Gene K09F6.3 in Caenorhabditis elegans

Synonym: CELE_K09F6.3, K09F6.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily hpo-7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP120_AA protein Get Run
CeleP120_AA_916-1253 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_hpo-7_pd Subfamily hpo-7 913-1288 3.3e-149 490.0 In-house 2-263 (263) alignment 
Range on Protein: 913-1288
Range on HMM: 2-263/263.0
LLNdfmkeegDKGATNNGKLPlkamyqfcksilrianlapnnaivesekyseqdrysdvlcgmdnRILIDEDVCrrcyfkdqyinanylelpngnrmilt
|||       ||||...||||                                            |||||||||                          
lln.......dkgalkfgklP............................................rilidedvc..........................

qapmsrTEHFKPEKDKKRKNLYSLsdeeeeisyLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpsaDVVL
      ||||||||||||||||||         ||||.||||||||||.||||.||||||||||||||||||||||.|||..|||||||.||.   ||.|
......tehfkPekdkkrknlysl.........lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvll

RTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSKSLVVHCSNGIGRSAAfvswelcyhfvpvnfeicdFSVAEFVYQKMIRSLDT
.||...|.||||||||||||||||||||||.|||.||||||..|||||||||||||.|||||||                   |||||.|||||||||||
ktlellstlgeKkkthtvkhysykgWiekndpelareilnilkvarnskslvvhcstGiGrsaa...................fsvaElvyqkmirsldt

TSTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNFPKGEMEAKYQEIRKSYLHARQMMHKDLEFDGS
||||.||.||||.|||.||.|||||||||||||.||||||.|||.|||.|||||||||||||||||||||||||||
tstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakgeleakyqeirksylharqmmhkdlefdgs
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 923-1289 9.6e-144 472.0 In-house 2-255 (255) alignment 
Range on Protein: 923-1289
Range on HMM: 2-255/255.0
DKGATNNGKLPlkamyqfcksilrianlapnnaivesekyseqdrysdvlcgmdnRILIDEDVCrrcyfkdqyinanylelpngnrmiltqapmsrTEHF
||||....|||                                            |||||||||                                |||.
dkGalkfkklP............................................rilidedvc................................tehv

KPEKDKKRKNLYSLsdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNvqhPSADVVLRTLVITSYLG
||||||||||||||            ||||||||||||.||||.|||||.||||||||||||||||.|.|...|||.||.   .|||||||||.|||.||
kPekdkkrknlysl............tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlg

EKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSKSLVVHCSNGIGRSAAFVswelcyhfvpvnfeicdfsVAEFVYQKMIRSLDTTSTVNLDFLS
||||||||||||||||||||||||.||||||..|.|.|||.|||||.|||||||||                   .||.||||||||||||.||.||.||
ekkkthtvkhysykGWieknaPelareilnilkvvrdsksvvvhCstGiGrsaafv...................laelvyqkmirsldttetveldyls

LLTELRHSRPRAIHTPMQLAFSIMMVLDFVmnnFPKGEMEAKYQEIRKSYLHARQMMHKDLEFDGSD
||.|||..|.||||||.||||||.||||.|   |||||.||||||||||||||||||||||||||||
lleelrskrkraihtPlqlafsilmvldlv...fpkgeleakyqeirksylharqmmhkdlefdgsd
DSPc_SM00195 945-1252 3.6e-63 208.7 In-house 7-262 (263) alignment 
Range on Protein: 945-1252
Range on HMM: 7-262/263.0
LRIANLAPNNAIVESEKYS--EQDRYSDVLCGMDNRILIDEDVCRrcyFKDQYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeee
 .. . .... . |.|| .  ...||...|. ...|. .... ..    ...||||||.... . ...|.||.|.                         
ekleestspketteaekkknksknRyknilpydhtrVklkkeekk...egsdYINAnyikgankkkkyIatQgPl.........................

eisylVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGekKKTHTVKHYSYKGWIEK
      .||..|.............||....|.| |||..|.| |..||..|....|....|.. .....|||| .|      ..|..|..| ||.| ..
.....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh

NAPELPREILNIFRVARNSKS-----LVVHCSNGIGRSAAFVSWELCYHFVPVNFEicdfsvaefvyqkmirsldttstvnLDFLSLLTELRHSRPRAIH
..|. ....|...|....|||     .|||||.|.||...||....... .  ...                         .|. ....|||..||....
gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.........................vdifeivkelRkqRpgmvq

TPMQLAFSIMMVLDFV
| .|..| ....|...
tleqYlfiyeaileyi
PTPc_SM00194 945-1252 3.6e-63 208.7 In-house 7-262 (263) alignment 
Range on Protein: 945-1252
Range on HMM: 7-262/263.0
LRIANLAPNNAIVESEKYS--EQDRYSDVLCGMDNRILIDEDVCRrcyFKDQYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeee
 .. . .... . |.|| .  ...||...|. ...|. .... ..    ...||||||.... . ...|.||.|.                         
ekleestspketteaekkknksknRyknilpydhtrVklkkeekk...egsdYINAnyikgankkkkyIatQgPl.........................

eisylVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGekKKTHTVKHYSYKGWIEK
      .||..|.............||....|.| |||..|.| |..||..|....|....|.. .....|||| .|      ..|..|..| ||.| ..
.....pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh

NAPELPREILNIFRVARNSKS-----LVVHCSNGIGRSAAFVSWELCYHFVPVNFEicdfsvaefvyqkmirsldttstvnLDFLSLLTELRHSRPRAIH
..|. ....|...|....|||     .|||||.|.||...||....... .  ...                         .|. ....|||..||....
gvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.........................vdifeivkelRkqRpgmvq

TPMQLAFSIMMVLDFV
| .|..| ....|...
tleqYlfiyeaileyi
0036941 (Phosphotyrosine protein) phosphatases II 931-1260 6.6e-53 175.3 In-house 9-285 (297) alignment 
Range on Protein: 931-1260
Range on HMM: 9-285/297.0
KLPLKAMYQFCKSILRIANlAPNNAIVESEKYSEQDRYSDVLCGMDNRILIdEDvcrrcyFKDQYINANYLELPN-GNRMILTQAPMSrtehfkpekdkk
.| |  ... ....|.. .  ..  . ..... | .||.|.|.  ..|. . .|       .. ||||.|..... ....|.||.|..            
llflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl.dd......egsdYinAsyvdgydlkrkfIatqgPlp............

rknlyslsdeeeeisylvQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQH-PSADVVLRTLVITSYlgEKKKTH
                  .||..|.. . . ...|. ||... | | ||| .|.|||... ...... |....|.. ...|..|||| .| .  ......
..................ntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesr

TVKHYSYKGWIEKNAPELPREILNIFRVARN-------SKSLVVHCSNGIGRSAAFVSWELCYHFVP---VNFEICdfsvaefvyqkmirsldttstvnl
||.|. |.|| . ..|| |...|.... .|.       ..  .||||.|.|||..|.  .|... .     . ...                        
tvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd........................

dFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNFPKGE
 .|... .||. || |. |..|. | ....|...... .| .
.ileavkklReqRpgavqtleqyrflyeallellkkkltkep
0040438 (Phosphotyrosine protein) phosphatases II 953-1266 9.7e-51 168.3 In-house 34-290 (317) alignment 
Range on Protein: 953-1266
Range on HMM: 34-290/317.0
NNAIVESEKYSEQDRYSDVLCGMDNRILIDEDVCrrcYFKDQYINANYLELPN-GNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVD
.  . | ..  . .||.|.|.  ..|. .  .     .. . ||||.| . || ....|.||.|.                               .||.
tysvaelpenkdknrypdilpydhsRVkLsplgg...dldsdYInAsyvdgpnlkrkfIatqgPl..............................pntve

KFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELPREIL
.|.. . . |..|. ||... | |.|||  |.||  ......... | ......  |...|||| .. .  ......||.|. |.|| . ..|. |...|
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdlll

NIFRVARN-----SKSLVVHCSNGIGRSAAFVSWELCYHFVPvnfeI----CdfsvaefvyqkmirsldttstvnldFLSLLTELRHSRPRAIHTPMQLA
.... .|.     .. ..||||.|.||...|.  .|... .          .                         . . . |||. || |. ||.|. 
dfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqle....keggvd.........................veeavkelreqRpgavqtpeqyr

FSIMMVLDFVMNNFPKGEMEAKYQ
| ....|...... .. ..  .. 
flydalleylkrkltlepaselkl
0050432 (Phosphotyrosine protein) phosphatases II 912-1256 1.3e-50 167.9 In-house 6-303 (308) alignment 
Range on Protein: 912-1256
Range on HMM: 6-303/308.0
KLLNDFMKEEGDKGATNNGKLPLKAMYQFCKSILRIANLA------------PNNAIVESEKYSEQDRYSDVLCGMDNRILIDEDvcrrcyfkDQYINAN
. | ...   ...  ... ||... . ..... | . .|             ..  . . ..  .  ||.|.|.   .|. .||.        . ||||.
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldeg........sdYInAs

YLELP---NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKD-GKQKFHN
|  ..   . ...|.||.|.                               .||..|.. . . ...|. ||... | |.|||  |.||| . | .....
yvdgyssklprkfIatqgPl..............................pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygk

VNVCTTNVQHpSADVVLRTLVITSYLGEkkKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNS---KSLVVHCSNGIGRSAAFVSWELCYHFVPVnfe
. | ......  .|...||| .| . ..  ...||.|. |..| . ..|. |...|.... .|.|   .  |||||.|.||...|.  .|... .     
ftvtllseev.lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlek...

icdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNF
                      . ..|.....  ||. || ...||.|. | ....|..... .
......................eggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 923-1256 6.6e-48 159.0 In-house 17-293 (297) alignment 
Range on Protein: 923-1256
Range on HMM: 17-293/297.0
DKGATNNGKLPLKAMYQFCKSILRIANLAPNNAIVESEKYSEQDRYSDVLCGMDNRILIDedVCRRCYFKDQYINANYLELPN--GNRMILTQAPMSRte
.  .  ....... .... .   .. .| |.  | ....  .  ||.|.|.  ..|. .   ... ... . ||||.|.. ..  ....|.||.|..   
svldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklk..pedgvdldsdYinAsyvdgydlltrkfIatqgPlpe..

hfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVeKCSSYFPLEKDgkqKFHNVNVCTTNVQHpSADVVLRTLVITSy
                            ||..|.. . . |..|. ||....| |. || .|.| | .   ..... | ...|.|  .....||| .|  
............................tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn.

lgeKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVAR-------NSKSLVVHCSNGIGRSAAFVSWELCYHFVPvnfeicdfsvaefvyqkmirsldtt
   .....||.|. | || . ..|.... .|.... .|       ...  .||||.|.||...|.   |... .                          
...ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqle.........................

STVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNNF
.. ..|.|. . |||  || |. || |. | ....|...... 
keggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0051299 (Phosphotyrosine protein) phosphatases II 934-1252 1.1e-47 158.3 In-house 25-286 (288) alignment 
Range on Protein: 934-1252
Range on HMM: 25-286/288.0
LKAMYQFCKSILRIanlaPNNAIVESEKYSEQDRYSDVLCGMDNRILIDedvCRRCYFKDQYINANYLEL-PNGNRMILTQAPMSrtehfkpekdkkrkn
|.. .. . |.|      ..  .   ... |  ||||.|.  ..|. .        .  . ||||.|... ......|.||.|..               
lleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLs...vldgvegsdYinAsyidgynlkrkfIatqgPlp...............

lyslsdeeeeisylvQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSY--LGEKKKTHTV
               .||..|.. . . ...|. ||... | |.|||  |.||  .|....... |.......  .|...||| .| .  |. .....||
...............ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtv

KHYSYKGWIEKNAPELPREILNIFRVARNS-----KSLVVHCSNGIGRSAAFVSWELCYHFVPvnfeicdfsvaefvyqkmirsldttSTVNLDFLSLLT
.|. |..| . ..|. |...|.. | .|..     .  |||||.|.||...|.  .|... .                           .  .|.|... 
thfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqle.........................keggvdvleavk

ELRHSRPRAIHTPMQLAFSIMMVLDFV
 ||. || .. ||.|. | ....|...
rlreqRpgmvqtpeqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 947-1254 1.4e-46 155.0 In-house 36-306 (307) alignment 
Range on Protein: 947-1254
Range on HMM: 36-306/307.0
IANL----APNNAIVESEKYSEQDRYSDVLCGMDNRILIDedVCRRCYFKDQYINANYLELP---------NGNRMILTQAPMSRtehfkpekdkkrknl
. ..      .  | ....  .  ||.|.|.  ..|. .   ..   .  . ||||.|  .|         .....|.||.|..                
llsvtvfllgeysiallpenkdknrykdilpydhtRVkls..sldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...............

yslsdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlGEKKKTHTVKHY
               ||..|.. . . |..|. ||... | | |||  |.|.| .... ..|. | .....|  .....||| .| . .......||.|.
...............tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdl.dgtgesrtvthf

SYKGWIEKNAPELPREILNIFRVAR-------NSKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSvaefvyqkmirsldttstvnldFLSLLTE
 |.|| . ..|. . |.|.... .|       ...  .|||| |.||...|.   |... .  . ...|..                      .|. . .
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvd......................lleavkl

LRHSRPRAIHTPMQLAFSIMMVLDFVMN
||  || |. .| |. | ....|.....
lreqRpgavqnpeqyrflyeallelllk
0047943 (Phosphotyrosine protein) phosphatases II 952-1252 1.7e-46 154.2 In-house 28-272 (273) alignment 
Range on Protein: 952-1252
Range on HMM: 28-272/273.0
PNNAIVESEKYSEQDRYSDVLCGMDNRILIdedvcrrCYFKDQYINANYLELPN-GNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTV
 .  . . ... . .||.|.|.  ..|. .          .. ||||.|....| ....|.||.|.                               .||
ltysvallpenkdknrykdilpydhsrvkl.......gdggsdyinAsyvdgynlkrkfiatqgPl..............................pntv

DKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDG-KQKFHNVNVCTTNVQHpSADVVLRTLVITSYLGEKkkTHTVKHYSYKGWIEKNAPELPRE
..|.. . . ...|. ||... | | |||  |.||| .. ....... | ......  .|...||| .|..  ..  ..||.|. |.|| . ..|. . .
edfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtge..srtvthfhytgwpdhgvppsles

ILNIFRVARN-------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLA
.|......|.       ..  |||||.|.||...|.  .|... .                           . ..|.|...  ||  || .. || |. 
llefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlek.........................eggvdvleavkllrsqRpgmvqtpeqyr

FSIMMVLDFV
| ....|...
flyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 953-1256 1.9e-45 150.8 In-house 19-278 (284) alignment 
Range on Protein: 953-1256
Range on HMM: 19-278/284.0
NNAIVESEKYSEQDRYSDVLCGMDNRILIDedVCRRCYFKDQYINANYLELP------NGNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisyl
.  .   ... . .||.|.|.  ..|. ..  ..   .  . ||||.|.. .      . ...|.||.|..                             
slsvallpenlsknRykdilpydhsRVklk..sldgdledsdYinAsyvdgydldltyikkkfIatqgPlp.............................

vQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlGEKKKTHTVKHYSYKGWIEKNAPEL
 .||..|.. . . ...|. ||... | |.|||. |.||| ......... | ......   |...||| .| . | .....||.|. |..| . ..|. 
.ntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnl.gytgesrtvthfhytswpdhgvpps

PREILNIFRVARN-------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVNfeicdfsvaefvyqkmirsldtTSTVNLDFLSLLTELRHSRPRAIHTPM
|. .|...| .|.       ..  |||||.|.||...|.  .|... .  .                        ....|.|...  ||  || ...|..
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqleke......................glllgvdvleavkrlreqRpgmvqtle

QLAFSIMMVLDFVMNNF
|. | ....|..... .
qyrfvyealleylklkl
0043336 (Phosphotyrosine protein) phosphatases II 938-1251 1.8e-43 144.4 In-house 23-276 (278) alignment 
Range on Protein: 938-1251
Range on HMM: 23-276/278.0
YQFCKSILRIANlaPNNAIVESEKYSEQDRYSDVLCGMDNRILIDEDvcrRCYFKDQYINANYLELPN-GNRMILTQAPMSRtehfkpekdkkrknlysl
..  ...|..    ..  | ....  .  ||.|.|.   .|. .. .      . . ||||.|....| ....|.||.|..                   
llefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsll...ggdldsdYinAsyvdgynvprkfiatqgPlpe..................

sdeeeeisylvqTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGEKKKTHTVKHYSYK
            ||..|.. . . |.... ||... | |..||  |.|   .| ...... | .....|  .|...||| .|     .....|| || |.
............tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtn..lgdgesrtvthyhyl

GWIEKNAPELPREILNIFRVARN-----SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSR
|| . ..|| .  .|.. ...|.     .. ..||||.|.||...|.  .|... .                           . ..|... . |||. |
gwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlek.........................eggvdleeavkelreqR

PRAIHTPMQLAFSIMMVLDF
| |. ||.|. | ....|..
pgavqtpsqyrflyealley
Y_phosphatase Protein-tyrosine phosphatase 964-1249 3.2e-43 143.2 Pfam-A 3-234 (235) alignment 
Range on Protein: 964-1249
Range on HMM: 3-234/235.0
EQDRYSDVLCGMDNRILIdedvcRRCYFK-DqYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVDKFYQTIVQTG
.. ||.|.|.  ..|. .     .    . | ||||||...  . ...|.||.|.                               .|...|.. ..|  
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgykekkkfIatQgPl..............................kstiedFWrmvwqek

TEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTT-NVQHPSADVVLRTLVITSYLGEKkKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNS
..|..||.. .|.| |||. |.| |...........| .. ...  .....||.| ...  .|. ....||.. |..| ....|| |...|.. |  ..|
vkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveks

K-----SLVVHCSNGIGRSAAFVSWELCYHFVPV--NFEICDfsvaefvyqkmirsldttstvnldflsLLTELRHSRPRAIHTPMQLAFSIMMVL
|     ..|||||.|.||.. ||. ... . .    ......                           .. |||..|| .. .  |..| ....|
keaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlq...........................ivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 964-1249 3.2e-43 143.2 In-house 3-234 (235) alignment 
Range on Protein: 964-1249
Range on HMM: 3-234/235.0
EQDRYSDVLCGMDNRILIdedvcRRCYFK-DqYINANYLELP-NGNRMILTQAPMsrtehfkpekdkkrknlyslsdeeeeisylVQTVDKFYQTIVQTG
.. ||.|.|.  ..|. .     .    . | ||||||...  . ...|.||.|.                               .|...|.. ..|  
kknRykdilpydktrvkl.....kgsegpsd.YInAnyvkgykekkkfIatQgPl..............................kstiedFWrmvwqek

TEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTT-NVQHPSADVVLRTLVITSYLGEKkKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNS
..|..||.. .|.| |||. |.| |...........| .. ...  .....||.| ...  .|. ....||.. |..| ....|| |...|.. |  ..|
vkvivmltsleekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkveks

K-----SLVVHCSNGIGRSAAFVSWELCYHFVPV--NFEICDfsvaefvyqkmirsldttstvnldflsLLTELRHSRPRAIHTPMQLAFSIMMVL
|     ..|||||.|.||.. ||. ... . .    ......                           .. |||..|| .. .  |..| ....|
keaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlq...........................ivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 964-1254 4.9e-43 142.9 In-house 35-274 (278) alignment 
Range on Protein: 964-1254
Range on HMM: 35-274/278.0
EQDRYSDVLCGMDNRILidedvcrrcyfkDqYINANYLELPnGNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvQTVDKFYQTIVQTGTE
. .||.|.|.   .|.             | ||||.|.. . ....|.||.|.                               .||..|.... . |..
dknRykdilpydhsrVk............d.YINAsyidgy.pkkfIatqgPlp..............................stvadfwrmlwelgit

VVAMLCDFNEEGVEKCSSYFPlEkDGKQKFHNVNVCTTNVQHPsADVVLRTLVITS--YLGEKKKTHTVKHYSYKGWIEKNAPELP--REILNIFRVAR-
|. ||... | |.|||  |.| | .| . .... |.......   |..|||| .|   .  |  ....|.|. |..| . ..|.||  . .|....  | 
vivmltelvelgrekcaqywp.e.ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefire

-----------------NSKSLVVHCSNGIGRSAAFVSWELCYHfvpvnfeicdfsvaefvyqkmirsldttstV---NLDFLSLLTELRHSRPR-AIHT
                 ...  .|||| |.||....|   |...                                  ..|.|. ..|||  ||  |. .
alkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle..............................lleggvdlleavkelrsqRpglavqn

PMQLAFSIMMVLDFVMN
..|. | ....|.....
leqyrflyefllelllr
0040439 (Phosphotyrosine protein) phosphatases II 963-1254 2.5e-41 137.3 In-house 12-248 (249) alignment 
Range on Protein: 963-1254
Range on HMM: 12-248/249.0
SEQDRYSDVLCGMDNRILIdeDVCRRcYFKDQYINANYLELPN-GNRMILTQAPMSRtehfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTG
 . .||.|.|.   .|. .   ...  .| . ||||.|..... ..|.|.||.|..                               ||..|.. . . |
kdknrypdilpydhsrvkl..silpg.lflsdyinAsyidgyyikrrfiatqgPlpe..............................tvedfwrmlwelg

TEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN--
 .|. ||... | | |||  |.||  .| ...... | ...|.. ..|...||| .| .  ......||.|. | .| . ..|. . ..|.... .|.  
itvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkal

-----SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMN
     .. ..||||.|.||...|.   |... .                           . ..|... . .||. || |. .| |. | ....|.....
eelpkggpvlVHCsaGvgRtGtfiaaylmleqlek.........................elgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
0042113 (Phosphotyrosine protein) phosphatases II 964-1252 1.1e-38 128.4 In-house 11-243 (245) alignment 
Range on Protein: 964-1252
Range on HMM: 11-243/245.0
EQDRYSDVLCGMDNRILIDEDVCrrcYFKDQYINANYLELPN-GNRMILTQAPMSRtehfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTGT
.  ||||.|.  ..|. . .|      . . ||||.|  ...  ...|.||.|..                               ||..|.. . . | 
dknrysdilpydhtrvklspdgg...dldsdyinasyvdgyritpkfiatqgPlpe..............................tvedfwrmlwelgi

EVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN---
... ||... | | .||  |.||  ......... |......|  .|...||| .|     ......| || | .| . ..|.|.. .|.... .|.   
ttivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldflefvrkala

---SKSLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFV
   .. ..|||| |.||...|.   |... .                           . .... . . |||  || |. || |. | ....|...
edsngpvlVHCsaGvgRtGtfiaaylmleqlek.........................elgvsleeavkelrsqRpgavqtpsqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 964-1250 3.5e-37 123.7 In-house 12-240 (243) alignment 
Range on Protein: 964-1250
Range on HMM: 12-240/243.0
EQDRYSDVLCGMDNRILIdedvcRRcyfkDQYINANYLELPngNRMILTQAPMSRTEhfkpekdkkrknlyslsdeeeeisylvqtvDK----FYQTIVQ
.  ||||.|.  ..|. .           . |||||. . .  .|.|.||.|.. |                               .     |.. . .
sknrysdilpydhsrvkl.....eg....sdyinanliyvt..prliatqgPlpetv..............................eddlasfwrmlwe

TGTEVVAMLCDFNEEGVEKCSSYFPlekdGKQKFHNVNVCTTNVQHPsADVVLRTLVITSyLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN
 |..|. ||... | |.|||  |.|    |.. .... | .....|  .|...|||...  |.... |..| || | .| . ..|. |  .|.... .|.
lgitvivmltelvElgrekcaqywp....gevtygdftvtllseehl.ddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevre

-------------SKSLVVHCSNGIGRSAAFVSWELCYHFVpvnfeicD-FsvaefvyqkmirsldttstvnldFLSLLTELRHSRPR-AIHTPMQLAFS
             .. ..|||| |.||.....   |... .       .                         ... . .||  ||  |. || |. | 
fieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll.......gvd.......................leeavkllreqRpgkavqtpsqyrfl

IMMVLD
....| 
yealle
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 990-1188 5.1e-36 119.3 In-house 43-219 (290) alignment 
Range on Protein: 990-1188
Range on HMM: 43-219/290.0
YFKDQYINANYLELPNGNRMILTQAPMSRTehfkpekdkkrknlyslsdeeeeISYLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVE----KCSSYFPL
 |.|.|| ||..  ||| |.||||.|  ..                       ..    |. ||. .. |   . | |||.|.|.  .     |. |.| 
rfnddyiHAnrvtcpnglrliltqsPqeki.......................tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe

EKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITsYlgEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSK-SLVVHCSNGIGRSAAFVSWELCY
. ... ||....|  ..  .   ||  |.||.. .  .... .||.|. .||| . |..| .. .|.. .  ..||   .||| .|| ||||. . .| |
svgeelkfkgltvkCkskek.eddvetRelvvk.f..ddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgy

HFVP
  ..
Qkia
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 989-1179 1.3e-24 81.2 In-house 57-240 (302) alignment 
Range on Protein: 989-1179
Range on HMM: 57-240/302.0
CYFKDQYINANYLELpNGNRMILTQAPMSRTEHFkpekdkkrknlyslSDEE-EEISYLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEK
  ||...|||| |.| .. . |..| ||  ||.                ...   |    .|..|..  | |  . .|. ||.| |.. .||..|.  . 
vdfkndfinanvlkl.deikwimaqGpmdGtekk..............ekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkv

DGKQKFHNVNVCTTNVQHPS------ADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARNSK-SLVVHCSNGIGRSAAFVS
.|. || .  | | .|..         ...| |. |. .  .||. .||.   . .| .. ||. .   |.|..     | ...||||.|.||. ..|.
ggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlva
subfamily_PTPN12_pd Subfamily PTPN12 1046-1255 3.3e-24 80.3 In-house 92-280 (290) alignment 
Range on Protein: 1046-1255
Range on HMM: 92-280/290.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgekKKTHTVKHYSYKGWIEKNAPE
| .|.| |.. | .. .|.| |.|   | |  ||  |.| |.. . .| ...| ... .. . | ..||| ..      |....|. . |. | ... |.
LpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPs

LPREILNIFRVARN-----SKSLVVHCSNGIGRSaafvswelcyhfvpvnfeiCDFSVAEFVYQKMIRsldTTSTVNLDFLSLLTELRHSRPRAIHTPMQ
 . ..|.. . .|.     .. |||||| |.||                        . ..|.. . .    . . .||  .|..|||. |. .. |  |
saksllelielvrelqesedaPlvvhCsaGvGrt...................Gtiiaidyvrellka...ekipeeldvfdlvlelrkqraalvqtkeq

LAFSIMMVLDFVMNN
  .  . |...| ..
yelvykavaelvqke
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1047-1185 1.6e-23 77.8 In-house 104-241 (290) alignment 
Range on Protein: 1047-1185
Range on HMM: 104-241/290.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPEL
 .||  ... ..|... .. |||.  |.|  ||. |.| ..     | .. |  .. ... |.....|| .     .. | | .||.  | | .|  .  
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdk..dsGkehklkhlkikswpdksvals

PREILNIFRVARN-SKSLVVHCSNGIGRSAAFVSWELCYH
   .| ..|. |. |  .||||| ||||. .||. | .  
tlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglq
subfamily_PTPRD_pd Subfamily PTPRD 1047-1179 2.2e-23 77.7 In-house 101-233 (564) alignment 
Range on Protein: 1047-1179
Range on HMM: 101-233/564.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDgKQKFHNVNVCTTNvQHPSADVVLRTLVItsYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.. | . . .  .... ||   .|.| .||..|.| . . .... .. |  .. ..  ||...||. .     .......|... .  | ....|| 
aetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtlee.eeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpes

PREILNIFRVARNS-----KSLVVHCSNGIGRSAAFVS
....|.. |  |..     . .|||||.|.||. .|. 
atslLdlirkvralnepdagPivVhCSaGVGRTGtfiv
subfamily_PTPN6_pd Subfamily PTPN6 960-1202 2.7e-23 77.4 In-house 52-269 (306) alignment 
Range on Protein: 960-1202
Range on HMM: 52-269/306.0
EKYSEQDRYSDVLCGMDNRILIDedvcRRCYFKDQYINANYLELPNGNRmiltqapmsrtehfkpekdkkrKNLYSLSDeeeeiSYLVQTVDKFYQTIVQ
 .. |..||  .|   ..|. .     .     ..||||||..    .                       .. |  ..       | .||  |.. ..|
penkeknryknilPfDhtrvilk....epsvpgsdyinanyikkevkgs......................dksyiatq.....gclettvsdFWrmvwq

TGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQkFHNVNVCTTNVqHPSADVVLRTLVITSYlGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFR-VAR
  ..|. |.   .| | |||. |.| |.. .. . ...| ...  .  || .||.|...    .||....| .| .| | ... |. |  .|. .. | |
ensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

NS--------KSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSVAEFV
..         ..|||||.||||  .|.  ..  . .  .   .|. . ..|
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1046-1183 3.5e-23 76.8 In-house 99-237 (301) alignment 
Range on Protein: 1046-1183
Range on HMM: 99-237/301.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVV-LRTLVITSyLGEKKKTHTVKHYSYKGWIEKNAP
| .| . |.  .||   | ..||. . |. .|||..|.|..   | .    .. ..| ..   . .  ||| ..    .| .|.|| || |. | ... |
lkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleved.stgkfatrtvthyqysewtdrgvP

ELPREILNIFRVARNS-KSLVVHCSNGIGRSAAFVSWELC
.   |. ..  ....| | .|||||.||||| ||.. |  
kshaelfdlmelvkksekPivvhcsaGiGrsvafigteyl
0041856 (Phosphotyrosine protein) phosphatases II 965-1255 3.6e-22 74.3 In-house 4-174 (182) alignment 
Range on Protein: 965-1255
Range on HMM: 4-174/182.0
QDRYSDVLCGMDNRilidedvcrrcyfKDQYINANYLELPNGN-RMILTQAPMSRtehfkpekdkkrknlyslsdeeeeisylvqTVDKFYQTIVQTGTE
 .||||.|.   .|                |||||..  .  . |.|.||.|. .                              || .|.... . |  
knrysdilpydhsr.............dldyInanlylgslpatrfiatqgplls..............................tvadflrmlkelgit

VVAMLCdfneegvekCSSYFPlekdgkqkfhnvnvcttnvqhpsadvvlrtlvitsylgeKKKTHTVKHYSYKGWIEKNAPElPREILNIFRVARNS-KS
.. .|.         .  |.|                                       .. .... .| | .|   ..|. ..|.|.. . .... . 
tivnlt.........eelywp.......................................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggp

LVVHCSNGIGRSAAFVSWELCYHFvpvnfeicdfsvaefvyqkmirsldttstvNLDFLSLLTELRHSRPRAIHTPMQLAFSIMMVLDFVMNN
 .|||| |.||....|   |...                               .... . . ..|  || .. || |. |  ...|......
vlVHCsaGvgRtgtlvaaylmkkl..............................gvsleeavklvrsrRpgmvitpnqyfflqlallellllk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1046-1180 4.5e-22 73.6 In-house 98-236 (305) alignment 
Range on Protein: 1046-1180
Range on HMM: 98-236/305.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYLGeKKKTHTVKHYSYKGWIEKNAPE
| .||. |...||.. .... ||..  |.| .||  |.| .|  |..| ...|  .. ..  .| . | | |.   . .|...|| .|    | ..  |.
lkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiede.dkesrtvlqyqltdWPdhGvpq

LPREILNIFRVARN----S--KSLVVHCSNGIGRSAAFVSW
 .  .|....  ..    .  ..|.||||.|.||. .|.. 
fatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiav
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1046-1243 4.6e-22 73.4 In-house 82-259 (274) alignment 
Range on Protein: 1046-1243
Range on HMM: 82-259/274.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDG--KQKFHNVNVCTTNVQHpSADVVLRTLVITSYLGEKKkthtVKHYSYKGWIEKNA
|..||. |.. | |. ..|. || ...|.  .||. ||| ..|   .... .|.. .... .   |  .|.||. .   |..    |||| |  | ....
lpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekive.rndysvrklvlkylerers....vkhywytdWPdhks

PELPREILNIFRVA------RNSK--SLVVHCSNGIGRSAAFVSWELCYHFVPVnfeicdfsvaefvyqkmirsldttsTVNLDFLSLLTELRHSRPRAI
|. ....|.. .        .| |  . ||||| ||||  .|.. ... . .                           .  .| |.. ..||  |   .
PddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlre.........................eivvdvlkivcnlrldrGGmv

HTPMQLAF
.|  |  .
qtseqyel
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 956-1186 1.2e-21 71.9 In-house 14-223 (270) alignment 
Range on Protein: 956-1186
Range on HMM: 14-223/270.0
IVESEKYSEQDRYSDVLCGMDNRILIDEDVCrrcYFKDQYINANYLElpngnrmiltqapmsrtehfkpekdkkrknL-------YSLSdeeeeISYLVQ
. |  . .. .|| |.|     |. ..|        . .||||||..                                      |  .      . |  
lpeaargkklnRyadiLPsPatRvrleelee...dsataYinAnyvr..............................GfdgekkkYiaa.....mgPlpt

TVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGEKKKthtVKHYSYKGWIEKNAPELPR
|. .|...|... .. ..|. ...|.| .||. |.| |.. | |... .. ......  ..  ..| .   . ||...   . |. |. | .. .|. . 
tlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerr...lvHfwyntWpdhgvpreed

------EILNIFRVARNS-----K--SLVVHCSNGIGRSAAFVSWELCYHF
      ..|...|  |.|     |   |.||||.|.||.  ..  . . . 
sslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrl
subfamily_PTPRB_pd Subfamily PTPRB 1046-1180 4.5e-21 70.1 In-house 103-238 (293) alignment 
Range on Protein: 1046-1180
Range on HMM: 103-238/293.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDgKQKFHNVNVCTTNVQHpSADVVLRTLVITSylgeKKKTHTVKHYSYKGWIEKNAPE
| .|||.|.. . .. .... || .  |.| .||  |.| ...  . . ...|  .. ..   | |.|.| |.     .|....|..| .. | . . ||
lpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlvaeee.ledwvirelkiek....ekeerkvrqyhftsWpdhgvPe

LPREILNIFRVARNSK-------SLVVHCSNGIGRSAAFVSW
 .. .|...|  |...        .||||| |.||. .|.. 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1046-1182 4.7e-21 70.1 In-house 99-234 (288) alignment 
Range on Protein: 1046-1182
Range on HMM: 99-234/288.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITsylgEKKKTHTVKHYSYKGWIEKNAPE
| .||..|.. . .. |. ..|| .. |.| .||  |.| ..| .... .|.|  .....   |.|||.| .      ||.  ....| |..| ... ||
ladtvndfWelvyenktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveske.ledfvlrkllle....kkkteleitqyqylaWpdhgvPe

LPREILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWEL
  ...|.. |        ... ..||||.|.||.  |.. . 
skapllellrqvkvanqadtgpiivhCsaGvGrtgtFialda
subfamily_PTPN3_pd Subfamily PTPN3 1046-1193 2e-20 67.9 In-house 93-241 (280) alignment 
Range on Protein: 1046-1193
Range on HMM: 93-241/280.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLeKDGKQKFHNVNVCTTNVqHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
| .|. .|.| . .  .... || .  |.|  ||  |.|  .. .... . .|  ..  . .  .||| ||..    |.|. ... .  |  | ... |.
laktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.detksyvlrelvlkdk..etkeerkilqlqylaWpdhgvPd

LPREILNIFRVARNSK-----SLVVHCSNGIGRSAAFVSWELCYHFVPVNFEI
 . ..|.. .  |. .      .||||| ||||.  ..  |.. . .  . ..
dsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepv
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1046-1178 4e-20 67.3 In-house 108-241 (298) alignment 
Range on Protein: 1046-1178
Range on HMM: 108-241/298.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNvQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
|..||  |.. ...   ... || . .| .  |.. |.|  ..||... ...|   . ..  ||.. |.| ....  ...|...|.. ..  | .| .||
ltetvedFWrmvteedigtiVmltnleeldktkyhkywP..degketygeitvslls.keefadlivrklkvskk..keekerevrqlhftsWpdkgvpe

LPREILNIFRVARN----SK--SLVVHCSNGIGRSAAFV
  . .|.. |  |     ..  ...|.||.|.||| .|.
natsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi
0051429 (Phosphotyrosine protein) phosphatases II 1049-1288 6.1e-20 67.5 In-house 34-262 (272) alignment 
Range on Protein: 1049-1288
Range on HMM: 34-262/272.0
TVDKFYQTiVQTGTEVVAMLCDFNEEGVEKCSSYFP--------LEKDGKQKFHNVNVCTTNVQH-PSADVVLRTLVITSYLGEKKKtHTVKHYSYKGWI
|.. | .   . |  .. .|.. .| | .||. | |        .. |. .     ... |...     |..||.|..| .|. ..  ..| |. | .|.
taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagea.revmhlhytdwp

EKNAPELPreILNIFRVARNSKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDFSVAEFVyqkmirsldttstvnldFLSLLTELRHSRPRAIHTPM
  ..|. .  .|..... .... ..|||| |..|.. .|   |... |. .  . |.   ..                   .  . |||  || |. |..
dhgvpqea..llellellldggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly.................leeaveelraqrpgavqtee

QLAFSIMMVLDFV--MNNFPKGEMEAKYQEIRKSYLHARQMMHKdLEFDGS
|..|  . .|...  . . .   ..| ...|.. |   .. ... | .. .
qylflyeallellrsllsvraeyllaaldaideeyGsvegYLrd.lglsee
WSN Domain of unknown function 1-58 8.1e-20 60.5 Pfam-A 10-67 (69) alignment 
Range on Protein: 1-58
Range on HMM: 10-67/69.0
MQKISRIVNSIYLTAELTAGTANTYDLIAEFFNFGPDSYNKLQSIDMKELKSGLEEIV
...|.|..|.||| |.|. |. . .|.|||..|.|..| ..|..||...||..|... 
lsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls
subfamily_Ptp69D_pd Subfamily Ptp69D 1048-1182 1.1e-19 65.7 In-house 102-241 (307) alignment 
Range on Protein: 1048-1182
Range on HMM: 102-241/307.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkdGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYL---GEKKKTHTVKHYSYKGWIEKNAP
.|.. |.. | .   ... || . .|   .||. |.| |   .... ...| . . ..   | . |.| ..      || .... |  |.|.|| . ..|
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvP

ELPREILNIFRVA----RNS-KSLVVHCSNGIGRSAAFVSWEL
| .| .|.. . .    ...   .|||||.| |||. ||. ..
evargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1046-1179 4.9e-19 63.5 In-house 61-194 (250) alignment 
Range on Protein: 1046-1179
Range on HMM: 61-194/250.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEkCSSYFPLEKdgKQKFHNVNVCTTNVQhPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
|..|. .|.. ...  .... || ...|.. . .. |.| ||   .|. .| |   . .   ||.. |.|.....  .|..  .|.....  | .|  ||
lqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek..aekyGdvtvsllske.efadytkrklklska..kkaderivrqlhfvvWPdkgvPe

LPREILNIFRVAR-NSK-----SLVVHCSNGIGRSAAFVS
  . .|.. .  . . .      ..|.||.|.||| ||. 
vatavLellkkvqasqqqagnaPvivqCsaGvgrsGafia
subfamily_PTPN1_pd Subfamily PTPN1 1046-1253 5.5e-19 63.0 In-house 80-272 (290) alignment 
Range on Protein: 1046-1253
Range on HMM: 80-272/290.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKD-GKQKFHNVNVCTTNVQHPSA-DVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNA
|..||| |.| . .  .  | ||  . |..  || .|.| ...  . .......  . ... .    ..|.| ..    . ..|... |. |  | .   
lpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenl..ktqetreilhfhyttwpdfgv

PELPREILNIFRVARNSKSL-------VVHCSNGIGRSAAFVSWELCYhfvpvnfeicdfsvAEfvyqkmIRSLDTTSTVNLDflSLLTELRHSRPRAIH
|| |   |. .   |.| ||       |.||| ||||| .|.  . |               ..      |   | .|.|..     | |||. |   | 
pespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtcl..............vl......iekkddlssvdik..kvllelrkyrlGliq

TPMQLAFSIMMVLDFVM
|. || || . .|. . 
tadqlrfsylaileGak
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1046-1179 1.5e-18 61.7 In-house 100-235 (290) alignment 
Range on Protein: 1046-1179
Range on HMM: 100-235/290.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQkFHNVNVCTTNVQHPSaDVVLRTLVITSYLGEkKKTHTVKHYSYKGWIEKNAPE
. .|. .|.. |.|  . .. ||.. .||| .||  |.| . | |. . ....  .| .. . . . |.| ...   . .....|..|  . | ..   .
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln.eyierklevknknsa.gakqsvtqyqitnwdstgkvt

LPREILNI-FRVAR-----NSKSLVVHCSNGIGRSAAFVS
 |  || .  .. .       .|.|||||...|||| |..
npqtillvieemyktqrkrgntsivvHCSdtvgrsavfca
subfamily_PTPN13_pd Subfamily PTPN13 1046-1203 7.8e-18 59.7 In-house 86-226 (273) alignment 
Range on Protein: 1046-1203
Range on HMM: 86-226/273.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHN-VNVCTTNVQHPSAdVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAP
| .||. |.| . .  .||.||.    |.|  ||  |.| .|. | | .| ..|   .||. ..  |.|.| ..    | .... | |  .  | . . |
lPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldg.fvvralavkds..esgesrevahlnfvkwPdhgvP

ELPREILNIFRVA----RNSKSLVVHCSNGIGRSAAFVSWELCyhfvpvnfeicdfsvaefvY
  . |.|.. .      ...  .||||| ||||| .... .                      
ssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvv...................l
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1046-1179 8.3e-18 59.5 In-house 98-232 (318) alignment 
Range on Protein: 1046-1179
Range on HMM: 98-232/318.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGEKKKTHTVKHYSYKGWIEKNAPE
| .|.. |.. . . .. |. || . .|.| .|.  |.|  ..| ... .. |  ..  . ..| |||.. .|    |.... .|. | |  | ... ||
lpetieDfWrmvWeqnsavivmltqeeergkakvhryWP..skgsrsygklvvelkeeve.lsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpe

LPREILNIFRVARNS------KSLVVHCSNGIGRSAAFVS
 . ..|.. | ...       . .||||| |.||   |. 
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfia
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1046-1177 8.5e-18 59.4 In-house 91-221 (288) alignment 
Range on Protein: 1046-1177
Range on HMM: 91-221/288.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVnvCT-TNVQHPSADVV-LRTLVITSYLGEKKKthTVKHYSYKGWIEKNA
|  |...... ..... | . |||.. | | ||   |||...  | ..  .  || . ...   | .   .|.  |  ||.|.   ||.  .. | ..  
lngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl..ctvvkkkradidklvkvsllriskegeekv..ivkilhlleWdddgv

PELPREILNIFRVARN-SKSLVVHCSNGIGRSAAF
||     |..  | ..  | .|||.|.|.||....
PenylsplrllevlkslqkPivvhssaGvGrtgtl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1049-1196 9.1e-18 58.9 In-house 93-236 (281) alignment 
Range on Protein: 1049-1196
Range on HMM: 93-236/281.0
TVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSAdvVLRTLVITSYLGEkkkTHTVKHYSYKGWIEKNAPELPR
|   |.. | |  |  . |||.| |   |||. ||| .     .| .. |   .     .  .. | .  || ||   |. . |. .| | . . ||   
tradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnks..lvttrlnlsyege...trlithwlwkewpdwqvpesse

EILNIFRVAR-NSKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICDF
 .|.|.|  |  |   |.||| |.||| .... |.. . .   | . | 
vmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshftlpdi
0036282 (Phosphotyrosine protein) phosphatases II 994-1243 1.1e-17 59.7 In-house 3-161 (174) alignment 
Range on Protein: 994-1243
Range on HMM: 3-161/174.0
QYINANYLELPN-GNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvqtvdkFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekdgkqk
 ||||..| |    .| |..|.|..                                   |.. . . | ..| ||.. .| | .||  |.|        
dyinaspldlsyitprliagqgpla...................................fwemlkelgittvvmlleekelglykcinywpe.......

fhnvnvcttnvqhpsadvvlrtlvitsylGEKKKTHTVKHYSYKGWIEKNAPELPReILNIFRVARNS------KSLVVHCSNGIGRSAAFVSWELCYHF
                               .  .... .| | .|   ..|.|.  .|.... ...       . ..|||| |.||....|   |... 
.............................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrg

VP---VNFeicdfsvaefvyqkmirsldttstvnldfLSLLTELRHSRPRAIHTPMQLAF
     |.                              |.|. |||  ||... || |. |
lleslvda.............................ldlvrelRlqrpgmvqtpsQyrf
subfamily_PTPN23_pd Subfamily PTPN23 1048-1252 2e-17 58.0 In-house 94-280 (288) alignment 
Range on Protein: 1048-1252
Range on HMM: 94-280/288.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPELP
.|.  |.. ...  ..|. || . .| | .|...|.| .|.  .|| ...|   .|.. .  .| |.| ..    .......|.|  .. | |  .|. |
stlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.tethvervlkletl..dadavksvshlqltsWpelGvPasP

REILNIFRVARN---------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFEICdfsvaefvyqkmirsldttstvnlDFLSLLTELRHSRPRAIHTP
 ..|... ....          . |||||| |.||. .|       . . ..  .                         | . ..  ||. |   ... 
etllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll........................diiqvvsrlreqRrfmvqek

MQLAFSIMMVLDFV
 || ||  .||  .
eqlkfsyeavleaa
0046846 (Phosphotyrosine protein) phosphatases II 1046-1249 2.2e-17 58.8 In-house 32-170 (176) alignment 
Range on Protein: 1046-1249
Range on HMM: 32-170/176.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQkfhnvnvcttnvqhpsadvvlrtlvitsylgekkkthtvkHYSYKGWIEKNAPE
|..|. .| . . . | ..| .|..  | |  ||  |.|.... .                                         .| . .| . ..|.
lprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi........................................qylhlpwpDhgvpd

LpREILNIFRVARNS----KSLVVHCSNGIGRSAAFVSWELCyhfvpvnfeicdfsvaefvyqkmirsldttS-TVNLDFLSLLTELRHSRP-RAIHTPM
| . .|....  |.     .  .|||| ||||....|   |.                                  .|. .  | ..|  || .|. || 
l.elllellefirealkeggpvlVHCsaGigRtgtlvaayll..............................elekglsveealalvreqRplgavqtpe

QLAFSIMMVL
|. |  ...|
Qyrflyefel
subfamily_PTPRN_pd Subfamily PTPRN 1046-1182 2.5e-17 57.6 In-house 109-246 (297) alignment 
Range on Protein: 1046-1182
Range on HMM: 109-246/297.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkdGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
| .|| .|.|.. . |. |. .|.  .||||..|. |.| |  |.. .|  .|        . | ..|.. .     ....| ||  . .  | |...| 
lastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvrsfylknl..qtsetrtvtqfhflswpeegvPa

LPREILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWEL
 .. .|.  |         | ..|||||.| ||. ...  .|
saksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidl
subfamily_PTPRK_pd Subfamily PTPRK 1047-1182 3.2e-17 57.3 In-house 96-232 (314) alignment 
Range on Protein: 1047-1182
Range on HMM: 96-232/314.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQkFHNVNVCTTNVQhPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .||  |.. . . ..  . || .. |.|  ||. |.|  .|... . ...|   ... . |..| |.. ..     ......|... . || . . |  
qetvkdfWrlvydencasivmltelvevgrvkClkyWP..edtev.ygdikvelvete.llaelvvrifrveklargqeeirevrqfqflgWpdhdvPvs

PREILNIFRVARN-----SKSLVVHCSNGIGRSAAFVSWEL
 . .|.. |   .        .|||||.| ||. .|.  . 
atgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi
PTPc_DSPc_SM00012 1129-1249 4.3e-17 57.6 In-house 1-104 (105) alignment 
Range on Protein: 1129-1249
Range on HMM: 1-104/105.0
TVKHYSYKGWIEKNAPELPREILNIFRVARNSK-------SLVVHCSNGIGRSAAFVSWELCYHFVPVNFeicdfsvaefvyqkmirsldttstVNLDFL
||||| |.|| ....|| . .||...|  ...|       ..|||||.|.||.. ||  ..... .  .                          ..|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket........................kevdif

SLLTELRHSRPRAIHTPMQLAFSIMMVL
 .. |||..||... | .|  | ....|
qivkelrkqRpgmvqteeqylflyrall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1046-1183 5.4e-17 56.4 In-house 105-244 (305) alignment 
Range on Protein: 1046-1183
Range on HMM: 105-244/305.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNV----NVCTTNVQHPSADVVLRTLVItSYLGEKkkTHTVKHYSYKGWIEK
| ||.|.|.  ..|   | . |||   | |  ||. |.|. .  |.....     ||  ..  .  |.. . .| . .| |..  . .|.|  .  | ..
ldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnl.tysgdq..kmsvrhlqwtewpdr

NAPELPREILNIFRVARNSK-SLVVHCSNGIGRSAAFVSWELC
  |      |...   | ||  .||||| ||||. . |. |  
gvppckltslellsairgskvpivvhcsagigrtgtivaieyi
0043147 (Phosphotyrosine protein) phosphatases II 994-1244 5.6e-17 57.5 In-house 6-153 (172) alignment 
Range on Protein: 994-1244
Range on HMM: 6-153/172.0
QYINANYLELPNG-NRMILTQAPmsrtehfkpekdkkrknlyslsdeeeeisyLVQTVDKFYQTIVQTGTEVVAMLCDFneegvekcssyfplekdgkqk
 ||||.||.|.   .| | ||.|                              |  |...|.. . . |  .. .|...                     
dyinasyldlyyipdrfiatqgp..............................lrntladfwrmlkelgithivnltel.....................

fhnvnvcttnvqhpsadvvlrtlvitsYLGEKKKTHTVKHYSYKGWIEKNAPeLPREILNIFRVARN------SKSLVVHCSNGIGRSAAFVSWELCYhf
                           ..  .. .... .| | .|   ..| |.. .|....  ..      ..  .|||| |.||....|   |..  
...........................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml..

vpvnfeiCDFsvaefvyqkmirsldttstvnlDFLSLLTELRHSRPRAIHTPMQLAFS
       ...                      ...  . ..|. || |. .| |. | 
.......lgl......................sleeavalvrekRpgavqnpsqyrfl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 952-1179 9.6e-17 55.8 In-house 23-218 (283) alignment 
Range on Protein: 952-1179
Range on HMM: 23-218/283.0
PNNAIVESEKYSEQDRYSDVLCGMDNRILIDEDVCrrcyfkdQYINANYLELpngnrmiltqapmsrtehfkpEKDKKRKNLYSLSDeeeeiSYLVQTVD
 .  |  ...  ...|. ...    .|. .. .         .|||| .. .                     .|..|... |  .      | | .|| 
ldadiasadenkrknrnqeivpadqwrvelksesr.......dyinavfipv.....................sksykqdkkyiiaq.....sPldrtvv

KFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNvQHPSADVVLRTLVITsYLGEKKKTHTVKHYSYKGWIEKNAPELPREIL
 |.. . .     . ||  . |.  .||| |.|  |.| ... .  |   . .  |   . . |..  . .  |.|  . || . .|.| .       ..
dfWkmvfdekitaivmltklqedlrikCsqyWP..krGsedyGeftvtlrk.ettsnsfiikelllr.vnssakstlllahyqvidWleygeqaiinslv

--N-IFRVARNSK--SLVVHCSNGIGRSAAFVS
  | .    ..||   .|||||.||||.|.|..
kfnkvislqteskkgPivvhCstgiGrtavfia
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1048-1181 9.7e-17 55.6 In-house 99-240 (305) alignment 
Range on Protein: 1048-1181
Range on HMM: 99-240/305.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHN----VNV-----CTTNVQHPSADVVLRTLVITSYLGEkkKTHTVKHYSYKGW
.|   |.   .|   | . |||.. | | .||. ||. ... . .|..    . |      | . ..... .| .| ..    ||  |.. |.|| .  |
ktcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpge..karkvthyhwidw

IEKNAPELPREILNIFRVARNSKS-LVVHCSNGIGRSAAFVSWE
 ..  |     ||...  || ||  .||||| ||||. . |  |
pdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmle
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1048-1181 1.4e-16 55.4 In-house 93-230 (307) alignment 
Range on Protein: 1048-1181
Range on HMM: 93-230/307.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHN----VNVCTTNVQHPSADVVLRtLVITSYLGEKKKTHTVKHYSYKGWIEKNA
.|. .|.  ..|   | | |||.  | .  ||  |.|||.  |. | .    ..|    ... . |  |   | |  .   .|. |..|. .. | .. .
ntqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgv

PELPREILNIFRVAR-NSKSLVVHCSNGIGRSAAFVSWE
|..    .|..   | .   .||||| |.||| . |.  
pqinltainlleavrydtnpvvvhcsaGvGrsGtivais
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1048-1181 1.5e-16 55.4 In-house 95-229 (281) alignment 
Range on Protein: 1048-1181
Range on HMM: 95-229/281.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylgEKKKTHTVKHYSYKGWIEKNAPELP
.....|.| ....  ....|.    |.|  ||  |.| ... . |. .| | .|. .. .|  . |.. ..    |. .| .|..  |. | .. .|. .
aslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeee.katyierkfkler...esgetreveqlaytaWPdhGvPatt

REILNIFRVA----R--NSKSLVVHCSNGIGRSAAFVSWE
.|.|.  .      .  .  .||.||| |.||. .... .
kellefrkevlkltekktkaplvihCsaGvGrtGtyialD
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1047-1179 2.8e-16 54.5 In-house 101-235 (319) alignment 
Range on Protein: 1047-1179
Range on HMM: 101-235/319.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKdgKQKFHNVnVCTTNVQHPSADVVLRTLVItSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.. |.. . . .. .| ||.. .|..  |.. |.| |.   ... .. . | . ..  .|.. | | .   . .. .| .|||. |. | ... || 
entiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrl.ivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPek

PREILNIFRVARNSKSL------VVHCSNGIGRSAAFVS
 . .|....  |.|..       |||||.|.||  .|. 
atslldllkrirksrektqsgPivvhCsaGvGRtGtfiv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1046-1180 3.8e-16 53.9 In-house 95-231 (287) alignment 
Range on Protein: 1046-1180
Range on HMM: 95-231/287.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDgkQKFHNVNVCTTNVQhPSADVVLRTLVITSYlGEKKKTHTVKHYSYKGWIEKN-AP
...|. .|.. | .   ... |||. .|.  |.|  |.| ||     . . |.  .| .  .|... |.| ..   ........|| | .  | ..   .
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknk.nkagdkqqvkqyqitnWdstgkvt

ELPREILNIFRVARNS-----KSLVVHCSNGIGRSAAFVSW
|    .| | .  ..       |.|||||...|||| |.. 
epqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaa
subfamily_PTPRA_pd Subfamily PTPRA 1047-1181 7.6e-16 52.9 In-house 111-249 (330) alignment 
Range on Protein: 1047-1181
Range on HMM: 111-249/330.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPleKDGKQKFHNVNVCTTNVQHpSADVVLRTLVIT--SYLGEKKKTHTVKHYSYKGWIEKNAP
 .||. |.. | .  .  . || ...|   |||  |.|  ..|   . |..|.  ...  . |. .| ....  .   ..||.  |. . ...| .   |
eetvedfwrmiweqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetv.lvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvP

ELPREILNIFRVARN-----SKSLVVHCSNGIGRSAAFVSWE
  |. .|....  ..     . ..||||| |.||. .|.  .
fepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivld
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1048-1183 1.5e-15 52.1 In-house 103-240 (297) alignment 
Range on Protein: 1048-1183
Range on HMM: 103-240/297.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVeKCSSYFPleKDGKQKFHNVNVCTTNVQHPSaDVVLRTLVITSylGEKKKTHTVKHYSYKGWIEKNAPE--
.||. |.. ...  . ...|| | ||.   ||  |..  ..| ..| .| | .. |.. .   . |.|..|   |. |... || | .  | .|. ..  
atvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvttfGdvsvvllsvsere.Gfikrelevtk..gkakarrvvkqyqfveWPdkaverkd

LPREILNIFRVAR------NSKSLVVHCSNGIGRSAAFVSWELC
  . .|..    |      ..  |.|||..|.|| . ... . .
sassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv
0049260 (Phosphotyrosine protein) phosphatases II 1047-1243 1.7e-15 52.5 In-house 19-141 (152) alignment 
Range on Protein: 1047-1243
Range on HMM: 19-141/152.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFplekdgkqkfhnvnvcttnvqhpsadvvlrtlvitsylgekkkthtvkHYSYKGWIEKNAPEL
 .|...|.. . . |  .. ||... | | .||  |.                                                .| .  |   ..|.|
pntladfwrmlkelgittivmltellelgklkceqyi................................................qylhlpwpDhgvpdl

PREILNIFRV-----ARNSKSLVVHCSNGIGRSAAFVSWELCYhfvpVNfeicdfsvaefvyqkmirsldttstvnLDFLSLLTELRHSRPRAIHTPMQL
.  .| ....      ....  .|||| |.||....|   |..     .                           ....  .  .|  || |. .| ||
sqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml....lg...........................vsleeavalvrekRpgavpnpgql

AF
 |
rf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1046-1181 2.9e-15 51.0 In-house 84-224 (285) alignment 
Range on Protein: 1046-1181
Range on HMM: 84-224/285.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHP-SADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAP
| .|.  |.. | |     | ||| . | |||||. |.| .     || . ..  |...    |  .| .| ..       .   ..|     | .. ||
lpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlap

ELPREILNIFR----VARNSKSLVVHCSNGIGRSAAFVSWE
|  | ......    |  . | ..|||| |.||.|.||  .
edarpmielykwvkkvnpkekpicvhcsagvgrtatfvgid
subfamily_PTPRG_pd Subfamily PTPRG 1046-1178 3.8e-15 50.1 In-house 100-238 (563) alignment 
Range on Protein: 1046-1178
Range on HMM: 100-238/563.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLekDGKQKFHNVNVCTTNVQHPSAdVVLRTLVITSYLGEKKKT----HTVKHYSYKGWIEK
| .|.| |.. | .  .... |. ...|.| .||  |.|   |. ... ...|  .. .. .     |||||     .|||     ..|..| |  | ..
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlal.ytvrtlviknlklkkkkqcdteklvrqyhytkWPdh

NAPELPREILNIFRVARNSK-S----LVVHCSNGIGRSAAFV
..|| .   |.  . .  .. .    .|||||.|.||.  ..
gvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyi
0051082 (Phosphotyrosine protein) phosphatases II 994-1207 4e-15 51.2 In-house 4-119 (151) alignment 
Range on Protein: 994-1207
Range on HMM: 4-119/151.0
QYINANYLElpngNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvqtvdKFYQTIVQTGTEVVAMLCDFNEEGveKCSSYFPLEKdgkqkf
 |||..|..    ........|..                                   |.... . |  .. .|..  | |  .| .|.| .       
dyinfsyvt....gglyrsggpla..................................dflellkelgiktivnlrseeerg..ycpeylpelg......

hnvnvcttnvqhpsadvvlrtlvitsylgekkktHTVKHYSYKGWIEKNAPELPREILNIFRVARN--SKSLVVHCSNGIGRSAAFVSWELCYHFvpvnf
                                  ..|.|. . .| . . |... ..|........  .. ..|||| |.||....|   |...      
..................................ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.....

eicdfsvaefvyqkmI
               .
...............v
subfamily_PTPN9_pd Subfamily PTPN9 1046-1184 6.4e-15 49.9 In-house 94-247 (297) alignment 
Range on Protein: 1046-1184
Range on HMM: 94-247/297.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPE
| .||. |.. . .  . |. |   . |.|  ||. |.|||..  ..| ...| . .|.. . | . |.|.|.    ..... .| |. . .| .   |.
lkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknv..kteesrkvthfqflsWPdyGvPs

LPREILNIFRVARNSKS------------------LVVHCSNGIGRSAAFVSWELCY
   ..|.. ...|. ..                  .||||| ||||. .|.. ..| 
saaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldicl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1048-1183 8.1e-15 49.5 In-house 98-233 (315) alignment 
Range on Protein: 1048-1183
Range on HMM: 98-233/315.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQhPSADVVLRTLVITsylgEKKKTHTVKHYSYKGWIEKNAPELP
 .|| |.. ..|. .  ..|. . .|.   ||  |.| .|    .| ...| . ... . .| | | ||.     . ....||  . ...| .| ...  
asvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsle.adtdgvarklvtr....kseesrtvtqfqftewPdkGvdkqt

REILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWELC
  .|.. .  .     .  ||.|||| |.||.  ..| . .
ssllklikevkadngkkefsllvhcsaGvGrtGvvisidev
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1048-1183 1.1e-14 48.4 In-house 97-232 (515) alignment 
Range on Protein: 1048-1183
Range on HMM: 97-232/515.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGEKkkTHTVKHYSYKGWIEKNAPELP
 .|| |.. ..|  .  .||. . .|.   ||. |.|       || ...| .  ..   .. . |.| ..   |..  ..||  . ...| .| .|.  
asvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea.ctggikrkltvlk..gdd..srtvtqfhfteWPdkGvpkht

REILNIFRVARNS-----KSLVVHCSNGIGRSAAFVSWELC
. .| . .  . .      .|..||| |.||   ..| . .
ssllklikevkadhgqythpliihcsaGvGrtGvvisidsv
subfamily_PTPN14_pd Subfamily PTPN14 1047-1183 1.9e-14 48.4 In-house 103-252 (300) alignment 
Range on Protein: 1047-1183
Range on HMM: 103-252/300.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLE--KDGKQKFHNVNVCTTnVQHPSADVVLRTLVITSYLGekKKTHTVKHYSYKGWIEKNAP
 .|| .|.| . ..|.....|| . .|.| ||. .||| .  |  . .| . .| |   .. |  |. ..| .   .   |.  || |  |. | ... |
eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttk.fsedsdsvittglklkhlps..keertvwhlqytDWpdhgvP

ELPREILNIF------RVARNSKS--------LVVHCSNGIGRSAAFVSWELC
| ... |.        | . ||..        ..||||.|.||.   .  .| 
eDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1048-1181 9.3e-14 46.4 In-house 115-245 (319) alignment 
Range on Protein: 1048-1181
Range on HMM: 115-245/319.0
QTVDKFYQTIVQTGTEVVAMLCdfneegVEKCSSYFPLEKDGKQKFHNVNVctTNVQHpSADVVLRTLVItSYLGEKKKTHTVKHYSYKGWIEKNAPELP
 |.. |.. | .  .  . .|        .||| |.||. . |..  .|.|  . |.  .|. |.| . . |  |..|    .. . ..|| ..  |. |
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkv..dsvee.taeyvvrdiel.sedgkekdirkitqfhflGwpdvGvpdyp

REILNIFRV-------ARNSKSLVVHCSNGIGRSAAFVSWE
 ... . .         .. ...||||| |.||. ...  .
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivld
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1048-1181 1.1e-13 46.3 In-house 79-209 (284) alignment 
Range on Protein: 1048-1181
Range on HMM: 79-209/284.0
QTVDKFYQTIVQTGTEVVAMLCdfneegVEKCSSYFPLEKDGKQKFHNVNVctTNVQHpSADVVLRTLVItSYLGEKKKTHTVKHYSYKGWIEKNAPELP
 |.. |.. | .  .  . .|        .||| |.||. . |..  .|.|  . |.  |.. |.| . . |  |..|.  ... . ..|| ..  |. |
ntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkv..dsvee.seeyvvrdiel.sedgkekdirkirqfhflgwpdvgvpdyp

REILNIFRV-------ARNSKSLVVHCSNGIGRSAAFVSWE
 ... . .         .. ...||||| |.||. ...  .
sdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivld
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1047-1180 3.6e-13 44.3 In-house 101-241 (325) alignment 
Range on Protein: 1047-1180
Range on HMM: 101-241/325.0
VQTVDKFYQTIVQTGTEVVAMLCDFnEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPsADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAPEL
 .|.. ... ...  . || .|  . ..| ..|. |.| |    ..|  ..|    ...  .| | | | .     .| .| .|| . ...| .   .. 
tatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqv..kkGetrsvkqfqlqswddmGvqkr

PREILNIFRV-----------ARNSKSLVVHCSNGIGRSAAFVSW
|  ...| ..           .. |  ..||||.|.||. .|.| 
patlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl
0044763 (Phosphotyrosine protein) phosphatases II 1051-1242 4.3e-12 41.5 In-house 38-161 (178) alignment 
Range on Protein: 1051-1242
Range on HMM: 38-161/178.0
DKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDgkqkfhnvnvcttnvqhpsadvvlrtlvitsylgekkkthtvKHYSYKGWIEKNAPELPREI
 .... . . |  .. .|..  | | .||  |.| | .                                           .| . ..   ..|.|.. .
addlellkelgithivnlteelelgflkcdpywpeeag..........................................iqylhipipDhgvpdllehf

LNIFRVA-----RNSKSLVVHCSNGIGRSAAFVSWELCYHFvpvnfeicdfsvaefvyqkmirsldttstvNLDFLSLLTELRHSRPrAIHTPMQLA
|....       .. .  .|||| |.|||...|   |....                              .|.. . . ..|  || .. .| || 
lefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl..............................glsleeaielvrerRp.ivpnpgqlr
0048076 (Phosphotyrosine protein) phosphatases II 1116-1245 8.3e-12 40.5 In-house 33-136 (145) alignment 
Range on Protein: 1116-1245
Range on HMM: 33-136/145.0
VITSYLGEKKKTHTVKHYSYKGWIEKNAPELPREILNIFRVARN----SKSLVVHCSNGIGRSAAFVSWELCYHfvpvnfeicdfsvaefvyqkmirsld
|..    ..  .... .| | .|   ..|.|.. .|....  ..     .  .|||| |.||....|   |...                          
vlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll..........................

ttstVNLDFLSLLTELRHSRPRAIHTPMQLAFSI
     .... . | ..|  || |. .| || | .
....lgvsleealelvrsqrpgavpnpgqlrfly
subfamily_CG42327_pd Subfamily CG42327 1048-1173 2.7e-11 37.7 In-house 83-207 (319) alignment 
Range on Protein: 1048-1173
Range on HMM: 83-207/319.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEK--DGKQKFHNVNVcTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYkGWIEKNAPE
..  .|..|. .  . |.  |.|  | |...|. |.| ..  |... . .. | |   .      .. ||..     .|...  . || |  |.| . | 
dsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilv.tlkgrevkdryaistlllkrv..dkeesrelthywy.kwleaevPa

LPREILNIFRVARNS-KSLVVHCSNGIGR
 .. .. ..  .|.| ||  .. .| .  
eeaaliamllevrsslksysleqanelre
0049772 (Phosphotyrosine protein) phosphatases II 964-1245 4.4e-11 38.5 In-house 48-273 (314) alignment 
Range on Protein: 964-1245
Range on HMM: 48-273/314.0
EQDRYSDVLCGMdNRILIDedvcRRCYFKDQYINANYLELPngNRMILTQAPMSrtehfkpekdkkrknlyslsdeeeeisylvQTVDKF----------
. .|| |.|.   ||  ..    .  ..   ||||.|.  .  .. | ||.|..                               ||. |          
dknryldilpad.nrvilp....glpvsgsdyinasyvdgf..lkfIatqgple..............................itvvdfreepvlyyng

YQTIV--QTGTEVVAM---------------------LCDFNEEGvekcssyfplE----------KdgkqkfhnvnvcttnvqhpsadvvlrtlvITSY
.. ..  .  . .. |                     |... . |                     |                                |
wrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng..........neptaadlellk.............................eely

LGEKKKTHTVKHYSYkGWIEKNAPeLPREILNIFRVAR---NSKSLVVHCSNGIGRSA-AFVSWELCYHFvpvNfeicdfsvaefvyqkmirsldttstv
 .|. . . .|.. .  .   .|| |.. .. .... .   . . ..|||. |.||.. . |   |....   .                          
dpelferlgikylri.pvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll...g..........................

nLDFLSLLTELRHSRP-----RAIHTPMQLAFSI
 ...   | ..|  ||     ..|....|. |  
.vsleealedvrlkRpinpnpgfieqleqyefil
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1048-1179 4.4e-11 37.4 In-house 56-191 (237) alignment 
Range on Protein: 1048-1179
Range on HMM: 56-191/237.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNvQHPSADVVLRTLVITSyLGEKKKTHTVKHYSYKGWIEKNAPELP
 . | |.| . |    |. ||  . |   .||  |.| . |  . .  . |  .  .   .|  .|.|...   ...|.   .. | .  | ..  |.  
sscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaaygvltvslkk.keefsdytvrslllsk.rltlkevrlihqyqftswpdrgvpqqt

R-------EILNIFRVARNSKSLVVHCSNGIGRSAAFVS
        .|.|  .   .|   ..||| |.||.. |. 
aallrfrkniinrsphvsesgpwiihcsagvgrtgiflv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1033-1144 5.4e-11 36.9 In-house 66-180 (297) alignment 
Range on Protein: 1033-1144
Range on HMM: 66-180/297.0
LYSLSDEEEEISYL------VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCttNVQHPSADvvLRTLVIT-SYLGEKK
   . |||... |.       .||| |.. ... .  |..|.. ..|.| .||  |.|  .....|  .| |    . . | .    ....|   |  ..
yvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvve..flsstsde..fdrviltelqliyrs

KTHTVKHYSYKGWIEKNAP
..  |.|  . .| ..  |
esrvvrhvqflswpdhGvp
0048179 (Phosphotyrosine protein) phosphatases II 1127-1243 6.3e-11 37.7 In-house 46-136 (144) alignment 
Range on Protein: 1127-1243
Range on HMM: 46-136/144.0
THTVKHYSYKGWIEKNAPELPREILNIFRVARN----SKSLVVHCSNGIGRSAAFVSWELCYhfvpvnfeicdfsvaefvyqkmirsldttsTVNLDFLS
.... .| . .|   ..|.|.  .|....  ..    ..  .|||| |.||....|   |..                              . .|.. .
eregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk..............................klglslee

LLTELRHSRPRAIHTPMQLAF
 | ..|  || |. .| || |
alalvrsrrpgavpnpgqlrf
subfamily_CG7180_pd Subfamily CG7180 1048-1192 8.9e-11 36.0 In-house 96-255 (296) alignment 
Range on Protein: 1048-1192
Range on HMM: 96-255/296.0
QTVDKFYQTIVQTGTEVVAMLCDFNEEGVeKCSSYFPLEKdgKQKFHNVNVCTTNVQHpSADVVLRTLVITSY--------LGEKKKTHTVKHYSYKGWI
.|||.|.. . . ... | .|..  .    .. ||.| .   |... .. | ......  |... ||. .|           ..| .| .||.. .. | 
etvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekq.yanlkirtfkltkkivalteqekqvkaetRivklfqlteWe

E-KNAPELPREILNIFRVARN----------SKSLVVHCSNGIGRSAAFVSWELCYHFVPVNFE
  .. |     .... | .|            . .||..|.| .|| .... . .   |  . |
ledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeee
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1050-1179 9.3e-11 36.3 In-house 64-192 (239) alignment 
Range on Protein: 1050-1179
Range on HMM: 64-192/239.0
VDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlekDGKQKFHNVNVCTTNVqHPSADVVLRTLVItSYLGEKKKtHTVKHYSYKGWIEKNAPELPRE
   |.. . |    |. ||  . |   .||  |.|   |   |. |. |   .     || ..||.|. | .|. .. . | .| .  | .|  |.    
sgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrkt.evfadyiirtfvm.sqvgqtee.ryvyqyhftvwpdkgvpqyata

ILNIFRV-ARN----SKSLVVHCSNGIGRSAAFVS
.| . |  ...    ..  |.||| |.||. ||. 
vlglrrkitkdslpgarpwvihcsagvgrtgaflv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1050-1179 1.1e-10 36.1 In-house 65-193 (239) alignment 
Range on Protein: 1050-1179
Range on HMM: 65-193/239.0
VDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlekDGKQKFHNVNVCTTNVqHPSADVVLRTLVItSYLGEKKKtHTVKHYSYKGWIEKNAPELPRE
   |.. . |    |. ||  . |   .||  |.|   |   |. |. |   .     || ..||.|. | .|. .. . | .| .  | .|  |.    
sgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycnlrvtlrkt.evfadyiirtfvm.sqvgqtee.ryvyqyhftvwpdkgvpqyata

ILNIFRV-ARN----SKSLVVHCSNGIGRSAAFVS
.| . |  ...    ..  |.||| |.||. ||. 
vlglrrkitkdslpgarpwvihcsagvgrtgaflv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1046-1185 7.3e-10 33.3 In-house 101-237 (315) alignment 
Range on Protein: 1046-1185
Range on HMM: 101-237/315.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkdgKQKFHNVNVCTTNVQHpSADVVLRTLVITSylgeKKKTHTVKHYSYKGWIEKNAPE
.|..|. |.. . .     . || .  |.  .|.  |.| .   |  . .. |   . ..   ..  ||| ...    ... ..|  . |  | . . |.
nvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseev.nteytvrtlsvvf....gdnirevvqlhytswpdmgvpk

LPREILNIFRVAR-----NSKSLVVHCSNGIGRSAAFVSWELCYH
    ..|..| ..     .  ..|||||.|.||. .|.. .   .
ytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1047-1182 7.5e-10 33.3 In-house 14-156 (198) alignment 
Range on Protein: 1047-1182
Range on HMM: 14-156/198.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQhPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.  |.| . .||.  . |. | . .     . |.|  . |  |. ...|.|  .    .| .. .|..|.       |  . || .  | || .|..
retladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnv

P---------REILNIFRVARNsKSLVVHCSNGIGRSAAFVSWEL
          ||. . .   ..   ..||||.| | .  ||. ..
alfvgfvvasrevskkyeqekd.apvivhcsdgqgftgvfvaldi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1047-1182 7.8e-10 33.2 In-house 15-157 (199) alignment 
Range on Protein: 1047-1182
Range on HMM: 15-157/199.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQhPSADVVLRTLVITSYLGEKKKTHTVKHYSYKGWIEKNAPEL
 .|.  |.| . .||.  . |. | . .     . |.|  . |  |. ...|.|  .    .| .. .|..|.       |  . || .  | || .|..
retmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqftswkekttpnv

P---------REILNIFRVARNsKSLVVHCSNGIGRSAAFVSWEL
          ||. . .   ..   ..||||.| | .  ||. ..
alfvgfvvasrevskkyeqekd.apvivhcsdgqgftgvfvaldi
subfamily_eak_pd Subfamily eak 1050-1258 7.8e-10 32.6 In-house 106-311 (332) alignment 
Range on Protein: 1050-1258
Range on HMM: 106-311/332.0
VDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQHpSADVVLRTLVITSylGekKKTHTVKHYSYKGWIEKNAPELpRE
|  |.| ...  .  . .| .  |...||   ||| .   . ||  ..| . .  .  . .  | |...   |   .|| |.|| . || | . | . ..
vfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkefvk.rniletrllelsk..G..nethrvlhykvfGwtettlpky.ed

ILNIFRVARNSKSLVVHCSngigRSAAFVSWELCYHFVP-VNFEICDFSV-----AEF-VYQKMIRSLDTTSTVNLDFLSLLTELRHSRPRAIHTPMQLA
 | ...| ..   | .       .|| . |    |.  |  .  |   .        | | . .|| .|   .       |.   .. |  .. . .| .
flalrkvmkevGvlllivm....ksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhs

FSIMMVLDFVMNNFPK
|   .|||....  ..
fiyeivldyllrrnnr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1046-1183 8.5e-10 32.9 In-house 89-233 (287) alignment 
Range on Protein: 1046-1183
Range on HMM: 89-233/287.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYlgEKKKTHTVKHYSYKGWIEKNAP-
.  || .|.. ...| . .|...    ||.  ||  |.| |..   .     |   . .  . .   |.| .     | .... || . .  | .| .. 
iaatvrdfwravletrsasvitmtreveearlkcykywP.erevPmrvGGysvvlldydikePeygvralrlidl..etrearvvkqldllswPdkvlaP

E---LPREILNI------FRVARNSKSLVVHCSNGIGRSAAFVSWELC
    | | .|..       | | .   ||||.. |||||  ...   .
tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvl
subfamily_egg_pd Subfamily egg 1047-1183 7.6e-09 29.7 In-house 93-224 (307) alignment 
Range on Protein: 1047-1183
Range on HMM: 93-224/307.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEgvEKCSSYFPLEKDGKQKFHNVNVCTTNVQHPSADVVLRTLVITSYLGEKKKTHTVKHYSYKgWieKNAPEL
  ||| |.. . |   . . ||    |   |.|  |.|  ..   ..   ..  .|..  |.   | ..     .| ...   ..|. .  .  .|. ..
kntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqgd.v..nnssdv

pREILNIFRVARN-SKSLVVHCSNGIGRSAAFVSWELC
    |...| .|| ||  ||.. .|. ..|..|. |. 
.ysplrvlrklrnlskpvvvqdilGvskaatlvaieia
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1046-1180 9.2e-09 29.4 In-house 94-246 (301) alignment 
Range on Protein: 1046-1180
Range on HMM: 94-246/301.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEKDGKQKFHNVNVCTTNVQ-HPsaDVVLRTLVITSYLGEK-------------KKTHTVK
. .|.  |.. |.|  .  . |... .|.  .||  |.|  .  ...| ...|  .| | .|  | |.| | .. . | .             |....| 
mkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyP..dfvirqlnvkiqdgsnngyierkfkvksdksswdvl

HYSYKGWIEKNAPELPREILNI-----FRVARNSK-SLVVHCSNGIGRSAAFVSW
 .    | .      || .|..      |  . ..  .|||||....||  ..| 
qlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1047-1178 1.3e-08 28.9 In-house 92-227 (312) alignment 
Range on Protein: 1047-1178
Range on HMM: 92-227/312.0
VQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPlEKDGKQK--FHN--VNVCT-TNVQHPSADVVLRTlVITSYLGEKKKTHTVKHYSYKGWIEK
 .|. .|.|  .  |.  . .|| | |.| |||. |   .  |  .   |    . ||  ..   | | .    |.   .    .   ..|| .  | ..
entcthfwqlalslgstsiillcgfvedgsekcakyis.divgfvdledhrvyteycteieiggkskdkithr.vlkvvvkatgqesklnhyqwaswpdh

NAPELPREILNIFR-VARNSKSLVVHCSNGIGRSAAFV
  |.     | ..  | .. | .. ||| |.||. ...
gmpdscdtalrllsavkkdkkpviahcsagvgrtgtla
MutS_III MutS domain III 116-255 3e-07 17.8 Pfam-A 48-150 (204) alignment 
Range on Protein: 116-255
Range on HMM: 48-150/204.0
DTAGIEEFQNAVKNFIG-AAADVEKYSNLEKLTDVDIMYARplIYTLKTSIENLAKSYSSINSFDDFekirnpsefvdpiskivsgykkynasrttierd
| | |.. ..||. ...  |.  .  . |.|| |.. . .|  ... . |.. |.. .|........                                 
diaeinaRldaveallenealredlreaLkklpDlerllsr..lalgrasprdllalrstlkalpel.................................

gnfAKGMQSNANNMKRLENVASVFEGLGSFVKNLQAVIDVR
   .| ..|. . |. ||...| .. | ...| |. .|| .
...kklesselesmelleallsklnpleellklledaided
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1046-1179 3e-07 24.7 In-house 81-211 (267) alignment 
Range on Protein: 1046-1179
Range on HMM: 81-211/267.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEgveKCSSYFPLEKDGKQKFHNVNVCTtNVQHPSADVVLRTLVITsYlgEKKKTHTVKHYSYKGW-IEK-NA
| .|. .|.. | . .  |. .|    ..   .   ..| .    .|.... |   ....   |  . || .  .  ... .| |  | || | |.  | 
lkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqakkyqdltveh.slekeendyqiitlelk.f..knesahnvtlyyykkwnintnnk

PELPR--EILNIFRVARNSKSLVVHCSNGIGRSAAFVS
| |     ||   ..   .. |||.||.|.||| .|. 
pylkplfgilaknqlengnrPlvvacsdGvGrsGtflv
SID-1_RNA_chan dsRNA-gated channel SID-1 764-885 3e-06 12.9 Pfam-A 99-212 (570) alignment 
Range on Protein: 764-885
Range on HMM: 99-212/570.0
TLQPSQTVSVTTTEEP-MDESTNLMIFIGIGCGIVLVSaLIVAVVCFYKRNKianddMEQGTKIEKEKIARELAAQEAQNIEaEKKKKEIKDLEakVDYE
  . |.|..||..|.  . ..|...... . . ...|  |..|...  |. |     . . ..|..|  . |  |.. |. | ......... .  .  .
nrtksitlkvtklesieykkatlaivivllsllllfvv.lviaiikekkelk.....avskeiissepsgseqramdlqeke.seedssleeed..ilka

KQKGEKIKEEAEKEIQDHRKKVE
.|. | |.|.|. ...|  .| |
eqeievirekaaltvsdlsrkde
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1046-1263 4.2e-06 20.5 In-house 103-296 (310) alignment 
Range on Protein: 1046-1263
Range on HMM: 103-296/310.0
LVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFPLEkDGKQKFHNVNVctTNVQHPSADVVLRTLVITSY-----LGE---KKKTHTVKHYSYKG
| .|.  |.. | |  .| . .||   |||  || .|.|      . .  . |  ||.   | .  .  | .|       . |   . |   |.   .  
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl.gvtetygcirv..tnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpn

WIEKNAPELPREILNIFRVAR-NSKSLVVHCSNGIGRSAAFVswelcyhfvpvnfeicdfsVAEFVYQKMIRSLdttstvNLDFLSLLTELRHSRPRAIH
| ..  |.     .    .|.      ||||| |..|  . |                     .. ..|. | |      ..|.  . |||..||   | 
wpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvv...................alklkidkldrgl......kvdaeevktellksraiciq

TPMQLafsimMVLDFVMNNFPKGEMEA
|..|      ...|.|.  | .|| | 
telqy.....liidrvriifargetev
DUF1510 Protein of unknown function (DUF1510) 790-885 4.9e-06 15.3 Pfam-A 16-114 (217) alignment 
Range on Protein: 790-885
Range on HMM: 16-114/217.0
IGIGCGIVLVSALIVAVVCFY---KRNKIANDDMEQGTKIEKEKIARELAAQEAQNIEAEKKKKEikD--LEAKVDYEKQKGEKIKEEAEKEIQDHRKKV
. |  .||.|  .|||.  .    | .| ..|. |. .. ..||   |   .|...  ....|..  |   | | . .... |. ||..|.| ... |..
LniaiaiVvvlivivaaqllvgnskskkasadeeeeeksedeekteeeevkeeekeaakdedked..dsesekkdeeseeeeeeekekkeeeseedeket

E
|
e
IncA IncA protein 790-879 6.8e-06 15.6 Pfam-A 40-117 (191) alignment 
Range on Protein: 790-879
Range on HMM: 40-117/191.0
IGIGCGIVLVSALIVAVV--CFYKRNKIANDDMEQGTkiekekiarelaaqEAQNIEAEKKKKEIKDLEAKVDYEKQKGEKIKEEAEKEIQD
. ... |.|...|.....  ...|...    |...                 ....|  . ......|| ... . .. .. ..| |.. .|
llgivliAlgvvLlalgllllllkapvqseedekiee..............srlqeelsesesqlseleeeleqleerlaeleseledleed
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 991-1088 9e-06 19.2 In-house 88-187 (349) alignment 
Range on Protein: 991-1088
Range on HMM: 88-187/349.0
FKDQYINANYLELPNGNRMIltqapmsrtehfkpekdkkrknlyslsdeeEEIS---YLVQTVDKFYQTIVQTGTEVVAMLCDFNEEGVEKCSSYFP---
  |.|||||||.|.. .                                   |.    |  ||| ||. |.  | ..|  | | .|...|||  |.    
klddyinanylkltrisvek..............................kyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels

--------------------------LEKD
                           .||
ysnitvklqnsslyianvqGnslrvstvkd