Gene K07F5.6 in Caenorhabditis elegans

Synonym: CELE_K07F5.6, K07F5.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf17
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP117_AA protein Get Run
CeleP117_AA_97-437 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 99-445 1.5e-232 765.2 In-house 1-347 (347) alignment 
Range on Protein: 99-445
Range on HMM: 1-347/347.0
FCKYLLDIKEASLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENSRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRD
|||||||||||||||||||.||.|.|..||||||||||||||||..||.|.|||.||||...|||.|...||||||||||||..||.|.|||||||||||
fckylldikeaslstyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrd

FWRMVSIMKVTQIVTIFEPQTDEAIEEFRNPTLTLAAPAPTSTMTTIGGFPVPIGQIAHNRDQIQGQSIRCESNVHRSSFFPLETDHYMNLKGWLINTRR
||.|||..||||.||||||..|||||||.|.||.|.|||||.....||..||||.|||..|.||...|||||||.|||||||||||||.||||||||||.
fwkmvsvtkvtqvvtifepikdeaieefanatlslvapaptasskdigsspvpidqiarereqieiksircesnlhrssffpletdhylnlkgwlintra

VTVDHRNKGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIA
|.||.|||.|||||||||||||||||||||||||||||||||||||||||||||||.|..|||||||||||||.|||||||||||||||||||||.|...
vevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvld

GKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIKLQTMND
|||||||.|||||||||||||||||||||||||||||.|.||||.|.
gktpdcddlfkkmrdqragvftmsifytyairaalfylklklqtlne
DSPc_SM00195 111-437 4.1e-78 257.7 In-house 2-263 (263) alignment 
Range on Protein: 111-437
Range on HMM: 2-263/263.0
LSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTEnsrtdPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQ
|...|..... ..| ..|..|..|. ||||.||....|.|||.|..|...     ....||||..||..|..|..|.||.|||.||.||||||. .||..
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvki

IVTIFEPQTDeaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgQSIRCESNVHRSSfFPLETDHYMNLKGWLINTRRvtvdhrnkGWMN
||...|....                                            ....|.......|    || .....| .  ....         ...
ivmlteeeen............................................gkekcdrywpees.ggketfgkisvklvevekkk........deii

KYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianlekLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKK
..|.|. .||..|......|....||....||..|.||.|.|| .|..|||        .||||.|. |..|..|.|...||.... ..|..|.....|.
lrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivke

MRDQRAGVFTMSIFYTYAIRAALFYMK
.|.||.|..... .|.....|.|.|.|
lRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 111-437 4.1e-78 257.7 In-house 2-263 (263) alignment 
Range on Protein: 111-437
Range on HMM: 2-263/263.0
LSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTEnsrtdPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQ
|...|..... ..| ..|..|..|. ||||.||....|.|||.|..|...     ....||||..||..|..|..|.||.|||.||.||||||. .||..
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk.....egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvki

IVTIFEPQTDeaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgQSIRCESNVHRSSfFPLETDHYMNLKGWLINTRRvtvdhrnkGWMN
||...|....                                            ....|.......|    || .....| .  ....         ...
ivmlteeeen............................................gkekcdrywpees.ggketfgkisvklvevekkk........deii

KYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianlekLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKK
..|.|. .||..|......|....||....||..|.||.|.|| .|..|||        .||||.|. |..|..|.|...||.... ..|..|.....|.
lrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivke

MRDQRAGVFTMSIFYTYAIRAALFYMK
.|.||.|..... .|.....|.|.|.|
lRkqRpgmvqtleqYlfiyeaileyik
0036941 (Phosphotyrosine protein) phosphatases II 107-444 1.3e-58 194.1 In-house 11-285 (297) alignment 
Range on Protein: 107-444
Range on HMM: 11-285/297.0
KEASLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILspentensrTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIM
  | |...|.| |  . .....  .... |.|||.|.   .|.|||.|         .|... |||||.... . ...||.||.|||.|| ||||||   
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.........ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

KVTQIVTIFEPQTDEAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLETDHYMNLKGWLINTRRVTVDhrNK
.|| ||.. |.  .. .                                                     ...|||...... ... .....|.|.  ..
nvtvIvmltelvelgrek..................................................caqywpleegesltygdftvtllsvevv..ll

GWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQII---AGKTPD
...  .|.||.  |..|  . ... .|.||. . |.. . .|.....  |  . .      .  |..|.|  |. ||.|...  ....|.      ...|
ddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll.....psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd

CDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIKLQTMN
   ..||.|.||.|....  .| . ..| |.. | ||. ..
ileavkklReqRpgavqtleqyrflyeallellkkkltkep
0040438 (Phosphotyrosine protein) phosphatases II 98-442 4.5e-55 182.5 In-house 4-282 (317) alignment 
Range on Protein: 98-442
Range on HMM: 4-282/317.0
GFCKYLLDIKEASLsTYFD---EHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPD
.....|||..  .  |..    |.|  .......  |.... .|||...  ..|..||.|||..      |....|||||.... | ...||.||.|||.
dlllalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg.....dldsdYInAsyvdgpnlkrkfIatqgPlpn

TVRDFWRMVSIMKVTQIVTIFEPQTDEAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLetDHYMNLKGWLI
|| ||||||   .|| ||.. |.  .. .                                                      ..||  ..... ... .
tvedFwrmvweqgvtvivmLteleelgrek..................................................caqYwpl..getltygdftv

NTRRVTVdhrnKGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTStslianlEKLAPIVVMCDLGLDRSATVVLTSIIID
... ...    .. .. .|.||.  |.||  . ... .|.||  . |.. . .|....|  .  .       ..  |..|.|  |..|..|...  ....
tllseee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.......dpggpvlVHCsaGvgRtGtfiaaylmle

QIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIKLQT
|.  ....| .  .|..| ||.|....  .| . ..|.|.|.| ||. 
qlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0050432 (Phosphotyrosine protein) phosphatases II 110-443 1.1e-54 181.3 In-house 43-306 (308) alignment 
Range on Protein: 110-443
Range on HMM: 43-306/308.0
SLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILspentensrtDPPDTYINASHIKFD--NSQKEFIVTQYPLPDTVRDFWRMVSIMK
 |...| | |. ........ ....  .|||.|.   .|..||.|          |....|||||....   .....||.||.|||.|| ||||||   .
lleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..........degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

VTQIVTIFEPQTDEAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLETD-HYMNLKGWLINTRRVTVdhrnK
|. ||.. ... .. .                                                      ..|||.. .... ... .......|    .
vrvIvmLtklvengrek..................................................caqYwplelgggsleygkftvtllseev....l

GWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTslianleklAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDA
... ..|.|..  |..|  . ... .|.||  . |.. . .|.....  |  .           ||||.|  |. |..|...  ....|. .....|   
ddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg.........gpivVHCsaGvGRtGtfialdllleqlekeggvdvfe

LFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIKLQTM
..||.| ||.|...    | . .||.|.|.| ||. .
avkklReqRpgmvqtpeqylflyralleylklkltkl
0047943 (Phosphotyrosine protein) phosphatases II 113-436 5.3e-53 175.6 In-house 16-272 (273) alignment 
Range on Protein: 113-436
Range on HMM: 16-272/273.0
TYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILspentensrTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
  |.. |  ... ...  .... ..|||.|.   .|..||.|         .|... |||||.... |....||.||.|||.|| ||||||   .|. ||
eefelllslkplltysvallpenkdknrykdilpydhsrvkl.........gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

TIFEPQTDEAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLETDH-YMNLKGWLINTRRVTVdhrnKGWMNK
.. |.. .. .                                                      ..||| .. ... . . ........    |... .
mLtelvelgrek..................................................caqYwpleggelsltygkftvtllseet....kddytv

YTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKD------TstslianleklAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCD
.|.|..  |..|  . ... .|.||  . |.. . .| ....  |                    |.||.|  |. |..|...  ...||.......| .
rtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn...........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvl

ALFKKMRDQRAGVFTMSIFYTYAIRAALFYM
 ..|..|.|| |...   .| . ..|.|.|.
eavkllrsqRpgmvqtpeqyrflyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 110-436 2.5e-51 170.2 In-house 24-286 (288) alignment 
Range on Protein: 110-436
Range on HMM: 24-286/288.0
SLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVT
 |   |.| |. ........  ... |.|||...   .|..||.||...      .....|||||.|.. |....||.||.|||.|| ||||||   .|.
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.....vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

QIVTIFEPQTDEAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLetDHYMNLKGWLINTRRVTVdhrnKGWM
 ||.. ... .. .                                                      ..||  ....... . .......|    .. .
vIvmltklvelgrek..................................................caqYwpl..ggsltygditvtllseev....lddy

NKYTVEVVAE----GCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTStslianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCD
 ..|.||.      |..|  . ... .|.||   .||. . .|...|. .|  .        .  |.||.|  |..|..|...  ....|. .....|  
tvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvl

ALFKKMRDQRAGVFTMSIFYTYAIRAALFYM
 ..|..| || |....   | . ..|.|.|.
eavkrlreqRpgmvqtpeqyrfvyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 117-436 1.1e-49 164.7 In-house 27-277 (278) alignment 
Range on Protein: 117-436
Range on HMM: 27-277/278.0
EHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
|.|  .......  ..... .|||.|.  ..|..||.||...      |....|||||.... | ...||.||.|||.|| ||||||   .|| ||.. |
eellsfkldtysiallpenkdknrykdilpydhsrvklsllgg.....dldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

PQTDEAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPletDHYMNLKGWLINTRRVTVdhrnKGWMNKYTVEV
.  .. .                                                      ..|   ..... ... ........    ....  .| ||
lvelgrvk..................................................caqYwp...ggsltygdftvtllkeeh....lddytvrtlev

VAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTStslianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRA
.  |..|  .  .| .. ||  . |.. . .| ...|  .  .        .  |..|.|  |..|..|...  ....|.  ....| .  .|..| ||.
tnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.......dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRp

GVFTMSIFYTYAIRAALFYM
| ...  .| . ..|.|.|.
gavqtpsqyrflyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 126-443 1.5e-49 164.3 In-house 19-281 (284) alignment 
Range on Protein: 126-443
Range on HMM: 19-281/284.0
NFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENSRTDppdtYINASHIKFD-----NSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTD
...   ... |||||.|.   .|..||.|.... . . .|    |||||....      ...|.||.||.|||.|| ||||||   .|. ||.. |.  .
slsvallpenlsknRykdilpydhsRVklksldgdledsd....YinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelven

EAIEefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLEtDHYMNLKGWLINTRRVTVdhrnKGWMNKYTVEVVAEG
. .                                                    . ..||| ......... .......|    |... ..|.|.. .|
grek..................................................caqYwple.gevltygdftvtllseev....kddytvrtleltnlg

-CSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTslianLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGK---TPDCDALFKKMRDQRA
 ..|  . ... .|.||  . |.. . .|...|.  .  .      |..  ||||.|  |. |..|...  ....|.....   ..|   ..|..|.|| 
ytgesrtvthfhytswpdhgvppspedlleflrlvrellen.....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp

GVFTMSIFYTYAIRAALFYMKIKLQTM
| ...   | . ..|.|.|.| ||. .
gmvqtleqyrfvyealleylklkltll
0039614 (Phosphotyrosine protein) phosphatases II 116-440 3.7e-49 163.1 In-house 38-293 (297) alignment 
Range on Protein: 116-440
Range on HMM: 38-293/297.0
DEHLAGYTPPnFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENtensRTDPPDTYINASHIKFDNS-QKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
 |.|  ..|. ..  ..... .|||.|..  .|..||.|.||.     .|....|||||.... .  ...||.||.|||.|| ||||||   .|| ||..
feellslkpd.ysiallpenkdknrykdilpydhsrvklkped....gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmL

FEPQTDEaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesNvHRSSFFPLETDhymNLKGWLINTRRVTVdhrnKGWMNKYTV
 ..  ..                                                  . .  ...| |..   . ... .....|..    .. .. .| 
tklvelg..................................................r.kcaqywpeegg...tygdftvtllkveh....ldgytvrtl

EVVAEGCSeaTFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQ
||. .|.|   . ... .| ||. . |.. . .| ....  .  ...     .|  |..|.|  |..|..|...  ....|.  ....| .  .|..| |
evtnnges..rtvthfqytgwpdhgvppslellleflelvrealael.....pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreq

RAGVFTMSIFYTYAIRAALFYMKIKL
| |....  .| . ..|.|.. | ||
Rpgavqtpsqyrflydallellkrkl
0045450 (Phosphotyrosine protein) phosphatases II 124-436 8.4e-49 162.3 In-house 44-304 (307) alignment 
Range on Protein: 124-436
Range on HMM: 44-304/307.0
PPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTEnsrtDPPDTYINASHI--------KFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIF
. .... ..... .|||.|.  ..|.|||.||... .    .... |||||..        .. .....||.||.|||.|| |||||.   .|| ||.. 
lgeysiallpenkdknrykdilpydhtRVklssldgs....ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmlt

EPQTdeaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircESNVHRSSFFPLEtDHYMNLKGWLINTRRVTVdhrnKGWMNKYTVE
|.                                                      ..    ..|.| ..... . . ........    .. .  .|.|
elve..................................................lgrekcaqywPde.geeltygnftvtllseeh....ldgytvrtle

VVAE-GCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKdtstsLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKT---PDCDALFKKM
|    |..|  . ... .|.||  . |.. . .|.....  |      ...| |  |..|.|  |..|..|...  ....|. ...|   .| .  .|..
vtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk.....aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkll

RDQRAGVFTMSIFYTYAIRAALFYM
|.|| |...   .| . ..|.|.. 
reqRpgavqnpeqyrflyeallell
0040439 (Phosphotyrosine protein) phosphatases II 126-436 1.3e-44 148.0 In-house 2-246 (249) alignment 
Range on Protein: 126-436
Range on HMM: 2-246/249.0
NFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEAIEe
...  .......|||....  .|..||.||. .       ... |||||.|.. .....||.||.|||.|| |||||.   ..| ||.. ...  . .  
eysvallpenkdknrypdilpydhsrvklsilpg.....lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrek.

frnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLetDHYMNLKGWLINTRRVTVdhrnKGWMNKYTVEVVAEGCSEAT
                                                    ..||  ..... ... .....|.|    |...  .|.|..  ...|  
.................................................caqywpl..ggsleygdftvtllsvev....kddytvrtleltnlydgesr

FAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFY
  .....| ||  . |.. . .|....|  |  ..      .|  |..|.|  |..|..|...  ....|.   .. | .  .|..|.|| |....  .|
tvlhiqytdwpdhgvppsfedlldfieavrkaleel.....pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqy

TYAIRAALFYM
 . ..|.|.. 
rflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 110-438 2.1e-43 144.1 In-house 8-274 (278) alignment 
Range on Protein: 110-438
Range on HMM: 8-274/278.0
SLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVIlspentensrtdppDtYINASHIKFDnsQKEFIVTQYPLPDTVRDFWRMVSIMKVT
.|...|.. |. . |  .|   ....|.||| |.   .|..||.              | |||||.|..   .|.||.||.|||.|| |||||.  ...|
dlllefefllllgipseitpalylgnldknRykdilpydhsrVk..............d.YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgit

QIVTIFEPQTDEaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesNVHRSSFFPlEtDHYMNLKGWLINTRRVTVDhrNKGWM
 ||.. | . ..                                                  ...   ..| | ..... ... ...  ..|   .. ..
vivmltelvelg..................................................rekcaqywp.e.ggsltygdftvtllseevl..ddytl

NKYTVEVV--AEGCSEATFAKVYNCTTWPWKKYPDDE--KKVLALVR-------APYKDTSTSLIANLEKlAPIVVMCDLGLDRSATVVLTSIIIDQIia
 ...|. .   .   |  . .......||    |...  | .| |..       . .. ...||... ..  |..| |  |..|..|.|.  ......  
rtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.gpvlVHCsaGvgRtGtlvaaylmlell..

GKTPDCDALFKKMRDQRAG-VFTMSIFYTYAIRAALFYMKI
... | .  .|..| || | ....  .| . ....| . . 
eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 128-436 2.8e-43 143.5 In-house 2-243 (245) alignment 
Range on Protein: 128-436
Range on HMM: 2-243/245.0
TSVEWEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEAIEefr
.. ..... .|||...  ..|.|||.|||...     |. ..|||||......  . ||.||.|||.|| |||||.   ..| ||.. |.  .. .    
svallpenkdknrysdilpydhtrvklspdgg.....dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvk...

nptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhRSSFFPLetDHYMNLKGWLINTRRVTVdhrnKGWMNKYTVEVVAEGCSEATFA
                                                  ..||  ..... ... ........    ....  .|.||. .|..|  . 
...............................................caqywpl..gesltygdftvtllseeh....lddytvrtlevtnlgddesrev

KVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTslianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTY
 .| .. ||  . ||. . .| ....  |  .        .  |..|.|  |..|..|...  ....|. . .. . .  .|..|.|| |....  .| .
ihyhylpwpdhgvpdllellldflefvrkalae......dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrf

AIRAALFYM
 ..|.|...
lyeallell
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 132-438 7.3e-28 92.4 In-house 25-270 (274) alignment 
Range on Protein: 132-438
Range on HMM: 25-270/274.0
WEKSLSKNRSKNHKLNDNTRVILSPENTEnsrtDPPDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQ--TDEAIEEFRN
  .| .||| |.   |.|.||.|..|..|    |.  .|||| .|| .|. .| .. || ||| || |||||.   .|. || . . .    .  ...  
vfgsqtknryktilPnensrvllesesse....dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

ptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhrssffpleT-------------DhymnlkgwlintrrvtVDHRNKGWMNKYTVE
                                                      .             .                .  ...   |.|.|.
......................................................daedyeiserygdve................ikvekiverndysvr

-VVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPykdtSTSLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQ
 .| . ...    | |  | || .| ||| ...| ||.      ..|  .. .||||.|| |  |. |    . .|| . |. . .. |   .  ..| .
klvlkylerersvkhywytdWPdhksPddantlldlvlev....eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrld

RAGVFTMSIFYTYAIRAALFYMKI
| |.   |  | .  ||   |.| 
rGGmvqtseqyelihralclylkr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 136-441 1e-21 72.2 In-house 21-269 (270) alignment 
Range on Protein: 136-441
Range on HMM: 21-269/270.0
LSKNRSKNHKLNDNTRVILspentENSRTDPPDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVtqivtifepqtdeaieefrnptltla
   ||...   . .|||.|     |. ..|.  .|||| ... ||...|..| .. ||| |...||||.   ||                          
kklnRyadiLPsPatRvrl.....eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekv..........................

apaptstmttiggfpvpigqiahnrD-QIQGQSIRCESNVHRSSFFPLETDHYMNLKGWLINTRRvTVDHRNKGWMNKyTVEVVAEGCSEATFakVYNCT
                            .    .  . . . . ..| |... ..|.   |...  . .....|.. .  ...  .| ..      .  .
.........................taivmttgleEkgrkkCerYWpaepkekvkledgkikvla.lseekeegyilt.rlrleekgeerrlv..Hfwyn

TWPWKKYPDDEK------KVLALVRApykdtSTSLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTY
||| .  | .|       ..|...||           .|.|  |..| |  |..|. |.... |..  .   |  |. |. ...| .|  .   .  |..
tWpdhgvpreedsslstdqllkmlra.....vrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyef

AIRAALFYMKIKLQ
. .| . |.. ...
lykavveyaerrak
Y_phosphatase Protein-tyrosine phosphatase 136-219 1.8e-21 72.0 Pfam-A 2-78 (235) alignment 
Range on Protein: 136-219
Range on HMM: 2-78/235.0
LSKNRSKNHKLNDNTRVILspenteNSRTDPPDtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQT
..|||.|.    |.||| |      .....| | ||||...|  ...|.||.|| ||..|. ||||||   ||. ||.. . . 
kkknRykdilpydktrvkl......kgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltslee
Y_phosphatase Protein-tyrosine phosphatase 136-219 1.8e-21 72.0 In-house 2-78 (235) alignment 
Range on Protein: 136-219
Range on HMM: 2-78/235.0
LSKNRSKNHKLNDNTRVILspenteNSRTDPPDtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQT
..|||.|.    |.||| |      .....| | ||||...|  ...|.||.|| ||..|. ||||||   ||. ||.. . . 
kkknRykdilpydktrvkl......kgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltslee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 276-442 2.8e-21 70.3 In-house 135-291 (302) alignment 
Range on Protein: 276-442
Range on HMM: 135-291/302.0
SSFFPLETDHYMNLKGWLINTRRvtVDHRNKGWmNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPykdtstsLIANLEKLAPIVVM
| .||.... | . .   .|.|.  |.. ..   ..|..||. ||||.. .|.|| .| |. || |.   .. . .             . .  ...|..
selfpkksgdykeygkmfvNnrk..Vekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv.......fakkikadentviv

CDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIKLQT
   |  | ....   . .... .|| |    . |..| ||. .    . |.   .|.|.|.| |...
SknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
0041856 (Phosphotyrosine protein) phosphatases II 136-440 2.8e-20 68.1 In-house 2-175 (182) alignment 
Range on Protein: 136-440
Range on HMM: 2-175/182.0
LSKNRSKNHKLNDNTRvilspentensrtdpPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEaieefrnptltlaa
|.||| ..   .|..|               . .||||. . ..  ...||.|| ||..|| ||.||.  ...| ||.. |.. .               
ldknrysdilpydhsr...............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp..............

paptstmttiggfpvpigqiahnrdqiqgqsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseA---TFAKVYNC
                                                                                                 | .
........................................................................................ellerlgiqyly

TTWPWKKYPDdEKKVLALVRAPYKdtstslianleKLAPIVVMCDLGLDRSATVVLTSIIIDQiiagkTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAA
. ||    ||   ..|..... ..           .  |..| |  |..|..|.|.  ... .       . .  .| .| .| |....  .| .  .|.
lpwpDhgvpd.ldelldfieevle...........eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlal

LFYMKIKL
|.... | 
lellllkk
Y_phosphatase Protein-tyrosine phosphatase 273-432 3e-18 61.5 Pfam-A 82-233 (235) alignment 
Range on Protein: 273-432
Range on HMM: 82-233/235.0
VHRSSFFPLETDHYMNLKGWLINTRrvtvdHRNKGWMNKYTVE--VVAEGCSE---ATFaKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTstslianLE
.. . ..| |.. ... .   ....     ...| ....||..   . . ..|    .. |.. .|.|| .. |.. |..| |.|.  |..        .
ekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk.......ea

KLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAA
| .|.||.|  |  |..|.|. .|...|. |....|   . |..| ||.|...    | . ..| 
ksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 273-432 3e-18 61.5 In-house 82-233 (235) alignment 
Range on Protein: 273-432
Range on HMM: 82-233/235.0
VHRSSFFPLETDHYMNLKGWLINTRrvtvdHRNKGWMNKYTVE--VVAEGCSE---ATFaKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTstslianLE
.. . ..| |.. ... .   ....     ...| ....||..   . . ..|    .. |.. .|.|| .. |.. |..| |.|.  |..        .
ekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk.......ea

KLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAA
| .|.||.|  |  |..|.|. .|...|. |....|   . |..| ||.|...    | . ..| 
ksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRD_pd Subfamily PTPRD 126-214 4.1e-18 60.3 In-house 37-122 (564) alignment 
Range on Protein: 126-214
Range on HMM: 37-122/564.0
NFTSV--EWEKSLSKNRSKNHKLNDNTRVILSPENTEnSRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
.||    . .   .||| .|    |..||.||. . . . .|    |||||.|.  ...|..| || ||..|..||||||   ... || .
qftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsD....YINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml
PTPc_DSPc_SM00012 328-433 4.6e-18 60.7 In-house 3-104 (105) alignment 
Range on Protein: 328-433
Range on HMM: 3-104/105.0
KVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSLIanlekLAPIVVMCDLGLDRSATVVLTSIIIDQIIAG-KTPDCDALFKKMRDQRAGVFTMSIFYT
|.| .|.||... |.. ...| |.||  | .. |        .|.||.|  | .|..|.|. .|...|. .. |..|   ..|..|.||.|....   | 
khyhytgwpdhgvPeesdsilellravkknknkses.....skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl

YAIRAAL
. .|| |
flyrall
subfamily_Ptp69D_pd Subfamily Ptp69D 132-216 8.7e-18 59.5 In-house 45-124 (307) alignment 
Range on Protein: 132-216
Range on HMM: 45-124/307.0
WEKSLSKNRSKNHKLNDNTRVILSPENTENSRtdppdTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
 .  . |||... |  |.|||.|.. | ...      .|||||.||  . .|.||. | |.  |. |||||..  .|| || . .
kkenalknRyedikafDktRvkLkkingkeds.....dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsn
subfamily_PTPRB_pd Subfamily PTPRB 134-214 1.4e-17 58.6 In-house 50-125 (293) alignment 
Range on Protein: 134-214
Range on HMM: 50-125/293.0
KSLSKNRSKNHKLNDNTRVILSPENTEnSRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
.  .||| .|    |..|| |.. ..| | .|    ||||..|.  ||..|||.|| |||.|| ||||||   |.. || .
vnraknrytnilpydhsrvkLaalkde.sgsD....YinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivml
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 134-214 1.7e-17 58.7 In-house 55-130 (298) alignment 
Range on Protein: 134-214
Range on HMM: 55-130/298.0
KSLSKNRSKNHKLNDNTRVILSPENTENSrTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
.  .|||  .    | .||.|. |....  .|    |||||...  . .. ||.||.||. || ||||||.  ... || .
enkkkNRyadiialdssRvvLekedadee.sd....YiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVml
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 129-215 2.2e-17 58.2 In-house 39-121 (305) alignment 
Range on Protein: 129-215
Range on HMM: 39-121/305.0
SVEW-EKSLSKNRSKNHKLNDNTRVILSPENTENsrtdpPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIF
 |.  |.. .|||.|.  | |. |.||.......        |||||...  ...|..||.| ||..||.||||..  .||..|| . 
dvgkkeankaknrlkeitlldddriiltekesld.....dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmlt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 134-220 2.5e-17 57.7 In-house 45-128 (290) alignment 
Range on Protein: 134-220
Range on HMM: 45-128/290.0
KSLSKNRSKNHKLNDNTRVILSPENtenSRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTD
..  .||..|  ..|. |..| | .   .. | .. ||||..||  . .|..|.|| |...|..|||...   ||| || . . . .
snkllnRfanivvyddnritLrpis...ghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniiee
0043147 (Phosphotyrosine protein) phosphatases II 165-428 5.6e-17 57.5 In-house 2-153 (172) alignment 
Range on Protein: 165-428
Range on HMM: 2-153/172.0
DPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPqtdeaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqg
|....|||||....    ..||.||.||. |. |||||.  ...| ||.. |                                                
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................

qsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseA-------TFAKVYNCTTWPWKKYPdDEKKVLALVRAPYKD
                                                                    .   | .. ||    | . . .| ...  .. 
...........................................................lydpellerlgiqylylpwpDhgvp.llellleflefidel

TstsliaNLEKLAPIVVMCDLGLDRSATVVLTSIIIdqiiagKTPDCDALFKKMRDQRAGVFTMSIFYTYA
       .|..  |..| |  |..|..|.|.  ...      .  . .  .. .|..| |...   .| . 
l......alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrfl
subfamily_PTPRG_pd Subfamily PTPRG 133-216 7.3e-17 55.8 In-house 45-124 (563) alignment 
Range on Protein: 133-216
Range on HMM: 45-124/563.0
EKSLSKNRSKNHKLNDNTRVILSPENTENSRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
...  |||  |    |..|| |||   .... |    ||||..|.  . .|.||.||.||.||. |||||.   .|. ||.| .
penkrKnRylnivaydrsRvklsplpgkkkklD....YinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitn
0037934 (Phosphotyrosine protein) phosphatases II 129-218 7.6e-17 57.1 In-house 4-83 (243) alignment 
Range on Protein: 129-218
Range on HMM: 4-83/243.0
SVEWEKSLSKNRSKNHKLNDNTRVILspentensrtdPPDTYINASHIKFDNsqkEFIVTQYPLPDTVRD----FWRMVSIMKVTQIVTIFEPQ
   .. .||||| ..  ..|..||.|           ... ||||..|.  .    .|.||.|||.|| |    ||||.   ..| ||.. |..
iallpenlsknrysdilpydhsrvkl...........egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 126-417 3.1e-16 53.8 In-house 36-217 (392) alignment 
Range on Protein: 126-417
Range on HMM: 36-217/392.0
NFTSVEWEKSLSKNRSKNHKLNDNTRVILspENTENSrtdPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEaiee
. |. . |  | ||| ||    |..||.|  |  ...   | . |.|||.|.  ...| .| .| | . .. ||||||   .|| |. . . .  .    
pqtvaqkeinlkknryknilpydsarvkl..eviddi...pdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....

frnptltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaEGCSEAT
                                                                                              | .  |
.............................................................................................kgddart

FAKvYNCTTWPWKKYPDDEKKVLALVrapyKDTStsliANLEKLA-PIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAG
 |. .  | || |  |     .| ..    |. .    |.  . . |... |  |. |.. |.    .. .    .  |   .  ..| .|  
vaq.fhftewPdkdvpkhtssllkfi....kevk....adfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 133-214 6.6e-16 53.2 In-house 39-115 (281) alignment 
Range on Protein: 133-214
Range on HMM: 39-115/281.0
EKSLSKNRSKNHKLNDNTRVILSPENTENsRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
..   ||| .|    |.||| ..|.....  ||    ||||....  ...||.|.|| |.|... .||.||   ||..|| .
denvlknrYsnivaYDatrvkvtpneenk.ntD....YinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv
subfamily_PTPN12_pd Subfamily PTPN12 131-213 7.2e-16 52.9 In-house 36-113 (290) alignment 
Range on Protein: 131-213
Range on HMM: 36-113/290.0
EWEKSLSKNRSKNHKLNDNTRVILSPENTENsrtdpPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVT
| |.   ||| |.    |..|| || .. |.      . ||||..||  ....|.| .| |||.|. |||||.  ..|. .| 
ekeenvkknrykDilPydksrvelskieeee.....gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvm
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 120-215 9.5e-16 52.7 In-house 33-123 (319) alignment 
Range on Protein: 120-215
Range on HMM: 33-123/319.0
AGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENSrTdppdTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIF
 . .. .|.| . |.  .||| .| .  |.|||.||. .  .. .    .|||||.|   . ...|| || || .|. ||||||   ..  .| . 
keavndtfdsaskeenkkknryqnilaydrtrvvlseldgveg.s....dyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmlt
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 136-214 1.2e-15 52.4 In-house 47-120 (318) alignment 
Range on Protein: 136-214
Range on HMM: 47-120/318.0
LSKNRSKNHKLNDNTRVILSPENTENSrTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
  |||  |    |.||| |.. ..|.. .|    ||||..|   ...|..| .| |||.|..||||||   . . ||..
kaknryanilaydhtrvkLqmlegeeg.sD....yinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 128-221 2.8e-15 51.0 In-house 37-125 (315) alignment 
Range on Protein: 128-221
Range on HMM: 37-125/315.0
TSVEWEKSLSKNRSKNHKLNDNTRVILspentENSRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDE
..   .   .||| ||    |..||.|     |    .| . |||||.||  ...| .| .| ||. .| ||||||   ||| || . . | ..
rvaretinfkknryknilPldsarvkl.....eviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegd
0049772 (Phosphotyrosine protein) phosphatases II 133-437 3.7e-15 51.9 In-house 44-281 (314) alignment 
Range on Protein: 133-437
Range on HMM: 44-281/314.0
EKSLSKNRSKNHKLNDnTRVILSPENTENsrtdppDTYINASHIKFDnsqKEFIVTQYPLPDTVRDF----------WRMV--SIMKVTQIVT-------
..  .|||...    | .||||. .. ..        |||||...     . ||.||.||. || ||          ||||  . ..|  ||        
flnrdknryldilpad.nrvilpglpvsg......sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevla

-----------------IFEPQtdeaieefrnptltlaapaptstmttiggfpvpigqiahnrdqiqgqS----------Ircesnvhrssffpletdhy
                 . ...                                               .                              
delsrLdaAlgKtpllildgng...............................................neptaadlellk...................

mnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseatfakV-------YncttwpwkkypddEKKVLALVRAPYKDTSTSLIA----------NLEKL
                                                  .             |. .. ..| |  | |. |..          ...| 
..........................................eelydpelf.............erlgikylripvpDgsaplledfdeflefieeadkg

APIVVMCDLGLDRSAT-VVLTSIIIDQiiagKTpDCDALFKKMRDQRA-----GVFTMSIFYTYAIRAALFYMK
 |..| |  | .|..| ||.  ... .    .  . .  .. .| .|      | . . . | .  .| | |.|
gpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 137-214 3.7e-15 50.7 In-house 49-121 (288) alignment 
Range on Protein: 137-214
Range on HMM: 49-121/288.0
SKNRSKNHKLNDNTRVILSPENTENSrTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
.||| .|    | .|| |   ..|.. .|    |||||.|. ....|..| || ||.||| |||..|   |.. || .
kknRyrnilpyDekrvklkkleeeag.aD....YinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 137-217 4.3e-15 50.5 In-house 49-120 (287) alignment 
Range on Protein: 137-217
Range on HMM: 49-120/287.0
SKNRSKNHKLNDNTRVILSpentensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEP
 |||...    || ||.|          .  . ||||..|.  ...|.||... |. .|.|.||...   .|| || . . 
dknRltqilvpdnyrvllk.........gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqe
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 135-214 4.5e-15 50.5 In-house 9-83 (250) alignment 
Range on Protein: 135-214
Range on HMM: 9-83/250.0
SLSKNRSKNHKLNDNTRVILSPENTENsRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
 . |||  .    |..||.| .|....  .|    |||||...  . .| ||.|| ||..|. ||||||   |.. || .
nkeknryadiialdssrvvLekekgdk.esd....yinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmL
0036282 (Phosphotyrosine protein) phosphatases II 168-428 9.2e-15 50.2 In-house 2-162 (174) alignment 
Range on Protein: 168-428
Range on HMM: 2-162/174.0
DTYINASHIKFDNSQKEFIVTQYPLPdtvrdFWRMVSIMKVTQIVTIFEPQTDE--AI-----Eefrnptltlaapaptstmttiggfpvpigqiahnrd
..|||||....    ...|..|.||.     ||.|.   ..| .|.  |.. ..   .     |                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

qiqgqsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaEGCSEATFAKVYNCTTWPWKKYPDDEKkVLALVRAPYKDTST
                                                             ..  .   | .. ||    ||... .| .|.. ..  | 
..........................................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse

slianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIaGKTPDCDALFKKMRDQRAGVFTMSIFYTYA
       .  |..| |  |..|..|.|.  ... ...  .. |  .|....| || |....  .| . 
......dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 135-222 1.6e-14 48.4 In-house 33-114 (283) alignment 
Range on Protein: 135-222
Range on HMM: 33-114/283.0
SLSKNRSKNHKLNDNTRVILSPENTensrtdppdTYINASHIK---FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEA
   ||| ..    |. || | .|.          .||||..|     .. .|..|..| || .||.|||.||   |.| || . . | |. 
nkrknrnqeivpadqwrvelksesr.........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlr
subfamily_PTPRK_pd Subfamily PTPRK 129-216 2.2e-14 48.0 In-house 37-119 (314) alignment 
Range on Protein: 129-216
Range on HMM: 37-119/314.0
SVEWEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
.   ..  .||||..    |..||.| . .      ||   ||||. |   .  ..|||||.||..||.||||.|   . . || . |
aakkdenreknrsgdilaydrsrvflitidg.....dpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 128-216 4.6e-14 46.4 In-house 36-119 (515) alignment 
Range on Protein: 128-216
Range on HMM: 36-119/515.0
TSVEWEKSLSKNRSKNHKLNDNTRVILspENTENsrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
|  . |   .||| ||    |..||.|  |  ..   .|   |.|||.|.  ...| .| .| |.. .| ||||.|   .|| |. . .
tvaqeeinfkknryknilPydsvrvkl..evind...nPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk
0046846 (Phosphotyrosine protein) phosphatases II 164-435 6.4e-14 47.6 In-house 8-172 (176) alignment 
Range on Protein: 164-435
Range on HMM: 8-172/176.0
TDPPDTYINASHIKFDnsqkEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEA------IEEFRNPTLtlaapaptstmttiggfpvpigqiah
 |.. .||||. |  .     .|.||.|||.|. ||..|.  ...| .|.. |..  .        .|.... .                          
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

nrdqiqgqsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseatfakVYNCTTWPWKKYPDDeKKVLALVRAPYKD
                                                                        | .. ||    ||. . .| |... .. 
.......................................................................qylhlpwpDhgvpdl.elllellefirea

TSTSlianleklAPIVVMCDLGLDRSATVVLtsiiIDQIIAGKTPDCDALFKKMRDQRA-GVFTMSIFYTYAIRAALFY
 .           |..| |  |. |..|.|.    .. .. .|  . .  ....|.||  |...   .| .  ...|..
lkeg........gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 134-219 6.8e-14 46.3 In-house 39-121 (301) alignment 
Range on Protein: 134-219
Range on HMM: 39-121/301.0
KSLSKNRSKNHKLNDNTRVILSPENTENSRTdppDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQT
.    || || .  |. |.||.|... .. .    .|||||.|.  ...|.||..| |.  |..||||..   |...||.. . . 
enkalnrfknitvyddnriilkpkpnldlcq...reyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 132-217 9.7e-14 46.2 In-house 48-126 (297) alignment 
Range on Protein: 132-217
Range on HMM: 48-126/297.0
WEKSLSKNRSKNHKLNDNTRVILSPENTensrtDPPDTYINASHIKfdNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEP
    ..|.| ||    |  ||.|   |.     ||   |.|||..|    ....| || | ..|| |||.||   .|. || . . 
kkvnfeksRYkniLPydssRvkLaivnd.....dpdsDyvnasfvk..gnkhrlittqmPmkatvadfWamvldeqvstivmlndd
0051429 (Phosphotyrosine protein) phosphatases II 168-438 1.1e-13 47.0 In-house 4-227 (272) alignment 
Range on Protein: 168-438
Range on HMM: 4-227/272.0
DTYINASHIKFDNS---QKEFIVTQYPLPDTVRDFWRMvSIMKVTQIVTIFEPQTDEAIEEFRNPTltlaapaptstmttiggfpvpigqiahnrdqiqg
..||||....  ..    . .. ...||| |..||||.   .... ||.. ..   ..   .| .                                   
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywp..................................

qsircesnvhrssffpletdhymnlkgwliNTRRV--------------------TVDHRNKGWMNKYTVEVVAE-GCSEATFAKVYNCTTWPWKKYPDD
                              . |..                    ..   ..  .  .. ... . . .||    .. .| ||   .|..
..............................girylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqe

EkkVLALVRAPYKdtstslianlekLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPD--------CDALFKKMRDQRAGVFTMSIFYTYAIRAALFY
.  .|.|...  .              |..| |  | ||..|||.  ... .. .    |         ..  ...|.||.|..    .| .  .|.| .
a..llellellld............ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel

MKI
.. 
lrs
subfamily_PTPRA_pd Subfamily PTPRA 127-216 1.3e-13 45.6 In-house 50-134 (330) alignment 
Range on Protein: 127-216
Range on HMM: 50-134/330.0
FTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENSrTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
.   . |.   |||  |   .| .|||||. . ... .|    |||||.|.  . ...|| .| |. .|| |||||.   | . || . |
lelaskeenkeknrvvnilPydfsrvilsvkeGvee.sd....yinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte
subfamily_PTPN9_pd Subfamily PTPN9 127-214 1.4e-13 45.6 In-house 34-116 (297) alignment 
Range on Protein: 127-214
Range on HMM: 34-116/297.0
FTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENsRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
|. ..    |.||| ..    |.||| |. .. ..  .|    ||||...   . .| || || ||. ||.||||||   .|  || .
flasklranleknrytdvlcydetrvvlakvdede.asd....yinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt
0049260 (Phosphotyrosine protein) phosphatases II 177-427 1.5e-13 46.2 In-house 3-141 (152) alignment 
Range on Protein: 177-427
Range on HMM: 3-141/152.0
KFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEAIEEFRNPtltlaapaptstmttiggfpvpigqiahnrdqiqgqsircesnvhrs
.. . ..||| ||.|.| |. |||||.  ...| ||.. |.. .  . . . .                                               
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................

sffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseatfakVYNCTTWPWKKYPDDEKKVLALVRAPYKDtstsliaNLEKLAPIVVMC
                                                     | .. ||    ||..  .| |...  |        .|.|  |..| |
....................................................qylhlpwpDhgvpdlsqlllflllfiekl.......aldkggpvlVHC

DLGLDRSATVVLTSIIIdqiiagKTPDCDALFKKMRDQRAGVFTMSIFYTY
  |..|..|.|.  ...      .  . .  .. .| .| |...   .. .
saGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf
subfamily_PTPN6_pd Subfamily PTPN6 135-212 2.2e-13 44.9 In-house 54-127 (306) alignment 
Range on Protein: 135-212
Range on HMM: 54-127/306.0
SLSKNRSKNHKLNDNTRVILSpentenSRTDPPDTYINASHIK--FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
  .||| ||    |.|||||.      .   | ..||||. ||  . .|.|..| ||  |..|| ||||||   . . ||
nkeknryknilPfDhtrvilk......epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrviv
subfamily_PTPN23_pd Subfamily PTPN23 136-218 2.7e-13 44.4 In-house 44-118 (288) alignment 
Range on Protein: 136-218
Range on HMM: 44-118/288.0
LSKNRSKNHKLNDNTRVILSpentensrtDPPDTYINASHIKF-DNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQ
 .||||..    |..|| |          .  | |||||..|       .||.|| ||. |. |||.||   |.  || . ...
seknrsrdilPyDhnRvklr.........gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllske
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 133-213 4.7e-13 44.0 In-house 46-121 (325) alignment 
Range on Protein: 133-213
Range on HMM: 46-121/325.0
EKSLSKNRSKNHKLNDNTRVILSPEntensRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVT
 .  .||| ||    |..||.|        . ||   |||||... |  .. |. .| ||..|. |.||.|   . . .| 
penkaknrfknvvaldksrvvletk.....kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv
subfamily_PTPN14_pd Subfamily PTPN14 128-216 9.9e-13 42.7 In-house 42-126 (300) alignment 
Range on Protein: 128-216
Range on HMM: 42-126/300.0
TSVEWEKSLSKNRSKNHKLNDNTRVILSPENtENsRTDppdtYINASHIKFD--NSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
.. . ..  .||| |.    ...|| ||| . || .|.    |||||.||     .....||.| ||. ||.|||.||   .|. || . |
staklpenaeknrfkdvlPyednrvelsptk.en.stg....yinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlte
subfamily_PTPN13_pd Subfamily PTPN13 134-216 1.4e-12 42.5 In-house 36-110 (273) alignment 
Range on Protein: 134-216
Range on HMM: 36-110/273.0
KSLSKNRSKNHKLNDNTRVILSPENTensrtdppdtYINASHIKF--DNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
.  .||| .|    |.|||.|. | .          |||||.||   .. . |.|..| |||.||.|||.||   |.. |. .  
enkdknryrnvlPydetrvklgdegg..........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 115-219 1.8e-12 41.7 In-house 13-112 (297) alignment 
Range on Protein: 115-219
Range on HMM: 13-112/297.0
FDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENsrtdppdTYINASHIKFDNSQKE--FIVTQYPLPDTVRDFWRMVSIMKVTQIV
 |  |    . .|.|   . || ||| ..    |.||| |    ||.        |||| .. | . ...  .|..| || .|| |||..|    |  ||
kdllldeargesfssakrnsslrknryrdilatddtrvkllrviter.......dyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrviv

TIFEPQT
 . . | 
mvaklqe
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 127-216 3.3e-12 40.8 In-house 30-113 (287) alignment 
Range on Protein: 127-216
Range on HMM: 30-113/287.0
FTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTENSrtdppdTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
| . |   . .|||  .    |.|||.|| |    |       |||| ..   . ...||..| |.. |||||||.|   ... ..|.  
fkaaeelaavkknryadvlPiddtrvllsaegelGs......dyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtr
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 136-214 3.6e-12 40.9 In-house 50-123 (315) alignment 
Range on Protein: 136-214
Range on HMM: 50-123/315.0
LSKNRSKNHKLNDNTRVILSpeNTENsrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
  |||  |    |..|| |    .||   ||   |.||. |.  | .. .| .| |.. .|.||||.|   ....|| .
kqknryiniiaydksrvqlp..llen...dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 111-216 4.4e-12 40.3 In-house 29-127 (290) alignment 
Range on Protein: 111-216
Range on HMM: 29-127/290.0
LSTYFDEHLAGYTPPNFTS-VEW--EKSLSKNRSKNHKLNDNTRVILSPENtensrtdpPDTYINASHIKFDNsqKEFIVTQYPLPDTVRDFWRMVSIMK
|.  . |.|  | | ..     .  .  . ||| |.   || |||||.           .  |. | ..|  .    ||.|| .| ||| |.||||   |
lakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGy........dGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqek

VTQIVTIFE
|. || . |
vaaivmlce
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 107-216 6.5e-12 40.0 In-house 7-111 (285) alignment 
Range on Protein: 107-216
Range on HMM: 7-111/285.0
KEASLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSpeNTEnsRtDppdtYINASHIKFD-NSQKEFIVTQYPLPDTVRDFWRMVSI
|  ..|  ..... || ||| |   .|     ||  . .  ..|||.|   | .  | |    || || ...  . |  .| || |||.|. |||.|.  
kcqaisklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlk..nhd..r.d....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyq

MKVTQI---VTIFE
 |.. .   .|.||
ekiayvlmlctlfe
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 128-214 8.1e-12 40.1 In-house 56-135 (319) alignment 
Range on Protein: 128-214
Range on HMM: 56-135/319.0
TSVEWEKslSKNRSKNHKLNDNTRVILSPENTENSRtDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
. .. .|   |||  |    |...| | . . |.   |    |||||...   ... .| .| ||..|. |||||.  .... || .
anldqnk..dknriinilafdknvvklerliGeefs.d....yinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 135-214 8.4e-12 40.2 In-house 25-99 (284) alignment 
Range on Protein: 135-214
Range on HMM: 25-99/284.0
SLSKNRSKNHKLNDNTRVILSPENTENSRtDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
   |||  .    |...| | .   |.   |    |||||.|.   ... .| || ||..|. |||||.  .... || .
nkdknrighilafdknvvklerliGeefs.d....yinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 134-231 1.7e-11 38.6 In-house 27-119 (267) alignment 
Range on Protein: 134-231
Range on HMM: 27-119/267.0
KSLSKNRSKNHKLNDN-----TRVILSPENTEnsrtdppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDEaIEEFRN
.|....  . ..|.||     |||||. .. |         |||||...  . .. ||||| ||  |. ||. ..   ||. || .    ||. |  |  
qsiaeknqernrlddnlpyddtrvilrtkeee.........yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdn.irlfwP

PTL
| .
Pkm
subfamily_PTPN1_pd Subfamily PTPN1 135-212 1.7e-11 38.3 In-house 32-100 (290) alignment 
Range on Protein: 135-212
Range on HMM: 32-100/290.0
SLSKNRSKNHKLNDNTRVILspENTENsrtdppdTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
  ..|| .. .  | .|..|  |...|        ||||| ..... ....|.|| |||.||  ||.||   |   .|
nrnlnryrdvspydhsrikl..eradn.......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv
subfamily_PTPRN_pd Subfamily PTPRN 130-221 3.9e-11 37.2 In-house 51-138 (297) alignment 
Range on Protein: 130-221
Range on HMM: 51-138/297.0
VEWEKSLSKNRSKNHKLNDNTRVILSPENTENSrtdppDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEPQTDE
 . || ..|||||.    |..|| |. |.....     . ||||| |   |  .  .| || ||..|| |||.||    |. ||.. . . ..
akaeknvkknrskavlpydhsrvklkeeasaek.....sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeeg
subfamily_PTPN3_pd Subfamily PTPN3 133-213 4.1e-11 37.3 In-house 39-114 (280) alignment 
Range on Protein: 133-213
Range on HMM: 39-114/280.0
EKSLSKNRSKNHKLNDNTRVILSpenteNSRTDppdtYINASHIKFDNSQ----KEFIVTQYPLPDTVRDFWRMVSIMKVTQIVT
 . ||||| ..    |.|||.|.     .|.||    ||||......       . .|.|| ||..|. |||.||   |.. || 
penlsknryrdilpydatrvklk.....esetd....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 131-226 4.4e-11 36.8 In-house 47-137 (302) alignment 
Range on Protein: 131-226
Range on HMM: 47-137/302.0
EWEKSLSKNRSKNHKLNDNTRVILSPEntensrtdpPDTYINASHIKFDNSQKEFIVTQYPLPDTV---RDFWRMVSIMKVTQIVTIFEPQTD-EAIEEF
 . | |.||.|.. .. |...|.|. |         || |.|||...  . ... |..| |  |..    .|||||   |....| .  ...  ....|.
afkknlkknqsedvpildsnlvkleae.........pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlsel
subfamily_egg_pd Subfamily egg 132-215 4.8e-11 36.9 In-house 37-115 (307) alignment 
Range on Protein: 132-215
Range on HMM: 37-115/307.0
WEKSLSKNRSKNHKLNDNTRVILspentENSRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIF
 .  | | |||  . .| .|| |     |  |    | .| | ..| .    |||..| || .|| ||||||   .|  || . 
sdnnlekarskrvhckdssrvkl.....elrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlt
0037934 (Phosphotyrosine protein) phosphatases II 321-435 6.9e-11 37.6 In-house 129-241 (243) alignment 
Range on Protein: 321-435
Range on HMM: 129-241/243.0
CSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTST--SLIANLEKlAPIVVMCDLGLDRSATVVLTSIIIDQIiagkTPDCDALFKKMRDQRAG-
  .  .   | .. ||  . ||. . .|..... ..  .   ||.|. ..  |..|.|  |..|..|...  ......    . | .  .|..|.|| | 
ddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgk

VFTMSIFYTYAIRAALFY
...   .| . ..|.|..
avqtpsqyrflyeallel
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 299-428 7.8e-11 36.6 In-house 146-272 (318) alignment 
Range on Protein: 299-428
Range on HMM: 146-272/318.0
VTVDHRNKGWMNKYTV---EVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRApykdtsTSLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQ
..|. ...  ...|..   .|  ....|    . |..|.|| .  |..  ..|.|||       .| . . ..  |||| |  |  |  . .  .|....
lvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq......vskaqqksgagpivvhCsaGvGrtGvfiavdiller

IIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYA
| | .. |     |..|.||  .      |.. 
ikaealvDvfqtvkqlreqrnlmvqtedqyefi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 109-215 1.2e-10 35.5 In-house 21-115 (303) alignment 
Range on Protein: 109-215
Range on HMM: 21-115/303.0
ASLSTYFDEHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSpentensrtDppDTYINASHIKFDnSQKEFIVTQYPLPDTVRDFWRMVSIMKV
| ...   |....| ||. .  .. | . |||  .    | ..| ||         |   .|| ||....| |.|  |.|| ||. |  |||.|.   ||
aniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls.........d..ssyihasyleld.sskkailtqlplshtaadfwqmiieqkv

TQIVTIF
  .. ..
kcvllll
subfamily_Ptp69D_pd Subfamily Ptp69D 330-437 1.4e-10 35.8 In-house 187-287 (307) alignment 
Range on Protein: 330-437
Range on HMM: 187-287/307.0
YNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianlekLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAI
|. |.|.  | |.  . .| |..  ..  ...        .|||| | .| .||...|  .....|. | .. |  .  |..| ||  ...    |..  
yhytgWkDskvPevargllklieqvrelykln.......rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvfly

RAALFYMK
|| | |..
ralldyss
subfamily_PTPN6_pd Subfamily PTPN6 329-442 1.6e-10 35.5 In-house 190-303 (306) alignment 
Range on Protein: 329-442
Range on HMM: 190-303/306.0
VYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSLIAnleKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKT---PDCDALFKKMRDQRAGVFTMSIFY
 |. ..|| .  | | . ||....   . ....  |   .  |||| |  |. |  |.... |....|   ..    |   | |..|.|| |.  .   |
qyhfksWPdhgvpkdpgavLdfledvnrkqeeleea...eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqy

TYAIRAALFYMKIKLQT
 .  .|  .|.. | ..
kfvykaikkyietkkkl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 135-214 1.9e-10 35.0 In-house 47-135 (350) alignment 
Range on Protein: 135-214
Range on HMM: 47-135/350.0
SLSKNRSKNHKLNDNTRVILS----PENTENSRTDPPDtYINASHIKFD------NSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
. .||| ||    . .||.|     . .. .  . . | ||||...|        |..  .| || ||| || ||....   ||. |...
lfaknrYknilPYehsrvkLkkslkssdakkhslstnD.YinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl
subfamily_CG7180_pd Subfamily CG7180 136-216 3.8e-10 33.9 In-house 43-118 (296) alignment 
Range on Protein: 136-216
Range on HMM: 43-118/296.0
LSKNRSKNHKLNDNTRVILSPENTENSrtdppDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFE
. |||  .    |..||.|.  . |..     . ||||...     .||.|||. |  .|| .|||.|   ..  .| . .
reknrdvkvvPyDynRvvLekldGeek.....sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk
0044763 (Phosphotyrosine protein) phosphatases II 160-431 9.1e-10 34.0 In-house 10-166 (178) alignment 
Range on Protein: 160-431
Range on HMM: 10-166/178.0
ENSRTDPPDTYINASHIKfDNsqkeFIVTQYPLpdtvRDFWRMVSIMKVTQIVTIFEPQT-------DEAIEEFRnptltlaapaptstmttiggfpvpi
.| .  .   |||||.|  ..    ......|      |.....  ...| ||.. |..         .. ||.                          
snleglersdyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.........................

gqiahnrdqiqgqsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseatfaKVYNCTTWPWKKYPDDEKKVLALVR
                                                                             | .. .|  . ||  . .|..|.
...........................................................................iqylhipipDhgvpdllehflefve

APYKDTstsliaNlEKLAPIVVMCDLGLDRSATVVLTSIIIDQiiagkTPDCDALFKKMRDQRAgVFTMSIFYTYAIRA
.  .        . ||  |..| |  |..||.|.|.  ... .       . .. .. .| .|  ...   .. . .. 
fieeal......d.ekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlrqLyef
subfamily_ptpA1_pd Subfamily ptpA1 131-213 1.9e-09 31.7 In-house 43-119 (418) alignment 
Range on Protein: 131-213
Range on HMM: 43-119/418.0
EWEKSLSKNRSKNHKLNDNTRVILSPENTENSrTDppdtYINASHIKFdNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVT
. ..  ||||  |    . ||| |   . ..  .|    |||| .|      |.||.|| |||.|. ||||||   ..  || 
dkkhntsknrytnilpvnhtrvqlkkiqdkeg.sd....yinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivm
subfamily_PTPRD_pd Subfamily PTPRD 313-437 2e-09 31.7 In-house 165-282 (564) alignment 
Range on Protein: 313-437
Range on HMM: 165-282/564.0
TVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTStslianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMR
| ..  .  ||.   . .. | || .  |.  ...|.|.|   . ..       ..  |||| |  |  |. | .  ......| . || |     |..|
tfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne.......pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalr

DQRAGVFTMSIFYTYAIRAALFYMK
 ||  .      | .  .| | ...
kqRnamVqteeQYiFiheaileala
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 299-433 2.6e-09 31.5 In-house 148-276 (288) alignment 
Range on Protein: 299-433
Range on HMM: 148-276/288.0
VTVDHRNKGWMNKYTVEVVAEGCSEAT-FAKVYNCTTWPWKKYPDDEKKVLALVRApYKdtstslIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQII
|||  ...  ....... .  . ..     . |. ..|| .. |.... .|.|.|   |      .|| ... ||.| |  |. |. | .    .||.. 
vtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrq.vk......vanqadtgpiivhCsaGvGrtgtFialdalidave

AGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAAL
. .. |  .  .|.| ||| .      | .  .. |
eedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 138-214 2.7e-09 30.8 In-house 51-138 (349) alignment 
Range on Protein: 138-214
Range on HMM: 51-138/349.0
KNRSKNHKLNDNTRVIL-----SPENTENS----RTDPPDTYINASHIKFD--NSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
||| |.    . .||.|     |.. ...|     .  .| |||| ..|.   . .| .| || ||| || ||....   .|  .. .
knrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 97-214 3.2e-09 30.8 In-house 12-127 (305) alignment 
Range on Protein: 97-214
Range on HMM: 12-127/305.0
KGFCKYLLDIKEASLSTYFDeHLAGYTPPNFTSVEWEKSLSKNRSKNHklNDNTRVILSPENTENSRTDPPDTYINASHIKFDN-SQKEFIVTQYPLPDT
. | .  ||.    |   |  .|| || |..| | ..   | . .. .  |  . |    ... .    .|  || | ..      .| ||..| || .|
eqfvlraldvgvdklreefr.glakytrpdmtqvafnanqsadiaitk..nryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqt

VRDFWRMVSIMKVTQIVTI
. .|| ||   || ||| .
idefwwmviqnkveqivml
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 133-214 3.5e-09 30.6 In-house 46-122 (439) alignment 
Range on Protein: 133-214
Range on HMM: 46-122/439.0
EKSLSKNRSKNHKLNDNTRVILSpenteNSRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
| . .||| |.    | |||.|      .    |   |||| .||    .| .| ||.|  .|. ||||.|   |...||..
eydqtknrykdvgafdhtrvtlq.....eipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 127-212 3.9e-09 30.5 In-house 44-123 (310) alignment 
Range on Protein: 127-212
Range on HMM: 44-123/310.0
FTSVEWEKSLSKNRSKNHKLNDNTRVILSpenTENSRTDppdTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
.|   ..| . |||  .    |..|| |     ..|| .    || | ..| .  .. ||..| ||  |. |||||.   .   |.
ltyeaykkymhknrysdvvcldtsrvklk...idksrye...dyihanyvktnylrstficsqgplqhtiidfwrmifqeraesil
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 137-213 5e-09 30.7 In-house 5-75 (237) alignment 
Range on Protein: 137-213
Range on HMM: 5-75/237.0
SKNRSKNHKLNDNTRVILSPENTEnsrtdppDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVT
 |||  | .  | .||.|    ..         ||||...| || . |..| .| ||  .  |||.||   | . || 
iknrygnivaydhsrvvlkgagsg.......sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivm
subfamily_PTPN13_pd Subfamily PTPN13 305-436 5.4e-09 30.7 In-house 146-269 (273) alignment 
Range on Protein: 305-436
Range on HMM: 146-269/273.0
NKGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRApykdtsTSLIANleKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDC
..  ..  ...|     .|.      | ..||  . |   ...| .|.          ...  . .|||| |  |. || |..   .... |   |  | 
kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvae......vrrlqt..dagPivvhcsaGiGrsGtlitidvvlglierdkefdv

DALFKKMRDQRAGVFTMSIFYTYAIRAALFYM
  . .|.|.|| ||   .  | .  .|.|  .
keivrklreqrqgvvqtkdqyifvykailevl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 306-436 5.7e-09 30.6 In-house 166-290 (298) alignment 
Range on Protein: 306-436
Range on HMM: 166-290/298.0
KGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKdtSTSLIanleKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCD
.. . . ...|  .  ..    .  . |.|| |  |  .. ||.|.|   .  |..      . .|..| |  | .|| | .  . ..... . .. |  
fadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra..sqqqa....gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvf

ALFKKMRDQRAGVFTMSIFYTYAIRAALFYM
   | .| .|.|. .    |..   | | ..
qvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 312-438 6e-09 30.1 In-house 172-289 (305) alignment 
Range on Protein: 312-438
Range on HMM: 172-289/305.0
YTVEVVAEGCSEAT-FAKVYNCTTWPWKKYPDDEKKVLALVRApykdtstsliaNLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKT-PDCDALFK
   ..| ||  | .  .. |    || .  |  .  .| |.                   |||| |  |. |. .||.   |.||..||.   |.| ...
tetvlviegpgekarkvthyhwidwpdrgvpaadlailellek...........arpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilq

KMRDQRAGVFTMSIFYTYAIRAALFYMKI
|.|.||         | .  .  | |.. 
kireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 353-439 7.2e-09 29.7 In-house 204-292 (305) alignment 
Range on Protein: 353-439
Range on HMM: 204-292/305.0
APYKDTSTSLIANLE-KLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGK-TPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIK
 | | ||  |.. .     |||| |  |. |. |.|    |...|   |  |    | | .|||||      . | .  |  | |.  |
ppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 104-214 9.2e-09 29.7 In-house 11-113 (307) alignment 
Range on Protein: 104-214
Range on HMM: 11-113/307.0
LDIKEASLSTYFDeHLAGYTPPNFTSVEWEKSLSKNRSKNHKLNDNTRVILSPENTensRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMV
||    .|   |   || .||   |   ..    ||| .. |  |..|...  .      .|    || | ..      | ||..| || .|. .|| |.
ldkgvqalvdefr.vlakktpegvtveafsantdknryqdvkcqdkgrivvkfdgl...asd....yihanylgiaikpkkficaqgplentqysfwama

SIMKVTQIVTI
   ||  .. .
iqekvesviml
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 161-212 1e-08 29.1 In-house 115-166 (244) alignment 
Range on Protein: 161-212
Range on HMM: 115-166/244.0
NSRTDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
 |.    .|||||| .       |.|.||.|| ||  |||.|.   .|  .|
lskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 277-421 1e-08 28.2 In-house 161-294 (346) alignment 
Range on Protein: 277-421
Range on HMM: 161-294/346.0
SFFPLETDHYMNLKGWLINTRRVTVDhrnkGWMNKYTVEVVAEGCSEATFAKVYNCTtwPWKKYpDDEKKVLALVRAPYKDTSTSLIANleklAPIVVMC
|.|  |   |      .|| ||  |     |  ..||.||. || |..  ..|.  .  |||.  ..  | | ...  ..  |   . |    | . |. 
slfndenggyqytgkmfinnrradvs....gdpkeytievlpegnsdsvicqvhhha..pwkhl.qqppktlpiikmihqflsekqvqn....agvcvvs

DLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTM
 .|  |. . . .   |.|.  |  |.   ..|....|| |    
lfgcgracsfigalyainqlnngiepniceimknikqqrpggves
subfamily_PTPN12_pd Subfamily PTPN12 305-445 1e-08 29.4 In-house 148-286 (290) alignment 
Range on Protein: 305-445
Range on HMM: 148-286/290.0
NKGWMN-KYTVEVVA-EGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTStslianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTP
.. ...  ...  .. |  .|    . .. | || .  |  .|..|.|...  .  .       .. ||.|| |  |  |  |..   .. ... |.|.|
eekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.......sedaPlvvhCsaGvGrtGtiiaidyvrellkaekip

DCDALF---KKMRDQRAGVFTMSIFYTYAIRAALFYMKIKLQTMND
..  .|    ..| ||| .      |..  .| . ... .|.....
eeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 332-436 1.6e-08 28.9 In-house 183-277 (307) alignment 
Range on Protein: 332-436
Range on HMM: 183-277/307.0
CTTWPWKKYPDDEKKVLALVRAPYKDTstslianleklAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKT-PDCDALFKKMRDQRAGVFTMSIFYTYAIR
 . || .  |. .   . |. |   ||            |.|| |  |. || |.|  |.. |..|||.   | . | ...|.||       . | |  |
wenwpdrgvpqinltainlleavrydt...........npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhr

AALFYM
  | |.
vlleyf
subfamily_PTPRG_pd Subfamily PTPRG 321-432 1.9e-08 28.0 In-house 179-283 (563) alignment 
Range on Protein: 321-432
Range on HMM: 179-283/563.0
CSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPykdtstsLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFT
| .    . |..|.|| .  |. .  ||  |.           || ..  |||| |. |  |. | .  . .. || . .. .   . |..| ||  ...
cdteklvrqyhytkWPdhgvPehslpvLifvkks.......saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvq

MSIFYTYAIRAA
    |..   | 
teEqYiflhdal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 313-436 2e-08 28.7 In-house 125-242 (250) alignment 
Range on Protein: 313-436
Range on HMM: 125-242/250.0
TVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianleKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMR
.. .  .  ..    . .. ..|| |  |.  . ||.|..   .    .      . ||..| |  |  || . .  . .....   |. |   . |..|
klklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa......gnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlr

DQRAGVFTMSIFYTYAIRAALFYM
 .| .. .    | .  ...| ..
kdrphavesleqyvfvyeiilkal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 170-215 4e-08 27.3 In-house 77-122 (301) alignment 
Range on Protein: 170-215
Range on HMM: 77-122/301.0
YINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIF
 | |  |. .   . ||.|| ||..|  ||| |.   .| .|| . 
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlg
0051082 (Phosphotyrosine protein) phosphatases II 167-427 4.7e-08 28.3 In-house 2-144 (151) alignment 
Range on Protein: 167-427
Range on HMM: 2-144/151.0
PDTYINASHIKFDnsqkeFIVTQYPLPdtvrDFWRMVSIMKVTQIVTIFEPQTDEAIEEF-R--Nptltlaapaptstmttiggfpvpigqiahnrdqiq
 ..|||.| .        ......||.    ||....  .... ||.. ...  .   |. .  .                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

gqsircesnvhrssffpletdhymnlkgwlintrrvtvdhrnkgwmnkytvevvaegcseatfAKVYNCTTWPWKKY--PDDEKKVLALVRAPYKdtsts
                                                                .|...  . |. .  |.  . ||.....  .     
...............................................................ievlhipildwpdpglplsfdavleflellld.....

lianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQiiagktPDCDALFKKMRDQRAGVFTMSIFYTY
      |  |..| |  |..|..|.|.  ... .       . .. .. .| .| ||.. .  . .
.....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 361-433 5.8e-08 26.9 In-house 220-292 (297) alignment 
Range on Protein: 361-433
Range on HMM: 220-292/297.0
SLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAAL
|| |.  . |...| |  |. ||  |||. .|....  .. ||  |. ...|.||| .      ...   |.|
slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 136-213 8.1e-08 26.3 In-house 49-118 (305) alignment 
Range on Protein: 136-213
Range on HMM: 49-118/305.0
LSKNRSKNHKLNDNTRVILSPENtensrtdpPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVT
  ||| |.    || || | .          |  || | ..      | || || || .|  ||| |    || .|  
agknrykdvgcldnnrvklegpw........pheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifm
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 132-214 8.3e-08 26.6 In-house 40-113 (288) alignment 
Range on Protein: 132-214
Range on HMM: 40-113/288.0
WEKSLSKNRSKNHKLNDNTRVILSpentensrtDPPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
. .. ...| .|    | ||| ||         | || ||.|  .   . .. .| .| ||  |.  .|.|.    |  || .
fianptrdryenlprcditrvkls.........ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivml
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 358-446 8.7e-08 26.6 In-house 179-270 (290) alignment 
Range on Protein: 358-446
Range on HMM: 179-270/290.0
TSTSLIANLE-KLAPIVVMCDLGLDRSATVVLTSIIIDQII-AGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMK-IKLQTMNDA
| .||| ... . .|..| |  |. |||..    .    |.   .     .. |..| ||| ..|  . ..... ....... .. |.....
tllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeee
subfamily_PTPN23_pd Subfamily PTPN23 277-437 1.1e-07 26.0 In-house 127-281 (288) alignment 
Range on Protein: 277-437
Range on HMM: 127-281/288.0
SFFPLETDHYMNLKGwlintRRVTV-DHRNKGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYK---DTSTSLIAnleklaPI
...| .... .. .       .||. ..|. . . ......  .. ..    .  . |.||    |.  ...|... .  .    .   . .      |.
rYwPedkgetvkfgd.....lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......Pl

VVMCDLGLDRSATVVLTSIIIDQIIAGK-TPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMK
|| |  | .|. .. |   .. .. .|.  .|   .....| ||  .   .  .  .  | | . .
vvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 137-212 1.6e-07 25.8 In-house 10-81 (239) alignment 
Range on Protein: 137-212
Range on HMM: 10-81/239.0
SKNRSKNHKLNDNTRVILspentENSRTDPPDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
.|||  |    | .||.|     |.   ||   |||||... .| | | .| ||  .  .  |||||.   .   ||
aknryanivtydhsrvvl.....eklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 137-212 1.6e-07 25.7 In-house 9-80 (239) alignment 
Range on Protein: 137-212
Range on HMM: 9-80/239.0
SKNRSKNHKLNDNTRVILspentENSRTDPPDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIV
.|||  |    | .||.|     |.   ||   |||||... .| | | .| ||  .  .  |||||.   .   ||
aknryanivtydhsrvvl.....eklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 364-439 1.8e-07 25.5 In-house 201-274 (288) alignment 
Range on Protein: 364-439
Range on HMM: 201-274/288.0
ANLEKlaPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIK
 .|.|  ||||..  |  |..|..|. |.....          |..|.|..|    .    | |. |  | .. .|
kslqk..PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
subfamily_PTPRB_pd Subfamily PTPRB 301-427 2.2e-07 25.2 In-house 154-276 (293) alignment 
Range on Protein: 301-427
Range on HMM: 154-276/293.0
VDHRNKGWMNKYTV-EVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYkdtstSLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAG
|.  ..  ...... |.  |  .| .  . |. |.||    |.. |..|..||.       . | . .. .|||| |  |. |. | .    ....|   
vtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvr.....eaiektaskrPivvhCsaGvGRtGtfialdrllqaieee

KTPDCDALFKKMRDQRAGVFTMSIFYTY
 . |  ..  ..| .|. .      | .
dyvdifgivaelReeRnllvqtekqYif
subfamily_PTPN14_pd Subfamily PTPN14 333-436 2.4e-07 25.1 In-house 191-296 (300) alignment 
Range on Protein: 333-436
Range on HMM: 191-296/300.0
TTWPWKKYPDDEKKVLALVRA--PYKDTSTSLIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIR
| || .. |.| |. |  ..     .  ..| . . |.  |..| |  |  |.  ..|. ..|  .  ... | .  ....| ||  .      |..  .
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYk

AALFYM
. . |.
vlikyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 306-439 2.6e-07 25.0 In-house 152-279 (281) alignment 
Range on Protein: 306-439
Range on HMM: 152-279/281.0
KGWMNKYTVEVVAEGCSEATFAKVyNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSLIanleklAPIVVMCDLGLDRSATVVLTSIIIDQIIAG-KTPDC
|  . . .... .|.. . . ... . |.|| .  |.. |..|   .. .| |...        ||.|. |  |  |. | .    ..... |  .. | 
katyierkfkleresgetreveql.aytaWPdhGvPattkellefrkevlkltekktk......aplvihCsaGvGrtGtyialDrlvkaveaeleeldv

DALFKKMRDQRAGVFTMSIFYTYAIRAALFYMKIK
.|. ...| .|  .    . |..  .| | ... .
kavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN3_pd Subfamily PTPN3 332-429 5.7e-07 23.7 In-house 178-268 (280) alignment 
Range on Protein: 332-429
Range on HMM: 178-268/280.0
CTTWPWKKYPDDEKKVLALVRAPYKDTstslianLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAI
 . || .. |||....| .|.   |           |  |.|| |  |..|.  ..|  . .  | | .     .. ..|||||| .   .  |..  
ylaWpdhgvPddsadflefvervrklr.......sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 167-209 5.9e-07 23.9 In-house 12-54 (130) alignment 
Range on Protein: 167-209
Range on HMM: 12-54/130.0
PDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVT
 .|||||| .   .  .|.. || || ||  |||.|.    | 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvn
subfamily_PTPRK_pd Subfamily PTPRK 273-432 5.9e-07 23.6 In-house 126-273 (314) alignment 
Range on Protein: 273-432
Range on HMM: 126-273/314.0
VHRSSFFPLETDHYMNLKGWLINTrrvtvDHRNKGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTslianleKLAPI
|. . ..| .|..| ..|  |..|     .  ..  .  ..|| .| | .|    . .. ..||  . |  .. .|.|||   | .         .  .|
vkClkyWPedtevygdikvelvet.....ellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.......eaGri

VVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAA
|| |  |  |. | .  .|..| |   .. |     |..|...  .      |..   ..
vvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN9_pd Subfamily PTPN9 296-436 7.7e-07 23.4 In-house 146-290 (297) alignment 
Range on Protein: 296-436
Range on HMM: 146-290/297.0
TRRVTVDHRNKGWMNKYTVEVVAEGcsEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTST--SLIANL----EKLAPIVVMCDLGLDRSATVVLT
 ..| |.....  ....... | ..  |      .  ..||    |.. ...| ....  .  ..  . ...      .  |||| |  |. |. | .  
vsnveveeeedykvrvleiknvkte..esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitl

SIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAALFYM
 | ....    | |     |..| |||    .   |..   | | | 
diclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 319-426 7.7e-07 23.5 In-house 172-273 (305) alignment 
Range on Protein: 319-426
Range on HMM: 172-273/305.0
EGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTSlianleKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGV
.. .|      |. |.|| .  |.    .| |..   || . .      |  |..| |  |. |. . .  .| .... . .. |   . |..| .| ..
dedkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd......kgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkm

FTMSIFYT
 .    |.
vqtldqYv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 135-214 8.2e-07 22.9 In-house 37-112 (281) alignment 
Range on Protein: 135-214
Range on HMM: 37-112/281.0
SLSKNRSKNHKLNDNTRVILSPENTENSRTDppdtYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTI
   |||  |    | .|| |  .  ..  ||    || | .|.    .. .|.|| |  .|  |||||.   . | || .
nnkknrylnipcldisrvqlkvkmpnknstd....yihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml
subfamily_eak_pd Subfamily eak 166-224 8.2e-07 22.7 In-house 76-133 (332) alignment 
Range on Protein: 166-224
Range on HMM: 76-133/332.0
PPDTYINASHIKFDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEpQTDEAIE
 .. ||||| ..| .  ...|.|  .  | |  ||.||   |   || . | . .. .|
nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlle.dvelkle
subfamily_CG42327_pd Subfamily CG42327 161-217 8.7e-07 22.9 In-house 49-106 (319) alignment 
Range on Protein: 161-217
Range on HMM: 49-106/319.0
NSRTDPPDTYINASHIK-FDNSQKEFIVTQYPLPDTVRDFWRMVSIMKVTQIVTIFEP
.   |. | |..||... .|...  .| .| .| |.  ||||.|   .   ||.. ..
rigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdl
0048076 (Phosphotyrosine protein) phosphatases II 326-432 1e-06 24.0 In-house 46-139 (145) alignment 
Range on Protein: 326-432
Range on HMM: 46-139/145.0
FAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTslianleKlAPIVVMCDLGLDRSATVVLTSIIIDqiiagKTPDCDALFKKMRDQRAGVFTMSIFY
.   | .. ||    ||. . .|.....  .  .        .  |..| |  |..|..|.|.  ...      .  . .  ....| || |...   ..
lgiqylylpwpDhgvpdllellleflefieealke.......g.gpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgql

TYAIRAA
 . ... 
rflyefe
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 277-428 1.1e-06 23.0 In-house 96-233 (239) alignment 
Range on Protein: 277-428
Range on HMM: 96-233/239.0
SFFPLETDHYMNLKGWLINTRrVTVDHRNKgwmnKYTveVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDtstSlianLEKLAPIVVMC
 ..|  | .| ||.  | .|  |  |.  .     .   .   | .|  .   |  | || |  |.    || | |   ||   |    |    | |. |
qywpdstskycnlrvtlrkte.vfadyiir....tfv..msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...s....lpgarpwvihc

DLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYA
  |. |. ....   .. |    || |     | .|..|  .   |  | . 
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 277-428 1.1e-06 23.0 In-house 95-232 (239) alignment 
Range on Protein: 277-428
Range on HMM: 95-232/239.0
SFFPLETDHYMNLKGWLINTRrVTVDHRNKgwmnKYTveVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKDtstSlianLEKLAPIVVMC
 ..|  | .| ||.  | .|  |  |.  .     .   .   | .|  .   |  | || |  |.    || | |   ||   |    |    | |. |
qywpdstskycnlrvtlrkte.vfadyiir....tfv..msqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...s....lpgarpwvihc

DLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYA
  |. |. ....   .. |    || |     | .|..|  .   |  | . 
sagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfi
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 330-431 1.3e-06 22.2 In-house 179-274 (439) alignment 
Range on Protein: 330-431
Range on HMM: 179-274/439.0
YNCTTWPWKKYPDDEKKVLALVRAPYKdtstslIANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAI
.  ..|| |. | .   || ..||           . |.  |.|| |  |. |. |..   | ..|. . .  | . . | .|.||  .      | .  
fhyiawpdknvpaqashvldflrains......andkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiy

RA
 |
na
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 327-436 2.1e-06 22.0 In-house 180-283 (319) alignment 
Range on Protein: 327-436
Range on HMM: 180-283/319.0
AKVYNCTTWPWKKYPDDEKKVLALVRAPYKDTSTslianlEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYT
 | .  | || .. |.. . .|.|..   | ..       ..  |||| |  |  |  | .  .......    . |     ...| ||  .      |.
vkhfqyteWpdhdvPekatslldllkrirksrek......tqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYk

YAIRAALFYM
.   | | ..
fiyealleav
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 298-428 2.4e-06 21.7 In-house 147-271 (315) alignment 
Range on Protein: 298-428
Range on HMM: 147-271/315.0
RVTVDHRNKGWMNKYTVEVVaEGCSEATFAKVY--NCTTWPWKKYPDDEKKVLALVRAPYKDTSTSLianleklAPIVVMCDLGLDRSATVVLTSIIIDQ
..|| ....   ..|||  .    ..    .|.  . |.||  . |     .. |.|   .   .|        ..||| |. |  |. | .  . ..||
kitvtrkseevnteytvrtl.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.......gaivvhcsaGvGrtGtfitldavldq

IIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYA
. | .  |   . ...|..| ..  .   | . 
aeaenaidvynfitgvrqnrikmvqvaeqyqfi
subfamily_PTPRA_pd Subfamily PTPRA 312-436 2.7e-06 21.5 In-house 176-295 (330) alignment 
Range on Protein: 312-436
Range on HMM: 176-295/330.0
YTVEVVAEGCSE--ATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKdtstsliANLEKLAPIVVMCDLGLDRSATVVLTSIIIDQIIAGKTPDCDALFK
. |. ..... |  .   . .  |.||    | . . .| |...  |        |  .  |||| |  |  |. | .  . ..... | .  |     |
flvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk.......lnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvk

KMRDQRAGVFTMSIFYTYAIRAALFYM
..| ||. .      |..  .. | | 
rlrlqrpqmvqtdeqyefiykvlleyy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 271-436 3.4e-06 21.3 In-house 66-221 (255) alignment 
Range on Protein: 271-436
Range on HMM: 66-221/255.0
SNVHRSSFFPLETDHYMNLKGWLINTRRvtvdHRNKGWMNKYTVEVVAEGCSEATFAKVYNCTTWPWKKYPDDEKKVLALVRAPYKdtSTslianlekla
. .. ||.|||| |  . |.   . | .      ..  .   ..        ..   | |. . |. |. |.. . .| ....  .  |           
gvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrd..sk..........

PIVVMCDLGLDRSATVVLTSIIIDQ----IIAGKTPDCD--ALFKKMRDQRAGVFTMSIFYTYAIRAALFYM
..||.|. |  |||. ||. ..  .    .   .| . |   | ...| .|..     .  ...|   | ..
svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 278-433 4.8e-06 20.4 In-house 139-280 (290) alignment 
Range on Protein: 278-433
Range on HMM: 139-280/290.0
FFPLETDHYMNLKGWLINTRRVTvDHRNKGWMNKYTVEVVAEGCSeaTFAKVYNCTTWPWKKYPDDEkkvLALVRAPYKDTSTSlianleklAPIVVMCD
..| .  . . .  . .     . |. ..  ..  .|  . .| .     | ..  .|| |  .  .   |||.|  .    .|         |.|| | 
yypekeGevltfGeitvlcseed.dkdaniikktlsvrdkdsGke..hklkhlkikswpdksvalst...lallrtlrilrkas........Gpvvvhcs

LGLDRSATVVLTSIIIDQIIAGKTPDCDALFKKMRDQRAGVFTMSIFYTYAIRAAL
 |. |. | |   . .. .. ||  |   | . .|. |..   . | |   ... |
aGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveill
0048179 (Phosphotyrosine protein) phosphatases II 328-427 9.8e-06 20.9 In-house 50-136 (144) alignment 
Range on Protein: 328-427
Range on HMM: 50-136/144.0
KVYNCTTWPWKKYPDDEKKVLALVRAPYKDtstslianLEKLAPIVVMCDLGLDRSATVVLTSIIIdqiiAGKtPDCDALFKKMRDQRAGVFTMSIFYTY
  | .. ||    ||. . .|.....  .         ||.  |..| |  |..|..|.|.  ...      .  . .  .. .| .| |...   .. .
iqylhlpwpDhgvpdllellleflefieea........leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrf