Gene K09F6.3 in Caenorhabditis elegans

Synonym: CELE_K09F6.3, K09F6.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily hpo-7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP120_AA protein Get Run
CeleP120_AA_916-1253 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_hpo-7_pd Subfamily hpo-7 913-1288 3.3e-149 490.0 In-house 2-263 (263) alignment
Range on Protein: 913-1288
Range on HMM: 2-263/263.0
LLNdfmkeegDKGATNNGKLPlkamyqfcksilrianlapnnaivesekyseqdrysdvlcgmdnRILIDEDVCrrcyfkdqyinanylelpngnrmilt
|||       ||||...||||                                            |||||||||                          
lln.......dkgalkfgklP............................................rilidedvc..........................

qapmsrTEHFKPEKDKKRKNLYSLsdeeeeisyLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpsaDVVL
      ||||||||||||||||||         ||||.||||||||||.||||.||||||||||||||||||||||.|||..|||||||.||.   ||.|
......tehfkPekdkkrknlysl.........lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvll

RTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSKSLVVHCSNGIGRSAAfvswelcyhfvpvnfeicdFSVAEFVYQKMIRSLDT
.||...|.||||||||||||||||||||||.|||.||||||..|||||||||||||.|||||||                   |||||.|||||||||||
ktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarnskslvvhcstGiGrsaa...................fsvaElvyqkmirsldt

TSTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNFPKGEMEAKYQEIRKSYLHARQMMHKDLEFDGS
||||.||.||||.|||.||.|||||||||||||.||||||.|||.|||.|||||||||||||||||||||||||||
tstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeirksylharqmmhkdlefdgs

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 923-1289 9.6e-144 472.0 In-house 2-255 (255) alignment
Range on Protein: 923-1289
Range on HMM: 2-255/255.0
DKGATNNGKLPlkamyqfcksilrianlapnnaivesekyseqdrysdvlcgmdnRILIDEDVCrrcyfkdqyinanylelpngnrmiltqapmsrTEHF
||||....|||                                            |||||||||                                |||.
dkGalkfkklP............................................rilidedvc................................tehv

KPEKDKKRKNLYSLsdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNvqhPSADVVLRTLVITSYLG
||||||||||||||            ||||||||||||.||||.|||||.||||||||||||||||.|.|...|||.||.   .|||||||||.|||.||
kPekdkkrknlysl............tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlg

EKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSKSLVVHCSNGIGRSAAFVswelcyhfvpvnfeicdfsVAEFVYQKMIRSLDTTSTVNLDFLS
||||||||||||||||||||||||.||||||..|.|.|||.|||||.|||||||||                   .||.||||||||||||.||.||.||
ekkkthtvkhysykGWieknaPelareilnilkvvrdsksvvvhCstGiGrsaafv...................laelvyqkmirsldttetveldyls

LLTELRHSRPRAIHTPMQLAFSIMMVLDFVmnnFPKGEMEAKYQEIRKSYLHARQMMHKDLEFDGSD
||.|||..|.||||||.||||||.||||.|   |||||.||||||||||||||||||||||||||||
lleelrskrkraihtPlqlafsilmvldlv...fpkgeleakyqeirksylharqmmhkdlefdgsd

DSPc_SM00195 945-1252 3.6e-63 208.7 In-house 7-262 (263) alignment
Range on Protein: 945-1252
Range on HMM: 7-262/263.0
LRIANLAPNNAIVESEKYS--EQDRYSDVLCGMDNRILIDEDVCRrcyFKDQYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeee
 .. . .... . |.|| .  ...||...|. ...|. .... ..    ...||||||.... . ...|.||.|.                         
ekleestspketteaekkknksknRyknilpydhtrVklkkeekk...egsdYINAnyikgankkkkyIatQgPl.........................

eisylVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGekKKTHTVKHYSYKGWIEK
      .||..|.............||....|.| |||..|.| |..||..|....|....|.. .....|||| .|      ..|..|..| ||.| ..
.....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh

NAPELPREILNIFRVARNSKS-----LVVHCSNGIGRSAAFVSWELCYHFVPVNFEicdfsvaefvyqkmirsldttstvnLDFLSLLTELRHSRPRAIH
..|. ....|...|....|||     .|||||.|.||...||....... .  ...                         .|. ....|||..||....
gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.........................vdifeivkelRkqRpgmvq

TPMQLAFSIMMVLDFV
| .|..| ....|...
tleqYlfiyeaileyi

PTPc_SM00194 945-1252 3.6e-63 208.7 In-house 7-262 (263) alignment
Range on Protein: 945-1252
Range on HMM: 7-262/263.0
LRIANLAPNNAIVESEKYS--EQDRYSDVLCGMDNRILIDEDVCRrcyFKDQYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeee
 .. . .... . |.|| .  ...||...|. ...|. .... ..    ...||||||.... . ...|.||.|.                         
ekleestspketteaekkknksknRyknilpydhtrVklkkeekk...egsdYINAnyikgankkkkyIatQgPl.........................

eisylVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGekKKTHTVKHYSYKGWIEK
      .||..|.............||....|.| |||..|.| |..||..|....|....|.. .....|||| .|      ..|..|..| ||.| ..
.....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh

NAPELPREILNIFRVARNSKS-----LVVHCSNGIGRSAAFVSWELCYHFVPVNFEicdfsvaefvyqkmirsldttstvnLDFLSLLTELRHSRPRAIH
..|. ....|...|....|||     .|||||.|.||...||....... .  ...                         .|. ....|||..||....
gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.........................vdifeivkelRkqRpgmvq

TPMQLAFSIMMVLDFV
| .|..| ....|...
tleqYlfiyeaileyi

0036941 (Phosphotyrosine protein) phosphatases II 931-1260 6.6e-53 175.3 In-house 9-285 (297) alignment
Range on Protein: 931-1260
Range on HMM: 9-285/297.0
KLPLKAMYQFCKSILRIANlAPNNAIVESEKYSEQDRYSDVLCGMDNRILIdEDvcrrcyFKDQYINANYLELPN-GNRMILTQAPMSrtehfkpekdkk
.| |  ... ....|.. .  ..  . ..... | .||.|.|.  ..|. . .|       .. ||||.|..... ....|.||.|..            
llflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.dd......egsdYinAsyvdgydlkrkfIatqgPlp............

rknlyslsdeeeeisylvQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQH-PSADVVLRTLVITSYlgEKKKTH
                  .||..|.. . . ...|. ||... | | ||| .|.|||... ...... |....|.. ...|..|||| .| .  ......
..................ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesr

TVKHYSYKGWIEKNAPELPREILNIFRVARN-------SKSLVVHCSNGIGRSAAFVSWELCYHFVP---VNFEICdfsvaefvyqkmirsldttstvnl
||.|. |.|| . ..|| |...|.... .|.       ..  .||||.|.|||..|.  .|... .     . ...                        
tvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd........................

dFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNFPKGE
 .|... .||. || |. |..|. | ....|...... .| .
.ileavkklReqRpgavqtleqyrflyeallellkkkltkep

0040438 (Phosphotyrosine protein) phosphatases II 953-1266 9.7e-51 168.3 In-house 34-290 (317) alignment
Range on Protein: 953-1266
Range on HMM: 34-290/317.0
NNAIVESEKYSEQDRYSDVLCGMDNRILIDEDVCrrcYFKDQYINANYLELPN-GNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVD
.  . | ..  . .||.|.|.  ..|. .  .     .. . ||||.| . || ....|.||.|.                               .||.
tysvaelpenkdknrypdilpydhsRVkLsplgg...dldsdYInAsyvdgpnlkrkfIatqgPl..............................pntve

KFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELPREIL
.|.. . . |..|. ||... | |.|||  |.||  ......... | ......  |...|||| .. .  ......||.|. |.|| . ..|. |...|
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdlll

NIFRVARN-----SKSLVVHCSNGIGRSAAFVSWELCYHFVPvnfeI----CdfsvaefvyqkmirsldttstvnldFLSLLTELRHSRPRAIHTPMQLA
.... .|.     .. ..||||.|.||...|.  .|... .          .                         . . . |||. || |. ||.|. 
dfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqle....keggvd.........................veeavkelreqRpgavqtpeqyr

FSIMMVLDFVMNNFPKGEMEAKYQ
| ....|...... .. ..  .. 
flydalleylkrkltlepaselkl

0050432 (Phosphotyrosine protein) phosphatases II 912-1256 1.3e-50 167.9 In-house 6-303 (308) alignment
Range on Protein: 912-1256
Range on HMM: 6-303/308.0
KLLNDFMKEEGDKGATNNGKLPLKAMYQFCKSILRIANLA------------PNNAIVESEKYSEQDRYSDVLCGMDNRILIDEDvcrrcyfkDQYINAN
. | ...   ...  ... ||... . ..... | . .|             ..  . . ..  .  ||.|.|.   .|. .||.        . ||||.
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldeg........sdYInAs

YLELP---NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKD-GKQKFHN
|  ..   . ...|.||.|.                               .||..|.. . . ...|. ||... | |.|||  |.||| . | .....
yvdgyssklprkfIatqgPl..............................pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygk

VNVCTTNVQHpSADVVLRTLVITSYLGEkkKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNS---KSLVVHCSNGIGRSAAFVSWELCYHFVPVnfe
. | ......  .|...||| .| . ..  ...||.|. |..| . ..|. |...|.... .|.|   .  |||||.|.||...|.  .|... .     
ftvtllseev.lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlek...

icdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNF
                      . ..|.....  ||. || ...||.|. | ....|..... .
......................eggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl

0039614 (Phosphotyrosine protein) phosphatases II 923-1256 6.6e-48 159.0 In-house 17-293 (297) alignment
Range on Protein: 923-1256
Range on HMM: 17-293/297.0
DKGATNNGKLPLKAMYQFCKSILRIANLAPNNAIVESEKYSEQDRYSDVLCGMDNRILIDedVCRRCYFKDQYINANYLELPN--GNRMILTQAPMSRte
.  .  ....... .... .   .. .| |.  | ....  .  ||.|.|.  ..|. .   ... ... . ||||.|.. ..  ....|.||.|..   
svldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklk..pedgvdldsdYinAsyvdgydlltrkfIatqgPlpe..

hfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVeKCSSYFPLEKDgkqKFHNVNVCTTNVQHpSADVVLRTLVITSy
                            ||..|.. . . |..|. ||....| |. || .|.| | .   ..... | ...|.|  .....||| .|  
............................tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn.

lgeKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVAR-------NSKSLVVHCSNGIGRSAAFVSWELCYHFVPvnfeicdfsvaefvyqkmirsldtt
   .....||.|. | || . ..|.... .|.... .|       ...  .||||.|.||...|.   |... .                          
...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqle.........................

STVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNF
.. ..|.|. . |||  || |. || |. | ....|...... 
keggvdvleavkelreqRpgavqtpsqyrflydallellkrkl

0051299 (Phosphotyrosine protein) phosphatases II 934-1252 1.1e-47 158.3 In-house 25-286 (288) alignment
Range on Protein: 934-1252
Range on HMM: 25-286/288.0
LKAMYQFCKSILRIanlaPNNAIVESEKYSEQDRYSDVLCGMDNRILIDedvCRRCYFKDQYINANYLEL-PNGNRMILTQAPMSrtehfkpekdkkrkn
|.. .. . |.|      ..  .   ... |  ||||.|.  ..|. .        .  . ||||.|... ......|.||.|..               
lleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLs...vldgvegsdYinAsyidgynlkrkfIatqgPlp...............

lyslsdeeeeisylvQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSY--LGEKKKTHTV
               .||..|.. . . ...|. ||... | |.|||  |.||  .|....... |.......  .|...||| .| .  |. .....||
...............ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtv

KHYSYKGWIEKNAPELPREILNIFRVARNS-----KSLVVHCSNGIGRSAAFVSWELCYHFVPvnfeicdfsvaefvyqkmirsldttSTVNLDFLSLLT
.|. |..| . ..|. |...|.. | .|..     .  |||||.|.||...|.  .|... .                           .  .|.|... 
thfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqle.........................keggvdvleavk

ELRHSRPRAIHTPMQLAFSIMMVLDFV
 ||. || .. ||.|. | ....|...
rlreqRpgmvqtpeqyrfvyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 947-1254 1.4e-46 155.0 In-house 36-306 (307) alignment
Range on Protein: 947-1254
Range on HMM: 36-306/307.0
IANL----APNNAIVESEKYSEQDRYSDVLCGMDNRILIDedVCRRCYFKDQYINANYLELP---------NGNRMILTQAPMSRtehfkpekdkkrknl
. ..      .  | ....  .  ||.|.|.  ..|. .   ..   .  . ||||.|  .|         .....|.||.|..                
llsvtvfllgeysiallpenkdknrykdilpydhtRVkls..sldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...............

yslsdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlGEKKKTHTVKHY
               ||..|.. . . |..|. ||... | | |||  |.|.| .... ..|. | .....|  .....||| .| . .......||.|.
...............tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdl.dgtgesrtvthf

SYKGWIEKNAPELPREILNIFRVAR-------NSKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSvaefvyqkmirsldttstvnldFLSLLTE
 |.|| . ..|. . |.|.... .|       ...  .|||| |.||...|.   |... .  . ...|..                      .|. . .
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd......................lleavkl

LRHSRPRAIHTPMQLAFSIMMVLDFVMN
||  || |. .| |. | ....|.....
lreqRpgavqnpeqyrflyeallelllk

0047943 (Phosphotyrosine protein) phosphatases II 952-1252 1.7e-46 154.2 In-house 28-272 (273) alignment
Range on Protein: 952-1252
Range on HMM: 28-272/273.0
PNNAIVESEKYSEQDRYSDVLCGMDNRILIdedvcrrCYFKDQYINANYLELPN-GNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTV
 .  . . ... . .||.|.|.  ..|. .          .. ||||.|....| ....|.||.|.                               .||
ltysvallpenkdknrykdilpydhsrvkl.......gdggsdyinAsyvdgynlkrkfiatqgPl..............................pntv

DKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDG-KQKFHNVNVCTTNVQHpSADVVLRTLVITSYLGEKkkTHTVKHYSYKGWIEKNAPELPRE
..|.. . . ...|. ||... | | |||  |.||| .. ....... | ......  .|...||| .|..  ..  ..||.|. |.|| . ..|. . .
edfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge..srtvthfhytgwpdhgvppsles

ILNIFRVARN-------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLA
.|......|.       ..  |||||.|.||...|.  .|... .                           . ..|.|...  ||  || .. || |. 
llefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlek.........................eggvdvleavkllrsqRpgmvqtpeqyr

FSIMMVLDFV
| ....|...
flyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 953-1256 1.9e-45 150.8 In-house 19-278 (284) alignment
Range on Protein: 953-1256
Range on HMM: 19-278/284.0
NNAIVESEKYSEQDRYSDVLCGMDNRILIDedVCRRCYFKDQYINANYLELP------NGNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisyl
.  .   ... . .||.|.|.  ..|. ..  ..   .  . ||||.|.. .      . ...|.||.|..                             
slsvallpenlsknRykdilpydhsRVklk..sldgdledsdYinAsyvdgydldltyikkkfIatqgPlp.............................

vQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlGEKKKTHTVKHYSYKGWIEKNAPEL
 .||..|.. . . ...|. ||... | |.|||. |.||| ......... | ......   |...||| .| . | .....||.|. |..| . ..|. 
.ntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnl.gytgesrtvthfhytswpdhgvpps

PREILNIFRVARN-------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVNfeicdfsvaefvyqkmirsldtTSTVNLDFLSLLTELRHSRPRAIHTPM
|. .|...| .|.       ..  |||||.|.||...|.  .|... .  .                        ....|.|...  ||  || ...|..
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqleke......................glllgvdvleavkrlreqRpgmvqtle

QLAFSIMMVLDFVMNNF
|. | ....|..... .
qyrfvyealleylklkl

0043336 (Phosphotyrosine protein) phosphatases II 938-1251 1.8e-43 144.4 In-house 23-276 (278) alignment
Range on Protein: 938-1251
Range on HMM: 23-276/278.0
YQFCKSILRIANlaPNNAIVESEKYSEQDRYSDVLCGMDNRILIDEDvcrRCYFKDQYINANYLELPN-GNRMILTQAPMSRtehfkpekdkkrknlysl
..  ...|..    ..  | ....  .  ||.|.|.   .|. .. .      . . ||||.|....| ....|.||.|..                   
llefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsll...ggdldsdYinAsyvdgynvprkfiatqgPlpe..................

sdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGEKKKTHTVKHYSYK
            ||..|.. . . |.... ||... | |..||  |.|   .| ...... | .....|  .|...||| .|     .....|| || |.
............tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtn..lgdgesrtvthyhyl

GWIEKNAPELPREILNIFRVARN-----SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSR
|| . ..|| .  .|.. ...|.     .. ..||||.|.||...|.  .|... .                           . ..|... . |||. |
gwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlek.........................eggvdleeavkelreqR

PRAIHTPMQLAFSIMMVLDF
| |. ||.|. | ....|..
pgavqtpsqyrflyealley

Y_phosphatase Protein-tyrosine phosphatase 964-1249 3.2e-43 143.2 Pfam-A 3-234 (235) alignment
Range on Protein: 964-1249
Range on HMM: 3-234/235.0
EQDRYSDVLCGMDNRILIdedvcRRCYFK-DqYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVDKFYQTIVQTG
.. ||.|.|.  ..|. .     .    . | ||||||...  . ...|.||.|.                               .|...|.. ..|  
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgykekkkfIatQgPl..............................kstiedFWrmvwqek

TEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTT-NVQHPSADVVLRTLVITSYLGEKkKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNS
..|..||.. .|.| |||. |.| |...........| .. ...  .....||.| ...  .|. ....||.. |..| ....|| |...|.. |  ..|
vkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveks

K-----SLVVHCSNGIGRSAAFVSWELCYHFVPV--NFEICDfsvaefvyqkmirsldttstvnldflsLLTELRHSRPRAIHTPMQLAFSIMMVL
|     ..|||||.|.||.. ||. ... . .    ......                           .. |||..|| .. .  |..| ....|
keaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlq...........................ivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 964-1249 3.2e-43 143.2 In-house 3-234 (235) alignment
Range on Protein: 964-1249
Range on HMM: 3-234/235.0
EQDRYSDVLCGMDNRILIdedvcRRCYFK-DqYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVDKFYQTIVQTG
.. ||.|.|.  ..|. .     .    . | ||||||...  . ...|.||.|.                               .|...|.. ..|  
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgykekkkfIatQgPl..............................kstiedFWrmvwqek

TEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTT-NVQHPSADVVLRTLVITSYLGEKkKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNS
..|..||.. .|.| |||. |.| |...........| .. ...  .....||.| ...  .|. ....||.. |..| ....|| |...|.. |  ..|
vkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveks

K-----SLVVHCSNGIGRSAAFVSWELCYHFVPV--NFEICDfsvaefvyqkmirsldttstvnldflsLLTELRHSRPRAIHTPMQLAFSIMMVL
|     ..|||||.|.||.. ||. ... . .    ......                           .. |||..|| .. .  |..| ....|
keaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlq...........................ivkelRkqRpgmvqsleqYiflykail

0045098 (Phosphotyrosine protein) phosphatases II 964-1254 4.9e-43 142.9 In-house 35-274 (278) alignment
Range on Protein: 964-1254
Range on HMM: 35-274/278.0
EQDRYSDVLCGMDNRILidedvcrrcyfkDqYINANYLELPnGNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvQTVDKFYQTIVQTGTE
. .||.|.|.   .|.             | ||||.|.. . ....|.||.|.                               .||..|.... . |..
dknRykdilpydhsrVk............d.YINAsyidgy.pkkfIatqgPlp..............................stvadfwrmlwelgit

VVAMLCDFNEEGVEKCSSYFPlEkDGKQKFHNVNVCTTNVQHPsADVVLRTLVITS--YLGEKKKTHTVKHYSYKGWIEKNAPELP--REILNIFRVAR-
|. ||... | |.|||  |.| | .| . .... |.......   |..|||| .|   .  |  ....|.|. |..| . ..|.||  . .|....  | 
vivmltelvelgrekcaqywp.e.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefire

-----------------NSKSLVVHCSNGIGRSAAFVSWELCYHfvpvnfeicdfsvaefvyqkmirsldttstV---NLDFLSLLTELRHSRPR-AIHT
                 ...  .|||| |.||....|   |...                                  ..|.|. ..|||  ||  |. .
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle..............................lleggvdlleavkelrsqRpglavqn

PMQLAFSIMMVLDFVMN
..|. | ....|.....
leqyrflyefllelllr

0040439 (Phosphotyrosine protein) phosphatases II 963-1254 2.5e-41 137.3 In-house 12-248 (249) alignment
Range on Protein: 963-1254
Range on HMM: 12-248/249.0
SEQDRYSDVLCGMDNRILIdeDVCRRcYFKDQYINANYLELPN-GNRMILTQAPMSRtehfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTG
 . .||.|.|.   .|. .   ...  .| . ||||.|..... ..|.|.||.|..                               ||..|.. . . |
kdknrypdilpydhsrvkl..silpg.lflsdyinAsyidgyyikrrfiatqgPlpe..............................tvedfwrmlwelg

TEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN--
 .|. ||... | | |||  |.||  .| ...... | ...|.. ..|...||| .| .  ......||.|. | .| . ..|. . ..|.... .|.  
itvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkal

-----SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMN
     .. ..||||.|.||...|.   |... .                           . ..|... . .||. || |. .| |. | ....|.....
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlek.........................elgvdleeavkllrsqRpgavqnpeqyrflyeallelllk





0042113 (Phosphotyrosine protein) phosphatases II 964-1252 1.1e-38 128.4 In-house 11-243 (245) alignment
Range on Protein: 964-1252
Range on HMM: 11-243/245.0
EQDRYSDVLCGMDNRILIDEDVCrrcYFKDQYINANYLELPN-GNRMILTQAPMSRtehfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTGT
.  ||||.|.  ..|. . .|      . . ||||.|  ...  ...|.||.|..                               ||..|.. . . | 
dknrysdilpydhtrvklspdgg...dldsdyinasyvdgyritpkfiatqgPlpe..............................tvedfwrmlwelgi

EVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN---
... ||... | | .||  |.||  ......... |......|  .|...||| .|     ......| || | .| . ..|.|.. .|.... .|.   
ttivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkala

---SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFV
   .. ..|||| |.||...|.   |... .                           . .... . . |||  || |. || |. | ....|...
edsngpvlVHCsaGvgRtGtfiaaylmleqlek.........................elgvsleeavkelrsqRpgavqtpsqyrflyeallell

0037934 (Phosphotyrosine protein) phosphatases II 964-1250 3.5e-37 123.7 In-house 12-240 (243) alignment
Range on Protein: 964-1250
Range on HMM: 12-240/243.0
EQDRYSDVLCGMDNRILIdedvcRRcyfkDQYINANYLELPngNRMILTQAPMSRTEhfkpekdkkrknlyslsdeeeeisylvqtvDK----FYQTIVQ
.  ||||.|.  ..|. .           . |||||. . .  .|.|.||.|.. |                               .     |.. . .
sknrysdilpydhsrvkl.....eg....sdyinanliyvt..prliatqgPlpetv..............................eddlasfwrmlwe

TGTEVVAMLCDFNEEGVEKCSSYFPlekdGKQKFHNVNVCTTNVQHPsADVVLRTLVITSyLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN
 |..|. ||... | |.|||  |.|    |.. .... | .....|  .|...|||...  |.... |..| || | .| . ..|. |  .|.... .|.
lgitvivmltelvElgrekcaqywp....gevtygdftvtllseehl.ddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevre

-------------SKSLVVHCSNGIGRSAAFVSWELCYHFVpvnfeicD-FsvaefvyqkmirsldttstvnldFLSLLTELRHSRPR-AIHTPMQLAFS
             .. ..|||| |.||.....   |... .       .                         ... . .||  ||  |. || |. | 
fieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.......gvd.......................leeavkllreqRpgkavqtpsqyrfl

IMMVLD
....| 
yealle

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 990-1188 5.1e-36 119.3 In-house 43-219 (290) alignment
Range on Protein: 990-1188
Range on HMM: 43-219/290.0
YFKDQYINANYLELPNGNRMILTQAPMSRTehfkpekdkkrknlyslsdeeeeISYLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVE----KCSSYFPL
 |.|.|| ||..  ||| |.||||.|  ..                       ..    |. ||. .. |   . | |||.|.|.  .     |. |.| 
rfnddyiHAnrvtcpnglrliltqsPqeki.......................tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

EKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITsYlgEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSK-SLVVHCSNGIGRSAAFVSWELCY
. ... ||....|  ..  .   ||  |.||.. .  .... .||.|. .||| . |..| .. .|.. .  ..||   .||| .|| ||||. . .| |
svgeelkfkgltvkCkskek.eddvetRelvvk.f..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgy

HFVP
  ..
Qkia

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 989-1179 1.3e-24 81.2 In-house 57-240 (302) alignment
Range on Protein: 989-1179
Range on HMM: 57-240/302.0
CYFKDQYINANYLELpNGNRMILTQAPMSRTEHFkpekdkkrknlyslSDEE-EEISYLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEK
  ||...|||| |.| .. . |..| ||  ||.                ...   |    .|..|..  | |  . .|. ||.| |.. .||..|.  . 
vdfkndfinanvlkl.deikwimaqGpmdGtekk..............ekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv

DGKQKFHNVNVCTTNVQHPS------ADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSK-SLVVHCSNGIGRSAAFVS
.|. || .  | | .|..         ...| |. |. .  .||. .||.   . .| .. ||. .   |.|..     | ...||||.|.||. ..|.
ggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlva

subfamily_PTPN12_pd Subfamily PTPN12 1046-1255 3.3e-24 80.3 In-house 92-280 (290) alignment
Range on Protein: 1046-1255
Range on HMM: 92-280/290.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgekKKTHTVKHYSYKGWIEKNAPE
| .|.| |.. | .. .|.| |.|   | |  ||  |.| |.. . .| ...| ... .. . | ..||| ..      |....|. . |. | ... |.
LpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPs

LPREILNIFRVARN-----SKSLVVHCSNGIGRSaafvswelcyhfvpvnfeiCDFSVAEFVYQKMIRsldTTSTVNLDFLSLLTELRHSRPRAIHTPMQ
 . ..|.. . .|.     .. |||||| |.||                        . ..|.. . .    . . .||  .|..|||. |. .. |  |
saksllelielvrelqesedaPlvvhCsaGvGrt...................Gtiiaidyvrellka...ekipeeldvfdlvlelrkqraalvqtkeq

LAFSIMMVLDFVMNN
  .  . |...| ..
yelvykavaelvqke

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1047-1185 1.6e-23 77.8 In-house 104-241 (290) alignment
Range on Protein: 1047-1185
Range on HMM: 104-241/290.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPEL
 .||  ... ..|... .. |||.  |.|  ||. |.| ..     | .. |  .. ... |.....|| .     .. | | .||.  | | .|  .  
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdk..dsGkehklkhlkikswpdksvals

PREILNIFRVARN-SKSLVVHCSNGIGRSAAFVSWELCYH
   .| ..|. |. |  .||||| ||||. .||. | .  
tlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglq

subfamily_PTPRD_pd Subfamily PTPRD 1047-1179 2.2e-23 77.7 In-house 101-233 (564) alignment
Range on Protein: 1047-1179
Range on HMM: 101-233/564.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDgKQKFHNVNVCTTNvQHPSADVVLRTLVItsYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.. | . . .  .... ||   .|.| .||..|.| . . .... .. |  .. ..  ||...||. .     .......|... .  | ....|| 
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtlee.eeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpes

PREILNIFRVARNS-----KSLVVHCSNGIGRSAAFVS
....|.. |  |..     . .|||||.|.||. .|. 
atslLdlirkvralnepdagPivVhCSaGVGRTGtfiv

subfamily_PTPN6_pd Subfamily PTPN6 960-1202 2.7e-23 77.4 In-house 52-269 (306) alignment
Range on Protein: 960-1202
Range on HMM: 52-269/306.0
EKYSEQDRYSDVLCGMDNRILIDedvcRRCYFKDQYINANYLELPNGNRmiltqapmsrtehfkpekdkkrKNLYSLSDeeeeiSYLVQTVDKFYQTIVQ
 .. |..||  .|   ..|. .     .     ..||||||..    .                       .. |  ..       | .||  |.. ..|
penkeknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgs......................dksyiatq.....gclettvsdFWrmvwq

TGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQkFHNVNVCTTNVqHPSADVVLRTLVITSYlGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFR-VAR
  ..|. |.   .| | |||. |.| |.. .. . ...| ...  .  || .||.|...    .||....| .| .| | ... |. |  .|. .. | |
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

NS--------KSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSVAEFV
..         ..|||||.||||  .|.  ..  . .  .   .|. . ..|
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1046-1183 3.5e-23 76.8 In-house 99-237 (301) alignment
Range on Protein: 1046-1183
Range on HMM: 99-237/301.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVV-LRTLVITSyLGEKKKTHTVKHYSYKGWIEKNAP
| .| . |.  .||   | ..||. . |. .|||..|.|..   | .    .. ..| ..   . .  ||| ..    .| .|.|| || |. | ... |
lkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleved.stgkfatrtvthyqysewtdrgvP

ELPREILNIFRVARNS-KSLVVHCSNGIGRSAAFVSWELC
.   |. ..  ....| | .|||||.||||| ||.. |  
kshaelfdlmelvkksekPivvhcsaGiGrsvafigteyl

0041856 (Phosphotyrosine protein) phosphatases II 965-1255 3.6e-22 74.3 In-house 4-174 (182) alignment
Range on Protein: 965-1255
Range on HMM: 4-174/182.0
QDRYSDVLCGMDNRilidedvcrrcyfKDQYINANYLELPNGN-RMILTQAPMSRtehfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTGTE
 .||||.|.   .|                |||||..  .  . |.|.||.|. .                              || .|.... . |  
knrysdilpydhsr.............dldyInanlylgslpatrfiatqgplls..............................tvadflrmlkelgit

VVAMLCdfneegvekCSSYFPlekdgkqkfhnvnvcttnvqhpsadvvlrtlvitsylgeKKKTHTVKHYSYKGWIEKNAPElPREILNIFRVARNS-KS
.. .|.         .  |.|                                       .. .... .| | .|   ..|. ..|.|.. . .... . 
tivnlt.........eelywp.......................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggp

LVVHCSNGIGRSAAFVSWELCYHFvpvnfeicdfsvaefvyqkmirsldttstvNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNN
 .|||| |.||....|   |...                               .... . . ..|  || .. || |. |  ...|......
vlVHCsaGvgRtgtlvaaylmkkl..............................gvsleeavklvrsrRpgmvitpnqyfflqlallellllk

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1046-1180 4.5e-22 73.6 In-house 98-236 (305) alignment
Range on Protein: 1046-1180
Range on HMM: 98-236/305.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYLGeKKKTHTVKHYSYKGWIEKNAPE
| .||. |...||.. .... ||..  |.| .||  |.| .|  |..| ...|  .. ..  .| . | | |.   . .|...|| .|    | ..  |.
lkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiede.dkesrtvlqyqltdWPdhGvpq

LPREILNIFRVARN----S--KSLVVHCSNGIGRSAAFVSW
 .  .|....  ..    .  ..|.||||.|.||. .|.. 
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiav

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1046-1243 4.6e-22 73.4 In-house 82-259 (274) alignment
Range on Protein: 1046-1243
Range on HMM: 82-259/274.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDG--KQKFHNVNVCTTNVQHpSADVVLRTLVITSYLGEKKkthtVKHYSYKGWIEKNA
|..||. |.. | |. ..|. || ...|.  .||. ||| ..|   .... .|.. .... .   |  .|.||. .   |..    |||| |  | ....
lpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekive.rndysvrklvlkylerers....vkhywytdWPdhks

PELPREILNIFRVA------RNSK--SLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAI
|. ....|.. .        .| |  . ||||| ||||  .|.. ... . .                           .  .| |.. ..||  |   .
PddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.........................eivvdvlkivcnlrldrGGmv

HTPMQLAF
.|  |  .
qtseqyel

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 956-1186 1.2e-21 71.9 In-house 14-223 (270) alignment
Range on Protein: 956-1186
Range on HMM: 14-223/270.0
IVESEKYSEQDRYSDVLCGMDNRILIDEDVCrrcYFKDQYINANYLElpngnrmiltqapmsrtehfkpekdkkrknL-------YSLSdeeeeISYLVQ
. |  . .. .|| |.|     |. ..|        . .||||||..                                      |  .      . |  
lpeaargkklnRyadiLPsPatRvrleelee...dsataYinAnyvr..............................GfdgekkkYiaa.....mgPlpt

TVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGEKKKthtVKHYSYKGWIEKNAPELPR
|. .|...|... .. ..|. ...|.| .||. |.| |.. | |... .. ......  ..  ..| .   . ||...   . |. |. | .. .|. . 
tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerr...lvHfwyntWpdhgvpreed

------EILNIFRVARNS-----K--SLVVHCSNGIGRSAAFVSWELCYHF
      ..|...|  |.|     |   |.||||.|.||.  ..  . . . 
sslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrl

subfamily_PTPRB_pd Subfamily PTPRB 1046-1180 4.5e-21 70.1 In-house 103-238 (293) alignment
Range on Protein: 1046-1180
Range on HMM: 103-238/293.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDgKQKFHNVNVCTTNVQHpSADVVLRTLVITSylgeKKKTHTVKHYSYKGWIEKNAPE
| .|||.|.. . .. .... || .  |.| .||  |.| ...  . . ...|  .. ..   | |.|.| |.     .|....|..| .. | . . ||
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeee.ledwvirelkiek....ekeerkvrqyhftsWpdhgvPe

LPREILNIFRVARNSK-------SLVVHCSNGIGRSAAFVSW
 .. .|...|  |...        .||||| |.||. .|.. 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1046-1182 4.7e-21 70.1 In-house 99-234 (288) alignment
Range on Protein: 1046-1182
Range on HMM: 99-234/288.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITsylgEKKKTHTVKHYSYKGWIEKNAPE
| .||..|.. . .. |. ..|| .. |.| .||  |.| ..| .... .|.|  .....   |.|||.| .      ||.  ....| |..| ... ||
ladtvndfWelvyenktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveske.ledfvlrkllle....kkkteleitqyqylaWpdhgvPe

LPREILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWEL
  ...|.. |        ... ..||||.|.||.  |.. . 
skapllellrqvkvanqadtgpiivhCsaGvGrtgtFialda

subfamily_PTPN3_pd Subfamily PTPN3 1046-1193 2e-20 67.9 In-house 93-241 (280) alignment
Range on Protein: 1046-1193
Range on HMM: 93-241/280.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLeKDGKQKFHNVNVCTTNVqHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
| .|. .|.| . .  .... || .  |.|  ||  |.|  .. .... . .|  ..  . .  .||| ||..    |.|. ... .  |  | ... |.
laktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdk..etkeerkilqlqylaWpdhgvPd

LPREILNIFRVARNSK-----SLVVHCSNGIGRSAAFVSWELCYHFVPVNFEI
 . ..|.. .  |. .      .||||| ||||.  ..  |.. . .  . ..
dsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepv

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1046-1178 4e-20 67.3 In-house 108-241 (298) alignment
Range on Protein: 1046-1178
Range on HMM: 108-241/298.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNvQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
|..||  |.. ...   ... || . .| .  |.. |.|  ..||... ...|   . ..  ||.. |.| ....  ...|...|.. ..  | .| .||
ltetvedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvslls.keefadlivrklkvskk..keekerevrqlhftsWpdkgvpe

LPREILNIFRVARN----SK--SLVVHCSNGIGRSAAFV
  . .|.. |  |     ..  ...|.||.|.||| .|.
natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi

0051429 (Phosphotyrosine protein) phosphatases II 1049-1288 6.1e-20 67.5 In-house 34-262 (272) alignment
Range on Protein: 1049-1288
Range on HMM: 34-262/272.0
TVDKFYQTiVQTGTEVVAMLCDFNEEGVEKCSSYFP--------LEKDGKQKFHNVNVCTTNVQH-PSADVVLRTLVITSYLGEKKKtHTVKHYSYKGWI
|.. | .   . |  .. .|.. .| | .||. | |        .. |. .     ... |...     |..||.|..| .|. ..  ..| |. | .|.
taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea.revmhlhytdwp

EKNAPELPreILNIFRVARNSKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSVAEFVyqkmirsldttstvnldFLSLLTELRHSRPRAIHTPM
  ..|. .  .|..... .... ..|||| |..|.. .|   |... |. .  . |.   ..                   .  . |||  || |. |..
dhgvpqea..llellellldggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly.................leeaveelraqrpgavqtee

QLAFSIMMVLDFV--MNNFPKGEMEAKYQEIRKSYLHARQMMHKdLEFDGS
|..|  . .|...  . . .   ..| ...|.. |   .. ... | .. .
qylflyeallellrsllsvraeyllaaldaideeyGsvegYLrd.lglsee

WSN Domain of unknown function 1-58 8.1e-20 60.5 Pfam-A 10-67 (69) alignment
Range on Protein: 1-58
Range on HMM: 10-67/69.0
MQKISRIVNSIYLTAELTAGTANTYDLIAEFFNFGPDSYNKLQSIDMKELKSGLEEIV
...|.|..|.||| |.|. |. . .|.|||..|.|..| ..|..||...||..|... 
lsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls

subfamily_Ptp69D_pd Subfamily Ptp69D 1048-1182 1.1e-19 65.7 In-house 102-241 (307) alignment
Range on Protein: 1048-1182
Range on HMM: 102-241/307.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkdGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYL---GEKKKTHTVKHYSYKGWIEKNAP
.|.. |.. | .   ... || . .|   .||. |.| |   .... ...| . . ..   | . |.| ..      || .... |  |.|.|| . ..|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

ELPREILNIFRVA----RNS-KSLVVHCSNGIGRSAAFVSWEL
| .| .|.. . .    ...   .|||||.| |||. ||. ..
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1046-1179 4.9e-19 63.5 In-house 61-194 (250) alignment
Range on Protein: 1046-1179
Range on HMM: 61-194/250.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEkCSSYFPLEKdgKQKFHNVNVCTTNVQhPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
|..|. .|.. ...  .... || ...|.. . .. |.| ||   .|. .| |   . .   ||.. |.|.....  .|..  .|.....  | .|  ||
lqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyGdvtvsllske.efadytkrklklska..kkaderivrqlhfvvWPdkgvPe

LPREILNIFRVAR-NSK-----SLVVHCSNGIGRSAAFVS
  . .|.. .  . . .      ..|.||.|.||| ||. 
vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafia

subfamily_PTPN1_pd Subfamily PTPN1 1046-1253 5.5e-19 63.0 In-house 80-272 (290) alignment
Range on Protein: 1046-1253
Range on HMM: 80-272/290.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKD-GKQKFHNVNVCTTNVQHPSA-DVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNA
|..||| |.| . .  .  | ||  . |..  || .|.| ...  . .......  . ... .    ..|.| ..    . ..|... |. |  | .   
lpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl..ktqetreilhfhyttwpdfgv

PELPREILNIFRVARNSKSL-------VVHCSNGIGRSAAFVSWELCYhfvpvnfeicdfsvAEfvyqkmIRSLDTTSTVNLDflSLLTELRHSRPRAIH
|| |   |. .   |.| ||       |.||| ||||| .|.  . |               ..      |   | .|.|..     | |||. |   | 
pespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtcl..............vl......iekkddlssvdik..kvllelrkyrlGliq

TPMQLAFSIMMVLDFVM
|. || || . .|. . 
tadqlrfsylaileGak

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1046-1179 1.5e-18 61.7 In-house 100-235 (290) alignment
Range on Protein: 1046-1179
Range on HMM: 100-235/290.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQkFHNVNVCTTNVQHPSaDVVLRTLVITSYLGEkKKTHTVKHYSYKGWIEKNAPE
. .|. .|.. |.|  . .. ||.. .||| .||  |.| . | |. . ....  .| .. . . . |.| ...   . .....|..|  . | ..   .
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierklevknknsa.gakqsvtqyqitnwdstgkvt

LPREILNI-FRVAR-----NSKSLVVHCSNGIGRSAAFVS
 |  || .  .. .       .|.|||||...|||| |..
npqtillvieemyktqrkrgntsivvHCSdtvgrsavfca

subfamily_PTPN13_pd Subfamily PTPN13 1046-1203 7.8e-18 59.7 In-house 86-226 (273) alignment
Range on Protein: 1046-1203
Range on HMM: 86-226/273.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHN-VNVCTTNVQHPSAdVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAP
| .||. |.| . .  .||.||.    |.|  ||  |.| .|. | | .| ..|   .||. ..  |.|.| ..    | .... | |  .  | . . |
lPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldg.fvvralavkds..esgesrevahlnfvkwPdhgvP

ELPREILNIFRVA----RNSKSLVVHCSNGIGRSAAFVSWELCyhfvpvnfeicdfsvaefvY
  . |.|.. .      ...  .||||| ||||| .... .                      
ssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv...................l

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1046-1179 8.3e-18 59.5 In-house 98-232 (318) alignment
Range on Protein: 1046-1179
Range on HMM: 98-232/318.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGEKKKTHTVKHYSYKGWIEKNAPE
| .|.. |.. . . .. |. || . .|.| .|.  |.|  ..| ... .. |  ..  . ..| |||.. .|    |.... .|. | |  | ... ||
lpetieDfWrmvWeqnsavivmltqeeergkakvhryWP..skgsrsygklvvelkeeve.lsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpe

LPREILNIFRVARNS------KSLVVHCSNGIGRSAAFVS
 . ..|.. | ...       . .||||| |.||   |. 
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfia

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1046-1177 8.5e-18 59.4 In-house 91-221 (288) alignment
Range on Protein: 1046-1177
Range on HMM: 91-221/288.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVnvCT-TNVQHPSADVV-LRTLVITSYLGEKKKthTVKHYSYKGWIEKNA
|  |...... ..... | . |||.. | | ||   |||...  | ..  .  || . ...   | .   .|.  |  ||.|.   ||.  .. | ..  
lngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl..ctvvkkkradidklvkvsllriskegeekv..ivkilhlleWdddgv

PELPREILNIFRVARN-SKSLVVHCSNGIGRSAAF
||     |..  | ..  | .|||.|.|.||....
PenylsplrllevlkslqkPivvhssaGvGrtgtl

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1049-1196 9.1e-18 58.9 In-house 93-236 (281) alignment
Range on Protein: 1049-1196
Range on HMM: 93-236/281.0
TVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSAdvVLRTLVITSYLGEkkkTHTVKHYSYKGWIEKNAPELPR
|   |.. | |  |  . |||.| |   |||. ||| .     .| .. |   .     .  .. | .  || ||   |. . |. .| | . . ||   
tradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnks..lvttrlnlsyege...trlithwlwkewpdwqvpesse

EILNIFRVAR-NSKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDF
 .|.|.|  |  |   |.||| |.||| .... |.. . .   | . | 
vmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdi

0036282 (Phosphotyrosine protein) phosphatases II 994-1243 1.1e-17 59.7 In-house 3-161 (174) alignment
Range on Protein: 994-1243
Range on HMM: 3-161/174.0
QYINANYLELPN-GNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvqtvdkFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekdgkqk
 ||||..| |    .| |..|.|..                                   |.. . . | ..| ||.. .| | .||  |.|        
dyinaspldlsyitprliagqgpla...................................fwemlkelgittvvmlleekelglykcinywpe.......

fhnvnvcttnvqhpsadvvlrtlvitsylGEKKKTHTVKHYSYKGWIEKNAPELPReILNIFRVARNS------KSLVVHCSNGIGRSAAFVSWELCYHF
                               .  .... .| | .|   ..|.|.  .|.... ...       . ..|||| |.||....|   |... 
.............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrg

VP---VNFeicdfsvaefvyqkmirsldttstvnldfLSLLTELRHSRPRAIHTPMQLAF
     |.                              |.|. |||  ||... || |. |
lleslvda.............................ldlvrelRlqrpgmvqtpsQyrf

subfamily_PTPN23_pd Subfamily PTPN23 1048-1252 2e-17 58.0 In-house 94-280 (288) alignment
Range on Protein: 1048-1252
Range on HMM: 94-280/288.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELP
.|.  |.. ...  ..|. || . .| | .|...|.| .|.  .|| ...|   .|.. .  .| |.| ..    .......|.|  .. | |  .|. |
stlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletl..dadavksvshlqltsWpelGvPasP

REILNIFRVARN---------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICdfsvaefvyqkmirsldttstvnlDFLSLLTELRHSRPRAIHTP
 ..|... ....          . |||||| |.||. .|       . . ..  .                         | . ..  ||. |   ... 
etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll........................diiqvvsrlreqRrfmvqek

MQLAFSIMMVLDFV
 || ||  .||  .
eqlkfsyeavleaa

0046846 (Phosphotyrosine protein) phosphatases II 1046-1249 2.2e-17 58.8 In-house 32-170 (176) alignment
Range on Protein: 1046-1249
Range on HMM: 32-170/176.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQkfhnvnvcttnvqhpsadvvlrtlvitsylgekkkthtvkHYSYKGWIEKNAPE
|..|. .| . . . | ..| .|..  | |  ||  |.|.... .                                         .| . .| . ..|.
lprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................................qylhlpwpDhgvpd

LpREILNIFRVARNS----KSLVVHCSNGIGRSAAFVSWELCyhfvpvnfeicdfsvaefvyqkmirsldttS-TVNLDFLSLLTELRHSRP-RAIHTPM
| . .|....  |.     .  .|||| ||||....|   |.                                  .|. .  | ..|  || .|. || 
l.elllellefirealkeggpvlVHCsaGigRtgtlvaayll..............................elekglsveealalvreqRplgavqtpe

QLAFSIMMVL
|. |  ...|
Qyrflyefel

subfamily_PTPRN_pd Subfamily PTPRN 1046-1182 2.5e-17 57.6 In-house 109-246 (297) alignment
Range on Protein: 1046-1182
Range on HMM: 109-246/297.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkdGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
| .|| .|.|.. . |. |. .|.  .||||..|. |.| |  |.. .|  .|        . | ..|.. .     ....| ||  . .  | |...| 
lastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvrsfylknl..qtsetrtvtqfhflswpeegvPa

LPREILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWEL
 .. .|.  |         | ..|||||.| ||. ...  .|
saksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl

subfamily_PTPRK_pd Subfamily PTPRK 1047-1182 3.2e-17 57.3 In-house 96-232 (314) alignment
Range on Protein: 1047-1182
Range on HMM: 96-232/314.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQkFHNVNVCTTNVQhPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .||  |.. . . ..  . || .. |.|  ||. |.|  .|... . ...|   ... . |..| |.. ..     ......|... . || . . |  
qetvkdfWrlvydencasivmltelvevgrvkClkyWP..edtev.ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs

PREILNIFRVARN-----SKSLVVHCSNGIGRSAAFVSWEL
 . .|.. |   .        .|||||.| ||. .|.  . 
atgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

PTPc_DSPc_SM00012 1129-1249 4.3e-17 57.6 In-house 1-104 (105) alignment
Range on Protein: 1129-1249
Range on HMM: 1-104/105.0
TVKHYSYKGWIEKNAPELPREILNIFRVARNSK-------SLVVHCSNGIGRSAAFVSWELCYHFVPVNFeicdfsvaefvyqkmirsldttstVNLDFL
||||| |.|| ....|| . .||...|  ...|       ..|||||.|.||.. ||  ..... .  .                          ..|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket........................kevdif

SLLTELRHSRPRAIHTPMQLAFSIMMVL
 .. |||..||... | .|  | ....|
qivkelrkqRpgmvqteeqylflyrall

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1046-1183 5.4e-17 56.4 In-house 105-244 (305) alignment
Range on Protein: 1046-1183
Range on HMM: 105-244/305.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNV----NVCTTNVQHPSADVVLRTLVItSYLGEKkkTHTVKHYSYKGWIEK
| ||.|.|.  ..|   | . |||   | |  ||. |.|. .  |.....     ||  ..  .  |.. . .| . .| |..  . .|.|  .  | ..
ldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnl.tysgdq..kmsvrhlqwtewpdr

NAPELPREILNIFRVARNSK-SLVVHCSNGIGRSAAFVSWELC
  |      |...   | ||  .||||| ||||. . |. |  
gvppckltslellsairgskvpivvhcsagigrtgtivaieyi

0043147 (Phosphotyrosine protein) phosphatases II 994-1244 5.6e-17 57.5 In-house 6-153 (172) alignment
Range on Protein: 994-1244
Range on HMM: 6-153/172.0
QYINANYLELPNG-NRMILTQAPmsrtehfkpekdkkrknlyslsdeeeeisyLVQTVDKFYQTIVQTGTEVVAMLCDFneegvekcssyfplekdgkqk
 ||||.||.|.   .| | ||.|                              |  |...|.. . . |  .. .|...                     
dyinasyldlyyipdrfiatqgp..............................lrntladfwrmlkelgithivnltel.....................

fhnvnvcttnvqhpsadvvlrtlvitsYLGEKKKTHTVKHYSYKGWIEKNAPeLPREILNIFRVARN------SKSLVVHCSNGIGRSAAFVSWELCYhf
                           ..  .. .... .| | .|   ..| |.. .|....  ..      ..  .|||| |.||....|   |..  
...........................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml..

vpvnfeiCDFsvaefvyqkmirsldttstvnlDFLSLLTELRHSRPRAIHTPMQLAFS
       ...                      ...  . ..|. || |. .| |. | 
.......lgl......................sleeavalvrekRpgavqnpsqyrfl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 952-1179 9.6e-17 55.8 In-house 23-218 (283) alignment
Range on Protein: 952-1179
Range on HMM: 23-218/283.0
PNNAIVESEKYSEQDRYSDVLCGMDNRILIDEDVCrrcyfkdQYINANYLELpngnrmiltqapmsrtehfkpEKDKKRKNLYSLSDeeeeiSYLVQTVD
 .  |  ...  ...|. ...    .|. .. .         .|||| .. .                     .|..|... |  .      | | .|| 
ldadiasadenkrknrnqeivpadqwrvelksesr.......dyinavfipv.....................sksykqdkkyiiaq.....sPldrtvv

KFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNvQHPSADVVLRTLVITsYLGEKKKTHTVKHYSYKGWIEKNAPELPREIL
 |.. . .     . ||  . |.  .||| |.|  |.| ... .  |   . .  |   . . |..  . .  |.|  . || . .|.| .       ..
dfWkmvfdekitaivmltklqedlrikCsqyWP..krGsedyGeftvtlrk.ettsnsfiikelllr.vnssakstlllahyqvidWleygeqaiinslv

--N-IFRVARNSK--SLVVHCSNGIGRSAAFVS
  | .    ..||   .|||||.||||.|.|..
kfnkvislqteskkgPivvhCstgiGrtavfia

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1048-1181 9.7e-17 55.6 In-house 99-240 (305) alignment
Range on Protein: 1048-1181
Range on HMM: 99-240/305.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHN----VNV-----CTTNVQHPSADVVLRTLVITSYLGEkkKTHTVKHYSYKGW
.|   |.   .|   | . |||.. | | .||. ||. ... . .|..    . |      | . ..... .| .| ..    ||  |.. |.|| .  |
ktcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpge..karkvthyhwidw

IEKNAPELPREILNIFRVARNSKS-LVVHCSNGIGRSAAFVSWE
 ..  |     ||...  || ||  .||||| ||||. . |  |
pdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmle

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1048-1181 1.4e-16 55.4 In-house 93-230 (307) alignment
Range on Protein: 1048-1181
Range on HMM: 93-230/307.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHN----VNVCTTNVQHPSADVVLRtLVITSYLGEKKKTHTVKHYSYKGWIEKNA
.|. .|.  ..|   | | |||.  | .  ||  |.|||.  |. | .    ..|    ... . |  |   | |  .   .|. |..|. .. | .. .
ntqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgv

PELPREILNIFRVAR-NSKSLVVHCSNGIGRSAAFVSWE
|..    .|..   | .   .||||| |.||| . |.  
pqinltainlleavrydtnpvvvhcsaGvGrsGtivais

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1048-1181 1.5e-16 55.4 In-house 95-229 (281) alignment
Range on Protein: 1048-1181
Range on HMM: 95-229/281.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylgEKKKTHTVKHYSYKGWIEKNAPELP
.....|.| ....  ....|.    |.|  ||  |.| ... . |. .| | .|. .. .|  . |.. ..    |. .| .|..  |. | .. .|. .
aslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeee.katyierkfkler...esgetreveqlaytaWPdhGvPatt

REILNIFRVA----R--NSKSLVVHCSNGIGRSAAFVSWE
.|.|.  .      .  .  .||.||| |.||. .... .
kellefrkevlkltekktkaplvihCsaGvGrtGtyialD

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1047-1179 2.8e-16 54.5 In-house 101-235 (319) alignment
Range on Protein: 1047-1179
Range on HMM: 101-235/319.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKdgKQKFHNVnVCTTNVQHPSADVVLRTLVItSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.. |.. . . .. .| ||.. .|..  |.. |.| |.   ... .. . | . ..  .|.. | | .   . .. .| .|||. |. | ... || 
entiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrl.ivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPek

PREILNIFRVARNSKSL------VVHCSNGIGRSAAFVS
 . .|....  |.|..       |||||.|.||  .|. 
atslldllkrirksrektqsgPivvhCsaGvGRtGtfiv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1046-1180 3.8e-16 53.9 In-house 95-231 (287) alignment
Range on Protein: 1046-1180
Range on HMM: 95-231/287.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDgkQKFHNVNVCTTNVQhPSADVVLRTLVITSYlGEKKKTHTVKHYSYKGWIEKN-AP
...|. .|.. | .   ... |||. .|.  |.|  |.| ||     . . |.  .| .  .|... |.| ..   ........|| | .  | ..   .
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknk.nkagdkqqvkqyqitnWdstgkvt

ELPREILNIFRVARNS-----KSLVVHCSNGIGRSAAFVSW
|    .| | .  ..       |.|||||...|||| |.. 
epqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaa

subfamily_PTPRA_pd Subfamily PTPRA 1047-1181 7.6e-16 52.9 In-house 111-249 (330) alignment
Range on Protein: 1047-1181
Range on HMM: 111-249/330.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNVQHpSADVVLRTLVIT--SYLGEKKKTHTVKHYSYKGWIEKNAP
 .||. |.. | .  .  . || ...|   |||  |.|  ..|   . |..|.  ...  . |. .| ....  .   ..||.  |. . ...| .   |
eetvedfwrmiweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetv.lvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

ELPREILNIFRVARN-----SKSLVVHCSNGIGRSAAFVSWE
  |. .|....  ..     . ..||||| |.||. .|.  .
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1048-1183 1.5e-15 52.1 In-house 103-240 (297) alignment
Range on Protein: 1048-1183
Range on HMM: 103-240/297.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVeKCSSYFPleKDGKQKFHNVNVCTTNVQHPSaDVVLRTLVITSylGEKKKTHTVKHYSYKGWIEKNAPE--
.||. |.. ...  . ...|| | ||.   ||  |..  ..| ..| .| | .. |.. .   . |.|..|   |. |... || | .  | .|. ..  
atvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvttfGdvsvvllsvsere.Gfikrelevtk..gkakarrvvkqyqfveWPdkaverkd

LPREILNIFRVAR------NSKSLVVHCSNGIGRSAAFVSWELC
  . .|..    |      ..  |.|||..|.|| . ... . .
sassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

0049260 (Phosphotyrosine protein) phosphatases II 1047-1243 1.7e-15 52.5 In-house 19-141 (152) alignment
Range on Protein: 1047-1243
Range on HMM: 19-141/152.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFplekdgkqkfhnvnvcttnvqhpsadvvlrtlvitsylgekkkthtvkHYSYKGWIEKNAPEL
 .|...|.. . . |  .. ||... | | .||  |.                                                .| .  |   ..|.|
pntladfwrmlkelgittivmltellelgklkceqyi................................................qylhlpwpDhgvpdl

PREILNIFRV-----ARNSKSLVVHCSNGIGRSAAFVSWELCYhfvpVNfeicdfsvaefvyqkmirsldttstvnLDFLSLLTELRHSRPRAIHTPMQL
.  .| ....      ....  .|||| |.||....|   |..     .                           ....  .  .|  || |. .| ||
sqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml....lg...........................vsleeavalvrekRpgavpnpgql

AF
 |
rf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1046-1181 2.9e-15 51.0 In-house 84-224 (285) alignment
Range on Protein: 1046-1181
Range on HMM: 84-224/285.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHP-SADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAP
| .|.  |.. | |     | ||| . | |||||. |.| .     || . ..  |...    |  .| .| ..       .   ..|     | .. ||
lpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlap

ELPREILNIFR----VARNSKSLVVHCSNGIGRSAAFVSWE
|  | ......    |  . | ..|||| |.||.|.||  .
edarpmielykwvkkvnpkekpicvhcsagvgrtatfvgid

subfamily_PTPRG_pd Subfamily PTPRG 1046-1178 3.8e-15 50.1 In-house 100-238 (563) alignment
Range on Protein: 1046-1178
Range on HMM: 100-238/563.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHPSAdVVLRTLVITSYLGEKKKT----HTVKHYSYKGWIEK
| .|.| |.. | .  .... |. ...|.| .||  |.|   |. ... ...|  .. .. .     |||||     .|||     ..|..| |  | ..
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

NAPELPREILNIFRVARNSK-S----LVVHCSNGIGRSAAFV
..|| .   |.  . .  .. .    .|||||.|.||.  ..
gvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi

0051082 (Phosphotyrosine protein) phosphatases II 994-1207 4e-15 51.2 In-house 4-119 (151) alignment
Range on Protein: 994-1207
Range on HMM: 4-119/151.0
QYINANYLElpngNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvqtvdKFYQTIVQTGTEVVAMLCDFNEEGveKCSSYFPLEKdgkqkf
 |||..|..    ........|..                                   |.... . |  .. .|..  | |  .| .|.| .       
dyinfsyvt....gglyrsggpla..................................dflellkelgiktivnlrseeerg..ycpeylpelg......

hnvnvcttnvqhpsadvvlrtlvitsylgekkktHTVKHYSYKGWIEKNAPELPREILNIFRVARN--SKSLVVHCSNGIGRSAAFVSWELCYHFvpvnf
                                  ..|.|. . .| . . |... ..|........  .. ..|||| |.||....|   |...      
..................................ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.....

eicdfsvaefvyqkmI
               .
...............v

subfamily_PTPN9_pd Subfamily PTPN9 1046-1184 6.4e-15 49.9 In-house 94-247 (297) alignment
Range on Protein: 1046-1184
Range on HMM: 94-247/297.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
| .||. |.. . .  . |. |   . |.|  ||. |.|||..  ..| ...| . .|.. . | . |.|.|.    ..... .| |. . .| .   |.
lkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknv..kteesrkvthfqflsWPdyGvPs

LPREILNIFRVARNSKS------------------LVVHCSNGIGRSAAFVSWELCY
   ..|.. ...|. ..                  .||||| ||||. .|.. ..| 
saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldicl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1048-1183 8.1e-15 49.5 In-house 98-233 (315) alignment
Range on Protein: 1048-1183
Range on HMM: 98-233/315.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQhPSADVVLRTLVITsylgEKKKTHTVKHYSYKGWIEKNAPELP
 .|| |.. ..|. .  ..|. . .|.   ||  |.| .|    .| ...| . ... . .| | | ||.     . ....||  . ...| .| ...  
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsle.adtdgvarklvtr....kseesrtvtqfqftewPdkGvdkqt

REILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWELC
  .|.. .  .     .  ||.|||| |.||.  ..| . .
ssllklikevkadngkkefsllvhcsaGvGrtGvvisidev

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1048-1183 1.1e-14 48.4 In-house 97-232 (515) alignment
Range on Protein: 1048-1183
Range on HMM: 97-232/515.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGEKkkTHTVKHYSYKGWIEKNAPELP
 .|| |.. ..|  .  .||. . .|.   ||. |.|       || ...| .  ..   .. . |.| ..   |..  ..||  . ...| .| .|.  
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea.ctggikrkltvlk..gdd..srtvtqfhfteWPdkGvpkht

REILNIFRVARNS-----KSLVVHCSNGIGRSAAFVSWELC
. .| . .  . .      .|..||| |.||   ..| . .
ssllklikevkadhgqythpliihcsaGvGrtGvvisidsv

subfamily_PTPN14_pd Subfamily PTPN14 1047-1183 1.9e-14 48.4 In-house 103-252 (300) alignment
Range on Protein: 1047-1183
Range on HMM: 103-252/300.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLE--KDGKQKFHNVNVCTTnVQHPSADVVLRTLVITSYLGekKKTHTVKHYSYKGWIEKNAP
 .|| .|.| . ..|.....|| . .|.| ||. .||| .  |  . .| . .| |   .. |  |. ..| .   .   |.  || |  |. | ... |
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttk.fsedsdsvittglklkhlps..keertvwhlqytDWpdhgvP

ELPREILNIF------RVARNSKS--------LVVHCSNGIGRSAAFVSWELC
| ... |.        | . ||..        ..||||.|.||.   .  .| 
eDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1048-1181 9.3e-14 46.4 In-house 115-245 (319) alignment
Range on Protein: 1048-1181
Range on HMM: 115-245/319.0
QTVDKFYQTIVQTGTEVVAMLCdfneegVEKCSSYFPLEKDGKQKFHNVNVctTNVQHpSADVVLRTLVItSYLGEKKKTHTVKHYSYKGWIEKNAPELP
 |.. |.. | .  .  . .|        .||| |.||. . |..  .|.|  . |.  .|. |.| . . |  |..|    .. . ..|| ..  |. |
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkv..dsvee.taeyvvrdiel.sedgkekdirkitqfhflGwpdvGvpdyp

REILNIFRV-------ARNSKSLVVHCSNGIGRSAAFVSWE
 ... . .         .. ...||||| |.||. ...  .
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1048-1181 1.1e-13 46.3 In-house 79-209 (284) alignment
Range on Protein: 1048-1181
Range on HMM: 79-209/284.0
QTVDKFYQTIVQTGTEVVAMLCdfneegVEKCSSYFPLEKDGKQKFHNVNVctTNVQHpSADVVLRTLVItSYLGEKKKTHTVKHYSYKGWIEKNAPELP
 |.. |.. | .  .  . .|        .||| |.||. . |..  .|.|  . |.  |.. |.| . . |  |..|.  ... . ..|| ..  |. |
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkv..dsvee.seeyvvrdiel.sedgkekdirkirqfhflgwpdvgvpdyp

REILNIFRV-------ARNSKSLVVHCSNGIGRSAAFVSWE
 ... . .         .. ...||||| |.||. ...  .
sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1047-1180 3.6e-13 44.3 In-house 101-241 (325) alignment
Range on Protein: 1047-1180
Range on HMM: 101-241/325.0
VQTVDKFYQTIVQTGTEVVAMLCDFnEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPsADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPEL
 .|.. ... ...  . || .|  . ..| ..|. |.| |    ..|  ..|    ...  .| | | | .     .| .| .|| . ...| .   .. 
tatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqv..kkGetrsvkqfqlqswddmGvqkr

PREILNIFRV-----------ARNSKSLVVHCSNGIGRSAAFVSW
|  ...| ..           .. |  ..||||.|.||. .|.| 
patlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl

0044763 (Phosphotyrosine protein) phosphatases II 1051-1242 4.3e-12 41.5 In-house 38-161 (178) alignment
Range on Protein: 1051-1242
Range on HMM: 38-161/178.0
DKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDgkqkfhnvnvcttnvqhpsadvvlrtlvitsylgekkkthtvKHYSYKGWIEKNAPELPREI
 .... . . |  .. .|..  | | .||  |.| | .                                           .| . ..   ..|.|.. .
addlellkelgithivnlteelelgflkcdpywpeeag..........................................iqylhipipDhgvpdllehf

LNIFRVA-----RNSKSLVVHCSNGIGRSAAFVSWELCYHFvpvnfeicdfsvaefvyqkmirsldttstvNLDFLSLLTELRHSRPrAIHTPMQLA
|....       .. .  .|||| |.|||...|   |....                              .|.. . . ..|  || .. .| || 
lefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl..............................glsleeaielvrerRp.ivpnpgqlr

0048076 (Phosphotyrosine protein) phosphatases II 1116-1245 8.3e-12 40.5 In-house 33-136 (145) alignment
Range on Protein: 1116-1245
Range on HMM: 33-136/145.0
VITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN----SKSLVVHCSNGIGRSAAFVSWELCYHfvpvnfeicdfsvaefvyqkmirsld
|..    ..  .... .| | .|   ..|.|.. .|....  ..     .  .|||| |.||....|   |...                          
vlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll..........................

ttstVNLDFLSLLTELRHSRPRAIHTPMQLAFSI
     .... . | ..|  || |. .| || | .
....lgvsleealelvrsqrpgavpnpgqlrfly

subfamily_CG42327_pd Subfamily CG42327 1048-1173 2.7e-11 37.7 In-house 83-207 (319) alignment
Range on Protein: 1048-1173
Range on HMM: 83-207/319.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEK--DGKQKFHNVNVcTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYkGWIEKNAPE
..  .|..|. .  . |.  |.|  | |...|. |.| ..  |... . .. | |   .      .. ||..     .|...  . || |  |.| . | 
dsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilv.tlkgrevkdryaistlllkrv..dkeesrelthywy.kwleaevPa

LPREILNIFRVARNS-KSLVVHCSNGIGR
 .. .. ..  .|.| ||  .. .| .  
eeaaliamllevrsslksysleqanelre

0049772 (Phosphotyrosine protein) phosphatases II 964-1245 4.4e-11 38.5 In-house 48-273 (314) alignment
Range on Protein: 964-1245
Range on HMM: 48-273/314.0
EQDRYSDVLCGMdNRILIDedvcRRCYFKDQYINANYLELPngNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvQTVDKF----------
. .|| |.|.   ||  ..    .  ..   ||||.|.  .  .. | ||.|..                               ||. |          
dknryldilpad.nrvilp....glpvsgsdyinasyvdgf..lkfIatqgple..............................itvvdfreepvlyyng

YQTIV--QTGTEVVAM---------------------LCDFNEEGvekcssyfplE----------KdgkqkfhnvnvcttnvqhpsadvvlrtlvITSY
.. ..  .  . .. |                     |... . |                     |                                |
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..........neptaadlellk.............................eely

LGEKKKTHTVKHYSYkGWIEKNAPeLPREILNIFRVAR---NSKSLVVHCSNGIGRSA-AFVSWELCYHFvpvNfeicdfsvaefvyqkmirsldttstv
 .|. . . .|.. .  .   .|| |.. .. .... .   . . ..|||. |.||.. . |   |....   .                          
dpelferlgikylri.pvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...g..........................

nLDFLSLLTELRHSRP-----RAIHTPMQLAFSI
 ...   | ..|  ||     ..|....|. |  
.vsleealedvrlkRpinpnpgfieqleqyefil

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1048-1179 4.4e-11 37.4 In-house 56-191 (237) alignment
Range on Protein: 1048-1179
Range on HMM: 56-191/237.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNvQHPSADVVLRTLVITSyLGEKKKTHTVKHYSYKGWIEKNAPELP
 . | |.| . |    |. ||  . |   .||  |.| . |  . .  . |  .  .   .|  .|.|...   ...|.   .. | .  | ..  |.  
sscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaaygvltvslkk.keefsdytvrslllsk.rltlkevrlihqyqftswpdrgvpqqt

R-------EILNIFRVARNSKSLVVHCSNGIGRSAAFVS
        .|.|  .   .|   ..||| |.||.. |. 
aallrfrkniinrsphvsesgpwiihcsagvgrtgiflv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1033-1144 5.4e-11 36.9 In-house 66-180 (297) alignment
Range on Protein: 1033-1144
Range on HMM: 66-180/297.0
LYSLSDEEEEISYL------VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCttNVQHPSADvvLRTLVIT-SYLGEKK
   . |||... |.       .||| |.. ... .  |..|.. ..|.| .||  |.|  .....|  .| |    . . | .    ....|   |  ..
yvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvve..flsstsde..fdrviltelqliyrs

KTHTVKHYSYKGWIEKNAP
..  |.|  . .| ..  |
esrvvrhvqflswpdhGvp

0048179 (Phosphotyrosine protein) phosphatases II 1127-1243 6.3e-11 37.7 In-house 46-136 (144) alignment
Range on Protein: 1127-1243
Range on HMM: 46-136/144.0
THTVKHYSYKGWIEKNAPELPREILNIFRVARN----SKSLVVHCSNGIGRSAAFVSWELCYhfvpvnfeicdfsvaefvyqkmirsldttsTVNLDFLS
.... .| . .|   ..|.|.  .|....  ..    ..  .|||| |.||....|   |..                              . .|.. .
eregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk..............................klglslee

LLTELRHSRPRAIHTPMQLAF
 | ..|  || |. .| || |
alalvrsrrpgavpnpgqlrf

subfamily_CG7180_pd Subfamily CG7180 1048-1192 8.9e-11 36.0 In-house 96-255 (296) alignment
Range on Protein: 1048-1192
Range on HMM: 96-255/296.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVeKCSSYFPLEKdgKQKFHNVNVCTTNVQHpSADVVLRTLVITSY--------LGEKKKTHTVKHYSYKGWI
.|||.|.. . . ... | .|..  .    .. ||.| .   |... .. | ......  |... ||. .|           ..| .| .||.. .. | 
etvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekq.yanlkirtfkltkkivalteqekqvkaetRivklfqlteWe

E-KNAPELPREILNIFRVARN----------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFE
  .. |     .... | .|            . .||..|.| .|| .... . .   |  . |
ledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeee

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1050-1179 9.3e-11 36.3 In-house 64-192 (239) alignment
Range on Protein: 1050-1179
Range on HMM: 64-192/239.0
VDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlekDGKQKFHNVNVCTTNVqHPSADVVLRTLVItSYLGEKKKtHTVKHYSYKGWIEKNAPELPRE
   |.. . |    |. ||  . |   .||  |.|   |   |. |. |   .     || ..||.|. | .|. .. . | .| .  | .|  |.    
sgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrkt.evfadyiirtfvm.sqvgqtee.ryvyqyhftvwpdkgvpqyata

ILNIFRV-ARN----SKSLVVHCSNGIGRSAAFVS
.| . |  ...    ..  |.||| |.||. ||. 
vlglrrkitkdslpgarpwvihcsagvgrtgaflv

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1050-1179 1.1e-10 36.1 In-house 65-193 (239) alignment
Range on Protein: 1050-1179
Range on HMM: 65-193/239.0
VDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlekDGKQKFHNVNVCTTNVqHPSADVVLRTLVItSYLGEKKKtHTVKHYSYKGWIEKNAPELPRE
   |.. . |    |. ||  . |   .||  |.|   |   |. |. |   .     || ..||.|. | .|. .. . | .| .  | .|  |.    
sgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrkt.evfadyiirtfvm.sqvgqtee.ryvyqyhftvwpdkgvpqyata

ILNIFRV-ARN----SKSLVVHCSNGIGRSAAFVS
.| . |  ...    ..  |.||| |.||. ||. 
vlglrrkitkdslpgarpwvihcsagvgrtgaflv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1046-1185 7.3e-10 33.3 In-house 101-237 (315) alignment
Range on Protein: 1046-1185
Range on HMM: 101-237/315.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkdgKQKFHNVNVCTTNVQHpSADVVLRTLVITSylgeKKKTHTVKHYSYKGWIEKNAPE
.|..|. |.. . .     . || .  |.  .|.  |.| .   |  . .. |   . ..   ..  ||| ...    ... ..|  . |  | . . |.
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseev.nteytvrtlsvvf....gdnirevvqlhytswpdmgvpk

LPREILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWELCYH
    ..|..| ..     .  ..|||||.|.||. .|.. .   .
ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1047-1182 7.5e-10 33.3 In-house 14-156 (198) alignment
Range on Protein: 1047-1182
Range on HMM: 14-156/198.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQhPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.  |.| . .||.  . |. | . .     . |.|  . |  |. ...|.|  .    .| .. .|..|.       |  . || .  | || .|..
retladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnv

P---------REILNIFRVARNsKSLVVHCSNGIGRSAAFVSWEL
          ||. . .   ..   ..||||.| | .  ||. ..
alfvgfvvasrevskkyeqekd.apvivhcsdgqgftgvfvaldi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1047-1182 7.8e-10 33.2 In-house 15-157 (199) alignment
Range on Protein: 1047-1182
Range on HMM: 15-157/199.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQhPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.  |.| . .||.  . |. | . .     . |.|  . |  |. ...|.|  .    .| .. .|..|.       |  . || .  | || .|..
retmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnv

P---------REILNIFRVARNsKSLVVHCSNGIGRSAAFVSWEL
          ||. . .   ..   ..||||.| | .  ||. ..
alfvgfvvasrevskkyeqekd.apvivhcsdgqgftgvfvaldi

subfamily_eak_pd Subfamily eak 1050-1258 7.8e-10 32.6 In-house 106-311 (332) alignment
Range on Protein: 1050-1258
Range on HMM: 106-311/332.0
VDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGekKKTHTVKHYSYKGWIEKNAPELpRE
|  |.| ...  .  . .| .  |...||   ||| .   . ||  ..| . .  .  . .  | |...   |   .|| |.|| . || | . | . ..
vfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvk.rniletrllelsk..G..nethrvlhykvfGwtettlpky.ed

ILNIFRVARNSKSLVVHCSngigRSAAFVSWELCYHFVP-VNFEICDFSV-----AEF-VYQKMIRSLDTTSTVNLDFLSLLTELRHSRPRAIHTPMQLA
 | ...| ..   | .       .|| . |    |.  |  .  |   .        | | . .|| .|   .       |.   .. |  .. . .| .
flalrkvmkevGvlllivm....ksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhs

FSIMMVLDFVMNNFPK
|   .|||....  ..
fiyeivldyllrrnnr

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1046-1183 8.5e-10 32.9 In-house 89-233 (287) alignment
Range on Protein: 1046-1183
Range on HMM: 89-233/287.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAP-
.  || .|.. ...| . .|...    ||.  ||  |.| |..   .     |   . .  . .   |.| .     | .... || . .  | .| .. 
iaatvrdfwravletrsasvitmtreveearlkcykywP.erevPmrvGGysvvlldydikePeygvralrlidl..etrearvvkqldllswPdkvlaP

E---LPREILNI------FRVARNSKSLVVHCSNGIGRSAAFVSWELC
    | | .|..       | | .   ||||.. |||||  ...   .
tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl

subfamily_egg_pd Subfamily egg 1047-1183 7.6e-09 29.7 In-house 93-224 (307) alignment
Range on Protein: 1047-1183
Range on HMM: 93-224/307.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEgvEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGEKKKTHTVKHYSYKgWieKNAPEL
  ||| |.. . |   . . ||    |   |.|  |.|  ..   ..   ..  .|..  |.   | ..     .| ...   ..|. .  .  .|. ..
kntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.v..nnssdv

pREILNIFRVARN-SKSLVVHCSNGIGRSAAFVSWELC
    |...| .|| ||  ||.. .|. ..|..|. |. 
.ysplrvlrklrnlskpvvvqdilGvskaatlvaieia

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1046-1180 9.2e-09 29.4 In-house 94-246 (301) alignment
Range on Protein: 1046-1180
Range on HMM: 94-246/301.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQ-HPsaDVVLRTLVITSYLGEK-------------KKTHTVK
. .|.  |.. |.|  .  . |... .|.  .||  |.|  .  ...| ...|  .| | .|  | |.| | .. . | .             |....| 
mkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyP..dfvirqlnvkiqdgsnngyierkfkvksdksswdvl

HYSYKGWIEKNAPELPREILNI-----FRVARNSK-SLVVHCSNGIGRSAAFVSW
 .    | .      || .|..      |  . ..  .|||||....||  ..| 
qlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1047-1178 1.3e-08 28.9 In-house 92-227 (312) alignment
Range on Protein: 1047-1178
Range on HMM: 92-227/312.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQK--FHN--VNVCT-TNVQHPSADVVLRTlVITSYLGEKKKTHTVKHYSYKGWIEK
 .|. .|.|  .  |.  . .|| | |.| |||. |   .  |  .   |    . ||  ..   | | .    |.   .    .   ..|| .  | ..
entcthfwqlalslgstsiillcgfvedgsekcakyis.divgfvdledhrvyteycteieiggkskdkithr.vlkvvvkatgqesklnhyqwaswpdh

NAPELPREILNIFR-VARNSKSLVVHCSNGIGRSAAFV
  |.     | ..  | .. | .. ||| |.||. ...
gmpdscdtalrllsavkkdkkpviahcsagvgrtgtla

MutS_III MutS domain III 116-255 3e-07 17.8 Pfam-A 48-150 (204) alignment
Range on Protein: 116-255
Range on HMM: 48-150/204.0
DTAGIEEFQNAVKNFIG-AAADVEKYSNLEKLTDVDIMYARplIYTLKTSIENLAKSYSSINSFDDFekirnpsefvdpiskivsgykkynasrttierd
| | |.. ..||. ...  |.  .  . |.|| |.. . .|  ... . |.. |.. .|........                                 
diaeinaRldaveallenealredlreaLkklpDlerllsr..lalgrasprdllalrstlkalpel.................................

gnfAKGMQSNANNMKRLENVASVFEGLGSFVKNLQAVIDVR
   .| ..|. . |. ||...| .. | ...| |. .|| .
...kklesselesmelleallsklnpleellklledaided

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1046-1179 3e-07 24.7 In-house 81-211 (267) alignment
Range on Protein: 1046-1179
Range on HMM: 81-211/267.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEgveKCSSYFPLEKDGKQKFHNVNVCTtNVQHPSADVVLRTLVITsYlgEKKKTHTVKHYSYKGW-IEK-NA
| .|. .|.. | . .  |. .|    ..   .   ..| .    .|.... |   ....   |  . || .  .  ... .| |  | || | |.  | 
lkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltveh.slekeendyqiitlelk.f..knesahnvtlyyykkwnintnnk

PELPR--EILNIFRVARNSKSLVVHCSNGIGRSAAFVS
| |     ||   ..   .. |||.||.|.||| .|. 
pylkplfgilaknqlengnrPlvvacsdGvGrsGtflv

SID-1_RNA_chan dsRNA-gated channel SID-1 764-885 3e-06 12.9 Pfam-A 99-212 (570) alignment
Range on Protein: 764-885
Range on HMM: 99-212/570.0
TLQPSQTVSVTTTEEP-MDESTNLMIFIGIGCGIVLVSaLIVAVVCFYKRNKianddMEQGTKIEKEKIARELAAQEAQNIEaEKKKKEIKDLEakVDYE
  . |.|..||..|.  . ..|...... . . ...|  |..|...  |. |     . . ..|..|  . |  |.. |. | ......... .  .  .
nrtksitlkvtklesieykkatlaivivllsllllfvv.lviaiikekkelk.....avskeiissepsgseqramdlqeke.seedssleeed..ilka

KQKGEKIKEEAEKEIQDHRKKVE
.|. | |.|.|. ...|  .| |
eqeievirekaaltvsdlsrkde

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1046-1263 4.2e-06 20.5 In-house 103-296 (310) alignment
Range on Protein: 1046-1263
Range on HMM: 103-296/310.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQKFHNVNVctTNVQHPSADVVLRTLVITSY-----LGE---KKKTHTVKHYSYKG
| .|.  |.. | |  .| . .||   |||  || .|.|      . .  . |  ||.   | .  .  | .|       . |   . |   |.   .  
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygcirv..tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpn

WIEKNAPELPREILNIFRVAR-NSKSLVVHCSNGIGRSAAFVswelcyhfvpvnfeicdfsVAEFVYQKMIRSLdttstvNLDFLSLLTELRHSRPRAIH
| ..  |.     .    .|.      ||||| |..|  . |                     .. ..|. | |      ..|.  . |||..||   | 
wpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvv...................alklkidkldrgl......kvdaeevktellksraiciq

TPMQLafsimMVLDFVMNNFPKGEMEA
|..|      ...|.|.  | .|| | 
telqy.....liidrvriifargetev

DUF1510 Protein of unknown function (DUF1510) 790-885 4.9e-06 15.3 Pfam-A 16-114 (217) alignment
Range on Protein: 790-885
Range on HMM: 16-114/217.0
IGIGCGIVLVSALIVAVVCFY---KRNKIANDDMEQGTKIEKEKIARELAAQEAQNIEAEKKKKEikD--LEAKVDYEKQKGEKIKEEAEKEIQDHRKKV
. |  .||.|  .|||.  .    | .| ..|. |. .. ..||   |   .|...  ....|..  |   | | . .... |. ||..|.| ... |..
LniaiaiVvvlivivaaqllvgnskskkasadeeeeeksedeekteeeevkeeekeaakdedked..dsesekkdeeseeeeeeekekkeeeseedeket

E
|
e

IncA IncA protein 790-879 6.8e-06 15.6 Pfam-A 40-117 (191) alignment
Range on Protein: 790-879
Range on HMM: 40-117/191.0
IGIGCGIVLVSALIVAVV--CFYKRNKIANDDMEQGTkiekekiarelaaqEAQNIEAEKKKKEIKDLEAKVDYEKQKGEKIKEEAEKEIQD
. ... |.|...|.....  ...|...    |...                 ....|  . ......|| ... . .. .. ..| |.. .|
llgivliAlgvvLlalgllllllkapvqseedekiee..............srlqeelsesesqlseleeeleqleerlaeleseledleed

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 991-1088 9e-06 19.2 In-house 88-187 (349) alignment
Range on Protein: 991-1088
Range on HMM: 88-187/349.0
FKDQYINANYLELPNGNRMIltqapmsrtehfkpekdkkrknlyslsdeeEEIS---YLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFP---
  |.|||||||.|.. .                                   |.    |  ||| ||. |.  | ..|  | | .|...|||  |.    
klddyinanylkltrisvek..............................kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels

--------------------------LEKD
                           .||
ysnitvklqnsslyianvqGnslrvstvkd