Gene F55H12.5 in Caenorhabditis elegans

Synonym: CELE_F55H12.5, F55H12.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf12
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP100_AA protein Get Run
CeleP100_AA_34-282 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 28-285 1.4e-29 99.0 In-house 7-293 (297) alignment 
Range on Protein: 28-285
Range on HMM: 7-293/297.0
KKKTTMLSPKKFCDFINSKTNSKSFEAGVAEFYKETYLESPTFFNYFKSPKDKNFSENVWLYDATRVIV-------PGVDYYHASWVDGLK--PNQYILA
....... | ...|... ... .|.    .||..   |  .. . ...  |||| . ... || .||..       .. ||..||.||| .  ....|..
allesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEFSSAITAKFEKGTGknD----FVSTAVIKE-NGLH-----------------LKAIKFCRWAEPLSAI
|.| .    .||.... . . . ..     .| .      .   .|       .| .  ... .| .                 .  ...     | |. 
qgPlpe.tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

EINDMLEKSRKYLGCP-LKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELCNRYK
 . ..||. |..|     .|| .. |..|  ..| .. ...  ..| |.|.    ...|..| .|.. . |.. |   .. |.||..|..
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0050432 (Phosphotyrosine protein) phosphatases II 26-284 1.8e-28 95.2 In-house 18-302 (308) alignment 
Range on Protein: 26-284
Range on HMM: 18-302/308.0
TRKKKTTMLSPKKFCDFINSKTNSKSFEAGVAEFYKETYlESPTFFNYFKSPKDKNFSENVWLYDATRVIVP-GVDYYHASWVDGL---KPNQYILAQAP
. ..... || .... ......... .|.   |... .    .... ...  |||| . ... || .||... | ||..||.|||    .|...|..|.|
silvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgP

RDAsAAKDFFKLLEHVKAEGLIVAEGADEFSS-------------------AITAKFEKGTGKNDFVSTAVIKEN-----GLHLKAIKFCRWAE---PLS
 .    .||.... . . .  ..    .| .                     .| .. . . ..|.. . .. .|      .... . .  | .   | |
lpn.tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps

AIEINDMLEKSRKYLgcpLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELCNRY
. .. |.||. ||.|    .|| |. |..|  ..| .. .|.  ..| |.|.    ...|..| .| . . |.. | . .  |.|.....
peilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0040438 (Phosphotyrosine protein) phosphatases II 51-284 6.5e-28 93.3 In-house 19-279 (317) alignment 
Range on Protein: 51-284
Range on HMM: 19-279/317.0
SFEAGVAEFYKETYLesPTFFNYFKSPKDKNFSENVWLYDATRVIVPG------VDYYHASWVDGLK-PNQYILAQAPRdASAAKDFFKLLEHVKAEGLI
 .. .  .... ..   .. . ...  |||| . ....||..||..         ||..||.||| . ....|..|.|   .   ||.... . . . ..
alleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.pntvedFwrmvweqgvtviv

VAEGADEFSS-------------------AITAKFEKgtgKNDFVSTAV-----IKENGLHLKAIKFCRWAE---PLSAIEINDMLEKSRKYLGcPLKGP
     .|..                      . ..|.   ..... . .      ... .... . .  | .   | |  .. |.||. |..|  . .||
mLteleelgrekcaqYwplgetltygdftvtllseee...lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggp

LVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELCNRY
... |..|  ..| .. ...  ..| |.|.   ....|..| .|.. . |.. |   .  |.|...|.
vlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0043336 (Phosphotyrosine protein) phosphatases II 47-270 2.8e-27 91.3 In-house 17-266 (278) alignment 
Range on Protein: 47-270
Range on HMM: 17-266/278.0
TNSKSFEAGVAEFYKETYleSPTFFNYFKSPKDKNFSENVWLYDATRVIVPG------VDYYHASWVDGLK-PNQYILAQAPRDAsAAKDFFKLLEHVKA
.. . ....  |... ..   .. . ...  |||| . ....|| .||..         ||..||.||| . |...|..|.| .    .||.... . . 
nlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.tvedFwrmvwelgv

EGLIVAEGADEFSS---------------AITAKFEKGTGKNDFVSTAVIKEN--------GLHLKAIKFCRWAEPLSAIEINDMLEKSRKYLGcPLKGP
. ...  . .|...                .| .. | . ..|.. .    .|        ..|.  ...     | |   . |.|.. |..|  . .||
ttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngp

LVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSY
... |..|  ..|... ...  ..|.|.|.    ...|..| .| . . |.. |
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqy
0046845 (Phosphotyrosine protein) phosphatases II 67-284 1.2e-26 89.2 In-house 18-277 (284) alignment 
Range on Protein: 67-284
Range on HMM: 18-277/284.0
SPTFFNYFKSPKDKNFSENVWLYDATRVIV-------PGVDYYHASWVDGL------KPNQYILAQAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEFSS
 .. . ...  ..|| . ... || .||..       .. ||..||.|||       .....|..|.| .    .||.... . ... ...  . .|.. 
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvweqnvrvIVmltelvengr

-----------------AITAKFEKGTGKNDFVSTAVI------KENGLHLKAIKFCRWAE---PLSAIEINDMLEKSRKYLGC-PLKGPLVIVCKDGAA
                  .| .. . . |.|.. . .       ... .... . .  | .   | |.  . ..|.. |..|   | .|| |. |..|  
ekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

KSGLVAFIDTEADRLMKHG---KAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELCNRY
..| .. .|.  ..| |.|   .    ...|..| .| . . |.. | . .. |.|.....
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0051299 (Phosphotyrosine protein) phosphatases II 32-277 1.7e-26 88.8 In-house 3-282 (288) alignment 
Range on Protein: 32-277
Range on HMM: 3-282/288.0
TMLSPKKFCDFINSKTnsKSFEAGVAEFYKETYLES---PTFFNYFKSPKDKNFSENVWLYDATRVIV------PGVDYYHASWVDG-LKPNQYILAQAP
| .| ........ ..  ... .|..| ..| .      .. . ...  ..|| . ... || .||..      .| ||..||..||  .....|..|.|
teisveellklvlkll..angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgP

RDAsAAKDFFKLLEHVKAEGLIVAEGADEFSS----------------AITAKFEKGTGKNDFVSTAV---------IKENGLHLKAIKFCRWAE---PL
 .    .||.... . . .  ..  . .|..                  || .. . . ..|.. . .          ... .. . . .  | .   | 
lpn.tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd

SAIEINDMLEKSRKYLGcPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSL
|. .. |.|.. ||.|  . .|| |. |..|  ..| .. .|.  ..| |.|.    ...|..| .| . . |.. | . .  |
spellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
0042113 (Phosphotyrosine protein) phosphatases II 73-275 5.1e-25 83.7 In-house 5-237 (245) alignment 
Range on Protein: 73-275
Range on HMM: 5-237/245.0
YFKSPKDKNFSENVWLYDATRVIVP------GVDYYHASWVDGLK-PNQYILAQAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEFSSA-----------
...  |||| ......|| |||...      ..||..||.||| . ....|..|.| .    .||...| . . . ..     .|..             
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvkcaqywplges

-----ITAKFEKGTGKNDFVSTAVIKE--------NGLHLKAIKFCRWAEPLSAIEINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRL
     .| .. . . ..|.. . .  .        ...|.  . .    .| .   . |.||  ||.|  . .||... |..|   .|... ... ...|
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

MKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGIN
 |...    ...|..| .|.. . |.. |   . 
ekelgvsleeavkelrsqRpgavqtpsqyrflye
0045450 (Phosphotyrosine protein) phosphatases II 53-272 7.3e-25 83.8 In-house 26-295 (307) alignment 
Range on Protein: 53-272
Range on HMM: 26-295/307.0
EAGVAEFYKeTYL------ESPTFFNYFKSPKDKNFSENVWLYDATRVIV-------PGVDYYHASWV--------DGL-KPNQYILAQAPRDAsAAKDF
 .|... .. . |        .. . ...  |||| . ....|| |||..       .. ||..||.|        ||  .....|..|.| .    .||
ltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.tvedF

FKLLEHVKAEGLIVAEGADEFSSAITAKF-----------------EKGTGKNDFVSTAV------IKENGLHLKAIKFCRWA---EPLSAIEINDMLEK
...| . . . ..   . .|. . . |..                  . . ..... . .       ........ . . .|     | |  |. |..|.
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

SRKYLG-CPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGK---AKHTDTIKQIRFMRSNTFDTFDSYDL
 ||.|. .| .|| .. |..|   .| .. ...  ..| |.|.       ...|..| .|.. . ... |  
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf
0047943 (Phosphotyrosine protein) phosphatases II 62-274 2.2e-24 81.8 In-house 23-265 (273) alignment 
Range on Protein: 62-274
Range on HMM: 23-265/273.0
ETYLESPTFFNYFKSPKDKNFSENVWLYDATRVIV--PGVDYYHASWVDG-LKPNQYILAQAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEFSS-----
... . .. . ...  |||| . ... || .||..  .| ||..||.|||  .....|..|.| .    .||.... . ... ...    .| .      
slkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn.tvedfwrmvweqnvrviVmLtelvelgrekcaq

--------------AITAKFEKGTGKNDFVSTAVIKEN-----GLHLKAIKFC---RWAEPLSAIEINDMLEKSRKYLG-CPLKGPLVIVCKDGAAKSGL
               .| .. . . |.|.. . .. .|      .. . . .        | |  .. ...|. ||.|  .| .|| |. |..|  ..| 
YwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgt

VAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGI
.. .|.  |.| |.|.    ...|..| .| . . |.. | . .
fialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0040439 (Phosphotyrosine protein) phosphatases II 69-279 2.2e-24 81.9 In-house 3-244 (249) alignment 
Range on Protein: 69-279
Range on HMM: 3-244/249.0
TFFNYFKSPKDKNFSENVWLYDATRVIV------PGVDYYHASWVDGLK-PNQYILAQAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEF----------
. . ...  |||| . ... || .||..      .. ||..||..|| . ....|..|.| .  . .||...| . . . .. .   .|.          
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqywp

------SSAITAKFEKGTGKNDFVSTAV-----IKENGLHLKAIKFCRWA---EPLSAIEINDMLEKSRKYLGCP-LKGPLVIVCKDGAAKSGLVAFIDT
         .| .. . . |.|.. . .      . . .. . | .  |     | |  .. |..|. ||.|     .||... |..|  ..|... ...
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

EADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE
  ..| |...    ...|..| .|.. . ... |   .. |.|
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 64-281 8.6e-22 73.2 In-house 26-277 (297) alignment 
Range on Protein: 64-281
Range on HMM: 26-277/297.0
YLESPTFFNYFKSPKDKNFSENVWLYDATRVIVPGV--DYYHASWVDGLK-PNQYILAQAPRDAsAAKDFFKLLEHVKAEGLIVAEGADEF---------
.|  ..    ..  ..|| . ... || |||....   ||..||.||| . ....|..|.| .     ||.... . . . ...    .|          
lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn.tvedFWrmvweqnvtvIvmltelvelgrekcaqyw

SSA---------ITAKFEKGTG--KNDFVSTAVIKEN----------GLHLKAIKFCRWAE-PLSAIEINDMLEKSRKYLGCPlkGPLVIVCKDGAAKSG
..          .| .. . .   ..|.. . .  ..           .| . .      | | | ... ....| .|.|  .  || .. |..|  .||
pleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg..gpvlVHCsaGvgRsg

LVAFIDTEADRLM---KHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELC
 .. .|.  ..|    |.|.    ...|..| .| . . |.. |   .  |.||.
tfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 58-281 7e-20 67.0 In-house 14-272 (278) alignment 
Range on Protein: 58-281
Range on HMM: 14-272/278.0
EFYKETYLESPTFFNYFKSPKDKNFSENVWLYDATRVIvpgvDYYHASWVDGLkPNQYILAQAPRDaSAAKDFFKLLEHVKAEGLIVAEGADEFS-----
||   ..  |  ... . ...|||   ... || .||.    || .||..||  |...|..|.| . | . ||...| . . . .. . .  | .     
efllllgipseitpalylgnldknRykdilpydhsrVk....dYINAsyidgy.pkkfIatqgPlp.stvadfwrmlwelgitvivmltelvelgrekca

-----------SAITAKFEKGTGKNDFVSTAVIKENG---------LHLKAIKFCRWA---EPLSA--IEINDMLEKSRKYLG------------CPLKG
             .| .... .  .|.. .  . .|          .... ...  |     | .     . ..||  |..|              . .|
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PLVIVCKDGAAKSGLVAFIDTEADRLmkHGKAKHTDTIKQIRFMRSN-TFDTFDSYDLGINSLIELC
| .. |. |   .| .. ...  ..|  .|.    ...|..| .| .  . ... |   .  |.|| 
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0049772 (Phosphotyrosine protein) phosphatases II 71-283 2.2e-17 59.2 In-house 41-282 (314) alignment 
Range on Protein: 71-283
Range on HMM: 41-282/314.0
FNYFKSpKDKNFSENVWLYDaTRVIVP-----GVDYYHASWVDGLkpNQYILAQAPRDASAAKD------------------------------------
...|.  .||| . ... .| .|||.|     |.||..||.|||   ...| .|.|..                                          
adlfln.rdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------FFKLLEHVkaeGLIVAEGADEFSsaitakfEKGTGKNDFvstaviKENGLHLKAIKFCRWAEPlSAIEINDMLEKSRKYlgcPLKGPLV
           . .| ..    .. .|.  ...        |  . ...|      ...|.... | .  . .| .   ....||  ...   . .||..
srLdaAlgKtpllildgng...neptaadlellk.......eelydpelf......erlgikylripvpDgsap.lledfdeflefieea...dkggpvl

IVCKDGAAKSG-LVAfidteADRLMKHGKAKHTDTIKQIRFMRS-----NTFDTFDSYDLGINSLIELCNR
. ||.|   .| .|.     |. |||. .    ......| .|.     ... ... |    . | |....
vHCkaGkgRtgtfvv.....aaylmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkf
DSPc_SM00195 66-279 4.7e-17 57.5 In-house 15-260 (263) alignment 
Range on Protein: 66-279
Range on HMM: 15-260/263.0
ESPTFFNYFKSPKDKNFSENVWLYDATRVIVPGV------DYYHASWVDGL-KPNQYILAQAPRdASAAKDFFKLLEHVKAEGLIVAEGADE--------
...|  . .|. |.|| ..|. .|| |||...        ||..|....|  |...||..|.|   |  .||...  . | .  ..    .|        
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeengkekcdr

-FSSAI---------TAKFEKGTGKN-DFVS-TAVIKENG----LHLKAIKFCRWAEPLSA---IEINDMLEKSRKYLGCPlKGPLVIVCKDGAAKSGLV
 . . .         . |. . . |. ...  |  ....|      .. ...  | .        .. ..|.. .|      .||.|..|..|  ..| .
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtf

AFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE
. ||.  ..| .. | .  ...|..|  | . ..|.. |   .. ..|
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 66-279 4.7e-17 57.5 In-house 15-260 (263) alignment 
Range on Protein: 66-279
Range on HMM: 15-260/263.0
ESPTFFNYFKSPKDKNFSENVWLYDATRVIVPGV------DYYHASWVDGL-KPNQYILAQAPRdASAAKDFFKLLEHVKAEGLIVAEGADE--------
...|  . .|. |.|| ..|. .|| |||...        ||..|....|  |...||..|.|   |  .||...  . | .  ..    .|        
pketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeengkekcdr

-FSSAI---------TAKFEKGTGKN-DFVS-TAVIKENG----LHLKAIKFCRWAEPLSA---IEINDMLEKSRKYLGCPlKGPLVIVCKDGAAKSGLV
 . . .         . |. . . |. ...  |  ....|      .. ...  | .        .. ..|.. .|      .||.|..|..|  ..| .
ywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtf

AFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE
. ||.  ..| .. | .  ...|..|  | . ..|.. |   .. ..|
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0037934 (Phosphotyrosine protein) phosphatases II 73-269 9.2e-17 56.9 In-house 6-230 (243) alignment 
Range on Protein: 73-269
Range on HMM: 6-230/243.0
YFKSPKDKNFSENVWLYDATRVIVPGVDYYHASWVDGLkPnQYILAQAPRDAsAAKD----FFKLLEHVKAEGLIVAEGADEFSSAITAKF---------
 ..  ..||   ....|| .||...| ||..|...... | ..|. |.| .    .|    |...| . . . ..     .| .    |..         
llpenlsknrysdilpydhsrvklegsdyinanliyvt.p.rliatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygd

-----EKGTGKNDFVS---------TAVIKENGLHLKAIKFCRWAEPLSAIEINDMLEKSRKYLGC-------PLKGPLVIVCKDGAAKSGLVAFIDTEA
      . . ..|..          .   . .. |.  . .     | |   . |.|.. |...         . .||... |. |  ..|... ...  
ftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylml

DRLmkhgKAKHTDTIKQIRFMRSN-TFDTFDS
..|    .    ...|..| .|..  . |.. 
lll....gvdleeavkllreqRpgkavqtpsq
0041856 (Phosphotyrosine protein) phosphatases II 78-272 4.5e-13 44.6 In-house 2-162 (182) alignment 
Range on Protein: 78-272
Range on HMM: 2-162/182.0
KDKNFSENVWLYDATRvivpGVDYYHASWVDGLKPN-QYILAQAPRDASAAKDFFKLLEHvKAEGLIVAEGADEFSSAItakfekgtgkndfvstaviKE
.|||  .... || .|    . || .|....|  |. ..|..|.| . . |...  | |. .   .. . .   . .                     . 
ldknrysdilpydhsr....dldyInanlylgslpatrfiatqgpllstvadflrmlkel.gittivnlteelywpell...................er

NGLHLKAIKFCRWAEPLsAIEINDMLEKSRKylgcpLKGPLVIVCKDGAAKSGLVAFIDteadrLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDL
.|.... . .  .  |    |..|..|. ..      .|| .. |. |  ..| .. ..     |||. .   ....|..| .|.. . | . | .
lgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaay.....lmkklgvsleeavklvrsrRpgmvitpnqyff
PTPc_DSPc_SM00012 196-277 2.4e-12 42.3 In-house 20-103 (105) alignment 
Range on Protein: 196-277
Range on HMM: 20-103/105.0
IEINDMLEKSRKYLGCPL-KGPLVIVCKDGAAKSGLVAFIDTEADRLMKH-GKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSL
 .| ..|.. .|       ..|.|..|..|. ..| .. .|.  ..|.|. .. .  ...|..| .|.....|.. |   .. |
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyral
Y_phosphatase Protein-tyrosine phosphatase 78-140 9e-11 37.0 Pfam-A 2-68 (235) alignment 
Range on Protein: 78-140
Range on HMM: 2-68/235.0
KDKNFSENVWLYDATRVIV---PG-VDYYHASWVDGLK-PNQYILAQAPRDaSAAKDFFKLLEHVKAE
|.|| ....  || ||| .   .|  ||..|..|.| | ....|..|.| . |  .||.... . | .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvk
Y_phosphatase Protein-tyrosine phosphatase 78-140 9e-11 37.0 In-house 2-68 (235) alignment 
Range on Protein: 78-140
Range on HMM: 2-68/235.0
KDKNFSENVWLYDATRVIV---PG-VDYYHASWVDGLK-PNQYILAQAPRDaSAAKDFFKLLEHVKAE
|.|| ....  || ||| .   .|  ||..|..|.| | ....|..|.| . |  .||.... . | .
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvk
Y_phosphatase Protein-tyrosine phosphatase 192-272 1.2e-08 30.1 Pfam-A 149-228 (235) alignment 
Range on Protein: 192-272
Range on HMM: 149-228/235.0
PLSAIEINDMLEKSRKYLgCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDL
| |. .. |...| .|.   . .||.|..|..|. ..| .. .|.  ..| .... .  ...|..|  | . ..... |  
pespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYif
Y_phosphatase Protein-tyrosine phosphatase 192-272 1.2e-08 30.1 In-house 149-228 (235) alignment 
Range on Protein: 192-272
Range on HMM: 149-228/235.0
PLSAIEINDMLEKSRKYLgCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDL
| |. .. |...| .|.   . .||.|..|..|. ..| .. .|.  ..| .... .  ...|..|  | . ..... |  
pespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYif
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 73-279 2.4e-08 28.9 In-house 21-253 (284) alignment 
Range on Protein: 73-279
Range on HMM: 21-253/284.0
YFKSPKDKNFSENVWLYDATRVIV------PGVDYYHASWVDGL-KPNQYILAQAPRDASaAKDFFKLLEHVKAEGLIV---AEGADEFSSAITAKFEKG
  .  ||||   ..  .| ..| .       . ||  ||.. |  ....|| .| |.| .  .||....   ..  ...      .. .   |  | |..
nldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldnt.ladfWrmiweyncstivlltkdkcsqywplkivikeerf

TGKNDFVSTA---V-----IKEN-----GLHLKAIKFCRWAE---PLSAIEINDMLEKSRK-YLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHG
  | | |. .   |     . |.       ...  .|  | .   | .....  ...| |.       . ..|. |  |. ..|    .|.  ||. .  
kvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeek

KAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE
.    ......|  |..  . .  | .   .|.|
qvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 71-279 2.9e-08 28.4 In-house 55-289 (319) alignment 
Range on Protein: 71-279
Range on HMM: 55-289/319.0
FNYFKSPKDKNFSENVWLYDATRVIV------PGVDYYHASWVDGL-KPNQYILAQAPRDASaAKDFFKLLEHVKAEGLIV---AEGADEFSSAITAKFE
|   .  ||||   |.  .| ..| .       . ||  ||.|.|  ....|| || |.| .  .||....   ..  ...      .. .   |  | |
fanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldnt.ladfWrmiweyncstivlltkdkcsqywplkivikee

KGTGKNDFVSTA---VI-----KENG-----LHLKAIKFCRWAE---PLSAIEINDMLEKSRK-YLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMK
..  | | |  .   |.      |.|      ...  .|  | .   | .....  ...| |.       . ..|. |  |. ..|    .|.  ||. .
rfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmke

HGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIE
  .    ......|  |..  . .  | .   .|.|
ekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0036282 (Phosphotyrosine protein) phosphatases II 100-267 1.1e-07 27.2 In-house 3-156 (174) alignment 
Range on Protein: 100-267
Range on HMM: 3-156/174.0
DYYHASWVDGLK-PNQYILAQAPRDasaakdFFKLLEHVKAEGLIVAEGADEFS---------SaitakfekgtgkndfvSTAVIKENGLHLKAIKFCRW
||..||..|.   .. .|. |.| .      |...| . . . ..      |           .                     ...|.... . .   
dyinaspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe................lredlerlgiqylylpwpDh

AEPLSAIeINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMkHGKAKHTDTIKQIRFMRSNTFDTF
 .| ..| . ....  ...|  . .||... |. |   .|... ..    .|. ..  .  |.....|..|.. . |.
gvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp
subfamily_PTPRD_pd Subfamily PTPRD 78-134 2.6e-07 24.7 In-house 49-111 (564) alignment 
Range on Protein: 78-134
Range on HMM: 49-111/564.0
KDKNFSENVWLYDATRVIV------PGVDYYHASWVDGL-KPNQYILAQAPRdASAAKDFFKLL
| ||  .|.  ||..||.       .| ||  ||..||  |...|| .|.|  |.. .|| ...
kaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl.aetiedFWRmv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 75-140 3e-07 24.9 In-house 39-110 (281) alignment 
Range on Protein: 75-140
Range on HMM: 39-110/281.0
KSPKDKNFSENVWLYDATRVIV------PGVDYYHASWVDG-LKPNQYILAQAPRDASAaKDFFKLLEHVKAE
.  . ||   |.  |||||| |         ||  |..|.|  ....|| .|.|  ||  ..|....   |..
denvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPasl.vafWqmvweqkvs
subfamily_PTPN9_pd Subfamily PTPN9 209-283 4.2e-07 24.3 In-house 218-292 (297) alignment 
Range on Protein: 209-283
Range on HMM: 218-292/297.0
LGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELCNR
 | | . |.|. |  |  ..|  . .|   .|| . |... ..|.|..|  |. .  | . | .   ...|   .
kghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_CG7180_pd Subfamily CG7180 184-271 4.8e-07 23.7 In-house 185-280 (296) alignment 
Range on Protein: 184-271
Range on HMM: 185-280/296.0
IKFCRWAE----PLS---AIEINDMLEKSRKYL-GCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYD
...  |      |||    ||.  . .. |.     | .||.|.|..|||..||    ||   . . |...    . .|..|  | .  .. . | 
fqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 72-143 5e-07 24.0 In-house 42-115 (287) alignment 
Range on Protein: 72-143
Range on HMM: 42-115/287.0
NYFKSPKDKNFSENVWLYDATRVIVPGV--DYYHASWVDGLKP-NQYILAQAPRdASAAKDFFKLLEHVKAEGLI
|  .. |||| ....  .|  ||.. |   ||  |...|| |  ...|.|..|  ...|..|.||... . . ..
niasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPm.fntarnfWkliddrnvtaiv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 76-144 5.9e-07 23.8 In-house 47-121 (319) alignment 
Range on Protein: 76-144
Range on HMM: 47-121/319.0
SPKDKNFSENVWLYDATRVIVP------GVDYYHASWVDGLKP-NQYILAQAPRDAsAAKDFFKLLEHVKAEGLIV
  |.||  .|.  || |||...      | ||  ||..|| .  ...| .||| .  . .||.... . ..  ...
enkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen.tiedfWrmvWeeessivvm
subfamily_PTPRK_pd Subfamily PTPRK 179-281 7.6e-07 23.2 In-house 173-277 (314) alignment 
Range on Protein: 179-281
Range on HMM: 173-277/314.0
LHLKAIKFCRWAE---PLSAIEINDMLEKSRKyLGCPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGIN
  .. ..| .|..   | ||  . ... .  |    . .|..|. |  || ..|    ||.  | . ..|      ..|..|  ..|  .| . | .  .
revrqfqflgWpdhdvPvsatgllklvrrvkk.sqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiyd

SLIELC
 ..| |
vileac
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 46-139 9.4e-07 22.8 In-house 27-119 (290) alignment 
Range on Protein: 46-139
Range on HMM: 27-119/290.0
KTNSKSFEAGVAEFYKETYLESPTFFNYfkSPKDKNFSENVWLYDATRVIVP---GVDYYHASWVDGLKPnQYILAQAPRDASaAKDFFKLLEHVKA
.  .| .   .  .    |||   | .   .   ||   .|   | ||||.      || || .|.|||.  .||.| .  .. . |..... . |.
delakeyleklkpylpvqylerkifdkn..tefkknrykdvvcndktrvilkdGydGdyvhanyvkGlka.mfiltqGalkdt.vidiwrmvlqekv
0051082 (Phosphotyrosine protein) phosphatases II 98-267 1e-06 24.0 In-house 2-139 (151) alignment 
Range on Protein: 98-267
Range on HMM: 2-139/151.0
GVDYYHASWVDGLkpnqYILAQAPRDasaakDFFKLLEHVKAEGLIVAEGADEFSsaITAKFEKGTGkndfvstavikengLHLKAIKFCRWAEPLSAIE
 .||...|.|.|     ... ..| .     ||..||.. .    .   . .|      ... . .|              .... | .  | .|   . 
lsdyinfsyvtgg....lyrsggpla.....dflellkelgiktivnlrseeerg..ycpeylpelg..............ievlhipildwpdpglpls

INDMLEKSRKYLGcPLKGPLVIVCKDGAAKSGLVAFIDteadrLMKHGkAKHTDTIKQIRFMRSNTFDTF
.. .||  ...|  . .||... |. |   .|... ..     ||..|     ......| .| . . ..
fdavleflellld.kkngpvlvHCsaGkgRTGtlvaly.....lmllg.vsleealeeyrlkrpgvvqpn
DDE_Tnp_IS240 DDE domain 85-167 1.1e-06 16.1 Pfam-A 2-85 (140) alignment 
Range on Protein: 85-167
Range on HMM: 2-85/140.0
NVWLYDATRVIVPGVDYYHASWVDGLKPNQYILAQAPRDASAAKDFFK-LLEHV-KAEGLIVAEGADEFSSAITAKFEKGtGKND
..|  | | | | |  .|    ||  .    .| .. ||| ||| |.. .|..  ...  ||....  ...|..  .|.|  ...
kswrvDEtyvkvkGkwaYlyravDkegrildfllskrRdakaakaflrkalkklkeeprkivtDklsayaaalkelkeeg.klle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 75-269 1.4e-06 22.0 In-house 43-224 (392) alignment 
Range on Protein: 75-269
Range on HMM: 43-224/392.0
KSPKDKNFSENVWLYDATRVIV------PGVDYYHASWVDGLKP-NQYILAQAPRDASaAKDFFKLLEHVKAEGLIVAEGADEFSsaitakfekgtgknd
.  . ||  .|.  ||..||..      |  ||. ||......  . || .|.|  ||  .||.... . ..  ... .  .|                 
einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaas.lddfwrmvfqenvttiamvtklkegd...............

fvstavikeNGLHLKA---IKFCRWAEPL---SAIEINDMLEKSRKYLGcPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRS
         .| . ..    .|  | .      .  .  .... .   |     ||.| |  | ...|.|  ||.   .  |       . . .||  | 
.........kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG.qythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp

NTFDTFDS
   .| . 
ymvqtkeq
0044763 (Phosphotyrosine protein) phosphatases II 95-267 1.4e-06 23.6 In-house 14-157 (178) alignment 
Range on Protein: 95-267
Range on HMM: 14-157/178.0
IVPGVDYYHASWVDglkPNQYILAQAPrdasaaKDFFKLLEHVKAEGLIVAEGADEFSS---AITAK---FekgtgkndfvstavikengLHLKAIKFCR
 ....||..||...   |. |. .. |       |...||   .   ..   . .|         .                        .. . | .  
glersdyinaseil...pglylgslpp......addlellkelgithivnlteelelgflkcdpywpeeag...................iqylhipipD

WAEPLSAIEINDMLEKSRKYLGcPLKGPLVIVCKDGAAKSGLVAFIDteadrLMKHGKAKHTDTIKQIRFMRSnTFDTF
. .| .   . ...|  ...|  . .|| .. |. |   ||... ..     |||. .    . |...| .|.  . ..
hgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaay.....lmkklglsleeaielvrerRp.ivpnp
subfamily_Ptp69D_pd Subfamily Ptp69D 77-158 1.6e-06 22.4 In-house 48-135 (307) alignment 
Range on Protein: 77-158
Range on HMM: 48-135/307.0
PKDKNFSENVWLYDATRVIVPGV------DYYHASWVDGL-KPNQYILAQAPRDaSAAKDFFKLLEHVKAEGLIVAEGADEFSSAITAK
 . || .|..  .| |||... .      ||  ||.. |  . ...| ||.| . . ..||....   . . ...    .| . .  ||
nalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve.atigDfWRmiaeqevtlivmlsnlteknrkkcak
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 151-277 1.8e-06 21.9 In-house 155-283 (305) alignment 
Range on Protein: 151-277
Range on HMM: 155-283/305.0
FSSAITAKFEKGTGKNDFVSTAVIKENGLHLKAIKFCRWAE------PLSAIEINDMLEKSRkylgcPLKGPLVIVCKDGAAKSGLVAFIDTEADRLMKH
| |. | ||.| .  .   .  ||.  | . . ..   | .      | . . | ..|||.|     |.|||.|. |  |  ..| | ...   |.|.  
fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar.....pskgpivvhcsagigrtgsvvmleyildqllag

GKAKHTDTI-KQIRFMRSNTFDTFDSYDLGINSL
 . ..|| | ..||  | |. .| . | .  . .
qiiedtdkilqkireqrnnsiqtdaqylfvhqvi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 42-143 3.2e-06 21.5 In-house 12-118 (305) alignment 
Range on Protein: 42-143
Range on HMM: 12-118/305.0
FI--NSKTNSKSFEAGVAEFYKEtylESPTFFNYFKSPKDKNFSENVWLYDATRVIVP---G---VDYYHASWVDGLK-PNQYILAQAPRDaSAAKDFFK
.|  ......|..||   ..|.|   |.... .  .  | || .... |.|  |.|.         ||  ||.||| |  ..||.||.| . .  .||..
yikearvysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk.ntvadfWr

LLEHVKAEGLI
|. ..| . ..
liveekvstiv
0043147 (Phosphotyrosine protein) phosphatases II 98-268 3.2e-06 22.5 In-house 4-148 (172) alignment 
Range on Protein: 98-268
Range on HMM: 4-148/172.0
GVDYYHASWVDGLKP-NQYILAQAPrDASAAKDFFKLLEHVKAEGLIVAEGAdefssaitakfekgtgkndFVSTAVIKENGLHLKAIKFCRWAEPlSAI
| ||..||..|.    ...|  |.|   .   ||...| . .   .. . .                    .. .   ...|...  . .     | .. 
gsdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltel...................lydpellerlgiqylylpwpDhgvp.lle

EINDMLEKSRKYLGCPLKGPLVIVCKDGAAKSGLVAFIDTEAdrlmkhGKAKHTDTIKQIRFMRSNTFDTFD
 . ..||  ...|    .|| .. |. |   .|... ..          . .  ......| .|.. . ...
llleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 68-150 3.4e-06 20.7 In-house 25-112 (332) alignment 
Range on Protein: 68-150
Range on HMM: 25-112/332.0
PTFFNYFKSPKDKNFSENVWLYDATRVIVPG----VDYYHASWVDGL-KPNQYILAQAPRDASAAKDFFKLLEHVKAEGLIVAEGADE
|  .. |    | |    .. .| .|| .       |.| ||||||  | . ||.|||| .  .   |....   |   ..|    ||
pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdide
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 198-286 6.7e-06 20.3 In-house 180-269 (270) alignment 
Range on Protein: 198-286
Range on HMM: 180-269/270.0
INDMLEKSRKYLGCPLKG-PLVIVCKDGAAKSGLVAFIDTEADRLMKHGKAKHTDTIKQIRFMRSNTFDTFDSYDLGINSLIELCNRYKK
.  ||.. |..     |. ||.. | .|  ..|..  .|.    | ...|.  .  |...|  | .  .. . | .  ....| ..| .|
llkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 72-164 6.9e-06 19.7 In-house 46-143 (302) alignment 
Range on Protein: 72-164
Range on HMM: 46-143/302.0
NYFKSPKDKNFSENVWLYDATRVIVP--GVDYYHASWVDG--LKpNQYILAQAPRDASA--AKDFFKLLEHVKAEGLIVAEGADEFSSAITAKFEKGTG
. ||.  .|| ||.| ..|...|...    .|..|| |.   |. .. |||| |   |.    .| ..  . |   . .. | .| . ..   | | .|
kafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksg
subfamily_PTPN23_pd Subfamily PTPN23 78-140 8.6e-06 19.8 In-house 44-109 (288) alignment 
Range on Protein: 78-140
Range on HMM: 44-109/288.0
KDKNFSENVWLYDATRVIVPGV--DYYHASWVDGLKPN--QYILAQAPRDASaAKDFFKLLEHVKAE
 .|| |...  || .|| . |   ||  ||.| .| |   ..| .|||.. . . ||.... . |..
seknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst.lnDFWlmvyeqkss