Gene moa-1 in Caenorhabditis elegans

Synonym: CELE_R155.2, moa-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP128_AA protein Get Run
CeleP128_AA_850-1154 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 859-1167 3.5e-130 428.4 In-house 1-272 (290) alignment 
Range on Protein: 859-1167
Range on HMM: 1-272/290.0
FRRNESTFDFMKffktsyenkvanmqspevSDLVKKHEMDLRVANPLIEKTRVILKGYKKQFNDNFLHANYVTCPDGMRFILMQSPQCEIlepkpakeke
.|..|||....|                  .|.||||||| |...||.|.|||.||||.|.|||...|||.||||.|.|.||.||||..|          
lrskestavllk..................tdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqeki..........

kytemTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETGLfFeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQLTVTHNLM
     |..|||||||||||..||||.||||.|.| |....|.| | .|.||.|..|..||.|||.||||....|.|..|.|.|...|.|....||||.|.
.....tekrnStiekfwwmakqEkvkqvVmlcefeeksantsl.f.aCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsll

SSWTYLNTQKTTISIISLIQYLNkCKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVrLLAIQFK
..|..||.|..|....||||... ....|...|..|||||||...|.|.||||||||||...|.||....|..|||||... ||...||.|| ||||...
kgWnklnvqedtktllsliqkvk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.llaievl

DQFSKEQTE
|||..|.||
dqfaeeete
0040438 (Phosphotyrosine protein) phosphatases II 863-1168 2.1e-51 170.4 In-house 16-289 (317) alignment 
Range on Protein: 863-1168
Range on HMM: 16-289/317.0
EStFDFMKFFKTSYENKVAnmqSPEVSDLVKKHEMDLRVANPLIEKTRVILKGYKKQFNDNFLHANYVTCPD-GMRFILMQSPQceilepkpakekekyt
     ....|.. ...|.    . .|. |.. ....  .  .. . .||.|. ... ..... .|.||..|. ...||..|.|.                
df.talleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl................

emtprrNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETglffenCSKYYPMkvDTELTFKGITVKCTNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSS
      ..|.|.||.|. ...|. .|| ... |..||.      | .|.|.  ...||....||....... .||. |||...  ||. ..||||  . .
......pntvedFwrmvweqgvtvivmLteleelgrek......caqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytg

WTYLNTQKTTISIISLIQYLNKC---KGAPIVIHDHDGISRSATIPASIIGYQKIaETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLaiQF
|.  .. ... ............   .| |...| ..|..|..|. |  . .. . |. | . ........||.|. |. ||. . ..  ..  .|  ..
WpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleql.ekeggvdveeavkelreqRpgavqtpeqyrflydalleyl..kr

KDQFSKEQTEM
|...   .  .
kltlepaselk
DSPc_SM00195 872-1152 5.1e-50 165.6 In-house 6-261 (263) alignment 
Range on Protein: 872-1152
Range on HMM: 6-261/263.0
FKTSYENKVANmqSPEVSDLVKKHEMDLRVANPLIEKTRVILKGYKKQFNDNFLHANYVTCP-DGMRFILMQSPQceilepkpakekekytemtprrNST
|... |..  .  . . ..  |.....     .....|||.||  .|. ......|||....    ..|..| |.                      .||
fekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......................pst

IEKFWWMIRQEKVEQVVMTCDFLERnretglFFENCSKYYPMKVDTELTFKGITVKCTNMVKVD-GIERRTLCITFGDG-VQLTVTHNLMSSWTYLNTQK
.|.||.|. .|||...||.... |.        |.|..|.| . ... ||. |.||...  |..  |..||| .|. .   . .||.  . .|.  ....
vedFWrmvweekvkiivmlteeeen......gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

TTISIISLIQYLNKCKG---APIVIHDHDGISRSATIPASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAVIVRL
.| |...|.....|.|    .|||.| ..|..|..|. .  | ..|..|..  . . ...  .|..|. ...|  ....|  .|...
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 872-1152 5.1e-50 165.6 In-house 6-261 (263) alignment 
Range on Protein: 872-1152
Range on HMM: 6-261/263.0
FKTSYENKVANmqSPEVSDLVKKHEMDLRVANPLIEKTRVILKGYKKQFNDNFLHANYVTCP-DGMRFILMQSPQceilepkpakekekytemtprrNST
|... |..  .  . . ..  |.....     .....|||.||  .|. ......|||....    ..|..| |.                      .||
fekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......................pst

IEKFWWMIRQEKVEQVVMTCDFLERnretglFFENCSKYYPMKVDTELTFKGITVKCTNMVKVD-GIERRTLCITFGDG-VQLTVTHNLMSSWTYLNTQK
.|.||.|. .|||...||.... |.        |.|..|.| . ... ||. |.||...  |..  |..||| .|. .   . .||.  . .|.  ....
vedFWrmvweekvkiivmlteeeen......gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpd

TTISIISLIQYLNKCKG---APIVIHDHDGISRSATIPASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAVIVRL
.| |...|.....|.|    .|||.| ..|..|..|. .  | ..|..|..  . . ...  .|..|. ...|  ....|  .|...
stksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeailey
0036941 (Phosphotyrosine protein) phosphatases II 888-1153 6.7e-46 152.3 In-house 33-277 (297) alignment 
Range on Protein: 888-1153
Range on HMM: 33-277/297.0
VSDLVKKHEMDLRVANPLIEKTRVILkgykKQFNDNFLHANYVTCPD-GMRFILMQSPQCeilepkpakekekytemtprrnSTIEKFWWMIRQEKVEQV
|. |..  |..     .  ..|||.|    .. .... .|.||...| ...||..| |.                       .|.|.||.|. ...|. .
vallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlp......................ntvedFWrmvweqnvtvI

VMTCDFLERNRETglffenCSKYYPMKVDTELTFKGITVKCTNMVK--VDGIERRTLCITF-GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC
|| ... |..||.      | .|.|.... .||....||..... .   |.. .|||..|. |.| ..||||  . .|   ..  .. |....|....|.
vmltelvelgrek......caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

-----KGAPIVIHDHDGISRSATIPASIIGYQKIAE--TSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLL
     .| |...| ..|..||.|. |  . .| . .  . | . . ... ..||.|. |. |.. . ..  ..  ||
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 842-1153 3.2e-45 150.3 In-house 4-289 (297) alignment 
Range on Protein: 842-1153
Range on HMM: 4-289/297.0
LPDAVKYICDRDRRYSDFRRNESTFDFMKFFKTSYENKVANMQSPEVSDLVKKHEMDLRVANPLIEKTRVILKGYKKQ-FNDNFLHANYVTCPD--GMRF
|.||..  ..   .. |.     . ... .... .|. . .  . ... |..  ..   .  .  . .||.||..... ..... .|.||...|  ...|
lrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

ILMQSPQCEilepkpakekekytemtprrnsTIEKFWWMIRQEKVEQVVMTCDFLERNReTglffenCSKYYPMKVDtelTFKGITVKCTNMVKVDGIER
|..| |. |                      |.|.||.|.....|. .|| ... |..| .      | .|.| ...   |....||....  . ||. .
IatqgPlpe......................tvedFwrmvweqgvtvivmLtklvelgr.k......caqywpeegg...tygdftvtllkvehldgytv

RTLCITFgDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC-----KGAPIVIHDHDGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRA
|||..|  .|  .|||| .  .|   ..  .. ............     || |...| ..|..|..|. |  . .. . .. | . . ......||.| 
rtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRp

LAISTPGELSYIDAVIVRLL
 |. ||. . ..  ... ||
gavqtpsqyrflydallell
0050432 (Phosphotyrosine protein) phosphatases II 843-1153 6.5e-45 149.2 In-house 6-299 (308) alignment 
Range on Protein: 843-1153
Range on HMM: 6-299/308.0
PDAVKYICDRDRRYSDFRRNESTFDFMKFFKTSYENKVAN-----------MQSPEVSDLVKKHEMDLRVANPLIEKTRVILkgykkQFNDNFLHANYVT
.. ..... ||. .. .  . |  |..|...  ....  .           . . .|. |.. ...   .  .  ...||.|     . .... .|.||.
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvd

CP---DGMRFILMQSPQceilepkpakekekytemtprrNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETglffenCSKYYPMKVD-TELTFKGITVKC
..     ..||..|.|                       ..|.|.||.|. ...|. .|| ... |..||.      | .|.|.... . |.....||..
gyssklprkfIatqgPl......................pntvedFwrmvweqnvrvIvmLtklvengrek......caqYwplelgggsleygkftvtl

TNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC-KGAPIVIHDHDGISRSATIPASIIGYQKIAETsGAFVLTDVI
... . |.. .|||..|. |||  .||||  . .|   ..   . ..........|. .| |||.| ..|..|..|. |  . .. . .. | . . ...
lseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeav

DYIREHRALAISTPGELSYIDAVIVRLL
 ..||.|. .. ||  . ..  ... .|
kklReqRpgmvqtpeqylflyralleyl
0045450 (Phosphotyrosine protein) phosphatases II 846-1150 1.3e-44 148.5 In-house 3-301 (307) alignment 
Range on Protein: 846-1150
Range on HMM: 3-301/307.0
VKYICDRDRRYSDFRRNESTFDFMKFFKTSYEnKVANMQSP-----EVSDLVKKHEMDLRVANPLIEKTRVILKGYKKQ-FNDNFLHANYVTCP------
..... .|......  .. . ||.  ..  .| |. ... .     ... |.. ...   .  .. . |||.|. ....  .... .|.||..|      
lplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

---DGMRFILMQSPQCEilepkpakekekytemtprrnsTIEKFWWMIRQEKVEQVVMTCDFLERNRETglffenCSKYYPMKvDTELTFKGITVKCTNM
    ...||..|.|. |                      |.|.||.|.....|. .|| ... |..||       | .|.| . ..|||.. .||.....
gydlkrkfIatqgPlpe......................tvedFwrmlweqgvtvivmltelvelgrek......caqywPde.geeltygnftvtllse

VKVDGIERRTLCITF--GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC-----KGAPIVIHDHDGISRSATIPASIIGYQKIAETSGA--FVL
 . ||. .|||..|   |.|  .||||  . .|   .. ... .....|....|.     || |...| ..|..|..|. |  . .. . ..     . |
ehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdl

TDVIDYIREHRALAISTPGELSYIDAVIV
 ......||.|  |. .|. . ..  .. 
leavkllreqRpgavqnpeqyrflyeall
0043336 (Phosphotyrosine protein) phosphatases II 891-1148 2.6e-42 140.6 In-house 42-272 (278) alignment 
Range on Protein: 891-1148
Range on HMM: 42-272/278.0
LVKKHEMDLRVANPLIEKTRVILKGYKKQFNDNFLHANYVTCPD-GMRFILMQSPQCEilepkpakekekytemtprrnsTIEKFWWMIRQEKVEQVVMT
|.. ...   .  .. . .||.|. ... ..... .|.||.... ...||..| |. |                      |.|.||.|.....|. .|| 
lpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......................tvedFwrmvwelgvttivmL

CDFLERNRETglffenCSKYYPmkvDTELTFKGITVKCTNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC---KG
... |..|..      | .|.|   .. ||....||..... . |.. .|||..|  |||  .||||    .|   ..  .. ............   ..
telvelgrvk......caqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsn

APIVIHDHDGISRSATIPASIIGYQKIaETSGAFVLTDVIDYIREHRALAISTPGELSYIDAV
 |...| ..|..|..|. |  . .. . |. | . | ......||.|. |. ||  . ..  .
gpvlVHCsaGvgRTGtfialyllleql.ekeggvdleeavkelreqRpgavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 883-1149 1e-41 138.6 In-house 27-268 (273) alignment 
Range on Protein: 883-1149
Range on HMM: 27-268/273.0
MQSPEVSDLVKKHEMDLRVANPLIEKTRVILkgykKQFNDNFLHANYVTCPD-GMRFILMQSPQceilepkpakekekytemtprrNSTIEKFWWMIRQE
. . .|. |.. ....     .  ...||.|    .. .... .|.||.... ...||..| |                       ..|.|.||.|. ..
lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPl......................pntvedfwrmvweq

KVEQVVMTCDFLERNRETglffenCSKYYPMKVDT-ELTFKGITVKCTNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQY
.|. .|| ... |..||.      | .|.|..... .||.. .||..... . |..  |||..|. |.|  .|||| .. .|   ..  .. |....|..
nvrviVmLtelvelgrek......caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

LNKC-----KGAPIVIHDHDGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYIDAVI
..|.     .. |.|.| ..|..|..|. |  . .. . .. | . . ... ..|..|  .. ||  . ..  ..
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyeal
0040439 (Phosphotyrosine protein) phosphatases II 889-1148 2.6e-41 137.2 In-house 6-241 (249) alignment 
Range on Protein: 889-1148
Range on HMM: 6-241/249.0
SDLVKKHEMDLRVANPLIEKTRVILKGYKKQFNDNFLHANYVTCPD-GMRFILMQSPQCEilepkpakekekytemtprrnsTIEKFWWMIRQEKVEQVV
. |.. ....  .  .  . .||.|. ... | ... .|.|..... ..|||..| |  |                      |.|.||.|....... .|
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe......................tvedfwrmlwelgitviv

MTCDFLERNRETglffenCSKYYPMkvDTELTFKGITVKCTNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC---
| ... |..||.      | .|.|.  ...|.....||..... . |.. .|||..|. .||  .||.|  . .|   .. ... .....|....|.   
mLtslvelgrek......caqywpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkalee

--KGAPIVIHDHDGISRSATIPASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAV
  || |...| ..|..|..|. |  . .. . .. | . | ......|..|  |. .|. . ..  .
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg.vdleeavkllrsqRpgavqnpeqyrflyea
0046845 (Phosphotyrosine protein) phosphatases II 890-1153 1.6e-40 134.7 In-house 24-274 (284) alignment 
Range on Protein: 890-1153
Range on HMM: 24-274/284.0
DLVKKHEMDLRVANPLIEKTRVILKGYKKQ-FNDNFLHANYVTCP------DGMRFILMQSPQceilepkpakekekytemtprrNSTIEKFWWMIRQEK
 |.. ....  .  .  ...||.|| ....  .... .|.||...        ..||..| |                       ..|.|.||.|. ...
llpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl......................pntvedFwrmvweqn

VEQVVMTCDFLERNRETglffenCSKYYPMKvDTELTFKGITVKCTNMVKVDGIERRTLCITFG--DGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYL
|. .|| ... |..||       |..|.|.. .. ||....||..... . |.. .|||..|.   .|  .||||  . ||   ..  .. .........
vrvIVmltelvengrek......caqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlv

NKC-----KGAPIVIHDHDGISRSATIPASIIGYQKIAETSG--AFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLL
...     .| |||.|...|..|..|. |  . .. . ...    . . ... ..||.|  .. |.  . ..  ... .|
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
0051299 (Phosphotyrosine protein) phosphatases II 903-1150 2.1e-40 134.4 In-house 58-283 (288) alignment 
Range on Protein: 903-1150
Range on HMM: 58-283/288.0
NPLIEKTRVILKGYKKQFNDNFLHANYVTC-PDGMRFILMQSPQCeilepkpakekekytemtprrnSTIEKFWWMIRQEKVEQVVMTCDFLERNRETgl
 .  ...||.|. .... .... .|.|... . ...||..| |                        .|.|.||.|. ...|. .|| ... |..||.  
ilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp......................ntvedFWrmvweqnvrvIvmltklvelgrek..

ffenCSKYYPMkvDTELTFKGITVKCTNMVKVDGIERRTLCITF-----GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC---KGAPIVIHDH
    | .|.|.  .. ||.. |||....... |..  |||..|      |||  .||||  . .|   ..  .. ..........|.   .| |.|.| .
....caqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCs

DGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYIDAVIV
.|..|..|. |  . .. . .. | . . ... ..||.|  .. ||  . ..  ...
aGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyeall
0042113 (Phosphotyrosine protein) phosphatases II 900-1145 4e-39 129.9 In-house 15-235 (245) alignment 
Range on Protein: 900-1145
Range on HMM: 15-235/245.0
RVANPLIEKTRVILKGYKKQFNDNFLHANYVTCPD-GMRFILMQSPQCEilepkpakekekytemtprrnsTIEKFWWMIRQEKVEQVVMTCDFLERNRE
 .  .. . |||.|. .. .. ... .|.||....   .||..| |. |                      |.|.||.|....... .|| ... |..|.
ysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe......................tvedfwrmlwelgittivmLteeeelgrv

TglffenCSKYYPMkvDTELTFKGITVKCTNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNK----CKGAPIVIHDH
.      | .|.|.  ...||....||..... . |.. .|||..|  ||. ...|.| .  .|   ..  .. ..........|    ... |...| .
k......caqywpl..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCs

DGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYI
.|..|..|. |  . .. . .. . . | ......|..|  |. ||. . ..
aGvgRtGtfiaaylmleqleke.lgvsleeavkelrsqRpgavqtpsqyrfl
Y_phosphatase Protein-tyrosine phosphatase 905-1150 3.3e-37 123.5 Pfam-A 12-234 (235) alignment 
Range on Protein: 905-1150
Range on HMM: 12-234/235.0
LIEKTRVILKGYKKQFNdnFLHANYV-TCPDGMRFILMQSPQceilepkpakekekytemtprrNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglff
 ..|||| |||.... .  . .|||| . ..  .||. | |                       .||||.||.|. ||||. .|| ..  |..|      
pydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPl......................kstiedFWrmvwqekvkvivmltsleekgr......

ENCSKYYPMKVDTELTFKGITVKCT-NMV-KVDGIERRTLCITFGDGVQ--LTVTHNLMSSWTYLNTQKTTISIISLIQYLNKCK---GAPIVIHDHDGI
|.|..|.| . ...||.. |.|... .   . ...  |.| ..  .. .   .|..  . .|.  ...... |...||. ..| |    .|.|.|  .|.
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

SRSATIPASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAVIV
.|..|. |  |  ... ...  . . ...  .|..|. ....  .. .. ..|.
gRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 905-1150 3.3e-37 123.5 In-house 12-234 (235) alignment 
Range on Protein: 905-1150
Range on HMM: 12-234/235.0
LIEKTRVILKGYKKQFNdnFLHANYV-TCPDGMRFILMQSPQceilepkpakekekytemtprrNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglff
 ..|||| |||.... .  . .|||| . ..  .||. | |                       .||||.||.|. ||||. .|| ..  |..|      
pydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPl......................kstiedFWrmvwqekvkvivmltsleekgr......

ENCSKYYPMKVDTELTFKGITVKCT-NMV-KVDGIERRTLCITFGDGVQ--LTVTHNLMSSWTYLNTQKTTISIISLIQYLNKCK---GAPIVIHDHDGI
|.|..|.| . ...||.. |.|... .   . ...  |.| ..  .. .   .|..  . .|.  ...... |...||. ..| |    .|.|.|  .|.
ekcaqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGv

SRSATIPASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAVIV
.|..|. |  |  ... ...  . . ...  .|..|. ....  .. .. ..|.
gRtgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 904-1152 1.3e-32 108.7 In-house 43-271 (278) alignment 
Range on Protein: 904-1152
Range on HMM: 43-271/278.0
PLIEKTRVIlkgykkqfndNFLHANYVTCPdGMRFILMQSPQCeilepkpakekekytemtprrnSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglff
. .. .||.          ....|.|.... ...||. | |                        ||...|| |....... .|| ....|..||     
lpydhsrVk..........dYINAsyidgy.pkkfIatqgPlp......................stvadfwrmlwelgitvivmltelvelgre.....

eNCSKYYPmKvDTELTFKGITVKCTNMVKVDGIERRTLCITF-----GDGVQLTVTHNLMSSWTYLNTQKTT--ISIISLIQYLNKC-------------
  | .|.|   .  ||....||.....  .| .  ||| .|       |. ...|||  . .|   ..  ..   |...|.......             
.kcaqywp.e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

---KGAPIVIHDHDGISRSATIPASIIGYQKIaetSGAFVLTDVIDYIREHRAL-AISTPGELSYIDAVIVRL
   .| |...| . |..|..|. |  . .. .    | . | ......|..|   |. ... . ..  ....|
lldsggpvlVHCsaGvgRtGtlvaaylmlell...eggvdlleavkelrsqRpglavqnleqyrflyefllel
0037934 (Phosphotyrosine protein) phosphatases II 905-1145 9.1e-30 99.4 In-house 21-234 (243) alignment 
Range on Protein: 905-1145
Range on HMM: 21-234/243.0
LIEKTRVILKGykkqfnDNFLHANYVTCPDgmRFILMQSPQCEilepkpakekekytemtprrnsTIEK----FWWMIRQEKVEQVVMTCDFLERNREtg
. . .||.|.|      .....||......  |.|..| |  |                      |.|     || |. ..... .|| ... |..||  
pydhsrvkleg......sdyinanliyvtp..rliatqgPlpe......................tveddlasfwrmlwelgitvivmltelvElgre..

lffeNCSKYYPmkvDTElTFKGITVKCTNMVKVDGIERRTLCITF--GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNK-----------CKGAP
    .| .|.|   ... |....||.....   |..  |||...    |.....|.| .  .|   ..  .. ...........            .| |
....kcaqywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

IVIHDHDGISRSATIPASIIGYQKIaetsGaFVLTDVIDYIREHRAL-AISTPGELSYI
...| . |..|..|. |  . ....    | . | ......||.|   |. ||. . ..
vlVHCsaGvgRtGtliaaylmllll....g.vdleeavkllreqRpgkavqtpsqyrfl
WSN Domain of unknown function 47-112 9.4e-28 85.9 Pfam-A 2-67 (69) alignment 
Range on Protein: 47-112
Range on HMM: 2-67/69.0
EFKSSLIQMQMISRVTNGIYLQHGLSNGSIKSDDLIPELLHFGTITPTQISAINTDKLSKIVEGIN
|.. .| ....|.|||||||||.||.||||..||.| |||..|.....|. .|..|||........
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 947-1168 3.3e-24 80.4 In-house 23-234 (255) alignment 
Range on Protein: 947-1168
Range on HMM: 23-234/255.0
EILEPKPAK-EKEKYTEmtprrnsTIEKFWWMIRQEKVEQVVMTCDFLErnretgLFFENCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITF
| ..|.  |  |. |.        |..||. .| | | |.||| ||| |         |.||.|.|.. |  | .. ..| .|. .    .  ...  |.
ehvkPekdkkrknlysl.......tvdkfyqtivqtktevvvmlcdfae......egvekcssyfplekdeklkladvnvtttkssadvvlrtleitstl

G-DGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKCKgaPIVIHDHDGISRSATIPASIIGYQ----KIAETS-GAFVLTDVIDYIREHRALAISTP
|      ||.|     |   |. . .  |  ...   . |  ..|.|   || |||.     . ||     . .|. . .    ... .|..|. || ||
gekkkthtvkhysykGWieknaPelareilnilkvvrdsk..svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtP

GELSYIDAVIVRLLaiQFKDQFSKEQTEM
 .|..   ... |.    |... .. .|.
lqlafsilmvldlv..fpkgeleakyqei
subfamily_hpo-7_pd Subfamily hpo-7 947-1168 6.6e-24 79.2 In-house 26-243 (263) alignment 
Range on Protein: 947-1168
Range on HMM: 26-243/263.0
EILEPKP-AKEKEKYTEmtprRNSTIEKFWWMIRQEKVEQVVMTCDFLErnretgLFFENCSKYYPMKVDTELTFKGITVKCTNMVKvDGIER-RTLCIT
| ..|.   | |. |.        ||.||. .|.| | |.||| ||| |         |.||.|.|.. |  . .. ..| .|.... | . . . |  |
ehfkPekdkkrknlysl....lvqtidkfyqtivqtktevvvmLcDfne......egvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellst

FGDGVQ-LTVTHNLMSSWTYLNTQKTTISIISLIQYLNKCKgaPIVIHDHDGISRSATIPASIIGYQ----KIAETS-GAFVLTDVIDYIREHRALAIST
.|.  .  ||.|.    |   |  . ...|. ...   . |  ..|.|   || |||      . ||     . .|| . .    ... .|..|. || |
lgeKkkthtvkhysykgWiekndpelareilnilkvarnsk..slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht

PGELSYIDAVIVRLLAIQ-FKDQFSKEQTEM
|  |..   ... ..  .  |.. . .  |.
PmqLafsilmvLdfvlnnfakgeleakyqei
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 968-1162 4.2e-22 73.2 In-house 106-298 (305) alignment 
Range on Protein: 968-1162
Range on HMM: 106-298/305.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglFfeNCSKYYPMKVDTELTFKG-ITVKC----TNMVKVDGIERRTLCITFGDGVQLTVTHNLMSSWT
. ||..||||. |.||||.|| |  .|  .    .  .|..|.|.     |..|. | |.       | .   |.  .| .|.  . ...| |   . | 
dqtidefwwmviqnkveqivmlcktvelgk....l..kcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewp

YLNTQKTTISIISLIQYLNKCKgAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAIQFKDQFS
        .. . |.  .   |  |||.|   || |. || |     .||||   .  . ...  .|..|| .| .  .  .|  |..  .  ..|....
drgvppckltslellsairgsk.vpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekykekya
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 908-1150 4.6e-22 73.3 In-house 34-261 (270) alignment 
Range on Protein: 908-1150
Range on HMM: 34-261/270.0
KTRVILKGYKKQFNDNFLHANYVTcpdgmrfilmqspqceilepKPAKEKEKYT-EMTPrRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNC
.|||.|.  ... . ... ||||                        .||.||   |.|  ..|...|| || .|||. .||| .. |..|.      .|
atRvrleeleedsataYinAnyvr....................GfdgekkkYiaamgP.lpttlksfwrmiweekvtaivmttgleEkgrk......kC

SKYYPMKVDTELTFKGI--TVKCTNMVKVDGIERRTLCITfGDGVQLTVTHNLMSSWTY---LNTQ---KTTISIISLIQYL----NKC-KGAPIVIHDH
..|.| .........    .|  .. .| .|  .. | ..  .| .  ..|  . .|      ...    .| ....... .    ..  |. |...|. 
erYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

DGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYIDAVIV
.|. |. |. |  |. . . || .   .. .|. .|..|   ...| .  .. ...|
aGvgRtGtlialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 968-1146 1.1e-19 65.3 In-house 100-274 (301) alignment 
Range on Protein: 968-1146
Range on HMM: 100-274/301.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVDTELTFKGITVKCTN--MVKVDGIERRTLCIT--FGDGVQLTVTHNLMSSWTY
..| | || |. | .||..|| . ..|..       | |..|.|.|.  .|  .  ..| .|  ..  . | .||| ..   |.    ||||   |.|| 
kntsedfwamlvqydvekivmlgqkvekle......ekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtd

LNTQKTTISIISLIQYLNKCKgAPIVIHDHDGISRSAT-IPASIIGYQkiAETSGAFVLTDVIDYIREHRALAISTPGELSYID
 .. |. . .  |.. . | .  |||.|  .|| || . | . ..  .   |.    .||. .  .||||  .. |   | .. 
rgvPkshaelfdlmelvkkse.kPivvhcsaGiGrsvafigteylare..veadptieltealkhlrehrwngvqtnsqlywmt
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 956-1148 8.2e-19 62.9 In-house 87-278 (305) alignment 
Range on Protein: 956-1148
Range on HMM: 87-278/305.0
EKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITF--GDGVQLTV
.|.||       ..|.. || .| .|||...|| ..  | ..      . | .|.| ..  .  |  ..|. ..  .. .   | |.|..  .|  . ||
rkkkyivaqgPlkntvadfWrliveekvstivmltklveggk......dkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtv

THNLMSSWTYLNTQKTTISIISLIQYL----NKCKGAPIVIHDHDGISRSATIPASIIGYQKIaETSGAFVLTDVIDYIREHRALAISTPGELSYIDAV
..  . .|      ... |..|||. .    .| || |...|  .|..|. .  |  |  ... .. .   . .|.  .|..|  ...|  .  ..  .
lqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl.kkEevvdvfevlkqlRskrmkmvqtldqYvflhda
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 969-1137 2.5e-18 60.7 In-house 105-267 (290) alignment 
Range on Protein: 969-1137
Range on HMM: 105-267/290.0
STIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVD-GIERRTLCIT-FGDGVQLTVTHNLMSSWTYLNT
.|.  .| |. ||||  .|| |. .|  .        |..||| |    |||  ||| |..  . |  | ..||..    .| .  . |  . ||     
dtvidiwrmvlqekvaaivmlceliedGka......kceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksv

QKTTISIISLIQYLNKCKGaPIVIHDHDGISRSATIPASIIGYQKIAEtSGAFVLTDVIDYIREHRALAIS
 ..|.... ... | |  | |.|.|   || |. |. |  .| | . .   .. | |..  .|. |. .. 
alstlallrtlrilrkasG.pvvvhcsaGiGrtGtfvaievglqilld.Gkeldlldlvralrnsrlnsvq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 964-1161 8.7e-18 59.4 In-house 88-285 (307) alignment 
Range on Protein: 964-1161
Range on HMM: 88-285/307.0
TPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTF--KGITVKCTNMV--K----VDGIERRTLCITFGDGVQlTVTH
   ...|. .|| |. ||||| |.| |. .|  .       .| .|.|..   .|.|  .. |.  .|.   |     | |.  || . .... . |..|
qgplentqysfwamaiqekvesvimlckvielaki......kceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksr.tiqh

NLMSSWTYLNTQKTTISIISLIQYLNKcKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAI
   . |    . .. .. | |..  .  .  |.|.|   |. || || |  .  .|. .      . .... .|..|  || |  .  |.  |..  .  
lqwenwpdrgvpqinltainlleavry.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle

QFKDQF
..|. .
lykety
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 955-1152 1.7e-17 58.2 In-house 88-282 (290) alignment 
Range on Protein: 955-1152
Range on HMM: 88-282/290.0
KEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKvDTELtFKGITVKCTNMVKVDGIERRTLCITFGD--GVQLT
|||..|  .    ..|. .|| .| ||||  .|| ..  | ..      ..| .|.| . ||.  .  ...| .|  ..... .|.| ..  .  | . .
kekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegk......vkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqs

VTHNLMSSWTYLNTQKTTISIISLIQ----YLNKCKGAPIVIHDHDGISRSATIPASIIGYQKiAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAV
||.  ...|      . . .|...|.       |    .||.|  |...|||.  |  .. .| ..| |   . .|.   |  .   . |  .. .|  .
vtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattink.cktegvidvfqvlksqRiqkpgsvqtvqqyqgifqi

IVRL
... 
vlty
subfamily_PTPN12_pd Subfamily PTPN12 968-1157 6.7e-17 56.3 In-house 93-281 (290) alignment 
Range on Protein: 968-1157
Range on HMM: 93-281/290.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVD-GIERRTLCITFGdGVQLTVTHNLMSSWTYLNT
  |.. || || . .|| ||| |  .| ..        | .|.| ....||.|  ..|....  .|| ..  ||| ...  . . .|.     .|   ..
pktlddfWrmiweknveivvmaCrevelgkk......kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgv

QKTTISIISLIQYLNKC---KGAPIVIHDHDGISRSATIPASIIGYQKIAET--SGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAIQF
 ... |...||. ...    . ||.|.|   |. |  || |  . .. . .   .  . . |..  .|..|| .. |    ...   .. |.  ..
PssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkel
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 968-1149 1.6e-16 55.2 In-house 83-264 (274) alignment 
Range on Protein: 968-1149
Range on HMM: 83-264/274.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTEL--TFKGITVKCTNMVKVDGIERRTLCITFGDGvQLTVTHNLMSSWTYLN
 .|.. || || ||.|. .||. .. |.|..       |..|.| . |.|.  ..... .| ...|. .. . |.| .      . .|.| . ..|   .
pntvadfWrmiyqeevqvivmltklkeaneq......kCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhk

TQKTTISIISLIQYLNK------CKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDyIREHRALAISTPGELSYIDAVI
. . . ....|..  ..       | ||.|.|   || |     |  |. ... |..   ||  | . .| .|   . |     .|  ..
sPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcn.lrldrGGmvqtseqyelihral
subfamily_Ptp69D_pd Subfamily Ptp69D 956-1137 5.1e-15 50.4 In-house 89-270 (307) alignment 
Range on Protein: 956-1137
Range on HMM: 89-270/307.0
EKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKvdTELTFKGITVKCTNMVKVDGIERRTLCITFGDG------V
||.|.       ..||. || || . .|. .||  .  | ||.      .|.||.|.   .|  .  | ||. .  | .   .|.| ..  .        
ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrk......kcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgeved

QLTVTHNLMSSWTYLNTQKTTISIISLIQYL---NKCKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTdVIDYIREHRALAIS
.  |.     .|   .  ... ... ||. .   .| . .|||.|   | .||... |  .  |.. .   . .   ..  .|..| | . 
srkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdife.tvkdLrsqRnllvq
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 967-1129 9.7e-15 49.0 In-house 90-241 (281) alignment 
Range on Protein: 967-1129
Range on HMM: 90-241/281.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGdGVQLTVTHNLMSSWTYLNT
.. |   || || ||.   .|| |.||| |||      .|..|.| .    | |  ..|.  .      .    | ...  |    .|| |   |   . 
kketradfwrmiwqenttaivmlcqfletnre......kcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsye.getrlithwlwkewpdwqv

QKTTISIISLIQYLnKCKGAPIVIHDHDGISRSATIPASIIGYQKIAEtsgAFVLTDVIDYIR
 ...  .. ... . ... .| |||   |. || |. |  |  | |      | | |. . . 
pessevmlkilrki.rarstppvihcsagvgrsgtlmaveialqsihs...hftlpdikqivs
0043147 (Phosphotyrosine protein) phosphatases II 924-1144 1.1e-14 50.0 In-house 7-152 (172) alignment 
Range on Protein: 924-1144
Range on HMM: 7-152/172.0
FLHANYVTCPDG-MRFILMQSPqceilepkpakekekytemtprRNSTIEKFWWMIRQEKVEQVVMTCDFlernretglffencskyypmkvdteltfkg
. .|.|. ..   .||| .| |                       ..|...|| |......  .|. ...                              
yinasyldlyyipdrfiatqgp......................lrntladfwrmlkelgithivnltel..............................

itvkctnmvkvdgierrtlcITFGDGVQLTVTHNLMSSWTYLNTQkTTISIISLIQYLNK----CKGAPIVIHDHDGISRSATIPASIIGYqkiaetsGA
                     . ..... .. . |  .|   ... ..  ..........    ..| |...| . |..|..|. |  . .         
....................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lg

FVLTDVIDYIREHRALAISTPGELSY
. | ......||.|  |. .|. . .
lsleeavalvrekRpgavqnpsqyrf
subfamily_PTPN23_pd Subfamily PTPN23 968-1145 1.9e-14 48.1 In-house 93-272 (288) alignment 
Range on Protein: 968-1145
Range on HMM: 93-272/288.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGV-QLTVTHNLMSSWTYLNT
.||.  || |. ..|.. .||  .  |....      ....|.| . .   .|. ..| . .  . .   .|.| ... |     .|.|  . ||. |  
qstlnDFWlmvyeqkssviVmllskeelgkp......kvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGv

QKTTISIISLIQYLNK-------CKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYI
 ..  ... ...  ..          .|.|.|   |. |. ..   .   ... .  |   . .|.  .|| |   ...  .|   
PasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs
subfamily_PTPRD_pd Subfamily PTPRD 968-1160 2.1e-14 48.1 In-house 101-287 (564) alignment 
Range on Protein: 968-1160
Range on HMM: 101-287/564.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKvDtELTFKGITVKCTNMVKVDGIERRTLCITFG-DGVQLTVTHNLMSSWTYLNT
..||| || |. ..... .||     |....       |.||.| | . . |. ..||. .. ...  .| ||. ..   .  . .|..    ||   . 
aetiedFWRmvweqnsstiVmltkleEkgkv......kchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgv

QKTTISIISLIQYL---NKCKGAPIVIHDHDGISRSATIPASIIGYQKIAEtSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAIqFKDQ
 ... |...||.     |...  |||.|   |. |. |  .  .  ..| | ..   .  ..  .|..|   . |.   ..|  .|.  ||  ....
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac.gnte
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 959-1136 2.2e-14 48.1 In-house 93-262 (315) alignment 
Range on Protein: 959-1136
Range on HMM: 93-262/315.0
KYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKvdtELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQLTVTHNlM
.|        .... || .. .|.. ..||  .  |....      .. ||.| |   ....  |||   .  . . .  ||| ..||| ..  |  . .
ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekr......kaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlh.y

SSWTYLNTQKTTISIISLIQY---LNKCKGAPIVIHDHDGISRSATIpasiIGYQKIAETSGAFVLTDVIDYIREHRAL---AI
.||   .  | ||... ||.     .. . ..||.| ..|. |. |     |  . . .   |  . || ..|.  |.    ..
tswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtf....itldavldqaeaenaidvynfitgvrqnrikmv
0041856 (Phosphotyrosine protein) phosphatases II 921-1144 2.7e-14 48.6 In-house 18-162 (182) alignment 
Range on Protein: 921-1144
Range on HMM: 18-162/182.0
NDNFLHANYVTCPDGM-RFILMQSPQCEilepkpakekekytemtprrnsTIEKFWWMIRQEKVEQVVMTCdflernretglffenCSKYYPmkvdtelt
. .. .||.. ..    |||..| |  .                      |...|. |......  .|. .               .  |.|        
dldyInanlylgslpatrfiatqgplls......................tvadflrmlkelgittivnlt...............eelywp........

fkgitvkctnmvkvdgierrtlcitfgDGVQLTVTHNLMSSWTYLNTQKtTISIISLIQYLNKcKGAPIVIHDHDGISRSATIPASIIGYQKiaetsGaF
                           . .. .... |  .|   ..   . .....|.  .. .| |...| . |..|..|. |  . ...     | .
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkkl.....g.v

VLTDVIDYIREHRALAISTPGELSY
 |.......|..|  .. ||  . .
sleeavklvrsrRpgmvitpnqyff
subfamily_PTPN6_pd Subfamily PTPN6 907-1138 3.2e-14 47.6 In-house 67-282 (306) alignment 
Range on Protein: 907-1138
Range on HMM: 67-282/306.0
EKTRVILKgYKKQFNDNFLHANYVT--CPDGmrfilmqspqceilepkpakeKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffe
..||||||  ..  ..... |||..   ..                      ...|       ..|.. || |. ||. . .|||   .||..|      
Dhtrvilk.epsvpgsdyinanyikkevkgs.....................dksyiatqgclettvsdFWrmvwqensrvivmttkevErgke......

NCSKYYPMKVDTELtFKGITVKCTNMVKVDGIERRTLCIT--FGDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNK-------CKGAPIVIHDHDG
 |..|.| . ..|  .  |.|....  . .  . |.| ..    .. . .| .    ||   ...| .  ...... .|.        .  |||.|  .|
kCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaG

ISRSATIPASIIGyQKIAETSGAFVLTD---VIDYIREHRALAIST
| |  |.    |   |. |..|  . .|   .. ..||.|   . |
iGRtGtfiviDil.lkliekkgldadidiqklvksvreqrsglvqt
subfamily_PTPN3_pd Subfamily PTPN3 960-1152 3.2e-14 47.5 In-house 86-274 (280) alignment 
Range on Protein: 960-1152
Range on HMM: 86-274/280.0
YTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMkVDTELTFKGITVKCTNMVKVDGIERRTLCITFGD-GVQLTVTHNLM
|       ..| ..|| |. ..|.. .||  . .|| |        | .|.|   . ||.. ...|||..  .   .  | |...  .   . ....   
yiatqGPlaktatdfWqmvweqksslivmlttlverGrv......kChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqy

SSWTYLNTQKTTISIISLIQYLNKCK---GAPIVIHDHDGISRSATIPASIIGYQkIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRL
 .|.  .  . . ....... ..|..     |.|.|   || |.  . .  .  . . |.. ..   |..  .|. ||  . |..   ..   |...
laWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
PTPc_DSPc_SM00012 1052-1149 4.7e-14 47.8 In-house 1-103 (105) alignment 
Range on Protein: 1052-1149
Range on HMM: 1-103/105.0
TVTHNLMSSWTYLNTQKTTISIISLIQYLNKCKG-----APIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYID
||.|  ...|.  .. ... ||..|.....|.|      .|.|.|...|..|..|. |  | .|.. .... . . ... ..|..|. ...|  . ... 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

AVI
...
ral
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 968-1154 5.1e-14 47.2 In-house 109-291 (298) alignment 
Range on Protein: 968-1154
Range on HMM: 109-291/298.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTelTFKGITVKCTNMVKVDGIERRTLCITFGD-GVQLTVTHNLMSSWTYLNT
..|.| || |. .|... .||  .  | ..       ...||.| .  .  |.  |||.  .  .   .. |.| ..  .   . .| .  ..||.   .
tetvedFWrmvteedigtiVmltnleeldkt......kyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

QKTTISIISLIQYL----NKCKGAPIVIHDHDGISRSATIPAsIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLA
 ... |.. |..      .... .|....  .|. || |  | |      ....    . .|. ..|..|. |. |  . ..|  .. . |.
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfia.idsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 955-1150 5.3e-14 46.9 In-house 83-275 (287) alignment 
Range on Protein: 955-1150
Range on HMM: 83-275/287.0
KEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVDteLTFKGITVKCTNMVKVDGIERRTLCITFG--DGVQLT
||| ..        .|. .|| .| ...|. .|| |.  | ..      | | .|.| .    ...   ... .|  . .|   |.| ..    .| ...
kekkafiiaesPmfntarnfWkliddrnvtaivmlcqekende......evcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqq

VTHNLMSSWTYLN---TQKTTISIIS-LIQYLNKCKGAPIVIHDHDGISRSATIPASIIGYQKiAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAV
|.   . .|       ...| . .|   ..   |   ..||.|  |.. |||.  |  .. .| ..| |.  . .|..  |  .  .. |  .  .|  .
vkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattink.ckteGviDvfqvlksqriqkpgsvqtveqykfindi

IV
..
vl
subfamily_PTPRB_pd Subfamily PTPRB 969-1154 6.3e-14 46.7 In-house 105-286 (293) alignment 
Range on Protein: 969-1154
Range on HMM: 105-286/293.0
STIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDtELTFKGITVKCTNMVKVDGIERRTLCITFgDGVQLTVTHNLMSSWTYLNTQK
.|...|| |. ..|.. .||  . .|. ..       | .|.| . . . ..  |.|. ..  ...    |.| |.  .  . .|..    ||.  .  .
etvddfWrmvwekkssiivmltqlvekgkv......kCeeYWPadee.pvlyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPe

TTISIISLIQYLN-----KCKGAPIVIHDHDGISRSATIPASIIGYQKIAEtSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLA
.| ....... ..     ... .|||.|   |. |. |  |     |.| | .    .. ..  .||.|.| . |  .  .|. ....|| 
ktktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_egg_pd Subfamily egg 967-1162 6.7e-14 46.3 In-house 93-275 (307) alignment 
Range on Protein: 967-1162
Range on HMM: 93-275/307.0
RNsTIEKFWWMIRQEKVEQVVMTCDFLERnretglffENCSKYYPMKVDTELTF--KGITVKCTNM-VKVDGIERRT-LCITFGDGVQLTVTHNlMSSWT
.| | . || |. ||.|. .||     |         |.|  |.|   .  | .   .. ... ..  | | . | | | .  ||  .. . |     . 
kn.tvddfwrmvfqeevqyivmltsrkes........erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehw.qgdvn

YLNTQKTTISIISLIQYLNKckgaPIVIHDHDGISRSATIPASIIGYQKIA-ETSGAFVLTDVIDYIREHRALAISTPgeLSYIdaVIVRLLAIQFKDQF
...   . . .. ... | |    |.|..|..|.|..||. |  |   ..       ...   . ..| .| |.....  | |.   . ||... |.|  
nssdvysplrvlrklrnlsk....pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesv..llyl..fvyrlvlfffrdvi

S
.
g
subfamily_PTPRA_pd Subfamily PTPRA 955-1144 8.2e-14 46.2 In-house 98-286 (330) alignment 
Range on Protein: 955-1144
Range on HMM: 98-286/330.0
KEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMkvDTELTFKGITVKCTNMVKVDGIERRTLCIT-FGDGV----
|||.|.      .. |.| || || . |   .||  .. ||..      | | .|.|   .  .|.  |.|.  ... .  .  | ....  .|.     
kekdkfiaaqGPkeetvedfwrmiweqksativmltelkerke......ekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekk

QLTVTHNLMSSWTYLNTQKTTISIISL---IQYLNKCKGAPIVIHDHDGISRSATIPAsIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSY
.  |.   . ||  .    ..| ...|   .. ||. .. |||.|   |. |. |  . .    .  .. .   . ...  .|  |.  . |     .
srlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfiv.ldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 923-1147 8.9e-14 46.0 In-house 58-260 (283) alignment 
Range on Protein: 923-1147
Range on HMM: 58-260/283.0
NFLHANYVTCpdgmrfilmqspqceilePKPAKEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTEltFKG
... | ...                    |  |...||       . |.  || |. .||.  .||   . | .|.      .||.|.| .   .  .  
dyinavfipv..................sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri......kCsqyWPkrGsed..yGe

ITVKCTNMVKVDGIERRTLCITFGDG--VQLTVTHNLMSSWTYLNTQKTTISI---ISLIQYLNKCKGAPIVIHDHDGISRSATIPASIIGYQKiAETSG
 ||   . .  .   .. | .        .| ..|  .  |.  . |    |.     .|   .. | .|||.|   || |.|.  |     .. | |. 
ftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkd.altes

AFVLTDVIDYIREHRALAISTPGELSYIDA
   .  |.  .||.|  |. | .    .  
vvdvfavvkimreqrmmavqtldqyklvhe
0051429 (Phosphotyrosine protein) phosphatases II 969-1146 1.1e-13 47.0 In-house 33-218 (272) alignment 
Range on Protein: 969-1146
Range on HMM: 33-218/272.0
STIEKFWWMiRQEKVEQVVMTCDFLERNRetglffENCSKYYP----------MKVDTELTFKGITVKCTNMVKVDGIERRTLCITFG--DGVQLTVTHN
 |.. ||.. .....  .|. ..  ||.|      ..|..| |            .... ..  ..|... ..  . .  |.|..|.    |  ..|.| 
ltaadfwrl.kelgiktivdLrseeErgr......lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhl

LMSSWTYLNTQKTTisIISLIQYLNKckGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAF-------VLTDVIDYIREHRALAISTPGELSYID
.. .|   .. . .  ...|...|..  | |...| . |..|..|. | .. .. . ..  .         | ......|..|. |. |.. . .. 
hytdwpdhgvpqea..llellellld..ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 968-1154 1.8e-13 45.3 In-house 94-277 (281) alignment 
Range on Protein: 968-1154
Range on HMM: 94-277/281.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNRetgLffeNCSKYYPmKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQLTVTHNLMSSWTYLNTQ
 .....||.|. ..||...||    .| ..   |    | .|.|   ..||..  .||| |.  .     .|.. ..  .| . .|..    .|      
PaslvafWqmvweqkvsaivmvtreieagk...l...kChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvP

KTTISIISLIQYLNK----CKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLA
.||  ...  . ..|     . ||.|||   |. |. |  |     ......     ...|.  .|..| | . |    ...  .... | 
attkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 868-1151 1.9e-13 44.5 In-house 15-286 (302) alignment 
Range on Protein: 868-1151
Range on HMM: 15-286/302.0
FMKFFKTSYEnKVANMQSPEVSDLVKKHEMDLRVANPlieKTRVILKGykkqFNDNFLHANYVTCpDGMRFILMQSPQCEIlEPKpakEKEKYTEMTPRR
|..... ..| |. .. | .. . . .   .| . .|   ||   |..    |...|. || ..  |....|. | |     | |   ||..   ..|..
fleyverale.klkkktstnlekdiserrkslficep...ktmaklvd....fkndfinanvlkl.deikwimaqGpmdGt.ekk...ekvskkpivpkk

nSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVDTELTFKGITVKCTNMVK-VDG-IERR-----TLCIT---FGDGVQLTVTHNL
 ||.||.| .| | .|  ||  |.| | .       . |..||  ||. ||.|.  |||  .. . ..   ...     |. |.     . |. ||   .
.stlekhwalieqynvaivvqlcsfvedee......kkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

MSSWTYLNTQKTTISIISLIQYLNKCKGApIVIHDHDGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVR
 |.|    . | . . . .... .  | . ...|   |. |. |. |   | |  ..      | .... .|. |  |. .   | |.  .. .
fsawpdhGapkeaytaldilkfcesykkn.vlvhcsaGvGrtGtlvaikyGiqlcskk.kvtdllsivlpvrqcryGavqdeqqliylllcvtk
0044763 (Phosphotyrosine protein) phosphatases II 907-1148 2.2e-13 45.7 In-house 3-166 (178) alignment 
Range on Protein: 907-1148
Range on HMM: 3-166/178.0
EKTRVILKGYKKQFNDNFLHANYVTcpDGmrFILMQSPQceilepkpakekekytemtprrnstiEKFWWMIRQEKVEQVVMTCDFLERNretglfFENC
. |||.|  .   .   ...|....  .|  ..|.. |.                          .... .......  .|. .. ||..      |..|
drtrvllsnleglersdyinaseil..pg..lylgslpp..........................addlellkelgithivnlteelelg......flkc

SKYYPMKVDteltfkgitvkctnmvkvdgierrtlcitfgdgvqLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKCKGAPIVIHDHDGISRSATIPASI
 .|.|.. .                                   ... |  .. ..  .  . .  .. .|. . . || |...| . |..||.|. |  
dpywpeeag...................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaay

IGYQKiaetsgAFVLTDVIDYIREHRAlAISTPGELSYIDAV
. ..        . | ..|...||.|  .. .|| | ..  .
lmkkl......glsleeaielvrerRp.ivpnpgqlrqLyef
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 962-1158 2.4e-13 44.8 In-house 87-276 (288) alignment 
Range on Protein: 962-1158
Range on HMM: 87-276/288.0
EMTPRrNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVDTELTFKGItvkCTNM-VKVDGIERrTLCITFGD----GV-QLTVTH
  .|  |.|||..| |. .. || .|| |..||. .      |.  .|.|.|.  .  .. .   || . .| ..|.. .. ..       |  .  | .
aqaPl.ngtieelWkmllesdveyivmlcellekGk......eksaeyfPsklGekarigrl...ctvvkkkradidk.lvkvsllriskegeekvivki

NLMSSWTYLNTQKTTISIISLIQYLnKCKGAPIVIHDHDGISRSATIPASIIGYQKIAEtSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAI
  .  |      .  .| . |.. | |    |||.| . |. |..|.  ..|  . .   .    .  ..   ||.|  || |     |.  ..   |..
lhlleWdddgvPenylsplrllevl.kslqkPivvhssaGvGrtgtlililialeslrl.ddflgirsllaklreerfkaiqtemqylyvhrcvleelll

QFK
.  
kky
subfamily_PTPN13_pd Subfamily PTPN13 968-1153 4.2e-13 44.2 In-house 87-269 (273) alignment 
Range on Protein: 968-1153
Range on HMM: 87-269/273.0
NSTIEKFWWMIRQEKVEQVVMTCdfleRNRETGLFfeNCSKYYPMKVDTELTFKG-ITVKCTNMVKVDGIERRTLCITFGD-GVQLTVTHNLMSSWTYLN
  |.. || |. . |.| ..|       ..|.|     | .|.| . . .|. .. ..|.  ...| ||   |.| ..  . |    |.|  . .|   .
Petvkdfwqmvweqkaeviamvt....lekekgkv..kchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhg

TQKTTISIISLIQYLNKCKG--APIVIHDHDGISRSATIPAsIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLL
. ... ... ....... .   .|||.|   || || |. . |     . |    | .....  .|| |   . |     ..  .|. .|
vPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlit.idvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 958-1153 4.8e-13 43.8 In-house 90-279 (288) alignment 
Range on Protein: 958-1153
Range on HMM: 90-279/288.0
EKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETglffenCSKYYPMKvDTELTFKGITVKCTNMVKVDGIERRTLCITfGDGVQLTVTHNL
.||        .|...|| .. ..|.. .||  ...|.....      | .|.| . |..  .  .||. ..  ... .  |.| .   .. .|..|.  
kkyiatqgPladtvndfWelvyenktstivmltelveggktk......CeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyq

MSSWTYLNTQKTTISIISLIQYL---NKCKGAPIVIHDHDGISRSATIPASIIGYQKIAEtSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLL
  .|.  .  . .  .. |.. .   |. .  ||..|  .|. |. |  |     ... | .    .....  .|..||| . |     .|  |.. | 
ylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0051082 (Phosphotyrosine protein) phosphatases II 924-1139 1.1e-12 43.3 In-house 5-139 (151) alignment 
Range on Protein: 924-1139
Range on HMM: 5-139/151.0
FLHANYVTCPdgmrFILMQSPqceiLEpkpakekekytemtprrnstieKFWWMIRQEKVEQVVMTCDFLERNrETGLFFENCSkyypmkvdteltfkgi
.....|||      ..... |    |.                       |. .......  .|. ..  ||.     .... .                
yinfsyvtgg....lyrsggp....la......................dflellkelgiktivnlrseeerg.ycpeylpelg................

tvkctnmvkvdgierrtlcitfgdgvqLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKCKGAPIVIHDHDGISRSATIPASIIGYQKiaetsgaFVLTD
                           ..|.|  . .|.  ... .. ........|...|. |...| . |..|..|. | .. ...       . | .
...........................ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vslee

VIDYIREHRALAISTP
.....|..|  .. ..
aleeyrlkrpgvvqpn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 967-1152 1.2e-12 41.7 In-house 95-275 (515) alignment 
Range on Protein: 967-1152
Range on HMM: 95-275/515.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGvQLTVTHNLMSSWTYLNT
 ..... || .. ||.|  ..|  .  | ..       .|.||.| |    . |  | |.   .    |  .|.| .. ||    |||   .  |    .
nkasvddfWrlvlqenvttiamvtklkegdki......kcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGv

QKTTISIISLIQYLNKCKG---APIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLtDVIDYIREHRALAISTPGELSYIDAVIVRL
.| | |.. ||. .   .|    |..||   |. |   . .      ....|    |. ...  ||..|   . |  . ..|  ..   
pkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvf.nfvtnirqkrpylvqtqeqyafiygavled
0049260 (Phosphotyrosine protein) phosphatases II 966-1145 1.9e-12 42.6 In-house 17-142 (152) alignment 
Range on Protein: 966-1145
Range on HMM: 17-142/152.0
RRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETGLFFEncskyypmkvdteltfkgitvkctnmvkvdgierrtlcitfgdgvqlTVTHNLMSSWTYLN
  . |...|| |... ..  .|| ...||....   .                                                 .. |  .   .  .
pgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpwpDhgvpd

TQKTTISIISLIQYLNKCKGAPIVIHDHDGISRSATIPASIIGYqkiaetsGAFVLTDVIDYIREHRALAISTPGELSYI
     . .. .|. |.. || |...| . |..|..|. |  . .         . | ......||.|  |. .|| | ..
lsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_PTPN9_pd Subfamily PTPN9 968-1147 2.1e-12 41.7 In-house 95-284 (297) alignment 
Range on Protein: 968-1147
Range on HMM: 95-284/297.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCIT-FGDGVQLTVTHNLMSSWTYLNT
. |.. || |. ...|  .|||  ..|| |        |..|.| . ..   |  ..|.  .... .  . |.| |.   .. . .|||  . ||    .
kktvsdfWrmvWeqevlvivmttrvvergrl......kcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGv

QKTTISIISLIQYL----------------NKCKGAPIVIHDHDGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYIDA
 ... |.. ...                   ...| |||.|   || |. |  .  |  ... |. |   ..... ..|. || .| ||    .   
PssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleev.gtvdvvetvkllrtqrafsiqtpeqyefcyl
0036282 (Phosphotyrosine protein) phosphatases II 921-1145 3.4e-12 41.9 In-house 6-162 (174) alignment 
Range on Protein: 921-1145
Range on HMM: 6-162/174.0
NDNFLHANYVTCpdgmRFILMQSPQCeilepkpakekekytemtprrnstiekFWWMIRQEKVEQVVMTCDFLERNRETGLFF--Encskyypmkvdtel
| ..|. .|.|     |.|..| | .                           || |....... ||| ..  |....    .  |              
naspldlsyitp....rliagqgpla...........................fwemlkelgittvvmlleekelglykcinywpe..............

tfkgitvkctnmvkvdgierrtlcitFGDGVQLTVTHNLMSSWTYLNTQKTTIsIISLIQYLNKC----KGAPIVIHDHDGISRSATIPASIIGYQKIAe
                          . .    .. . |   |   ..  ..| ...........    .| |...| . |..|..|. |  . .. .  
..........................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.

tSGafvLTDVIDYIREHR---ALAISTPGELSYI
 ..   | |..|..|| |     .. ||. . ..
.es...lvdaldlvrelRlqrpgmvqtpsQyrfl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 968-1152 3.5e-12 40.7 In-house 98-286 (305) alignment 
Range on Protein: 968-1152
Range on HMM: 98-286/305.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVDTELTFK----GITVKCTNMVKVDGIE------RRTLCITFGDGVQ-LTVTHN
. |   ||.|  |.|||.. | |..||.        . |..|.. | . .|.|.     |.||.   |...  .      ..|  .  | | . . ||| 
ektcadfwymclqdkveaifmlcnllekga......kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthy

LMSSWTYLNTQKTTISIISLIQYLNKCKGaPIVIHDHDGISRSATIpaSIIGYQKIAETSGAFV--LTDVIDYIREHRALAISTPGELSYIDAVIVRL
    |       . ..|. |..     || |||.|   || |. ..   .. |      .|  .     ..  ||| |  .| |  .  ..  ||.  
hwidwpdrgvpaadlailellekarpskg.pivvhcsagigrtgsv..vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilny
0049772 (Phosphotyrosine protein) phosphatases II 886-1133 6.7e-12 41.2 In-house 38-255 (314) alignment 
Range on Protein: 886-1133
Range on HMM: 38-255/314.0
PEVSDLVKKHEMDLRVANPLIEkTRVILkGYKKQFNDNFLHANYVTCPdgMRFILMQSpqceilepkpakekekytemtPrRNSTIEKF----------W
  |.||.. .....    .  . .|||| ..   .. .. .|.|| ..  ..|| .|                      | .. |.. |          |
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf..lkfIatqg.....................p.leitvvdfreepvlyyngw

WMI--RQEKVEQVVM---------------------TCDFLERNretglffencskyypmkvdTE---------LtfkgitvkctnmvkvdgierrtLCI
 |.   . .|  .||                      ... ...                    |                                 ..
rmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...................neptaadlellk......................eel

TFGDGVQLTVTHNLMSSWTYlNTQKTTISIISLIQYLNKC-KGAPIVIHDHDGISRSAT-IPASIIGYQKiaetsGaFVLTDVIDYIREHRA
. .. .. .. . |   ..  ... ..  . ......... || |...| ..|..|..| . | .. ..      | . | ......|. | 
ydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll.....g.vsleealedvrlkRp
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 966-1153 9.1e-12 39.4 In-house 95-277 (315) alignment 
Range on Protein: 966-1153
Range on HMM: 95-277/315.0
RRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGvQLTVTHNLMSSWTYLN
  ..... || |. ||||  .||  .  | ..       .| .|.| .      |  | |.  ..    .   | | .  ..  . |||   .  |    
Plkasvddfwrmvlqekvttivmvtkkqegdki......kcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee.srtvtqfqftewPdkG

TQKTTISIISLIQYL---NKCKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLtDVIDYIREHRALAISTPGELSYIDAVIVRLL
..| | |.. ||. .   |. |  ....|   |. |.  . .     ..|..|.   |. ...  .|..|   . |  | ..|  ..   |
vdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvf.nfvknlrakrpylvqteeeyafiydavledl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 955-1153 1.8e-11 38.7 In-house 88-283 (319) alignment 
Range on Protein: 955-1153
Range on HMM: 88-283/319.0
KEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRetgLffeNCSKYYPMKVDTelTFKGITVKCTNMVKVDGIERRTLCITFGDGV--QLT
.|.||.       . ||| || |. .|..  ||| ..  |. .   .   ...||.| .  .  ..  ..|.  .  . .... | |..    .     .
qerekfiatqaPlentiedfWrmvWeeessivvmltklveklk...v...klkkywpeenfe..eyGrlivtleeeeeledyiirklklnkkssevetRe

VTHNLMSSWTYLNTQKTTISIISLIQYLNKCKGA----PIVIHDHDGISRSATIPASIIGYQKIAETsGAFVLTDVIDYIREHRALAISTPGELSYIDAV
|.|    .|.  .  ... |.. |.. ..| .      |||.|  .|. |  |  .  .  ... |  |.  .  ..  .|  | . ...|   ..|  .
vkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkee.gvlDvfstvsrlRtqRnimvqrpeqYkfiyea

IVRLL
..  .
lleav
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 968-1155 3.6e-11 37.7 In-house 62-244 (250) alignment 
Range on Protein: 968-1155
Range on HMM: 62-244/250.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffEnCSKYYPmkVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQ-LTVTHNLMSSWTYLNT
..|||.|| |. .||.. .||  .. | ..      . ...|.|  |..  .. ..||.  .  .   .. |.| ..     .  .| .    .|     
qatiedfWrmvleeksgtivmLtnLkesek......t.yhqywP..vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgv

QKTTISIISLIQYL---N-KCKGAPIVIHDHDGISRSATIPAsIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAI
 ... ... |.. .   . ... ||....   |..|| .  | |    . ....    . .||  .|..|  |. .    ...  .| . |  
PevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafia.idavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0046846 (Phosphotyrosine protein) phosphatases II 967-1148 5.4e-11 38.1 In-house 32-168 (176) alignment 
Range on Protein: 967-1148
Range on HMM: 32-168/176.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETglffenCSKYYPMKVDTELtfkgitvkctnmvkvdgierrtlcitfgdgvqltvtHNLMSSWTYLNT
 ..|...|. |....... ||. ..  | .|        |  |.|   . ..                                    . |   |   ..
lprtladflemlkelgitavvnlteevelgrlk......cpnywpeleklgi....................................qylhlpwpDhgv

QKTtISIISLIQYLNKCK--GAPIVIHDHDGISRSATIPASIigyqkIAETSGAFVLTDVIDYIREHRA-LAISTPGELSYIDAV
      ...|.......   | |...| . ||.|..|. |       . |..  . . ......||.|   |. ||. . ..  .
pdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 960-1151 8e-11 36.6 In-house 95-282 (297) alignment 
Range on Protein: 960-1151
Range on HMM: 95-282/297.0
YTEMTPRrNSTIEKFWWMIRQEKVEQVVMTCDFLERNretglffENCSKYYPMKVDTEltFKGITVKCTNMVKVDGIERRTLCITFGD-GVQLTVTHNLM
 |. .|  ..|.. || |. .|.|  .||  |  ||.       ..| .|.. |  |.  |  ..|. . . .  |  .|.| .| |.  ..  |     
ittqmPm.katvadfWamvldeqvstivmlnddnerd.......kkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqf

SSWTYLNTQK--TTISIISLIQYLNKC----KGAPIVIHDHDGISRSATIPASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAVIVR
 .|   . ..  .. |.. ||. ..|     . .|...|   |. | . . .      .. ..     . ...  .|..|   . |  . ...  ... 
veWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakreke.vdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 953-1136 9e-11 36.3 In-house 70-250 (285) alignment 
Range on Protein: 953-1136
Range on HMM: 70-250/285.0
PAKEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLErnreTGlfFENCSKYYPMKVDTELTFKG--ITVKCTNMVKVDGIERRTLCITFGDG--
| |..  |         |.  || || |||.  |.| | ..|     |   |.|. ||| |.   . |    ||.   .   . |    .| ..  .   
pgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfe....gg..vekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedas

-VQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC--KGAPIVIHDHDGISRSATIPAsiIGYQKIAETSGAFVltDVIDYIREHRALAI
   | . |  .  |    . . .  .| | ....|   |  ||..|   |. |.||.    | |  |       .  ...| .|| ||. .
seplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvg..idyatirimenpni..emldivremramrf
subfamily_PTPRG_pd Subfamily PTPRG 968-1170 1.4e-10 35.0 In-house 101-303 (563) alignment 
Range on Protein: 968-1170
Range on HMM: 101-303/563.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMkvDTELTFKGITVKCTNMVKVDGIERRTLCITF-----GD--GVQLTVTHNLMSS
..|.. || || ...|. .||  .. ||.|.      .|  |.|   |. .|.. ..|. ..  ..     ||| |       ..    ...|..  ...
kdtfddFWrmiWeqnvaiivmitnlvergrr......kcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytk

WTYLNTQKTTISIISLIQ---YLNKCKGAPIVIHDHDGISRSATIPASIIGYQKIAETSgAFVLTDVIDYIREHRALAISTPGELSYIDAVIVRLLAIQf
|   .. . ..  .. ..   . || .  |||.|.. |..|. |  .     ..| . . |  . ...  || .|   . |  .  ..  ... ..| . 
WPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqen.avnvfgflkhiraqRnflvqteEqYiflhdalleaiask.

KDQFSKEQTEMCK
... ..|| |  |
etellaeqveelk
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 967-1142 2.1e-10 35.2 In-house 100-277 (325) alignment 
Range on Protein: 967-1142
Range on HMM: 100-277/325.0
RNSTIEKFWWMIRQEKvEQVVMTCDFLERNRetglffENCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCIT-FGDGVQLTVTHNLMSSWTYLN
  .||. .| .. . .   ||.  . |. .       ..|..|.| ..    || |. ||   . ..     | | .    .|  ..|    . ||  . 
ltatindlWrlvldWr.csvvvvlneldlgk......drcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmG

TQKTTISIISLIQY---LNKCKG------APIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLtDVIDYIREHRALAISTPGEL
.||   ..||..|    ....        .||..|  .|. |. .  .     .|. | |   .. ...  .|..|   . |  . 
vqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdif.gfvkklrkdrpsmvetvdqy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 969-1154 6.1e-10 33.7 In-house 100-281 (318) alignment 
Range on Protein: 969-1154
Range on HMM: 100-281/318.0
STIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKvdTELTFKGITVKCTNMVKVDGIERRTLCITFGDG-VQLTVTHNLMSSWTYLNTQ
 ||| || |. . .   .||  .  || ..       . .|.| |     ... ..|. .. |...    |.. .|  .   . .|    . ||.  .. 
etieDfWrmvWeqnsavivmltqeeergka......kvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvp

KTTISIISLIQYL---N-KCKGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLtDVIDYIREHRALAISTPGELSYIDAVIVRLLA
. . |...|..     . |..  |||.|   |. |  .  |  |  ..|.. .   |. ...  .||.| | . |     .|  |..  ||
esgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvf.qtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 955-1155 5.8e-09 30.1 In-house 82-295 (301) alignment 
Range on Protein: 955-1155
Range on HMM: 82-295/301.0
KEKEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQ----
.||.|.     . ..|.  || .| |||. ..|| ..  |. ..      .| .|.|    .. .|  .||. .|   .     | |...  || .    
sekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtks......kceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyi

---LTVTHNLmSSWTYLN-------------TQKTTISII-SLIQYLNKCKGAPIVIHDHDGISRSATIPASIIGYQKiAETSGAFVLTDVIDYIREHRA
   . |...  |||. |.              ..| . .|   |.  .|  |.|.|.|  |..||| .  .  ||    .   |   . .|.  .|  . 
erkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ.ckaegVVdvfqvtkavrrskp

LAISTPGELSYIDAVIVRLLAI
 |. |    . |  || . |..
gaVtTLeqytsiydvidmylql
subfamily_PTPRK_pd Subfamily PTPRK 957-1147 4.3e-08 27.3 In-house 85-271 (314) alignment 
Range on Protein: 957-1147
Range on HMM: 85-271/314.0
KEKYTEMTPRRNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMkvDTELtFKGITVKCTNMVKVDGIERRTLCITF---GDGVQLTV
 ...       ..|.. || .. .|.   .||  .. |  |       .|.||.|   |||  .. | |.. ..     .  |.. ..    |   . .|
paafivtqgPlqetvkdfWrlvydencasivmltelvevgrv......kClkyWPe..dtev.ygdikvelvetellaelvvrifrveklargqeeirev

THNLMSSWTYLNTQKTTISIISLIQYLNKC---KGAPIVIHDHDGISRSATIPASIIgYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDA
 .    .|.  .. .   ....|.. ..|    .  .||.|   |  |. |  |  |    ..|. |   .  ..  .|...   . |     .|  
rqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi.vldmieregvvdvfnavktlrsrkvnmveteeqykfiyd
subfamily_eak_pd Subfamily eak 967-1123 4.4e-08 26.9 In-house 102-257 (332) alignment 
Range on Protein: 967-1123
Range on HMM: 102-257/332.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNretglfFENCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQlTVTHNLMSSWTYLNT
... .  || |. ..|   .|.  . .| .      .|.  ||.| |   || |  . |.. . || . .| | | .. |.     | |  .  || ...
sedkvfafwqmvleqkspaivqlledvelk......leksdkyfpdktreelkfGildverkefvkrniletrllelskGneth.rvlhykvfGwtettl

QKTTiSIISLIQYLnKCKGAPIVIHDHDGISRSA------TIP--ASIIGYQKIAETSGAFVLTD
 |     ..| . . |  |.. .|  .. . .|       | |  | ||   . .  .|.||. |
pkye.dflalrkvm.kevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvid
subfamily_PTPN1_pd Subfamily PTPN1 968-1151 5.1e-08 27.0 In-house 81-269 (290) alignment 
Range on Protein: 968-1151
Range on HMM: 81-269/290.0
NSTIEKFWWMIRQEKVEQVVMTCDFLERNRetglffENCSKYYPMKVD-TELTFK--GITVKCTNMVKVDGIERRTLCITF-GDGVQLTVTHNLMSSWTY
 .|.. || |. ..|   |||   ..|...        | .|.|.. .  ||...   ..||  .  . .   .|.| ..        ...|    .|. 
pntvdhfWqmvWeqkskavvmlnkvvekeq......ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpd

LNTQKTTISIISLIQYLNKC-----KGAPIVIHDHDGISRSATIP---ASIIGYQKIAETSGaFVLTDVIDYIREHRALAISTPGELSYIDAVIVR
.   ..  . ..... . ..     .  | |||   || || |.    . ..  .|  ..|.   . .|.  .|..|   | |.  | .    |. 
fgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlss.vdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 967-1145 2.5e-07 24.8 In-house 89-269 (287) alignment 
Range on Protein: 967-1145
Range on HMM: 89-269/287.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPMKvDTELTFKGITVKCTNM-VKVDGIERRTLCITFGDGVQLTVTHNL-MSSWTYL
  .|. .|| .. ....  |..    .|  |       .| ||.| . .  .   | .|   .  .|      |.| .   .. .  | ..| . ||   
iaatvrdfwravletrsasvitmtreveearl......kcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdk

NTQKTTISIISLI----QYLNK----CKGAPIVIHDHDGISRSATIPASIIGYQKIaETSGAFVLTDVIDYIREHRALAISTPGELSYI
    |....| ..    |...      .  |.|.||  || || .. | ..  ..  |  |    . |. ..||.||  . ..  | ..
vlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl.edlGrvdvaavvirlreyraalvqavvqlrll
0048076 (Phosphotyrosine protein) phosphatases II 1046-1147 3.9e-07 25.4 In-house 40-137 (145) alignment 
Range on Protein: 1046-1147
Range on HMM: 40-137/145.0
GDGVQLTVTHNLMSSWTYLNTQKTTISIISLIQYLNKC--KGAPIVIHDHDGISRSATIPASIIGYQkiaetSGaFVLTDVIDYIREHRALAISTPGELS
 ...  .... |  .|   ...  .  ...........  .| |...| . |..|..|. |  . ..      | . | ......|..|  |. .|| | 
lellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrpgavpnpgqlr

YIDA
..  
flye
0048179 (Phosphotyrosine protein) phosphatases II 1056-1145 1.7e-06 23.4 In-house 52-137 (144) alignment 
Range on Protein: 1056-1145
Range on HMM: 52-137/144.0
NLMSSWTYLNTQKTTISIISLIQYLNKC--KGAPIVIHDHDGISRSATIPASIIGYqkiaeTSGaFVLTDVIDYIREHRALAISTPGELSYI
 |  .|   ..   .  ...........  .| |...| . |..|..|. |  . .     . | . | ......|..|  |. .|| | ..
ylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavpnpgqlrfL
Snf7 Snf7 225-281 3.6e-06 12.8 Pfam-A 32-88 (171) alignment 
Range on Protein: 225-281
Range on HMM: 32-88/171.0
DKYNDSPMMTKARGFLKEFKNEKVEKANLETVHKNIDSLSSLAEDLKTNQHVIETLH
 |....  . .|. .||. |. . ....|...  |... .. .| .|.|. |.... 
kklakkgnkdrAlllLkqkkryekqldqldgqlanleqvalaienaksnkevlnamk
subfamily_PTPRN_pd Subfamily PTPRN 967-1144 3.9e-06 20.8 In-house 109-283 (297) alignment 
Range on Protein: 967-1144
Range on HMM: 109-283/297.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNretglfFENCSKYYPMKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGDGVQLTVTHNLMSSWTYLNT
 .||. .|| |. .. |  .|. .   | .       ..|..|.| .      .  . .    .   | . |      .      |||     ||.  ..
lastvadfwqmvweqGvvvivnltrleeeg......vkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegv

QKTTISIISLIQYLNKC---KGAPIVIHDHDGISRSATIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSY
  .. |.. . . .||.   . .|||.|  ||  |. .  .  .  ....       ..  ....|. |.  . |  .. .
PasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfef
subfamily_CG7180_pd Subfamily CG7180 966-1149 7.4e-06 19.8 In-house 93-286 (296) alignment 
Range on Protein: 966-1149
Range on HMM: 93-286/296.0
RRNSTIEKFWWMIRQEKVEQVVMTCDFLERNRETGLFFENC--SKYYPMKVDTeLTFKGITVKCTNMVKVDGI-ERRTLCITFGDGVQLTVTHNLMSSWT
 ...|...|| .. .|... ||. ..  . ..    .. |    .| .. |.. .. |  .   . ..|.       |   .  .  . .|..  .  | 
pkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifvei.veekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWe

Y-LNTQKTTISIISLI----QYLNKC----KGAPIVIHDHDGISRSATIPASIIGYQKIaETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVI
   .    | ..| |.    .. .|     . .|.|.. .|| |||    |  .  ... |  . . . . .  .|..|   . .  |  ||  |.
ledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelv.ekeeevdvFeavktlrrsRpqLvenveeYkyiYdvl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 967-1149 8.7e-06 20.1 In-house 54-235 (237) alignment 
Range on Protein: 967-1149
Range on HMM: 54-235/237.0
RNSTIEKFWWMIRQEKVEQVVMTCDFLERNREtglffeNCSKYYPmKVDTELTFKGITVKCTNMVKVDGIERRTLCITFGD---GVQLTVTHnLMSSWTY
 .|. . || |. |||   .||   ..|.|..       | ||.| . |   ..  .||  .   .      |.| ..      .|.|   .  ..||  
lesscddfwqmvwqekcsvivmltgliegnel......kchkywp.stdqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqy.qftswpd

LNTQKTTISIISLI-QYLNKC----KGAPIVIHDHDGISRSAtIPASIIGYQKIAETSGAFVLTDVIDYIREHRALAISTPGELSYIDAVI
    . | ... .  . .|.     . .| .||   |. |.. |   |    . |.      . . .  | | |   | |  .  .|  .|
rgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtg.iflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
DUF4381 Domain of unknown function (DUF4381) 787-823 9.3e-06 12.2 Pfam-A 10-45 (146) alignment 
Range on Protein: 787-823
Range on HMM: 10-45/146.0
APESISLWPyIAIGVIILLAIAGLGIFFGLRWWSKKQ
 ||..|.|| .|.|. .|||.. | ... | .. ...
lPepvswwP.lapgwwlllalllllllvllirllrrr