Gene M05D6.3 in Caenorhabditis elegans

Synonym: CELE_M05D6.3, CELE_M05D6.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf12
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP127_AA protein Get Run
CeleP127_AA_55-359 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 57-388 6.1e-246 808.8 In-house 1-332 (332) alignment 
Range on Protein: 57-388
Range on HMM: 1-332/332.0
EAFKAVTVEGPELLNQMHTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEYIFWRMVSERK
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
eafkavtvegpellnqmhtsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserk

PSMILVFGDIDEKQKRKAPYDISDRGFEKSFLHEFGAKSLEECELKAKICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHF
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
psmilvfgdidekqkrkapydisdrgfeksflhefgaksleecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvlmhf

YEWADASKLPEYMLDMRASIKLQYIRSSKKTGVCIGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
yewadasklpeymldmrasiklqyirsskktgvcigpimlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmk

FAVTTGVVHDAAIGEKPKPQKSIVGKGPKSGF
||||||||||||||||||||||||||||||||
favttgvvhdaaigekpkpqksivgkgpksgf
DSPc_SM00195 76-357 8e-57 187.9 In-house 12-261 (263) alignment 
Range on Protein: 76-357
Range on HMM: 12-261/263.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKqkrk
|. . . |  .. .|...||  . ...||.||.| ....  ..|..||....|..||..||..|.|. ..|   |||||.|.| ..|... . .|.    
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeen....

apydisdrgfeksflhefgaksleecelKAKICRKFWPEK-RSKKDFPTLSIQASDDHS---ETHMKTFNLTVTEKKQDHQTVLMHFYEWADAsKLP---
                            . . | ..|||.  .|..| ..|..  . ..   |....|..|| ..|......  ... .| |  ..|   
............................gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdst

EYMLDMRASIKLQYIRSskktgvcIGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
...|..  ..| .. .|        |||. .| .||..... .|||||.|...||..| ..|.......||.|...|   |....|.....
ksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 76-357 8e-57 187.9 In-house 12-261 (263) alignment 
Range on Protein: 76-357
Range on HMM: 12-261/263.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKqkrk
|. . . |  .. .|...||  . ...||.||.| ....  ..|..||....|..||..||..|.|. ..|   |||||.|.| ..|... . .|.    
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeen....

apydisdrgfeksflhefgaksleecelKAKICRKFWPEK-RSKKDFPTLSIQASDDHS---ETHMKTFNLTVTEKKQDHQTVLMHFYEWADAsKLP---
                            . . | ..|||.  .|..| ..|..  . ..   |....|..|| ..|......  ... .| |  ..|   
............................gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdh.gvpdst

EYMLDMRASIKLQYIRSskktgvcIGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
...|..  ..| .. .|        |||. .| .||..... .|||||.|...||..| ..|.......||.|...|   |....|.....
ksvlellravkksksts.......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
0036941 (Phosphotyrosine protein) phosphatases II 79-362 5.9e-47 155.8 In-house 28-281 (297) alignment 
Range on Protein: 79-362
Range on HMM: 28-281/297.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKapydi
 .. .. ....|...|| .. ...||.|| |  .|...|..|||.||||. | ..| .|.| .. | . ||||| | . ..|... . .|... |     
lgslsvallpenleknRykdilpydhtRVkl..ddegsdYinAsyvdgydlkrkfIatqgPlpn.tvedFWrmvweqnvtvIvmltelvelgrek.....

sdrgfeksflhefgaksleecelkakiCRKFWPEK-RSKKDFPTLSIQASDDHS--ETHMKTFNLTVTE--KKQDHQTVLMHFYEWADASKL--PEYMLD
                           | ..||.. .. . .  ....  . ..  ........|.||   ... ..   .|.  | | .    |...||
...........................caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslld

MRASIKLQYiRSSK-KtgvciGPIMLVCATGVEKCAISATIDIIVSRIT---EEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVTTG
.   .. .. . .  .     ||..  |  || ...  ...|......    .|..| ..|..  ...||.|.. |.. |   .|.|...  .. 
fielvrkvl.kllpsg.....gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0040438 (Phosphotyrosine protein) phosphatases II 78-387 7.4e-45 149.0 In-house 31-304 (317) alignment 
Range on Protein: 78-387
Range on HMM: 31-304/317.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKap
  .. .. ....|.|.||.|. ...||||| | | .|   .|..|||.|||...| ..| .|.|  ..| . ||||| | . ..|. . . .|....|  
kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.pntvedFwrmvweqgvtvivmLteleelgrek..

ydisdrgfeksflhefgaksleecelkakiCRKFWPEkRSKKDFPTLSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWADASKL--PEYMLD
                              | ..||. .... . .....  . . . ... ..|.|.  .... ..   .|.  | | .    |. .||
..............................caqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

MRASIKLQYirsS--KktgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAvTTGVVHDAAI
.   .. ..   .  .      ||..  |  || ...  .......... .|..| ..|..  ...|| |.. | . |   ...|...  .....   | 
fleavreal...edpg......gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl.krkltlepas

GEKPKPQKSIVGKGPKSG
  | |..|  . . ... 
elklkllklliplalddv
0047943 (Phosphotyrosine protein) phosphatases II 79-356 6.3e-44 145.9 In-house 27-270 (273) alignment 
Range on Protein: 79-356
Range on HMM: 27-270/273.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKapydi
 .. .. .. .|.|.||.......||||| |  .||..|..|||.|||| .| ..| .|.| .. | . ||||| | . ..| .  ...|....|     
lltysvallpenkdknrykdilpydhsrvkl..gdggsdyinAsyvdgynlkrkfiatqgPlpn.tvedfwrmvweqnvrviVmLtelvelgrek.....

sdrgfeksflhefgaksleecelkakiCRKFWPEKRS--KKDFPTLSIQASDDHSETHMKTFNLTVTE--KKQDHQTVLMHFYEWADASKL--PEYMLDM
                           | ..||..    .. .  ...   . ... ......|..|    .. ..   .|...| | .    .|..|..
...........................caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllef

RASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
   .. ..  . ..     ||..  |  || . .  ...|...... .|..| ..|..  ...||.|.. |.  |   .|.|..
ielvrkalealpsn.....gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 74-361 3.2e-43 143.5 In-house 12-277 (284) alignment 
Range on Protein: 74-361
Range on HMM: 12-277/284.0
HTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWVDGY-----SKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGD
 |  .... .. ....|...|| ......||||| | . ||.   .|..|||.||||      .| ..| .|.| .. | . ||||| | . ..| .. .
ltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn.tvedFwrmvweqnvrvIVmlte

IDEKQKRKapydisdrgfeksflhefgaksleecelkakiCRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTE---KKQDHQTVLMHFYEWADA
..|... |                                | ..||.. ... .  ...   . . . ......|..|    ... ..   .|. .| | 
lvengrek................................caqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdh

SKL--PEYMLDMRASIKLQYIRsskktGVCIGPIMLVCATGVEKCAISATIDIIVSRITEEH---RVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
.    || .|..   .. .. .       . |||.  |  || . .  ...|.. ... .|.   .| . |... ...||.|.. |.  |   .|.|. .
gvppspedlleflrlvrellen.....lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealley

AVTT
. ..
lklk
0051299 (Phosphotyrosine protein) phosphatases II 78-357 3.3e-43 143.6 In-house 37-285 (288) alignment 
Range on Protein: 78-357
Range on HMM: 37-285/288.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKap
.... .. .. .|.. || ......||||| | . ||   .|..|||..||| .| ..| .|.| .. | . ||||| | . ..| .. ...|....|  
pdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn.tvedFWrmvweqnvrvIvmltklvelgrek..

ydisdrgfeksflhefgaksleecelkakiCRKFWPEkRSKKDFPTLSIQASDDHSETHMKTFNLTVT------EKKQDHQTVLMHFYEWADASKL--PE
                              | ..||. .... .  ...   . ... ......|.||       ... ..   .|.. | | .    ||
..............................caqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

YMLDMRASIKLQYIrsskktgVCIGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
 .||.   .. ..         . ||..  |  || ...  ...|...... .|..| . |..  ...||.|.. |.  |   .|.|. .
llldflrlvrkala.......sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0050432 (Phosphotyrosine protein) phosphatases II 79-358 1e-42 141.9 In-house 57-299 (308) alignment 
Range on Protein: 79-358
Range on HMM: 57-299/308.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELapqDGKDDFYNASWVDGY--SKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKapy
 .. .. .. .|.|.|| .. ...||||| |   |...|..|||.||||   .. ..| .|.| .. | . ||||| | . ..| .. ...|... |   
lleysvallpenkdkNrykdilpydhsRVkl...degsdYInAsyvdgyssklprkfIatqgPlpn.tvedFwrmvweqnvrvIvmLtklvengrek...

disdrgfeksflhefgaksleecelkakiCRKFWPEK--RSKKDFPTLSIQASDDHSETHMKTFNLTVTE--KKQDHQTVLMHFYEWADASKLP--EYML
                             | ..||..  .. . .  ...   . ... ......|..|   ... ..   .|.  | | .  |  | .|
.............................caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

DMRASIKLQYirsSKktgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
|.   .. ..   ..      |||.  |  || ...  ...|...... .|..| . |..  ...|| |.. |.  |   ...|....
dflelvrksl...pg......gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0043336 (Phosphotyrosine protein) phosphatases II 56-355 4.2e-41 136.6 In-house 15-274 (278) alignment 
Range on Protein: 56-355
Range on HMM: 15-274/278.0
EEAFKAVTVEGPELLNQMHTsamtYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPfNDHTEYIFWRMVS
  ..|... .. | |.....    .. .. ....|.|.||... ...||||| | . .|   .|..|||.||||... ..| .|.| ...|.. ||||| 
llnlktllllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgP.lpetvedFwrmvw

ERKPSMILVFGDIDEKQKRKapydisdrgfeksflhefgaksleecelkakiCRKFWPekRSKKDFPTLSIQASDDHSETHMKTFNLTVT--EKKQDHQT
| . ..|..  . .|... |                                | ..||  .. . . ....   . ... ......|.||   ... .. 
elgvttivmLtelvelgrvk................................caqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtv

VLMHFYEWADASKL--PEYMLDMRASIKLQYIrsS-KktgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYS
. .|.. | | .    .. .||.   .. ..   . .      ||..  |  || ...  ..........  |..| . |... ...||.|.. |   | 
thyhylgwpdhgvpeslsllldflkavreale..dsn......gpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyr

TACEMLM
  .|.|.
flyeall
0039614 (Phosphotyrosine protein) phosphatases II 76-357 5.7e-41 136.3 In-house 42-288 (297) alignment 
Range on Protein: 76-357
Range on HMM: 42-288/297.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWVDGYSK-KSAYIFAQAPfNDHTEYIFWRMVSERKPSMILVFGDIDEKQk
  .. . .. .. .|.|.||... ...||||| | | ||    .|..|||.||||.. . ..| .|.| ...| . ||||| | . ..|.   . .|.. 
lslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgP.lpetvedFwrmvweqgvtvivmLtklvelg.

rkapydisdrgfeksflhefgaksleecelkaKICRKFWPEKRSkkDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKL--PEYM
                                . | ..|||. .   . ....   . . . ......|.|| ... ..   .... | | .    .|..
................................rkcaqywpeegg..tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslell

LDMRASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|..   .. .. ...|.     ||.   |  || ...  .......... .|..| ..|... ...|| |.. | . |   ...|...
leflelvrealaelpkg.....gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0045450 (Phosphotyrosine protein) phosphatases II 71-356 5.9e-41 136.6 In-house 37-302 (307) alignment 
Range on Protein: 71-356
Range on HMM: 37-302/307.0
NQMHTSAmTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWV--------DGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSM
.....    .. .. ....|.|.||... ...||.|| | . ||.   .|..|||.|        ||| .| ..| .|.| .. | . ||||. | . ..
lsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.tvedFwrmlweqgvtv

ILVFGDIDEkqkrkapydisdrgfeksflhefgaksleeceLKAKICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVT---EKKQDHQTVLMHF
|.   . .|                                |. ..| ..||...... .  . .   . . . ... ..|.||   .... ..   .|.
ivmltelve................................lgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhy

YEWADASKL--PEYMLDMRASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHR---VGFKETMSAIKMQRFGCFRTVGPYSTAC
..| | .    .| .||.   ..  . ...|.     ||..  |  ||  ..  ...... ... .|.    | . |... ...|| |.. . . |   .
tgwpdhgvppsfeelldfieevrkaleelpkg.....gpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

EMLMK
|.|..
ealle
0040439 (Phosphotyrosine protein) phosphatases II 81-356 1.7e-39 131.3 In-house 2-244 (249) alignment 
Range on Protein: 81-356
Range on HMM: 2-244/249.0
PNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPfNDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKapydi
. .. ....|.|.||.|. ...||||| | . .|   .|..|||..|||  | ..| .|.|  ..| . ||||. | . ..|. . . .|... |     
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgP.lpetvedfwrmlwelgitvivmLtslvelgrek.....

sdrgfeksflhefgaksleecelkakiCRKFWPEkRSKKDFPTLSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWAdASKLPEYMLDMRASI
                           | ..||. .. . . .....  . ... ......|..|  .......   .... |    ..|... |. . |
...........................caqywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfi

KLQYIRSSKK-TGvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
..     ..  .|   ||..  |  || .... .......... .|..| ..|... ...||.|.. . . |   .|.|..
eavrkaleelpkg...gpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0042113 (Phosphotyrosine protein) phosphatases II 84-355 3.3e-38 126.9 In-house 3-240 (245) alignment 
Range on Protein: 84-355
Range on HMM: 3-240/245.0
YDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKapydisdr
. ....|.|.||... ...||.|| | | .|   .|..|||.||||  .  .| .|.| .. |   ||||. | . ..|. . . .|... |        
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrvk........

gfeksflhefgaksleecelkakiCRKFWPEkRSKKDFPTLSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWADASKL--PEYMLDMRASIK
                        | ..||. .... . .....  . ... ......|.||   ... .. . .|.. | | .    .|..||.   ..
........................caqywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr

LQYIRSSKktgvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
 .. ..|.      ||..  |  ||  ..  .......... .|..| . |..  ...|| |.. | . |    |.|.
kalaedsn......gpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 82-342 2.3e-28 94.4 In-house 53-275 (319) alignment 
Range on Protein: 82-342
Range on HMM: 53-275/319.0
NTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGdidekqkrkapydis
 |.    .| | ||| ..  ||...| | . .|..  |. |||.|.|| .|  || || |  | |   ||||. | . | |...                
qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl.dntladfWrmiweyncstivllt...............

drgfeksflhefgaksleecelkAKICRKFWPEKRSK-KDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQT-VLMHFYEWADASkLPEYMLDMRASIK
                        . | ..|| |  . ..   ..... .. .|  .. ..|.   |..| .     ||  | |    |.|  |.   .|
.......................kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvG.vpdypsdlmrlvk

L-QYIrSSKKTGVciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFR
  ...  ||. .    .|.. |..|| .  .  ..|....|. ||..|   ...  .. ||    .
kvrhl.tskenhr..anivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvq
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 83-344 3.6e-28 93.9 In-house 18-241 (284) alignment 
Range on Protein: 83-344
Range on HMM: 18-241/284.0
TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGdidekqkrkapydisd
|.    .| | ||| |.  ||...| | . .|..  |. |||.. || .|  || .| |  | |   ||||. | . | |...                 
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPl.dntladfWrmiweyncstivllt................

rgfeksflhefgaksleecelkAKICRKFWPEKRSK-KDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQT-VLMHFYEWADASkLPEYMLDMRASIKL
                       . | ..|| |  . ..   ..... .. .|  .. ..|.   |..| ..   .||  | |    |.|  |. . .| 
......................kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvg.vpdypsdlmrlvkk

QYIRSSKKTGVciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTV
    .||. .    .|.. |..|| .  .  ..|....|. ||..|   ...  .. ||    . .
vrhltskenhr..anivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdl
0045098 (Phosphotyrosine protein) phosphatases II 81-355 6.9e-27 90.0 In-house 24-269 (278) alignment 
Range on Protein: 81-355
Range on HMM: 24-269/278.0
PNTYDKFLNNMDMNRIPHLYCFDHSRVElapqdgkdDFYNASWVDGYskKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQkrkapydisd
  |.  .|.|.|.||... ...|||||         |. |||..|||  . ..| .|.|.. .|   ||||. | . . |.   .  |..          
eitpalylgnldknRykdilpydhsrVk........dYINAsyidgy..pkkfIatqgPlp.stvadfwrmlwelgitvivmltelvelg..........

rgfeksflhefgaksleecelkAKICRKFWPEkRSKKDFPTLSIQASDDHSETHMKTFNLTVT------EKKQDHQTVLMHFYEWADASKLPEY----ML
                       . | ..||| .. . .  ...   . .   .. .  |.||      |  . .    .|.. | | .  ..     .|
......................rekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfl

DMRASIKLQYIRSSKK---------TGvciGPIMLVCATGVEKCAISATIDIIVSRIteEHRVGFKETMSAIKMQRFG-CFRTVGPYSTACEMLM
..   |.  . .  ..          |   ||.   |  ||   .  . .... ...  |..| . |. . ...|| | .. . . |   .|.|.
ellefirealkllaslllsslllldsg...gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefll
0037934 (Phosphotyrosine protein) phosphatases II 86-355 2.7e-24 81.5 In-house 6-239 (243) alignment 
Range on Protein: 86-355
Range on HMM: 6-239/243.0
KFLNNMDMNRIPHLYCFDHSRVELapqDGkDDFYNASWVDGYSKksaYIFAQAPFNDhTEYI----FWRMVSERKPSMILVFGDIDEKQKRkapydisdr
....|.. || .. ...||||| |   .| .|..||...... .   .|  |.| .. |       ||||. | . ..|. . . .|...          
llpenlsknrysdilpydhsrvkl...eg.sdyinanliyvtpr...liatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgre.........

gfeksflhefgaksleecelkakICRKFWPekrS-KkDFPTLSIQASDDHSETHMKTFNLTVTE---KKQDHQTVLMHFYEWADASKLP-EYMLDMRASI
                        | ..||   . .  . .....  . ..  ... ..|...    ... .. .  |.. | | .  .    |    ..
.......................kcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldflde

KLQYIRS-----SKKTGvciGPIMLVCATGVEKCAISATIDIIVSRIteehRVGFKETMSAIKMQRFG-CFRTVGPYSTACEMLM
  ..|..       ..|   ||. . |  || . .  ...... ...    .|.. |..  ...||.| .. | . |    |.|.
vrefieellsllaldsg...gpvlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
Y_phosphatase Protein-tyrosine phosphatase 90-175 1.2e-20 69.3 Pfam-A 1-85 (235) alignment 
Range on Protein: 90-175
Range on HMM: 1-85/235.0
NMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKAP
|.. || ..  ..|..||.|  ..|. |..||..|.||..|...| .|.| . .|   ||||| ..| ..| .  . .||...| .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekca
Y_phosphatase Protein-tyrosine phosphatase 90-175 1.2e-20 69.3 In-house 1-85 (235) alignment 
Range on Protein: 90-175
Range on HMM: 1-85/235.0
NMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKAP
|.. || ..  ..|..||.|  ..|. |..||..|.||..|...| .|.| . .|   ||||| ..| ..| .  . .||...| .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekca
subfamily_PTPRG_pd Subfamily PTPRG 74-174 2.2e-20 67.4 In-house 31-133 (563) alignment 
Range on Protein: 74-174
Range on HMM: 31-133/563.0
HTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK---DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQ
.| ... . .  .  .|   ||   .  .|.|||.|.|  ||    |. ||...||| |. |.| .| | .| |   ||||. |.. ..| .  .. |..
etiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkd.tfddFWrmiWeqnvaiivmitnlverg

KRKA
.|| 
rrkc
subfamily_PTPRD_pd Subfamily PTPRD 86-174 1.4e-19 65.2 In-house 44-133 (564) alignment 
Range on Protein: 86-174
Range on HMM: 44-133/564.0
KFLNNMDMNRIPHLYCFDHSRVELAPQDG--KDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRKA
.   |   ||  .   .||||| | . .|  . |. |||..||| |. ||| .|.| .. .|  ||||| |.. |.|     . ||.| | 
nkpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetie.dFWRmvweqnsstiVmltkleEkgkvkc
subfamily_PTPRA_pd Subfamily PTPRA 88-174 8.5e-19 62.6 In-house 56-143 (330) alignment 
Range on Protein: 88-174
Range on HMM: 56-143/330.0
LNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
 .|.. ||....  .|.||| |....|..  |. |||..||| .|  .| || | . .|   ||||. |.| . |... ...|... | 
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke.etvedfwrmiweqksativmltelkerkeekc
subfamily_Ptp69D_pd Subfamily Ptp69D 88-174 4.7e-18 60.3 In-house 47-133 (307) alignment 
Range on Protein: 88-174
Range on HMM: 47-133/307.0
LNNMdMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
 |..  || ...  ||. || |..  ||.  |. |||.. || .|  .| ||.|  . |   ||||..| .  .| .  ...||...| 
enal.knRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPv.eatigDfWRmiaeqevtlivmlsnlteknrkkc
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 90-174 1.6e-17 58.6 In-house 46-131 (318) alignment 
Range on Protein: 90-174
Range on HMM: 46-131/318.0
NMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
|   ||   .  .||.||.| ...|.   |. ||...||| .| ||| ||||  . |   ||||| |.. ..|... .. |. |.| 
nkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpe.tieDfWrmvWeqnsavivmltqeeergkakv
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 79-338 1.9e-17 57.7 In-house 34-216 (392) alignment 
Range on Protein: 79-338
Range on HMM: 34-216/392.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQkrkapy
 ||.|  .   |.  ||      .| .|| |    .  ..|..|||.....  . ||| .|.|    .   ||||| . ... | .  ...| .      
iypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa.slddfwrmvfqenvttiamvtklkegd......

disdrgfeksflhefgaksleecelkakicrkfwpekrskkdfptlsiqasddhsethmktfnltvteKKQDHQTVLM-HFYEWADASkLPEYmldmrAS
                                                                    | .|..||   || || |.  .|..     .|
....................................................................kgddartvaqfhftewPdkd.vpkh.....ts

IKLQYIRS-SKKTGVCIGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRF
  |..|.  . . |    |... |..|| . ..  .|| .|..  . . |   . .. |. .| 
sllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp
Y_phosphatase Protein-tyrosine phosphatase 200-355 2.3e-17 58.6 Pfam-A 78-234 (235) alignment 
Range on Protein: 200-355
Range on HMM: 78-234/235.0
ELKAKICRKFWP-EKRSKKDFPTLSIQAS----DDHSETHMKTFNLTVTEKKQ-DHQTVLMHFYEWADASkLPEYMLDMRasiklQYIRSSKKTG-VCIG
| . . | ..|| |.. .. . .....      .|..|. .....|. .....  ...  .|. .| | . .||   ..      ..||. .|.   . |
ekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg.vpespksll.....dlirkvekskeaksg

PIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
|.. .| .||..... ...||.......|. |  ..... .. ||.|.. ..  |   .....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 200-355 2.3e-17 58.6 In-house 78-234 (235) alignment 
Range on Protein: 200-355
Range on HMM: 78-234/235.0
ELKAKICRKFWP-EKRSKKDFPTLSIQAS----DDHSETHMKTFNLTVTEKKQ-DHQTVLMHFYEWADASkLPEYMLDMRasiklQYIRSSKKTG-VCIG
| . . | ..|| |.. .. . .....      .|..|. .....|. .....  ...  .|. .| | . .||   ..      ..||. .|.   . |
ekgrekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhg.vpespksll.....dlirkvekskeaksg

PIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
|.. .| .||..... ...||.......|. |  ..... .. ||.|.. ..  |   .....
pvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 86-175 3.4e-17 57.6 In-house 52-142 (298) alignment 
Range on Protein: 86-175
Range on HMM: 52-142/298.0
KFLNNMDMNRIPHLYCFDHSRVELAP--QDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKAP
.  .| . || . .  .|.||| |    .| . |. |||....|....|.| .|||..  |   |||||.|.. . | .. .. |..| | .
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte.tvedFWrmvteedigtiVmltnleeldktkyh
subfamily_PTPN9_pd Subfamily PTPN9 84-174 5.8e-17 56.6 In-house 36-127 (297) alignment 
Range on Protein: 84-174
Range on HMM: 36-127/297.0
YDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
. |   |.  ||   . |.|..|| || .|...  |. ||..|||| .| |.| .| |.. .|   ||||| |..  .|..   . |....| 
asklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplk.ktvsdfWrmvWeqevlvivmttrvvergrlkc
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 84-174 6.2e-17 56.7 In-house 40-131 (305) alignment 
Range on Protein: 84-174
Range on HMM: 40-131/305.0
YDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
 .|  .|   ||  .   .|..|. |.... .|  |. |||.||||..| .|| ||.|... |   |||.. | |.| |. . .. | .| | 
vgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkn.tvadfWrliveekvstivmltklveggkdkC
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 88-173 8.9e-17 56.1 In-house 46-132 (319) alignment 
Range on Protein: 88-173
Range on HMM: 46-132/319.0
LNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRK
 .| . || . .  .|..|| |.. ||..  |. |||..||| .....| .||| .. .|  ||||| |.. |....  .. || | |
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentie.dfWrmvWeeessivvmltklveklkvk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 200-357 4.5e-16 54.0 In-house 135-289 (298) alignment 
Range on Protein: 200-357
Range on HMM: 135-289/298.0
ELKAKICRKFWPE-KRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKlPEY---MLDMRASIKLqYIRSSKKtgvciGPIM
||.   . |.||. .  . .  |.|.........  ....... ..... .. . .|| .|.| .  ||.   .||... ..  . . ...      |..
eldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv.penatsvldllrkvra.sqqqagn.....kpvi

LVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
. |. ||..      || .. |. .|. |   ... .....| |  .|   |.   |. ...
vqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 87-165 1.2e-15 52.4 In-house 38-117 (281) alignment 
Range on Protein: 87-165
Range on HMM: 38-117/281.0
FLNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGD
  .|.  ||   .  .|..||...|.  . . |. ||..|.||... .|| .|.|  . . ..||.|| |.| |.| .   
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPa.slvafWqmvweqkvsaivmvtr
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 88-176 1.2e-15 52.4 In-house 7-96 (250) alignment 
Range on Protein: 88-176
Range on HMM: 7-96/250.0
LNNMDMNRIPHLYCFDHSRVELAPQD--GKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRKAPY
..| . ||  ..  .|.||| | ...   . |. |||...||....|.| .|.|... .|  ||||| |.| . |... .. |..|    |
pqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatie.dfWrmvleeksgtivmLtnLkesektyhqy
PTPc_DSPc_SM00012 253-355 1.3e-15 52.8 In-house 4-104 (105) alignment 
Range on Protein: 253-355
Range on HMM: 4-104/105.0
LMHFYEWADAsKLPEYMldmraSIKLQYIRSSKKTGVCI---GPIMLVCATGVEKCAISATIDIIVSRITEE-HRVGFKETMSAIKMQRFGCFRTVGPYS
 .|...| |  ..||..     .  |...|. ||    .   .|....| .|| .... ...||.......| ..| ..........|| |...|   |.
hyhytgwpdh.gvPees.....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqyl

TACEMLM
  ...|.
flyrall
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 90-355 1.7e-15 51.5 In-house 40-290 (301) alignment 
Range on Protein: 90-355
Range on HMM: 40-290/301.0
NMDMNRIPHLYCFDHSRVELAPQDG----KDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRGFEK
|  .||  .   .|. |. |.|.      . .. |||..||||.| ..| ||.|.. .|   |||.. . ||. |..  . .|..| |.    ..   |.
nkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmk.ktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaes

SFLHEFGAKSLEECELKAKICRKFWPEKRSKKDfptlsiqasddhsE-THMKtfNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRaSIKLQYIRSS
.   .|  .  .|. .   . |..    .   .             .   ..  .. |...|. .. . ..  .| .   ..|.   .. .|  . .|  
eefgpftvtlvneqvyPdfvirqlnvkiqdgsn.............ngyier..kfkvksdksswdvlqlqvtdWpqdGvvreprtvLq.viddvihrqq

KKTGvciGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
|  |   ||..  |  .| .  .  ...| .     |  |   .   |.. .. |   |   |..  ... 
kigg...gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid
subfamily_PTPRB_pd Subfamily PTPRB 78-173 1.8e-15 51.8 In-house 39-135 (293) alignment 
Range on Protein: 78-173
Range on HMM: 39-135/293.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRK
..   . ..   | . ||   .  .|||||.||.   . ..|. ||....||. .  .| .| |. . ..  ||||| |.| |.|... .. || | |
kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvd.dfWrmvwekkssiivmltqlvekgkvk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 83-175 1.8e-15 51.7 In-house 42-135 (315) alignment 
Range on Protein: 83-175
Range on HMM: 42-135/315.0
TYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKAP
   |  .| . ||  .   .|.|||.|    .| . |. ||...|||.||  || ||.|    .   |||.| | . . |... .. |..|||| 
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnva.svkdfwrlvfeedigkivmltnlvegekrkae
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 202-360 2.1e-15 51.6 In-house 128-281 (288) alignment 
Range on Protein: 202-360
Range on HMM: 128-281/288.0
KAKICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMRASIKlqYIRSSKKTGvcIGPIMLVCATG
  . | ..||..  .| .  . ... ... .... . .| .  ||.. ..  ...  |.| .  ||   .. . ..   .  ...     |||. .|. |
gktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhg.vPeskapllellr..qvkvanqad..tgpiivhCsaG

VEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
| .  .  ..| .. .. ||  .   .|.. ...||.    |.  |    |.|.. .  
vGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 89-173 3.7e-15 50.7 In-house 46-127 (287) alignment 
Range on Protein: 89-173
Range on HMM: 46-127/287.0
NNMDMNRIPHLYCFDHSRVELApqDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRK
.| | ||. ..   |  || |   . ..|. ||...|||..| |.| |..|  . |   ||... .|... |..  .  |.....
qnkdknRltqilvpdnyrvllk..gehpdyinavfidgykekkafiiaesPmfn.tarnfWkliddrnvtaivmlcqekendeev
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 89-182 3.7e-15 50.9 In-house 47-141 (325) alignment 
Range on Protein: 89-182
Range on HMM: 47-141/325.0
NNMDMNRIPHLYCFDHSRVELA--PQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRG
.|.. || . .  .|.||| |    .|.. |..|||..  . ||  .. ||||  . ..  .||.| . . |...|   .|....| | |   . |
enkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatin.dlWrlvldWrcsvvvvlneldlgkdrcavywpkemg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 79-173 7.4e-15 49.6 In-house 35-132 (290) alignment 
Range on Protein: 79-173
Range on HMM: 35-132/290.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKDD----FYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRK
 .  |..   .|   ||  ..   |  |. | |  |. |    . ||....||..| .|| .|.| . .|   ||... ..| ..|..  .| |..| |
ehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs.ntlvdFWkliwqekvtiivmltniieegkvk
subfamily_PTPN1_pd Subfamily PTPN1 68-174 8.5e-15 49.2 In-house 10-113 (290) alignment 
Range on Protein: 68-174
Range on HMM: 10-113/290.0
ELLNQMHTSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGkdDFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDID
|......  |  .| .  |. .| ..||   .  .||||..|  .|   |. ||| |.    |  ||..| |.  .|   ||.|| |.|   ....  . 
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn..dyinaslveleeakrsyiltqGPlp.ntvdhfWqmvWeqkskavvmlnkvv

EKQKRKA
||.. | 
ekeqikc
0049772 (Phosphotyrosine protein) phosphatases II 82-338 1.1e-14 50.4 In-house 39-255 (314) alignment 
Range on Protein: 82-338
Range on HMM: 39-255/314.0
NTYDKFLNnMDMNRIPHLYCFDhSRVELAPQDGKD-DFYNASWVDGYskkSAYIFAQAPfNDHTEYIF----------WRMV--SERKPSMILV------
 ..|.||| .|.|| .. ...| .|| |  ..... |..|||.|||.    ..| .|.| ...| . |          ||||  ..... .|        
lvadlfln.rdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------FGDIDEKQkrkapydisdrgfekSFLHEFGAKSLEecelkakiCRKFWPEKRSKKDFPTLSIQASDdH---SETHMKTFNLTVTE
               . ..|...               .....   . |.         . ..||. ..  .  | |  .| .   .. ... |   . |
adelsrLdaAlgKtpllildgng...............neptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefiee

KkQdhqtvlmhfyewadasklpeymldmrasiklqyirsskktgvCIGPIMLVCATGVEKCA--ISATIdIIVSRiteehRVGFKETMSAIKMQRF
  .                                            ||.   |. |.   .  . | . ..  .     .| ..|... ....|.
a.d..........................................kggpvlvHCkaGkgRtgtfvvaay.lmkll.....gvsleealedvrlkRp
subfamily_PTPRK_pd Subfamily PTPRK 88-173 1.3e-14 48.7 In-house 41-127 (314) alignment 
Range on Protein: 88-173
Range on HMM: 41-127/314.0
LNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRK
 .| . ||. ..  .|.||| | . ||    |. ||...|.| . .|.| .| | .. | . |||.| . . . |..  .. |... |
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqe.tvkdfWrlvydencasivmltelvevgrvk
subfamily_PTPRD_pd Subfamily PTPRD 200-343 2.4e-14 47.9 In-house 127-266 (564) alignment 
Range on Protein: 200-343
Range on HMM: 127-266/564.0
ELKAKICRKFWPEK-RSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADAS--KLPEYMLDMRASIKLQYiRsskktgVCIGPIML
| . . | |.|||| . . .  | ..... . .. ...||.|. ..... ..    || .| |    . .. .||..  ..    .         |||. 
EkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.e......pdagPivV

VCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRT
 |  ||.   .  .||... ||.||. |   ....|.. ||     |
hCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqt
subfamily_PTPN6_pd Subfamily PTPN6 197-357 9.5e-14 46.1 In-house 131-296 (306) alignment 
Range on Protein: 197-357
Range on HMM: 131-296/306.0
EECELKAKICRKFWPEKRSKKDFPTLSIQASDDHSETH--MKTFNLTV-TEKKQDHQTVLMHFYEWADAS--KLPEYMLDMRASIKLQYIRSSKKtgvCI
.| |   . | ..||.. .|... ..|..  ...| ..  .......  ..||. .. . .|| .| |..  | |. .||.   .. .. .....     
kevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea...ea

GPIMLVCATGVEKCAISATIDIIVSRITEE---HRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|||.  |. |. .      |||... |...     .  ....  .. || |  .|   |    ... |.
gpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPN3_pd Subfamily PTPN3 204-357 1.2e-13 45.7 In-house 124-274 (280) alignment 
Range on Protein: 204-357
Range on HMM: 124-274/280.0
KICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKK--QDHQTVLMHFYEWADAsKLPEYMLDMRASIklQYIRSSKKtgVCIGPIMLVCATG
. | ..|||.  . .. ..|.. . ..... . . .|....|.  .... . . . .|.|  ..|.   |.   .  . .|. ..  .   |... |..|
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdh.gvPddsadflefv..ervrklrs..gkeePvvvhCsaG

VEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
...  .  .... .. | ... |   . .. .. ||    .|.. |   || ..| 
igrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_CG7180_pd Subfamily CG7180 88-170 1.7e-13 44.9 In-house 40-123 (296) alignment 
Range on Protein: 88-170
Range on HMM: 40-123/296.0
LNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQ
..|.. || ..   .|. || |   ||.  .|. ||..||.. || .||  .|| ..  .  |||.| ... | . |  .  . .
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvd.efWrlvydeeisavvvLtktfdfa
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 202-360 1.7e-13 45.4 In-house 89-244 (250) alignment 
Range on Protein: 202-360
Range on HMM: 89-244/250.0
KAKICRKFWP-EKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMldmRASIKLQYIRSSKKTGVCIGPIMLVCAT
. | . ..|| ||  |    |.|.  .. ...  .... |. ..|... . . .||  | | .  ||..   .| ..|.    ...  .  .|... |..
sektyhqywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkg.vPeva...tavLellkkvqasqqqagnaPvivqCsa

GVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
|| .     .|| .. |. .|. |   . . ... .| .  ..   |.   |...|. ..
GvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN12_pd Subfamily PTPN12 76-174 1.9e-13 45.0 In-house 26-125 (290) alignment 
Range on Protein: 76-174
Range on HMM: 26-125/290.0
SAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKD--DFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRK
.  .|...  .  .|.  ||   .  .|.|||||  .....  |. ||... | ..| .|| ||.|.  .|   ||||. | . .....   . | .| |
aekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLp.ktlddfWrmiweknveivvmaCrevelgkkk

A
 
C
subfamily_PTPN9_pd Subfamily PTPN9 202-359 4.1e-13 44.0 In-house 123-291 (297) alignment 
Range on Protein: 202-359
Range on HMM: 123-291/297.0
KAKICRKFWP-EKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHF--YEWADA--SKLPEYMLDMRASIKLQYIRSS-----KKTGVCI
.   |...|| |. | ..|  ||..  ....| . |.  |.... |....  ..||    | |    .  . .||..  .. .   ..     ...| . 
grlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghps

G-PIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAV
| ||.. |..|. .    .|.|| .||. |.  |   ||.. .. ||    .|   |      .. .|.
gPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 88-173 4.9e-13 43.8 In-house 45-131 (288) alignment 
Range on Protein: 88-173
Range on HMM: 45-131/288.0
LNNMDMNRIPHLYCFDHSRVELAP--QDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEYiFWRMVSERKPSMILVFGDIDEKQKRK
 .| . || .    .|. ||.|    .  . |. |||..||. || .|| .|.|  |  .  ||..| |.| | |. . .. |..|.|
avnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvnd.fWelvyenktstivmltelveggktk
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 83-347 5.5e-13 43.6 In-house 36-260 (288) alignment 
Range on Protein: 83-347
Range on HMM: 36-260/288.0
TYDKFLNNMDMNRIPHLYCFDHSRVELApqdGKDDFYNASWVDG-YSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKA-PYDISD
. |.|..|   .|  .|.. | .|| |       ||| |. |      |   | ||||. . |  ..|.|. |     |... .. || |.|.  |  | 
iidsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPl.ngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

RGFEKSFLHEfgaksleecelkakicrkfwpekrskkdfpTLSIQASDDHSETHMKTFNLTVTEKKQDHQ-TVLMHFYEWADASkLPE-YMLDMRAsikL
 | .  . .                                  .. . .  .  .|   | .... ....    .|. || | . .|| |.  .|    |
lGekarigrl..............................ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddg.vPenylsplrl...l

QYIRSSKKtgvcigPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
. ..| .|      ||.. . .|| ...  . | |..  .  .  .| .. ..  . .|| . .|   |
evlkslqk......PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqy
subfamily_PTPRB_pd Subfamily PTPRB 204-356 8.1e-13 43.0 In-house 134-283 (293) alignment 
Range on Protein: 204-356
Range on HMM: 134-283/293.0
KICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMRASIklQYIRSSKKTGVCIGPIMLVCATGVE
. | ..||....   .  ....   ... ..  . .|.....|. ...  .||  |.|    ||    . . .  . .|.....    .||.  |. || 
vkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhg.vPektktlldfv..rtvreaiektaskrPivvhCsaGvG

KCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
.  .  ..| ....|.||  |    ........|.    |.  |    . ...
RtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvld
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 202-356 1.2e-12 42.5 In-house 128-278 (318) alignment 
Range on Protein: 202-356
Range on HMM: 128-278/318.0
KAKiCRKFWPEKRSKkDFPTLSIQASDDH--SETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKlPEYMldmraSIKLQYIRSSKKTG--VCIGPIMLV
||| . ..||.| |.  . .| ......   |.  ...|..| ||...  |    |. .|.| .  ||       .  |. .|...|.      |||.  
kak.vhryWPskgsr.sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegv.pesg.....aslldlvrqvskaqqksgagpivvh

CATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
|..|| .  .  ..||.. || .|  |   .|.. .. ||    .|   |    ..|..
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle
subfamily_PTPN14_pd Subfamily PTPN14 88-175 1.3e-12 42.4 In-house 47-136 (300) alignment 
Range on Protein: 88-175
Range on HMM: 47-136/300.0
LNNMDMNRIPHLYCFDHSRVELAPQ-DGKDDFYNASWVDG--YSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKAP
 .| . ||....  ....||||.|. . .... ||| .     .|.  || ||.|  ..|  .||.|| | . ..|.   .. |. | |. 
penaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl.eltvqdfWqmvWeqgvqlivmlteeeedgkeksf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 79-202 1.4e-12 42.1 In-house 33-154 (315) alignment 
Range on Protein: 79-202
Range on HMM: 33-154/315.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKAPY
.|...  .  .|.  ||      .|..|| |    .. ..|..||| . .. .  ||| .|.| .  .   ||||| . |.. | .  . .|  | |   
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka.svddfwrmvlqekvttivmvtkkqegdkikcrq

DISDRgfeKSFLHEFGAKSLEECELK
   ||   |. . |||. ..|  .|.
ywPdr...kadsvefGsikvellsle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 75-176 2.4e-12 41.6 In-house 36-136 (297) alignment 
Range on Protein: 75-176
Range on HMM: 36-136/297.0
TSAMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKksAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKR
 .|...|.|  .   |.. .|      .| |||.||  . .   |. |||.| |. .   .|  | | .. |   ||.|| . ..|.|..  | .|..|.
peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka.tvadfWamvldeqvstivmlnddnerdkk

KAPY
 | |
cary
0041856 (Phosphotyrosine protein) phosphatases II 90-347 3.1e-12 41.9 In-house 1-160 (182) alignment 
Range on Protein: 90-347
Range on HMM: 1-160/182.0
NMDMNRIPHLYCFDHSRvelapqdgKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGdidekqkrKAPYDIsdrgfeksflh
|.| || .. ...||||          |. ||....|. . . .| .|.| .. | . |.||. |.. ..|.             .|.            
nldknrysdilpydhsr........dldyInanlylgslpatrfiatqgplls.tvadflrmlkelgittivnlt........eelywp...........

efgaksleecelkakicrkfwpekrskkdfptlsiqasddhsethmktfnltvteKKQDHQTVLMHFYEWADASKLPeymldmrASIKLQYIRSSKKtgv
                                                       ..  .. .  ... | | .  .        .. |..|.  ..   
.......................................................ellerlgiqylylpwpDhgvpd.......ldelldfieevle...

CIGPIMLVCATGVEKCAISATIDIIVSRiteehRVGFKETMSAIKMQRFGCFRTVGPY
  ||.   |  || . .  . .... ..     .|.. |... ....|.|.. |   |
eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqy
subfamily_Ptp69D_pd Subfamily Ptp69D 200-357 3.2e-12 41.2 In-house 127-285 (307) alignment 
Range on Protein: 200-357
Range on HMM: 127-285/307.0
ELKAKICRKFWPEKrSKKDFPTLSIQASDD--HSETHMKTFNLTVTEKK----QDHQT-VLMHFYEWADaSKLPEYMLDMRASIKlqYIRSSKKTGvcIG
| . | | |.||.   .. .  . ..  .   ||.  ....... ....    .|..  |  |. .| | || ||    .   |.   .|. .|.    .
eknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkD.skvPevargllklie..qvrelykln..rs

PIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
||.. | .||.. .|  ..|... .. .|..|   ||.  .. ||   ..    |.     |...
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 199-357 5.7e-12 40.1 In-house 126-282 (290) alignment 
Range on Protein: 199-357
Range on HMM: 126-282/290.0
CELKAKICRKFWPEKRSKKdFPTLSIQASDDHSETHMKTFNLTVTEKK--QDHQTVL-MHFYEWADASKLPEYMLDMrASIKlQYIRSSKKTGvcIGPIM
 | . . |...||.. .|. .   ||. ..... ... . .| |..|.  ...|.|   ..  | .  |....   .  .|. . ..  .|.|   ..|.
ieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil.lvie.emyktqrkrg..ntsiv

LVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
. |  .| . |.  .... . .   |  .   . .   ..|. |   ||  | . ...... 
vHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 92-171 6.4e-12 39.6 In-house 50-130 (439) alignment 
Range on Protein: 92-171
Range on HMM: 50-130/439.0
DMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEYiFWRMVSERKPSMILVFGDIDEKQK
  ||   .  |||.|| |   |   .  ..|| ...|| ..  || .|.| .. |.  |||.| |.| . |... .. |  |
tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettdd.fwrlviekktvtivmltnlvesyk
subfamily_PTPN23_pd Subfamily PTPN23 90-173 7.7e-12 39.6 In-house 43-124 (288) alignment 
Range on Protein: 90-173
Range on HMM: 43-124/288.0
NMDMNRIPHLYCFDHSRVELApqDGKDDFYNASWVDGYSKKS-AYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRK
. . ||   .  .||.|| |   ..|||. |||.| . |  .  .| .||| .  |   ||.|| |.| |.| .  . .|..| |
yseknrsrdilPyDhnRvklr..gskDDYinAsfvkdlspgcPdfiatqaPlq.stlnDFWlmvyeqkssviVmllskeelgkpk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 200-348 9.2e-12 39.7 In-house 127-274 (297) alignment 
Range on Protein: 200-348
Range on HMM: 127-274/297.0
ELKAKICRKFWPEKRSKKdFPTLSIQASDD--HSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPeymlDMRASIKLQYIRSSKK--TGVCIGPIM
. . | |...|..| ... | ..|.. .     .    .....|  . |. .     .| || | .         .||  |..|   .|   ..  ||..
nerdkkcaryWsdkgvtt.fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver....kdsassllklisevrkdfsqnaegPll

LVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYS
. | .|| . ..  ||| .|... .|. |   .... .. .|    .|   |.
vhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqyk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 204-347 1.5e-11 38.7 In-house 126-266 (315) alignment 
Range on Protein: 204-347
Range on HMM: 126-266/315.0
K-ICRKFWPE-KRSKKDFPTLSIQASDDHSETHMKTFNLtVTEK-KQDHQTVLMHFYEWADASklpeymLDMRASIKLQYIRSSKK-TGVCIGPIMLVCA
|  ||..||. |    .| .....  . .. | . . .| || | .. ..    .| || |         | ..|  |..|.  |   |    .... |.
kikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkG......vdkqtssllklikevkadngkkefsllvhcs

TGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
.|| .  .  .|| .|..| ... |   ...  .. .|    .|   |
aGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeey
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 202-360 2.7e-11 38.2 In-house 127-285 (305) alignment 
Range on Protein: 202-360
Range on HMM: 127-285/305.0
KAKICRKFWPEKRSK-KDFPTLSIQASDDHSETHMKTFNLTVTE---KKQDHQTVLMHFYEWADASkLPEYMLDMRASIKLQYIRSSKKTGVcigPIMLV
. . ||..|||. .. |.|  .|.. .. .. .   . .|...    .|.... . ... .| |    |..   .   ||    . .|  ||   |.. .
gkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhG.vpqfatsllslikrvqkdqkkdkgv...pllVh

CATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
|  || .  .  ..|| . |. .|  | . | . ... .| .   |   |    ..| .   .
CsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 83-162 3.2e-11 37.4 In-house 40-113 (303) alignment 
Range on Protein: 83-162
Range on HMM: 40-113/303.0
TYDKFLNNMDMNRIPHLYCFDHSRVELApqdgKDDFYNASWVDGYSKKSAyIFAQAPFNdHTEYIFWRMVSERKPSMILV
. ..|..||| ||.  . |.|||.|.|.       .  ||...  |.| | |..| |.. ||   ||.|. |.|   .|.
sknqfvknmdknrfvdvicldhskvkls....dssyihasyleldsskka.iltqlpls.htaadfwqmiieqkvkcvll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 79-173 3.3e-11 37.0 In-house 32-127 (515) alignment 
Range on Protein: 79-173
Range on HMM: 32-127/515.0
TYPNTYDKFLNNMDMNRIPHLYCFDHSRVEL--APQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRK
 ||.|  .   |   ||      .| .|| |    .. . |..||| . ..    ||| .|.| .  ..  |||.| . ... | .  .  |  | |
iypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd.dfWrlvlqenvttiamvtklkegdkik
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 203-358 4.4e-11 37.3 In-house 103-264 (270) alignment 
Range on Protein: 203-358
Range on HMM: 103-264/270.0
AKICRKFWPEKRSK---KDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLQYIRSSKKTGVC---IGPIML
 | | ..||... .     . .... |. .. |.   . .|...|| . .. |  ....| | .  .|    ....  |. .|  ...       .|.. 
rkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

VCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
 |. ||..  .  ..||.|  . |...|   . ..... .|  . ...  |  . . ....|
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_PTPN23_pd Subfamily PTPN23 199-334 4.9e-11 37.0 In-house 118-256 (288) alignment 
Range on Protein: 199-334
Range on HMM: 118-256/288.0
CELKAKICRKFWPEKRSK-KDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTV--LMHFYEWAD--ASKLPEYMLDMRASIKLQYIRSSKKTGVcigP
 ||. . . ..|||.. . . |. ||.  .. ..  ..   .|... ...|.     .... .|..  . . || .|..   .. .|    .|. .   |
eelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt...P

IMLVCATGVEKCAISATIDIIVSRITEEHrvGFKETM---SAIK
... | .||..  . | .  .|  .....  |  ...   | ..
lvvhCsaGvgRtgvfalvyaavrelekgn..glldiiqvvsrlr
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 87-173 5e-11 37.1 In-house 17-105 (270) alignment 
Range on Protein: 87-173
Range on HMM: 17-105/270.0
FLNNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWVDGYSK-KSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRK
. ..  .||   .    ..|| |..   | .  ..|| .| |... | .|| |..|  . |   ||||. |.| . |..  .. || ..|
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPl.pttlksfwrmiweekvtaivmttgleEkgrkk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 83-172 8.3e-11 36.0 In-house 45-134 (310) alignment 
Range on Protein: 83-172
Range on HMM: 45-134/310.0
TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDG-KDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKR
||. . ..|  ||   . | | ||| |  .    .|.  | .|     .|..| .| |. .||   ||||. . .   ||..  . |. . 
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgpl.qhtiidfwrmifqeraesilllckvgeegrp
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 74-170 8.8e-11 36.1 In-house 24-119 (287) alignment 
Range on Protein: 74-170
Range on HMM: 24-119/287.0
HTSAMTYPNTYDkfLNNMDMNRIPHLYCFDHSRVELA--PQDGKdDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVF-GDIDEKQ
..|..|. .. .  | ..  ||  ..  .|..|| |.  .. |  |. || .| .| .. |.| ||.|.   |   |||.| |.. . ...   ...| .
esstatfkaaee..laavkknryadvlPiddtrvllsaegelGs.dyinanyvasytddeafiaaqgPiaa.tvrdfwravletrsasvitmtreveear
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 89-163 8.9e-11 36.3 In-house 32-103 (267) alignment 
Range on Protein: 89-163
Range on HMM: 32-103/267.0
NNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVF
.| ..||. .   .|..|| |  .. .... |||.|.|| .| |.|  | |..  |   |. .. ..| ..| . 
knqernrlddnlpyddtrvil..rtkeeeyinasyvegyktknafivtqdplkn.titdfltvihdqkvpvivll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 198-357 1.2e-10 35.9 In-house 120-277 (287) alignment 
Range on Protein: 198-357
Range on HMM: 120-277/287.0
ECELKAKICRKFWPEKRSkKDFPTLSIQASDDHS--ETHMKTFNLTVTEKKQDHQTVL-MHFYEWADASKLPEYMLDMRaSIKlQYIRSSKKTGVciGPI
| | . ..| ..|||..|   .   .|.  ...   .  ....... ..|..|.|.|   .. .| .  |..|.   .   |. . ... .| |   ..|
ekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill.vie.emyktqrkrgn..tsi

MLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
.  |. .| . |.   ... . .  .|  .   . .   ..|. |  .||  |   .......
vvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 203-346 1.8e-10 34.5 In-house 124-264 (515) alignment 
Range on Protein: 203-346
Range on HMM: 124-264/515.0
AKI-CRKFWPEKRS-KKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEymldmrASIKLQYIRSSK-KTGVCIGPIMLVCA
 || | |.||.| .    | .....    .. | .   .|||.  .. .     || || |    ..      .|  |..|.  | ..|    |... |.
dkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkh......tssllklikevkadhgqythpliihcs

TGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGP
.|| .  .  .|| .|... . . |   ...  |. .|    .|   
aGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 202-358 2.5e-10 34.8 In-house 130-279 (315) alignment 
Range on Protein: 202-358
Range on HMM: 130-279/315.0
KAKICRKFWPEKrsKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWAdASKLPEYMLDMrasikLQYIRSSKK-TGVCIGPIMLVCAT
. . . |.||.|  |  .  ...   ..  .|..    |.|. ... .. | .|.  |   ...|.| . .     ...||  |.     .|.|.. |  
ekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswp.dmgvpkytipl.....mnlirtvkqhhtnsvgaivvhcsa

GVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
|| .     |.| .. ..  |. .   . .  .. .| .  ...  |    ..|..  
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_PTPN13_pd Subfamily PTPN13 204-347 6.3e-10 33.8 In-house 117-258 (273) alignment 
Range on Protein: 204-347
Range on HMM: 117-258/273.0
KICRKFWPEKRSKKDFPT----LSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMrasikLQYIRSSKKTGVCIGPIMLVCA
  |...|||...||   .    ..     ....  ....... .| .. .. . ..| .| | .  |   ...     ||...  ..     |||.  |.
vkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhg.vPssaael.....lqfvaevrrlqtdagPivvhcs

TGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
.|. .  .  |||...  |  .. .  ||..  .. || |  .|   |
aGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqy
subfamily_PTPN3_pd Subfamily PTPN3 86-173 7.8e-10 33.1 In-house 37-125 (280) alignment 
Range on Protein: 86-173
Range on HMM: 37-125/280.0
KFLNNMDMNRIPHLYCFDHSRVELApqDGKDDFYNASWVD----GYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRK
.  .|.. ||   .  .|. ||.|   ... |. ||..|.    . .    || .| |.. .|   ||.|| |.| |.|... .. |. . |
rkpenlsknryrdilpydatrvklk..esetdyinanyvnmeipstglvnryiatqGPla.ktatdfWqmvweqksslivmlttlverGrvk
subfamily_PTPN6_pd Subfamily PTPN6 43-173 8e-10 33.2 In-house 10-139 (306) alignment 
Range on Protein: 43-173
Range on HMM: 10-139/306.0
EGKEEEVNKnvTPEEAFKAVTVEGPELLNQMHTSaMTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGK-DDFYNASWVDGYSK--KSAYIFAQAP
| ...|..|  . |.  ||   |  | |.|....  ..  .  .  .|.  ||.     |||.|| |. .. . .|. ||. ... .|  . .|| .|  
eqrvselek..eeeslekagfeeefeelqqeeak.kllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgc

FNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRK
... |   ||||| . .  .|..     |. | |
let.tvsdFWrmvwqensrvivmttkevErgkek
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 82-174 8.2e-10 33.0 In-house 25-117 (283) alignment 
Range on Protein: 82-174
Range on HMM: 25-117/283.0
NTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGkdDFYNASWVD---GYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
 . .   .|  .||  ..   |  |||| ..    |. ||...     | ..  || ||.|. |.|   ||.|| ..| . |...  . | .. | 
adiasadenkrknrnqeivpadqwrvelksesr..dyinavfipvsksykqdkkyiiaqsPl.drtvvdfWkmvfdekitaivmltklqedlrikC
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 88-174 1.4e-09 32.5 In-house 26-115 (274) alignment 
Range on Protein: 88-174
Range on HMM: 26-115/274.0
LNNMDMNRIPHLYCFDHSRVELAPQDGKDD---FYNASWVDGYSKK-SAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
  .   ||   .   ..||| | .....|.   . || .. ||...  ||. .| |.  .|   ||||. ... ..|..  .. |....| 
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlp.ntvadfWrmiyqeevqvivmltklkeaneqkC
subfamily_egg_pd Subfamily egg 88-215 1.5e-09 32.0 In-house 38-132 (307) alignment 
Range on Protein: 88-215
Range on HMM: 38-132/307.0
LNNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKqkrkapydisdrgfek
 ||..  | ... | | |||.|  . |.  |||  |  |.|      .| ||||. . |   ||||| . .   |...    |                 
dnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkn.tvddfwrmvfqeevqyivmltsrkes................

sflhefgaksleecelkaKICRKFWPEKRS
                  . |  .||   |
..................erceyywpkaes
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 89-170 1.7e-09 31.6 In-house 95-175 (244) alignment 
Range on Protein: 89-170
Range on HMM: 95-175/244.0
NNMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQ
||   ||      || .|| |.     . . |||.|    . . ||..| |. | |   ||.|. ||.  ...|.| ..|..
nnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhplad.tsmdfwkmmlerhvnvlvvlgsveeed
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 205-358 1.8e-09 32.1 In-house 132-283 (319) alignment 
Range on Protein: 205-358
Range on HMM: 132-283/319.0
ICRKFWPEKRS-KKDFPTLSIQASDDHSETHMKTFNLTVTEKKQD-HQTVLMHFYEWADAsKLPEYMLDMRASIKlqYIRSSKKTgVCIGPIMLVCATGV
 ..|.|||.   .    .. ..  .  ..  .. ..|     . .  . .  .. ||.|  . ||. . . . .|   || |..     |||.  |. ||
klkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdh.dvPekatslldllk..rirksrek.tqsgPivvhCsaGv

EKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
 .     ..|... |. ||  .   .|.| ...||    ..   |.   | |....
GRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 91-173 2.2e-09 31.9 In-house 4-86 (237) alignment 
Range on Protein: 91-173
Range on HMM: 4-86/237.0
MDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTEYiFWRMVSERKPSMILVFGDIDEKQKRK
   ||   . ..||||| |    .. |. ||....|.      || || |..   .  ||.|| . | |.|...  . |... |
kiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscdd.fwqmvwqekcsvivmltgliegnelk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 202-347 2.2e-09 31.9 In-house 125-265 (281) alignment 
Range on Protein: 202-347
Range on HMM: 125-265/281.0
KakiCRKFWPEKRSKKDFPTLSIQASDDHSETH--MKTFNLtVTEKKQDHQTVLMHFYEWADA--SKLPEYMLDMRASIKlQYIRSSKKtgvciGPIMLV
|   | ..||...|.  . .. ..    .....   ..|.|  .|. .  . . ...  | |    . .. .|. |. .. .. ....|      |... 
k...ChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevl.kltekktk.....aplvih

CATGVEKCAISATIDIIVSRITEE-HRVGFKETMSAIKMQRFGCFRTVGPY
|..|| .     ..| .|.....| ...  |...  .. .|    .||  |
CsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqy
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 202-360 2.2e-09 31.5 In-house 118-279 (287) alignment 
Range on Protein: 202-360
Range on HMM: 118-279/287.0
KAKICRKFWPEKRSKKDFPTLSIQASDDH---SETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKL-QYIRsSKKTGVCIGPIMLV
  . | |.|||..        |. . |      |  .... |   | .. .    .....| | .  |  .  .|  ..  |.|   .. .  .||... 
arlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie.lardasevGPlvvh

CATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVT
. .|. .  |  .. ..|||  .  ||    ..  ....| .  ..|  .   .| |. .  |
ddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
0051429 (Phosphotyrosine protein) phosphatases II 116-357 3.8e-09 32.1 In-house 4-224 (272) alignment 
Range on Protein: 116-357
Range on HMM: 4-224/272.0
DDFYNASWVDGYSK---KSAYIFAQAPFNDhTEYIFWRMvSERKPSMILVFGDIDEKQKRKAPYDISdrgfeksflhefgaksleecelkakicrkfwpe
.. .||..|.|| .   . ... ...| .  |.  |||.  | . ..|. . . .|... | .. .                                  
sgyiNardvggygrvvkpgrlyrsggplpl.taadfwrl.kelgiktivdLrseeErgrlkcdrywp.................................

krskkDFPTLSIQASDDHSETHM-------------------KTFNLTVT-EKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLqyirsskktgvcIG
     ..  | .   ||. .|.                     .. || .   .. ..  ..|.. | | .  .|..|.. . .               |
.....girylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld............gg

PIMLVCATGVEKCAISATIDIIVSRITEEHRVG--------FKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|..  |. |.   .. . ..... ....|  |           |... .. || | . | . |   .| |...
pvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 200-359 4.4e-09 30.8 In-house 109-269 (274) alignment 
Range on Protein: 200-359
Range on HMM: 109-269/274.0
ELKAKICRKFWPEKRSK---KDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADAsKLPEY---MLDMRASIklqyIRSSKKTGVCIGP
| . . | ...|....    . .  ..|. ..  .. . .  .|.. . .. .. . . . .| |  | |.    .||. . .     .| ...   ..|
eaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdh.ksPddantlldlvlev....eesreeenaklap

IMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAV
... |. |. .  .  .|.| | .. ||. |   .... ....| |  .|   |    ..|.... 
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPRN_pd Subfamily PTPRN 89-183 4.9e-09 30.3 In-house 55-151 (297) alignment 
Range on Protein: 89-183
Range on HMM: 55-151/297.0
NNMDMNRIPHLYCFDHSRVELAPQ--DGKDDFYNASWV-DGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRGF
.|.. ||  ..  .|||||.|  .  . |.|. ||| . |   ...||| .|.| . .|   ||.|| |.   .|. .  ..|.. ..      | | 
knvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpla.stvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGs
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 197-358 6.9e-09 30.3 In-house 123-288 (325) alignment 
Range on Protein: 197-358
Range on HMM: 123-288/325.0
EECELKAKICRKFWPEK-RSKKDFPTL--SIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWAD--ASKLPEYMLDMRASIKLQYIRSSKKtGVCI
.| .|. . | ..||..    | | .|  .... .. |.  .. ...  ..| .      ...  | |    | |  .. .   .|    |   .   . 
neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan.tkas

GPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
.||.. |..|| .. . ...  .. .. || ||   . .  .. .|    .||  |.   | |... 
tpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_eak_pd Subfamily eak 88-357 8e-09 29.3 In-house 50-304 (332) alignment 
Range on Protein: 88-357
Range on HMM: 50-304/332.0
LNNMDMNrIPHLYCFDHSRVELAPQ-DGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTeYIFWRMVSERK-PSMILVFGDIDEKQKRKAPYdISDRGFEK
|.... | . ..  .|.  |.|..    .. . ||| ..       ||.. .. .|.  ..||.|| |.| |... .  |...| ..   |   |.. |.
leavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkv.fafwqmvleqkspaivqlledvelkleksdky.fpdktree

sflHEFGAKSLEecelkakiCRKFwpEKRSKKDFPTLSIQA-SDDHSETHMKTFNLTvtEKKQDHQTVLMHFYEWADASKLPeYMLDMRASIKLQYIRSS
    .||   .|        ...|   ||.. ..  | ..   . |   | | |  |  | .      .. ...       .  .. |....   ...  
...lkfGildve........rkef..vkrniletrllelskGnethrvlhykvfGwt..ettlpkyedflalrkvmkevGvl.llivmksallsstlkky

KKTGVCIGPIMlVCATGVEKCAISATIDIIVSRITEEHRVG--FKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
..|  .  ||.  .|.|  .. .   ||...  | .  .     .. .  .| .|  .  .   .|   |.....
ihtppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldy
0043147 (Phosphotyrosine protein) phosphatases II 114-345 9.4e-09 30.7 In-house 3-148 (172) alignment 
Range on Protein: 114-345
Range on HMM: 3-148/172.0
GKDDFYNASWVDGYSKKSAYIFAQAPfNDHTEYIFWRMVSERKPSMILVFGDIdekqkrkapydisdrgfeksflhefgaksleecelkakicrkfwpek
. .|..|||..|.| .   .|  |.|  ..|   ||||. |.. ..|.   .                                                
egsdyinasyldlyyipdrfiatqgp.lrntladfwrmlkelgithivnltel...............................................

rskkdfptlsiqasddhsethmktfnlTVTEKKQDHQTVLMHFYEWADASK-LPEYMLDMRASIKLQYIRSSKktgvciGPIMLVCATGVEKCAISATID
                           ... ..  .. .  ... | | .  |.|..|..   |.  ...|..      ||.   |  ||   .  . ..
...........................lydpellerlgiqylylpwpDhgvpllellleflefidellalspg......gpvlVHCsaGvgRtgtlvaay

IIVsriteeHRVGFKETMSAIKMQRFGCFRTVG
..       ... . |... ....|.|.. . .
lml......lglsleeavalvrekRpgavqnps
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 69-173 1.7e-08 28.9 In-house 18-123 (307) alignment 
Range on Protein: 69-173
Range on HMM: 18-123/307.0
LLNQMHTSAMTYPN--TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDGKDDFYNASWVDGYSKKSAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDI
| ....  |   |.  | . |  | | ||   . | |..|. .  .    |.  | ..    |   .| || |  . | | || |. . |   .... ..
lvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgpl.entqysfwamaiqekvesvimlckv

DEKQKRK
 |  | |
ielakik
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 84-162 1.9e-08 28.1 In-house 45-123 (302) alignment 
Range on Protein: 84-162
Range on HMM: 45-123/302.0
YDKFLNNMDMNRIPHLYCFDHSRVELapQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDHTEYI--FWRMVSERKPSMILV
   | .|...|. ... . |. .| |  .  .|...||| |.  . .   | || |  | .. .  ||||| ..|  .. .
Ckafkknlkknqsedvpildsnlvkl..eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvi
subfamily_PTPRA_pd Subfamily PTPRA 200-358 2.1e-08 28.5 In-house 137-295 (330) alignment 
Range on Protein: 200-358
Range on HMM: 137-295/330.0
ELKAKICRKFWPEKRSKkDFPTLSIQASDDH--SETHMKTFNLT----VTEKKQDHQTVLMHFYEWADASkLPEY---MLDMRASIKlqyirssKKTGVC
| | . | ..||.. .   .  . ..  |.    .  .. | ..     |..|.  .   .||  | |   .|     ||.. . .|       |.  . 
erkeekcaqywPdeGlv.tyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvG.vPfepiGmlkllkkvk.......klnqqs

IGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFA
 |||.. |..|| .     ..| .. |.  |..|   |... ...||    .|   |    ..|... 
agpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_CG42327_pd Subfamily CG42327 109-176 2.3e-08 28.1 In-house 49-117 (319) alignment 
Range on Protein: 109-176
Range on HMM: 49-117/319.0
LAPQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQ-KRKAPY
  ..| || . .||.| || . .. || ||.. .| .   |||.| |..  .|.   |. |.  |. | |
rigdddkdeyldasyvrGyddapnsyiaaqvsledsss.dfwrtvweqqsrvivqltdlselGikvcaey
subfamily_PTPN12_pd Subfamily PTPN12 198-322 2.9e-08 28.0 In-house 117-238 (290) alignment 
Range on Protein: 198-322
Range on HMM: 117-238/290.0
ECELKAKICRKFWPEKRSKKD-FPTLSIQASDDHSET-HMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLDMRASIKLqyIRSSKKtgVCIGPIM
| ||. | |...|||.  ..  | ..... ....  .  .    |.|. .|. ..   .|. .| |    |. . .. . |.|  .|. ..      |..
evelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhg.vPssakslleliel..vrelqe..sedaPlv

LVCATGVEKCAISATIDIIVSRITEEH
. |. || .  .  .||.. . . .|.
vhCsaGvGrtGtiiaidyvrellkaek
subfamily_PTPN14_pd Subfamily PTPN14 204-357 3.5e-08 27.8 In-house 133-295 (300) alignment 
Range on Protein: 204-357
Range on HMM: 133-295/300.0
KICRKFWPEKRSK---KDFPTLSIQASDDHSETHMKTFNLTVT--EKKQDHQTVLMHFYEWADASkLPEY---M---LDMRASIKLQYIRSSKKtGVCIG
. . |..|.. ||    .|    ...   .. . . |  |..     |.. . . . . .|.|   .||    .   |..  |.. .  ....       
eksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhg.vPeDvkgflsyLeevqsvrrktnseves.keskP

PIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKF
|... |. || .  .  . |.... .  ....  |.... .. ||    .|.. |    ..|.|.
PvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_CG7180_pd Subfamily CG7180 203-356 3.7e-08 27.3 In-house 123-288 (296) alignment 
Range on Protein: 203-356
Range on HMM: 123-288/296.0
AKICRKFWPEKRsKKDFPTLSIQASDDHSETHMKTFNLTVTEK-----------KQDHQTV-LMHFYEWADASKLPEY---MLDMRASIKLQYIRSskKT
|| . ..||.|  |...  . ..    .. ...|. .. .| |           | .  .| |... ||    |.|     ....|  ..|   .   . 
akmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekv..de

GVCIGPIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMK
    ||.. |.  |. .  .  .||. .  . .|..| . | .  .. .| .   .|  |    ..| .
dpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 86-198 4.6e-08 27.1 In-house 39-149 (312) alignment 
Range on Protein: 86-198
Range on HMM: 39-149/312.0
KFLNNMDMNRIPHLYCFDHSRVELApqdGKDDFY-NASWVDGYSKKSAYIFAQAPFNDHTEYiFWRM-VSERKPSMILVFGDIDEKQKRKAPYDISDRGF
 ||.  |.|| | . |.|  |  ||   | ..||  | .|   .|   .. .|.|... . . ||.. .|    |.||. | ...  .. | |     ||
aflkfkdlnrypniqcwdrgrftla...gdenfyihanfvkictkperfvctqgplentcth.fwqlalslgstsiillcgfvedgsekcakyisdivgf

EKSFLHEFGAKSLEE
 .   |   ...  |
vdledhrvyteycte
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 78-168 4.7e-08 27.3 In-house 23-111 (285) alignment 
Range on Protein: 78-168
Range on HMM: 23-111/285.0
MTYPNTYDKFLNNMDMNRIPHLYCFDHSRVELAPQDgkDDFYNASWVDGYSK-KSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDE
|    ||  .  | |.||   . | . .|| |  .|   |.  |||.    | .|.|| .| |. . |   ||.|. . | . .|..  . |
mppnctytayeanpdlnryadvrcieetrvvlknhd..rdyihaswmrmpgkdqstyittqgplpe.tlsdfwhmiyqekiayvlmlctlfe
subfamily_PTPRG_pd Subfamily PTPRG 202-355 7.1e-08 26.1 In-house 129-284 (563) alignment 
Range on Protein: 202-355
Range on HMM: 129-284/563.0
KAKICRKFWPEkRSKKDFPTLSIQ--ASDDHSETHMKTFNLTVTE---KKQ-DHQTVLM--HFYEWADASkLPEYMLdmrasIKLQYIRSSK-KTGVCIG
... |  .||.    ... .|...  ... ..   ..|. .  ..   ||| |.. . .  |. .| | .  ||. |      .|.... |.  .   .|
grrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhg.vPehsl.....pvLifvkkssaankaeaG

PIMLVCATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLM
||.  | .|| .  .   .| .. .| .|. |   ...  |..||   . |   |    . |.
PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdall
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 74-137 7.3e-08 26.5 In-house 30-94 (95) alignment 
Range on Protein: 74-137
Range on HMM: 30-94/95.0
HTSAMTYPN--TYDKFLNNMDMNRIPHLYCFDHSRVELAPQDgKDDFYNASWVDGYSKKSAYIFAQ
.. .||     |      |.  ||.  .. .| .|| |. .    |. || .||||..| .|| ||
ksismtsgapytvgsseanipknrflnifpydatrvvlttkr.dsdyinacfvdgyarkncyiaaq
subfamily_PTPN1_pd Subfamily PTPN1 201-344 7.4e-08 26.4 In-house 108-257 (290) alignment 
Range on Protein: 201-344
Range on HMM: 108-257/290.0
LKAKICRKFWPEKRS--KKDFP--TLS--IQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADAS--KLPEYMLDMrasikLQYIRSSKKTGVCIG
 .   | ..||.. .  .  .   .|.  . . ...|.  .....|.  . .. .. . .|.  |.| .  . | ..|..     |. .|.|       |
keqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkf.....lfkvresGslssdvG

PIMLVCATGVEKCAISATIDIIVSRITEEHR---VGFKETMSAIKMQRFGCFRTV
| .. |..|. .    . .| .. .| ...    |  |... ... .|.|  .| 
pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqta
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 89-174 1.8e-07 25.1 In-house 53-136 (290) alignment 
Range on Protein: 89-174
Range on HMM: 53-136/290.0
NN--MDMNRIPHLYCFDHSRVELApqDG-KDDFYNASWVDGYskKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKA
.|  .  ||   . | | .|| |   || . |.  | .|.|   |. .|..| . .| |   .|||| . | ..| .. .. |. | | 
kntefkknrykdvvcndktrvilk..dGydGdyvhanyvkGl..kamfiltqGalkd.tvidiwrmvlqekvaaivmlceliedGkakc
subfamily_PTPRK_pd Subfamily PTPRK 203-347 2.5e-07 24.8 In-house 125-266 (314) alignment 
Range on Protein: 203-347
Range on HMM: 125-266/314.0
AKICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTV--LMHFYEWADAsKLPEYMLDMRASIKlqYIRSSKKTgvCIGPIMLVCAT
.  | |.|||. .. .   . .  .. ..|  ...|... ....|. . .   ..|  |.|  . | .   . . ..   . .|..     |.|.. | .
rvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvr..rvkksqee..eaGrivvhCsa

GVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPY
|  .  .  .|||..  | .|. |   ... ... ..     |   |
GaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqy
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 202-361 3.3e-07 24.2 In-house 133-286 (290) alignment 
Range on Protein: 202-361
Range on HMM: 133-286/290.0
KAKiCRKFWPEKRSK-KDFPTLSIQASD-DHSETHMKTFNLTVTEKKQDHQTVLMHFY--EWADASklpeymLDMRASIKLQYIRSSKKtgvCIGPIMLV
||| | ...|||  .   |  ...  |  |. .....   |.| .|.. .. .| |.    | | |      . . .   |. .|. .|     ||... 
kak.ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdks......valstlallrtlrilrk...asGpvvvh

CATGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAVTT
|..|. .    ..|.. .  ... . .   ... |..  | .  .    | .  |.|... .  
csaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 90-173 3.8e-07 24.5 In-house 8-94 (239) alignment 
Range on Protein: 90-173
Range on HMM: 8-94/239.0
NMDMNRIPHLYCFDHSRVELA--PQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTEyIFWRMV-SERKPSMILVFGDIDEKQKRK
|   ||   .  .||||| |    .| . |. |||..  |     ||| .|   .  .   ||||.  ||.  .... | |. ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissg.dfwrmmwqerrcvivmltglieghkkkc
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 90-173 4e-07 24.4 In-house 7-93 (239) alignment 
Range on Protein: 90-173
Range on HMM: 7-93/239.0
NMDMNRIPHLYCFDHSRVELA--PQDGKDDFYNASWVDGYSK-KSAYIFAQAPFNDHTEyIFWRMV-SERKPSMILVFGDIDEKQKRK
|   ||   .  .||||| |    .| . |. |||..  |     ||| .|   .  .   ||||.  ||.  .... | |. ..|. 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissg.dfwrmmwqerrcvivmltglieghkkkc
0036282 (Phosphotyrosine protein) phosphatases II 116-341 4.5e-07 25.2 In-house 2-153 (174) alignment 
Range on Protein: 116-341
Range on HMM: 2-153/174.0
DDFYNASWVDGYSKKSAYIFAQAPFNdhteyiFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDrgfeksflhefgaksleecelkakicrkfwpekrs
.|..|||..|..   . .|  |.|..      ||.|. | . .... . .  |... | .   ..                                   
sdyinaspldlsyitprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe...................................

kkdfptlsiqasddhsethmktfnltvTEKKQDHQTVLMHFYEWADASKLPEYMLDMRASIKLQYIRSskktgVCIGPIMLVCATGVEKCAISATIDIIV
                           . .   .  .  ... | | .  .  .|.   ..  ... .        ||.   |  ||   .. . .... 
...........................lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.....dpggpvlVHCsaGvgRtGtlvaaylml

SRITeEHRVGFKETMSAIKMQRFGCF
 ..  |  |   ... ....|| |..
rgll.eslvdaldlvrelRlqrpgmv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 203-359 7.1e-07 23.4 In-house 114-267 (283) alignment 
Range on Protein: 203-359
Range on HMM: 114-267/283.0
AKICRKFWPEkRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASKLPEYMLdMRASIKLQYIRSSKkTGVCIGPIMLVCATGV
 . | ..||. |  .|.  . .   .. ..  .   .|..  .   ..|.|.  |   |  .  |    . . .|.  ..| . |    |||.. |.||.
rikCsqyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqai.inslvkfnkvislq.teskkgPivvhCstgi

EKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRTVGPYSTACEMLMKFAV
 . |.  ..   |  .  |  |   ...  .. || .  .| . |    |. .. |.
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 91-195 8e-07 23.1 In-house 51-153 (301) alignment 
Range on Protein: 91-195
Range on HMM: 51-153/301.0
MDMNRIPHLYCFDHSRVELApQDGKDDFYNASWVDGYSKKSAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDRGFEKSFLHE
 | .| |.. |  .. ||.  .|||     | |..   .   .| .|.|... | . || |.   .   | ..|   ||...|  . .. .  ||  .  
kdkhryptvPckPstavevi.vdGkrvPihanwiptsGhphrfiatqgPlkn.tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

FGAKS
|  | 
fkiki
0049260 (Phosphotyrosine protein) phosphatases II 124-345 1.7e-06 23.3 In-house 2-137 (152) alignment 
Range on Protein: 124-345
Range on HMM: 2-137/152.0
VDGYSKKSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQKRKAPYDIsdrgfeksflhefgaksleecelkakicrkfwpekrskkdfptls
.||| .. ..| .|.| . ...  ||||. | . . |..  . .|. | | .. |                                             
idgyampfefiatqgpgpntla.dfwrmlkelgittivmltellelgklkceqyi.............................................

iqasddhsethmktfnltvtekkqdhqtvLMHFYEWADASKLPEYMLDMRASIKLQYIRSSKKtgvciGPIMLVCATGVEKCAISATIDIIVsriteeHR
                               ... | | .  .  .| . . . .. .. .|.     ||.   |  ||   .  . ....       ..
.............................qylhlpwpDhgvpdlsqlllflllfieklaldkg.....gpvlVHCsaGvgRtgtlvaaylml......lg

VGFKETMSAIKMQRFGCFRTVG
| ..|... ....| | . . |
vsleeavalvrekRpgavpnpg
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 203-341 1.7e-06 22.4 In-house 84-222 (237) alignment 
Range on Protein: 203-341
Range on HMM: 84-222/237.0
AKICRKFWPEKRSKKDFP--TLSIQASDDHSETHMKTFNLTVTEKKQDHQTVL-MHFYEWADAsKLPEYMLDMRAsIKLQYIRSSKKTGvCIGPIMLVCA
 . | |.||.    . .   |.|..  .. |.  .... |..  .... . .   .|  | |   .|..   .   .. . |  |..     || .. |.
elkchkywpstdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdr.gvpqqtaallr.frkniinrsphvs.esgpwiihcs

TGVEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCF
.|| . .|   || .. .  |.. |   . . .|. .|    
agvgrtgiflvidamlrqakekkvvdiynyvysieedrpyii
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 84-173 1.9e-06 21.7 In-house 32-122 (281) alignment 
Range on Protein: 84-173
Range on HMM: 32-122/281.0
YDKFLNNmDMNRIPHLYCFDHSRVELA---PQDGKDDFYNASWVDGYSKKSAYIFAQAPFNdHTEYIFWRMVSERKPSMILVFGDIDEKQKRK
... .||   ||   . |.| |||.|    |.    |.  | ..     |  ||..| | .  |   ||||. . . . |... .. | .. |
fnqpvnn.kknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkk.etradfwrmiwqenttaivmlcqfletnrek
subfamily_PTPN13_pd Subfamily PTPN13 86-171 2.3e-06 22.1 In-house 33-116 (273) alignment 
Range on Protein: 86-171
Range on HMM: 33-116/273.0
KFLNNMDMNRIPHLYCFDHSRVELAPQDGkddFYNASWVDGYSK--KSAYIFAQAPFNDHTEyIFWRMVSERKPSMILVFGDIDEKQK
|  .|.| ||  ..  .|..||.|  . |   . |||..       .  || .| |. . ..  ||.|| |.| ..| .     ||.|
kkkenkdknryrnvlPydetrvklgdegg...yinaslikvpvgkdeyeyiacqGPlPetvk.dfwqmvweqkaeviamvtlekekgk
subfamily_ptpA1_pd Subfamily ptpA1 89-169 3.7e-06 20.9 In-house 46-126 (418) alignment 
Range on Protein: 89-169
Range on HMM: 46-126/418.0
NNMDMNRIPHLYCFDHSRVELAPQDGK--DDFYNASWVDGYSKKsAYIFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEK
 |   ||   .   .|.||.|   . |   |. || ..||   |  .| .| |. . |   ||||| | .  .|...    |.
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpn.tiadfwrmvwenrcriivmlsresen
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 129-316 4.1e-06 21.1 In-house 33-173 (255) alignment 
Range on Protein: 129-316
Range on HMM: 33-173/255.0
KKSAYIFaqapfndhTEYIFWRMVSERKPSMILVFGDIDEkqkrkapydisdrgfeksflhefgaksleecELKAKICRKFWPEKRSKKDFPTLSIQASD
.|. |..        |   |....   |.. . ...|  |                               | . |  . |  ||  |. .  ... ...
rknlysl........tvdkfyqtivqtktevvvmlcdfae...............................egvekcssyfplekdeklkladvnvtttk

DHSETHMKTFNLTVTEK-KQDHQTVLMHFYEWADASKLPEYMLDMRASIKLqyIRSSKktgvcigPIMLVCATGVEKCAISATIDIIVS
  ..  ..| ..| |   |.  .||  ..|.   . . ||   ...  .|.  .| ||       .....|.||. ..|  . ....  
ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkv..vrdsk.......svvvhCstGiGrsaafvlaelvyq
0046846 (Phosphotyrosine protein) phosphatases II 119-345 5.2e-06 21.8 In-house 15-160 (176) alignment 
Range on Protein: 119-345
Range on HMM: 15-160/176.0
YNASWVDGYskksAYIFAQAPFnDHTEYIFWRMVSERKPSMILVFGDIDEKQKRKAPYDISDrgFEKSFLhefgaksleecelkakicrkfwpekrskkd
 ||....|.    ..|  |.|   .| . |..|. | . .... . .  |... | |.. ..  .||  .                              
inanlilgs....rpiatqgpl.prtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..............................

fptlsiqasddhsethmktfnltvtekkqdhqtvLMHFYEWADASKLPEYMLDMRASIKLQYIRSSkktgvciGPIMLVCATGVEKCAISATIDIIVSri
                                    ... | | .  .   |.    .  .....        ||.   |  |.   .  . .... .  
..................................qylhlpwpDhgvpdlelllellefirealkeg.......gpvlVHCsaGigRtgtlvaayllel..

teEHRVGFKETMSAIKMQRF-GCFRTVG
  |. .   |... ...||. |.. | .
..ekglsveealalvreqRplgavqtpe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 198-351 5.5e-06 20.7 In-house 104-252 (290) alignment 
Range on Protein: 198-351
Range on HMM: 104-252/290.0
ECELKAK-ICRKFWPEKRS-KKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYE-WADaSKLPEYMLDMRASIklQYIRsSKKTgvcigPI
... . .  | |. ||.   .  |  |...  .   |  ..| .|.|.  .. . ||  . .. | . .. .|  . . . |  |...  .||     |.
ksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnk.lnvqedtktllsli..qkvk.askt.....pv

MLVCATGVEKCAISATIDIIVSRIT-EEHRVGFKETMSAIKMQRFGCFRTVGPYSTAC
.. |  |. . |. |.|..    |   .. | ... ..|.. ||  .. .   .. . 
ivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 93-318 6.5e-06 20.1 In-house 50-289 (350) alignment 
Range on Protein: 93-318
Range on HMM: 50-289/350.0
MNRIPHLYCFDHSRVELA----PQDGK------DDFYNASWVDGY----SKKSAY--IFAQAPFNDhTEYIFWRMVSERKPSMILVFGDIDEKQKRKAPY
 ||   .  ..||||.|     . |.|      .|. ||...       . .. .  | .|||    |   |.... . |  .||   . .| . .|   
knrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlps.tvddfykvillnkvkvilsltsdvelnlekcyr

DISDRGFEKSFLHEfgaKSLEECELKAKICRKFWPEkrSKKDFPtLSIQASDDHSETHMKTfNLTVTEKKQDHQTVL-MHFYEWADASKL--PEYMLDM-
   . ....  ..    .|  |    .. . ..  .   ||...      |||.   . .. .  .|    |   |. ...  | | | |  || .| . 
YWqegsydditvkl...askwenimgindsslysad..vkkeas.dndnisddndlkdnns.ltaitlaasdPyvvyqlqvknWkDlslllnPesilqal

--RASIKLQYIRSSKKTGVCIGPIMLVCATGVEKCAISATIDIIVSRI
  .  .  . .  |        ||.  |. || .  .  |.| ..| .
evkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 202-343 9.5e-06 19.9 In-house 89-225 (239) alignment 
Range on Protein: 202-343
Range on HMM: 89-225/239.0
KAKICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLdmrASIKLQYiRSSKKTGVCIGPIMLVCATG
. | |...||.  ||     .... ..  ..  ..|| ..   . ...     ||  | |   .|.|     | . |.  . .| .     | .. |..|
hkkkchqywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkg.vpqyat...avlglrr.kitkdslpgarpwvihcsag

VEKCAISATIDIIVSRITEEHRVGFKETMSAIKMQRFGCFRT
| .      || .. .  ... |   . . ||. .|    .|
vgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqt
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 202-343 9.6e-06 19.9 In-house 90-226 (239) alignment 
Range on Protein: 202-343
Range on HMM: 90-226/239.0
KAKICRKFWPEKRSKKDFPTLSIQASDDHSETHMKTFNLTVTEKKQDHQTVLMHFYEWADASkLPEYMLdmrASIKLQYiRSSKKTGVCIGPIMLVCATG
. | |...||.  ||     .... ..  ..  ..|| ..   . ...     ||  | |   .|.|     | . |.  . .| .     | .. |..|
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