Gene H06I04.5 in Caenorhabditis elegans

Synonym: CELE_H06I04.5, H06I04.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP109_AA protein Get Run
CeleP109_AA_761-1050 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 764-1063 1.1e-170 560.8 In-house 1-302 (302) alignment 
Range on Protein: 764-1063
Range on HMM: 1-302/302.0
IQYQMKENKTLLQEWLKSVYRALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFGKIEWIMAQGPMDGTEKKKDETDK---PK
|....|.|||||.|.|..|.|||........||....|||||.|..||||.|||.|..|||.||||||.....|.||||||||||||||.....|   ||
igadrklnktlleefleyveraleklkkktstnlekdiserrkslficepktmaklvdfkndfinanvlkldeikwimaqGpmdGtekkekvskkpivpk

RSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLAEFTDKKDFTLYTVEITNYRKNKgEQKKTVDILLYSAWP
.||.|||||||||.||||.||||.|||.|.||||.||||||||.|.|..|..||...||||.||||||.|.||||||.|..|.| ..|||||||..||||
kstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdilafsawp

EHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKMPVPYLRS
.||||.|||.||.||||||.||||||||||.|||||||||||||||.||.|||||....|.|||||||.|||||..|..|.|||||||||||..|.||||
dhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglmekagvlylrs

FDA
|||
fda
0036941 (Phosphotyrosine protein) phosphatases II 773-1060 3.3e-56 186.1 In-house 13-288 (297) alignment 
Range on Protein: 773-1060
Range on HMM: 13-288/297.0
TLLQEWLKSVYRALRtIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFGK--IEWIMAQGPMDgtekkkdetdkpkrSTCEKHWAL
.||... ..... |  .|..||... .|..  |.. ... ..|. .|.. .. .|||. . . .   ..|..|||..              .|.|..| .
alllkefeellplll.lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlp..............ntvedFWrm

IEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDlaeftDKKDFTLYTVEITNYrknKGEQKKTVDILLYSAWPEHGAPQEAYP
. ..|| . | |. .|| . .|||.|.....|..| . ............     ...|.||.|.|.|..   ......|| .. |  ||.||.|. ...
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt...gngesrtvthfhytgwpdhgvpespas

ALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCL---KKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKMPVPYLRS
 |........       .. |||||| ||||.||..|. . ...     | .   | .... .|..|.||||   |  ..  .. . |. |.....|..
lldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllk
0040438 (Phosphotyrosine protein) phosphatases II 762-1062 1.3e-53 177.7 In-house 7-289 (317) alignment 
Range on Protein: 762-1062
Range on HMM: 7-289/317.0
KAIQYQMKENKTLLQEWLKSVYRALRTigETSVTNYDDNISERRHSMYICEPSTMAVLEGFK----NPFINANVMMFG--KIEWIMAQGPMdgtekkkde
.|... .| ..|.|.|. . ...      ..||... .|.. .|.. ... ...  .|  ..    . .|||. . .   | ..|..|||.         
lalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.........

tdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILL
      .|.|..| .. ...| . | |. ..| ...||| |...  |..| . ... .......       ....||.|.|....   ..... || .. 
.....pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl...gdsesrtvthfh

YSAWPEHGAPQEAYPALEILKFCETY----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
| .||.||.|.   . |..|......    .. |||||| |||||||..|. . .... |..   . ...  .|..|.||||   |  ..  .. . |. 
ytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr

KMPVPYLRSFD
|.. ... .. 
kltlepaselk
0050432 (Phosphotyrosine protein) phosphatases II 771-1051 3.8e-53 176.2 In-house 40-301 (308) alignment 
Range on Protein: 771-1051
Range on HMM: 40-301/308.0
NKTLLQEWLKSVYRALRtIGETSVTNYDDNISERRHSMYICEPSTMAVLeGFKNPFINANVMMFG----KIEWIMAQGPMdgtekkkdetdkpkRSTCEK
...||.|. . ...    ..|.||..  .|..  |.. ...  ..  .| . .. .|||. ...     . ..|..|||.               .|.|.
dlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.degsdYInAsyvdgyssklprkfIatqgPl..............pntved

HWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVG-GVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYRKNkgeQKKTVDILLYSAWPEHGAP
.| .. ..|| . | |. .|| . .||| |. ...| |.|.. ...........       ..|.|..|.|.||....   . .|| .. | .||.||.|
FwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdg...esrtvthfhytnWpdhgvP

QEAYPALEILKFCETY--KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
... . |..|......  .....|||| |||||||..|. . ...  |..   . ...  .|..|.|.||.  |  ..  .. . |. 
pspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
Y_phosphatase Protein-tyrosine phosphatase 800-1046 2.9e-51 169.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 800-1046
Range on HMM: 1-234/235.0
NISERRHSMYICEPSTMAVLEGFK--NPFINANVM--MFGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCAS
| . .|......  .|.  |.| .  . .||||..     | ..|..|||.               ||.|..|... |..| . |.|.  .| ...||| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPl..............kstiedFWrmvwqekvkvivmltsleekgrekcaq

YYSDKVGGVLRFRNYSLKTIdiktdLAEFTDKKDFTLYTVEITNYRKNKgeQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSE
|.... .. |.. ......        | .|.|..||...|...  ...  .|..|  | | .||.||.|... . |.... .|..|    ..|.||||.
Ywpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsa

GVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
|||||||.||... .. . ... ... .|.  .|..|.|.||. .|  ..  ...
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 800-1046 2.9e-51 169.5 In-house 1-234 (235) alignment 
Range on Protein: 800-1046
Range on HMM: 1-234/235.0
NISERRHSMYICEPSTMAVLEGFK--NPFINANVM--MFGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCAS
| . .|......  .|.  |.| .  . .||||..     | ..|..|||.               ||.|..|... |..| . |.|.  .| ...||| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPl..............kstiedFWrmvwqekvkvivmltsleekgrekcaq

YYSDKVGGVLRFRNYSLKTIdiktdLAEFTDKKDFTLYTVEITNYRKNKgeQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSE
|.... .. |.. ......        | .|.|..||...|...  ...  .|..|  | | .||.||.|... . |.... .|..|    ..|.||||.
Ywpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsa

GVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
|||||||.||... .. . ... ... .|.  .|..|.|.||. .|  ..  ...
GvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0045450 (Phosphotyrosine protein) phosphatases II 759-1047 3e-50 167.0 In-house 13-302 (307) alignment 
Range on Protein: 759-1047
Range on HMM: 13-302/307.0
HSVKAIQYQMKENKTLLQEWLKSVYRALRT-IGETSVTNYDDNISERRHSMYICEPSTMAVLEG-----FKNPFINANVMMF----------GKIEWIMA
..............|.|... .....   . .||.|....  |.. .|.. ... ..|  .|         . .|||. ...           | ..|..
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrk
|||...              |.|..| .. ...| . | |...|| ...||| |..|. |..| ..|.  .......       ....|..|.|.|..  
qgPlpe..............tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......ldgytvrtlevtdl..

NKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKV---TQIIDIILPVRQCRHGAVQ
.. ..  || .. | .||.||.|.   ..|.... ...       .. |||||| |||||||..|. . ...  | ..     . ...  .|..|.||||
dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavq

DDTQVTYILLCVTK
   |  ..  .. .
npeqyrflyealle
0047943 (Phosphotyrosine protein) phosphatases II 773-1046 5.6e-50 165.7 In-house 13-269 (273) alignment 
Range on Protein: 773-1046
Range on HMM: 13-269/273.0
TLLQEWLKSvyRALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMF--GKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWAL
.||.|. .   . | .....||... .|..  |.. ...  ... .|.. .. .|||. . .   | ..|..|||.               .|.|..| .
llleefell..lslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPl..............pntvedfwrm

IEQHNVAICVQLCGFVEGEDKKCASYYSDKVGG-VLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYRKNKgeqKKTVDILLYSAWPEHGAPQEAY
. ..|| . | |. .|| . .||| |.....|. .|.. ... ......|       |.|.|..|.|.||.  ..   ..|| ...|  ||.||.|.   
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtge...srtvthfhytgwpdhgvppsle

PALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
. ||.......       .. |.|||| |||||||..|. . .|.  |..   . ...  .|..|.|.||   |  ..  .. 
sllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
0051299 (Phosphotyrosine protein) phosphatases II 758-1046 2.8e-49 163.5 In-house 8-283 (288) alignment 
Range on Protein: 758-1046
Range on HMM: 8-283/288.0
DHSVKAIQYQMKENKTLLQEWLKSVYRALRTiGETSVTNYDDNISERRHSMYICEPSTMAVLEG----FKNPFINANVMMF--GKIEWIMAQGPMDgtek
.. .|.... .. ..|.|.|  . ... | . ...|....  |..  |.| ...  ..  .|        . .|||. . .   | ..|..|||..    
eellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp....

kkdetdkpkrSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYR-KNKGEQKKT
          .|.|..| .. ..|| . | |...|| . .||| |...  ||.| . ... .......       ..|.|..|.|.||..  .......|
..........ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrt

VDILLYSAWPEHGAPQEAYPALEILKFCETY----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
| .. | .||.||.|. . . |..|... ..    .. |.|||| |||||||..|. . ... .|...  . ...  .|..|.|.||   |  ..  .. 
vthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0046845 (Phosphotyrosine protein) phosphatases II 774-1052 8.5e-49 161.8 In-house 2-277 (284) alignment 
Range on Protein: 774-1052
Range on HMM: 2-277/284.0
LLQEWLKSVYRALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGFKN-----PFINANVMMFG-------KIEWIMAQGPMDGtekkkdetdkpkr
| .|. . .      . ..||...  |.|  |.. ...  ..  .|  ...      .|||. . .        | ..|..|||...             
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.............

sTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrkNKGEQKKTVDILLYSAWPE
 |.|..| .. ..|| . | |...|| . .||| |.... |.||.. ... .......       |.|.|..|.|.||.  . ... .|| .. | .||.
.tvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnl..gytgesrtvthfhytswpd

HGAPQEAYPALEILKFCETY------KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKK---VTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
||.|... . ||.|......      .. ..|||| |||||||..|. . ...  |..   .  . ...  .|..|.|.||   |  ..  ..   |. |
hgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
0039614 (Phosphotyrosine protein) phosphatases II 771-1053 3.6e-47 156.6 In-house 30-293 (297) alignment 
Range on Protein: 771-1053
Range on HMM: 30-293/297.0
NKTLLQEWLKSVYRALRtigETSVTNYDDNISERRHSMYICEPSTMAVLEGFKN-----PFINANVMMFGKI---EWIMAQGPMDGtekkkdetdkpkrs
.||||... .....      ..|...   |.. .|.. ... .... .| ....      .|||. . . ..   ..|..|||...              
sktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe..............

TCEKHWALIEQHNVAICVQLCGFVEGEDkKCASYYSDKVGgvlRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNyrknkGEQKKTVDILLYSAWPEH
|.|..| .. ...| . | |. .|| .  |||.|.....|   .. ... .......       ....|..| |.||     ... .||  ..|  ||.|
tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn.....ngesrtvthfqytgwpdh

GAPQEAYPALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKM
|.|. .   ||.|.....       .. |||||| |||||||..|. . .... |..   . ...  .|..|.|||| . |  ..  .. . |. |.
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
DSPc_SM00195 789-1047 3.2e-46 153.2 In-house 16-260 (263) alignment 
Range on Protein: 789-1047
Range on HMM: 16-260/263.0
IgETSVTNYDDNISERRHSMYICEPSTMAVLEGF----KNPFINANVMMF--GKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQL
  ||. .. . | |  |......  .|   |.      .. .||||.. .   | ..|..|||.               ||.|..| .. ...| | | |
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl..............pstvedFWrmvweekvkiivml

CGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLaeftdkKDFTLYTVEITNYRKnkgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK
. ..| . .||..|. .. ||  .| ..|.|... ...       ....|.|.|.|.  |   |....|  . | .||.||.|... . ||.|..... |
teeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksk

K----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.     ..|||| |||||||.|.|.. .. . ..|  .| .|.  .|. |.|.|| ..| ..|  .. .
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 789-1047 3.2e-46 153.2 In-house 16-260 (263) alignment 
Range on Protein: 789-1047
Range on HMM: 16-260/263.0
IgETSVTNYDDNISERRHSMYICEPSTMAVLEGF----KNPFINANVMMF--GKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQL
  ||. .. . | |  |......  .|   |.      .. .||||.. .   | ..|..|||.               ||.|..| .. ...| | | |
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl..............pstvedFWrmvweekvkiivml

CGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLaeftdkKDFTLYTVEITNYRKnkgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK
. ..| . .||..|. .. ||  .| ..|.|... ...       ....|.|.|.|.  |   |....|  . | .||.||.|... . ||.|..... |
teeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk...eetrkvtqyqyknWpdhgvpdstksvlellravkksk

K----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.     ..|||| |||||||.|.|.. .. . ..|  .| .|.  .|. |.|.|| ..| ..|  .. .
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0043336 (Phosphotyrosine protein) phosphatases II 761-1045 1.3e-45 151.4 In-house 8-273 (278) alignment 
Range on Protein: 761-1045
Range on HMM: 8-273/278.0
VKAIQYQMKENKTLLQEWLKSVYRALRtiGETSVTNYDDNISERRHSMYICEPSTMAVLEGFK----NPFINANVMMFG--KIEWIMAQGPMDGtekkkd
.||... .. .||||..  .....     ...|.... .|.. .|.. ... .... .|. ..    . .|||. . .   . ..|..|||...      
lkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......

etdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSdkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNyrkNKGEQKKTVDIL
        |.|..| .. ...| . | |...|| . .||| |..   ||.|.. ... .......       ..|.|..| |.||   ..  ...|| ..
........tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn...lgdgesrtvthy

LYSAWPEHGAPQEAYPALEILKFCET----YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
 | .||.||.|    . |..||.  .     .. |||||| |||||||..|. . ...  | .   . ...  .|..|.|||| . |  ..  ..
hylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0040439 (Phosphotyrosine protein) phosphatases II 791-1047 7.9e-45 148.8 In-house 2-244 (249) alignment 
Range on Protein: 791-1047
Range on HMM: 2-244/249.0
ETSVTNYDDNISERRHSMYICEPSTMAVLEG----FKNPFINANVMMF--GKIEWIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCG
|.||...  |.. .|.. ... .... .|.     | . .|||... .   | ..|..|||...              |.|..| .. .... . | |. 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..............tvedfwrmlwelgitvivmLts

FVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET----
.|| . .||| |...  ||.| . ... .......       |.|.|..|.|.||.   .  .. ||  . |  ||.||.|.   ..|.... ...    
lvelgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkalee

--YKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
   .. |||||| |||||||..|. . ...  |..   . ...  .|..|.|||| . |  ... .. .
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 785-1050 2.1e-44 147.4 In-house 18-273 (278) alignment 
Range on Protein: 785-1050
Range on HMM: 18-273/278.0
ALRTIGETSVTNYDDNISERRHSMYICEPSTMAVlegfknPFINANVMMFGKIEWIMAQGPMDgtekkkdetdkpkrSTCEKHWALIEQHNVAICVQLCG
.|  ..| .. .| .|..  | . ... .... .       .|||. ... . ..|..|||..              ||....| .. .... . | |..
llgipseitpalylgnldknRykdilpydhsrVk......dYINAsyidgypkkfIatqgPlp..............stvadfwrmlwelgitvivmlte

FVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTDlaeftDKKDFTLYTVEITNYRKNKGEqKKTVDILLYSAWPEHGAPQEA--YPALEILKFCET--
.||.. .||| |. .  ||.|.. ...........      |.   . ..|. ...... .| . .| .| |  ||.||.| .    . ||.|.|..   
lvelgrekcaqywpe..ggsltygdftvtllseevl.....ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefireal

---------------YKKNVLVHCSEGVGRTGTLVAIKYGIDLClkKKVTQIIDIILPVRQCRHG-AVQDDTQVTYILLCVTKGLM
                .. |||||| ||||||||||. . ..|.  ...  . ...  .|..|.| |||   |  ..  .. . |.
kllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 793-1045 5.9e-41 135.9 In-house 2-239 (245) alignment 
Range on Protein: 793-1045
Range on HMM: 2-239/245.0
SVTNYDDNISERRHSMYICEPSTMAVLEGFK----NPFINANVMMFGKI--EWIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFV
||...  |.. .| | ... ..|. .|   .    ...|||. . . .|   .|..|||...              |.|..| .. .... . | |. ..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..............tvedfwrmlwelgittivmLteee

EGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET-----Y
| . .||| |...  |..|.. ... .......       ..|.|..|.|.||    .  ....|  ..|  ||.||.|      |..|.|...      
elgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtnl...gddesrevihyhylpwpdhgvpdllellldflefvrkalaeds

KKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
.. |||||| |||||||..|. . ...  | .   . ...  .|..|.|||| . |  ..  ..
ngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 795-1045 1.4e-38 128.2 In-house 5-238 (243) alignment 
Range on Protein: 795-1045
Range on HMM: 5-238/243.0
TNYDDNISERRHSMYICEPSTMAVLEGfkNPFINANVMMFGKiEWIMAQGPMDGTEKKkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCA
 ..  |.|..|.| ... . .. .|||  . .|||| ..  .  .|  |||...| .           . ...| .. .... . | |. .|| . .|||
allpenlsknrysdilpydhsrvkleg..sdyinanliyvtp.rliatqgPlpetved..........dlasfwrmlwelgitvivmltelvElgrekca

SYYSdkvGGVlRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNyrKNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETY------------K
 |..   |.| .. ... .......       ..|.|..|....|  .. ......|  ..| .||.||.|..  . |..|... ..            .
qywp...gev.tygdftvtllseeh.......lddytvrtlllen..ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg

KNVLVHCSEGVGRTGTLVAIKYGIDLClkkKvTQIIDIILPVRQCRHG-AVQDDTQVTYILLCV
. |||||| ||||||||.|. . ..|.   .   . ...  .|..|.| |||   |  ..  ..
gpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_PTPN12_pd Subfamily PTPN12 827-1052 5.9e-32 105.7 In-house 71-280 (290) alignment 
Range on Protein: 827-1052
Range on HMM: 71-280/290.0
INANVMM--FGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDiktdlaEF
||||..    ||.|.| ||||.                | . .| .| ..|| | | .|  || . |||. |......  |.| ........      | 
inanfikgvegkleyiaaqgPL..............pktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee......ek

TDKKDFTLYTVEITNYrknkgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKV---TQI
. ..||.. |.....      .....|  . | |||.|| |. | . ||...  .....     ..|||| |||||||..|| |  .|  ..|.    ..
avdddflirtLkveaq.....kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldv

IDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
 |..| .|. |. .||   | ...  .|.. . ..
fdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 770-1041 1.4e-29 98.3 In-house 19-275 (305) alignment 
Range on Protein: 770-1041
Range on HMM: 19-275/305.0
ENKTLLQEWLKSVYRAlRTIGETSVTNYDDnISERRHSMYICEPSTMAVLEGFKNP---FINANVMM--FGKIEWIMAQGPMdgtekkkdetdkpkRSTC
.... |..  ||.|.   .  .   .. .   ..| ... . ... . . |  ...   .|||. .    .| ..|.||||.              ..| 
ysdkgleaqykslyee.eesidvgkkeank.aknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPl..............kntv

EKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKtidiktdLAEFTDKKDFTLYTVEITNYRKnkGEQKKTVDILLYSAWPEHGA
.  | || .  |   |.|.. |||...||  |. .... . .| ..|..       | ...  .|..   ..|.. ..   ....||  .    ||.|| 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsve.......lksektasdyieRklkisiede..dkesrtvlqyqltdWPdhGv

PQEAYPALEILKFCE-TYKKN----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
||.|   |...|  . ..||.    .|||||.||||||. .|..  .. . | .| .. ...  .|. | ..||   | ...
pqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 791-1040 6.2e-28 92.3 In-house 47-274 (290) alignment 
Range on Protein: 791-1040
Range on HMM: 47-274/290.0
ETSVTNYDDNISERRHSMYICEPSTMAVL-EGFKNPFINANVMMFGKIEWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGE
| .. . . ..   |.   .|.  |  .| .|..  .. || .   |  .|..||..              ..|    | .. |..||  | ||  .|  
erkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGal..............kdtvidiwrmvlqekvaaivmlceliedG

DKKCASYYSDKVGGVLRFRNYSLKTiDIKTDLAEFTDKKdftlyTveITNYRKNKGEQKKtVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHC
  ||. || .| | || | ....     ..|  . . ||     |  ..   |..| ..| .  |   .||..  .. .   | .|.   .    | |||
kakceqyypekeGevltfGeitvlc.seeddkdaniikk.....t..lsvrdkdsGkehk.lkhlkikswpdksvalstlallrtlrilrkasGpvvvhc

SEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTY
| |.|||||.|||. |... |. |  ...|..  .|..| ..|| |.|   
saGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 851-1050 8.9e-27 88.9 In-house 82-278 (307) alignment 
Range on Protein: 851-1050
Range on HMM: 82-278/307.0
KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSlKTIDIKTDLAEFTdKKDFtlYTVEITNYRKNKGEQKKT
||   .. |. .|  . ||.. |..|   . ||  .|    ||  |.  . |  | | . . .|| ..   |.     |     ...|. . . ... .|
kkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap.ntisvanlgakkl.apde..dlinvttlkvdwaqksrt

VDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGL
.. | .. ||..|.||    |...|.  .  .  |.|||| ||||.||.||| .  |  ..     .. ...  .|. || |.|.. |  |.   . . .
iqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

M
.
l
subfamily_PTPRB_pd Subfamily PTPRB 824-1052 1.6e-26 88.0 In-house 79-288 (293) alignment 
Range on Protein: 824-1052
Range on HMM: 79-288/293.0
NPFINANVMM--FGKIEWIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlrfrNYSLKTIDIKTDL
. .|||| .     . |.| .|||. .              | .. | .. .... | | |   ||.  .||  |. ..        . .    ||| .|
sDYinanyipgynsprefiatqGPlpe..............tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad........eepvlyGdikvtl

AEFTDKKDFTLYTVEITNyrknkGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVT
 . ....|... ...|..     ......|  . . .||.|| |... . |....  ....      . ..|||| |||||||..|..  ..   .. . 
vaeeeledwvirelkiek.....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyv

QIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
.|. |.  .|. |   ||  .|  .|  || . |..|
difgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 856-1047 5.9e-26 86.0 In-house 96-281 (290) alignment 
Range on Protein: 856-1047
Range on HMM: 96-281/290.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvgGVLRFRNYSLKTidiktdLAEFTDKkDFTLYTVEITNYRKNkgEQKKTVDILL
|. |  .|  . | || |..|.| | |.  .| . .||  |..|.  .. .. ..|.|       | | | . ...  ..|..| ...  ..|..|  . 
tqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikl......lneetln.eyierklevknknsa..gakqsvtqyq

YSAWPEHGAPQEAYPALE-ILKFCE----TYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 ..|...|  ..    |  | .  .    . .. ..||||..|||.....|.. .|. | .. | ......   |... | ||   |. .|   | .
itnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlt
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 793-1044 7.4e-26 85.7 In-house 28-265 (285) alignment 
Range on Protein: 793-1044
Range on HMM: 28-265/285.0
SVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVM-MFGKI--EWIMaqgpmdgtekkkdeTDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGE
. | |. |    |..   |   |  ||. .   .| |. | | ||    .|               |. |   |    | .| | ..|  . || ..|| 
tytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyit..............tqgplpetlsdfwhmiyqekiayvlmlctlfegg

DKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLAEFTdkkdfTLYTVEITNYRKNKGEQKKtVDILLYSAWPEHGAPQEAYPALEILKFCET---YKKNVL
 .||| || .|.| |..| .| .   . | .    |      | .. ..|      |    .. .    ||.. ||..| | .|. |. .     .| . 
vekcalyypeklgevvkfgkyeitlteckeeaiagt.....ilnaltvintedasseply.mnhvqvpwwpdqlapedarpmielykwvkkvnpkekpic

VHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLC
|||| ||||| |.| | |     ...   ...||.  .|  |  |||   |. .. . 
vhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvv
subfamily_PTPRD_pd Subfamily PTPRD 856-1045 8.2e-26 85.7 In-house 96-277 (564) alignment 
Range on Protein: 856-1045
Range on HMM: 96-277/564.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGgVLrfrNYSlktiDIKTDLAEFTDKKDFTLYTVEItnyRKNKGEQKKTVDILL
|  |. .|.|  | .. ..|... | |   .| . .||..|. .| |      .|     ... .| | ....|... | ..   .|.| .....|    
tqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.te...tyg....eltVtleeeeeladyeirtfkl...kkkkssesreVrqFh

YSAWPEHGAPQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
. .||.||.|..| . |.... ......     ..|||| ||||||| ..|.. ..   ..|.  |  ..  .|. |   ||  .|  .|   .
FtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheai
0041856 (Phosphotyrosine protein) phosphatases II 800-1053 1.3e-25 85.5 In-house 1-175 (182) alignment 
Range on Protein: 800-1053
Range on HMM: 1-175/182.0
NISERRHSMYICEPSTMavlegfKNPFINANVMMFGKIE--WIMAQGPMDGtekkkdetdkpkrsTCEKHWALIEQHNVAICVQLCgfvegedkkCASYY
|.. .|.| ... . ..       . .||||.....     .|..|||...              |..... .. .... . | |.         .  |.
nldknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls..............tvadflrmlkelgittivnlt.........eelyw

SDKVggvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqKKTVDILLYSAWPEHGAPQeAYPALEILKFCETYKKNVLVHCSEGVGRTG
 ...                                              ....  .||  || ||.|   . .|.... ..  ...|||||| ||||||
pell..............................................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtg

TLVAIKygidLCLKKKvTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKM
||||.     |..|..   . ...  ||..|.|.|.   |  .. |..   |. |.
tlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 825-1044 1.5e-25 84.7 In-house 49-259 (270) alignment 
Range on Protein: 825-1044
Range on HMM: 49-259/270.0
PFINANVMMfgkiewimaqgPMDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaef
 .|||| .             .|| .||   .  |. .| ...| .| ...|   | . |..|   |||. |.. ...  .....  .|.. ...     
aYinAnyvr...........GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalse.....

TDKKDFTLYTVEITnyrkNKGEQKKTVdILLYSAWPEHGAPQEAY------PALEILKFC----ETYKKN--VLVHCSEGVGRTGTLVAIKYGIDLCLKK
. .. . |  ....    .|||... |    | .||.||.|.|.         |..|.      .  .|.  .|||||.||||||||.|. ... |  ..
ekeegyiltrlrle....ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeet

KVTQIIDIILPVRQCRHGAVQDDTQVTYILLC
|  ... ||  .|. |   ||   |....   
kkvdvlaiieelRkdRmalvqhpeqyeflyka
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 855-1046 1.8e-25 84.5 In-house 94-276 (288) alignment 
Range on Protein: 855-1046
Range on HMM: 94-276/288.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVggvlRFRNYSLKTIDiktdLAEFTDKKDFTLYTVEITnyrknKGEQKKTVDIL
 |  |  .| .. | |. ....   | | ..|||...||  |. |.     . .||   |.     | |  ...||.| ....      | ... ..  .
atqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdad....kpknyGsvtvt....lveskeledfvlrkllle.....kkkteleitqy

LYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
 | |||.|| |. . | ||.|.  .. .    ....||||.||||||| .|..  ||   ....  .....  .|. |   ||  .|  .|  .. 
qylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 782-1051 2.4e-25 84.2 In-house 20-278 (281) alignment 
Range on Protein: 782-1051
Range on HMM: 20-278/281.0
VYRALRTIG--ETSVTN-YDDNISERRHSMYICEPSTMAVL----EGFKNPFINANVMM--FGKIEWIMAQGPMdgtekkkdetdkPkrSTCEKHWALIE
 |..|. ||  .|..    |.|. . |.|  .    |  ..    |  .. .|||| .    |. |.| .|||.            |  ..... | .. 
eyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPv............P..aslvafWqmvw

QHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlrfrnySLKTIDIKTDLAEFTDKKDFTLYTVEItnyrKNKGEQKKTVDILLYSAWPEHGAPQEAYPAL
...| . | .   .|..  ||  |. |.          .||  |..    . ..|. .   ....    .... ....|  | | |||.||.|...   |
eqkvsaivmvtreieagklkChrYWPddns........elkygdvtvkstaeeekatyierkfkl....eresgetreveqlaytaWPdhGvPattkell

EILKFC----ETYK-KNVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
|  |      |. .   ...||| ||||||| .|.   .. . .. . ... ...  .|. |   ||  .| ... . | . |..
efrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_PTPN3_pd Subfamily PTPN3 781-1051 4.8e-25 83.0 In-house 23-277 (280) alignment 
Range on Protein: 781-1051
Range on HMM: 23-277/280.0
SVYRALRTIgETSVTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFgkiewimaQGPMDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICV
 .||  . . ..|...  .|.|  |.   .   .|   |.  .. .|||| . .        . |  |. ..   |  | ..|... | .. .... . |
qlyrkkpgl.aisaarkpenlsknryrdilpydatrvklkesetdyinanyvnm........eipstglvnryiatqGPlaktatdfWqmvweqkssliv

QLCGFVEGEDKKCASYYSDkVGGVLRFRNYSLKTIDIktdlaefTDKKDFTLYTVEITNyrKNKGeQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET
 |   ||   .||  |. .  .  |.. ..|.|             .| . |  . ...  |..  .....  | | |||.|| |...   ||...  ..
mlttlverGrvkChqyWPe.tedeleygefsvkceke.......detksyvlrelvlkd..ketk.eerkilqlqylaWpdhgvPddsadflefvervrk

YK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLME
..    . |.|||| |.|||| |....  . |  ...   ..||.  .|. |   ||  .| ...  .. |  .|
lrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 792-1053 5.4e-25 83.0 In-house 35-275 (288) alignment 
Range on Protein: 792-1053
Range on HMM: 35-275/288.0
TSVTNYDDNISERR-HSMYICEpSTMAVLEGFKNPFINANVMMfgkiewimaqgpmD-GTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGE
 ..... .| .. | . .. |.  |   |.   . .|.|||.                  ...   .. | ..| |. | .. . .|   | || ..|  
diidsfianptrdryenlprcd.itrvklsddpdfyiaanvvs.............sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekG

DKKCASYYSDKVGGVLRFRNYslktidiktdlAEFT-DKKDFTLYTVEITNYRKNK-GEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLV
 .| | |.  |.|   |.. .              . .|..    .|...  | .| ||.|. | || .  |...| |..  . | .|.  ....| ..|
keksaeyfPsklGekarigrl...........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivv

HCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEKM
|.|.||||||||. |   ..    .    |  ..   |. |  |.|   |  |.  || . |. | 
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 854-1042 7.6e-25 82.5 In-house 76-261 (274) alignment 
Range on Protein: 854-1042
Range on HMM: 76-261/274.0
DETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLrfrnySLKTIDIKTDLAEFTDKKDFTLYTVEITNYRKNKGeqkktVDI
  |  |  .| .  | .| |..| . | |  . | . .||| |. |. .  .     | . .|..    . ....|... .. . .  ...      |  
vatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei.....serygdveikvekiverndysvrklvlkylerers.....vkh

LLYSAWPEHGAPQEAYPALEILKFCETYKK-------NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
 .|..||.| .|..| . |....  |. ..        |.|||| |.||||  .||. ..    ...|  .. |.  .|. | | || . |  .| 
ywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelih
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 822-1078 7.9e-25 82.6 In-house 44-269 (290) alignment 
Range on Protein: 822-1078
Range on HMM: 44-269/290.0
FKNPFINANVMMF-GKIEWIMAQGPMDGTekkkdetDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDK----KCASYYSDKVGGVLRFRNYSLKTid
|.. .| || . .   .. |. | |   .        . . || ||.| .. | .|   |.|| | | . .     || |. ..||. |.| . ..|   
fnddyiHAnrvtcpnglrliltqsPqeki.......tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC..

iktdlAEFTDKKDFTLYTVEITnYrknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCL-KKKVT
      .   ..|.   ..... .    .|.. ||.  |.. | .  ....   .|..... ...|  |.||| .|. |  .| ||. |  .   ... .
.....kskekeddvetRelvvk.f...ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsv

QIIDIILPVRQCRHGAVQDDTQVTYILLCVTkglmekmpvpylrsfdavqYYHKQLLNNFYHP
.. |..  .|. |  |...... ....  .                     . .. |..|...
kledvlkalrkqralaitsalelafvdagiv...................llaievldqfaee
0051429 (Phosphotyrosine protein) phosphatases II 857-1056 1.1e-24 83.0 In-house 28-232 (272) alignment 
Range on Protein: 857-1056
Range on HMM: 28-232/272.0
DKPKRSTCEKHWALiEQHNVAICVQLCGFVEGEDKKCASYYsdkvggvLRFRNYSLKTIDIKTDLAEFTD----------KKDFTLYTVEITNYRKNKGE
. | . |..  |.| .....   | |.. .| .  ||  |          .| . | ..|  .   .. .          . |..|.. ..|.. ...  
ggplpltaadfwrl.kelgiktivdLrseeErgrlkcdryw.......pgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

qkKTVDILLYSAWPEHGAPQEAypALEILKFCETyKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQ--------IIDIILPVRQCRHGAVQDDTQV
   .| .|.| .|| ||.||||   ||.|... . ...|||||| |..||||.||. . .    .  . .        . ...  .|..|.||||...|.
..revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqy

TYILLCVTKGLMEKMPVP
 ... .. . |.. . |.
lflyeallellrsllsvr
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 791-1047 3.1e-24 80.7 In-house 47-288 (298) alignment 
Range on Protein: 791-1047
Range on HMM: 47-288/298.0
ETSVTNYDDNISERRHSMYICEPSTMAVLEG----FKNPFINANVMMfgkiewimaqgPMDGTEkKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFV
|..|.....| .  |.. .|   |.  |||      .  .|||  .             ..|..     | .|  .| |  | .. .....  | |   .
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh...........aykgrn.afiatqaPltetvedFWrmvteedigtiVmltnle

EGEDKKCASYYSDKvggvlRFRNYSLKTIdiktDLAEFTDKKDFTLYTVEITnyrKNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK---
| .  |.  |. |.     . ..|   |.    .| .  .. |..  .....   |.| |....|  | .. ||..|.|..|   |..|.  .....   
eldktkyhkywPde.....gketygeitv....sllskeefadlivrklkvs...kkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqag

--NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
   |.|.||.||||.|| .||.  ..   |..|  . ...  .|. | ||||  .| ..|   | .
nkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavle
subfamily_PTPN13_pd Subfamily PTPN13 784-1041 4e-24 80.3 In-house 21-261 (273) alignment 
Range on Protein: 784-1041
Range on HMM: 21-261/273.0
RALRTIGETSVTNYDDNISERRHSMYICEPSTMAVLEGfKNPFINANVMmfgKIEWimaqgpmDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLC
| |... ...|.. ..| .. |.   .    |   |.. . ..|||. .   |..        .  | .   .  |   |..  | .. . .. . . . 
relkpldtcevgkkkenkdknryrnvlPydetrvklgd.eggyinasli...kvpv.......gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

GFVEGEDKKCASYYSDKVGGVLRFRNyslktiDIKTDLAEFTDKKDFTLYTVEITNyrkNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK
  .|..  ||  |. .. .  |  .|       .. .| . .....|.. ......   .. .. . |  | . .||.|| |..| . |....   . ..
lekekgkvkchrywPesknkklkvsn......rlevellkvqkldgfvvralavkd...sesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

---NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
    ..|||| |.||.|||..|.  ..|  ..|  .. .|.  .|. |.| || . |  ..
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifv
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 856-1042 7.9e-24 78.9 In-house 93-280 (305) alignment 
Range on Protein: 856-1042
Range on HMM: 93-280/305.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKtIDIKTDLAEFTDKKDFTLYTVEITNY-RKNKGEQKKTVDIL
|. |   ||   | .  |..|     || ..|   |||. |.. | . || |..   | | .| . ..  . .. .  .|. |    .  ||... |   
tqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk.isvkfessvtlkfrkdakakvtetvlviegpgekarkvthy

LYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQ-IIDIILPVRQCRHGAVQDDTQVTYIL
 .  ||. | |      ||.|. . . |  . |||| |.||||..| ..| .|  |  .. .    |.  .|. |  ..| |.|  .. 
hwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvh
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 828-1044 1.2e-23 78.3 In-house 66-276 (301) alignment 
Range on Protein: 828-1044
Range on HMM: 66-276/301.0
NANVMMFGKIE-----WIMAQgpmdGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDLA
  .|.  ||       || ..    |  ..   |  | ..|.|  ||.. |..|   | |. .|| . .||..|.. |..  |.   ...|. . .. | 
avevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkeliln

EFTDKKdftlyTVEITNYRknKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIIL
. . |.     |.|...    .  . .||    || |...| |.      .....    .| ..||||.|.||. .... .|     . ..  .. . . 
kkiskr.....tlevedst..gkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealk

PVRQCRHGAVQDDTQVTYILLC
 .|. |  .||  .|. .. | 
hlrehrwngvqtnsqlywmtlG
0036282 (Phosphotyrosine protein) phosphatases II 840-1042 1.4e-23 78.9 In-house 20-163 (174) alignment 
Range on Protein: 840-1042
Range on HMM: 20-163/174.0
IMAQGPMDgtekkkdetdkpkrstcekHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvggvlrfrnyslktidiktdlaeftdkkdftlytveitn
|  |||..                   .|... .... . |.|.  .| .  ||  |...                                        
iagqgpla...................fwemlkelgittvvmlleekelglykcinywpe........................................

yrkNKGEQKKTVDILLYSAWPEHGAPQEAYpALEILKFCETY-----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLkKKVTQIIDIILPVRQCRHGAVQD
   ..   ....  .||  || ||.|  .   ||..||.|..     .. |||||| ||||||||||. . . . |  .. ...|..  .|..|.|.|| 
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

DTQVTYIL
. |  .. 
psQyrfly
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 856-1045 1.4e-23 78.3 In-house 91-274 (287) alignment 
Range on Protein: 856-1045
Range on HMM: 91-274/287.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvLRFRNYSLKTIDIKtdlaeftDKKDFTLYTVEITNyrKNKGEQKKTVDILL
.. |  .|  . | ||...|| . | ||   | ....|  |....    . . .|... .. .        .....  ..|..|  ||| ..|..|    
aesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.......vnagyierklevkn..knkagdkqqvkqyq

YSAWPEHG-APQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
. .|...|  .. .   | | .   | .|     ..||||..|||.....|.  .|. | .  |  .....   |. . |.||  .| ..|   |
itnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindiv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 856-1052 3.9e-23 76.6 In-house 87-279 (312) alignment 
Range on Protein: 856-1052
Range on HMM: 87-279/312.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVlRFRNYSLKTiDIKTDLAEFTDKKDFTLYTVeITNYRKNKGEQKKtVDILL
|. |  .|| . | |      .  . ||||||   .||| | || || |  . .. . | .  |..      ||   . | .    |  |.. | ..   
tqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfv.dledhrvyt.eycteieiggkskdkithrv.lkvvvkatgqesk.lnhyq

YSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLMEK
...||.|| |.    || .|      || |. ||| ||||||||. |.  |    . .  .. |. . .|. |  .|.   |  | | || . |. |
waswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk
WSN Domain of unknown function 1-58 4.1e-23 71.1 Pfam-A 10-67 (69) alignment 
Range on Protein: 1-58
Range on HMM: 10-67/69.0
MQSLARLTNGISLEIGLIDGSIPSDDAIAELLHMGPVKLQELISMDTDAASKAITDLG
....||.||||.|. |||.||||.||.|||||..|...|..|...|.| ... ...| 
lsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 856-1066 1.1e-22 75.2 In-house 92-295 (315) alignment 
Range on Protein: 856-1066
Range on HMM: 92-295/315.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDlAEFTDKKdftlytVeITnyrkNKGEQKKTVDILL
.  |.... .  | .. |..|.  | .    ||.  ||. |. |. .   .| ...........| .. . .|      . .|     |.|...||    
sqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead.tdgvark......l.vt....rkseesrtvtqfq

YSAWPEHGAPQEAYPALEILKFCE----TYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLM-
.  ||..|.....   |...|       ... ..||||| |||||| ...|.  ..   ....  . ...  .|. |   || . . ..|   | . |. 
ftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllw

EKMPVPYLRSFDAVQY
 .  .. ..  | .| 
rntlilvihftdhlqd
subfamily_PTPRG_pd Subfamily PTPRG 855-1042 1.7e-22 74.4 In-house 95-280 (563) alignment 
Range on Protein: 855-1042
Range on HMM: 95-280/563.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvGGVLRFRNYSLKTIDIKTdLAEFTDKkdftlyTVEITNYRKNKG---EQKKTV
 | .| ..|..  | .| ..|||| | .  .|| . .||  |.     ..... . ... |. .. ||  | .      |. | | ...|.   ...|.|
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev.lalytvr......tlviknlklkkkkqcdteklv

DILLYSAWPEHGAPQEAYPALEILKFCETYKKN----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
    |. ||.||.|. . | |   |  .. .|.    ..||||.|||||||.....  .    .... .. ...  .|  |   ||.  | ... 
rqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflh
0043147 (Phosphotyrosine protein) phosphatases II 838-1042 2.4e-22 74.9 In-house 21-154 (172) alignment 
Range on Protein: 838-1042
Range on HMM: 21-154/172.0
EWIMAQGPmdgtekkkdetdkpKRSTCEKHWALIEQHNVAICVQLCGFvegedkkcasyysdkvggvlrfrnyslktidiktdlaeftdkkdftlytvei
..|. |||               |.|....|... .... . | |...                                                    
rfiatqgp..............lrntladfwrmlkelgithivnltel....................................................

tnyRKNKGEQKKTVDILLYSAWPEHGAPqEAYPALEILKFCET-----YKKNVLVHCSEGVGRTGTLVAIKYGIdlclkkK-VtQIIDIILPVRQCRHGA
    ...   ....  .||  || ||.|  .   ||.|.|...      .. |||||| ||||||||||. . .      . .  . ...  ||..| ||
...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpga

VQDDTQVTYIL
|| . |  ...
vqnpsqyrfly
0046846 (Phosphotyrosine protein) phosphatases II 856-1046 2.9e-22 74.7 In-house 28-170 (176) alignment 
Range on Protein: 856-1046
Range on HMM: 28-170/176.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkvggV----Lrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqkktv
|. | ..|... .... .... . | |.  || .  ||. |...    .    .                                              
tqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..............................................

dILLYSAWPEHGAPQEaYPALEILKFCETYK---KNVLVHCSEGVGRTGTLVAikygIDLCLKKKVTQIIDIILPVRQCRH-GAVQDDTQVTYILLCVT
   |.  ||.||.|.     ||.|.|....    ..|||||| |.||||||||    ..|. ..|   . ...  ||..|. |||| . |. ..  .. 
.qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_Ptp69D_pd Subfamily Ptp69D 790-1041 3e-22 74.1 In-house 38-278 (307) alignment 
Range on Protein: 790-1041
Range on HMM: 38-278/307.0
GETSVTNYDDNISERRHSMYIC---EPSTMAVLEGFK-NPFINANVMM-F-GKIEWIMAQGPMDgtekkkdetdkpkrSTCEKHWALIEQHNVAICVQLC
 .|.|.. ..|    |.   .    .   .....| .   .|||. .  .  | ..|.||.|..              .| .  | .| . .| . | | 
kstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve..............atigDfWRmiaeqevtlivmls

GFVEGEDKKCASYYSDKvgGVLRFRnyslktiDIKTDLAEFTDKKDFTLYTVEITNYRKNKGEQKKTVDILL--YSAWPEHGAPQEAYPALEILKFC-ET
   | ..|||| |...      ..        ||  .|...  ..|..  ......  .. || ...  ..   | .|..  .|. |   |....   | 
nlteknrkkcakYWpie..devqyg.......dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrel

YKKN---VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
||.|   ..|||| ||||.|..||..  .. . . .  .|....  .|. |   ||   | ...
yklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 851-1053 3.4e-22 73.4 In-house 96-293 (305) alignment 
Range on Protein: 851-1053
Range on HMM: 96-293/305.0
KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLktIDIKTDLAEFTDKKDFTLYTVEITnYrknKGEQKKT
|.   .. |   | .. | .. |..|   | ||  ||    ||| |.    |  | ...  .  ..  .    .    .  . ....| |    |.|| .
krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgiv..venvsgskpmerdaeiqitllnlt.y...sgdqkms

VDILLYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDL-CLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGL
|  | .. ||. | |     .||.|      |  ..|||| |.|||||.|||.| ..  . .|..  . ...  .|. |  ..|.| |  .|   . . .
vrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

MEKM
.|| 
leky
subfamily_PTPN6_pd Subfamily PTPN6 851-1046 4.2e-22 73.5 In-house 98-294 (306) alignment 
Range on Protein: 851-1046
Range on HMM: 98-294/306.0
KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLrFRNYSLKTIDIKtdlaeftDKKDFTLYTVEITNYrkNKGEQKKT
|.   |.   ..| .  | .. | |  . | .   ||   .||| |. |.      . ..|..... |       ...|..| .. ...   .|......
ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.......sladYilRelsvskk..kkkkeere

VDILLYSAWPEHGAPQEAYPALEILKFCETYKKN--------VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDI---ILPVRQCRHGAVQDDTQVT
|  . . .||.|| |.. .  |. |.  .. ...        ..||||.|.|||||.. |   ..|  ||..   |||   .  ||. | | || ..|  
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

YILLCVT
..   ..
fvykaik
0049260 (Phosphotyrosine protein) phosphatases II 856-1042 5e-22 73.7 In-house 14-143 (152) alignment 
Range on Protein: 856-1042
Range on HMM: 14-143/152.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYsdkvggvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqkktvdILL
|  | . |....| .. .... . | |. ..|    ||. |.                                                         |
tqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................................qyl

YSAWPEHGAPQEAYPALEILKFC----ETYKKNVLVHCSEGVGRTGTLVAIKYGIdlclkkKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
.  || ||.|. .   |..|.|.    .  ...|||||| ||||||||||. . .      .   . ...  ||..| |||.   |  ...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 856-1068 9.6e-22 71.7 In-house 91-296 (515) alignment 
Range on Protein: 856-1068
Range on HMM: 91-296/515.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTDlaefTdkkDFTLYTVEITnyrknKGEQKKTVDILL
.  |.... .  | |. |.||.  . .    ||.  ||. |. || |  ..| ....... ....    |   . .  .....     ||.. .||    
sqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac....t...ggikrkltvl.....kgddsrtvtqfh

YSAWPEHGAPQEAYPALEILKFC----ETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLM-
.  ||..|.|...   | ..|      . |.  ...||| |||||| ...|.  .    . ..  . ...  .|| |   || . | ..|   |   |. 
fteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw

EKMPVPYLRSFDAVQYYH
 .  .| .   | .|  |
rntlipvihftdhlqdlh
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 856-1047 1e-21 72.3 In-house 57-240 (250) alignment 
Range on Protein: 856-1047
Range on HMM: 57-240/250.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKkCASYYS-DKVggvlrfRNYSlktiDIKTDLAEFTDKKDFTLYTVEITNYRKnkgEQKKTVDIL
| .|  .| |. | .. .....  | |  ..| | . .  |.  .|       ..|     |.. .| .   . |.|  .. .....|   .....|  |
tqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka......ekyG....dvtvsllskeefadytkrklklskakk...aderivrql

LYSAWPEHGAPQEAYPALEILKFCETYKKN-----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 . .||. | |..|  .||.||  .. ...     |.|.||.||||.|. .||.  ..   |.||  . ..|  .|. | .||.  .|  ..   . |
hfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilk
subfamily_PTPRA_pd Subfamily PTPRA 856-1044 1.3e-21 71.8 In-house 106-290 (330) alignment 
Range on Protein: 856-1044
Range on HMM: 106-290/330.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvgGVLRFRNyslktidIKTDLAEFTDKKDFTLYTVEITNYRKNK-GEQKKTVDIL
.  ||. | |  | .| ... |  | |  . | ...||| |. |.  |.. . |       |.  . . |  .|.|.  . ...  ...  .... |  .
aqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGn.......irvevedetvlvdytvrkflvqqlpdatrekksrlvrqf

LYSAWPEHGAPQEAYPALEILKFCETYK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLC
 . .||. | | |.   |..||  .. .      . |||| |||||||.....  ..    ...  . ...  .|. |   || | | ..|   
hftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 855-1043 8.2e-21 69.4 In-house 95-277 (319) alignment 
Range on Protein: 855-1043
Range on HMM: 95-277/319.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlRFRNYSLKTIDIKtdlaEFTDKKDFTLYTVEItNYRKNKGEQkKTVDIL
 |  |.  | |  | .. .... | | |.. ||  . |.  |....      | .|   .....    |   ..|.    ... | .... |  ..|   
atqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.....nfeeyGrlivtle....eeeeledyiirklkl.nkkssevet.Revkhf

LYSAWPEHGAPQEAYPALEILKFCETYKKN-----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
 | .||.|. |..|   |..||  .  ...     . ||||.||||||| ....  ..   .  |  .  ..  .|  |   ||   | ..|  
qyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiye
PTPc_DSPc_SM00012 951-1045 8.4e-21 69.5 In-house 2-103 (105) alignment 
Range on Protein: 951-1045
Range on HMM: 2-103/105.0
VDILLYSAWPEHGAPQEAYPALEILKFCETYKK------NVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILL
|  . |..||.||.|.|. . ||.|. ... |.      .|.|||| |||||||.||. . .. . |. |  .| .|.  .|. |.|.|| ..|. ... 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CV
..
al
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 856-1047 9.7e-21 69.4 In-house 109-289 (319) alignment 
Range on Protein: 856-1047
Range on HMM: 109-289/319.0
TDKPKRSTCEKHWALIEQHNVAICVQLCgfvegeDKKCASYYSDKVggVLRFrnyslKTIDIKTDLAEFTDKkdFTLYTVEITNYRKNKGEQKktVDILL
.  |.  | .  | .| ..|..  | |        .||. |.  |.  | .      .  ..| |. | |..  ...  .|...  |.|. .|  .    
aqGPldntladfWrmiweyncstivllt......kdkcsqywplki..vike.....erfkvkvdsveetae..yvvrdielsedgkekdirk..itqfh

YSAWPEHGAPQEAYPALEILKF------CETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.  ||..| |. . . . ..|        |  ..|..|||| ||||||. ....  .|   ..|  .. ...  .|| |   ||| .|  .|   . .
flGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 848-1045 1.2e-20 68.7 In-house 24-217 (255) alignment 
Range on Protein: 848-1045
Range on HMM: 24-217/255.0
GTEKKKDETDKPKRS-TCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDiktdlaeftDKKDFTLYTVEITNYRKNKgE
. . .||.  |   | | .| .  | | .    | || | | . .|| ||.  .  . |.. . .. | .            |  | |.||| .  .|  
hvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.........ssadvvlrtleitstlgek.k

QKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYkKNVLVHCSEGVGRTGTLVAIKYGID---LCLKKKVTQIID---IILPVRQCRHGAVQDDTQVTY
. .||    |  |.|. ||..|   |.|||      | |.||||.|.||. ..| . .      . |..  |  .|   ..  .|. |..|...  |...
kthtvkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

ILLCV
 .| |
silmv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 856-1047 1.4e-20 68.9 In-house 73-253 (284) alignment 
Range on Protein: 856-1047
Range on HMM: 73-253/284.0
TDKPKRSTCEKHWALIEQHNVAICVQLCgfvegeDKKCASYYSDKVggVLRFrnyslKTIDIKTDLAEFTDKkdFTLYTVEITNYRKNKGEQKktVDILL
|  |.  | .  | .| ..|..  | |       ..||. |.  |.  | .      .  ..| |. | ...  ...  .|...  |.|. .|  .    
tqGPldntladfWrmiweyncstivllt......kdkcsqywplki..vike.....erfkvkvdsveesee..yvvrdielsedgkekdirk..irqfh

YSAWPEHGAPQEAYPALEILKF------CETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
.  ||..| |. . . . ..|        |  ..|..|||| ||||||. ....  .|   ..|  .. ...  .|| |   ||| .|  .|   . .
flgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 848-1045 2e-20 68.1 In-house 84-276 (318) alignment 
Range on Protein: 848-1045
Range on HMM: 84-276/318.0
GTEKKKD--ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlRFRNYSlktiDIKTDLAEFTDKKDFTLYTVEITNyrkNKG
| ..||    .  |   |.|  | .. . | |. | |   .|   .|.. |. .|       |.|     ... .| | .. .|..| ....|.   .. 
GyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk.....gsrsyg....klvvelkeevelsdyvlrefkvtr...tee

EQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK-----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTY
|....|    | .||..| |...   |....  ....     . ..|||| ||||||. .|..  ..   . ..  . ...  .|. |   || . | ..
eesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyef

ILLCV
|   .
iydvl
subfamily_PTPRK_pd Subfamily PTPRK 813-1043 3.1e-19 63.9 In-house 60-271 (314) alignment 
Range on Protein: 813-1043
Range on HMM: 60-271/314.0
PSTMAVLEGFKNPFINANVMmfgkiewimaqgpmDGTEKKKD--ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVggvlrfRNY
.  ... .  .. .|||...              |. .. .    | .|...| .  | |. ..| |  | |  .||    ||  |. ..       . |
vflitidgdpssdyinaali..............dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt......evy

SlktiDIKTDLAEFTDKKDFTLYTVEITNYRKNKgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYKK----NVLVHCSEGVGRTGTLVAIKYGI
     |||  | | . ....   .  ...  ... |....|  . . .||.|. |..|   |....  .. ..    ...|||| | ||||| .||.  .
g....dikvelvetellaelvvrifrveklargq.eeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivl

DLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
|.  ...|  .  ..  .|. .   |.   | ..|  
dmieregvvdvfnavktlrsrkvnmveteeqykfiyd
0044763 (Phosphotyrosine protein) phosphatases II 865-1047 3.6e-19 64.6 In-house 38-169 (178) alignment 
Range on Protein: 865-1047
Range on HMM: 38-169/178.0
EKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknkgeqkktvDILLYSAWPEHGA
.....|. ....   | |.. .|.   ||  |. .. |                                                    |.  .| ||.
addlellkelgithivnlteelelgflkcdpywpeeag.................................................iqylhipipDhgv

PQEAYPALEILKFCE----TYKKNVLVHCSEGVGRTGTLVaikyGIDLCLKKKVtQIIDIILPVRQCRHgAVQDDTQVTYILLCVTK
|.     ||...|.|    . ...|||||| ||||.||||     ..|..| ..  . ..|  ||..|  .|. . |. .....  .
pdllehflefvefieealdekggpvlVHCsaGvgRsgtlv....aaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_hpo-7_pd Subfamily hpo-7 852-1054 3.8e-19 63.6 In-house 31-232 (263) alignment 
Range on Protein: 852-1054
Range on HMM: 31-232/263.0
KKDETDKPKR----STCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaeftdkkDFTLYTVEITNYRKNKgEQ
.||.  |        | .| .  |.| .    | || | | . .|| ||.  .  . ... | .. | ...          |  | | |.... ..|  .
ekdkkrknlysllvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.........dvllktlellstlgeK.kk

KKTVDILLYSAWPEHGAPQEAYPALEILKFCETYkKNVLVHCSEGVGRTGTLVAIKYGID---LCLKKKVTQIID---IILPVRQCRHGAVQDDTQVTYI
 .||    |  |.|. .|..|   |.|||      |.. ||||.|.||.   . .        . |..  |  .|   ..  .|. |..|...  |. . 
thtvkhysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs

LLCVTKGLMEKMP
.| | . ... ..
ilmvLdfvlnnfa
subfamily_PTPN1_pd Subfamily PTPN1 819-1049 5.6e-19 62.9 In-house 51-271 (290) alignment 
Range on Protein: 819-1049
Range on HMM: 51-271/290.0
LEGFKNPFINANVMMFGKI--EWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlrFRNYSLKTID
||  .| .|||... . ..  ..|..|||.               .|..  | .. ...    | |  .|| |  |||.|.  .       ..  |. . 
leradndyinaslveleeakrsyiltqGPl..............pntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee....ekellledtk

IKTDLAEFTDKKDFTLYTVEITNyrkNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET------YKKNVLVHCSEGVGRTGTLVAIKYGIDLCL
.| .| .  .|. .|. ..|..|    | .. ...    | .||. | |.     |. |  .         .  ...||| |.||.||.. .   . |  
lkvkliseerksyytvrllelen...lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvlie

KKKV---TQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGL
||.     .| . .| .|. |.| .|   |. .  | . .| 
kkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 846-1042 6.3e-19 63.1 In-house 40-232 (237) alignment 
Range on Protein: 846-1042
Range on HMM: 40-232/237.0
MDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVggvlRFRNYSLKTIDIKTDlAEFTdkkDFTLYTVEITNYRKNKg
.||| ||   .. |  |.|.  | .. | . .. | | |..||...||  |. .      . . |   |. .| .  ||.   |.|. .. ...  . | 
fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd....qpaaygvltvslkkk.eefs...dytvrslllskrltlk.

eQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVT
 . . .    ...||..| ||..   | . |               ..||| |||||| .. |   .  . .||| .| . .  . . |   .|   |  
.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyv

YIL
.| 
fih
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 856-1042 7.2e-19 62.9 In-house 97-272 (315) alignment 
Range on Protein: 856-1042
Range on HMM: 97-272/315.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvggvlrfrN--YSLKTIDIKTDlaEFtdKKDFTLYTVeitnyRKNKGEQKKTVDI
.  |. .. .  | |. .....  | | . |||| .|.  |. ||        .  |   |.  | .  |   ....|  |.         |.. ..|  
aqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk........kviyGkitvtrkse..ev..nteytvrtl.....svvfgdnirevvq

LLYSAWPEHGAPQEAYPALEILKFCETYKKN----VLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
| |..||. | |. . | ... .    ...|    ..||||.|||||||.....  .|    ...  . ..|  ||| | ..||   |  .| 
lhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiy
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 855-1050 8.1e-19 62.9 In-house 96-285 (297) alignment 
Range on Protein: 855-1050
Range on HMM: 96-285/297.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGeDKKCASYYSDKvgGVLRFRNYSLKTIDIktdlaefTDKKDFTLYTVEITnyrKNKGEQKKTVDIL
 |..|...| .  ||.. ...|.. | |    |. ||||| |.|||  ||  | . |...  .       .... |   ..|.|   |.|  ... |.  
ttqmPmkatvadfWamvldeqvstivmlnddner.dkkcaryWsdk..gvttfGdvsvvllsv.......sereGfikrelevt...kgkakarrvvkqy

LYSAWPEHGAPQ-EAYPA-LEIL----KFCETYKK-NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 .  ||..  .. .  .. |...    |  .. ..  .||||. |||||| |..|.  .    ..|  .| ...  .|| |   || . | ...   | .
qfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle

GLM
 |.
all
subfamily_PTPN23_pd Subfamily PTPN23 856-1042 2.3e-18 61.0 In-house 88-273 (288) alignment 
Range on Protein: 856-1042
Range on HMM: 88-273/288.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNyslktidIKTDLAEFTDKKDFTLYTVEITNYRKnkgEQKKTVDILL
|  |..||    | .. .  . . | |    | ...|...|.  . |   .| .       ..  | . .. . .  ......  ..   ...|.|  | 
tqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.......lsvtlksvretethvervlkletlda...davksvshlq

YSAWPEHGAPQEAYPALEILKFCET--------YKKNVLVHCSEGVGRTGTLvAIKYGI--DLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
. .|||.|.|.     |..|.  |.         |. ..|||| ||||||.. |. |..  .|  .. ...||...  .|. |.  ||. .|.   .
ltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf.alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsy
0048076 (Phosphotyrosine protein) phosphatases II 934-1045 3.5e-17 57.9 In-house 35-139 (145) alignment 
Range on Protein: 934-1045
Range on HMM: 35-139/145.0
TVeitnyRKNKGEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETY---KKNVLVHCSEGVGRTGTLVAIkygiDLCLKKKVTqIIDIILPVRQCRHG
..       ..   ....  .||  || ||.|. .   ||.|.|.|..   ...|||||| ||||||||||.    .|.|...|. . ...  ||..|.|
nl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa....ylmlllgvs.leealelvrsqrpg

AVQDDTQVTYILLCV
||. . |. ......
avpnpgqlrflyefe
0051082 (Phosphotyrosine protein) phosphatases II 839-1044 6.4e-17 57.0 In-house 15-148 (151) alignment 
Range on Protein: 839-1044
Range on HMM: 15-148/151.0
WIMAQGPMDgtekkkdetdkpkrstceKHWALIEQHNVAICVQLCGFVEGEdkKCASYYSDKVggvlrfrnyslktidiktdlaeftdkkdftlytveit
 .  .||..                   ...|......   | |.. .| .  .|..|. .                                       
lyrsggpla..................dflellkelgiktivnlrseeerg..ycpeylpelg.....................................

nyrknkgeqkKTVDILLYSAWPEHGAPQEAYPALEILKFCETY-KKNVLVHCSEGVGRTGTLVAIKYGIdLClkkkvTQIIDIILPVRQCRHGAVQDDTQ
           .|  . .  ||..| |.    .||.|....   ...|||||| |.||||||||.   . |        . ...  .|..|.|.||  .|
..........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

VTYILLC
  ..|..
flfqlfa
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 856-1025 6.4e-17 56.1 In-house 86-244 (281) alignment 
Range on Protein: 856-1025
Range on HMM: 86-244/281.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaeftdKKDftLYTVEItNYrKNKGEQKkTVDILL
|. ||. |    | .| | | .  | || |.| . .||| |.  .   .|.| ..|..  |          .|   | |  . |    .|| .  .   |
tqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstv.......nks..lvttrl.nl.syegetr.lithwl

YSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLK-KKVTQIIDIILPVR
.  ||.   |. .   |.||.   .     ..||| ||||.|||.|..  ..       . .| .|.  .|
wkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlr
0048179 (Phosphotyrosine protein) phosphatases II 951-1043 7.6e-17 56.8 In-house 49-139 (144) alignment 
Range on Protein: 951-1043
Range on HMM: 49-139/144.0
VDILLYSAWPEHGAPQEAYPALEILKFCETY---KKNVLVHCSEGVGRTGTLVAIkygiDLCLKKKvTQIIDIILPVRQCRHGAVQDDTQVTYILL
.  .|.  || ||.|. .   ||.|.|.|..   ...|||||| ||||||||||.    .|..|..   . ...  ||..| |||. . |. ..|.
giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa....ylmkklg.lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPRN_pd Subfamily PTPRN 855-1047 1.4e-16 55.0 In-house 104-290 (297) alignment 
Range on Protein: 855-1047
Range on HMM: 104-290/297.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVlrFRNYSLKTIdiktdlAEFTDKKDFTLYTVEITNYRKnkgEQKKTVDIL
 |. |  ||  . | .. .. |.. |.|.   | . |.|. |. |.   |  .  | .. .      .|    .|. . .  . | ..   .. .||  .
atqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev..yhiyevhlv......sehiwcddylvrsfylknlqt...setrtvtqf

LYSAWPEHGAPQEAYPALEIL-KFCETYK---KNVLVHCSEGVGRTGTLVAIKYGIDLCLKK-KVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
 . .|||.|.| .| . ||   |   .|.     ..||||.|.||||. ..|   ..  ||  |  .|.  .  .|. |.| |.   |  ..| .|..
hflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN9_pd Subfamily PTPN9 846-1045 1.7e-16 55.2 In-house 78-286 (297) alignment 
Range on Protein: 846-1045
Range on HMM: 78-286/297.0
MDGTEKKKD--ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKTdlaeftdKKDFTLYTVEITNYRKn
.|| ..||    |  | . |.. .| .. ...| . |    .||    ||. |. .. . . .| ..|........       ..|..  ..||.| .. 
vdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.......eedykvrvleiknvkt.

kgEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCETYK-----------------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQ
  |....|    . .||..| |..|   |..|.    ..                   ..|||| |.|||||.... . ..   .. . .... .  .|.
..eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrt

CRHGAVQDDTQVTYILLCV
 |  ..| . | ..  |.|
qrafsiqtpeqyefcylav
subfamily_CG7180_pd Subfamily CG7180 856-1046 2.4e-16 54.2 In-house 90-287 (296) alignment 
Range on Protein: 856-1046
Range on HMM: 90-287/296.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDkKCASYYSDKVggVLRFRNYSLKTIDIKTdLAEFTDkKDFTLYTV--EITNYRKNKGEQKKTVDI
|. ||..| ...| |. ....   | |.   . .  .. ||.  |     ....  ....  |. .|...  . | |.     .|. .|.   ....|  
teapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekq.yanlki.rtfkltkkivalteqekqvkaetRivkl

LLYSAWPE-HGAPQEAYPALEILKFCETYKKNV---------LVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
. .  |.  .  |  .   .|...  ......|         .|..|.|..|.|  .||   ..|  |..  .. . .  .|. | . |.  ..  ||  
fqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd

CVT
 . 
vll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 848-1045 4.6e-16 53.4 In-house 80-289 (301) alignment 
Range on Protein: 848-1045
Range on HMM: 80-289/301.0
GTE--KKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDiKTDLAEFTDKKdFTLYTVEITN--Y--R
|.   ||   .. | ..|    | || |. ..  | ...  ||  .||  |...      .| . . . .. .. . .|. .. ...   . .|  |  |
gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvn.eqvyPdfvirq.lnvkiqdgsnngyier

K-NKGEQKKTVDILL--YSAWPEHGAPQEAYPALEIL-----KFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQ
| .. ..|.. |.|      ||..|  .|    |...     .     .  |.||||..|.|.|. ...  |.. |    |  .....  ||. . |||.
kfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVt

DDTQVTYILLCV
   | | |   .
TLeqytsiydvi
subfamily_PTPN14_pd Subfamily PTPN14 855-1044 5.1e-16 53.5 In-house 97-291 (300) alignment 
Range on Protein: 855-1044
Range on HMM: 97-291/300.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGgvlRFRNYSLKTIDIKTdlaEFTDKKDFtLYTVEITnYRKNKGEQKKTVDIL
 .  | . |....| .. ...|.. |.|    |.  .|. .|. ..     . ..   .   . |   .|... |  . |  ..  .    ....|| .|
vaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles...kkktvefgkfkvtt...kfsedsds.vittglk.lkhlpskeertvwhl

LYSAWPEHGAPQEAYPALEILKFCETYK-------------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
 |  ||.|| |..  . |. |.  .  .               ||||||.|||||| |.     |    . .. .|  ..  .|. |   ||  .| ...
qytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfv

LLC
   
Ykv
0049772 (Phosphotyrosine protein) phosphatases II 824-1038 2.6e-15 52.4 In-house 72-269 (314) alignment 
Range on Protein: 824-1038
Range on HMM: 72-269/314.0
NPFINANVMMFGkIEWIMAQGPMDgtekkkdetdkpkrSTCEKH----------WALI--EQHNVAICVQ---------------------LCGFVEGEd
  .|||. .      .| .|||..               |..            | ..  ...|| . |                      |... ..  
sdyinasyvdgf.lkfIatqgple..............itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.

kkcaSYYSDKVGGVLRfrnyslktidiktdlAEFTDKKDFtlytveitnyrknkgeqKKTVDILLYSAWPEHGAPQEAYpALEILKFCET--YKKNVLVH
    .... .    |.                | .|...|                 ....  .|.  .| ..|| ...  .|.|.|.|.   ...||||
....neptaadlellk...............eelydpelf.................erlgikylripvpDgsaplled.fdeflefieeadkggpvlvH

CSEGVGRTGTLVAIKYgidLCLKKKVtQIIDIILPVRQCRH-----GAVQDDTQV
|. |.|||||.|.. |   |... .|  . ...  ||..|.     |...   | 
CkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfieqleqy
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 848-1046 4.5e-15 50.5 In-house 48-237 (239) alignment 
Range on Protein: 848-1046
Range on HMM: 48-237/239.0
GTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNyslktIDIKTDLaeFTdkkDFTLYTVEITNYRKNkgEq
|. |    |.     ..   | .. |   .. | | |..||  |||  |. |       .|         ||..  |.   |. . |. ...  .   | 
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv.....tlrktev..fa...dyiirtfvmsqvgqt..e.

KKTVDILLYSAWPEHGAPQEAYPALE----ILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
.. |    .. ||..| || |   |     | |      .  ..||| ||||||... |   .  . |.|  .|.. .  .|. |   ||   |  .| |
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

CVT
.| 
avl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 848-1045 5.5e-15 50.2 In-house 49-237 (239) alignment 
Range on Protein: 848-1045
Range on HMM: 49-237/239.0
GTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNyslktIDIKTDLaeFTdkkDFTLYTVEITNYRKNkgEq
|. |    |.     ..   | .. |   .. | | |..||  |||  |. |       .|         ||..  |.   |. . |. ...  .   | 
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrv.....tlrktev..fa...dyiirtfvmsqvgqt..e.

KKTVDILLYSAWPEHGAPQEAYPALE----ILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILL
.. |    .. ||..| || |   |     | |      .  ..||| ||||||... |   .  . |.|  .|.. .  .|. |   ||   |  .| |
eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl

CV
.|
av
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 855-1066 8.6e-15 49.0 In-house 92-254 (392) alignment 
Range on Protein: 855-1066
Range on HMM: 92-254/392.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEdkkcasyysdkvggvlrfrnyslktidiktdlaeftdkkdftlytveitnyrknKGEQKKTVDIL
 .. |. .. .  | .. |.||.  . .  . ||.                                                      ||....||   
asqgpnaaslddfwrmvfqenvttiamvtklkegd......................................................kgddartvaqf

LYSAWPEHGAPQEAYPALEILKFCE----TYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTKGLM
 .. ||... |. .   |...|  .     | . ...||| |||||| ...|   .  . | .. ......  .|. |   || . | ..|  .| . |.
hftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledll

EK-MPVPYLRSFDAVQY
 .   .| ..  | .| 
wrntlipvvhftdhlqd
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 855-1045 1.2e-14 48.6 In-house 95-275 (439) alignment 
Range on Protein: 855-1045
Range on HMM: 95-275/439.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDkkcasyysdkvggvlrFRNYSLKTI--DIKTDLAEFTDKKDFTLYTVEITNYRkNKGEQKKTVD
.|. ||. |... | |. .....  |.|. .||                   .   . ...  ||        .  ....  . . | | ...|...|| 
atqgpkkettddfwrlviekktvtivmltnlvesyk................ywpsdaevcygdiavrvdrnielpnyvirgfkvfner.dttekertvl

ILLYSAWPEHGAPQEAYPALEILKFCETYK-----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCV
 . | |||..  | .|   |. |.  .. .       |.|||| |||||||..|.   ..    ..  .|  |.  .|. |.  ||.  |  .|  .|
qfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 856-1053 3.4e-14 47.7 In-house 96-288 (325) alignment 
Range on Protein: 856-1053
Range on HMM: 96-288/325.0
TDKPKRSTCEKHWALIEQHNVAICVqLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTIDIKtdlaEFtdkKDFTLYTVEITNYrkNKGEqKKTVDILL
.  |. .| .  | |. . . .. | .   .......|| |. ...|   .|    .| . |.    |.    |.    ... .   .|||  ..|  . 
aqaPltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrtie....ei...sdyvhrvldvkqv..kkGe.trsvkqfq

YSAWPEHGAPQEAYPALEILKFCETY----K------KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQvtYILlcV
. .|.. | ..     . ||.  ..     .        .|||||.||||||.....   ..  ...    | . .  .|. |   |.   |  |||  .
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdq..yil..i

TKGLMEKM
 ..|.| .
yealveay
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 794-1041 2.1e-13 44.8 In-house 27-258 (283) alignment 
Range on Protein: 794-1041
Range on HMM: 27-258/283.0
VTNYDDNISERRHSMYICEPSTMAVLEGFKNPFINANVMMFgkiewimaqGPMDGTEKKKDETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKC
..  |.|    |.   .     .  |.   . .|||  ..             .  .||   .  | . |    | .. .....  | |  . |....||
iasadenkrknrnqeivpadqwrvelksesrdyinavfipv.........sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

ASYYSDKvgGVLRFRNYslkTIDIKTDlaefTDKKDFTLYTVEITNYrknkGEQKKTVDILLY--SAWPEHGaPQEAYPAL---EILKFC--ETYKKNVL
. |.  .  |   . ..   |. .. .    | .. |.   . . .     .  |.|. .  |    | | | .|    .|   . ..    |  |  ..
sqyWPkr..GsedyGef...tvtlrke....ttsnsfiikelllrvn....ssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPiv

VHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
||||.|.|||....|.   ..  | . |  .  ..  .|. | .|||   |   .
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 856-1041 5e-12 40.4 In-house 77-251 (267) alignment 
Range on Protein: 856-1041
Range on HMM: 77-251/267.0
TDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEdkkCASYYSDKVGGVLRFRNYslkTIDikTDLAefTDKKDFTLYTVEItnyrKNKGEQKKTVDILL
| .| . |  ... .| ...|.. | |    ...      ..  |.|   ....    |..    |    ...|. . |.|.    | | |  . | .  
tqdplkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakkyqdl...tve..hsle..keendyqiitlel....kfknesahnvtlyy

YSAWPEHGAPQE-AYPALEILK--FCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
|  |      .    | . ||     |   . ..|.||.||||.||.. |.  ..   .  |..| | .. .|. | | |.   .  ||
ykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 858-1040 7e-10 33.1 In-house 87-268 (287) alignment 
Range on Protein: 858-1040
Range on HMM: 87-268/287.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKvGGVLRFRNYSLKTIDIKTDlaeftdKKDFTLYTVEITNYrknKGEQKKTVDILLYS
 |  .|  . | .. ....|  . .   ||   .||  |. ..    .|   ||.  .| .        . ...  .. . .    .... . |  | . 
gPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydik......ePeygvralrlidl...etrearvvkqldll

AWPEHGAPQE----AYPALEILKFCETYKK-----NVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTY
.||.....      .  .|.. .. |  ..      ..||.. |.||.|.|.|.   ..  ..     .  ... .|. | . ||   |. .
swPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 826-967 7.9e-10 33.1 In-house 61-182 (297) alignment 
Range on Protein: 826-967
Range on HMM: 61-182/297.0
FINANVMMFG----KIEWIMAQGPMDgtekkkdetdkpkrSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTidiktdL
.|||. ..|     .. .|.||||..              .| . .| |. ...| . | .. . |.  .||| |. . |.. |.  .. ..       |
yinadyvvfpdeeadlkyilaqGpls..............atvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvef......l

AEFTDKKDfTLYTVEITNYRKnkgEQKKTVDILLYSAWPEHGAPQE
....|. | ...  |.. . .   .... |    . .||.|| | .
sstsdefd.rviltelqliyr...sesrvvrhvqflswpdhGvpsd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 945-1050 7.4e-09 29.4 In-house 85-195 (440) alignment 
Range on Protein: 945-1050
Range on HMM: 85-195/440.0
GEQKKTVDILLYSAWPEHGAPQEAYPALEILKFCET-YK----KNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVT
| . .|.    | .||..| |. | | |....  .   .      .||||| |.|||| ..|.   .  . .    .|. .|  .|. |   ||   | .
giesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqya

YILLCVTKGLM
..  .| .||.
fvheavlegll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 858-1042 1.4e-08 28.7 In-house 101-283 (310) alignment 
Range on Protein: 858-1042
Range on HMM: 101-283/310.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDkVGGVLRFRNYSLKTIDIKTDLAEFTDK-KDFTLYTVEITNYRKNKgeQKKTVDILLY
 | . |    | .| |      . ||  .|    || .|.   .|    .    .  .   ..  |  .    |    | . .   |   ..  |... .
gplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanl..kelrvslikw

SAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
  ||. | |.|   ..    ...  .  ..|||| |..|....||.|. ||   . .  .. ...  ... |   .| . | ..| 
pnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliid
subfamily_CG42327_pd Subfamily CG42327 984-1042 3.9e-08 27.3 In-house 249-308 (319) alignment 
Range on Protein: 984-1042
Range on HMM: 249-308/319.0
NVLVHCSEGVGRTGTLVAIKYGID-LCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYIL
 . ||||.||||||...|    |  |   |.   | ...  ||. |  ||..  |  .| 
PlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiy
DSPc Dual specificity phosphatase, catalytic domain 922-1001 1.5e-07 26.4 Pfam-A 11-92 (133) alignment 
Range on Protein: 922-1001
Range on HMM: 11-92/133.0
AEFTDKKDFTLYTvEIT-NYRK---NKGEQKKTVDILlYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVA
 ....|...||   ..| . ..    | .... ..|       |    .|   | |... .|. .|.|||||  |. |..||..
lalleklgitlvi.nvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 922-1001 1.5e-07 26.4 In-house 11-92 (133) alignment 
Range on Protein: 922-1001
Range on HMM: 11-92/133.0
AEFTDKKDFTLYTvEIT-NYRK---NKGEQKKTVDILlYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVA
 ....|...||   ..| . ..    | .... ..|       |    .|   | |... .|. .|.|||||  |. |..||..
lalleklgitlvi.nvtkevpnnnaikkseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
0038934 (Phosphotyrosine protein) phosphatases II 971-1041 1.6e-07 26.7 In-house 99-169 (194) alignment 
Range on Protein: 971-1041
Range on HMM: 99-169/194.0
ALEILKFCETY-----KKNVLVHCSEGVGRTGTLVAIKYGIDLCLkkkvtQIIDIILPVRQCRHGAVQDDTQVTYI
 |..|......     .. |.|||  |.||||||||      |..        . |  .|..| ||..   .. ..
llrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.....saeeAialfrekRpgaipnqdyleal
subfamily_egg_pd Subfamily egg 805-1034 2.7e-07 24.6 In-house 45-255 (307) alignment 
Range on Protein: 805-1034
Range on HMM: 45-255/307.0
RHSMYICEPSTMAVLE----GFKNPFINANVMMFGKI--EWIMAQGPMdgtekkkdetdkpkRSTCEKHWALIEQHNVAICVQLCGFVEGedKKCASYYS
|  .  |. |.   ||     . . || || .  . .  |.|.|| |.              . | .  | .. | .|   | |   .|   ..|  |. 
rskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqapl..............kntvddfwrmvfqeevqyivmltsrkes..erceyywp

DKVGGVLRFRNYSLKTIDIKTDlaeftDKKDfTLYTveITNYRKnKGEQKKTVDiLLYSAWpEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGT
      |..   ||.   .| |     .| |  |..  .|. .   | ...    | .  . .     . |  |..|.      | |.|.. .|| ...|
kaesdslvtvpGslrienlkvd.....skad.plfr..vtklkl.vGgddeerf.lehwqg.dvnnssdvysplrvlrklrnlskpvvvqdilGvskaat

LVAIKYGIDLCLKKKVTQ--IIDIILPVRQCRHGAVQD
||||.  .   |.  .|.  .   .  .|. |. .|. 
lvaieiallsllrGpitkslvlravvflrlrrrlsves
PTPc_motif_SM00404 948-1002 2.9e-07 25.5 In-house 47-100 (140) alignment 
Range on Protein: 948-1002
Range on HMM: 47-100/140.0
KKTVDILlYSAWPEHGAPQEAYPALEILKFCETYKKNVLVHCSEGVGRTGTLVAI
.. . |   .   .    ..   .|.... .|. ...|||||  || |..||.. 
fqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia
subfamily_ptpA1_pd Subfamily ptpA1 855-1001 4.9e-07 23.8 In-house 93-248 (418) alignment 
Range on Protein: 855-1001
Range on HMM: 93-248/418.0
ETDKPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVlRFRNYSLKTIDIKTDLAEFTDKKDFTLYTVEITNYRKNKGEQKKTVDIL
 |. |   |    | .. .  . | | |    |    ||  |. ...||  .|  |      . |   |. .  .     .   | |     . . .   
ctqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.qfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqy

LYSAWPEHGAPQEAYPALEILKFCET--------YKKN--VLVHCSEGVGRTGTLVA
 |  ||.|  |. . |  ..|.              .|  ..|||| |||||||...
qyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 975-1047 5.9e-07 23.6 In-house 221-293 (297) alignment 
Range on Protein: 975-1047
Range on HMM: 221-293/297.0
LKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVTK
|.     .  .||||| ||||.| .|  .  ..   ||.. ..  |.  .|. |   ||   | ...   | |
lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 986-1041 1.6e-06 22.4 In-house 2-57 (69) alignment 
Range on Protein: 986-1041
Range on HMM: 2-57/69.0
LVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
.|||| | |||||..||   .     .|.  | . .  .|.||   | .. .  .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifi
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 987-1041 2.9e-06 21.5 In-house 2-56 (69) alignment 
Range on Protein: 987-1041
Range on HMM: 2-56/69.0
VHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYI
|||| | |||||..||   .     .|. .| . .  .|.||   | .. .  .|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfi
subfamily_CDC14_pd Subfamily CDC14 973-1036 3.6e-06 21.0 In-house 254-312 (328) alignment 
Range on Protein: 973-1036
Range on HMM: 254-312/328.0
EILKFCETYKKNVLVHCSEGVGRTGTLVAIkYgidlCLKKKVTQIIDIILPVRQCRHGAVQDDT
. |. .|. . .. |||  |.||||||.|  |     .|.   .  ..|  .| || | |    
kfleiaekaeGaiavhCkaGLGrtGtLiac.y....lmkhyrftaaeaiawlricrPGsvigpq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 983-1004 3.8e-06 20.9 In-house 263-284 (350) alignment 
Range on Protein: 983-1004
Range on HMM: 263-284/350.0
KNVLVHCSEGVGRTGTLVAIKY
. .||||| |||||||||.. .
spilvhCsaGvGrtGtlvtlDs
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 864-1046 5.1e-06 20.1 In-house 106-282 (302) alignment 
Range on Protein: 864-1046
Range on HMM: 106-282/302.0
CEKHWALIEQHNVAICVQLCGFVEGEDkKCASYYSDKVGgvlRFRNYSLKTIDIKTdlAEFTDKKDfTLYTVEITNyrkNKGEQKKTVDILLYSAWPEHG
 |. | .. |....  | | |  | .      ..  | |    . .|    . ..    | ....  | |..|.     .   .   . . . . |... 
veeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg...dykeygkmfvNnrk..Vekaeeek.tryviEvlP...egcsnsvlanvyvltnWkqkk

APQEAYP----ALEILKFCETYKKNVLVHCSEGVGRTGTLVAIKYGIDLCLKKKVTQIIDIILPVRQCRHGAVQDDTQVTYILLCVT
 |..       | .. .  .  ..|...   .|.|| |....    ..   |.|  .| .|.  .|. |  ||.  .| . . ... 
vpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
PTEN_1 982-1001 5.5e-06 21.3 In-house 130-149 (196) alignment 
Range on Protein: 982-1001
Range on HMM: 130-149/196.0
KKNVLVHCSEGVGRTGTLVA
...|||||  |.||.||.||
gnvVlVHCkaGlgRsGtvva
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 858-1033 7e-06 20.3 In-house 11-187 (198) alignment 
Range on Protein: 858-1033
Range on HMM: 11-187/198.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTidiKTdlaeFTDKKDFTLYTVEITNYRKNKGeQKKTVDILLYS
.| | |    | .. .      | .       .   . |..    |. .. . |. |   ||     | | |.|. .. .||         . .    ..
hplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt...kt....ittkpdytitaliltnnttapp.streishyqft

AWPEHGAPQEAYP------ALEILKFCETYK-KNVLVHCSEGVGRTGTLVAIKYGIDLCL--KKKVTQIIDIILPVRQCRHGAVQ
.| |. .|. |        . |. |  |  |   |.||||.| | || .||.  |.      |  | .....   .||.| | . 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 858-1033 7.3e-06 20.3 In-house 12-188 (199) alignment 
Range on Protein: 858-1033
Range on HMM: 12-188/199.0
KPKRSTCEKHWALIEQHNVAICVQLCGFVEGEDKKCASYYSDKVGGVLRFRNYSLKTidiKTdlaeFTDKKDFTLYTVEITNYRKNKGeQKKTVDILLYS
.| | |    | .. .      | .       .   . |..    |. .. . |. |   ||     | | |.|. .. .||         . .    ..
hplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvtt...kt....ittkpdytitaliltnnttapp.streishyqft

AWPEHGAPQEAYP------ALEILKFCETYK-KNVLVHCSEGVGRTGTLVAIKYGIDLCL--KKKVTQIIDIILPVRQCRHGAVQ
.| |. .|. |        . |. |  |  |   |.||||.| | || .||.  |.      |  | .....   .||.| | . 
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiis
subfamily_DSP23_pd Subfamily DSP23 973-1037 7.9e-06 20.6 In-house 75-134 (148) alignment 
Range on Protein: 973-1037
Range on HMM: 75-134/148.0
EILKFCETYKKNVLVHCSEGVGRTGTLVAIKYgidlcLKKKVTQIIDIILPVRQCRHGAVQDDTQ
....  |  .. | |||  | |||||..|  .     .|..     . |  ||. | |.|.   |
rvveeaeekneavsvhcllgrgrtgtmlacyl.....vkerklaaaeaiaevrrlrpgsvetveq
RhoGEF RhoGEF domain 142-253 8.2e-06 12.2 Pfam-A 65-176 (180) alignment 
Range on Protein: 142-253
Range on HMM: 65-176/180.0
QKGDTIDSITANFPRlYRDFN-KTENYAISFENVLSSLKLLDSIKN-MSLFLEPVYQeSAFRKELNLSTLTSVIYQALNQFSEQLQTIRKYVSNTKASES
.. .....|.  |    ..|    ..|   |...|. || | . .. .. ||. . . |   ..|.|..| ..  | | ..   |. . |. ..... ..
kekkdaqkigdvflk.leeflkvYseYisnfdkalkllkelskknskfkkflkeaee.spesskldLeslLikPvqRlprYplLLkellkatpeshpdye

DLKYIQRLINSLNS
.|. ..  |....|
alekaleaikevas