Gene mtm-1 in Caenorhabditis elegans

Synonym: CELE_Y110A7A.5, mtm-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP129_AA protein Get Run
CeleP129_AA_163-550 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_MTMR1_pd Subfamily MTMR1 160-548 1.2e-185 609.3 In-house 2-388 (389) alignment 
Range on Protein: 160-548
Range on HMM: 2-388/389.0
LMKDGWKIYSAEKEYERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEgkpFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRS
|..||||.|..|.|.||||..|..||.....||.|....|||...|.|.| ..|   ..|| ..||||.|.|||||.|... |.|.|.|||..|.|||||
lkedGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsde...dlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrs

AEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYE--ENYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSIL
.|||..|..|..|||....|||||||..|||. |||||.|||  |.|.|| |.||.||||||||.|||.| ....|.||.| ...||...|||.|...||
kedekylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklil

EGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDGERSPVFVQFCDCLWQIMRQFPW
.|||| | .|.|||.|||.|||||||||||||||||..|||||||||||.|||||||.|||||| ||.||||.|.|| ||||||.||.||.||..||||.
agavkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfpt

AFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDkKCDETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPSLCGLHVWIDYYARSNP
||||..|.||..||.||.|..||||.|||| | |. |..|.|.|.|||| ..|..|.||.... ...||.... ||. |..| .||.| ||
AFefneefLitlldhlysclfGtflfnsekervke.kvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyylrwnp
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 160-547 2e-136 447.3 In-house 11-403 (404) alignment 
Range on Protein: 160-547
Range on HMM: 11-403/404.0
LMKDGWKIYSAEKEYERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGkpfVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRS
 ..|||.||.||.||.||||...  |.  .||.||...||||...|.|.   .|    .||  .||||.|||||||... . ..|.|.|||. |....||
vledgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDee...lkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrs

AEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYEE--NYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDE-KGYYKALDESKWLNHVQSI
 |||. .  |  |... ..|.|||||| .||. |.||| |||.  .| |. . ||||.||| .|.|||.|  |    ... |.... |..|.||.|....
eedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlselessrWldhikll

LEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHgDDNYSDGERSPVFVQFCDCLWQIMRQFP
|||. ..|  ...||.|||.|||||||||.||.||... ||.||||||||||||||||.|||||| .|||.  ...|. ||||.|.|| || .|...|||
legskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq.ttekssdersPiflqFidcvyqltkqfp

WAFEFTQELLICMLDELYACRYGTFLYNSEKIRLkDKKCDETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPS-------LCGLHVWIDYYARSN
  ||| ...|| .||.||.||.|||||.||| |  ...  . |.|.|... .||... ||.. . |...  |.. |       . ....| .|| |..
tsFeFnekflikildalyscrfgtFLydsekeRq.qnnlaketvslWalleankseylnplyilekkeqkenitssessssadikliklWseyylrwr
0040695 (Phosphotyrosine protein) phosphatases II 160-548 7.3e-135 443.4 In-house 3-387 (388) alignment 
Range on Protein: 160-548
Range on HMM: 3-387/388.0
LMKDGWKIYSAEKEYERLGIPNSrLWKEVDINKDYKFSETYPRTFVIPTvswEEGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRS
|...|| .|. ..|..|||.... ||. ...|..|.....||. .|.|.   .  ....|.   |||| ||||||...... |.. |.|||..|....||
lleegwslydilrelkrlglgld.lwrisivNenyelcpsYPallvVPk...sisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrs

AEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYE--ENYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSIL
 |||. |. |.... |.. |||.|.|| .|| .|.|.|||.|  ..| || | ||||.||||||.||..|| |... .|.  ....|.||.||.....||
ledeklleailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldaclnvpdslnllslleesgwldliklil

EGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDGERSPVFVQFCDCLWQIMRQFPW
|.|| .|  .| .. |||.|||||||||.||.|||.. ||.||||.|||.|||||||.|||||| .|.||....... |.||||..| ||.||..||||.
elavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPt

AFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDkKCDETTISFWSYVLENKKKFRNPMFKHGKSNkVINVNPSLCGLHVWIDYYARSNP
||||.. ||. ..|.||.||.||||.|||| ||.  .. | |.|.|||.| .|..|.||.... ..  |. ...|.. |..|..|| | .|
aFeFnerlLlfLadhlyscrfgtFlfnsekerlel.svsertlslwsyllsrkseflnplYdpssle.vllpslsvldlllWleyylrwlp
subfamily_MTMR6_pd Subfamily MTMR6 159-545 2.1e-131 430.8 In-house 13-394 (397) alignment 
Range on Protein: 159-545
Range on HMM: 13-394/397.0
RLMKDGWKIYSAEKEYERLGIPNSRlWKEVDINKDYKFSETYPRTFVIPTVSweeGKPFVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGkR
  ...||| .. ..||.|.|.||.. |...|.||||.  .||||....|. .    |  .     ||||.|.||||.. ... |.| |||||..|.|  |
eekvsGwklldlkaeytrmgvpnek.wtltdlnkdyelcdtyprelyvPksa...tkevlvgsskfrskgrlPvlsylhkeneaaicrcsqplsgfsa.r

SAEDERHLTNIMNANANCRELLILDARPAVNAKLNKAKGGGYE--ENYVNAPLTFLNIHNIHVVRDSLKRLLAALI-PRVDEKGYYKALDESKWLNHVQS
. |||. |  |..||.| . | ..|.|| .||  |||.| |||  .|| |  . |..|.||||.|.||..|| .      . . ....|..|.|| |...
cledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhika

ILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGddNYSDGERSPVFVQFCDCLWQIMRQF
.|. ..     | .|..|||.||||||||||| .||| . ||.|||||.||.||||||| |||||| || |.   . .  | ||.| || .|.||...||
vldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll..dedskevsPiftqflecvwqlleqf

PWAFEFTQELLICMLDELYACRYGTFLYNSEKIRlKDKKCDETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPSLCGLHVWIDYYAR
| |||| .. |. . | .|.|..|||| |.|| | .|.|  | | | |.|.||.|... ||..|. ....|.... . . |..|   |.|
pkafefnerfllelhdhvyscqfGtflgncekdr.rdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwralynr
Myotub-related Myotubularin-like phosphatase domain 151-491 1.1e-130 428.5 Pfam-A 5-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 151-491 1.1e-130 428.5 In-house 5-352 (353) alignment
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 162-545 1.2e-101 332.5 In-house 13-403 (405) alignment 
Range on Protein: 162-545
Range on HMM: 13-403/405.0
KDGWKIYSAEKEYERLGIP----NSR--LWKEVDINKDYKFSETYPRTFVIPTVSWEEGkpfVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGIS
 |||..|  .||| |. |     ||    ||  .|||.||.  .|. ..|. . . .     ..|.  |||| ||| ||| . .. |||||||||. || 
idgwevynqkkeylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkd...lekifsfrskgripslswkdpssnasisrcsqplvgie

GKRSAEDERHLTNIMnANANCRELLILDARPAVNAKLNKAKGGGYEE--NYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEK--------GYYKALD
  |  ||| . ...    |  . | ..|||| .||  | |.| |.|.  || |. | |.|| ||||.| ||..| .|.     .|         ..  ..
rarcpedelycssla.lsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyie

ESKWLNHVQSILEGAVKAVfNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNysDGERSPVFVQFC
|. |. |..|||| |  .  ..    .|.|.||||||||| |.|||. | || ||||| || ||||||| ||||||  |.||   |  . ||||.| || 
etgwishiksileaatfsa.elilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgn..eeerspifqqfl

DCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKIRLKDKkCDETTISFWSYVLENKKKFRNPMFKHGKSNKVINVNPSLCgLHVWIDYYAR
|| .|.. |||  ||||  ||. . |....|.||||| | || |..|.     ||| || |  | .|| || ..    . .     | | | .|   | |
dccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvqdq.vktktisiwsevnlnvnkflnpyynpqdiqsikpklysrc.lelwkacymr
subfamily_MTMR9_pd Subfamily MTMR9 160-545 4.3e-93 304.5 In-house 10-391 (393) alignment 
Range on Protein: 160-545
Range on HMM: 10-391/393.0
LMKDGWKIYSAEKEYERLGIpNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGkpfVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRS
 . ||.. .. |.|...|    |  |.  ..||..|  ..|| ....|    .|    .|.  .||.. |.||||.....| | . |.|||..| |||| 
iledgysafdrenefaklis.asdewRissvNknfkvcasypesvivPkaiddee...lkasaafreggrfPvLsylhketkavllrssqplcgssgkrc

AEDERHLTNIMNANancRELLILDARPAVNAKLNKAKGGGY--EENYVNAPLTFLNIHNIHVVRDSLKRLLAALIP-RVDEKGYYKALDESKWLNHVQSI
 |||. |  .....   .  ||.| |  . |. ...||||   |..|..   .  ........ ||| .|| |    ... . ... |..|.||..|. .
kedekllnlvlkkl...kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadl

LEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGD-DNYSDGERSPVFVQFCDCLWQIMRQF
|| |....  .|.|...|..| ..| | | |.||||...||...||..||  |||.||   || | .|  .    . .. ...|||. | ||..||..||
leaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqf

PWAFEFTQELLICMLDELYACRYGTFLYNSEKIRlKDKKCDETTISFWSYVLEN--KKKFRNPMFKHgkSNKVINVNPSLCGLHVWIDYYAR
| .||| .||||..  . |....||||...|. | |..| .. |.|.|||| ..   |.| ||....   ..|| ..  .. |..| . | |
pasFEFneelLillfehsyssqfgtflcdneaer.kelklkkktvslwsyvnrpeklkqflnplyea..naeviwpsvapqslelWselylr
subfamily_MTMR3_pd Subfamily MTMR3 275-544 1.6e-92 303.6 In-house 171-440 (442) alignment 
Range on Protein: 275-544
Range on HMM: 171-440/442.0
NCRELLILDARPAVNAKLNKAKGGGYE--ENYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQ
. ..|||.|||    |  |.|||||.|  | | |. ..||.. ||| || |.. | | |    ||. .. ||.. |||...  .|. ||| | .||.|..
ekkkllivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegr

SVLIHCSDGWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDGERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDE
.||.|||||||||.|...|| . || ||||.||| ||.|.|| .||||| .|.|||..    .||.|||.|. |.. |. |||| .|||..  |. ..  
pvlvhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqh

LYACRYGTFLYNSEKIRLKdKKCDETTISFWSYVLENKKKFRNPMFKHGkSNKVINVNPSLCGLHVWIDYYA
 |.| .|||| |||| | . .|. |.|.| ||.. ...|..|| ..|.  ...|. .. |.  |..| . |.
tysclfGtflansekeree.ekvkertlsvWsllrakekeyrnllykek.teavllpavsvrelklwsevyl
subfamily_MTMR5_pd Subfamily MTMR5 293-545 1.1e-54 178.1 In-house 213-480 (483) alignment 
Range on Protein: 293-545
Range on HMM: 213-480/483.0
NKAKGGG-YEENYVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVD----E-KGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTA
.|..  .   | . .| .  .....|  |. |.|.|| | .|  .    | . ..|....| ||. ..|.|. .. .|  .| .. |||.   |||| ||
eksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvta

QLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDgERSPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSE
|..||| . ||.||||.||| ||.|||| .|||.| .|  .   . |    .|||.|| || .|..|||| |||| .  |  .     ..|. |||..||
qvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqss.gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDse

KIRLKD---------KKCDETTISFWSYVLENKKK---FRNPMFKHgKSNKVINVNPSLCGLHVWiDYYAR
. ||.          |. .....| | |. ...|.   | | ...  ....|.  . ..  |.|| |||..
yerlesgllyeekaekrakkagksvwdyidrqhkrspifynflysp.desevlrPssnvsslkvW.dyyle
subfamily_MTMR10_pd Subfamily MTMR10 184-526 4.3e-49 159.3 In-house 25-339 (380) alignment 
Range on Protein: 184-526
Range on HMM: 25-339/380.0
LWKEVDINKDYKFSETYPRTFVIPTVSWEegKPFVKKLGEFRsKERIPVLSWINQTTLASIsRCSQPMTGISGKrSAEDERHLTNIMNANANCrellild
 .. .  |.  .  .|.|. ||.|    .  . . . .  .. . | |...|    . | . |.|.  .  | .  .. |  |  . .....        
aivvllknelfaaaqtlPqyfvvpnslsd..sdverlsrhyk.esRfplwvwshakgaall.rlsalqeaesad.kekeekmlelvrkchpan.......

arpavnaklnkakgggyEENYVNAPLTFLNIHNIHVVRDSLKRLLAALIPR---VDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSD
                 . ..|.   .  .|...    . |..| .   ..     ..... .|....||. |. .|. |..|| .| ..|.||..  |.
.................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqese

GWDRTAQLTSLAMIQLDSYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDDNYSDGErsPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGT
| |    . ||| ..||..||||.||  ||.||| . ||.| .|.||.... .  .  |||. |.|| .| ..||| .||||. .|| ..|  ... ..|
grDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpsekses..pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgiflt

FLYNSEKIRLKDKKCDETTISFWSYVLENKKKFRNPMFKHGKSNKV
|| |||. ||| ..  .  .   |   ||.. . .. ...|   . 
flfnseeqrlkavvsssplliakselkendllkdeldyrqglyaei
subfamily_pats1_pd Subfamily pats1 306-431 2.6e-26 84.2 In-house 335-463 (691) alignment 
Range on Protein: 306-431
Range on HMM: 335-463/691.0
NAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEkQSVLIH-CSDGWDRTAQL---TSLAMIQLDSYYR
 . . ||..   . |..   .|| ...   . .  .| . ||||.. |. .||.|||    .|   .|||..  .|. . . .|   .|||.. .| .||
ssniiflslPtrekveerffdllqsilsldgsddewkeieeskwvdsvkllleaavkvsnlldeG.ssvllknsidsPlieldlasisslaqvlsdPfyr

TIEGFIVLIEKEWCSFGHKFGERIGHGDDN
|..|| ||||||| |.|. | ..  | ...
tldGfkvliekewlsyGfPfskinyhkesd
subfamily_pats1_pd Subfamily pats1 438-524 2e-24 77.9 In-house 553-637 (691) alignment 
Range on Protein: 438-524
Range on HMM: 553-637/691.0
SPVFVQFCDCLWQIMRQFPWAFEFTQELLICMLDELYACRYGTFLYNSEKiRLKDKKCDETTISFWSYVLENKKKFRNPMFKHGkSN
||.|||| | .||. ..||  ||| . ||. ...| .. |.|.|||.  | |  ..|  . . |.||..  || .| | ..||  ..
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseak.rdserkvlkrsksiwsfinqnksrfinllykhs.as
subfamily_MTMR3_pd Subfamily MTMR3 168-274 3.6e-22 71.8 In-house 27-130 (442) alignment 
Range on Protein: 168-274
Range on HMM: 27-130/442.0
YSAEKEYERLGIPNSRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGkpfVKKLGEFRSKERIPVLSWINQTTLASISRCSQPMTGISGKRSAEDERHLT
.. ..|.||||   .  |.  |.|.|.|. ..||.....|..  ..    .||  .||| .|.|.. |  ... | . |||||  |. | |.||||. |.
eklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitddd...lkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllk

NIMNANA
.|..| |
aiakaca
PTPc_DSPc_SM00012 361-469 7.6e-12 40.7 In-house 26-100 (105) alignment 
Range on Protein: 361-469
Range on HMM: 26-100/105.0
VKAVFNVD----TeKQSVLIHCSDGWDRTAQLTSLAMIQLDSYYRTiegfivliekewcsfghkfgerighgddnysdgerspVFVQFCDCLWQIMRQFP
..|| ..     . ...|..|||.|..||.... |...  . ...|                                      .|...........| |
lravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleket.....................................kevdifqivkelrkqRp

WAFEFTQELLICM
..... .. |...
gmvqteeqylfly
subfamily_MTMR5_pd Subfamily MTMR5 171-250 2.1e-09 28.7 In-house 11-93 (483) alignment 
Range on Protein: 171-250
Range on HMM: 11-93/483.0
EKEYERLGIPN------SRLWKEVDINKDYKFSETYPRTFVIPTVSWEEGkpfVKKLGEFRSKERIPVLSWINQTTLASISRCSQP
 ..|.|||. .      .  ..   .||.|. ...||  .|.|.   ..    .....    ..|.||  | .. . | . | ...
vqdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsdds...iarvakcfrqnRlPvvtWrhernkalLiRsggf
subfamily_pats1_pd Subfamily pats1 164-249 9.6e-09 26.1 In-house 5-88 (691) alignment 
Range on Protein: 164-249
Range on HMM: 5-88/691.0
GWKIYSAEKEYERLGIPNSRLWKEVDINkDYKFSETYPRTFVIPTVSWEEgkpFVKKLGEFRsKERIPVLSWINQTTLASISR---CSQ
 ..|||  .|..||..   . |. |..  . . || ||.. ..| .  .|   ...     | . .|||||| ||.  .|. |     |
ifdiyslliegqrlkldldkdwrvvefl.srdlseiyPkrilvPklvsde...llvsyvrkr.sskiPvlswsnqnnksslfricvynq
subfamily_MTMR14_pd Subfamily MTMR14 360-430 3.4e-08 24.7 In-house 259-333 (357) alignment 
Range on Protein: 360-430
Range on HMM: 259-333/357.0
AVKAVfnVDTEKQSVLIHCSDGWDRTAQLTSLAMIQLD------SYYRTIEGFIVLIEKEWCSFGHKFGERIGHGDD
 .| |   . |.. .|.||  |||||   .||  . |          ...|   . .  .|  |||.. .|. .|..
llkyv..kededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgee
0051429 (Phosphotyrosine protein) phosphatases II 349-397 3.4e-06 22.5 In-house 130-176 (272) alignment 
Range on Protein: 349-397
Range on HMM: 130-176/272.0
WLNHVQ--SILEGAVKAVFNvdteKQSVLIHCSDGWDRTAQLTSLAMIQLD
|. |    . |  ..... .    .. ||.||| |.|||. .  | .. |.
wpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvallllllg
0045098 (Phosphotyrosine protein) phosphatases II 350-396 5e-06 21.6 In-house 156-231 (278) alignment 
Range on Protein: 350-396
Range on HMM: 156-231/278.0
LNHVQS---------------ILEGAVKAVFNVDT--------------EKQSVLIHCSDGWDRTAQLTSLAMIQL
..|..                 .  ... . ..                ..  ||.||| |..||. |  . ..  
vthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmle
DSPc Dual specificity phosphatase, catalytic domain 304-390 6.1e-06 21.1 Pfam-A 6-92 (133) alignment 
Range on Protein: 304-390
Range on HMM: 6-92/133.0
YVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTS
. .| |..|....| .| .  |.  ..      |. | .   | .. . ... || ||. . ........||.||  |  |.| |. 
kstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 304-390 6.1e-06 21.1 In-house 6-92 (133) alignment 
Range on Protein: 304-390
Range on HMM: 6-92/133.0
YVNAPLTFLNIHNIHVVRDSLKRLLAALIPRVDEKGYYKALDESKWLNHVQSILEGAVKAVFNVDTEKQSVLIHCSDGWDRTAQLTS
. .| |..|....| .| .  |.  ..      |. | .   | .. . ... || ||. . ........||.||  |  |.| |. 
kstaslalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
0049772 (Phosphotyrosine protein) phosphatases II 356-394 7.7e-06 21.3 In-house 198-235 (314) alignment 
Range on Protein: 356-394
Range on HMM: 198-235/314.0
ILEGAVKAVFNVdTEKQSVLIHCSDGWDRTAQLTSLAMI
... ..... ..  ..  ||.||..|..||. .  .|..
dfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaayl
GRAM GRAM domain 28-90 8.4e-06 16.6 Pfam-A 9-68 (69) alignment 
Range on Protein: 28-90
Range on HMM: 9-68/69.0
LLAAESLIWTeKNVTYFGPLGKFPGKIVITRYRMVFLVGDGGKMYeqWKLDIPLGQVSRIEKV
|.. |.|. .  .... ...|   |.. .| ||..|   .....    ...|||....|.||.
lppeEklldd.yaCylstskgpvqGrlYlTnyrliFrSdklddsk..vvvvipladikrveks