|. .   .|..| | . | |. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy
subfamily_PRL_pd Subfamily PRL 1054-1123 3.5e-06 21.1 In-house 78-142 (151) alignment 
Range on Protein: 1054-1123
Range on HMM: 78-142/151.0
LDI--IRFCESYKTSVLVHCSAGVGRTGTLVAIKYgiqlctTERTTNLLSIVCPVRNCRFGAVQSaQQLMYL
|..   .|.|. |..| ||| ||.||.  |||.         |   .    |  .|. | ||. | .|| .|
lellkekfkeepkstvavhcvaGlGraPvlvalal......ieaGmkyedavefirekrrgains.kqlkfl