Gene K07F5.8 in Caenorhabditis elegans

Synonym: CELE_K07F5.8, K07F5.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf18
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP118_AA protein Get Run
CeleP118_AA_7-259 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1-276 1.4e-175 577.3 In-house 31-305 (305) alignment 
Range on Protein: 1-276
Range on HMM: 31-305/305.0
MKRFNDFSKMKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKC
||||||| ||||||.|||.|||||||||||||||||| |.|||||||||||||||||||||||||||||||||||.|||||.||.||||||..|||||||
mkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkc

HEYLPTEDnKDTMSFKEKGQKVTVKFESSKAIKFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAG
.||....| ||...|.|||||..||||||...|||....||||.|||..||.|....||.|||||||||||||.||.||||||||||.|||||.||||||
leyfaskd.kdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsag

IGRTGSVVMLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDEATSAIHKDFT
||||||||||||..|||||||||||||||.||||||||||.|||.||||||||..|.|.|..||||......|.|.
igrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldeevkeaykafl
0050432 (Phosphotyrosine protein) phosphatases II 8-260 3.8e-75 248.4 In-house 58-301 (308) alignment 
Range on Protein: 8-260
Range on HMM: 58-301/308.0
SKMKAFKDAQEHGKNRYKDVGCLDNNRVKLggAWPHEYIHANYVSTP--TNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLP
 ......  . . ||||||. ..|..||||    .. ||.|.||...   .|..||.||.||..|..||| |. . .|..| ||..  |.| .||..| |
leysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwp

TEDNKDTMSFKekgqKVTVKFESSKAikfrdNSAAKVTKTVLTVEGAGcDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS--KGPIAVHCSAGIGR
.| ..... ..    |.||.. | .      ..  .|..  ||  | | . ..|.|.|...||| |||.  ...|..||..| |  .|||.||||||.||
lelgggsleyg....kftvtllseev.....lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGR

TGSVVMLEYVMDQLLAGqIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
|| ...|.....|| ..    |  ....|.||||...|||  ||||...... ....
tGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
0040438 (Phosphotyrosine protein) phosphatases II 12-270 6.3e-74 244.4 In-house 37-288 (317) alignment 
Range on Protein: 12-270
Range on HMM: 37-288/317.0
AFKDAQEHGKNRYKDVGCLDNNRVKLGGAW---PHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTed
 ..  . ..||||.|. ..|..||||       .. ||.|.||..|  ...||.||.||..|..||| |. . .|..| ||.. .|.| .||..| |.  
vaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..

nKDTMSFkekgQKVTVKFESSKAikfrdnsAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAGIGR
 ..|. .     ..||.. | .         | .| ..|.||.  . ....|.|.|...||| |||   . .|..||..| .    .||..||||||.||
.getlty....gdftvtllseee.......lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgR

TGSVVMLEYVMDQLLAGQiIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDEATSA
||..........||  ..   | .......||||...|||  || |......... ... | .|.. 
tGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
0036941 (Phosphotyrosine protein) phosphatases II 11-263 1.5e-73 243.0 In-house 32-282 (297) alignment 
Range on Protein: 11-263
Range on HMM: 32-282/297.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLgGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNK
....  .   ||||||. ..|..|||| .  .. ||.|.||...  ...||.||.||..|..||| |... .|..| ||... |.| .||..| |.| ..
svallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleege

DTMSfkekgQKVTVKFESSKAIkfrdnSAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV------SKGPIAVHCSAGIGR
          ..||.. | . .       . .| ..|.|.   . ....|.|.|...||| |||.  . .|...|..|       |.||. ||||||.||
slty.....gdftvtllsvevv.....llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

TGSVVMLEYVMDQLLA--GQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGL
.|..........||     .   |  ....|.||||...|||  ||.|......... |. .
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0046845 (Phosphotyrosine protein) phosphatases II 9-260 6.3e-73 240.9 In-house 19-276 (284) alignment 
Range on Protein: 9-260
Range on HMM: 19-276/284.0
KMKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWP----HEYIHANYVSTP-----TNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKK
......  . . ||||||. ..|..||||    .    ..||.|.||...      ..|.||.||.||..|..||| |... .|..| ||..  |.| .|
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

CHEYLPTEdnKDTMSFkekgQKVTVKFESSKAikfrdNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS------KGPI
|. | |.|  .... .     ..||.. | .      ..  .|..  || .| .   ..|.|.|...|||.|||.  . .||.|...| .      .|||
caqYwple..gevlty....gdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpi

AVHCSAGIGRTGSVVMLEYVMDQLLAGQI--IEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
.||||||.|||| ...|.....|| ....    |  ......||||...|||  ||.||........ .
vVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 10-281 9.8e-73 239.8 In-house 35-300 (307) alignment 
Range on Protein: 10-281
Range on HMM: 35-300/307.0
MKAFKDAQEhgKNRYKDVGCLDNNRVKL--GGAwPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTE
..||.  ..  ||||.|| | |..|. .   |.   .||||||. . ..||.|||.| |||.|  .|| |..|..||.. |||.  | .  ||..| | |
veafsantd..knryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

DNKdTMSFKEKGQKVTVKFESSKAIKfRDNSAAKVTKtvLTVEGAGCdKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSV
. . .. | |... ..|.   .| .   |.   .||.  | |. |.     ..|. | .|||||||  . . ..|||  |  . |. ||||||.||.|..
egq.klvfgeapntisvanlgakkla.pdedlinvtt..lkvdwaqk.srtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGti

VMLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDEATSAIHKDFTDQYSK
| . .|.|...||.   | .|.....|.||. ..||. |||..|.|....| ..     .   . |.. ..|.|
vaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketyeellltknyeekyak
DSPc_SM00195 9-258 4.1e-72 238.0 In-house 17-262 (263) alignment 
Range on Protein: 9-258
Range on HMM: 17-262/263.0
KMKAFKDAQEHGKNRYKDVGCLDNNRVKLGGA---WPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLP
...  .  ... |||||.. . |..||||       ...||.|||.......|..|.||.||..|..||| |... .|..| ||.. .|.| .||..| |
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

TEDnKDTMSFKekgqKVTVKFESSKAIKfrdnsaAKVTKTVLTVEGAGC-DKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAG
 |  .... |.    |..||. . .  |      .......|...  |. .. ||..|.. .|||.|||   . .||||.... |    .||| ||||||
ees.ggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

IGRTGSVVMLEYVMDQLLAGQIiEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
.||||..|........| ...   | ..|....|.|| ..|||. ||||.........
vgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 9-258 4.1e-72 238.0 In-house 17-262 (263) alignment 
Range on Protein: 9-258
Range on HMM: 17-262/263.0
KMKAFKDAQEHGKNRYKDVGCLDNNRVKLGGA---WPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLP
...  .  ... |||||.. . |..||||       ...||.|||.......|..|.||.||..|..||| |... .|..| ||.. .|.| .||..| |
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

TEDnKDTMSFKekgqKVTVKFESSKAIKfrdnsaAKVTKTVLTVEGAGC-DKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAG
 |  .... |.    |..||. . .  |      .......|...  |. .. ||..|.. .|||.|||   . .||||.... |    .||| ||||||
ees.ggketfg....kisvklvevekkk......deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaG

IGRTGSVVMLEYVMDQLLAGQIiEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
.||||..|........| ...   | ..|....|.|| ..|||. ||||.........
vgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0051299 (Phosphotyrosine protein) phosphatases II 9-258 8.4e-72 237.4 In-house 40-286 (288) alignment 
Range on Protein: 9-258
Range on HMM: 40-286/288.0
KMKAFKDAQEHGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLP
...|..  . . ||||.|. ..|..||||    |  .. ||.|.|.... ....||.||.||..|..||| |. . .|..| ||..  |.| .||. | |
tlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwp

TednKDTMSFKEkgqkVTVKFESSKAikfrdnsAAKVTKTVLTVEG-----AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVH
.   .... ...    .||.. | .         ...|...|.|.       .  ...|.|.|...||| |||.  ...|..|...| .    .||..||
l...ggsltygd....itvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVH

CSAGIGRTGSVVMLEYVMDQLLAGqIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
||||.|||| ...|.....||...    |  ......||||...|||  ||.||..... ..
CsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 8-258 2.4e-71 235.7 In-house 28-272 (273) alignment 
Range on Protein: 8-258
Range on HMM: 28-272/273.0
SKMKAFKDAQEHGKNRYKDVGCLDNNRVKLgGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTE
 ......  . . ||||||. ..|..|||| |  .. ||.|.||...  ...||.||.||..|..||| |. . .|..| ||..  |.| .||. | |.|
ltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple

DNKDTMSFKEkgqkVTVKFESSKAikfrdnsAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV------SKGPIAVHCSAG
 .. .. ...    .||.. | .         . .|...|...     ....|.|.|. .||| |||.  . .||..|..|       |.||..||||||
ggelsltygk....ftvtllseet.......kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaG

IGRTGSVVMLEYVMDQLLAGqIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
.||||....|....||| ..    | .......|.|| ..|||  ||.|.........
vgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 20-256 8.2e-71 233.5 Pfam-A 3-235 (235) alignment 
Range on Protein: 20-256
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKdTMSFKEk
 ||||||. . |..|||| |   |..||.||||.. ...|.||.||.||..|..||| |..| .|..|.||.. .||| .||..| |.|... ...... 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygd.

gQKVTVKfesskaI-KFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSK----GPIAVHCSAGIGRTGSVVMLEYV
  ||..|        . .|...  ..|. |. ...  .| .|...|. .|||.|||.  ...|.|..| . ||    ||. ||||||.||||..|.|...
.ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

MDQLLAGQIiEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
..|| |..   |  .|....|.||...||. .|| |.......
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 20-256 8.2e-71 233.5 In-house 3-235 (235) alignment 
Range on Protein: 20-256
Range on HMM: 3-235/235.0
GKNRYKDVGCLDNNRVKL-GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKdTMSFKEk
 ||||||. . |..|||| |   |..||.||||.. ...|.||.||.||..|..||| |..| .|..|.||.. .||| .||..| |.|... ...... 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeee.sltygd.

gQKVTVKfesskaI-KFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSK----GPIAVHCSAGIGRTGSVVMLEYV
  ||..|        . .|...  ..|. |. ...  .| .|...|. .|||.|||.  ...|.|..| . ||    ||. ||||||.||||..|.|...
.ikvelk......ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldil

MDQLLAGQIiEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
..|| |..   |  .|....|.||...||. .|| |.......
leqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
0045450 (Phosphotyrosine protein) phosphatases II 9-259 4.8e-70 232.0 In-house 46-305 (307) alignment 
Range on Protein: 9-259
Range on HMM: 46-305/307.0
KMKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWP----HEYIHANYV--------STPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKG
......  . . ||||||. ..|..||||    .    . ||.|.||        ... ....||.||.||..|..||| |. . .|..| ||.. .|.|
eysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelg

AKKCHEYLPTEdnKDTMSFKEkgqkVTVKFESSKAikfrdnsAAKVTKTVLTVEG--AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV------
 .||..| |.|  .... ...    .||.. | .         ...| ..|.|.        ..|.|.|...||| |||.  . .|...|..|       
rekcaqywPde..geeltygn....ftvtllseeh.......ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelp

SKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQII--EDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
..||..||||||.||||..... ....|| .....   | .......|||| ..||. .|| |...... .. 
kggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 19-260 1.5e-69 229.0 In-house 56-291 (305) alignment 
Range on Protein: 19-260
Range on HMM: 56-291/305.0
HGKNRYKDVGCLDNNRVKLGGAWPHEYIHANYVSTPTNP-KRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDtMSFke
  ||||.|| | |.. |||    | .|||||||  |  | |||||.| ||..|  .||.| .|..|| | |||.  | |  || .| |.   .  ...  
itknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek.lel..

KGQKVTVKFESSKAIKfRDnsaAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQL
|.  |  .   || .. ||   |..  |.| .  .| .|. | | .| .||||||| .  . ||||   | || || |||||||||||..| .||.....
ksgivvenvsgskpme.rd...aeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyileki

LAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
   .      .... .|.||  |.|.| ||||.|.||.|.| .
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
0039614 (Phosphotyrosine protein) phosphatases II 14-259 3e-68 225.8 In-house 52-290 (297) alignment 
Range on Protein: 14-259
Range on HMM: 52-290/297.0
KDAQEHGKNRYKDVGCLDNNRVKLGGAWP----HEYIHANYVSTPTN-PKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAkKCHEYLPTED
.  .   ||||||. ..|..|||| .       . ||.|.||...   ...||.||.||..|..||| |. . .|..| ||.. .|.|  ||..| |.| 
llpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeg

NkdtmsfkeKGQKVTVKFESSKAikfrdnsAAKVTKTVLTVEGAGCDkLKVNHYHWIDWPDRGVPTADNAILELLEKARV------SKGPIAVHCSAGIG
.        .  ..||.. . .         . .| ..|.|.  |.  ..|.|.....||| |||   . .||.||..|       ..||..||||||.|
g........tygdftvtllkveh.......ldgytvrtlevtnnges.rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvg

RTGSVVMLEYVMDQLLAGqIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
|||..... ....||  .    | .......||||...|||..|| |...... .. 
RtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellk
0043336 (Phosphotyrosine protein) phosphatases II 10-257 1.7e-67 223.2 In-house 37-276 (278) alignment 
Range on Protein: 10-257
Range on HMM: 37-276/278.0
MKAFKDAQEHGKNRYKDVGCLDNNRVKLGG---AWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPt
.. ..  . . ||||||. ..|..||||      ... ||.|.||...  |..||.||.||..|..||| |. . .|.|| ||.. .|.| .||..| | 
ysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.

ednKDTMSFKEkgqkVTVKFESSKAikfrdnsAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV----SKGPIAVHCSAGI
   .... ...    .||.. . .         . .| ..|.|.      ...|.|||...||| |||.  . .|..|...|     |.||..||||||.
...ggsltygd....ftvtllkeeh.......lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGv

GRTGSVVMLEYVMDQLLAGQiIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNF
|||| ...|.....||  ..   | .......|||| ..|||. || |...... .
gRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealley
0040439 (Phosphotyrosine protein) phosphatases II 14-258 1.3e-66 220.1 In-house 7-246 (249) alignment 
Range on Protein: 14-258
Range on HMM: 7-246/249.0
KDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTednK
.    . ||||.|. ..|..||||   .| ... ||.|.|....  ..|||.||.||..|..||| |. . ....| ||.. .|.| .||..| |.   .
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl...g

DTMSFkekgQKVTVKFESSKAikfrdnsAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV------SKGPIAVHCSAGIGR
... .     ..||.. | .         ...| ..|...     ....|.|....|||| |||   . .|...|..|       ..||..||||||.||
gsley....gdftvtllsvev.......kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgR

TGSVVMLEYVMDQLLAGQIiEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
|| .... ....||   .   | . .....|.||...||...|| |...... ..
tGtfiaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 19-260 8.9e-66 217.4 In-house 34-274 (278) alignment 
Range on Protein: 19-260
Range on HMM: 34-274/278.0
HGKNRYKDVGCLDNNRVKlggawphEYIHANYVSTPtnPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPtEdnKDTMSFkek
  ||||||. ..|..|||       .||.|.|....  ||.||.||.||..|.|||| |. . ....| ||.. .|.| .||..| | |  .... .   
ldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e..ggslty...

gQKVTVKFESSKAIkfRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTAD--NAILELLEKARV-----------------SKGPIAVHCSA
  ..||...| . .   |    . . | |||| ... ...|.|.|.. ||| |||. .  . .|||||  |                  |.||..|||||
.gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GIGRTGSVVMLEYVMDQLlagQIIEDTDKIIQKIREQRNN-SVQTDHQYLFVHQVMMNFFEK
|.|||| .|.. .....|   .   | .......|.||.. .||. .|| |...... ....
GvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
0042113 (Phosphotyrosine protein) phosphatases II 16-259 2.8e-64 212.2 In-house 7-244 (245) alignment 
Range on Protein: 16-259
Range on HMM: 7-244/245.0
AQEHGKNRYKDVGCLDNNRVKLGGAWP---HEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTednKDT
   . ||||.|. ..|..||||    .   . ||.|.||...  ...||.||.||..|..||| |. . ...||.||..  |.| .||..| |.   ...
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl...ges

MSFKEkgqkVTVKFESSKAikfrdnsAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV-----SKGPIAVHCSAGIGRTGS
. ...    .||.. | .         ...| ..|.|.      ...|.|||...||| |||. .. .|..|| .|      |.||..||||||.|||| 
ltygd....ftvtllseeh.......lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

VVMLEYVMDQLLAGQiIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
.... ....|| . .   . .......|.|| ..|||..|| |..........
fiaaylmleqlekel.gvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPRD_pd Subfamily PTPRD 13-259 6.1e-61 201.7 In-house 43-282 (564) alignment 
Range on Protein: 13-259
Range on HMM: 43-282/564.0
FKDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEdN
 .  .   ||||...   |..||.|    |    .|| |... . ...| .| ||.||..|..||| |. . ...|| || . .||| .|||.| |.. .
ankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g

KDTMsfkekgQKVTVKFESSKAIKFRDNSAAKVTKTVltvegaGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAGIGRTG
. |.      ...||..|... ..       |..|.         .. .|...|...|||.|||.  ...|.|..| | .    .||| ||||||.||||
tety......geltVtleeeeeladyeirtfklkkkk......ssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTG

SVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
  . ........ . . . |  ......|.|||  ||| .|| |.|...... .
tfividamlerikeektv.DiyqyvkalrkqRnamVqteeQYiFiheaileala
0037934 (Phosphotyrosine protein) phosphatases II 16-257 7.9e-61 201.0 In-house 8-241 (243) alignment 
Range on Protein: 16-257
Range on HMM: 8-241/243.0
AQEHGKNRYKDVGCLDNNRVKLGGawpHEYIHANYVSTPtnpKRFICTQAPLEKTCAD----FWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPtednkD
 . . ||||.|. ..|..||||.|   . ||.||..  .   .|.|.||.||..|..|    || |. . ....| ||.. .|.|..||..| |     .
penlsknrysdilpydhsrvkleg...sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.....g

TMSFKEkgqkVTVKFESSKAikfrdnsAAKVTKTVLTVEG--AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKAR------------VSKGPIAVHC
.. ...    .||.. |..         ...| ..|..|   ..  .. | |||.. ||| |||.  . .|..|...|             |.||..|||
evtygd....ftvtllseeh.......lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SAGIGRTGSVVMLEYVMDQLlaGqiiEDTDKIIQKIREQRNN-SVQTDHQYLFVHQVMMNF
|||.|||| .... .....|  |    | .......||||.. .||| .|| |...... .
saGvgRtGtliaaylmllll..g...vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 11-259 2.2e-59 195.5 In-house 49-284 (290) alignment 
Range on Protein: 11-259
Range on HMM: 49-284/290.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWPHEYIHANYVSTpTNPkRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEdNK
| |    |  ||||||| | |  || |    . .|.|||||   ...  || || .|..|  |.| | ||..| .| |||.  |.|  ||..| | . . 
kifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkG.lka.mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypek.eG

DTMSFKEkgqkVTVKFESSKAikfRDNSAAKVTKTVLTVEGAgcDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVML
....| |    .||    ..    .|.   | | .|  ..     . |..|.. . |||. |. .. |.| .|   |   ||..|||||||||||. | .
evltfGe....itvlcseedd...kdaniikktlsvrdkdsG..kehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvai

EYVMDQLLAGQIIEDTDkIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
|  .. || |. ..  | ... .|. | |||| | ||| . ......  
evglqilldGkeldlld.lvralrnsrlnsvqvdiqylalveilldlGk
subfamily_PTPN12_pd Subfamily PTPN12 12-260 7.1e-57 187.5 In-house 34-279 (290) alignment 
Range on Protein: 12-260
Range on HMM: 34-279/290.0
AFKDAQEHGKNRYKDVGCLDNNRVKLGGAWPHE---YIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTED
| .  ..  ||||||.   |..||.|     .|   || ||..  .......| .|.|| ||  ||| |  . .|| . |.|.  | | |||. | | | 
agekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeeg

NKdTMSFKEkgqkVTVKFESSKAIKfrDNsaakVTKTVLTVEGAgCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAGIGRT
.. .. | |    ..|. |. ||..  |.     .   |.||    .. ||. .|. .|||.|||.. . .|||.|..|      . |..||||||.|||
ee.elefge....fevtleeekavd..dd....flirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

GSVVMLEYVMDQLLAGQIIEDTD--KIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
| .. ..|| ..| |..| |. |  ......|.||.  |||  || .|.. ......|
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_PTPRB_pd Subfamily PTPRB 8-261 9.3e-57 187.3 In-house 41-288 (293) alignment 
Range on Protein: 8-261
Range on HMM: 41-288/293.0
SKMKAFKDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYL
 ..|| . |... ||||...   |..||||    .    .|| |||..  . |. || || || .|  ||| |........| || .  ||| .||.|| 
qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYW

PTEdnkdtmsfkekgqKVTVKFESSKAIKFRDNSAAKVTKTVLTVEGaGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKAR------VSKGPIAVHCS
|..             . .| . . |     ...  . .   |..|  . .. ||..||.. ||| ||| . ...|..... |       ||.|| ||||
Pad.............eepvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCs

AGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKR
||.||||  . |. .....   ... |   |....||.||. ||| .||.|.||.......|.
aGvGRtGtfialdrllqaieeedyv.difgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 11-263 3.1e-54 179.0 In-house 40-284 (288) alignment 
Range on Protein: 11-263
Range on HMM: 40-284/288.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLGG---AWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTE
.| . |. . ||||...  .| .|||| .       .|| |.|.    . |..|.||.|| .|  ||| .  .....|| || .  |.| .||.|| |..
tagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda

DNKDTMsfkekGqKVTVKFESSKAIKfrdnsaAKVTKTVLTVegAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAGIGR
|..        | .|||.  .||  .        |....| .     ..|....|..  ||| ||| . . .||||..  |.     ||| ||||||.||
dkpkny.....G.svtvtlveskele......dfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGr

TGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGL
||  . |. ..|.. . . | |   ...|.|.||.. ||| .|| |...|...  |..|.
tgtFialdalidaveeedyi.DvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_PTPN3_pd Subfamily PTPN3 7-260 2.2e-53 176.0 In-house 30-277 (280) alignment 
Range on Protein: 7-260
Range on HMM: 30-277/280.0
FSKMKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWPhEYIHANYVSTPTNP----KRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHE
  ...| . ...  ||||.|.   |. ||||  .   .|| ||||.   .     .|.| || ||.||..||| |  ......| || .  |.| .|||.
glaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChq

YLPTedNKDTMSFKekgqKVTVKFESSkaikfrDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV----SKGPIAVHCS
| |.  ..|....     . .|| |..      |.. . |.. ..  . .  .. |. .  ...||| |||.  . .||..|. |     .. |. ||||
yWPe..tedeleyg....efsvkceke......detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCs

AGIGRTGSVVMLEYVMDQLLAGQIIEDTDkIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
||||||| ...||  .  . | . .   | |....|.|| . ||| .|| || . ... .|.
aGigrtGvlilletalalieaaepvypld.ivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 12-267 9.5e-53 173.7 In-house 48-297 (310) alignment 
Range on Protein: 12-267
Range on HMM: 48-297/310.0
AFKdaQEHGKNRYKDVGCLDNNRVKLG--GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDN
|.|  ..  |||| || |||. ||||    .  ..||||||| |    . |||.| ||..|  ||| | .|.| |.|..||.  |.|  ||  | |.   
ayk..kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

KDTMSfkekGQKVTVKFESSKAIKFRDNSAAKVTKTVLTVE-GAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVV
 .|        .||   |||. ..  . . . |   |   |  |  ..|.|.  .| .|||||||      .     |.| .||  ||||||..|.. ||
tetyg....cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvv

MLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFekRGLLDEA
 |.. .|.|  |. . |..... ... .|   .||. |||....|.. |   ||  . |
alklkidkldrglkv.daeevktellksraiciqtelqyliidrvriifa..rgeteva
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 10-258 3.1e-52 172.7 In-house 48-290 (298) alignment 
Range on Protein: 10-258
Range on HMM: 48-290/298.0
MKAFKDAQEHGKNRYKDVGCLDNNRVKLGG---AWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPT
... .  . . |||| |.  ||  || |         .|| | .... .. . || |||||..| .||| |  .. ..|| || | .|..  |.|.| |.
kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPd

EDnkdtmsfKEKGQKVTVkfesskaIKFRDNSAAKVTKTVLTVEGAG-CDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSK---G--PIAVHCSAG
|        ||.  ..||          .... |..... |.|. .   .. .| . |.. |||.|||.  ...|.||.| | |.   |  |. |.||||
eg.......ketygeitv.......sllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaG

IGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
.||.|. . .. |.... . | . |  .... .|..| ..||| .|| |.........
vgRsGtfiaidsvlervkkeqvv.DvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN13_pd Subfamily PTPN13 10-258 4.4e-52 172.0 In-house 29-269 (273) alignment 
Range on Protein: 10-258
Range on HMM: 29-269/273.0
MKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWPheYIHANYVSTPTNPKRF--ICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTE
 .  |..... ||||..|   |. |||||.  .  || |...  | . ...  | .| || .|..||| |  . ..| | |. . ||||  ||| | | .
cevgkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

DNKDTMSfkekGQKVTVKFESSKaikfrDNSaAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV---SKGPIAVHCSAGIGRT
 || ..      ....|. .  .     . . . | ...   . .  .  .| | ....||| |||.. . .|... . |    ..|||.|||||||||.
knkklkv....snrlevellkvq.....kld.gfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrs

GSVVMLEYVMDQLLAGQiIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
|... .. |.. .   .   |  .|..|.||||.  |||. ||.||...... .
Gtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 15-256 5.4e-52 171.8 In-house 43-281 (305) alignment 
Range on Protein: 15-256
Range on HMM: 43-281/305.0
DAQEHGKNRYKDVGCLDNNRVKLGGAWPH---EYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKD
. ... |||.|..  ||..|..|     .   .|| |.|| .  . |..| .|.||..| |||| . .. .|.|| ||.. .| | .||. | |.. ...
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktek

tMSFkekgQKVTVKFESSKAIkfRDNSAAkvtKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKA----RVSKG-PIAVHCSAGIGRTGS
 . |    ....|. .|.|..   |       |  ...|    ..  | .|.  |||| |||.   ..|.|...     . .|| |. ||||||.|||| 
.kef....gefsvelksekta..sdyieR...klkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

VVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
 ....  ...| . ... |  ......|..| . |||  || |.|... .
fiavdialerlkkEevv.dvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 11-260 3.8e-51 168.9 In-house 34-278 (281) alignment 
Range on Protein: 11-260
Range on HMM: 34-278/281.0
KAFKDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPtE
.| |  .   ||||...   |. |||.     .   .|| ||.|.. ...|..| ||.|. .....|| | .. .|..| |. .  |.|  ||| | | .
taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.d

DNKdtmsfkekgqkvTVKFESSKAIKFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKA---RV--SKGPIAVHCSAGIG
||.            ..|.   .  . . .. |.  . ....|  .... .|.. ... ||| |||.  ...||  ..    .   .| |. .|||||.|
dns............elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvG

RTGSVVMLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
|||. . |. ..... | .   | . .....|..||  |||  || ||...... ..|
rtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 12-259 6.8e-51 168.2 In-house 42-284 (319) alignment 
Range on Protein: 12-259
Range on HMM: 42-284/319.0
AFKDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTED
  .  . . ||||...   |. ||.|    |    .|| |... .  . ..|| ||||||.|  ||| |  .... .. ||.. .||.  |...| |.|.
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen

nkdtmsFKEKGqKVTVKFESSKAIKfrdnsAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV-----SKGPIAVHCSAGIGR
      |.| | ...|. |. .  .        . |  |    .  .  .| |... .||| .||.   ..|.||.. |      ..||| ||||||.||
......feeyG.rlivtleeeeele.....dyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGR

TGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
||. ..|. .....   ... |  ......| |||  ||. .|| |........ |
tGtfivldamlervkeegvl.DvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 19-251 2.1e-50 166.2 In-house 51-274 (301) alignment 
Range on Protein: 19-251
Range on HMM: 51-274/301.0
HGKNRYKDVGCLDNNRVKLGGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNkdtmsFKEK
. |.||. | |  .  |..        ||||...|. .|.|||.||.||..|. ||| |. |  ||.| ||..  ||  .||.||||.. .      | .
kdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkis.....ekld

GQKVTVKFESSKAIkFRDNsaakVTKTVLTVEGA--GCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQ
 .. ..| .... | ....    ..|  | || .    .   | || . .|.||||| .   . .|.| .. |. || |||||||||. . .  ||.  .
igrfkikiknkeli.lnkk....iskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylare

LLAGQIIEDTDkIIQKIREQRNNSVQTDHQYLFVH
..| . || |.  ....||.| |.||| .|  .. 
veadptielte.alkhlrehrwngvqtnsqlywmt
subfamily_PTPN6_pd Subfamily PTPN6 7-261 2.5e-50 166.2 In-house 44-300 (306) alignment 
Range on Protein: 7-261
Range on HMM: 44-300/306.0
FSKMKAFKdAQEHGKNRYKDVGCLDNNRVKL--GGAWPHEYIHANYVS--TPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHE
.|.... | .. . ||||| .   |..||.|   .   ..|| |||..  .... |..| ||  ||.| .||| | .|.  . | |. .  |.| .||  
lsrkegak.penkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCar

YLPTEDNKDTmsFkekGQkVTVKFESSKaikfrDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKA-----RVS---KGPIA
| |.| .|..  .   |. ..|.  |.|     .... .. . ... .  . .. .| .||. .||| |||.  .|.|..||.      ...   .||| 
YWPdeeekee..y...Gk.isvtnvsek.....sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpiv

VHCSAGIGRTGSVVMLEYVMDQLLAGQIIE--DTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKR
|||||||||||...... .....    .    |  |.....||||.  |||..|| ||.... .. |..
vhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 6-259 2.7e-50 166.2 In-house 35-281 (318) alignment 
Range on Protein: 6-259
Range on HMM: 35-281/318.0
DFSKMKAfKDAQEHGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHE
 ....|.  .   . |||| ..   |. ||||    |    .|| |||.   .. | .| .|||| .|. ||| |  .    .| || . .|.| .|.| 
tvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhr

YLPTEDnkdTMSFkekgQKVTVKFESSKAIkfRDnsaaKVTKTVlTVEGAG-CDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS-----KGPIAVH
| | ..   ..|.    .|..|. .... .   |     | ... .|.  .  .. .|  ||. .|||.|||.    .|.|. ...       .|||.||
yWPskg...srsy....gklvvelkeevel..sd....yvlref.kvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSAGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
||||.||||  .... ..... | ... |  ......|||||  |||..|| |...|.... .
CsaGvGrtGvfiavdillerikaealv.Dvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Ptp69D_pd Subfamily Ptp69D 16-261 3e-50 166.1 In-house 45-289 (307) alignment 
Range on Protein: 16-261
Range on HMM: 45-289/307.0
AQE-HGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEdnkD
 .|   ||||.|.   |..||||    |    .|| |... .  . |.||. |.|.| |  ||| |  .  |..| || | .||  |||. | | |   |
kkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie...d

TMSFKekgqKVTVKFESSKAIKFRDNSAAKVTKTVLTVeGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKA----RVSKGPIAVHCSAGIGRTGSV
.. .     .. ||. |..  .   . . .|.|.  .. |   |. ||  ||.  |.|  || . ...|.|.|..    . ...|| |||||| ||.| .
evqyg....dilvklvseekhsdyiiReldvskkkees.gevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgif

VMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKR
| |. ...|| | . . |  ......|.|||  ||  .|| |... .... .. 
valdsllqqlkaedkv.difetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 14-257 3.7e-50 165.5 In-house 5-241 (250) alignment 
Range on Protein: 14-257
Range on HMM: 5-241/250.0
KDAQEHGKNRYKDVGCLDNNRVKLGGAW---PHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKkCHEYLPTEDNK
|. |.. |||| |.  ||. || |         .|| | .. . .. | || ||.||..|  ||| | |.. ..|| || | ||.. . .|.|.|.|  .
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

dtmsfkEKGqKVTVKFESSKAikFrdnsaAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV-----SKGPIAVHCSAGIGRT
      . | .|||.  |..   |     | .||..| .      |.  | ..|.. |||.|||   .|.||||.| .       ..|. |.||||.||.
......kyG.dvtvsllskee..f.....adytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrs

GSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNF
|. . .. |...|   ... |  |.|...|..| ..|.. .|| ||.......
Gafiaidavlerlkkekvv.dvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 15-260 6.6e-50 164.6 In-house 17-266 (270) alignment 
Range on Protein: 15-260
Range on HMM: 17-266/270.0
DAQEHGKNRYKDVGCLDNNRVKLGG---AWPHEYIHANYVS-TPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTednk
 |...  |||.|.    . ||.|         .|| ||||     ..|..|....||. |  .|| | .. .|..| |. . .||| |||  | |.    
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa....

dtmsfkEKGQKVTVKFESSKAIKFRDNSAAKVTKTVLTVEgAGCDKLKVNHYHWIDWPDRGVPTADN------AILELLEKAR-----VSKG-PIAVHCS
      |...||....   | ..  .. .    .| |..|    .. .. |... .|||.|||....       .|..|.. |      .|. |. ||||
......epkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGIGRTGSVVMLEYVMdQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
||.|||| ...|.... .||  .   |. .||...|..| . ||. .|| |........ |.
aGvgRtGtlialDiav.rlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRG_pd Subfamily PTPRG 11-258 4e-49 162.3 In-house 40-287 (563) alignment 
Range on Protein: 11-258
Range on HMM: 40-287/563.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLGGAWP----HEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPT
.. .. ... |||| ..   |. |||| .       ..|| |||.      | || || ||..|. ||| |  . .|..| |. | .|.|..||. | |.
ehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk

EDNKDTmsfkekgQKVTVKFESSKAIKFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS----KGPIAVHCSAGIG
.. ..        ....|. .... .        .. .. |  .    ....| .||. .||| |||.     |   .|.  .     ||| ||||||.|
desety.......galqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvg

RTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
|||  ..|. .. |. . ... .  .....|| |||. |||  ||.|.|.....  
rtGtyivldtllkqiqqenav.nvfgflkhiraqRnflvqteEqYiflhdalleai
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 21-281 5.4e-49 161.6 In-house 46-298 (312) alignment 
Range on Protein: 21-281
Range on HMM: 46-298/312.0
KNRYKDVGCLDNNRVKLGGAWpHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLptednKDTMSFKEKGQ
 ||| .. | |  |  | |     |||||.|   |.|.||.|||.|||.||. || ..|     .| .|| . | |..|| .|.      | ..| .  .
lnrypniqcwdrgrftlagde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi.....sdivgfvdled

KvTVKFESSKAIKFRDNSAAKVTKTVLTV-EGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLA
.  |  |.   |.   .|  |.|. || |   |  .. |.||| |  ||| |.| . .. | ||   .  | |.  |||||.||||.....| ..  |  
h.rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrh

GQIIEdTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDEATSAiHKDFTDQYSK
 .  .   ..   .| .|  ||..  ||... .....|.  .||        .  | . |.|
prkqn.vkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqe.wtkfketyak
0051429 (Phosphotyrosine protein) phosphatases II 44-274 2.2e-48 160.6 In-house 5-241 (272) alignment 
Range on Protein: 44-274
Range on HMM: 5-241/272.0
EYIHANYVSTPTN---PKRFICTQAPLEKTCADFWFMcLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDTMSFKEKGQKVTVKFESSKAIKFRDNSAA
 ||.|..|.....   |.|......||. |.||||..  . .. ||..|..  |.|. ||. |.|  .      . .  . ... . . . ...   .  
gyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldy

KVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTadNAILELLEKARVsKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQIIED-------TDKIIQKI
 ... .|| .    . ..| |.|..||||.|||.  .|.|||||  .  .||. ||||||..||| ||.| ... .. . .|..|        .......
ilrellltlllsagearevmhlhytdwpdhgvpq..eallellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

REQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDEATSAIHKD
|.|| ..|||..||||...........    .... . . |
raqrpgavqteeqylflyeallellrsllsvraeyllaald
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 17-260 5.4e-48 158.4 In-house 27-270 (274) alignment 
Range on Protein: 17-260
Range on HMM: 27-270/274.0
QEHGKNRYKDVGCLDNNRVKLGGAWP----HEYIHANYVSTPT-NPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPtedNKD
 .. |||||..   .| || |  . .     .|| |||.  .  . | .. || || .| |||| |  |..|. | || . ||.  .||..| |   .. 
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP...dae

TMSFKEKGQKVTVKFESskAIKfRDNsaAKVTKTVLTVEGAgcdKLKVNHYHWIDWPDRGVPTADNAILELLEKAR-------VSKGPIAVHCSAGIGRT
 .  .|. ..| .|.|.  ... |..   .|.| ||        . .| || . ||||. .|   |..|.|... .          .|. ||||||||||
dyeiserygdveikvek..ive.rnd..ysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
|  .  .  . || . ... |  ||. ..| .|   |||..|| ..|.... . ..
Gcfiaisiavrqlreeivv.dvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPN23_pd Subfamily PTPN23 20-256 5.4e-48 158.3 In-house 45-278 (288) alignment 
Range on Protein: 20-256
Range on HMM: 45-278/288.0
GKNRYKDVGCLDNNRVKLGGAwPHEYIHANYVS--TPTNPKrFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDnKDTMSFKE
 |||..|.   |.||||| |    .|| | .|   .|. |. ||.|||||..| .||| |  ......| || . .|.| .|...| |..   .|..|..
eknrsrdilPyDhnRvklrgs.kDDYinAsfvkdlspgcPd.fiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedk.getvkfgd

kgqkVTVKFESSKaikfrdnSAAKVTKTVLTVEGAGCDK-LKVNHYHWIDWPDRGVPTADNAILELLEKARV--------SKGPIAVHCSAGIGRTGSVV
    ..|  .| .       .. .. . ||..|  . |.  .| | ..  ||. ||| . . .|..|....         || |. ||||||.|||| . 
....lsvtlksvr.......etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfa

MLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
..  .. .| .|... |. ......|||| ..||. .|. |. .....
lvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 17-256 4.4e-47 155.5 In-house 42-269 (288) alignment 
Range on Protein: 17-256
Range on HMM: 42-269/288.0
QEHGKNRYKDVGCLDNNRVKLGgAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNkDTMSFK
..  ..||... . |  ||||    |. ||.|| ||.  ...|.||.||||. |   .| | |.  || | |||.  ||| .|  ||.|..   ... ..
anptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklG.ekarig

EKgqkvtvkfesSKAIKFR-DNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMD
             . .| . ..    |. ..| ..  | .|  | . |. .|.| |||    . | |||  .  . || ||.|||.|||| ...   ...
rl..........ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililiale

QlLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
. |  .      ....| ||.| ...||  |||.||.....
s.lrlddflgirsllaklreerfkaiqtemqylyvhrcvle
subfamily_PTPRA_pd Subfamily PTPRA 15-259 2.5e-46 153.1 In-house 55-296 (330) alignment 
Range on Protein: 15-259
Range on HMM: 55-296/330.0
DAQEHGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDnkd
  ... |||. ..   | .|| |    |    .|| | ..    . ..|| .| |.|.|  ||| |  . .  || || . ||.  .||. | |.|    
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG...

TMSFKEkgqkVTVKFESSKAIkfRDNSaakVTKTVLTVEGAGC---DKLKVNHYHWIDWPDRGVPTADNAILELLEKAR----VSKGPIAVHCSAGIGRT
.... .    ..|. | .. .   | .   | | ...  . ..   ..  |. .|.  ||| |||.    .|.||.| .    .| ||| ||||||.|||
lvtyGn....irvevedetvl..vdyt...vrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrt

GSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
|. ..|. |.... | ... |  ......| || . |||| || |...|..... 
Gtfivldavlervkaerkv.dvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_PTPN1_pd Subfamily PTPN1 10-256 3.3e-46 152.3 In-house 24-269 (290) alignment 
Range on Protein: 10-256
Range on HMM: 24-269/290.0
MKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAwPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDN
... |. .....|||.||   |  |.||  |   .|| |. |  .   ...| || || .|.. || |  ...  .. || .  ||.  ||..| |....
treaklpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

KDTMSFKEKGQKVTVkfesskaikFRDNSAAKVTKTVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS------KGPIAVHCSAGIG
.... ...   ||..          . ..  . |  .| .|     .  .. |.|.. ||| ||| . .| |..| | | |      .||  .|||||||
ekellledtklkvkl.........iseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGSVVMLEYVMDQLLAGQI--IEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
|.|...... .. .. . .     |  | . ..|..|   .||  |  | .. ...
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0041856 (Phosphotyrosine protein) phosphatases II 20-258 5.5e-46 151.8 In-house 3-171 (182) alignment 
Range on Protein: 20-258
Range on HMM: 3-171/182.0
GKNRYKDVGCLDNNRvklggawPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCnykekgakkCHEYLPTEDnkdtmsfkekg
 ||||.|. . |..|       .  ||.||..  .  ..|||.||.|| .|.|||. |  . .. || .|.         .. | |..            
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell...........

qkvtvkfesskaikfrdnsaakvtktvltvegagcdKLKVNHYHWIDWPDRGVPTaDNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQlla
                                    .  . .|... ||| |||.  . .|...|... ..||..||||||.||||..|.. ... .   
....................................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl...

gQiiEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
 .   . ..... .|..|...|.| .|| |...... ..
.g..vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 12-257 9.4e-45 147.4 In-house 31-268 (281) alignment 
Range on Protein: 12-257
Range on HMM: 31-268/281.0
AFKDAQEHGKNRYKDVGCLDNNRVKLGGAWP----HEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTE
.|..  .  |||| .. |||  ||.|    |     .||||||. .|   . .| || | ..| |||| |  |.   .| |||.. |   .|| ||.| .
vfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprn

DnKDTMSFkekgQKVTVKFESSKAikfrdNSAAKVTKTVLTVEGAgcDKLkVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSV
  .  . |    .|..|..| |       | .   |.  |. ||    .| . |. | .|||  || . . .|..| | |    |  .|||||.||.|..
a.hcclqf....dklsvsyedstv.....nkslvttrlnlsyege..trl.ithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtl

VMLEYVMDQLLAGQIIEDTDKIIQKIRE-QRNNSVQTDHQYLFVHQVMMNF
. .|  .. . .   . |  .|. ..|   |  |||| .||... .|...|
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_PTPRK_pd Subfamily PTPRK 11-256 1.3e-43 144.1 In-house 36-275 (314) alignment 
Range on Protein: 11-256
Range on HMM: 36-275/314.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLGGAW---PHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPte
 | |. ... |||..|.   |. ||.|         .|| |... . ..|. || || ||..| .||| . ....  .| || . .|.|. || .| |  
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP..

dnKDTMSFKEkGQKVTVKFESSKAIKFRDNSAAKvtktvltVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV----SKGPIAVHCSAGIGR
  .||. ...  .   |. |  . .  |  .  |       .. .  .. .|...... ||| .||.  ...|.|. .       ..|.| |||||| ||
..edtevygd.ikvelvetellaelvvrifrvek.......largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGr

TGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
||  .... |.| .   ... |  ......|... | |.|  || |...|...
tGtfiaidivldmieregvv.dvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 18-260 4.3e-43 142.2 In-house 46-285 (290) alignment 
Range on Protein: 18-260
Range on HMM: 46-285/290.0
EHGKNRYKDVGCLDNNRVKLG---GA--WPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDT
.. .||....   |.||. |    |    ..|||.| |.    . |..| ||.|...| .||| .  |..|  | ||.| .|.| .||. | |..|.|. 
nkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkay

MSFKEKGqkvtvkfesskaikFRDNSAAKVTKTVLTVEGAGC--DKLKVNHYHWIDWPDRGVPTADNAILELLEKA-----RVSKGPIAVHCSAGIGRTG
  |. |                 ...  . ... | |.      .| .| .|.   |.. |  |. ..|| ..|.      .  ...| ||||...||..
gefsikl..............lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsa

SVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
  . ..  ...    . | |  ..... | |. .|||| .|| ...|.... ...
vfcaaattinkcktegvi.dvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 17-261 9.2e-43 141.1 In-house 42-279 (515) alignment 
Range on Protein: 17-261
Range on HMM: 42-279/515.0
QEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDnKDTm
 .. |||||..  .|..||||     .  ..|. | |. .  | | .|..|.|.. .  ||| . ||..| || |. . ||    || .| |     |. 
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp.gds.

sfkekgqkvtVKFESSKAIKFRDNSAAKVTKTVLTVEgAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKG----PIAVHCSAGIGRTGSVVM
          ||| | |      .. .  .|  |||   | |   |  .|. .|||.|||   ...| |. . . ..|    |. .|||||.|||| |. 
..........vkfGsikvelvsleactggikrkltvl.kgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

LEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKR
.. |. .   .... |  .....||..|   |||. || |....... .  |
idsvvahakttrmv.dvfnfvtnirqkrpylvqtqeqyafiygavledllwr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 8-263 3.9e-42 139.2 In-house 34-282 (315) alignment 
Range on Protein: 8-263
Range on HMM: 34-282/315.0
SKMKAFKDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYL
.. .. .. ... |||||..  ||..||||        ..|| | |. .  . | .|..|.||. .  ||| | ||..| || |. . .|    ||  | 
yrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PTEDnKDTMSFkekgqkvtvkfESSKAIKFRDNSAAKVTKTVLtVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKG----PIAVHCSAG
| ..  |.. |            | |   .  .. .  ..  | |   . .. .|  ... .|||.||.    ..|.|. . . ..|    .. ||||||
Pdrk.adsvef...........Gsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaG

IGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGL
.|||| |. .. |..|.  .. . |  ......|..|   |||. .| |....... .  |  
vGrtGvvisidevvaqikrtrsv.dvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 17-258 1.4e-41 137.4 In-house 46-278 (287) alignment 
Range on Protein: 17-258
Range on HMM: 46-278/287.0
QEHGKNRYKDVGCLDNNRVKLGGAwPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNkdtMSFK
| . |||....   ||.|| | |   ..|| | .. .  . |.|| ...|. .|  .|| .  . .|..| |||. ||.  ..|..| |.|..   ... 
qnkdknRltqilvpdnyrvllkge.hpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks...vvlG

EkgQKVTVKFESskaiKfrdNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRG-VPTADNAILELLEKA----RVSKGPIAVHCSAGIGRTGSVVMLE
|   ....  |     .   |.   . |  .. ..   ||..|. |.  .|...| |..    .| . |.     . ....| ||||...||..  .  .
e..yniellnee....v...nagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaa

YVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
  ...     .| |  ..... | |. .|||| .|| |. ...... 
ttinkckteGvi.Dvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_PTPN14_pd Subfamily PTPN14 11-259 6.5e-41 135.3 In-house 42-297 (300) alignment 
Range on Protein: 11-259
Range on HMM: 42-297/300.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLGGAW--PHEYIHANYVSTP--TNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPT
.. |  ..  |||.|||   ..|||.|  .    ..|| |  ....  .. . .| .|.|||.|. ||| |  .. |. | || . .|.| .|...|.| 
staklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk

ED-NKDTMSFKEkgQKVTVkfesskaiKFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKAR-------------VSKGP
.. .|.|. |..   |||         ||...| . .|...        .. .| |  ..||||.|||   .  |. ||. .              || |
leskkktvefgk..fkvtt........kfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

IAVHCSAGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
. ||||||.|||| ... . ..  |  .. | | .|.....||||   |||  || ||..|......
vlvhCsaGvGrtGvlilsdlliatlehneei.dikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0046846 (Phosphotyrosine protein) phosphatases II 41-259 1.7e-40 134.0 In-house 10-174 (176) alignment 
Range on Protein: 41-259
Range on HMM: 10-174/176.0
WPHEYIHANYVSTPtnpkRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDTmsfkekgqkvtvkfesskaikfrdnsaa
..  ||.||.. ..    |.|.||.||..|.|||. | .. .......|.. .|.|  ||. | | . . .                             
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

kvtktvltvegagcdklkvnHYHWIDWPDRGVPTAdN---AILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEyvmdqLLAGQIIEDTDKIIQKIREQR
                    .|....||| |||.  .    .||....|. ..||..||||||||||| .|..      ||  .   . .......||||
....................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqR

N-NSVQTDHQYLFVHQVMMNFFE
  ..|||..|| |...... ...
plgavqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 43-252 2.9e-40 133.1 In-house 5-155 (172) alignment 
Range on Protein: 43-252
Range on HMM: 5-155/172.0
HEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYkekgakkcheylptednkdtmsfkekgqkvtvkfesskaikfrdnsaakv
. ||.|.|....  |.|||.||.||  |.|||| |. .  . .|..|..                                                   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..................................................

tktvltVEGAGCDKLKVNHYHWIDWPDRGVPtADNAILELLEKARV-----SKGPIAVHCSAGIGRTGSVVMLEYVMdqllaG-QiieDTDKIIQKIREQ
      .  . . .  . .|... ||| |||   . .||.||  .      ..||..||||||.|||| .|.. ...           . ..... .||.
......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl...sleeavalvrek

RNNSVQTDHQYLFVHQ
|...||...|| |...
Rpgavqnpsqyrflyy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 17-257 5.9e-40 132.5 In-house 60-292 (319) alignment 
Range on Protein: 17-257
Range on HMM: 60-292/319.0
QEHGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCnykekgAKKCHEYLPTEDNKDTM
|.  |||. ..   |.|.|||    |    .|| | .|.   .....| .| ||. | |||| |  . .. || .|        .|| .| | . ..   
qnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

SFKEKGQKVTVKFEsskaikfrdnsaAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKA------RVSKGPIAVHCSAGIGRTGSV
 || | . |.   |              | .  |. .|   |. |.. .|.  ||| |||     .. |..|          . .| ||||||.||||  
rfkvkvdsveetae............yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvy

VMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN--F
..|. ..|..   . . |  .... .|.|||. ||   || |..  ...  .
ivldvlldrmkeekqv.dvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 17-258 1.1e-39 131.7 In-house 24-257 (284) alignment 
Range on Protein: 17-258
Range on HMM: 24-257/284.0
QEHGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCnykekgAKKCHEYLPTEDNKDTM
|.  |||. ..   |.|.|||    |    .|| | ...   .....| || ||. | |||| |  . .. || .|        .|| .| | . ..   
qnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikee

SFKEKGQKVTVKFEsskaikfrdnsaAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKA------RVSKGPIAVHCSAGIGRTGSV
 || | . |.   |              | .  |. .|   |. |.. .|.  ||| |||     .. |..|          . .| ||||||.||||  
rfkvkvdsveesee............yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

VMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN--FF
..|. ..|..   . . |  ......|.|||. ||   || |..  ...  .|
ivldvlldrmkeekqv.dvynfvrdlrqqrntlvqdlvqykfiysalleehlf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 11-258 1.8e-39 130.5 In-house 42-279 (315) alignment 
Range on Protein: 11-258
Range on HMM: 42-279/315.0
KAFKDAQEHGKNRYKDVGCLDNNRVKL--GGAWP-HEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTE
.  |. ... |||| ..   |. ||.|      |  .|. ||..   . ..|.|..|.|.  .  ||| .  .. . .| || |  |.  .|. .| | .
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

dnkdTMSFkekgQKVTVKFESSKAikfRDNsaaKVTKTVLTVEGAGCDklKVNHYHWIDWPDRGVPTADNAILELLEKARV----SKGPIAVHCSAGIGR
     . .     |.||   | .     ..      .|. .| |      .|  .|.  ||| |||    ....|  ....    | |.| ||||||.||
....kviy....Gkitvtrkseev...nte...ytvrtlsvvfgdnir..evvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGr

TGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
||. . |. |.||. | ..| |  ..|...|..| . ||. .|| |....... |
tGtfitldavldqaeaenai.dvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 20-266 1.8e-39 130.4 In-house 37-278 (285) alignment 
Range on Protein: 20-266
Range on HMM: 37-278/285.0
GKNRYKDVGCLDNNRVKLGgAWPHEYIHANYVSTPTNP-KRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPtEDNKDTMSFKEK
  ||| || |... || |     ..||||...  | .    .| || || .| .|||.|  |...  ..|||   | | .||  | | |   . . | . 
dlnryadvrcieetrvvlk.nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp.eklgevvkfgky

gqKVTVKFESSKAIKfrdnSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELL---EKARVSKGPIAVHCSAGIGRTGSVVMLEYVMD
  ..|.     .||      .   . ||.  | |  . | .|| .   |||.  |     ..||    .|    . ||.||||||.||| ..| ..|   
..eitlteckeeaia....gtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyati

QLLAGQIIEDTDkIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDE
...    ||  | |....|  | ..||.  |.||.. |.|..|   |... 
rimenpniemld.ivremramrfqavqshmqflflyvvlmeyfigegvver
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 18-255 3.1e-39 129.6 In-house 3-236 (237) alignment 
Range on Protein: 18-255
Range on HMM: 3-236/237.0
EHGKNRYKDVGCLDNNRVKLGGAWP-HEYIHANYVST-PTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDTMsf
.. |||| .. . | .|| | ||    .|| |.|.      ||..|..| ||| .| ||| |  |..   | ||    |.  .|||.| |  |.  .   
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay..

kekGQkVTVKFEssKAIKFRDNSaakVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILE----LLEKARV--SKGPIAVHCSAGIGRTGSVVM
   |. .|| .   |  .| | .   |   .|....   .   .  |..  |||||||    |.|     ......     ||  .|||||.|||| ...
...gv.ltvslk..kkeefsdyt...vrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

LEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM
.. .. |    ... |  . .. | |.|   .||  ||.|.||...
idamlrqakekkvv.diynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 16-255 3.6e-39 129.4 In-house 31-263 (283) alignment 
Range on Protein: 16-255
Range on HMM: 31-263/283.0
AQEHGKNRYKDVGCLDNNRVKLGGAwPHEYIHANYVS---TPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDT
 ... |||....   |..||.|    ...|| | ..       . |..| .|.||..|  ||| |  .... .| || . .|   .||  | | .  .| 
denkrknrnqeivpadqwrvelkse.srdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy

MSFKEKGQKVT-VKFESSKAIKFRDNsaakvtktvltveGAGCDKLKVNHYHWIDWPDRGVPTADNAI--LELL--EKARVSKGPIAVHCSAGIGRTGSV
  |    .| |  .  . | .  | |             ..  ..| . ||  ||| . |  .  |..  ....   . .  |||| ||||.|||||.  
Geftvtlrkettsnsfiikelllrvn.............ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

VMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM
. .   ....|.  .. |  .... .||||   |||  || .||....
iaasasvkdaltesvv.dvfavvkimreqrmmavqtldqyklvhelvl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 18-257 4.4e-39 129.4 In-house 51-283 (297) alignment 
Range on Protein: 18-257
Range on HMM: 51-283/297.0
EHGKNRYKDVGCLDNNRVKLGGAWPH---EYIHANYVstPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYkEKGAKKCHEYLPTEDNKDtms
.  |.|||..   | .||||     .   .|. | .|  ..| .|.|.|| | . | |||| | |...| || || .  ... |||  | . .  .    
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkgvtt...

FkekGqKVTVKFESSKAIKfrdnsaAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTAD--NAILELLEKAR-----VSKGPIAVHCSAGIGRTGSV
|   | .|.|. .| .  .        . ...   .|.   .  |. |....|||. |.  |  ...|.|..  |     ...||. |||.||.|||| .
f...G.dvsvvllsvsere......GfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvl

VMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNF
. .. |. .    . . |  ....|.|..| . |||. || ||.......
ltidsvvaeakrekev.difglvkklrqerpylvqtkeqykfvyvavlea
0036282 (Phosphotyrosine protein) phosphatases II 43-252 9.1e-39 128.3 In-house 2-164 (174) alignment 
Range on Protein: 43-252
Range on HMM: 2-164/174.0
HEYIHANYVSTPTNPKRFICTQAPLEktcadFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTednkdtmsfkekgqkvtvkfesskaikfrdnsaakv
. ||.|....    ..|.|..|.||.     || |. . ...|..||.. ||.|  ||. | |.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

tktvltveGAGCDKLKVNHYHWIDWPDRGVPTADNaILELLEKARVS-----KGPIAVHCSAGIGRTGSVVMLEYVMDQLLagQIIEDTDKIIQKIREQR
             .  . .|... |||.|||. .  .||... ..       .||..||||||.|||| .|.. ... .||  .  .|  ......| ||
........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqr

NNSVQTDHQYLFVHQ
 ..|||..|| |...
pgmvqtpsQyrflyy
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 16-258 5e-38 125.5 In-house 38-293 (301) alignment 
Range on Protein: 16-258
Range on HMM: 38-293/301.0
AQEHGKNRYKDVGCLDNNRVKLGGA-----WPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNK
 ...  ||.|..  .|.||. |          .||| |.|..  .. |.|| .|.|..|| .||| . .|... .| |..| ||.  .||..| |. ...
eenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseae

--DTMSFKEKGQK--VTVKFE-SSKAIKFRDNSAAKVTKTVLTVEGAGcDKLKVNHYHWIDWPDRGVPTADNAILELLEK-----ARVSKGPIAVHCSAG
  . . |. . ..  |   |   . ..| .| |  . ..  . |. .  .  .|  .. .|||. ||    . .|. ...      ....||. ||||..
seefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdt

IGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
..|.|  . ..  ..|  |  .. |  .... .| ..   |.|  || ....|.  ..
VsrsGvYcsvsiglEQckaegVV.dvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 17-256 5.1e-37 122.3 In-house 47-277 (439) alignment 
Range on Protein: 17-256
Range on HMM: 47-277/439.0
QEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAkkcheYLPTEDNkdtM
 .. |||||||| .|  || |    |     || |||.    ..| .| ||.| ..|. ||| . .. .. || ||.|  |        | |....   .
ydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdae...v

SFkekGqKVTVKFEssKAIKFRDNsAAKVTKtVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLE---KA--RVSKGPIAVHCSAGIGRTGSVV
 .   |  ..|. .  . |.. .  . .  | |.     .  .  | ..|.| |||. ||.    .|..|     |  .   ||. ||||||.||||...
cy...g.diavrvd..rnielpny.virgfk.vfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtii

MLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMN
 |.  ..|| . . . | . |.. .|.||.. ||.  ||.|... ...
aldialeqlklenkv.dikgivkvlrkqrkqmvqalcqyvfiynavle
0049772 (Phosphotyrosine protein) phosphatases II 17-260 2.4e-36 121.5 In-house 45-282 (314) alignment 
Range on Protein: 17-260
Range on HMM: 45-282/314.0
QEHGKNRYKDVGCLDnNRVKLgGA---WPHEYIHANYVSTPtnpKRFICTQAPLEKTCADF----------WFMCL--QDRVETIFM-------------
  . ||||.|. . | |||.| .      . ||.|.||...   ..||.||.||| |. ||          | | |  . .| .| |             
lnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------LCNYKEKGakkcheylptednkdtM----------SfkekgqkvtvkfesskaiK-------FrdnsaakvtktvltvegagcdKLKVNHYH
        |..  ..|                                              .       |                     .  . .|.
daAlgKtpllildgng................neptaadlellk..................eelydpelf.....................erlgikyl

WIDWPDRGVPtADNAILELLEKARV--SKGPIAVHCSAGIGRTGS-VVMLeYVMDQLlagQIieDTDKIIQKIREQRN-----NSVQTDHQYLFVHQVMM
.|..|| ..|  .. ..|.||  .    .||..|||.||.||||. ||.  |.| .|   ..  . ..... .|..|      .....  ||.|......
ripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaa.ylmkll...gv..sleealedvrlkRpinpnpgfieqleqyefileall

NFFEK
.....
eylkf
subfamily_egg_pd Subfamily egg 10-259 4.5e-36 119.1 In-house 33-271 (307) alignment 
Range on Protein: 10-259
Range on HMM: 33-271/307.0
MKAFKDaQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKgaKKCHEYLPT
 .|..|  .  | | | | | |  ||||    | .  ..||||.|.       ||..||||  |  ||| |  |..|. | ||   ||   ..|. | | 
ttaasd.nnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

EDNkDTMSFKEKGQKVTvkfeSSKAIKfRDNSAAKVTKtvLTVEGAGCDKLKVNHYHWiDWPDRGvptADNAILELLEKARVSKGPIAVHCSAGIGRTGS
 .. |.. .   . ...    . |  . . .   .|||  | . |.  ... ..|. . |.   .        |..| |.|    |. |..  |. ....
aes.dslvtvpGslrie....nlkvds.kadplfrvtk..lklvGgddeerflehwqg.dvnnss...dvysplrvlrklrnlskpvvvqdilGvskaat

VVMLEYVMDQLLAGQIIED-TDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
.| .|  . .|| | |      . .. .| .|. ||..  .||||..... || 
lvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
0049260 (Phosphotyrosine protein) phosphatases II 54-252 1.1e-35 117.9 In-house 5-144 (152) alignment 
Range on Protein: 54-252
Range on HMM: 5-144/152.0
PTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLptednkdtmsfkekgqkvtvkfesskaikfrdnsaakvtktvltvegag
  .|..||.||.|.. |.|||| |  .  . || ||..  |.|  ||..|                                                  
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................

cdklkvnHYHWIDWPDRGVPTADNAILELLEK----ARVSKGPIAVHCSAGIGRTGSVVMLEYVMdqllagqIIEDTDKIIQKIREQRNNSVQTDHQYLF
       .|... ||| |||. .  .|.||.     |. ..||..||||||.|||| .|.. ...          . ..... .||.|...|.. .|. |
.......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrf

VHQ
...
lye
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 12-257 6.3e-35 115.3 In-house 39-235 (392) alignment 
Range on Protein: 12-257
Range on HMM: 39-235/392.0
AFKDAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGakkcheylpted
. .   .  |||||..  .|..||||        ..|. | |. .  | | .|..|.|   .  ||| | .|..| || |. . ||              
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd............

nkdtmsfkekgqkvtvkfesskaikfrdnsaakvtktvltvegAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIA----VHCSAGIGRT
                                            | |.  |  .|. .|||..||   ...|..... ..  |  .    .|||||.|||
...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrt

GSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNF
| |. .. |. .    ... |  ... .||..|   |||. || |..  ... 
gvvisidsvvahakktrmv.dvfnfvtnirrkrpymvqtkeqyafiygavled
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 15-258 3.1e-34 113.6 In-house 45-288 (325) alignment 
Range on Protein: 15-258
Range on HMM: 45-288/325.0
DAQEHGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRvETIFMLCNYKEKGAKKCHEYLPTEDNKd
  ..  |||.|.|  ||..|| |   . .   .|| |.|. .  . . |. .|||| .|  |.| . |. |  .. .. |  ..| ..|  | | |  | 
kpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcavywpkemgk.

TMSFkekGqKVTVKFESSKAIkfRDNsaakVTKtVLTVEG-AGCDKLKVNHYHWIDWPDRGVPTADN---AILELLE----KARV---SKGPIAVHCSAG
.  |   |  . ||. . . |   |     | . || | .  . . . |. ...  |.| ||.       .||.|..    . .    . .|| ||||||
sktf...G.glevklrtieei..sdy....vhr.vldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

IGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
.||||  . |  ......    . |  . ..|.|..| . |.|  || .... .....
vGrtGvfislysalakvieesrv.difgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 11-260 9.3e-34 111.5 In-house 31-279 (287) alignment 
Range on Protein: 11-260
Range on HMM: 31-279/287.0
KAFKDAQEHGKNRYKDVGCLDNNRVKLG--GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEd
|| ..  .  |||| ||  .|..|| |   |    .|| ||||.. |. ..||..|.|.  |  ||| . |. |. .. ..    |.. .||..| |   
kaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.

nKDTMSFKekGQKVTVKfesSKAIKFRDnsaaKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTA----DNAILEL---LEKARVS--KGPIAVHCSA
 .  |     |  |..    .. ||  .      ....  ..  . .   |. .....|||.... .       .|.    .| || .   ||. ||...
.evPmrvG..Gysvvll...dydikePe....ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddv

GIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
||||.| .. .  ....|.    . |. ... ..||.|.  ||.  |. .. . .. ... 
GiGrsGillatlvlvsrledlGrv.dvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_PTPN9_pd Subfamily PTPN9 8-189 1.5e-33 111.1 In-house 32-205 (297) alignment 
Range on Protein: 8-189
Range on HMM: 32-205/297.0
SKMKAFKDAQEHGKNRYKDVGCLDNNRVKLG---GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYL
 ...|.|   .  ||||.|| |.|. ||.|    .    .||.||.|    ..| || || ||.||. ||| |  ...| .| |     |.|  || .| 
GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyW

PTEDNKdTMSFKEkgqkVTVKfesskAIKfrDNSAAKVTKTVLTVE-GAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVS
|.|... ...| .    ..|.      ..  ...  . ...||...     .. || |.  . ||| ||| . ...|..|||.|  
pleees.saefgd....lsvs.....nve..veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrek
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 14-254 2.5e-33 110.2 In-house 4-237 (239) alignment 
Range on Protein: 14-254
Range on HMM: 4-237/239.0
KDAQEHGKNRYKDVGCLDNNRVKLGG--AWPH-EYIHANYVST-PTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDN
|   .. |||| ..   | .|| |      || .|| |.|.     .|| .|.||  .| .. ||| |  |.|   | ||    |   ||||.| |   .
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts

KDTmsfkekGQKVTVKfessKAIKFRDnsaaKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV----SKGPIAVHCSAGIGRTG
|          .||..    |.  | |     . .|..  .    ..  | .||.  |||.|||    |.| |  |          |  .|||||.||||
kyc......nlrvtlr....ktevfad....yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtg

SVVMLEYVMDQLLAgQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVM
...... .. |    |   |  . .. |||.|   |||  ||.|.|  .
aflvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 16-255 2.9e-33 110.0 In-house 5-237 (239) alignment 
Range on Protein: 16-255
Range on HMM: 5-237/239.0
AQEHGKNRYKDVGCLDNNRVKLGG--AWPH-EYIHANYVST-PTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKD
  .. |||| ..   | .|| |      || .|| |.|.     .|| .|.||  .| .. ||| |  |.|   | ||    |   ||||.| |   .| 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

TmsfkekGQKVTVKfessKAIKFRDnsaaKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARV----SKGPIAVHCSAGIGRTGSV
         .||..    |.  | |     . .|..  .    ..  | .||.  |||.|||    |.| |  |          |  .|||||.||||..
c......nlrvtlr....ktevfad....yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

VMLEYVMDQLLAgQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM
.... .. |    |   |  . .. |||.|   |||  ||.|.|  ..
lvidamlrqakk.qktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 19-260 4.7e-32 106.3 In-house 19-262 (290) alignment 
Range on Protein: 19-260
Range on HMM: 19-262/290.0
HGKNRYKDVGCLDNNRVKL---GGAWPHEYIHANYVSTPTNpKRFICTQAPLEKT-------CADFWFMCLQDRVETIFMLCNYKEKGAK----KCHEYL
| ...  .|  . ..|| |   |     .|||||.|. | .  |.| ||.|.||.         .|| |  |..|. . |||. .|| |.     | .| 
hemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYv

PTEDNkDTMSFKekGqkVTVKFessKAIKFRDNsaakVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRT
|.. . . . ||  |  .|||    |   . |.    | .  |.|.  .  ...|.|.   .| .. |.     .|.|..| . || |. |||  || | 
pesvg.eelkfk..g..ltvkC...kskekedd....vetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrs

GSVVMLEYVMdQLLA-GQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM-NFFEK
  .  ..  . |..|  .    . ......|.||.. ....... ||  ...  ..| 
Aalaaiilgy.Qkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaiev
0044763 (Phosphotyrosine protein) phosphatases II 39-259 2e-31 104.4 In-house 14-172 (178) alignment 
Range on Protein: 39-259
Range on HMM: 14-172/178.0
GAWPHEYIHANYVStptnPKRFICTQAPlektcADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNkdtmsfkekgqkvtvkfesskaikfrdns
| .  .||.|...     |  ..... |     ||.. .  .  . .| .|.. .| |  ||..| |.| .                             
glersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.............................

aakvtktvltvegagcdklkvNHYHWIDWPDRGVPTA---DNAILELLEKAR-VSKGPIAVHCSAGIGRTGSVVMLEYVMDQllagQIieDTDKIIQKIR
                      .|..| .|| |||.      ...|..|.|.  ..||..||||||.||.|..|.. ... .    ..  . ...|. .|
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl..sleeaielvr

EQRNnSVQTDHQYLFVHQVMMNFFE
|.|.  |....|. ..... . ...
erRp.ivpnpgqlrqLyefelrllk
subfamily_PTPRN_pd Subfamily PTPRN 10-254 3.3e-31 103.1 In-house 48-288 (297) alignment 
Range on Protein: 10-254
Range on HMM: 48-288/297.0
MKAFKDAQEHGKNRYKDVGCLDNNRVKLGGAW---PHEYIHANYVST--PTNPkRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYL
 .. |. .   |||.|.|   |..||||        ..|| |  .    | .|  .| ||.|| .| |||| |  .. |  | .|.. .|.| |.|..| 
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap.ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckryw

PTEDNKDTMSFkEkgqkvtVKFEsSKAIKFRDNSAAK-VTKTVLTVegagcDKLKVNHYHWIDWPDRGVPTADNAILELLEKA----RVSKGPIAVHCSA
| | ..    . |      |..  |. |   |        | . |      .   |  .|.. ||..|||.. ...||.  |     |    || ||||.
pdeGsevyhiy.e......vhlv.sehiwcddylvrsfylknlqts.....etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsd

GIGRTGSVVMLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVM
| ||||  .... |...|| |    |    ....|.||.. |.| .|. |. ...
GaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
PTPc_DSPc_SM00012 158-255 3.5e-31 102.9 In-house 1-104 (105) alignment 
Range on Protein: 158-255
Range on HMM: 1-104/105.0
KVNHYHWIDWPDRGVPTADNAILELLEKARVSKG------PIAVHCSAGIGRTGSVVMLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVH
.|.|||. .||| |||.  ..|||||.. . .|       |. ||||||.|||| .|.|.....|| ...   |  .|....|.||...|||..||||..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

QVMM
....
rall
0051082 (Phosphotyrosine protein) phosphatases II 44-253 8.5e-31 102.0 In-house 4-148 (151) alignment 
Range on Protein: 44-253
Range on HMM: 4-148/151.0
EYIHANYVSTPtnpkrFICTQAPLEktcaDFWFMCLQDRVETIFMLCNYKEKGakKCHEYLPTEDnkdtmsfkekgqkvtvkfesskaikfrdnsaakvt
 ||...||        ......||.    ||. .  .  . ||..|.. .| |  .|.|||| ..                                   
dyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................

ktvltvegagcdkLKVNHYHWIDWPDRGVPTADNAILELLEKARVS-KGPIAVHCSAGIGRTGSVVMLEYVMDQllagqiiEDTDKIIQKIREQRNNSVQ
             ..| |....|||| |.|.  .|.||.||...   .||..||||||.|||| .|.|  .. .        . ..... .|..| ..||
.............ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq

TDHQYLFVHQV
.  |.||....
pnqqflfqlfa
subfamily_CG7180_pd Subfamily CG7180 16-257 1.4e-30 101.0 In-house 40-289 (296) alignment 
Range on Protein: 16-257
Range on HMM: 40-289/296.0
AQEHGKNRYKDVGCLDNNRV---KLGGAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAkKCHEYLPTEDnkdt
..  .|||. .|   |.|||   ||.|    .|| | || . . .| .| |.|| ..|  .|| .  .. .... .|..  .    ....|.| .     
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks....

msfKEKGQKVTVKFESSKAIKFRDNSAAKVTKTVLT----VEGAGCDKLKVNHYHWIDWPD-RGVPTADNAILELLEKARV---------SKGPIAVHCS
   ||. ... |.  ..|          |.||....     ..   ..  | ....  |.    ||   ||..||....|.          .||. |..|
...keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss

AGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNF
 | .|.|  . ..  ....   . . |  . ....|..|.. |.. ..| .. .|. ..
dGasRsGvylaidanlelvekeeev.dvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 17-259 3.3e-30 100.0 In-house 46-345 (350) alignment 
Range on Protein: 17-259
Range on HMM: 46-345/350.0
QEHGKNRYKDVGCLDNNRVKLG-----------GAWPHEYIHANYVSTP-----TNPK-RFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKK
.   |||||..   . .||||               . .|| |||.. .      ||. ..| ||||| .|  ||. ..|.. |. | .| .  | . .|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CHEYLPTEDNKD-----------TMSFKEKGQK-VTVKFESSKAIKFRDNSAAKVTKTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTADNAILELLE---
|..| .  . .|           .|. ..  .  . || |.|.     |.   |  ...  .. | .| . | . ..  |.| ..    . ||. ||   
cyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkn

------KA-----RVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQ--------------IIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
       |          || ||||||.|||| .| |.... ...  .              . .    |....|.|| . ||. .|..|... ....|.
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyfa
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 17-174 3.1e-28 93.5 In-house 29-181 (297) alignment 
Range on Protein: 17-174
Range on HMM: 29-181/297.0
Q---EHGKNRYKDVGCLDNNRVKLGGAWP-HEYIHANYVSTPTNPK--RFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNK
.      ||||.|.   |..|||| .. . ..|| |.||  | ...  ..|..| ||..|  ||| .  .. | .| |... .| | .||  | |  ...
krnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqe

dtmsfKEKGQKVTVKFESSKAIKFrdnsaAKVTKTVLTVEGAgCDKLKVNHYHWIDWPDRGVPT
     . |  .| |.| || . .|      .|  | |..     .. .|.|  .. ||| |||.
.....rlkagdvvveflsstsdef.....drviltelqliyr.sesrvvrhvqflswpdhGvps
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 69-275 2.3e-26 87.4 In-house 39-238 (255) alignment 
Range on Protein: 69-275
Range on HMM: 39-238/255.0
KTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKdtmsfKEKGQKVTVKFESskaikfrdNSAAKVTKTVLTVEGAG--CDKLKVNHYHWID
 | . |. .  | . |.. |||...|.| .||..|.|.| ..     | | ..|.|            .||  | .|.  .   |      .|.||..  
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekde.....klkladvnvtttk........ssadvvlrtleitstlgekkkthtvkhysykG

WPDRGVPTADNAILELLEKARVSKgPIAVHCSAGIGRTGSVVMLEYVMDQLLAG----QIIE-DTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKR
|...  |   . ||..|  .| || .. ||||.||||. . |. |.|  ...      . .| |  ......|..|. ...|  |  |   ......  .
WieknaPelareilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpk

GLLDEATSAIHKDF
| |... . |.| .
geleakyqeirksy
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 8-261 2.4e-26 86.9 In-house 43-288 (302) alignment 
Range on Protein: 8-261
Range on HMM: 43-288/302.0
SKMKAFKDaqEHGKNRYKDVGCLDNNRVKLGGAwPHEYIHANYVSTPTNPKRFICTQAPLEKTC---ADFWFMCLQDRVETIFMLCNYKEKGAkKCHEYL
 | ||||.  .  ||. .|| .||.|.|||... | .|..|  |. |   .  | .| |  ..    ..|| |  |... ....|   .|      .|..
ekCkafkk..nlkknqsedvpildsnlvkleae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlself

PTEdnkdTMSFKEKGQkVTVkfESSKaIKFRDNSAakvTKTVLTVEGAGCD-KLKVNHYHWIDWPDRGVPTADNAILELLEKA----RVSKGPIAVHCSA
|..    . ..|| |. . |     | ..  ....   |. |. |   ||   . .| |.   |..  ||.  ... .  .|       .. ....    
pkk....sgdykeygk.mfv..Nnrk.Vekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSkn

GIGRTGSVVMLEYVMDQLLAGQIIEdTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKR
|.|| |... |  ....| .|.  .    |...||.|| ..|.. .|| ... ... .. |.
GaGRagafltlavaveklqkgkepn.ikeivksiRsqRpravdslkQyvslyialllyikkk
subfamily_ptpA1_pd Subfamily ptpA1 18-215 2.4e-26 87.4 In-house 47-254 (418) alignment 
Range on Protein: 18-215
Range on HMM: 47-254/418.0
EHGKNRYKDVGCLDNNRVKLGGAW---PHEYIHANYVSTpTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDTMS
.  |||| ..  ..  ||.|         .|| |||.   . ||.||||| || .| |||| |  ..|.  | ||    |.   ||  | | .   . .|
ntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

FKEKGQKVTVKFESSKAIKFRDNSAAKVTKTV-LTVEGAGCDklkVNHYHWIDWPDRGVPTADNAILELLEKAR----------VSKGPIAVHCSAGIGR
   .|..|   .        .|     .|. . ||.||   |   . .|..  |||. .|   . . .||                . || ||||||.||
iygngnevfgtysvelveviqdpereiitrnirltfegetrd...itqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGSVVMLEYVMD
||...    .| 
tgtfctavimmk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 64-253 4.2e-26 86.1 In-house 97-284 (302) alignment 
Range on Protein: 64-253
Range on HMM: 97-284/302.0
QAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTeDNKDTMSFKEKGQKvTVKFESsKAIKFRDNSAAKVTKTVLTVEGAG-CDKLKVNHY
  |  .|.  .| .  | .|  .  ||...|.. ||| ||  . . .... |..   | ||. .  .  .| |  ..|. .  .. |      |  |.  
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd.kvggelkfgrytvk.tvsvkt.dleeftdkksfklytveiknekkkkkvkktvdil

HWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMdQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQ-V
..  ||| | |   .. |..|      |  . ||||||.||||..| . | . || . . . |  .|.. .|. |  .||...| ...   |
afsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGi.qlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 18-272 4.8e-25 82.8 In-house 47-293 (303) alignment 
Range on Protein: 18-272
Range on HMM: 47-293/303.0
EHGKNRYKDVGCLDNNRVKLGGAwphEYIHANYVSTPTNpKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPteDNKDTMSFKE
.  |||. || |||  .|||  .    ||||.|.   .. |. | || || .|.|||| | ....|  ...|    |      .  .|   |.| . |.|
nmdknrfvdvicldhskvklsds...syihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfp..rnqdflkfee

KGQKVTvkfeSSKAIKFRDNSAAKVtktVLTVEGAGCDKLKVNHYHwiDWPDRGVPTA-----DNAILEL---LEKARVSKGPIAVhCSAGIGRTGSVVM
.  .|       | ... |  . ||   .   .|     |.| ||.  .||   .|.       . | .|   | |   |. .. .   .| ||.|.  .
rsirvg....efkrvelgdgwvlkv...lsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvym.slsgcgragtfal

LEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEKRGLLDEATSAIH
.|     | . |   |  | ....|. |  .||   |. .|. .. .   . |.   | .   
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngicklaipkkp
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 16-260 2.8e-24 80.5 In-house 31-261 (267) alignment 
Range on Protein: 16-260
Range on HMM: 31-261/267.0
AQEHGKNRYKDVGCLDNNRVKLGGAwPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHeylPTEdnkdtMSF
 . . .||. |.   |..|| |     .||| | || .    . || || ||..| .||. .  . .| .| .| .  .   .. .   | .     |  
eknqernrlddnlpyddtrvilrtk.eeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfw...PPk.....mgq

KEKGQKVTVKFESSKaikfRDNSAAKVTkTVLTVEGAGCDKLKVNHYHWIDWPDRGVPTAdNAILELLEKARVSKG--PIAVHCSAGIGRTGSVVMLEYV
 .| | .||..   |     .|    .|   | ..   . .. . .|.  .      |   . .. .| | .. .|  |. |.||.|.||.|. ....  
akkyqdltvehslek....eendyqiit.lelkfknesahnvtlyyykkwnintnnkpyl.kplfgilaknqlengnrPlvvacsdGvGrsGtflvidsq

MDQLLAGQiIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
....   . . |  . ..|||.||   |.|  .|...|... .. | 
lerakteg.vsdifdflrkirsqriglvdtkeryiyihellaeyaeg
0048076 (Phosphotyrosine protein) phosphatases II 156-255 4.6e-23 76.9 In-house 44-140 (145) alignment 
Range on Protein: 156-255
Range on HMM: 44-140/145.0
KLKVNHYHWIDWPDRGVPTADNA---ILELLEKARVSKGPIAVHCSAGIGRTGSVVMLeYVMDQllaGQiiEDTDKIIQKIREQRNNSVQTDHQYLFVHQ
. .. .|....|||.|||.  .    .||..|.|. ..||..||||||.||||..|.. |.| .    .   . .......|.|| ..|....|. |...
erlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll...lg..vsleealelvrsqrpgavpnpgqlrflye

VMM
. .
fel
subfamily_CG42327_pd Subfamily CG42327 42-189 1.1e-22 75.1 In-house 55-193 (319) alignment 
Range on Protein: 42-189
Range on HMM: 55-193/319.0
PHEYIHANYVSTPTN-PKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKDTMSFKEKgQKVTVKFESSKaikfrdNSAA
  ||..|.||  . . |  .|..|..||.. .||| .  . .  .|  |..  |.| |.| |||||..  |  |   .  .||.|   .|      .  |
kdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGd.ilvtlkgrevk......drya

KVTKTVLTVEGAGCDKlkVNHYHWiDWPDRGVPTADNAILELLEKARVS
  |  .  |..  . .  . || . .|.. .||. ..|.. .| ..| |
istlllkrvdkeesre..lthywy.kwleaevPaeeaaliamllevrss
subfamily_hpo-7_pd Subfamily hpo-7 66-267 4e-22 73.4 In-house 42-236 (263) alignment 
Range on Protein: 66-267
Range on HMM: 42-236/263.0
PLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTEDNKdtmsfKEKGQKVTVKFESSKAikfrdnSAAKVTKTVLTVEGAGCDKLKVNHYHWI
 | .| . |. .  | . |.. |||...|.| .|| .|.|.| ..     | | ..|.|    ..          . |. .| . |      .|.|| . 
llvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekde.....kqklanvnvcttkvqs......dvllktlellstlgeKkkthtvkhysyk

DWPDRGVPTADNAILELLEKARVSKgPIAVHCSAGIGRTGSVVMLEYVMDQLLAG----QIIE-DTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFEK
 |...  |.  . ||..|. || || .. ||||.||||. . .. | |  ...      . .| |  ......|..|. ...|  |  |   ....|. .
gWiekndpelareilnilkvarnsk.slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln

RGLLDEA
    .|.
nfakgel
0048179 (Phosphotyrosine protein) phosphatases II 157-252 4.4e-22 73.8 In-house 47-139 (144) alignment 
Range on Protein: 157-252
Range on HMM: 47-139/144.0
LKVNHYHWIDWPDRGVPTADNAILELLEKARVS---KGPIAVHCSAGIGRTGSVVMLEYVMdqllAGQiiEDTDKIIQKIREQRNNSVQTDHQYLFVHQ
  . .|....|||.|||.  . .||.||  .     .||..||||||.||||..|..  ..      .   . ..... .|..| ..|....|. |...
regiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPN9_pd Subfamily PTPN9 189-258 5.7e-18 60.0 In-house 222-290 (297) alignment 
Range on Protein: 189-258
Range on HMM: 222-290/297.0
SKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
|. || |||||||||||  . |.. ...|   . . |  . ....|.||  |.||..|| | .. .... 
sgPPivvhcsaGiGrtGtfitldiclsrleevgtv.dvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 155-276 2.7e-16 53.9 In-house 87-207 (440) alignment 
Range on Protein: 155-276
Range on HMM: 87-207/440.0
DKLKVNHYHWIDWPDRGVPTADNAILELLEKA-----RVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLF
.   ...||.  |||.|||     .|....       ....||. |||||| |||| .. .. .. .    . | |   .|. .|..| . ||| .|| |
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqi.difsfinsmrnnrpqmvqtpeqyaf

VHQVMMNffekrGLLDEATSAIHKDFT
||.....     |||   |  .. | |
vheavle.....gllcgdtlileddit
subfamily_CG42327_pd Subfamily CG42327 187-258 1.4e-14 48.5 In-house 244-315 (319) alignment 
Range on Protein: 187-258
Range on HMM: 244-315/319.0
RVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFF
| |.||..|||| |.|||| |.  .  . .|   .   |  .... .|..| ..|.| .|| |...|. .. 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 181-255 2.9e-14 47.6 In-house 219-292 (297) alignment 
Range on Protein: 181-255
Range on HMM: 219-292/297.0
ELLEKARVSKGPIAVHCSAGIGRTGSVVMlEYVMDQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM
| |. .   . .. ||||||.||.| ||.   |. . |  . | |.  |....||||   ||| .|. .......
eslraemprnayllvhcsaGvGrsGvvvl.sdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_PTPDC1_pd Subfamily PTPDC1 162-261 1.3e-13 45.8 In-house 85-179 (182) alignment 
Range on Protein: 162-261
Range on HMM: 85-179/182.0
YHWIDWPDRGVPTADNaILELLE--KARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLagqiieDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
.. . |.| ||.. .. ||..    .  ...| .|||| || |||| ..    |  . |      ...| |...|..| .|.|| .|  .|.. ..   .
vynfgwkDygvasler.iLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrl......taekaiklvrskrpksiqtreqvelvkefalflip

KR
.|
lr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 38-105 4e-13 43.4 In-house 85-154 (349) alignment 
Range on Protein: 38-105
Range on HMM: 85-154/349.0
GGAWPHEYIHANYVSTPT--NPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLP
 .. ...|| |||.. .     |..|.|||||  |  ||. . | ..|. .. | . ||.. .||. |  
dsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 58-253 4.2e-11 37.4 In-house 4-198 (198) alignment 
Range on Protein: 58-253
Range on HMM: 4-198/198.0
KRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNY-KEKGAkKCHEYLPTEDNKdTmsFKEKGQKVTVKFESSKAikfrdNsaAKVTKTVLTVE-GAGCD
.|.|.|| || .| |||| |  .     | |. .  |.| |     | || ..  |   |     ||.|  ..|.     .    .|  .|| .  |   
rryiatqhplretladfwqmvwetgsghivmvnddqknkea.dypfywpttesg.t..gkygslsvttktittkp.....d..ytitaliltnnttapps

KLKVNHYHWIDWPDRGVPTADNAILELLEKARVSK-------GPIAVHCSAGIGRTGSVVMLEYVM-DQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQY
  .. || .  | ..  |     .  ..    |||        |. |||| | | ||  | |.  .  .  .   . |  .. ...|. |   . . ..|
treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

LFVHQV
 |..||
nfiyqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 58-253 4.3e-11 37.3 In-house 5-199 (199) alignment 
Range on Protein: 58-253
Range on HMM: 5-199/199.0
KRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNY-KEKGAkKCHEYLPTEDNKdTmsFKEKGQKVTVKFESSKAikfrdNsaAKVTKTVLTVE-GAGCD
.|.|.|| || .| |||| |  .     | |. .  |.| |     | || ..  |   |     ||.|  ..|.     .    .|  .|| .  |   
rryiatqhplretmadfwqmvwetgsghivmvnddqknkea.dypfywpttesg.t..gkygslsvttktittkp.....d..ytitaliltnnttapps

KLKVNHYHWIDWPDRGVPTADNAILELLEKARVSK-------GPIAVHCSAGIGRTGSVVMLEYVM-DQLLAGQIIEDTDKIIQKIREQRNNSVQTDHQY
  .. || .  | ..  |     .  ..    |||        |. |||| | | ||  | |.  .  .  .   . |  .. ...|. |   . . ..|
treishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

LFVHQV
 |..||
nfiyqv
0038934 (Phosphotyrosine protein) phosphatases II 161-253 9.8e-11 37.1 In-house 81-172 (194) alignment 
Range on Protein: 161-253
Range on HMM: 81-172/194.0
HYHWIDWPDRGVPTADNAILELLEKAR-----VSKGPIAVHCSAGIGRTGSVVMLeYVMDQLLAgqiieDTDKIIQKIREQRNNSVQTDHQYLFVHQV
.|. . .||.|..  .. .|. |. .       ..| .|||| ||.|||| .|   | .  |       . .. |. .|| |...... ...  ... 
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrlgm.....saeeAialfrekRpgaipnqdyleallkr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 6-95 1.7e-09 31.6 In-house 84-174 (244) alignment 
Range on Protein: 6-95
Range on HMM: 84-174/244.0
DFSKMKAFKDAQEHGKNRYKDVGCLDNNRVKLG-GAWPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEK
| | ||   . ..  |||      .| ||| |  |.    || | .|        .| || ||  |  ||| | |.  |. . .|   .|.
dpsvmkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_eak_pd Subfamily eak 30-176 6.5e-09 29.6 In-house 63-198 (332) alignment 
Range on Protein: 30-176
Range on HMM: 63-198/332.0
LDNNRVKLGGA--WPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKGAKKCHEYLPTeDNKDTMSFKEkgQKVTVKfe
 | . |.|  .   .  || |  .  .   ...| | .. |.    || | |. .  .| .| .  |.. .|   |.|  . .. ..|     .|. |  
ydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd.ktreelkfGi..ldverk..

ssKAIKfRDNsaakVTKTVLTVEgAGCDKLKVNHYHWIDWPDRGVPTAD
  . .| |..    .    | ..  | .  .| ||.   | .  .|  .
..efvk.rni....letrllels.kGnethrvlhykvfGwtettlpkye
subfamily_DSP19_pd Subfamily DSP19 156-238 6.6e-09 30.3 In-house 55-131 (152) alignment 
Range on Protein: 156-238
Range on HMM: 55-131/152.0
KLKVNHYHWIDWPDRGVPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMlEYVMDQLLAgqiieDTDKIIQKIREQRN
.... . . .| |.  . .  ...|. .|.|| ..| . |||.||. |. |||.  |.| .  .     .. . ....||.| 
dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvvi.aylmkkeel.....sleealelvrearp
PTEN_1 162-246 1e-08 30.2 In-house 97-181 (196) alignment 
Range on Protein: 162-246
Range on HMM: 97-181/196.0
YHWIDWPDRGVPTADNAI--LELLEKARVS---KGPIAVHCSAGIGRTGSVVMLeYVMDQLLagqiiEDTDKIIQKIREQR-NNSVQTDHQ
|. ....| |.|. .  .  .. .. .. |   .. ..||| ||.||.| ||.  | |          . |. .. .||.| ...... .|
ylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa.yLmykgk.....ltadeAlelvrekRppgapnspsq
subfamily_DSP23_pd Subfamily DSP23 162-253 2.3e-08 28.8 In-house 54-141 (148) alignment 
Range on Protein: 162-253
Range on HMM: 54-141/148.0
YHWIDWPDRGVPTADN--AILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGqiiedtDKIIQKIREQRNNSVQTDHQYLFVHQV
.. .  .|   |. ..   .....|.|   .  ..|||  | ||||...   .|  . ||        . | ..|..|  ||.|  |   |.. 
lvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaa......aeaiaevrrlrpgsvetveqeklvrdy
subfamily_CDC14_pd Subfamily CDC14 171-254 3.5e-08 27.6 In-house 245-322 (328) alignment 
Range on Protein: 171-254
Range on HMM: 245-322/328.0
GVPTaDNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMlEYVMDQLLAgqiieDTDKIIQKIREQRNNSVQT-DHQYLFVHQVM
..|. |. . ..|| |  ..| ||||| ||.||||...   |.| .         .  .|  .|  |  || .  ...|  .| .
stPs.daivkkfleiaekaeGaiavhCkaGLGrtGtLia.cylmkhyrf.....taaeaiawlricrPGsvigpqqkfleekqaa
DSPc Dual specificity phosphatase, catalytic domain 177-217 4.3e-08 28.1 Pfam-A 60-99 (133) alignment 
Range on Protein: 177-217
Range on HMM: 60-99/133.0
NAILELLEKARVSKGPIAVHCSAGIGRTGSVVMlEYVMDQL
... | .|||. ... ..||| ||| |......  | |.. 
eeavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmktk
DSPc Dual specificity phosphatase, catalytic domain 177-217 4.3e-08 28.1 In-house 60-99 (133) alignment 
Range on Protein: 177-217
Range on HMM: 60-99/133.0
NAILELLEKARVSKGPIAVHCSAGIGRTGSVVMlEYVMDQL
... | .|||. ... ..||| ||| |......  | |.. 
eeavefiekaeqkgkkvlVHCqaGisRSatlii.aYlmktk
PTPc_motif_SM00404 177-217 8.2e-08 27.2 In-house 67-106 (140) alignment 
Range on Protein: 177-217
Range on HMM: 67-106/140.0
NAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLeYVMDQL
...|. .|.|. ..| . ||| ||. |......  |.|.. 
dkvldfienaekkggkvlVHCqaGvSRSatliia.Ylmryr
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 189-242 1.3e-07 25.5 In-house 270-322 (347) alignment 
Range on Protein: 189-242
Range on HMM: 270-322/347.0
SKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGQIiEDTDKIIQKIREQRNNSVQ
 . |. | |  |. |. .||.   ...|.|.|.   | |....|.|.||     
klapvvvmcdlgldrsatvvltsiiieqvldgkt.pdcddlfkkmrdqragvft
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 33-96 2e-07 25.3 In-house 8-66 (130) alignment 
Range on Protein: 33-96
Range on HMM: 8-66/130.0
NRVKlggawPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEKG
.|..      ..||.|..|    . . .. ||.|| .|. ||| | |.  |. . .|   .|. 
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 194-255 4.2e-07 24.3 In-house 2-62 (69) alignment 
Range on Protein: 194-255
Range on HMM: 2-62/69.0
AVHCSAGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM
 ||||.| ||||. . .   | .. . ... |    .| .|  |   |  . .|.|.|  ..
vvhcssgtgrtgtfiaimvemarikseklv.difnnvqymrkcrpmmvmneieyifihdalv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 190-259 4.4e-07 23.5 In-house 265-345 (349) alignment 
Range on Protein: 190-259
Range on HMM: 265-345/349.0
KGPIAVHCSAGIGRTGSVVMLEYVMDQL----------LAGQIIEDT-DKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE
  .. |||||| |||| .| |..... |             .. .|    |. ..| || . ||   |. .... ....| 
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 68-262 5.4e-07 22.5 In-house 128-314 (346) alignment 
Range on Protein: 68-262
Range on HMM: 128-314/346.0
EKTCADFWFMCLQDRVETIFMLCNyKEKgAKKCHEYLPTEDNKdtmSFKEKGQkVTVKfeSSKAikfrDNSAA--KVTKTVLTvEGaGCDKLKVNHYHWI
|    |||.|  |.... ....    .|  |.    |  ..|     ..  |. . ..    .|    | |    . |  ||  ||   | . .. .|  
esfvedfwymiyqeqihlvylmvp.ddk.lkntttslfndeng...gyqytgk.mfin..nrra....dvsgdpkeytievlp.eg.nsdsvicqvhhha

DWPDRGVPTADN----AILELLEKARVSKGPIAVHCSAGIGRTGSVVMLEYVMDQLLAGqIIEDTDKIIQKIREQRNNSVQTDHQYLFVHQVMMNFFE-K
 |     |         | ..| . .| .  . |    | ||. | .   | ..||  | |  .  .|...|..||  .|..  ||  .. .....   |
pwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnng.iepniceimknikqqrpggvesfaqyasiyaivfdyiark

RG
||
rg
subfamily_DSP8_pd Subfamily DSP8 179-252 6.3e-07 23.1 In-house 82-146 (159) alignment 
Range on Protein: 179-252
Range on HMM: 82-146/159.0
ILELLEKARVSKGPIAVHCSAGIGRTGSVVmLEYVMDQLLAGqiiedTDKIIQKIREQRnNSVqtDHQYLFVHQ
 .| ..||. ..| . ||. ||| |  .|. . |.| .|  .      |.  . ..|.| ...  . .. |. |
svefidkaksengrvlvhvlaGisrsatva.iayimktlems.....ldeayrfvkekr.pti..spnlnflgq
subfamily_DSP1_pd Subfamily DSP1 172-217 7.4e-07 23.4 In-house 77-121 (163) alignment 
Range on Protein: 172-217
Range on HMM: 77-121/163.0
VPTADNAILELLEKARVSKGPIAVHCSAGIGRTGSVVMLeYVMDQL
. .  . ..| ..... ..| . .|| ||| |  ..... |.| . 
islvfeeviefidevkkknGkvlihCqaGisRsstlcla.ylmktk
subfamily_PTEN_pd Subfamily PTEN 193-251 8.8e-07 24.1 In-house 117-173 (184) alignment 
Range on Protein: 193-251
Range on HMM: 117-173/184.0
IAVHCSAGIGRTGSVVmLEYVMDQLLAgQIIEDTDKIIQKIREQRNNSVQTDHQYLFVH
..||| || |||| ..   |.. .||  .  |.. .. ...| . ...|.   |  .|.
vvvHCkaGkGRtGvli.vayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_Cele-PTP-2_pd Subfamily Cele-PTP-2 29-113 8.9e-07 20.8 In-house 56-139 (327) alignment 
Range on Protein: 29-113
Range on HMM: 56-139/327.0
CLDNNRVKLGGawPHEYIHANYVSTptNPKRFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEK---GAKKCHEYLPTEDNKDTM
  || ||  |     |..  .||    .   .|  ||| .|.    | . |.|..  .  ||  ..       ||. |.||| ..   
irdnrrvlcgs..deeffpgqyvrm..egaeyiivqaptkksskliwrvilkdhirilvclchdeqmsgsddgkcytyfpteleqkme
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 195-255 1e-06 23.0 In-house 2-61 (69) alignment 
Range on Protein: 195-255
Range on HMM: 2-61/69.0
VHCSAGIGRTGSVVMLEYVMDQLLAGQIIeDTDKIIQKIREQRNNSVQTDHQYLFVHQVMM
||||.| ||||. . .   | .. . ... |    .| .|  |   |  . .|.|.|. ..
vhcssGtGrtGtfiaimvemarikseklv.difnnvqymrkcrpmmvmneneymfihdalv
subfamily_DSP10_pd Subfamily DSP10 177-232 3e-06 21.2 In-house 79-131 (159) alignment 
Range on Protein: 177-232
Range on HMM: 79-131/159.0
NAILELLEKARVSKGPIAVHCSAGIGRTGSVVmLEYVMDQLlaGQIIEDTDKIIQK
.. || .|.|| .   . ||| ||| |  .|| . |.| .|  .. ..|  | ...
eealefieearkkgsrvLvhCqaGisrsatvv.iaYlmkhl..nlslndaykfvke
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 59-112 3.3e-06 20.7 In-house 237-287 (440) alignment 
Range on Protein: 59-112
Range on HMM: 237-287/440.0
RFICTQAPLEKTCADFWFMCLQDRVETIFMLCNYKEkgaKKCHEYLPTEDNKDT
 ||.|| ||. |  ||| .  . |. || || . ..   | |  | | .    |
afiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvt
subfamily_CDKN3_pd Subfamily CDKN3 163-253 3.9e-06 20.6 In-house 103-191 (202) alignment 
Range on Protein: 163-253
Range on HMM: 103-191/202.0
HWIDWPDRGVPTADNAiLELLEKARV---SKGPIAVHCSAGIGRTGSVVMLEYvmdqLLAGQIIEdTDKIIQKIREQRN-NSVQTDHQYLFVHQV
|    .| .||   .  |..||. |.   .     |||  |.||.  |.        |.  . ||  .. |.|.|. .  ...|| .|| .... 
hhypiadglvpdiasc.lkileelrinlkayrktlvhcygglgrsslviacll....lylddtie.pkdaidklrdlkgsraiqtvkqynylsef
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 18-89 5.2e-06 20.2 In-house 37-116 (347) alignment 
Range on Protein: 18-89
Range on HMM: 37-116/347.0
EHGKNRYKDVGCLDNNRVKLGG-------A-WPHEYIHANYVSTPTNPKRFICTQAPLEKTCADFWFMCLQDRVETIFML
.  ||| |||   |. || |         |  .. || | ..      | .| || || .|  ||| |    .|  .  .
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_PRL_pd Subfamily PRL 180-248 8.2e-06 20.0 In-house 78-140 (151) alignment 
Range on Protein: 180-248
Range on HMM: 78-140/151.0
LELLEKA--RVSKGPIAVHCSAGIGRTGSVVMLEYVMDqllaGQIIEDtdkIIQKIREQRNNSVQTdHQYL
||||...  . .|  .|||| ||.||.  .| |  . .    |   ||    .. |||.|.... . .|  
lellkekfkeepkstvavhcvaGlGraPvlvalaliea....Gmkyed...avefirekrrgains.kqlk