Gene M05B5.1 in Caenorhabditis elegans

Synonym: CELE_M05B5.1, M05B5.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf17
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP126_AA protein Get Run
CeleP126_AA_79-412 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 79-420 2.9e-221 728.0 In-house 1-347 (347) alignment
Range on Protein: 79-420
Range on HMM: 1-347/347.0
LCKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTnPEKSKMGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIR
.|||.||.|||||.||||.|||||||||.|..||||...|||.|||||||||||||. |||||...|||||.|||||||.|||||..|||||||||.|.|
fckylldikeaslstyfdenlanyspskftsvewekslsknrskdvklidatrvvls.peksknsraddvetyinashikfdnaskeyiltqyplpdtvr

DFWKMVYVTKVTQVITIFEPIKDEAIEEFANfpAPASPVPPPPTASSKDIGSSP---DQQPREREQIEIKSIRCDNHLHQ-SFFPLSTDHYLNLEGWLIN
||||||.|||||||.||||||||||||||||  |..|.|.|.||||||||||||   ||..|||||||||||||...||. |||||.|||||||.|||||
dfwkmvsvtkvtqvvtifepikdeaieefan..atlslvapaptasskdigsspvpidqiarereqieiksircesnlhrssffpletdhylnlkgwlin

TRAVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPT----VGKQPPVIVMCDLGLDRSATVVLTSIIIEQ
|||||||||.|||||||||||||.|||||||||||||||||||.||||.|||||||||||||||..    ..|..||.||||||||||||||||||||||
travevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieq

VLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLNE
|||||||||||||.|||||||||||||||.||||||||||||||||.|||
vldgktpdcddlfkkmrdqragvftmsifytyairaalfylklklqtlne

DSPc_SM00195 91-412 4.4e-72 237.9 In-house 2-263 (263) alignment
Range on Protein: 91-412
Range on HMM: 2-263/263.0
LNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVT
|...|.  ....||...| .|..||..||| |.....| ||| |...||.      . . ||||..|...| . .||.||.|||||..|||.||. .||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk......egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

QVITIFEPIKDEAIEEFANFPAPAspvpppptasskdigsspdQQPREREQIEIKSIRCDNHLhqsffplstdhylnlegwlintravevdqrckNWMNK
......|. ... ..   ..|  .                   ... . ..|..| ......                                 .....
iivmlteeeengkekcdrywpees...................ggketfgkisvklvevekkk................................deiil

YTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQR
.|.|. ..|..|......|....||....||. |.||.|.||  |..| .   ..|..|.|. |..|..|.|...||.... ..|..|........|.||
rtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

AGVFTMSIFFTYAIRAALFYLK
.|..... .......|.|.|.|
pgmvqtleqYlfiyeaileyik

PTPc_SM00194 91-412 4.4e-72 237.9 In-house 2-263 (263) alignment
Range on Protein: 91-412
Range on HMM: 2-263/263.0
LNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVT
|...|.  ....||...| .|..||..||| |.....| ||| |...||.      . . ||||..|...| . .||.||.|||||..|||.||. .||.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekk......egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvk

QVITIFEPIKDEAIEEFANFPAPAspvpppptasskdigsspdQQPREREQIEIKSIRCDNHLhqsffplstdhylnlegwlintravevdqrckNWMNK
......|. ... ..   ..|  .                   ... . ..|..| ......                                 .....
iivmlteeeengkekcdrywpees...................ggketfgkisvklvevekkk................................deiil

YTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQR
.|.|. ..|..|......|....||....||. |.||.|.||  |..| .   ..|..|.|. |..|..|.|...||.... ..|..|........|.||
rtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqR

AGVFTMSIFFTYAIRAALFYLK
.|..... .......|.|.|.|
pgmvqtleqYlfiyeaileyik

0036941 (Phosphotyrosine protein) phosphatases II 80-419 5.1e-58 192.1 In-house 4-285 (297) alignment
Range on Protein: 80-419
Range on HMM: 4-285/297.0
CKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRD
....  .  | | ..|.  | .. . ...  ....|..||| ||.   | |||.|           |.  .|||||.. . . .  .|.||.|||.|. |
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl..........ddegsdYinAsyvdgydlkrkfIatqgPlpntved

FWKMVYVTKVTQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLSTDHYLNLEGWLINTRAVE
||.||.  .|| .... |.. .. .                                                  ....|| ....|. ... .... ||
FWrmvweqnvtvIvmltelvelgrek................................................caqywpleegesltygdftvtllsve

VDqrCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVL---DGKT
|.   ....  .|.||.  |..|  . ... .|.||. . |.... .|..... |..  .   ...||.|.|  |. ||.|...  ....|.      ..
vv..llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel.vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkegg

PDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLN
.|  ....|.|.||.|....  .. . ..| |..|| ||....
vdileavkklReqRpgavqtleqyrflyeallellkkkltkep

0040438 (Phosphotyrosine protein) phosphatases II 81-419 4.7e-56 185.7 In-house 7-284 (317) alignment
Range on Protein: 81-419
Range on HMM: 7-284/317.0
KYILDMKEASLnTYFD---ANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTI
...||..  .  |..     .| ..... ... |...| .||| .|. . |..||.|.....      |   .|||||.. . | .. .|.||.|||.|.
lalldllksdf.talleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg......dldsdYInAsyvdgpnlkrkfIatqgPlpntv

RDFWKMVYVTKVTQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRA
 |||.||.  .|| .... |.  .. .                                                  . ..||  ...|. ... .... 
edFwrmvweqgvtvivmLteleelgrek................................................caqYwpl..getltygdftvtlls

VEVdqrcKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTP
.|.    .. .. .|.||. .|.||  . ... .|.||  . |.. . .|....|  .  .   ... ||.|.|  |..|..|...  ...||.  ....
eee....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggv

DCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLN
| .. ....| ||.|....  .. . ..|.|.||| ||.. .
dveeavkelreqRpgavqtpeqyrflydalleylkrkltlep

0050432 (Phosphotyrosine protein) phosphatases II 89-418 1.6e-54 180.7 In-house 42-306 (308) alignment
Range on Protein: 89-418
Range on HMM: 42-306/308.0
ASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpaDDVEGYINASHIRFD--NASTDYILTQYPLPSTIRDFWKMVYV
  |...| . |... . .... ....|..||| ||.   | .||.|           |.  .|||||....   . .  .|.||.|||.|. |||.||. 
glleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl...........degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvwe

TKVTQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLSTD-HYLNLEGWLINTRAVEVdqrcK
 .|. .... ... .. .                                                    ..||... ..|. ... .... .||    .
qnvrvIvmLtklvengrek................................................caqYwplelgggsleygkftvtllseev....l

NWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
... ..|.|..  |..|  . ... .|.||  . |.... .|.....  |       ...|..|.|  |. |..|...  ...||.  ....|  ....|
ddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkk

MRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCL
.| ||.|...    . . .||.|.||||||..|
lReqRpgmvqtpeqylflyralleylklkltkl

0047943 (Phosphotyrosine protein) phosphatases II 95-411 1.3e-51 171.1 In-house 18-272 (273) alignment
Range on Protein: 95-411
Range on HMM: 18-272/273.0
FDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpA----DdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVT
|.. | .. . .... ....| .||| ||.   | .||.|               |    |||||.... | .  .|.||.|||.|. |||.||.  .|.
felllslkplltysvallpenkdknrykdilpydhsrvkl..........gdggsd....yinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

QVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLSTDH-YLNLEGWLINTRAVEVdqrcKNWMN
 .... |.. .. .                                                 .  ..||. .. .|. . . .... .|.    |... 
viVmLtelvelgrek................................................caqYwpleggelsltygkftvtllseet....kddyt

KYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQ
..|.|..  |..|  . ... .|.||  . |.... .| .... |..   .. ...||.|.|  |. |..|...  ....|.  ....| .......|.|
vrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel.vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

RAGVFTMSIFFTYAIRAALFYL
| |...   .. . ..|.|.||
Rpgmvqtpeqyrflyealleyl

0051299 (Phosphotyrosine protein) phosphatases II 90-412 4.6e-51 169.4 In-house 24-287 (288) alignment
Range on Protein: 90-412
Range on HMM: 24-287/288.0
SLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKV
 |   |.. |... . ....  ...|..||| .|.   | .||.|.....      ..  .|||||.|.. | .  .|.||.|||.|. |||.||.  .|
glleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg......vegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnv

TQVITIFEPIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRAVEVdqrcKNWMN
. .... ... .. .                                                    ..||  ...|... . .... .||    .. . 
rvIvmltklvelgrek................................................caqYwpl..ggsltygditvtllseev....lddyt

KYTVEVVAD----GCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
..|.||.      |..|  . ... .|.||  ..||... .|...|.  |  .    ...||.|.|  |..|..|...  ...||.. ....|  .....
vrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkr

MRDQRAGVFTMSIFFTYAIRAALFYLK
.| || |....   . . ..|.|.|||
lreqRpgmvqtpeqyrfvyealleylk

0043336 (Phosphotyrosine protein) phosphatases II 98-411 1.2e-49 164.7 In-house 28-277 (278) alignment
Range on Protein: 98-411
Range on HMM: 28-277/278.0
NLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
.| .. .  ... ....|..|||.||. . | .||.|..       . |   .|||||.. . | ....|.||.|||.|. |||.||.  .|| .... |
ellsfkldtysiallpenkdknrykdilpydhsrvklsl......lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

PIKDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPlstDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVA
.  .. .                                                  . ..|   ...|. ... .... .|.    ....  .| ||. 
lvelgrvk................................................caqYwp...ggsltygdftvtllkeeh....lddytvrtlevtn

DGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMS
 |..|  .  .| .. ||  . |.... .| ...|  .  .    .. ||.|.|  |..|..|...  ...||. .....| .. ....| ||.| ... 
lgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtp

IFFTYAIRAALFYL
 .. . ..|.|.||
sqyrflyealleyl

0046845 (Phosphotyrosine protein) phosphatases II 105-419 1.6e-49 164.2 In-house 18-282 (284) alignment
Range on Protein: 105-419
Range on HMM: 18-282/284.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHIRFD-----NASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
 ....  ...|..||| ||.   | .||.|......     ..  .|||||....      . .  .|.||.|||.|. |||.||.  .|. .... |..
lslsvallpenlsknRykdilpydhsRVklksldgd.....ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelv

KDEAIEefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLStDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVADG
 .. .                                                 .  ..||. ...|..... .... .||    |... ..|.|..  |
engrek................................................caqYwple.gevltygdftvtllseev....kddytvrtleltnlg

-CSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK---TPDCDDLFRKMRDQRAGVFT
 ..|  . ... .|.||  . |.... .|...|. |.|. . .....|..|.|  |. |..|...  ...||.  ..   ..|  ......|.|| | ..
ytgesrtvthfhytswpdhgvppspedlleflrl.vrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

MSIFFTYAIRAALFYLKLKLQCLN
.   . . ..|.|.||||||..|.
tleqyrfvyealleylklkltlle

0045450 (Phosphotyrosine protein) phosphatases II 103-411 1.8e-48 161.2 In-house 43-304 (307) alignment
Range on Protein: 103-411
Range on HMM: 43-304/307.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHI--------RFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
 . .... ....| .||| ||. . | |||.|.....|     ..  .|||||..         . . .. .|.||.|||.|. |||.|..  .|| ...
llgeysiallpenkdknrykdilpydhtRVklssldgs.....ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivm

IFEPIKdeaieefanfpapaspvpppptasskdigsspdqqprereqieiksirCDNHLHQSFFPLStDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVE
. |..                                                 ...     ..|.. ...|. . . .... .|.    .. .  .|.|
ltelve................................................lgrekcaqywPde.geeltygnftvtllseeh....ldgytvrtle

VVAD-GCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKeSSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT---PDCDDLFRKMRDQR
|    |..|  . ... .|.||  . |.... .|.....  |    . .|. ||.|.|  |..|..|...  ....|. ...|   .| .. ....|.||
vtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk.aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR

AGVFTMSIFFTYAIRAALFYL
 |...   .. . ..|.|..|
pgavqnpeqyrflyeallell

0039614 (Phosphotyrosine protein) phosphatases II 98-416 5.9e-48 159.2 In-house 40-294 (297) alignment
Range on Protein: 98-416
Range on HMM: 40-294/297.0
NLANYSPSkCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgPADDVEGYINASHIRFDNA-STDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
.| .. |. ... ....|..||| ||.   | .||.|. ..       |    |||||.. . .  . ..|.||.|||.|. |||.||.  .|| .... 
ellslkpd.ysiallpenkdknrykdilpydhsrvklkped.....gvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLt

EPIKDEaieefanfpapaspvpppptasskdigsspdqqprereqieiksircdNhLHQSFFPLSTDhylNLEGWLINTRAVEVdqrcKNWMNKYTVEVV
... ..                                                .   ....| ...   . ... .... ||.    .. .. .| ||.
klvelg................................................r.kcaqywpeegg...tygdftvtllkveh....ldgytvrtlevt

ADGCSeaTFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTM
 .|.|   . ... .| ||. . |.... .| ....  .  . . .|. ||.|.|  |..|..|...  ...||.  ....| .. ....| || |....
nnges..rtvthfqytgwpdhgvppslellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqt

SIFFTYAIRAALFYLKLKLQ
  .. . ..|.|..|| ||.
psqyrflydallellkrklt

0045098 (Phosphotyrosine protein) phosphatases II 93-413 6.8e-45 149.0 In-house 11-274 (278) alignment
Range on Protein: 93-413
Range on HMM: 11-274/278.0
TYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVltnpekskmgpaddveGYINASHIRFDnaSTDYILTQYPLPSTIRDFWKMVYVTKVTQV
..|. .|. ..||..|.. ...|..||| ||.  .| .||.                .|||||.|..   .. .|.||.|||||. |||.|..  ..| .
lefefllllgipseitpalylgnldknRykdilpydhsrVk................dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvi

ITIFEPIKDEaieefanfpapaspvpppptasskdigsspdqqprereqieiksircdN-HLHQSFFPlstDHYLNLEGWLINTRAVEVDqrCKNWMNKY
... | . ..                                                . . .| . .   ...|. ... ...  .||    . .. ..
vmltelvelg................................................rekcaqywpe...ggsltygdftvtllseevl..ddytlrtl

TVEVV--ADGCSEATFAKVYNCTTWPWKSYPDDV--KKVLALVRAPVKESS----------PTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVldGKTP
.|. .   .   |  . .......||  . |..   | .| |..   .  .           . ... ||.| |  |..|..|.|.  ...|..  ... 
lvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggv

DCDDLFRKMRDQRAG-VFTMSIFFTYAIRAALFYLKL
| .. ....| || | ....  .. . ....| .|. 
dlleavkelrsqRpglavqnleqyrflyefllelllr

0040439 (Phosphotyrosine protein) phosphatases II 106-411 1.6e-44 147.8 In-house 2-246 (249) alignment
Range on Protein: 106-411
Range on HMM: 2-246/249.0
KCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIE
.... ....|..||| .|.   | .||.|.  ..          .|||||.| . . ....|.||.|||.|. |||.|..  ..| .... ..   . . 
eysvallpenkdknrypdilpydhsrvklsilpg......lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrek

efanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVADGCSEATF
                                                 . ..||  ...|. ... .... |||    |...  .|.|..  ...|   
................................................caqywpl..ggsleygdftvtllsvev....kddytvrtleltnlydgesrt

AKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIR
 .....| ||  . |.... .|....|  |  . . .|. ||.|.|  |..|..|...  ...||.   .. | .. ....|.|| |....  .. . ..
vlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflye

AALFYL
|.|..|
allell

0042113 (Phosphotyrosine protein) phosphatases II 107-412 3e-43 143.4 In-house 1-244 (245) alignment
Range on Protein: 107-412
Range on HMM: 1-244/245.0
CTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKMGPaddvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEe
... ....|..||| .|. . | |||.|.... .   .      |||||.. ... .  .|.||.|||.|. |||.|..  ..| .... |.  .. .  
ysvallpenkdknrysdilpydhtrvklspdggdldsd......yinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvk.

fanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlHQSFFPLstDHYLNLEGWLINTRAVEVdqrcKNWMNKYTVEVVADGCSEATFA
                                                . ..||  ...|. ... .... .|.    ....  .|.||. .|..|  . 
...............................................caqywpl..gesltygdftvtllseeh....lddytvrtlevtnlgddesrev

KVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
 .| .. ||  . ||... .| ....  |  .   ... ||.|.|  |..|..|...  ...||.   .. . .. ....|.|| |....  .. . ..|
ihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

ALFYLK
.|..||
llellk

0037934 (Phosphotyrosine protein) phosphatases II 107-411 1e-29 99.3 In-house 2-242 (243) alignment
Range on Protein: 107-411
Range on HMM: 2-242/243.0
CTFNEWEKNVNKNRTKDVKLIDATRVVLtnpekskmgpaDDvEGYINASHIRFDNastDYILTQYPLPSTIRD----FWKMVYVTKVTQVITIFEPIKDE
...  .. |..||| .|. . | .||.|           .. ..||||..|.  .    .|.||.|||.|. |    ||.|..  ..| .... |..  .
fsiallpenlsknrysdilpydhsrvkl...........eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElg

AIeefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhLHQSFFPlstDHYlNLEGWLINTRAVEVdqrCKNwMNKYTVEV-VADGCS
..                                                    ..|   . . . ... ...  .|.   ... .  .|...   |   
re................................................kcaqywp...gev.tygdftvtllseeh...ldd.ytvrtlllenldldd

EATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSP-----TVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVldgkTPDCDDLFRKMRDQRAG-VFT
.  .   | .. ||  . ||... .|.....  .  .      .  .. ||.|.|  |..|..|...  ......    . | .. ....|.|| | ...
ltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavq

MSIFFTYAIRAALFYL
   .. . ..|.|..|
tpsqyrflyeallell

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 113-412 1.9e-27 91.0 In-house 26-269 (274) alignment
Range on Protein: 113-412
Range on HMM: 26-269/274.0
EKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIfEPIKDEAI-EEFANF
 .. .||| |..   . .||.|.. . .     |.   |||| .|. .|. |. |. || |||.|. |||.|.| ..|. .. .   .|..        |
fgsqtknryktilPnensrvllesesse.....dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivml.tklkeaneqkCavyf

PapaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylN-----L-------EgwlintraveVDQRCKNWMNKYTVE-VVA
|                                                       .     .       |          .  . ..  |.|.|. .| 
P.......................................................daedyeiserygdve..........ikvekiverndysvrklvl

DGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMS
  ...    | |  | || .  |||....| ||.   .. . .  |  ||.| |  |. |    . .|| . |. . .. |   .  ..| .| |.   |
kylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqts

IFFTYAIRAALFYLK
  . .  ||   |||
eqyelihralclylk

subfamily_PTPRB_pd Subfamily PTPRB 106-392 4.2e-25 83.4 In-house 42-266 (293) alignment
Range on Protein: 106-392
Range on HMM: 42-266/293.0
KCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKMgpaDDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIE
.....| ..| .||| ...   |..|| |.. ....    .|   ||||..|.  |.  ..| || |||.|. |||.||. .|.. .. . . .    . 
avkaaelavnraknrytnilpydhsrvkLaalkdesg...sD...YinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvk

EFANFPAPaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylnleGWLINTRAVEVDQRCKNWMNKYTVE-VVADGCSEAT
    .||                                                            ..   ..|.   .. ......  .     .| .
CeeYWPad........................................................eepvlyGdikvtlvaeeeledwvirelkiekekeer

FAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAG
  . |. |.||    |.. |..|..||. |.|.  .  .. |..| |  |. |. | .    ..... .  . |   .  ..| .|. 
kvrqyhftsWpdhgvPektktlldfvrt.vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnl

0041856 (Phosphotyrosine protein) phosphatases II 115-411 6.5e-22 73.4 In-house 1-171 (182) alignment
Range on Protein: 115-411
Range on HMM: 1-171/182.0
NVNKNRTKDVKLIDATRvvltnpekskmgpaddVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFepikdeaieE----Fanf
|..|||..|.  .| .|                .  ||||. ....  .|..|.|| ||.||. ||..|..  ..| ....          |        
nldknrysdilpydhsr................dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp...

papaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseA---TFAK
                                                                                                    
............................................................................................ellerlgi

VYNCTTWPWKSYPDdVKKVLALVRAPVKessptvgKQPPVIVMCDLGLDRSATVVLTSIIIEQvldgkTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAA
 | .. ||  . || . ..|.....  .       .. ||.| |  |..|..|.|.  .....       . .. .. .| .| |....  .. .  .|.
qylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlal

LFYL
|..|
lell

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 248-416 1.5e-21 71.1 In-house 129-290 (302) alignment
Range on Protein: 248-416
Range on HMM: 129-290/302.0
RCDNhLHQSFFPLSTDHYLNLEGWLINTRAVEVDQRCKnwmNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVkeSSPTVGKQPPV
 ...   . .||. .. |.. .   .|.| ||  .  |   ..|..||. .|||.. .|.|| .| |. |. |. . .. . .   |     ..  . ..
elkk.tlselfpkksgdykeygkmfvNnrkVekaeeek...tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaak.v..fakkikadent

IVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQ
...   |  | ....   . .|.. .|| |   .. ...| ||. .    . ..   .|.|.|.| |..
vivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt

Y_phosphatase Protein-tyrosine phosphatase 115-201 4.1e-20 67.6 Pfam-A 1-79 (235) alignment
Range on Protein: 115-201
Range on HMM: 1-79/235.0
NVNKNRTKDVKLIDATRVVLtnpeKSKMGPADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKD
| .||| ||.  .| ||| |    |.. || |    ||||....  . .  .|.|| ||.||| |||.||.  ||. .... .  . 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek

Y_phosphatase Protein-tyrosine phosphatase 115-201 4.1e-20 67.6 In-house 1-79 (235) alignment
Range on Protein: 115-201
Range on HMM: 1-79/235.0
NVNKNRTKDVKLIDATRVVLtnpeKSKMGPADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKD
| .||| ||.  .| ||| |    |.. || |    ||||....  . .  .|.|| ||.||| |||.||.  ||. .... .  . 
nkkknRykdilpydktrvkl....kgsegpsd....YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleek

PTPc_DSPc_SM00012 307-408 4.3e-19 64.0 In-house 3-104 (105) alignment
Range on Protein: 307-408
Range on HMM: 3-104/105.0
KVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDG-KTPDCDDLFRKMRDQRAGVFTMSIFFTYAIR
|.| .|.||... |......| |.|| ||..    ....||.|.|  | .|..|.|. .|...|. .. |..|  ......|.||.|....   . . .|
khyhytgwpdhgvPeesdsilellra.vkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AAL
| |
all

subfamily_PTPN12_pd Subfamily PTPN12 110-194 7e-18 59.5 In-house 35-113 (290) alignment
Range on Protein: 110-194
Range on HMM: 35-113/290.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmgpaddVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
 | |.||.||| ||.   | .||.|.. |...       ..||||..|.  . .. || .| ||| |. |||.|.. ..|. |. 
gekeenvkknrykDilPydksrvelskieeee......gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvm

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 110-206 8.5e-18 59.6 In-house 51-140 (298) alignment
Range on Protein: 110-206
Range on HMM: 51-140/298.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVtQVITIFEPIKDEAIEE
 . ..| .|||  |.  .| .||||.. .      ||.   |||||..   . .. .|.||.||..|. |||.||   .. ..| .......    .
arkpenkkkNRyadiialdssRvvLeked......adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedi.gtiVmltnleeldktk

subfamily_PTPRD_pd Subfamily PTPRD 103-195 1.2e-17 58.8 In-house 36-122 (564) alignment
Range on Protein: 103-195
Range on HMM: 36-122/564.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
. ....  . . | .||| ...   |..||||.. |.       .   |||||.|   ...  || || ||..||.|||.||.  ... .. .
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd......egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

Y_phosphatase Protein-tyrosine phosphatase 255-406 1.4e-17 59.3 Pfam-A 85-232 (235) alignment
Range on Protein: 255-406
Range on HMM: 85-232/235.0
QSFFPLSTDHYLNLEGWLINTRavevdQRCKNWMNK---YTVEVVADGCS-EA-TFaKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptVGKQPPVIV
. ..| ... .|. .   ....     .. |.....   ...|.  .. . |  .. |.. .|.|| .. |...|..| |.|.  |..     |. ||.|
aqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvV

MCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
.|  |  |..|.|. .|..||. .....|  .. ...| ||.|...    . . ..|
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka

Y_phosphatase Protein-tyrosine phosphatase 255-406 1.4e-17 59.3 In-house 85-232 (235) alignment
Range on Protein: 255-406
Range on HMM: 85-232/235.0
QSFFPLSTDHYLNLEGWLINTRavevdQRCKNWMNK---YTVEVVADGCS-EA-TFaKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptVGKQPPVIV
. ..| ... .|. .   ....     .. |.....   ...|.  .. . |  .. |.. .|.|| .. |...|..| |.|.  |..     |. ||.|
aqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvV

MCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
.|  |  |..|.|. .|..||. .....|  .. ...| ||.|...    . . ..|
hCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflyka

0043147 (Phosphotyrosine protein) phosphatases II 147-402 1.6e-17 59.2 In-house 3-152 (172) alignment
Range on Protein: 147-402
Range on HMM: 3-152/172.0
DVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPikdeaieefanfpapaspvpppptasskdigsspdqqprereqieiks
. . |||||.. .    ...| ||.||..|. |||.|..  ..| .... |                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

ircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevVADGCSEATFAKVYNCTTWPWKSYPdDVKKVLALVRAPVKESspTVGKQPP
                                                 . |.  .  .   | .. ||  . | . . .| ...   .     . .. |
.................................................lydpellerlgiqylylpwpDhgvp.llellleflefidell..alspggp

VIVMCDLGLDRSATVVLTSIIIeqvldgKTPDCDDLFRKMRDQRAGVFTMSIFFTY
|.| |  |..|..|.|.  ...      .  . .. .. .|..| |...   .  .
vlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrf

subfamily_Ptp69D_pd Subfamily Ptp69D 95-196 1.7e-17 58.5 In-house 28-123 (307) alignment
Range on Protein: 95-196
Range on HMM: 28-123/307.0
FDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPekskmgPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
..   |. .. .... | . |  ||| .|.|  | |||.|..       . ..   |||||.|.  . . ..|  | |. .|| |||.|.   .|| .. 
yekLeareidkstkvsekkenalknRyedikafDktRvkLkki......ngkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

IF
. 
ls

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 86-195 4.1e-17 57.1 In-house 6-106 (285) alignment
Range on Protein: 86-195
Range on HMM: 6-106/285.0
MKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDdvegYINASHIRFDN-ASTDYILTQYPLPSTIRDFWKMV
||  ...  .. ..  | | .||.  .| | . ||  ||. |. ||||| | ..      |    || || .|.     . || || ||| |. |||.|.
mkcqaisklhqdkikgymppnctytayeanpdlnryadvrcieetrvvlknhdr......d....yihaswmrmpgkdqstyittqgplpetlsdfwhmi

YVTKVTQVITI
|  |.. |. .
yqekiayvlml

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 105-391 4.7e-17 56.5 In-house 35-216 (392) alignment
Range on Protein: 105-391
Range on HMM: 35-216/392.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEpIKDEAi
.. |  . | |..||| |..  .|..||.|   . .   | .|   |.|||.|.  ..   || .| | .... |||.||.  .|| .. . . .|.   
ypqtvaqkeinlkknryknilpydsarvkleviddi...pdsd...ylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtk.lkegd.

eefanfpapaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvaDGCSEAT
                                                                                              | .  |
.............................................................................................kgddart

FAKvYNCTTWPWKSYPDDVKKVLALvrapVKESSPTVGKQP-PVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRA
 |. .  | || |  |  .  .| .    .|| .   |.   |.|. |  |. |.. |.    .. .    .  |  ..  ..| .| 
vaq.fhftewPdkdvpkhtssllkf....ikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp

subfamily_PTPRG_pd Subfamily PTPRG 102-211 5.8e-17 56.1 In-house 34-138 (563) alignment
Range on Protein: 102-211
Range on HMM: 34-138/563.0
YSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKD
 .  .... . ..| .|||. ..  .| .|| |..         ..   ||||..|   . | ..| ||.||..|. |||.|..  .|. ...| .  ..
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgk.....kkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlver

EAIEEFANFP
.. ...  .|
grrkcdvYWP

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 110-204 6e-17 56.7 In-house 36-124 (281) alignment
Range on Protein: 110-204
Range on HMM: 36-124/281.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmgpaddVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAI
 . ..||.||| ...   |||||..|. |..|         ||||...   .  ..|| || |.|... .||.||. .||.... . . |. . .
skadenvlknrYsnivaYDatrvkvtpneenk......ntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagkl

0051429 (Phosphotyrosine protein) phosphatases II 148-413 1.3e-16 56.5 In-house 3-227 (272) alignment
Range on Protein: 148-413
Range on HMM: 3-227/272.0
VEGYINASHIRFDnasT------DYILTQYPLPSTIRDFWKMvYVTKVTQVITIFEPIKDEAIEEFANFPapaspvpppptasskdigsspdqqprereq
..|||||...      .       ......||| |..|||.. .  ... .... ..   ..   .   |                              
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywp..............................

ieiksircdnHLHQSFFPLSTDHYLNLEGWLINTRAVEVDqRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYP-DDVKKVLALVRApvkesspt
          ...  ..|.  |..   . . .  . ...   . ...  . . .   . .||    .. .| ||  ..| . ....|.|...        
..........girylhlpilddsaptilygalrvtllsee.llldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld........

vgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPD--------CDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKL
   . ||.| |  | ||..|||.  .....| .    |         ..  ...|.||.|..    .. .  .|.| .|. 
...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs

subfamily_PTPN1_pd Subfamily PTPN1 105-211 1.7e-16 54.8 In-house 22-118 (290) alignment
Range on Protein: 105-211
Range on HMM: 22-118/290.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaddveGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAI
 ...  . ..| |.|| .||.  | .|..| . ..           ||||| . ...|   ||||| |||.|.  ||.||.  |   |. . . .  | |
fptreaklpenrnlnryrdvspydhsrikleradn..........dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

EEFANFP
  .  .|
kcaqywP

0049772 (Phosphotyrosine protein) phosphatases II 107-412 1.7e-16 56.3 In-house 38-281 (314) alignment
Range on Protein: 107-412
Range on HMM: 38-281/314.0
CTFNEWEKNVNKNRTKDVKLIDaTRVVLTnpekskMGPADDvEGYINASHIRFDnasTDYILTQYPLPSTIRDF----------WKMV--YVTKVTQ---
...   ..| .|||..|.   | .||.|         | ..  .|||||...      ..| ||.||. |. ||          |.||  .  .|     
ilvadlflnrdknryldilpad.nrvilp......glpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

----------------------------VitifepikdeaieefanfpapaspvpppptasskdigsspdQQPREREQI--Eiksircdnhlhqsffpls
                                                                       .| ....   .                  
srdevladelsrLdaAlgKtpllildgng.........................................neptaadlellk..................

tdhylnlegwlintravE-----------------------------VdqrcknwmnkytvevvadgcseatfakvyncttwpwksypddVKKVLALVRA
                 |                                                                        ....|.....
.................eelydpelferlgikylripvpDgsaplled..........................................fdeflefiee

PvKessptvgKQPPVIVMCDLGLDRSAT-VVLTSIIIEQvldgKTpDCDDLFRKMRDQRA-----GVFTMSIFFTYAIRAALFYLK
  .       |. ||.| |  | .|..| ||.  ... .    .  . .. .. .| .|      | . . . . .  .| | |||
a.d.......kggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk

subfamily_PTPN23_pd Subfamily PTPN23 113-198 2.6e-16 54.3 In-house 41-117 (288) alignment
Range on Protein: 113-198
Range on HMM: 41-117/288.0
EKNVNKNRTKDVKLIDATRVVLTnpekskmGPADDvegYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEP
.....||| .|.   | .||.|        |  ||   |||||...     . |.| || ||.||. |||.|||  |.  .. . ..
klyseknrsrdilPyDhnRvklr.......gskDD...YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllsk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 109-197 4.1e-16 53.9 In-house 41-123 (288) alignment
Range on Protein: 109-197
Range on HMM: 41-123/288.0
FNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
  .  .| .||| ...  .| .|| |.. |.       . . |||||.|  .. .  || || ||..|. |||..|| .|.. .. . |
agrlavnakknRyrnilpyDekrvklkklee......eagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmlte

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 78-196 8.1e-16 53.0 In-house 8-121 (305) alignment
Range on Protein: 78-196
Range on HMM: 8-121/305.0
GLCKYILDMKEASLNTY-FDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmgpaddVEGYINASHIRFDNASTDYILTQYPLPST
 | .|| ...  | ...  . ..    ....  .. |.|..|||.|.. | |  |. ||. |. .       . |||||..   . .  ||..| ||..|
dlaayikearvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekesld......dsdyinasyvdgykrkkkyivaqgPlknt

IRDFWKMVYVTKVTQVITIF
..|||.... .||.... . 
vadfWrliveekvstivmlt

subfamily_PTPN14_pd Subfamily PTPN14 88-207 1.2e-15 52.4 In-house 22-136 (300) alignment
Range on Protein: 88-207
Range on HMM: 22-136/300.0
EASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpEKskmgpaDDVEGYINASHIRFDNAS--TDYILTQYPLPSTIRDFWKMVY
|. . | ..    .   ....  . ..|..|||.|||   . .|| |.   |      .. .||||||.|.   ..   .|| .| ||. |..|||.||.
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsp.tk......enstgyinassikvsvggkersyivaqgPleltvqdfWqmvW

VTKVTQVITIFEPIKDEAIEEF
 ..|. .. . | ..|     |
eqgvqlivmlteeeedgkeksf

subfamily_PTPN9_pd Subfamily PTPN9 80-194 1.3e-15 52.2 In-house 7-115 (297) alignment
Range on Protein: 80-194
Range on HMM: 7-115/297.0
CKYILDMKEASLNTYFDANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRD
 .|. ....  |   . .  ..    . .  .   |..||| .||  .| |||||.. ..      |.   ||||...   .    .| || ||. |..|
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvde......deasdyinanfvdGykqkkafiatqGplkktvsd

FWKMVYVTKVTQVIT
||.||.  .|  .. 
fWrmvWeqevlvivm

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 109-216 2.2e-15 51.2 In-house 30-132 (287) alignment
Range on Protein: 109-216
Range on HMM: 30-132/287.0
FNEW--EKNVNKNRTKDVKLIDATRVVLTNpeKSKMGPAddvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEE
| .     .|.|||  ||  || |||.|..  ....| .     |||| ..   .    .| .| |...|.||||..|. |... |||.   ...   . 
fkaaeelaavkknryadvlPiddtrvllsa..egelGsd.....yinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

FANFPAPASP
.  .| .  |
ykywPerevP

subfamily_PTPN13_pd Subfamily PTPN13 105-195 3.4e-15 51.0 In-house 27-108 (273) alignment
Range on Protein: 105-195
Range on HMM: 27-108/273.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaddvegYINASHIRF--DNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
 .|.  . ..| .||| ..|  .|.||| | .              |||||.|.   ..   .||..| ||| |..|||.||.  |.. .. .
dtcevgkkkenkdknryrnvlPydetrvklgdegg...........yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 113-193 8.6e-15 49.6 In-house 7-81 (250) alignment
Range on Protein: 113-193
Range on HMM: 7-81/250.0
EKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
 .| .|||  |.  .| .|||| . .      .|.   |||||..   . .  .| || ||..|| |||.||.  |.. ..
pqnkeknryadiialdssrvvLekek......gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtiv

0036282 (Phosphotyrosine protein) phosphatases II 150-402 9e-15 50.3 In-house 3-161 (174) alignment
Range on Protein: 150-402
Range on HMM: 3-161/174.0
GYINASHIRFDNASTDYILTQYPLPstirdFWKMVYVTKVTQVITIFEPIKDEAIEEFANFPApaspvpppptasskdigsspdqqprereqieiksirc
 |||||.. .   .. .|..|.||.     ||.|..  ..| |..  |.. ..    .  .|                                      
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.....................................

dnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvaDGCSEATFAKVYNCTTWPWKSYPDDVKkVLALVRAPVKESSPtvGKQPPVIV
                                                .  ..  .   | .. ||  . ||. . .| .|..  .  |   ... ||.|
................................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlV

MCDLGLDRSATVVLTSIIIEQVLdGKTPDCDDLFRKMRDQRAGVFTMSIFFTY
 |  |..|..|.|.  ... . |  .. |  ||.|..| || |....  .. .
HCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf

subfamily_PTPN3_pd Subfamily PTPN3 104-195 9.9e-15 49.2 In-house 30-115 (280) alignment
Range on Protein: 104-195
Range on HMM: 30-115/280.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADdvegYINASHIRFDNAS----TDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
  ...     .|..||| .|.   ||||| |.. |      .|    ||||... ..  |    . || || ||..|  |||.||.  |.. .. .
glaisaarkpenlsknryrdilpydatrvklkese......td....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 112-195 1.8e-14 48.6 In-house 43-120 (318) alignment
Range on Protein: 112-195
Range on HMM: 43-120/318.0
WEKNVNKNRTKDVKLIDATRVVLTNPEKSKMgpADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
 . | .|||  ..   | ||| |.. |...   .|    ||||..|   ...  || .| ||| ||.|||.||.  . . ....
epvnkaknryanilaydhtrvkLqmlegeeg..sD....yinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivml

subfamily_PTPRK_pd Subfamily PTPRK 112-197 2.4e-14 47.9 In-house 40-119 (314) alignment
Range on Protein: 112-197
Range on HMM: 40-119/314.0
WEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
 ..| .|||..|.   | .||.|.  .       |    ||||. |   . .. .| ||.||..|..|||..||  . . .. . |
kdenreknrsgdilaydrsrvflitid......gdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmlte

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 93-195 3.5e-14 47.6 In-house 23-122 (319) alignment
Range on Protein: 93-195
Range on HMM: 23-122/319.0
TYFDAN---LANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKmGpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKV
|... .   | . .. . .  . |.| .||| .... .| |||||.. . .. |       |||||.|   .  . .| || ||  || |||.||.  ..
tllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgve.g.....sdyinasfidgyqerekfiatqaPlentiedfWrmvWeees

TQVITI
  |. .
sivvml

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 103-202 3.5e-14 47.4 In-house 34-129 (290) alignment
Range on Protein: 103-202
Range on HMM: 34-129/290.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpeksKMGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDE
|. . | .  ..| ..|| ... . |  |..| .    . |  |  . ||||..|   . . .||.|| |...|..||||...  ||| .. . . |...
sehtvtvgltssnkllnRfanivvyddnritLrp....isghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieeg





subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 104-193 4.8e-14 47.0 In-house 9-93 (270) alignment
Range on Protein: 104-193
Range on HMM: 9-93/270.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpE---KskmgpaDDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
.|. .. |. .. . || .|.    ||||.|   |   .      |..  |||| ..| ||.... || .. |||.|...||.|.. .||| ..
tsesdlpeaargkklnRyadiLPsPatRvrl...eelee......dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaiv

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 81-203 7.5e-14 46.4 In-house 8-121 (307) alignment
Range on Protein: 81-203
Range on HMM: 8-121/307.0
KYILDMKEASLNTYFDaNLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPekskmGPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDF
.  ||.   .|   |  .||...|   | . .. | .||| .||| .| .|.|.. .     | | |   || | ..        .| .| || .|. .|
qrtldkgvqalvdefr.vlakktpegvtveafsantdknryqdvkcqdkgrivvkfd.....glasd...yihanylgiaikpkkficaqgplentqysf

WKMVYVTKVTQVITIFEPIKDEA
| |.   ||  || . . |.   
wamaiqekvesvimlckvielak

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 97-197 1.1e-13 45.6 In-house 22-118 (301) alignment
Range on Protein: 97-197
Range on HMM: 22-118/301.0
ANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSKMgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
 .| .... .|| .  |.| . || |... .|  |..|.. .. ..      . |||||.|   . .. .| .| |. .|..|||....  |....... 
kelkegedksctvglseenkalnrfknitvyddnriilkpkpnldl....cqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

E
.
n

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 109-202 2e-13 44.9 In-house 27-112 (283) alignment
Range on Protein: 109-202
Range on HMM: 27-112/283.0
FNEWEKNVNKNRTKDVKLIDATRVVLTNPEKskmgpaddveGYINASHIR---FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITiFEPIKDE
 .  ..| .||| ...   |  || | .  .           ||||..|     .. . .|| .| ||  |..||||||.  |.| ..  . .....
iasadenkrknrnqeivpadqwrvelksesr..........dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivm.ltklqed

subfamily_PTPRN_pd Subfamily PTPRN 99-206 2.1e-13 44.6 In-house 38-141 (297) alignment
Range on Protein: 99-206
Range on HMM: 38-141/297.0
LANYSP--SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpADDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|..|    | ..  . ||||.|||.|.|   | .|| |..        ... . ||||| |   |  .. || || ||.||. |||.||.   |. ....
lcayeaepstkevakaeknvkknrskavlpydhsrvklkeea......saeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnl

FePIKDEAIEE
  ....| ...
t.rleeegvkq

0049260 (Phosphotyrosine protein) phosphatases II 162-400 2.6e-13 45.4 In-house 7-139 (152) alignment
Range on Protein: 162-400
Range on HMM: 7-139/152.0
ASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEEFANFpapaspvpppptasskdigsspdqqprereqieiksircdnhlhqsffpls
 .. .| ||.|.| |. |||.|..  ..| .... |.  .  . .   .                                                   
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...................................................

tdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfakVYNCTTWPWKSYPDDVKKVLALVRAPVKEsspTVGKQPPVIVMCDLGLDRSATV
                                               | .. ||  . ||.   .| |...  |       |. ||.| |  |..|..|.
..............................................qylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtl

VLTSIIIeqvldgKTPDCDDLFRKMRDQRAGVFTMSIFF
|.  ...      .  . .. .. .| .| |...   . 
vaaylml......lgvsleeavalvrekRpgavpnpgql

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 102-196 2.7e-13 44.6 In-house 34-118 (287) alignment
Range on Protein: 102-196
Range on HMM: 34-118/287.0
YSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTnpekskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
 .. . | |  ..| .||| ...   |  ||.|           .  . ||||..|   . .  .|... |. .|.|.|||..   .|| .. . 
qredevthniasqnkdknRltqilvpdnyrvllk..........gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlc

0046846 (Phosphotyrosine protein) phosphatases II 151-411 4e-13 45.0 In-house 14-173 (176) alignment
Range on Protein: 151-411
Range on HMM: 14-173/176.0
YINASHIRFDnastDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKDEAIEEFAN--------Fpapaspvpppptasskdigsspdqqprereqi
||||. |  .     .| ||.|||.|. ||..|..  ..| |... |..  . .  .          .                                
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................................

eiksircdnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfakVYNCTTWPWKSYPDDvKKVLALVRAPVKESSPTvg
                                                                  | .. ||  . ||. . .| |...  .  .    
.................................................................qylhlpwpDhgvpdl.elllellefirealkeg..

kqPPVIVMCDLGLDRSATVVLTSIIIEqvldGKTPDCDDLFRKMRDQRA-GVFTMSIFFTYAIRAALFYL
   ||.| |  |. |..|.|.  ...     .|  . .. ....|.||  |...   .  .  ...|..|
..gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefellll

subfamily_PTPN6_pd Subfamily PTPN6 113-192 7.9e-13 43.1 In-house 52-126 (306) alignment
Range on Protein: 113-192
Range on HMM: 52-126/306.0
EKNVNKNRTKDVKLIDATRVVLTnpEKSKMGpaddvEGYINASHIR--FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQV
 .| .||| | .   | |||.|.  |.| .|     . ||||. |.  . . .. || ||  |..|. |||.||.  . . .
penkeknryknilPfDhtrvilk..epsvpg.....sdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 100-196 1.3e-12 42.3 In-house 29-119 (315) alignment
Range on Protein: 100-196
Range on HMM: 29-119/315.0
ANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
 .  ... .    . | .||| |..  .| .||.|   ..|   | .|   |||||.|.  .    || .| ||.... |||.||. .||| .. . 
pdPdiyrqrvaretinfkknryknilPldsarvklevidds...Pdsd...yinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

subfamily_egg_pd Subfamily egg 96-408 2e-12 41.4 In-house 23-267 (307) alignment
Range on Protein: 96-408
Range on HMM: 23-267/307.0
DANLANYSPSKCTFNEweKNVNKNRTKDVKLIDATRVVLTNPEKSKMGpaddveGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVtQVITI
  ....  . . ....   | .| |.| |.  | .|| |  ..   ..       .| | ... .    ..||.| ||  |  |||.||.  .| | | .
leesvdeislttaasd..nnlekarskrvhckdssrvklelrrGqyld......dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeev.qyivm

FEPIKDEaieefanfpapaspvpppptasskdigsspdqqprereqieiksircdNHLhQSFFPLSTDHYLNLEGWLINTRAVEVDQRCKNWMNKYTVEV
..  |.                                                 ..  . ..| . .. | .    ..  ...||..    ..   . .
ltsrkes................................................erc.eyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl

VADGcSEATFAKVYNcttWPWKsYPDDVKKVLALVRAPVKESSptvgkqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGktPDCDDL----FRKMRDQRA
|     |  | . ..   . .. .  ||   | ..|   . |        ||.| . ||  ..||.|   | . ..| |  |    |       .| .| 
vGgd.deerflehwq...gdvn.nssdvysplrvlrklrnlsk.......pvvvqdilGvskaatlvaieiallsllrG..pitkslvlravvflrlrrr

GVFTMSIFFTYAIRAAL
      . . .  |  |
lsvesvllylfvyrlvl

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 108-197 2.9e-12 40.5 In-house 36-119 (515) alignment
Range on Protein: 108-197
Range on HMM: 36-119/515.0
TFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
|  . | | .||| |..  .| .|| |   . .   |  |   |.|||.|.  ..   || .| |..... |||..|.  .|| .. . .
tvaqeeinfkknryknilPydsvrvklevindn...Phsd...yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtk

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 113-197 4.2e-12 40.8 In-house 46-126 (325) alignment
Range on Protein: 113-197
Range on HMM: 46-126/325.0
EKNVNKNRTKDVKLIDATRVVLTNpekSKMGPADDvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVY--VTKVTQVITIFE
 .|..||| |.|  .| .||||      |  |  |   |||||..| |     .. .| ||..|| |.|..|.   . |  |. ...
penkaknrfknvvaldksrvvlet...kkddpssd...yinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneld

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 106-195 4.3e-12 41.1 In-house 16-99 (284) alignment
Range on Protein: 106-195
Range on HMM: 16-99/284.0
KCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpeKSKMGpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
. || . ..| .|||  ..   | ..| |    .  .|   .   |||||.|        || || ||. |. |||.|..  ... .. .
dqtfanldqnkdknrighilafdknvvkl....erliG..eefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 105-195 4.5e-12 40.9 In-house 51-135 (319) alignment
Range on Protein: 105-195
Range on HMM: 51-135/319.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLtnpeKSKMGpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
.. || . ..| .|||  ..   | ..| |    .   |   .   |||||..        || .| ||. |. |||.|..  ... .. .
adqtfanldqnkdknriinilafdknvvkl....erliG..eefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivll

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 96-196 6.6e-12 39.6 In-house 28-115 (303) alignment
Range on Protein: 96-196
Range on HMM: 28-115/303.0
DANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmgpaddvEGYINASHIRFDnASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
  ....| | . . |.. ||..|||  ||  .| ..| |..              || ||.. .| .|   |||| ||. |  |||.|.   ||  |. .
fekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd............ssyihasyleld.sskkailtqlplshtaadfwqmiieqkvkcvlll

F
.
l

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 104-194 6.7e-12 39.6 In-house 41-124 (310) alignment
Range on Protein: 104-194
Range on HMM: 41-124/310.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpEKSKMgpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVIT
 |  |.. ..|.. |||  ||   |..|| |.  .||.       | || | ... .   . .| .| ||  || |||.|..  .   .. 
dssltyeaykkymhknrysdvvcldtsrvklki.dksry......edyihanyvktnylrstficsqgplqhtiidfwrmifqeraesill

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 83-207 7.9e-12 39.2 In-house 20-137 (302) alignment
Range on Protein: 83-207
Range on HMM: 20-137/302.0
ILDMKEASLNTYFdANLANY--SPSKCtfNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmgpaddvEGYINASHIRFDNASTDYILTQYPLPSTI---
.  ...|.... |  ....   .  ||  . . ||..||...||...|...| |.. .          . |.|||..   . .   ||.| |  ..    
vksldtaevkkef.kkidtmkvdlekC..kafkknlkknqsedvpildsnlvkleaep..........dsyvnaskvevPeltrsiilaQlpkvdsedsv

RDFWKMVYVTKVTQVITIFEPIKD-EAIEEF
 .||.||.  |...|  .  . .  ....|.
eeFWrmvfqekivsvvilvgeeelkktlsel

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 288-393 9.8e-12 39.5 In-house 156-262 (318) alignment
Range on Protein: 288-393
Range on HMM: 156-262/318.0
MNKYT---VEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFR
...|.   ..|  ....|    . |..|.|| .. |... ..|.|||  |..   . |.. |..| |  |  |  . .  .|..|.. . .. |  .  .
lsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrq.vskaqqksgag.pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvk

KMRDQRAGV
..|.||  .
qlreqrnlm

0044763 (Phosphotyrosine protein) phosphatases II 150-398 1.1e-11 40.2 In-house 19-158 (178) alignment
Range on Protein: 150-398
Range on HMM: 19-158/178.0
GYINASHIRfDNastdYILTQYPLpstiRDFWKMVYVTKVTQVITIFEPIKDEAIEEFANFPAPASpvpppptasskdigsspdqqprereqieiksirc
 |||||.|  ..    ..|...|      |......  ..| .... |..    ..... .|  |.                                  
dyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..................................

dnhlhqsffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfaKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvGKQPPVIV
                                                           | .. .|  . ||  . .|..|..  .  .    |. ||.|
.........................................................iqylhipipDhgvpdllehflefvefieeald...ekggpvlV

MCDLGLDRSATVVLTSIIIEQvldgkTPDCDDLFRKMRDQRAgVFTMSI
 |  |..||.|.|.  .....       . .. .. .| .|  ...   
HCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

subfamily_PTPRA_pd Subfamily PTPRA 104-195 1.2e-11 39.1 In-house 47-132 (330) alignment
Range on Protein: 104-195
Range on HMM: 47-132/330.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpadDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
 . .   . |.| .|||  ..   | .||.|.. |        .   |||||.|   .    .| .| |.  |. |||.|..  | . .. .
qatlelaskeenkeknrvvnilPydfsrvilsvkeGv......eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativml

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 114-199 1.3e-11 39.0 In-house 48-127 (315) alignment
Range on Protein: 114-199
Range on HMM: 48-127/315.0
KNVNKNRTKDVKLIDATRVVLTNPEKskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
.|..|||  ..   | .|| |   |.      |.   |.||. |   |    || .| |......|||..|.  ...... . . .
enkqknryiniiaydksrvqlpllen......dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlv

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 99-202 1.9e-11 38.1 In-house 37-132 (290) alignment
Range on Protein: 99-202
Range on HMM: 37-132/290.0
LANYSPSKCT-FNEWEKNV--NKNRTKDVKLIDATRVVLTNpekskMGPADdvegYINASHIRFDNAstDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|  | |..    . ..||   .||| |||   | |||.| .      .. |    |. | ...  .|   .|||| .| .|. |.|.||  .||. .. .
lkpylpvqylerkifdkntefkknrykdvvcndktrvilkd.....GydGd....yvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivml

FEPIKDE
 | |.| 
celiedG

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 115-195 2e-11 38.3 In-house 47-135 (350) alignment
Range on Protein: 115-195
Range on HMM: 47-135/350.0
NVNKNRTKDVKLIDATRVVLTNPEKSKMGPAD--DVEGYINASHIRFD------NASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
   ||| |..   . .|| | .  ||  .       . ||||....        |..  || || |||||. ||.|...  ||. ....
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

subfamily_CG7180_pd Subfamily CG7180 104-196 2.6e-11 37.7 In-house 31-117 (296) alignment
Range on Protein: 104-196
Range on HMM: 31-117/296.0
PSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkskmGPADDVegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
  .|  .  ..| .|||  .|   | .||||.. .    | ...   ||||...       .|| |. |  .|. .||..||  ..  |. . 
igdCagglrkenreknrdvkvvPyDynRvvLekld....Geeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLt

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 304-410 4.4e-11 37.4 In-house 137-241 (250) alignment
Range on Protein: 304-410
Range on HMM: 137-241/250.0
TFAKVYNCTTWPWKSYPDDVKKVLALVRaPVKESSPTVGKQpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYA
   . .. ..|| |. |.  . ||.|..  |. | . .|.. |||| |  |  || . .  . ..|..   |. |  .. ...| .| .. .    . . 
rivrqlhfvvWPdkgvPevatavLellk.kvqasqqqagna.PvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfv

IRAALFY
 ...| .
yeiilka

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 302-411 1.1e-10 36.2 In-house 183-290 (298) alignment
Range on Protein: 302-411
Range on HMM: 183-290/298.0
EATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKEsSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFT
.    .  . |.|| |. |   . ||.|.|  |.  |..  .. |||| |  | .|| | .  . ..|.|   .. |  .  . .| .|.|. .    ..
kerevrqlhftsWpdkgvpenatsvldllrk.vra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYv

YAIRAALFYL
.   | | .|
fiyeavleal

0051082 (Phosphotyrosine protein) phosphatases II 148-402 1.4e-10 36.4 In-house 2-144 (151) alignment
Range on Protein: 148-402
Range on HMM: 2-144/151.0
VEGYINASHIRFDnastdYILTQYPLPstirDFWKMVYVTKVTQVITIFEPIKDE---AIEEFANfpapaspvpppptasskdigsspdqqprereqiei
...|||.| .        ......||.    ||.....  ... .... ..   .    . . ..                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

ksircdnhlhQ-------------SffplstdhylnlegwlintravevdqrcknwmnkytvevvadgcseatfakvyncttwpWKSYPDDVKKVLALVR
                        .                                                              ..| |...| |..
..........ievlhipildwpdpg...........................................................lplsfdavleflelll

ApvkessptvGKQPPVIVMCDLGLDRSATVVLTSIIIEQvldgktPDCDDLFRKMRDQRAGVFTMSIFFTY
.          |. ||.| |  |..|..|.|.  .....       . .. .. .| .| ||.. .  | .
d.........kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 98-197 1.6e-10 35.1 In-house 19-114 (281) alignment
Range on Protein: 98-197
Range on HMM: 19-114/281.0
NLANYSPSK-CTFNEWEKNVNKNRTKDVKLIDATRVVLtnpeKSKMgPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
||    ||  ||  .   | .|||  ..  .| .|| |    | || |  .   || | .||       ||||| |   |  |||.|..  . | .. . 
nlpgdppsdlctvfnqpvnnkknrylnipcldisrvql....kvkm.pnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

E
.
q

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 108-195 2.1e-10 35.2 In-house 44-123 (297) alignment
Range on Protein: 108-195
Range on HMM: 44-123/297.0
TFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgPADDvegYINASHIRFDNAstDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|  |   | .|.| |..  .|  || |   ...   |  |   |.|||...  .    .| || | ..|. |||.||.  .|. .. .
tvaekkvnfeksRYkniLPydssRvkLaivndd...pdsD...yvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 114-196 2.4e-10 35.0 In-house 2-77 (237) alignment
Range on Protein: 114-196
Range on HMM: 2-77/237.0
KNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaddvEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIF
.|  |||  ...  | .||||  .  .          ||||.... || .   || .| || |.  |||.||.  | . .. . 
enkiknrygnivaydhsrvvlkgagsg........sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmlt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 105-207 3.3e-10 34.4 In-house 23-114 (267) alignment
Range on Protein: 105-207
Range on HMM: 23-114/267.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEKSkmgpaddvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTqVITIFEPIKDEAI
|...    ||| ..||  |.   | |||.| . |.           |||||..   .    .|.|| ||  || ||....   ||. || .  ..  . |
stisqsiaeknqernrlddnlpyddtrvilrtkeee..........yinasyvegyktknafivtqdplkntitdfltvihdqkvp.vivlltkvftdni

EEF
  |
rlf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 96-194 4.7e-10 33.8 In-house 14-106 (297) alignment
Range on Protein: 96-194
Range on HMM: 14-106/297.0
DANLANYSPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmGPAD-DvegYINASHIRFDNAST--DYILTQYPLPSTIRDFWKMVYVTKVTQV
|. | .  . . .    .  . ||| .|.   | ||| | .      .... |   |||| .. | .  .   |||.| || .|. |||..|.   |  .
dllldeargesfssakrnsslrknryrdilatddtrvkllr......viterd...yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvi

IT
. 
vm

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 277-437 1e-09 32.6 In-house 149-299 (312) alignment
Range on Protein: 277-437
Range on HMM: 149-299/312.0
AVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKEssptvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT
 .|.  . |. . .  . ||     . .  . |. ..|| .  || .   | |. |  |.       . |||  |  |. |. |..|   .|  .   . 
eieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkd.......kkpviahcsagvgrtgtlaliesmiaalrhprk

PDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKlqCLNeNGNEDVKTMITEALAKV
 .  | |  .| .||    .   . ||.|. | .|  |   |  . ||.  | . |. ||.
qnvkdsfvllrkdrarsvrvfpqyvyalrcvleflysk..gly.krneqewtkfketyaki

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 116-195 1.1e-09 32.1 In-house 49-138 (349) alignment
Range on Protein: 116-195
Range on HMM: 49-138/349.0
VNKNRTKDVKLIDATRVVLTNPEKSKMGP--------ADDVEGYINASHIRFDNASTD--YILTQYPLPSTIRDFWKMVYVTKVTQVITI
  ||| ||.   . .||.| .  ||  .         .  .. |||| .... . |..  || || |||||. ||.|..   .|  |. .
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

subfamily_PTPRD_pd Subfamily PTPRD 296-393 1.2e-09 32.4 In-house 169-263 (564) alignment
Range on Protein: 296-393
Range on HMM: 169-263/564.0
VADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGV
     ||.   . .. | || .  |.  ...|.|.|  |.....   .. |..| |  |  |. | .  ....|.. . || |     ...| ||  .
kkkkssesreVrqFhFtsWPdhgvpesatslLdlirk.vralne..pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnam

subfamily_ptpA1_pd Subfamily ptpA1 103-193 1.3e-09 32.3 In-house 35-118 (418) alignment
Range on Protein: 103-193
Range on HMM: 35-118/418.0
SPSKCTFNEWEKNVNKNRTKDVKLIDATRVVLTNPEkSKMGpaddvEGYINASHIRFdNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
 ||. .  . ..| .|||  ..  .. ||| | . .  | |       |||| .|       ..| || ||| || |||.||.  ..  ..
gpsetsegdkkhntsknrytnilpvnhtrvqlkkiq.dkeg.....sdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriiv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 106-196 1.4e-09 31.9 In-house 89-168 (244) alignment
Range on Protein: 106-196
Range on HMM: 89-168/244.0
KCTFNewEKNVNKNRTKDVKLIDATRVVLTnpeKSKMGpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTqVITIF
| .||   .|  |||      .|  || |.   |. ||     . ||||| .     ...|||||.||  |  |||||.   .|  |. ..
kdafn..pnnswknregaglpfdfnrvpls...kgsmg.....ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvn.vlvvl

subfamily_PTPN12_pd Subfamily PTPN12 278-420 1.4e-09 32.3 In-house 142-286 (290) alignment
Range on Protein: 278-420
Range on HMM: 142-286/290.0
VEVDQRCKNWMN-KYTVEVVADGC-SEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK
.||..  .....  ...  ..  . .|    . .. | || .  |  .|..|.|... |.|      .. |..| |  |  |  |..   .. |.. ..|
fevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssakslleliel.vrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaek

TPDCDDLF---RKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLNE
.|.. |.|   ...| ||| .      ...  .| . ... .|. ..|
ipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee

subfamily_PTPN6_pd Subfamily PTPN6 308-416 2.4e-09 31.6 In-house 190-302 (306) alignment
Range on Protein: 308-416
Range on HMM: 190-302/306.0
VYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVG--KQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT---PDCDDLFRKMRDQRAGVFTMSIFFTY
 |. ..|| .. | | . ||....  |.. . ..   .. |..| |  |. |  |.... |.....   ..    |  .| ...|.|| |.  .   . .
qyhfksWPdhgvpkdpgavLdfled.vnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykf

AIRAALFYLKLKLQ
  .|  .|.. | .
vykaikkyietkkk

subfamily_PTPN13_pd Subfamily PTPN13 286-412 2.7e-09 31.7 In-house 148-270 (273) alignment
Range on Protein: 286-412
Range on HMM: 148-270/273.0
NWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
. ..  ...|     .|.      | ..||  . |   ...| .|.  |..      .. |..| |  |. || |..   .... .   |  |  .. ||
dgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvae.vrrlqt...dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrk

MRDQRAGVFTMSIFFTYAIRAALFYLK
.|.|| ||   .  . .  .|.|  ||
lreqrqgvvqtkdqyifvykailevlk

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 105-199 3.4e-09 31.2 In-house 33-117 (288) alignment
Range on Protein: 105-199
Range on HMM: 33-117/288.0
SKCTFNEWEKNVNKNRTKDVKLIDATRVVLTnpekskmgpaDDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
|. . ... .|  ..| ...   |.||| |.          || . ||.|  .   .     | .| || .||  .|||. .. |  .. . | .
sidiidsfianptrdryenlprcditrvkls..........ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcell

subfamily_PTPN3_pd Subfamily PTPN3 311-397 4.9e-09 30.5 In-house 178-261 (280) alignment
Range on Protein: 311-397
Range on HMM: 178-261/280.0
CTTWPWKSYPDDVKKVLALVRApVKESSptVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMS
 . || .. ||| ...| .|.  |..     ||. ||.| |  |..|.  ..|  . .  .   .     |. |.|||||| .   .
ylaWpdhgvPddsadflefver.vrklr..sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqta

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 108-197 5.6e-09 30.1 In-house 42-121 (305) alignment
Range on Protein: 108-197
Range on HMM: 42-121/305.0
TFNEwEKNVNKNRTKDVKLIDATRVVLTNPEkskmgPADdvegYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFE
.| |  .. .||| |||  .|  || | .|      | .    || | ..     .  .| || ||  |  ||| | .  || ... . .
afke.aqeagknrykdvgcldnnrvklegpw.....phe....yihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcn

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 107-195 5.7e-09 29.9 In-house 38-122 (439) alignment
Range on Protein: 107-195
Range on HMM: 38-122/439.0
C--TFNEWEKNVNKNRTKDVKLIDATRVVLTNpekskmGPADDVEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITI
|  ..   | .  ||| |||   | |||.| .       |      |||| .|.       || ||.|   |  |||..|.  |.......
ciaslaaqeydqtknrykdvgafdhtrvtlqe......ipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 254-400 7.4e-09 30.1 In-house 94-229 (239) alignment
Range on Protein: 254-400
Range on HMM: 94-229/239.0
HQsFFPLSTDHYLNLEGWLINTRaVEVDQrcknWMNKYTVEVVadGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQpPVIVMCDL
|| ..| || .| ||   | .|  |  |      .  . .  |  | .|  .   |  | || |  |.    || | |   |.| |  | . | .. |  
hq.ywpdstskycnlrvtlrkte.vfady....iirtfvmsqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp..gar.pwvihcsa

GLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFF
|. |. ....   .. |    || |  .  . .|..|  .   |  .
gvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqy

subfamily_Ptp69D_pd Subfamily Ptp69D 308-410 7.5e-09 30.1 In-house 186-285 (307) alignment
Range on Protein: 308-410
Range on HMM: 186-285/307.0
VYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTvgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAA
 |. |.|.    |.  . .| |..   .  .     . |..| | .| .||...|  .....|.   .. |  .  ...| ||  ...    ...  || 
qyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral

LFY
| |
ldy

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 254-399 8.1e-09 30.0 In-house 95-229 (239) alignment
Range on Protein: 254-399
Range on HMM: 95-229/239.0
HQsFFPLSTDHYLNLEGWLINTRaVEVDQrcknWMNKYTVEVVadGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQpPVIVMCDL
|| ..| || .| ||   | .|  |  |      .  . .  |  | .|  .   |  | || |  |.    || | |   |.| |  | . | .. |  
hq.ywpdstskycnlrvtlrkte.vfady....iirtfvmsqv..gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslp..gar.pwvihcsa

GLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIF
|. |. ....   .. |    || |  .  . .|..|  .   |  
gvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseq

subfamily_PTPN14_pd Subfamily PTPN14 311-396 8.6e-09 29.8 In-house 190-281 (300) alignment
Range on Protein: 311-396
Range on HMM: 190-281/300.0
CTTWPWKSYPDDVKKVLAL------VRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTM
 | || .  |.|||. |        ||  .......  ..|||.| |  |  |.  ..|. ..|. .  ... | .  ....| ||  .   
ytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt

subfamily_eak_pd Subfamily eak 115-207 1e-08 29.0 In-house 52-135 (332) alignment
Range on Protein: 115-207
Range on HMM: 52-135/332.0
NVNKNrTKDVKLIDATRVVLTNPEKSKmgpaddvEGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIKdEAIEEF
.||.|   ..   |   | ||.  . .       .|||||| . | .    ||||  .  . .  ||.||.  |   .. . | .. . .|..
avnrn.vvkivpydrylvrltssqlnr.......lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledve.lkleks

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 258-414 1.1e-08 29.4 In-house 110-267 (270) alignment
Range on Protein: 258-414
Range on HMM: 110-267/270.0
FPLSTDHYLNLEGWLINTRAVEVDQRckNWMNKYTVEVVADGCSEATFakVYNCTTWPWKSYPDDVK------KVLALVRApVKESSPTVGKQPPVIVMC
.| .... ..||   |...|..  ..  .   .  ...  .| ..      .  .||| .. | .        ..|...|| |..|.    |. |..| |
Wpaepkekvkledgkikvlalseeke..egyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlra.vrrsekeldkaePllvHc

DLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLK
  |..|. |.... |... .   |  |.  . ...| .|  .   .  .... .| . | . .
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 259-406 1.8e-08 28.4 In-house 141-278 (290) alignment
Range on Protein: 259-406
Range on HMM: 141-278/290.0
PLSTDHYLNLEGWLINTrAVEVDQRCKNWMNKYTVEVVADGCSeaTFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESsptvGkqpPVIVMCDLGLDRS
|    . | .  . .   . | |.  .  ..  .|  . .| .     | ..  .|| || .     .| ..|.  | |    |   ||.| |  |. |.
pekeGevltfGeitvlc.seeddkdaniikktlsvrdkdsGke..hklkhlkikswpdksvalstlallrtlrilrkas....G...pvvvhcsaGiGrt

ATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
 | |   . .. .||||  |  || | .|. |..   . | .   ...
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalvei

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 292-406 1.9e-08 28.4 In-house 174-282 (305) alignment
Range on Protein: 292-406
Range on HMM: 174-282/305.0
TVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRapvkESSPTVGkqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT-PDCDDLFRKMRDQR
|| |.    ..|  .. |    || .  |     .| |.     .. |. |   |..| |  |. |. .||.   |..|.| |.   |.| ...|.|.||
tvlviegpgekarkvthyhwidwpdrgvpaadlailelle....karpskg...pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqr

AGVFTMSIFFTYAIRA
         . .  . 
nnsiqtdaqylfvhqv

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 284-402 2.9e-08 28.1 In-house 154-270 (288) alignment
Range on Protein: 284-402
Range on HMM: 154-270/288.0
CKNWMNKYTVEVVADG--CSEATfAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVgkQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDD
 .. ....... .  .   .| .  . |. ..|| .. |.. . .|.|.|  || ...    . |.|| |  |. |. | .    .|..|   .. |  .
eskeledfvlrklllekkktele.itqyqylaWpdhgvPeskapllellrq.vkvanqad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvag

LFRKMRDQRAGVFTMSIFFTY
   |.| ||| .      . .
tvaklRkqRallvqtlkqYef

subfamily_CG42327_pd Subfamily CG42327 120-209 5e-08 27.0 In-house 33-116 (319) alignment
Range on Protein: 120-209
Range on HMM: 33-116/319.0
RTKDVKLIDATRVVLtnpeksKMGPADDVEGYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPIkDEAIEEFAN
|  .|  .  |||||      .  . || . |..||..| .|.| . || .| .| ..  |||..|.  .   .... ..  .  |.  |.
rvinvvPlPetrvvl......qrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls.elGikvcae

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 334-412 5.4e-08 26.8 In-house 211-290 (305) alignment
Range on Protein: 334-412
Range on HMM: 211-290/305.0
VKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK-TPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLK
..  |   | . |..| |  |. |. |.|    |.|.. . |  |   .| . .|||||      . . .  |  | |. 
lellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 301-415 6.3e-08 27.0 In-house 168-275 (288) alignment
Range on Protein: 301-415
Range on HMM: 168-275/288.0
SEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPvkessptVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFF
 |. . |.     |. .. |.. .  | |.             | |..|..  |  |..|..|. |..|..          |. |.|..|    .    .
eekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqy

TYAIRAALFYLKLKL
 |. |  | .| || 
lyvhrcvleelllkk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 255-434 8.1e-08 26.7 In-house 114-283 (290) alignment
Range on Protein: 255-434
Range on HMM: 114-283/290.0
QSFFPLSTDHYLNLEGWLINTRAVEVDQRcknwMNKYTVEVVADGCSEATFAKvYNCTTWPWKSYPDDVKKVLALVRApVKEssptvgKQPPVIVMCDLG
. ..| | .  |...|  ..    | ..     ... ...|  |.  | |.   .    |   . ..| | .|.|..  ||       .. |||| |  |
akYvpesvgeelkfkgltvkCkskekedd....vetRelvvkfddeeeftvtH.sllkgWnklnvqedtktllsliqk.vka......sktpvivHcvdG

LDRSATVVLTSIIIEQVL-DGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAALFYLKLKLQCLNENGNE-DVKTMITEAL
. |||..    .    .    .     |.  ..| ||| ..|  . ..... .......  |.   |. .|  .|.  .|..
iSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeekety

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 289-411 9.8e-08 26.3 In-house 163-277 (307) alignment
Range on Protein: 289-411
Range on HMM: 163-277/307.0
NKYTVEVVADGCSEAtfAKVYNCTTWPWKSYPDDVKKVLALVRApvkesspTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKT-PDCDDLFRKMR
|  |..|.  . | .   . .. . || .  |.     . |. |       . ... ||.| |  |. || |.|  |.. .....|.   | ..| ...|
nvttlkvdwaqksrt..iqhlqwenwpdrgvpqinltainllea.......vrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelr

DQRAGVFTMSIFFTYAIRAALFYL
.||       . . |  |  | |.
sqrhyaiqteaqylylhrvlleyf

subfamily_PTPRK_pd Subfamily PTPRK 273-394 1.3e-07 25.7 In-house 142-260 (314) alignment
Range on Protein: 273-394
Range on HMM: 142-260/314.0
INTRAVEVDQRCKNWMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVL
|.   ||..  ..  .  ..|| .| | .|    . .. ..||    |   . .|.|||  ||.|..   .. ...| |  |  |. | .  .|... . 
ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr.vkksqee..eaGrivvhCsaGaGrtGtfiaidivldmie

DGKTPDCDDLFRKMRDQRAGVF
  .. |     ...|...  . 
regvvdvfnavktlrsrkvnmv

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 297-395 1.3e-07 26.1 In-house 171-267 (305) alignment
Range on Protein: 297-395
Range on HMM: 171-267/305.0
ADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPtvGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFT
.|. .|      |. |.|| .  |.    .| |..   |. .   .|. |..| |  |. |. . .  .| .|..   .. |  .. ...| .| .. .
ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvq

subfamily_PTPN23_pd Subfamily PTPN23 284-404 1.4e-07 25.7 In-house 152-273 (288) alignment
Range on Protein: 284-404
Range on HMM: 152-273/288.0
CKNWMnKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVK-ESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGK-TPDCDD
 .... ......   . ..    .  . |.||    |.  ...|... .  .  ..     . |..| |  | .|. .. |   .....  |.  .|  .
tethv.ervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiq

LFRKMRDQRAGVFTMSIFFTYAI
.....| ||  .   .  .  . 
vvsrlreqRrfmvqekeqlkfsy

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 307-404 1.4e-07 25.9 In-house 181-279 (319) alignment
Range on Protein: 307-404
Range on HMM: 181-279/319.0
KVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSI---FFTYA
| .  | || .  |.. . .|.|..  ...|     .. |..| |  |  |  | .  ....|.|    . |     ...| ||  .        |  .|
khfqyteWpdhdvPekatslldllkr.irksrekt.qsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyea

I
.
l

0048076 (Phosphotyrosine protein) phosphatases II 306-405 1.6e-07 26.7 In-house 47-137 (145) alignment
Range on Protein: 306-405
Range on HMM: 47-137/145.0
AKVYNCTTWPWKSYPDDVKKVLALVRAPVK---EssptvgkQPPVIVMCDLGLDRSATVVLTSIIIEqvldgKTPDCDDLFRKMRDQRAGVFTMSIFFTY
   | .. ||  . ||. . .|.....  .   |         ||.| |  |..|..|.|.  ....     .  . .. ....| || |...   .. .
giqylylpwpDhgvpdllellleflefieealke.......ggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrf

AIR
 ..
lye

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 289-415 1.7e-07 25.6 In-house 156-280 (281) alignment
Range on Protein: 289-415
Range on HMM: 156-280/281.0
NKYTVEVVADGCSEATFAKVyNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKqPPVIVMCDLGLDRSATVVLTSIIIEQVLDG-KTPDCDDLFRKMR
 . .... .... . . ... . |.|| .  |.. |..|   .. |.. . .  |  |... |  |  |. | .    ....| .  .. | ... ...|
ierkfkleresgetreveql.aytaWPdhGvPattkellefrke.vlkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelr

DQRAGVFTMSIFFTYAIRAALFYLKLKL
 .|  .    . ...  .| | .|. .|
kernlmvqtvvqyefvykavldaldkel

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 270-432 2.1e-07 23.9 In-house 175-330 (346) alignment
Range on Protein: 270-432
Range on HMM: 175-330/346.0
GWLINTRAVEVDQRCKnwmnKYTVEVVADGCSEATFAKVYNCTTWPWKSYPddvKKVLALVRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIE
  .|| |  .|    |    .||.||. .| |..  ..|.  . |     |    | | ...   .  |    ..  | |.  .|  |. . . .   |.
kmfinnrradvsgdpk....eytievlpegnsdsvicqvhhhapwkhlqqp...pktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyain

QVLDGKTPDCDDLFRKMRDQRAGVFTmsIFFTY-AIRAALF-YLKLKLQCLNENGNEDVKTMITE
|. .|  |.  ........|| |      |  | .| | .| |.  |    ..  | |.. .| |
qlnngiepniceimknikqqrpggve..sfaqyasiyaivfdyiarkrggkkapvnkdinrfide

subfamily_PTPRG_pd Subfamily PTPRG 300-402 3e-07 24.0 In-house 179-278 (563) alignment
Range on Protein: 300-402
Range on HMM: 179-278/563.0
CSEATFAKVYNCTTWPWKSYPDDVKKVLALVRAPVKESSPTVGkqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIF
| .    . |..|.|| .. |.    ||  |.   .    ..|   |..| |. |  |. | .  . ...|. . .. .  .. ...| ||  ...    
cdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaG...PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEq

FTY
...
Yif

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 113-199 4.6e-07 23.8 In-house 53-131 (305) alignment
Range on Protein: 113-199
Range on HMM: 53-131/305.0
EKNVNKNRTKDVKLIDATRVVLTNPEkskmgPADdvegYINASHIRFDN-ASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEPI
. .. ||| .||   | . | | .|      |.|    || | ..         .| .| ||  || .|| ||   || |.. .   .
diaitknryqdvpcqdqsavkldkps.....psd....yihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktv

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 115-193 5.3e-07 24.1 In-house 8-81 (239) alignment
Range on Protein: 115-193
Range on HMM: 8-81/239.0
NVNKNRTKDVKLIDATRVVLtnpEKSKMGPADDvegYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
|  |||  ..   | .||||   ||    |  |   |||||..| .| .   || ||  .  .  |||.|..  .   ..
nkaknryanivtydhsrvvl...eklsndphsd...yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv

subfamily_PTPRA_pd Subfamily PTPRA 288-410 5.5e-07 23.8 In-house 173-294 (330) alignment
Range on Protein: 288-410
Range on HMM: 173-294/330.0
MNKYTVEVVADGCSEA--TFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKqpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRK
. |. |. ..|.. |      . .  |.||    | . . .| |... ||.  .  .   |..| |  |  |. | .  . ..|.|   .  |  .  ..
vrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkk.vkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkr

MRDQRAGVFTMSIFFTYAIRAALFY
.| ||. .      ...  .. | |
lrlqrpqmvqtdeqyefiykvlley

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 115-193 5.6e-07 23.9 In-house 7-80 (239) alignment
Range on Protein: 115-193
Range on HMM: 7-80/239.0
NVNKNRTKDVKLIDATRVVLtnpEKSKMGPADDvegYINASHIR-FDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVI
|  |||  ..   | .||||   ||    |  |   |||||..| .| .   || ||  .  .  |||.|..  .   ..
nkaknryanivtydhsrvvl...eklsndphsd...yinasylrdydgspkayiatqgcveissgdfwrmmwqerrcviv

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 251-395 5.8e-07 23.5 In-house 129-266 (301) alignment
Range on Protein: 251-395
Range on HMM: 129-266/301.0
NHLHQSFFPLSTDHYLNLEGWLINTRAVEvdQRCKNWMNKYTVEVVAD-GCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESsptvgkQPPVIV
.. .....|... . |... . |...  |  .  .. ..| |.||.   |  ..     |. ..|. .  |    ..  |.   ||.|      . |..|
eekceeylpvkisekldigrfkikiknke..lilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmel.vkks......ekPivv

MCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRA-GVFT
 |  |. || . . | ..  .|.  .| .  . ....|..|  || |
hcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqt

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 287-404 6.9e-07 23.5 In-house 150-265 (285) alignment
Range on Protein: 287-404
Range on HMM: 150-265/285.0
WMNKYTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPtvgKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKM
 .|  ||    | .||  . .  .   || .  |.| . .. | .  ||.  |   |. |. | |  |. |.||.|       ....    .  |. |.|
ilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykw.vkkvnp...kekpicvhcsagvgrtatfvgidyatirimenpniemldivrem

RDQRAGVF--TMSIFFTYAI
|  |       | ..| | .
ramrfqavqshmqflflyvv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 290-396 7.2e-07 23.6 In-house 163-269 (297) alignment
Range on Protein: 290-396
Range on HMM: 163-269/297.0
KYTVEVVADGCSEATFAKVYNCTTWPWKSYPD--DVKKVLALVrAPVKESSPTVGKQpPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMR
| ..||  .      . | |. . || |. .   .....| |.   |...  .. .  |..| |  |. | . ..    .. .. . |. |  .| .|.|
krelevtkgkakarrvvkqyqfveWPdkaverkdsassllkli.sevrkdfsqnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklr

DQRAGVFTM
..|  .   
qerpylvqt

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 343-408 8.3e-07 23.1 In-house 227-292 (297) alignment
Range on Protein: 343-408
Range on HMM: 227-292/297.0
KQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRAAL
.. ...| |  |. ||  |||. .|....  .. ||   . ...|.||| .      |..   |.|
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 308-404 1.5e-06 21.9 In-house 178-272 (439) alignment
Range on Protein: 308-404
Range on HMM: 178-272/439.0
VYNCTTWPWKSYPDDVKKVLALVRApvKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIFFTYAI
 .  ..|| |  | .   || ..||   .|.    .  ||.| |  |. |. |..   | .||.   .  | . . . .|.||  .      . .  
qfhyiawpdknvpaqashvldflra..insandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiy

subfamily_PTPN9_pd Subfamily PTPN9 310-408 1.5e-06 22.5 In-house 179-287 (297) alignment
Range on Protein: 310-408
Range on HMM: 179-287/297.0
NCTTWPWKSYPDDVKKVLA---LVR-------APVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRAGVFTMSIF
  ..||    |.. ...|     ||         . ...    ..||..| |  |. |. | .   | .... .  | |  .  ...| |||    .   
qflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeq

FTYAIRAAL
...   | |
yefcylavl

0048179 (Phosphotyrosine protein) phosphatases II 307-400 1.6e-06 23.4 In-house 50-134 (144) alignment
Range on Protein: 307-400
Range on HMM: 50-134/144.0
KVYNCTTWPWKSYPDDVKKVLALVRAPVKESSptvgKQPPVIVMCDLGLDRSATVVLTSIIIeqvlD-GktPDCDDLFRKMRDQRAGVFTMSIFF
  | .. ||  . ||. . .|.....  .  .    .  ||.| |  |..|..|.|.  ...      |   . .. .. .| .| |...   ..
iqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk....klg..lsleealalvrsrrpgavpnpgql

subfamily_PTPN1_pd Subfamily PTPN1 257-395 1.7e-06 22.0 In-house 116-255 (290) alignment
Range on Protein: 257-395
Range on HMM: 116-255/290.0
FFPLSTD-HYLNLEGWLINTRAVEVDQRCKNWMNkyTVEVVADGCSEATFAKVYNCTTWPWKSYPDDVKKVLALVRApVKESSPTVGKQPPVIVMCDLGL
..|   . . | ||   .. . .. ... .  ..  ..|.    . |.     .  ||||  . |.   . | ..   |.||   . .. |... |  |.
ywPqgeeekellledtklkvkliseerksyytvr..llelenlktqetreilhfhyttwpdfgvpespaaflkflfk.vresGslssdvGpavihcsaGi

DRSATVVLTSIIIEQVLDGK---TPDCDDLFRKMRDQRAGVFT
 || |..|   .. .. . .   . |  . . ..| .| |.  
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliq

subfamily_PTPRN_pd Subfamily PTPRN 310-406 1.8e-06 21.9 In-house 193-287 (297) alignment
Range on Protein: 310-406
Range on HMM: 193-287/297.0
NCTTWPWKSYPDDVKKVLALVRaPVKESspTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDG-KTPDCDDLFRKMRDQRAGVFTMSIFFTYAIRA
   .|| .. |   | .| . |  |  |    |.  |..| |  |  |. . .|  ......| | |  |      ..||||.|.      | .|. |
hflswpeegvPasaksllefrr.kvnks..yrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 302-391 2.5e-06 21.9 In-house 131-219 (237) alignment
Range on Protein: 302-391
Range on HMM: 131-219/237.0
EATFAKVYNCTTWPWKSYPDDVKKVLALvRAPVKESSPTVGKQPPVIVMCDLGLDRSATVVLTSIIIEQVLDGKTPDCDDLFRKMRDQRA
|  . . |. |.|| .  |.    .| . |  . . || | .  | |. |  |. |.. ...   .. |  . |  |  .    . ..| 
evrlihqyqftswpdrgvpqqtaallrf.rkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrp

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 149-197 2.7e-06 21.7 In-house 13-60 (130) alignment
Range on Protein: 149-197
Range on HMM: 13-60/130.0
EGYINASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVtQVITIFE
. ||||| .   . ...|.||| ||  |  |||||.    |  |. .. 
ntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryv.nvlvvlg

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 110-197 3.5e-06 21.4 In-house 13-100 (290) alignment
Range on Protein: 110-197
Range on HMM: 13-100/290.0
NEWEKNVNKNRTKDVKLIDATRVVLTNPEKsKMgpaddVEGYINASHIRFDNAsTDYILTQYPL-------PSTIRDFWKMVYVTKVTQVITIFE
 .. |. ....  .| |. |||||| .  | ..     ...|| |... . |     |||| |.        ||| .|| |.   ||.||. . |
tdyvkkhemdqRlevpLveatrvvLkgygk.rf.....nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlce

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 152-198 6.5e-06 20.1 In-house 78-124 (301) alignment
Range on Protein: 152-198
Range on HMM: 78-124/301.0
INASHIRFDNASTDYILTQYPLPSTIRDFWKMVYVTKVTQVITIFEP
| |  |  .  .  .| || ||..|  ||| |.   .| ... . . 
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqk