Gene pph-2 in Caenorhabditis elegans

Synonym: CELE_C29E6.3, pph-2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP151_AA protein Get Run
CeleP151_AA_115-394 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 110-401 9.1e-125 410.1 In-house 3-295 (302) alignment 
Range on Protein: 110-401
Range on HMM: 3-295/302.0
KKKEKEKWSGEEASIKFVKSLGSINLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDS
...|||||..||...|.|||| ....|.|...|... |..|.||........|...| ...|.|........|.|.|.||..||..|.||.|.||||.||
veeekekWveeeeakklvksldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvds

VDAVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKaDMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRF
.|.||||||.||.|....|.|....|||.. ....||...||...... .|||.|||||.|..| ...|.|.|||||||.|...||..|.||. ..|...
edsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvky

GAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL--PSGH
...|..|... ||.......|||.|.||.||..|.|||||. ..|..||||.|.|||..||.|||..|||..||||||.|....||.|.  |...
aeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeek
0036941 (Phosphotyrosine protein) phosphatases II 125-398 6e-51 168.9 In-house 5-282 (297) alignment 
Range on Protein: 125-398
Range on HMM: 5-282/297.0
KFVKSLGSINLKDEYDEIQKLPVQTE-RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHE
.. |.|..  |. |..|...| .. . .. ... . ..||. |  .|||.|....  ..||||.| .......  . . | |. .    ||.||| |...
llekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpn...tvedFWrmvweq

QCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKpLFG----PDRFGAQIRAAHQI
.....  . ...||  .  .. .  | | .|. ..|.|....||.....   ....|... |...  .. .. .| |   .|    |. . . |......
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwp.dhgvpespaslldfielvrkv

AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLT---RGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLP
 |. ....|... ...| || ...... .. .||    . ... | |.|...|||||..| .. ||. ||.|  .|.|.||.
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
0040438 (Phosphotyrosine protein) phosphatases II 117-399 2e-49 164.0 In-house 2-282 (317) alignment 
Range on Protein: 117-399
Range on HMM: 2-282/317.0
WSGEEASIKFVKSLGSINLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDA
. ...  ..... ..   |..|. ....|.. | .. ... . ..||. |  .|||.|.... ..    .|||| | ...|.... . . | |.    . 
vldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...pnt

VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQ
|| ||| |........  . ..||| ..  .. . .  | .|. ..|.|.....|.  .|   ....|. . |.|. ... .. .| |     |. .   
vedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdll

IRAAHQIAKN-ENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPS
..  ... .. |....|... ...| || ...... .. .|| ..... . |.|...|||||..| .. ||. ||.| ....|.||..
ldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltl
0050432 (Phosphotyrosine protein) phosphatases II 105-397 3e-49 163.4 In-house 14-303 (308) alignment 
Range on Protein: 105-397
Range on HMM: 14-303/308.0
EKEKPKKKEKEKWSGEEASIKFVKSLGSINLKDEYDEIQKLPVQTE-RCKMWQSHSSRNRHNDSKCYDHNRIIVQmCKDDYINGSKINVP--HFTPSIYL
 .... .....|.| ..   .. | |.. .|. |. |......  | .. ... . ..||. |  .|||.|....  ..|||| | ....  ...  . .
frdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkld.egsdYInAsyvdgyssklprkfIa

VQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESG-AWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYW
 | |.    . || ||| |........  . ...|   .  .. .  | |  .|. ..|.|.....|.  ..   ....|| . |...  .. .. .| |
tqgPl...pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnW

KPLFGPDRFGAQIRAAHQIAKNEnGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
.    |. . . ..  ... |   ...|.|. . .| || .....| .. .|| ..... . |.|...|||||..| .. ||. ||.|  ...|.||
pdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 109-397 3.2e-47 156.8 In-house 8-293 (297) alignment 
Range on Protein: 109-397
Range on HMM: 8-293/297.0
PKKKEKEKWSGEEASIKFVKSLGSINLKDEYDEIQKLPVQtERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKD-----DYINGSKINVPHF-TPSIYLV
 .. . ...| ... ... | ...  |. |. |...|..   .. ... . ..||. |  .|||.|........     |||| | ...... |. ... 
llesipiplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIat

QLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCQESGawlYANGFFVNTRKVEKKENAKADMFVVELlpEGCSnaVMCSVYLHTYWKP
| |  .    || ||| |........  . ...|| .   .. . .|.|   . ..|.|...|||.... .   . |.   .|.|   .. ....| |  
qgPlpe...tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..nges..rtvthfqytgwpd

LFGPDRFGAQIRAAHQIAKNEN---GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
   |. .   ... ... .  .   .. |... ...| || ......  . .|| ..... . |.|...|||||..| .  ||. ||.|  .|.|.||
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 127-393 2.9e-46 153.5 In-house 6-272 (273) alignment 
Range on Protein: 127-393
Range on HMM: 6-272/273.0
VKSLGSINLKDEYDEIQKLPVQTE-RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQC
 |.||.  |. |......|... . .. ... . ..||. |  .|||.|..... ..|||| | ........ . . | |. .    ||.||| |.....
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpn...tvedfwrmvweqnv

QTVHIIARPEELTNPAIDKLFCQESGA-WLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGP---DRFGAQIRAAHQIAK
...  . ...|| ..  .. . .| |  .|. . |.|.....|.  ..   ....|| . |...  .. ....| |     |   . .   |...... .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

NENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
. ..|.|.|. ...| || .....| .. ||| ..... . |.|. .|.||| .| .. ||. ||.|  ...
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0043336 (Phosphotyrosine protein) phosphatases II 116-393 5.8e-46 152.6 In-house 3-277 (278) alignment 
Range on Protein: 116-393
Range on HMM: 3-277/278.0
KWSGEEASIKFVKSLGSINLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvd
.... .  .. ..  .   |. |. |... .. | .. ... . ..||. |  .|||.|.......    .|||| | ........ ... | |  .   
svkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe...

AVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGA
 || ||| |......|.  . ...|| ..  .. .    | .|. ..|.|...|.|.  ..   ... |. . |...  .. .| .. |     |. .  
tvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

QIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
 ..  ... .   . |.|... ...| || .....| .. .|| ..... . |.|...|||||..| .  ||. ||.|  ...
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 134-397 1.1e-43 145.1 In-house 1-278 (284) alignment 
Range on Protein: 134-397
Range on HMM: 1-278/284.0
NLKDEYDEIQKLPVQ---TERCKMWQSHSSRNRHNDSKCYDHNRIIVQM-----CKDDYINGSKINVP-----HFTPSIYLVQLPKMDsvdAVEEFWRVV
.|..|. |...| |    . .. ... . |.||. |  .|||.|.....       .|||| | ....     .... . . | |. .    ||.|||.|
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn...tvedFwrmv

FHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWLYANGFFVNTRKVEKKENAKADMFVVELLpeG-CSNAVMCSVYLHTYWKPLFGP---DRFGAQIRAA
........  . ...|  .   .. . .| | .|. ..|.|.....|.|.. .  .. .. |  | ... ... .. .| |     |   . . . .|..
weqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl..gytgesrtvthfhytswpdhgvppspedlleflrlv

HQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGK---EPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
... .| .|..|.|. . .| || .....| .. .|| ...   .. . |.|. .|||||..| .. ||. .|.|  ...|.||
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
DSPc_SM00195 135-391 2.8e-43 143.5 In-house 2-260 (263) alignment 
Range on Protein: 135-391
Range on HMM: 2-260/263.0
LKDEYDEIQKLPV-QTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVH
|| |......    .. ... ... .|.||... ..|||.|....  .    .|||| . |.... . .. . | |.    . ||.|||.|..|..... 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiiv

IIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKEnAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG-NSP
.. ..||  .  .|. . .|||     . . |....||||. ..  . ..||  ||....  . .| .. |.    ||     ..  ... | ..  ..|
mlteeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

TVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNW
.|. . .| || ....|. .. ..|...|...|.|||. .|.|||..|..  ||  .|.|   
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
PTPc_SM00194 135-391 2.8e-43 143.5 In-house 2-260 (263) alignment 
Range on Protein: 135-391
Range on HMM: 2-260/263.0
LKDEYDEIQKLPV-QTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVH
|| |......    .. ... ... .|.||... ..|||.|....  .    .|||| . |.... . .. . | |.    . ||.|||.|..|..... 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl...pstvedFWrmvweekvkiiv

IIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKEnAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG-NSP
.. ..||  .  .|. . .|||     . . |....||||. ..  . ..||  ||....  . .| .. |.    ||     ..  ... | ..  ..|
mlteeeengkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

TVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNW
.|. . .| || ....|. .. ..|...|...|.|||. .|.|||..|..  ||  .|.|   
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile
0051299 (Phosphotyrosine protein) phosphatases II 122-393 3e-43 143.7 In-house 12-286 (288) alignment 
Range on Protein: 122-393
Range on HMM: 12-286/288.0
ASIKFVKSLGSINLKDEYDEIQKLPVQTE-RCKMWQSHSSRNRHNDSKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEF
  .. ..  |  .|..|..|...| .. . .. ... . ..||. |  .|||.|.....      .|||| | |......    . | |. .    ||.|
klvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn...tvedF

WRVVFHEQCQTVHIIARPEELTNPAIDKLFCQesGAWLYANGFFVNTRKVEKKENAKADMFVVELL--PEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIR
|| |........ .. ...|| .   .. . .  | .|. . ..|.....|.... .   . |. |  ..|...  .. .. .| |     || . . ..
WrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

AAHQIAKN-ENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
  ... |  ..|..|.|. . .| || .....| .. .|| ..... . |.|...|||||..| .  ||. .|.|  ...
flrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 135-395 3e-42 140.8 In-house 29-306 (307) alignment 
Range on Protein: 135-395
Range on HMM: 29-306/307.0
LKDEYDEIQKLPV---QTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK-----DDYINGSKI--------NVPHFTPSIYLVQLPKMDsvdAVEEFWR
|. |. ..... |    . .. ... . ..||. |  .|||.|.... ..     .||||.| .        ......  . . | |. .    ||.|||
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe...tvedFwr

VVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWLYANGFFVNTRKVEKKENAKADMFVVELLpEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQ
 .........  . ...||... ... . .| | .|. . |.|.....|.... .   . |. | .|...  .. .. .| |     |. |   ..  ..
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfiee

IAK--NEN-GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKE---PKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
. |  .|. ...|... .  | || ...... .. .|| ....   . . |.|...|||||..| .. ||. ||.|  .|...
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
Y_phosphatase Protein-tyrosine phosphatase 159-388 2.7e-41 136.9 Pfam-A 2-232 (235) alignment 
Range on Protein: 159-388
Range on HMM: 2-232/235.0
SSRNRHNDSKCYDHNRIIV-QMCK-DDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA
...||..|  .||..|. . . ..  |||| . ..  . . .. . | |  ...   |.|||.|..|..... .... ||  . .... . .|..  |. 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

NGFFVNTRkVEKKENAKADMFVVELLPEGCSNA---VMcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQ
. ..|... ...||. |. .. .  | . ...     . ... .| |.    |.   . ..  ... |.. . ..|.|. . .|.|| . ...| .. .|
gdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|....|... .||...|.|||..|.|. ||. ||.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 159-388 2.7e-41 136.9 In-house 2-232 (235) alignment 
Range on Protein: 159-388
Range on HMM: 2-232/235.0
SSRNRHNDSKCYDHNRIIV-QMCK-DDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA
...||..|  .||..|. . . ..  |||| . ..  . . .. . | |  ...   |.|||.|..|..... .... ||  . .... . .|..  |. 
kkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlksti...edFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

NGFFVNTRkVEKKENAKADMFVVELLPEGCSNA---VMcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVEDQ
. ..|... ...||. |. .. .  | . ...     . ... .| |.    |.   . ..  ... |.. . ..|.|. . .|.|| . ...| .. .|
gdikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|....|... .||...|.|||..|.|. ||. ||.|
leaeeevdvlqivkelRkqRpgmvqsleqYiflyka
0040439 (Phosphotyrosine protein) phosphatases II 151-394 4.6e-38 126.6 In-house 4-247 (249) alignment 
Range on Protein: 151-394
Range on HMM: 4-247/249.0
RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLF
.. ... . ..||. |  .|||.|.... ...    |||| | |....... . . | |  .   .|| ||| .........  . ...|| .   .. .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe...tvedfwrmlwelgitvivmLtslvelgrekcaqyw

CQesGAWLYANGFFVNTRKVEKKENakADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN---GNSPTVIASVNGSGRNAAL
 .  | .|. ..|.|....||.|..    ....|| . .... ... .. .| |     |. |   ..  ... |  .    ..|... . .| || ...
pl..ggsleygdftvtllsvevkdd..ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
...  . .|| . ..  . |.|...|.|||..| .. ||. ||.|  .|..
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 151-393 1.6e-36 121.4 In-house 2-243 (245) alignment 
Range on Protein: 151-393
Range on HMM: 2-243/245.0
RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLF
.. ... . ..||  |  .|||.|....  .    .|||| | ......|| ... | |  .    || ||| .......|.  . ..|||  .  .. .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeeelgrvkcaqyw

CQesGAWLYANGFFVNTRKVEKkeNAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN--GNSPTVIASVNGSGRNAALL
 .  |  |. ..|.|.....|.  ...  ....|. ..|..   .. .|... |     ||     ... . . |  .  .| |... .  | || ....
pl..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

TLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
..  . .|| . ..  . |.|. .|.|||..| .  ||. ||.|  .|.
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 195-418 2.9e-36 118.8 In-house 113-335 (346) alignment 
Range on Protein: 195-418
Range on HMM: 113-335/346.0
FTPSIYLVQLPKMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAiDKLFCQESGAWLYANGFFVNTRKVEKKENAKAdmFVVELLPEGCSNAVMCSV
|   . ..|||.|..   ||.|| ....|| . |...   . | | .   || .| | . |.  .|.| |. .   . |   . .|.|||| |..|.| |
fehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntt.tslfndenggyqytgkmfinnrradvsgdpke..ytievlpegnsdsvicqv

YLHTYWKPLFGPDRFGAQIRAAHQIAKNEN-GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
. |. || |  | .    |.  ||.  ...  |    . |. |.||  ...      .||  | || | ||...|..||| .|.|. || |.|      |
hhhapwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyi

KTKLPSGHEVVS-KIKKFNEKATRSL
  |    .. |  .|..| .. .  .
arkrggkkapvnkdinrfidelaeis
0037934 (Phosphotyrosine protein) phosphatases II 152-393 1.7e-33 111.6 In-house 4-242 (243) alignment 
Range on Protein: 152-393
Range on HMM: 4-242/243.0
CKMWQSHSSRNRHNDSKCYDHNRIIVQMckDDYINGSKINVPhftPSIYLVQLPKMDSVDA-VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqes
. ... . |.||. |  .|||.|....   .||||.. |.|.   | ... |.|  ..|.  ...||| .........  . ...||.    ....    
iallpenlsknrysdilpydhsrvkleg..sdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

GAWlYANGFFVNTRKVEKKENAKADMFVVELLP-EGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAK---------NENGNSPTVIASVNGSGRN
| . . ..|.|.. ..| ... .  ....| |. ....  |.   |... |     || .   ..  ... .         ......|...  . | || 
gev.tygdftvtllseehlddytvrtlllenldlddltrlvi..hyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

AALLTLAVVEDQLtrgkEPKISEIVRTIREQRPQ-SVDSYIQYVSLYMATNWLI
..|... .. ..|    .  . |.|...|||||. .| .. ||. ||.|  .|.
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 149-395 1.8e-25 85.4 In-house 24-274 (278) alignment 
Range on Protein: 149-395
Range on HMM: 24-274/278.0
TERCKMWQSHSSRNRHNDSKCYDHNRIIvqmckdDYINGSKINVPhfTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCq
.  . .. .. ..||  |  .|||.|..      |||| | |...  ..   . | |.    . |. ||| .........  ... .||..   .. .  
eitpalylgnldknRykdilpydhsrVk......dYINAsyidgy..pkkfIatqgPlp...stvadfwrmlwelgitvivmltelvelgrekcaqywp.

EsGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTY-WKPLFGPDRFG---AQIRAAHQIAKNEN--------------GNSPTV
| | .|. ..|.|.. ..|  ..    .. |. |    ..     |. . | . | .|.  .      ...  .| .  .              .. |..
e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

IASVNGSGRNAALLTLAVVEDQLtrGKEPKISEIVRTIREQRPQ-SVDSYIQYVSLYMATNWLIKT
.    | || ..|  .  . ..|  ..   . |.|...|.|||. .| .  ||. ||..  .|.. 
VHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN23_pd Subfamily PTPN23 148-388 4.4e-24 79.8 In-house 33-275 (288) alignment 
Range on Protein: 148-388
Range on HMM: 33-275/288.0
QTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKI-NVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLF
.   . . . .|..||..|   |||||. ..  |||||| | . ..   .|..   | |.  .   . .||..|.... ... ..  .||| .| .|. .
rkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqst...lnDFWlmvyeqkssviVmllskeelgkpkvdrYw

CQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVmCSVyLHTYWKPLFGPD---RFGAQIRAAHQ--IAKNENGNSPTVIASVNGSGRNA
 .. |.    . . |  ..|.. |.    .. .| |..   . | . .   | |  |  |.    . . . ....   |.... . | |.    |.||  
Pedkgetvkfgdlsvtlksvretethvervlkletldadavksv.shl.qltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

ALL-TLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
..    |.|..  ..   . | ..|...||||  .|    |.  .| |
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyea
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 132-390 6.7e-21 69.8 In-house 26-287 (298) alignment 
Range on Protein: 132-390
Range on HMM: 26-287/298.0
SINLKDEYDEIQK----LPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHE
 .....|. ....    .. .. .    ..  ..||. |   .|. |....      . |||| | ..  . ...  . | | .    .||.|||.| .|
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPlt...etvedFWrmvtee

QCQTVHIIARPEELTNPAIDKLFCQEsGAWLYaNGFFVNTRKVEKKENAKADMFVVELLPEGcsNAVMCSVYLHTYWKPLFGPDRFGAQIR--AAHQIAK
. .|. ..   ||| .  . | . .| |.  | . . |. .. |.. .     . |.   |   .  .     .| |     |    . .   .  .  .
digtiVmltnleeldktkyhkywPde.gkety.geitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdkgvpenatsvldllrkvrasq

NENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
...||.| ..   .| ||  .   .  | ... . .   . ..|...|..||..|..  ||| .|.|. 
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 159-389 7.2e-21 69.5 In-house 10-238 (250) alignment 
Range on Protein: 159-389
Range on HMM: 10-238/250.0
SSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPaIDKLFCQESgAWL
  .||. |   .|. |....  |     |||| | ... . . .    | |    ....|.|||.|..|. .|. ...  .|  .  . . .  |  |  
keknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPl...qatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek.aek

YANgFFVNTRKVEKKENAKADMFVveLLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNEN--GNSPTVIASVNGSGRNAALLTLAVVEDQ
| .   |.  . |.. . .   ..  |  .  .. ..   . .. |     |.   | .   ... ....  ||.| ..   .| ||  | ...  | ..
yGd.vtvsllskeefadytkrklk..lskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

LTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
| . |   . ......|..||..|.|  |||..|.. 
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeii
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 123-417 3.3e-20 67.4 In-house 10-306 (318) alignment 
Range on Protein: 123-417
Range on HMM: 10-306/318.0
SIKFVKSLGSINLKDEYDEIQKLPVQTERC-KMWQSHSSRNRHNDSKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFW
 .. ... |...|. ||..... . .. .   . .    .||...   ||| |. .|| ..    |||| . |.  . . .    | |     ...|.||
hvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlp...etieDfW

RVVFHEQCQTVHIIARPEELTNPAIDKLFCQeSGAWLYANgFFVNTRKVEKKENAKADMFVVELlpEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAH
|.|.  ..... .... || .   ... . . .|.  | .   |. ..  . ..     | |.   .....  .   | .| |     |.  .  .    
rmvWeqnsavivmltqeeergkakvhryWPs.kgsrsygk.lvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpesgaslldlvr

QIAKNE--NGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLP--SGHEVVSKIKKFNEK
|. | .  .|..|.|.    | ||    ... .. ...   .   . ..|...||||.  |    ||. .| .    ...  .  . ... |.|....|.
qvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelreq

ATRS
 . |
dpes
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 124-392 3.9e-20 67.1 In-house 14-282 (319) alignment 
Range on Protein: 124-392
Range on HMM: 14-282/319.0
IKFVKSLGSINLKDEYDEIQKLP-VQTERCKMwQSHSSRNRHNDSKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWR
.| ..| |.  |. |. ....   .... ... .  ...||... . ||. |....  ..    |||| | |.  .        | |. .   ..|.|||
lkalastgetllekefkllkeavndtfdsask.eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen...tiedfWr

VVFHEQCQTVHIIARPEELTNPAIDKLFCQESgAWLYaNGFFVNTRKVEKKenakADMFVVELLPEGCSNAV---MCSVYLHTYWKPLFGPDRFGAQIRA
.|..|.. .| ....  |  .  . |.. .|   . |   . |.  . |..    .|. . .|  .  |. |   . . . .| |     |..  . .  
mvWeeessivvmltklveklkvklkkywpeen.feey.Grlivtleeeeel....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

AHQIAKNENG--NSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWL
 ..|.|  ..  . | |.   .|.||  . ..| .. ... .     . ..|...| ||.  |.   ||  .| |    
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_Ptp69D_pd Subfamily Ptp69D 136-389 4.1e-20 67.1 In-house 25-282 (307) alignment 
Range on Protein: 136-389
Range on HMM: 25-282/307.0
KDEYDEIQKLpVQTERCKM--WQSHSSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPkMDSvdAVEEFWRVVFHEQCQTVH
. ||.....       .|.   .    .||..| | .|..|....      . |||| | |.  . . .    | | ...   ...|||..   . ... 
akeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdP.vea..tigDfWRmiaeqevtliv

IIARPEELTNPAIDKLFCQEsGAWLYAnGFFVNTRKVEKKENAKADMFVVELLP-EG--CSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQI-AKNENG
...  .| ..  ..| . .|     |     |.. . ||...     . |     |.    .      | .| ||    |.   . ..  .|.   ... 
mlsnlteknrkkcakYWpie.devqyg.dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln

NSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
.|| |.   .|.|| . ...|... .||   .. .| |.|. .|.||.  |.|. ||| || | 
rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyral
subfamily_PTPN12_pd Subfamily PTPN12 146-399 5.3e-20 66.5 In-house 28-283 (290) alignment 
Range on Protein: 146-399
Range on HMM: 28-283/290.0
PVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPA
 | .  .   ...  .||. |   ||..|. ..  .    .||||.. |. .. . .    | |     .....|||.... . . | .. |  ||    
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLp...ktlddfWrmiweknveivvmaCrevelgkkk

IDKLFCQESGAWLYANGFFVNTrkvEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRN
 .. . .| .  |  . | |..   |.... . |...  |  |  ..  .   . .| |     | ..   ..  ... . .|. ..| |.    | || 
CerYWpeegeeelefgefevtl...eeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrt

AALLTLAVVEDQLTRGKEP---KISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPS
 .....  | ..| ..| |   .. ..|...|.||.  | .  ||. .|.|   |....| .
Gtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkelei
subfamily_PTPRK_pd Subfamily PTPRK 123-388 6.9e-20 66.1 In-house 12-272 (314) alignment 
Range on Protein: 123-388
Range on HMM: 12-272/314.0
SIKFVKSLGSINLKDEYDEIQKLpvqTERCKMwQSHSSRNRHNDSKCYDHNRIIVQMCKDD----YINGSKINVpHFTPSIYLVQLPKMDsvDAVEEFWR
||. .|   .  .|.||. . .     . .|  . . ..|| .|   ||. |....  ..|    |||.. |.  .  |. ..|    ..  . |..|||
siallkraegygfkeeyeslfeg...wdaakk.denreknrsgdilaydrsrvflitidgdpssdyinaalids.ykrpaafivtqgPlq..etvkdfWr

VVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAwlYANgFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQ
.|..|.| .. ...   | ..    | . ...    | . . |.  ..| ...  . .| || |  | ..  .   . .. |     |    . ..  ..
lvydencasivmltelvevgrvkClkyWPedtev..ygd.ikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrr

IAK-NENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
. | .|... ..|.  ..|.||  . .....| | . | .   . ..|.|.|....  |.   ||. .| .
vkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 134-385 1.6e-19 65.0 In-house 7-251 (267) alignment 
Range on Protein: 134-385
Range on HMM: 7-251/267.0
NLKDEYDEIQKLPVQTER--CKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVpHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHII
... |...|.|.  .. .  . . .    ||| .|.  ||..|.|..  ...||| | ..  . |   ..|    ..   .. .|. |. .... .. ..
eiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyveg.yktknafivtqdplk..ntitdfltvihdqkvpvivll

ARpeeLTNPAIDKLFCQESGAWLYANGFFVNtRKVEKKENAkADMFVVELLPEGCSnAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVI
 .        | ...  . |     . . |. . .||.||   .. ..||  .  | |   ..| .  |.       .   . .     . |||| | |.
tk...vftdnirlfwPPkmgqakkyqdltve.hslekeend.yqiitlelkfknes.ahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvv

ASVNGSGRNAALLTlavVEDQLTRGKEPKISEI---VRTIREQRPQSVDSYIQYVSL
|  .| ||  ..|.   .. || | |.  .|.|   .| ||.||.  ||.  .|. .
acsdGvGrsGtflv...idsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_PTPN13_pd Subfamily PTPN13 131-394 2e-19 64.9 In-house 9-270 (273) alignment 
Range on Protein: 131-394
Range on HMM: 9-270/273.0
GSINLKDEYDEIQKLPVQtERCKMWQS--HSSRNRHNDSKCYDHNRIIVQMCKDdYINGSKINVPHfTPSIYLVQLPKMDSVDAVEEFWRVVFHEQCQTV
 . . ..|..|...|  . ..|.. ..  . ..||. .   ||. |....     ||| | |.||      |   . .    ..|..||..|.  ... .
dqqqPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.yinaslikvpv.gkdeyeyiacqGPlPetvkdfwqmvweqkaevi

HIIARPEELTNPAIDKLFCQESGAWLYANG-FFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYlhTYWKPLFGPDRFGAQIRAAHQIAKNENGNS
 ...   |  .   .. . .. .  | ... . |.  ||.|... .   . |. .  | |. |.   .  . |     |      .. . .... .. ..
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnf..vkwPdhgvPssaaellqfvaevrrlqtdag

PTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
| |.    | ||  .|.|. || . . | || ...||||..||||   | .  ||.  | |.  ..|
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPRD_pd Subfamily PTPRD 126-390 5.5e-19 63.2 In-house 16-278 (564) alignment 
Range on Protein: 126-390
Range on HMM: 16-278/564.0
FVKSLGSINLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKD----DYINGSKINVPHfTPSIYLV-QLPKMdsvDAVEEFWRVV
 .|. ...... || .|.. .  | .    .   ..|| ..   |||.|.. .. .     |||| | |.  . ..  |.  | |.    ...|.||| |
klkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPla...etiedFWRmv

FHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWLYaNGFFVNTRKVEKKENAKADMFVVelLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA
. ....|. .. . || ..  ..| . .. |   | ... |.  . |....     | .    .  |.. .   . .| |     |.   . ..  ... 
weqnsstiVmltkleEkgkvkchkYWPek.gtety.geltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvr

K-NENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
. ||... |.|.   .| ||  . ... .. ....  |   | ..|...|.||.  |..  ||. .. | .
alnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheail
subfamily_CG7180_pd Subfamily CG7180 133-387 2.8e-18 60.6 In-house 17-284 (296) alignment 
Range on Protein: 133-387
Range on HMM: 17-284/296.0
INLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVpHFTPSIYLV-QLPKMDsvdAVEEFWRVVFHEQCQT
.  | |.  ...|   . .. . .    .||. .   ||.||....      |.|||| . ..  .  .  |.| . || .   .|.||||.|. |....
veyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvds.flkkkeyivteapkke...tvdefWrlvydeeisa

VHIIARPEELTNpAIDKLFCQESgAWLYANgFFVNTRKVEKKENAKADMFVVELL--------PEGCSNAVMCSVYLHTYWKP-LFGPD---RFGAQIRA
| ..... . ..    . . ..|    | . .||.. ....  | |  .| .            .   .  .. ..  | |.     |     .   .| 
vvvLtktfdfak.mypsywpnks.keqyge.ifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

AHQIAKNE---NGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
.... ..    . ..|.|. | .|..|  . |.. .  ... . .|  . | |.|.|..||| |..  .|  .| 
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYd
subfamily_PTPRA_pd Subfamily PTPRA 136-388 5.9e-18 59.8 In-house 35-290 (330) alignment 
Range on Protein: 136-388
Range on HMM: 35-290/330.0
KDEYDEIQKLPVQTE-RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK----DDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHI
..|.. .   |.|.       .    .||  .   ||..|.|... .     |||| | |.  .   .    | || .   .||.|||...  . .|. .
reefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkee...tvedfwrmiweqksativm

IARPEELTNPAIDKLFCqESGAWLYANgFFVNTRKVEKKENAKADMFVVELLPEGC-SNAVMCSVYLHTYWKPLFG-PDRFGA--QIRAAHQIAKNENGN
..  .|  .    . .  . |.. | |   |. ....  ..     |.|. ||...  ...     .|    | .| |       .. .. .  .. ...
ltelkerkeekcaqywP.deGlvtyGn.irvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

sPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 | |.    | ||  ....|  | ...   .   . |.|. .| |||| | .  ||. .| .
.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykv
PTPc_DSPc_SM00012 292-389 1.1e-17 59.5 In-house 2-103 (105) alignment 
Range on Protein: 292-389
Range on HMM: 2-103/105.0
CSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN---SPTVIASVNGSGRNAALLTLAVVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYM
...| .| |.    |..  . ... ... ||.| .   .|.|. . .| || . . .|... .||... ||..|..||. .|.|||..|... ||. ||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AT
| 
al
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 132-389 1.3e-17 58.8 In-house 20-275 (288) alignment 
Range on Protein: 132-389
Range on HMM: 20-275/288.0
SINLKDEYDEIQKLPVQTERCKMWQSH-SSRNRHNDSKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLVQLPKMDSVdavEEFWRVVFHEQCQ
  ....||. . .|  . . ..  ...  ..||...   ||..|. ..      . |||| | |.. . .      | | .|.|   ..||..|. .. .
rtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtv...ndfWelvyenkts

TVHIIARPEELTNPAIDKLFCQESGAWLYANgFFVNTRKVEKKENAKADMFVVEllpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGN
|.  ..   |  .   .. . ..    .| . . |  ......|.     . .|       . .    | .. |     |.     .   .|.  ... .
tivmltelveggktkCeeYWPdadkpknyGs.vtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

-SPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
  | ..   .| ||    ..|  . |.. . .   . ..|  .|.||.. |.   ||. .| . 
tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevl
subfamily_PTPN3_pd Subfamily PTPN3 129-383 4.1e-17 57.0 In-house 11-265 (280) alignment 
Range on Protein: 129-383
Range on HMM: 11-265/280.0
SLGSINLKDEYDEIQ-KLP-VQTERCKMwQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPS---IYLVQLPKMDsvDAVEEFWRVVFHE
.| | ..  .....  | | .... ...     |.||. |   ||. |....  . |||| . .|.   . .    |..    ..  .....||..|...
glesGavlaqfeqlyrkkpglaisaark.penlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPla..ktatdfWqmvweq

QCQTVHIIARPEELTNPAIDKLFCQESGAWLYAnGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHtyWKPLFGPDRFGAQIRAAHQIAKNE
..... ...   |       . . ...  . |. .| |. .| .....     .|..   .  .. ..   ||   |     ||     ..  ... |  
ksslivmlttlverGrvkChqyWPetedeleyg.efsvkcekedetksyvlrelvlkdketkeerkilqlqyla..WpdhgvPddsadflefvervrklr

NG-NSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYV
.| ..|.|.    | ||   |..| .    . . ..  . .||||.|.||   |..  || 
sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqyk
subfamily_PTPRB_pd Subfamily PTPRB 131-394 8.1e-17 56.2 In-house 23-286 (293) alignment 
Range on Protein: 131-394
Range on HMM: 23-286/293.0
GSINLKDEYDEIQKLPV-QTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQC
  .....||.|....   |.  .   .  ...||...   |||.|. ..      ..|||| . |.  . .      | |  ..   |..|||.|. ...
sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpet...vddfWrmvwekks

QTVHIIARPEELTNPAIDKLFCQESGAWLYANgFFVNTRKVEKKENAKADMFVVELlpegCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA---KN
... .. .  |      .. . ... . || .   |.  . |..|.     . .|      ..      | .| |     |..  . ..  ...    ..
siivmltqlvekgkvkCeeYWPadeepvlyGd.ikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

ENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
.. ..|.|.    | ||  ....|  . .....     |  ||  .||.| . | .  ||. .. .   |..
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 136-388 2.7e-16 54.3 In-house 22-272 (315) alignment 
Range on Protein: 136-388
Range on HMM: 22-272/315.0
KDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHII
 .|. ..   ..  .|    .   ..||...   .|..|...    .  ..|||| |.|.  .   .    | |.  |||   .|||.|..|.  |. ..
seefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvd...dfwrmvlqekvttivmv

ARPEEltNpaiDKLFCQESGAWLYANGFFVNTRKVEKKE-NAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPT
.  .|  .   ||. |.       |.     . |||  . .| .|. . .|      .    . .  | |     . . .. ..  ...   |.. . . 
tkkqe..g...dkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsl

VIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
..  . | ||   ....  | .|. |..   . ..|...|..||. | .  .|  .| |
lvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiyda
subfamily_PTPN9_pd Subfamily PTPN9 124-388 3.8e-16 54.0 In-house 7-285 (297) alignment 
Range on Protein: 124-388
Range on HMM: 7-285/297.0
IKFVKSLGSINLKDEYDEIQKLPVQ-TERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWR
...||. |   |. || ||.. ||. |  . . .. ...||..|  |||. |. ..  ..    |||| . ..  .   ..   | |      .|..|||
vayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk...tvsdfWr

VVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCsvYLHTYWkPLFGPDRFG-------A
.|. ... .. ...| .|       . . .|...      . |.. .||..|. |  .....   .. |  |.   .  . | | .|  . .        
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvth..fqflsW.PdyGvPssaaslldvle

QIRA-----AHQIAKNENG---NSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
..|      .........|   . | |.    | ||  .. || .  ..| .    .. | |...|.||  |.    ||.  |.|
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcyla
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 130-386 1.1e-15 52.4 In-house 13-270 (307) alignment 
Range on Protein: 130-386
Range on HMM: 13-270/307.0
LGSINLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQM--CKDDYINGSKINVPHFTPSIYLVQLPKmDSvdAVEEFWRVVFHEQCQT
 |  .|.||. .. |   ..   . ... . .||..| || |..||.|..     |||    . .      .   | |. ..  .. .|| ..  |. ..
kgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgpl.en..tqysfwamaiqekves

VHIIARPEELTNPAIDKLFCQESGAWL-YA-NGFFVNTRKVEKKENAKADMFVvELLPEGCSNAVMCSVYLHTYWKPLfgPDRFGAQI--RAAHQIAKNE
| ....  ||..   .. .  | |  | .. ..  ..  ..  |. |  . .. ..       |  .    |  |.    |||   ||   |   .   .
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenw..pdrgvpqinltainlleavr

NGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPK-ISEIVRTIREQRPQSVDSYIQYVSLY
  . | |.    | ||  .......| |.. .|.. | . ..|. .|.||. .. . .||. |.
ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylh
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 145-386 6.3e-15 49.6 In-house 41-276 (290) alignment 
Range on Protein: 145-386
Range on HMM: 41-276/290.0
LPVQTERCKMWQSHS--SRNRHNDSKCYDHNRIIVQMCK-DDYINGSKINvpHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPA
||||    |...  .   .||. |  | |  |.|..     ||.    ..     . . | | .  |   .| ..||.| .|.  .. ..    |  .. 
lpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvk..GlkamfiltqGalkd...tvidiwrmvlqekvaaivmlceliedGkak

IDKLFCQESGAWLYANGFFV-NTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAKNengNSPTVIASVNGSGRN
 .. . ...|  |    . |  . . .| .| .  .. |    .| .  .    .    |     .    | .|  . . |    . | |.    | || 
ceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklk..hlkikswpdksvalstlallrtlrilrka...sGpvvvhcsaGiGrt

AALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
 .. .. |  . |. ||| .. ..||..|. | .||.  |||. | 
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 158-390 8.5e-15 49.6 In-house 51-281 (297) alignment 
Range on Protein: 158-390
Range on HMM: 51-281/297.0
HSSRNRHNDSKCYDHNRIIVQMCKDD----YINGSKINVPHFtpSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPEELTNpAIDKLFCqESGAW
  ...|....  || .|.....  ||    |.| | ... .    .   | |. ..   |..||..|..|| .|. ...  .| ..    . .  ..|  
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkat...vadfWamvldeqvstivmlnddnerdk.kcaryWs.dkgvt

LYANgFFVNTRKVEKKENAKADMFVVEllPEGCSNAVMCSVYLHTYWKPLFGPD--RFGAQIRAAHQIAKN--ENGNSPTVIASVNGSGRNAALLTLAVV
 . .   | .  |...|      ..|.   .   .  .   | ...|     .   .  . .   ... |.  .| ..| ..  ..| || . |||.  |
tfGd.vsvvllsvsereGfikrelevt..kgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsv

EDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATN
  .  | ||  | ..|. .|..||. |    ||  .| | .
vaeakrekevdifglvkklrqerpylvqtkeqykfvyvavl
subfamily_PTPN14_pd Subfamily PTPN14 129-388 1e-14 49.3 In-house 19-291 (300) alignment 
Range on Protein: 129-388
Range on HMM: 19-291/300.0
SLGSINLKDEYDEIQKLPVQTE-RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKD---DYINGSKINVPHFTPS-IYLVQLPKMdsVDAVEEFWRVVFHE
 | . ..  ||..|.|   ...  .   .   ..||..|   |..||. .. .|.   .||| |.|.|.  . .  |.|    .    .|..||..|. .
kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPl..eltvqdfWqmvWeq

QCQTVHIIARPEELTNPAIDKLFCQE--SGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYlhTYWKPLFGPD------RFGAQIRA
. | . .... ||  .    | | ..  .   .  . | | |. .|. .   .  . .. || .    |.   |  | |     |.       .  ....
gvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqy..tDWpdhgvPeDvkgflsyLeevqs

----AHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
    ...  .... . | ..   .| ||   |..  ..   |  ..| .| ......||||   |..  ||  .| .
vrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkv
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 135-389 1.1e-14 49.5 In-house 36-287 (319) alignment 
Range on Protein: 135-389
Range on HMM: 36-287/319.0
LKDEYDEIQKLPVQTERC--KMWQSHSSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVpHFTPSIYL-VQLPKMdsvDAVEEFWRVVFHEQCQT
|. |.  . ||.|.         .    .||  .   .|.|.. ..        |||| | ..  .  .  |.  | |.    .....|||...  .| |
levefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtG.yqrkdkyiaaqGPld...ntladfWrmiweyncst

VHIIArpeeltnpaidKLFCqeSGAWLYAN-----GFFVNTRKVEKKENakadmFVV---ELLPEGCSNAVMCSVYLHTYWKPLFG-PDRFGAQ---IRA
. ...           |  |  |  |          | |.   ||. ..     .||   ||  .|  . .      |    |  | ||        .. 
ivllt...........kdkc..sqywplkivikeerfkvkvdsveetae.....yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkk

AHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 . . . ||.. . |.    |.||  . ..| |. |.. . |   . ..|| .|.||.. |....||  .|.| 
vrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 158-389 1.9e-14 48.9 In-house 25-251 (284) alignment 
Range on Protein: 158-389
Range on HMM: 25-251/284.0
HSSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVPHfTPSIYL-VQLPKMdsvDAVEEFWRVVFHEQCQTVHIIArpeeltnpaidKLFCqeSGA
   .||  .   .|.|.. ..        |||| | |.     .  |.  | |.    .....|||...  .| |. ...           |  |  |  
nkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPld...ntladfWrmiweyncstivllt...........kdkc..sqy

WLYA-----NGFFVNTRKVEKKENakadmFVV---ELLPEGCSNAVMCSVYLHTYWKPLFG-PDRFGAQ---IRAAHQIAKNENGNSPTVIASVNGSGRN
|        . | |.   ||. |.     .||   ||  .|  . .      |    |  | ||        ..  . . . ||.... |.    |.|| 
wplkivikeerfkvkvdsveesee.....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

AALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 . ..| |. |.. . |   . ..|| .|.||.. |....||  .|.| 
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN6_pd Subfamily PTPN6 128-396 2.2e-14 48.2 In-house 21-300 (306) alignment 
Range on Protein: 128-396
Range on HMM: 21-300/306.0
KSLGSINLKDEYDEIQKLPVQTERCKM---WQSHSSRNRHNDSKCYDHNRIIV---QMCKDDYINGSKINVPHFTP-SIYLVQLPKMdsVDAVEEFWRVV
.||.  ....|..|.|.  ...   ..    ..  ..||.. .  .||.|.|.   ..  .||||.. |.    .    |.     .   . |..|||.|
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgcl..ettvsdFWrmv

FHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKvEKKENAKADMFVVE-LLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQI
. |... . .. .  | ..    . . .|.    | .    |... ..... .   ..|.    ....  |.   | .. |     |   || .   ...
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevf..qyhfksWPdhgvpkdpgavLdfledv

AKNEN-----GNSPTVIASVNGSGRNAALLTLAVVEDQLTRG---KEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTK
 ....      . |.|.   .| ||  ... . .. .....     .  | ..|...|||| . |    ||  .|.| .  |.||
nrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 130-395 4.9e-14 47.2 In-house 19-285 (305) alignment 
Range on Protein: 130-395
Range on HMM: 19-285/305.0
LGSINLKDEYDEIQKLpVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCK--D--DYINGSKINVPHFTPSIYLVQLPkMDsvDAVEEFWRVVFHEQC
  . .|. .|......  ..   .  . . ..||...   .|..|||..  .  |  |||| | ..  .   .  . | | ..  . |..|||....|. 
ysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgP.lk..ntvadfWrliveekv

QTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELlPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG
.|. ....  |  .    . . .. .     . | |. .  .. ..     . .    .. ..    . |  | |     |.  .. ..  ... |. . 
stivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisi.ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

N--SPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
.   | ..   .| ||  . ... .  ..| . ..  . |.....|..|.. | .  |||.|. | . ||..
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 123-394 5.2e-14 46.9 In-house 9-273 (288) alignment 
Range on Protein: 123-394
Range on HMM: 9-273/288.0
SIKFVKSLGSINLKDEYDEIQKLpVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFH
 |..| . .   || || .  .   . .  . . . ..|.|...  . |  |. ..   | ||.   .   ..   .   | |      ..||.|.....
wirlvlqiaveglkkeyrdspne.asidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPl...ngtieelWkmlle

EQCQTVHIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSVYLHTyWKPLFGPDRFGAQIRAAHQIakn
.. . . ....  |.  .. .. |  . |     . .   ..|  .  .    . ..    ||  . ..  ..|.  |.    |. . . .|  . .   
sdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlle.WdddgvPenylsplrllevl...

ENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY-MATNWLIK
.. . | |. | .|.|| ..|    .. ..|       | ...   ||.| ... .  ||. .. .  . |. 
kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 156-387 6.9e-14 46.5 In-house 45-272 (287) alignment 
Range on Protein: 156-387
Range on HMM: 45-272/287.0
QSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGawLY
..   .|| ..   .| .|.... ...|||| . |.  .      . . |    .... .||... ... ... .... .| .. .  . . .|.   ..
sqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPm...fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vv

ANGFFVNTRKVEKKENAKADMFVVELLPEgCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE--NGNSPTVIASVNGSGRNAALLTLAVVEDQL
   . ..  . |....     . |.   .  ..  .   |  | |.      .. . .   ..  |..  .||.. |.   .. || | ..  |.  .. 
lGeyniellneevnagyierklevknknk.agdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc

TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
 .     . ....  | |.|.||    ||  .. 
kteGviDvfqvlksqriqkpgsvqtveqykfind
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 159-388 7.8e-14 46.4 In-house 8-235 (239) alignment 
Range on Protein: 159-388
Range on HMM: 8-235/239.0
SSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARpeeLTNPaiDKLFCQEsgAWL
 ..||. .   |||.|....      . |||| | .     .|  |.     .    .  .|||....|.   . ...    | .    |  |..   | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei..ssgdfwrmmwqerrcvivmltg...lieg..hkkkchq..ywp

YANGFFVNTRKVEKKENAKADMFVVELLPE--GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVED
 .   ..| |   .| .  ||  .  ..    | ..      |  | |     |.   | .   ..|.|.   |  | ||    | ||  |.| .  .  
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|  . |   | . |..|||.||. |..  ||| ...|
qakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 159-388 7.9e-14 46.4 In-house 9-236 (239) alignment 
Range on Protein: 159-388
Range on HMM: 9-236/239.0
SSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARpeeLTNPaiDKLFCQEsgAWL
 ..||. .   |||.|....      . |||| | .     .|  |.     .    .  .|||....|.   . ...    | .    |  |..   | 
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcvei..ssgdfwrmmwqerrcvivmltg...lieg..hkkkchq..ywp

YANGFFVNTRKVEKKENAKADMFVVELLPE--GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNE-NGNSPTVIASVNGSGRNAALLTLAVVED
 .   ..| |   .| .  ||  .  ..    | ..      |  | |     |.   | .   ..|.|.   |  | ||    | ||  |.| .  .  
dstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
|  . |   | . |..|||.||. |..  ||| ...|
qakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 135-393 1.5e-13 45.5 In-house 17-276 (281) alignment 
Range on Protein: 135-393
Range on HMM: 17-276/281.0
LKDEYDEIQKLPVQ-TERCKMWQSHSSRNRHNDSKCYDHNRIIV----QMCKDDYINGSKINVPHfTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCQTV
.. ||...... |. | .    .    .||...   ||. |. |    .  . |||| . ..  .  .  |.. | |     .....||..|. .. ...
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvP...aslvafWqmvweqkvsai

HIIARPEELTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKENAkADMFVVeLLPEGCSnaVMCSVYLHTYWKPLFGPDRFGAQIRAAHQI--AKNENGN
 ...|  |  .    . . ... .  |..    .|.. ||.. .    | .    .| .  .  .   .| |     |.   . .   ...  ..... .
vmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyi.erkfkl.eresget..reveqlaytaWPdhGvPattkellefrkevlkltekktk

SPTVIASVNGSGRNAALLTLAVVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
 | ||    | ||  . ..|  . .....  .| .....|. .|..|   | . .||  .| |    .
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 135-388 1.7e-13 44.8 In-house 22-231 (392) alignment 
Range on Protein: 135-388
Range on HMM: 22-231/392.0
LKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHI
. .|. ..   ..  ...   .    .||...   || .|...    .. ..||.| | |.  .   .    | |.. |.|   .|||.||.|.  |. .
ffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaasld...dfwrmvfqenvttiam

IARPEELTnpaidklfcqesgawlyangffvntrkvekkenakadmfvvellpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNS-PT
... .|                                                   .|  .. .  | |     | .  . ..  ...  .    . | 
vtklkegd..............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpl

VIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
.|    | || . ....  |  .  . .   . ..|  ||..||  |..  ||  .| |
iihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyga
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 152-389 2.1e-13 44.6 In-house 41-275 (439) alignment 
Range on Protein: 152-389
Range on HMM: 41-275/439.0
CKMWQSHSS-RNRHNDSKCYDHNRIIVQ----MCKDDYINGSKINVpHFTPSIYLV-QLPKMdsvDAVEEFWRVVFHEQCqtVHIIArpeeLTNPAIDKL
. . |...  .||..|   .|| |...|    . .  |||   |.  .... .|.  | ||    .....|||.|.....  |.|.     |||      
slaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikG.yyddklyiatqgpkk...ettddfwrlviekkt..vtivm....ltnlvesyk

FCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCSvYLHTYWKPLFGPDR--FGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAAL
.   ..   | .      |..|  . .   . |..    .  .  .   . .. |     | .  .  .   | . |....   | |.    | ||  ..
ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlq.fhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGti

LTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
..| .  .||   ..  |  ||. .|.|| | |..  ||| .| | 
ialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_PTPN1_pd Subfamily PTPN1 156-366 3.5e-13 43.9 In-house 30-244 (290) alignment 
Range on Protein: 156-366
Range on HMM: 30-244/290.0
QSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESG-AWL
..  ..||. | . ||| ||...  . |||| | .....   |  | | |  .   .|. ||..|.......| .. .  |  .    . . |.     |
penrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpn...tvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

YA--NGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAK---NENGNSPTVIASVNGSGRNAALLTLAVV
      . |.  . |.|.. .  .. .| |    .  ..   . .| |  .  |.  .| ..  ... .     .   |.||    | ||  ..  .  .
lledtklkvkliseerksyytvrllelenlktqetreil..hfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtc

EDQLTRGKEPKI---SEIVR
  .. . .. .    .. . 
lvliekkddlssvdikkvll
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 245-397 6e-13 43.0 In-house 180-342 (347) alignment 
Range on Protein: 245-397
Range on HMM: 180-342/347.0
LFCQESGAWLYANGFFVNTRKVEKKENAKADM--FVVELLPEGCSNAVMCSVYLHTYWKPLFGPDR---FGAQIRAAHQIAK-----NENGNSPTVIASV
.|  |.  .|  .|...|||.||  . .|. |  . ||.. ||||.| .. ||  | |     ||      | .||  . .      | .  .| |.   
ffpletdhylnlkgwlintravevdqrnknwmnkytvevvaegcseatfakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcd

NGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKL
 |  | |...  ... .|.  || |   .. . .|.||       | |     |. . .| ||
lgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsifytyairaalfylklkl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 136-389 8.7e-13 43.0 In-house 5-264 (274) alignment 
Range on Protein: 136-389
Range on HMM: 5-264/274.0
KDEYDEIQKLPVQT-ERCKMWQSHSSRNRHNDSKCYDHNRIIV--QMCKDD---YINGSKINVPHFTPSIYLVQLPKMdsVDAVEEFWRVVFHEQCQTVH
|| ..|  .||.   .. ..   ....||...    .. |...  .  .|.   |||   |  .. .  .|.     .  . .|..|||....|..| . 
kdlekeflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPl..pntvadfWrmiyqeevqviv

IIARPEELTNPAIDKLFCQESGAWLYA--NGFFVNTRKVEKKENAKADMFVVEllpeGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIA---KNEN
.... .|  .    . | .. .. .    ... ....|. .... .   .|..     ...   .  |..| |     ||.  . ..  ...    ..||
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlk....ylerersvkhywytdWPdhksPddantlldlvleveesreeen

GN-SPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
 . .|.|.    | ||  . ..  .   || . .   . .||  .| .|   |..  ||  .. | 
aklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 136-388 9.8e-13 42.7 In-house 27-274 (315) alignment 
Range on Protein: 136-388
Range on HMM: 27-274/315.0
KDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQM----CKDDYINGSKINVPHfTPSIYL-VQLPKmdsVDAVEEFWRVVFHEQCQTVHI
|..|. |    ..  .         .||. .   ||. |. . .     . ||.| . |.     .  |.  | |.   | .|..|||.||.|.. .. .
kqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn.kkrryiaaqgpn...vasvkdfwrlvfeedigkivm

IARPEELTNPAIDKLFCQEsgAWLYanGFFVNTRKVEKKEnakaDMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKN--ENGNSP
..   |  .   .| .  .    .|  | .  ||| |...    . . |  |     . .   | ||    |  |  ..   .   .. .|   .|  ..
ltnlvegekrkaekywpdk..kviy..Gkitvtrkseevn....teytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvga

TVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 |.   .| ||  ...||  | ||.   .   . .... .|..| . |..  ||  .| |
ivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiyda
0041856 (Phosphotyrosine protein) phosphatases II 160-393 1.1e-12 43.4 In-house 3-171 (182) alignment 
Range on Protein: 160-393
Range on HMM: 3-171/182.0
SRNRHNDSKCYDHNRiivqmcKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIArpEELTNPaidklfcqesgawlyangf
..||. |  .|||.|        |||| . .  .. .  . . | | ..    |..|.| . .....|.  ..  ||| .|                   
dknrysdilpydhsr......dldyInanlylgslpatrfiatqgplls...tvadflrmlkelgittivnlt..eelywp...................

fvntrkvekkenakadmfvvellpegcsN--AVMCSVYLHTYWKPLFGPDrFGAQIRAAHQIAKnenGNSPTVIASVNGSGRNAALLTLAVVEDQltrgk
                            .    .   ||.. |     || .   ..  ... .    . |...    | || ..|  . ... .     
............................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....

EPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
.  . |.|...|..||..| .  ||. |..|  .|.
gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_PTPRG_pd Subfamily PTPRG 128-396 1.2e-12 41.9 In-house 14-290 (563) alignment 
Range on Protein: 128-396
Range on HMM: 14-290/563.0
KSLGSINLKDEYDEIQKLPVQT-ERCKMWQSHS--SRNRHNDSKCYDHNRIIVQMCKD-----DYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRV
.. | | .. |....|.  ...   ... | ..   .||. .   ||. |. ..   .     |||| . |.  . .      | |     | .. |||.
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk...dtfddFWrm

VFHEQCQTVHIIARPEELTNPAIDKLFCQeSGAwLYANGFFVNTRKVEKKENAKADMFVVEL--L--PEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRA
.. .. ... .|.  .| ..   |  . .  .. .  . . |.  . |..       .|..   |   . | .  .   |  |.|     |.    ..  
iWeqnvaiivmitnlvergrrkcdvYWPk.des.etygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLif

AHQ-IAKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTK
...  | |..   |.|.   .| ||   .. |  .  |. . .   . .....|| ||.  | .  ||. |. |   .|..|
vkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 160-386 1.9e-12 41.9 In-house 5-232 (237) alignment 
Range on Protein: 160-386
Range on HMM: 5-232/237.0
SRNRHNDSKCYDHNRIIVQMC--KDDYINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYAn
 .||. . ..|||.|.... .  . |||| . ..    ||  |.     ..|  . ..||..|. |.|  . ...   |  .    | . .      |  
iknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgples..scddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg.

gffVNTRKVEKKENaKADMFVVELLPE---GCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENG---NSPTVIASVNGSGRNAALLTLAVVED
   | |  . |||.  .|  |  ||        .  .   |  | |     |..  | .|  ..| .. .     .| .|    | || . .| .  .  
...vltvslkkkee.fsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
|    |   | . | .| |.||  ...  ||| ..
qakekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 155-388 2.2e-12 41.6 In-house 32-265 (285) alignment 
Range on Protein: 155-388
Range on HMM: 32-265/285.0
WQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHFTPSIYLVQLPKMdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAwL
...    ||. | .| .  |....    |||  | . .|    | |.     .   ... .||.....|.   | ...   |         . .. |  .
yeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgpl..petlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge.v

YANGFFVNTrKVEKKENAKADMFVVELLPEGCSNAVMCSVYLH----TYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVE
   | .  |   | ||.| |   .  |      .|    .|.      .|   . |.     |   . . | .  . | ..    | || |... .    
vkfgkyeit.lteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyat

DQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 ..    . .. .||| .|  | |.|.|..|.. ||. 
irimenpniemldivremramrfqavqshmqflflyvv
subfamily_PTPRN_pd Subfamily PTPRN 155-388 4.5e-12 40.3 In-house 53-287 (297) alignment 
Range on Protein: 155-388
Range on HMM: 53-287/297.0
WQSHSSRNRHNDSKCYDHNRIIVQM----CKDDYINGSKINVPHFTPSIYLV-QLPKmdsVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCqE
 .   ..||...   |||.|. ..      |.|||| | |       ..|.  | |     . | .||..|... .  .  ..| ||    . .. .  .
aeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgpl...astvadfwqmvweqGvvvivnltrleeegvkqckrywp.d

SGAWLYANgFFVN--TRKVEKkENAKADMFVVELLPEGCSNAVmcSVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNS-PTVIASVNGSGRNAALLTL
 |. .|   . |.  . ..   ..     | .  |    . .|  . . .  |.    |    . .    .. |   | | | |. . .|.||  . . .
eGsevyhi.yevhlvsehiwc.ddylvrsfylknlqtsetrtv..tqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

AVVEDQLTRG-KEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 .| ..|..| ||  |.  .  .|.|||. | .  |.   ..|
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefalta
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 151-389 1.8e-11 38.8 In-house 41-284 (325) alignment 
Range on Protein: 151-389
Range on HMM: 41-284/325.0
RCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKD----DYINGSKINVPHFTPSIYLVQLPKMDSvdaVEEFWRVVFHEQCQTVHIIARPeELTNPAIDKLF
.  |     ..|| ..   .|..|....  ||    |||| | ..           | |. ..   ....||.|.  .|  | ..    .| .    . .
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat...indlWrlvldWrcsvvvvlnel.dlgkdrcavyw

CQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMCsvYLHTYWKPLFGPDRFGAQIRAA------H-QIAKNENGNSPTVIASVNGSGR
 .| |      |. |. | .|.  .    .. |    .| . .|    . .  |. .  . |  . |         . ..  | .. .| ..  ..| ||
pkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkq..fqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGr

NAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMAT
  ....|  . ...    .  | . |. .|..||. |..  ||. .| | 
tGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 160-388 1.8e-11 37.8 In-house 45-271 (515) alignment 
Range on Protein: 160-388
Range on HMM: 45-271/515.0
SRNRHNDSKCYDHNRIIV----QMCKDDYINGSKINVPHFTPSIYLVQLPKMDSVDaveEFWRVVFHEQCQTVHIIARPEELtnpaiDKLFCQESGAWLY
..||...   || .|...    .  . ||.| |.|.  .   .    | |.  |||   .|||.|..|.  |. .... .|      ||  | .      
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvd...dfWrlvlqenvttiamvtklkeg.....dkikcgkyWPdkp

ANGFFVNTRKVEK-KENAKADMFVVELLPEGCSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVEDQL
..     . |||    .| ...   .|     ...     .  | |     | .  . ..  ...   ... . | .|    | ||   ....  |  . 
gdsvkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

TRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
  ..   . ..|. ||..||. |    ||  .| |
kttrmvdvfnfvtnirqkrpylvqtqeqyafiyga
subfamily_egg_pd Subfamily egg 159-409 2.7e-11 37.7 In-house 41-286 (307) alignment 
Range on Protein: 159-409
Range on HMM: 41-286/307.0
SSRNRHNDSKCYDHNRIIVQMC----KDDYINGSKINVPHFTPSIYLVQLPKMdsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWL
  . | .  .| |  |. ...      ||.|   ...   .     | | |     ..|..|||.|| |..| . ...   |  .       ...  . .
lekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplk...ntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvt

YANGFFVNTRKVEKKENAKADMFVVELlpEGCSnavMCSVYLHtYWKplfGPDRFGAQIRAAHQI-AKNENGNSPTVIASVNGSGRNAALLTLAVVEDQL
   .. ... ||..| .    .  . |   |         .|  .|.   |  .. ...    ..  |  |   |.|. ...|  . |.|... .   .|
vpGslrienlkvdskadplfrvtklkl..vGgd...deerfle.hwq...gdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsl

TRGKEPK--ISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKTKLPSGHEVVSKIKK
 ||   |  . . |  .| .|. ||.| ..|. .|    ....  . | .|.    ..
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyer
0036282 (Phosphotyrosine protein) phosphatases II 182-386 2.8e-11 38.9 In-house 2-163 (174) alignment 
Range on Protein: 182-386
Range on HMM: 2-163/174.0
DDYINGSKINVPHFTPSIYLVQLPKMdsvdaveeFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQesgawlyangffvntrkvekkenakadmfvvel
.|||| | ... . || ... | |          ||. .......||    ...|| .  .  ..                                   
sdyinaspldlsyitprliagqgpla........fwemlkelgittvvmlleekelglykcinywpe.................................

lpEGCSNAVMCSVYLHTYWKPLFGPDRFG--AQIRAAHQIAKNeNGNSPTVIASVNGSGRNAALLTLAVVEDQLTrGKEPKISEIVRTIREQRPQSVDSY
     .   .   ||.. |     ||       ....... .. ... |...    | || ..|  .  .. .|   .  .. ..||..| |||..| . 
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtp

IQYVSLY
 ||  ||
sQyrfly
0043147 (Phosphotyrosine protein) phosphatases II 182-392 3.1e-11 38.8 In-house 5-160 (172) alignment 
Range on Protein: 182-392
Range on HMM: 5-160/172.0
DDYINGSKINVPHFTPSIYLVQLPkmdSVDAVEEFWRVVFHEQCQTVHIIARPeeltnpaidklfcqesgawlyangffvntrkvekkenakadmfvvel
.|||| | ..... ....   | |       ...||| . .......  . .                                                
sdyinasyldlyyipdrfiatqgp...lrntladfwrmlkelgithivnltel...............................................

LPEGCSNAVMCSVYLHTYWKPLFGPdRFGAQIRAAHQIAK--NENGNSPTVIASVNGSGRNAALLTLAVVEdqltrgKEPKISEIVRTIREQRPQSVDSY
|  .     .   ||...|     |  .   ... ..| .  ... . |...  . | || ..|  .  ..      .  .. |.|...||.||..| . 
lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnp

IQYVSLYMATNWL
 ||  ||.  ..|
sqyrflyyfekll
0046846 (Phosphotyrosine protein) phosphatases II 195-394 3.8e-11 38.5 In-house 15-174 (176) alignment 
Range on Protein: 195-394
Range on HMM: 15-174/176.0
FTPSIYLVQLP---KMDSVDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLyangffvntrkvekkenakadmfvvellpegcsnavm
 .....|  .|     . .. ...|.. ........|  .  . ||    .. .. .. .. .                                     
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................................

csVYLHTYWKPLFGPDRfGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDqltrGKEPKISEIVRTIREQRP-QSVDSYIQYVSLYMATN
   |||. |     ||   . ...  .| .  . . |...  . | || ..|. .  .|     .|  .. |.....||||| ..| .  ||  ||..  
..qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQyrflyefel

WLIK
.|.|
lllk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 142-386 6.9e-11 36.6 In-house 15-259 (283) alignment 
Range on Protein: 142-386
Range on HMM: 15-259/283.0
IQK--LPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDDYINGSKINVPHF--TPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEEL
...  .| .   ... . .   ||...   .| .|. ..    |||| . | | .       |..    .|  ..| .||..||.|.  .. ....  | 
lkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPld..rtvvdfWkmvfdekitaivmltklqed

TNPAIDKLFCQEsGAWLYANgFFVNTRKVEKKENAKADMFVVELlPEGCSNAVMCSVYLHTYWkPLFGPDRFGAQIRAAHQIA--KNENGNSPTVIASVN
 . .  . . .. |.  | . | |  ||   ..      ...      . .... . |    |   .|..     .    ..   ..|. ..| |.   .
lrikCsqyWPkr.GsedyGe.ftvtlrkettsnsfiikelllrv.nssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCst

GSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
| || |.......  ...       . ..|. .||||.  | .  ||  ..
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvh
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 150-386 4.9e-10 33.7 In-house 38-276 (290) alignment 
Range on Protein: 150-386
Range on HMM: 38-276/290.0
ERCKMWQSHSSRNRHNDSKCYDHNRIIVQ------MCKDDYINGSKINVPHFTPSIYLVQLPKMDsvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAID
   .. .| . .|| ..   || |||...       |...||| . |.  .   . ...| | ..    . .||... .|..  . ..    |  .    
vtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn...tlvdFWkliwqekvtiivmltniieegkvkCq

KLFCQESGAWlyANGFFVNTRKVEKKENAKADMFVVELLPEGcSNAVMCSVYLHTYWKPLFGPDRFGAQIRAAHQIAK--NENGNSPTVIASVNGSGRNA
. . ... .    . | ..  . |. ..     . |.   ..  .. .   |  | |..        . . . ... |    .|| . |.   .. || |
qYWpdsdtka..ygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsa

ALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLY
 ....|.  ..        . ..... | |.|.|| .  ||  ..
vfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgif
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 141-393 1.4e-09 32.4 In-house 3-264 (270) alignment 
Range on Protein: 141-393
Range on HMM: 3-264/270.0
EIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIVQMCKDD----YINGSKINVPHFTPSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEE
|..|  ....    .  ..  ||..|     . |....  ..|    |||   ..  .  .  |.     ...  ....|||....|. ... ...  ||
eldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpt..tlksfwrmiweekvtaivmttgleE

LTNPAIDKLFCQESGAWLYANGFFVNTRKVEKKENAKADMFVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFG---------AQIRAAHQIAKNENGNS
  .   .. . .|..  .  .  .......... .    .  ..|  .| .. ..   . .. |     | . .         . .|| ..  |. . ..
kgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLI
|...   .| ||   |..|  .   | . |.  . .|.. .|..|.. |.   ||  || |    .
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
0049260 (Phosphotyrosine protein) phosphatases II 213-387 2.2e-09 32.7 In-house 22-144 (152) alignment 
Range on Protein: 213-387
Range on HMM: 22-144/152.0
VEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFcqesgawlyangffvntrkvekkenakadmfvvellpegcsnavmcsVYLHTYWKPLFGPDRFGAQ
...||| . . ...|.  . ...||. .  ....                                                |||..|     ||     
ladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlpwpDhgvpdlsqll

IRAAHQIAK-NENGNSPTVIASVNGSGRNAALLTLAVVEdqltrgKEPKISEIVRTIREQRPQSVDSYIQYVSLYM
. . . | | ... . |...  . | || ..|  .  ..      .  .. |.|. .||.||..| .  |.  || 
lflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 159-394 3.7e-09 30.8 In-house 39-278 (287) alignment 
Range on Protein: 159-394
Range on HMM: 39-278/287.0
SSRNRHNDSKCYDHNRIIVQMCK---DDYINGSKInvPHFT-PSIYLVQLPKMDSvdAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQEsGAWL
 ..||. |   .|..|...        ||||   .  . .|    ...    . .  .| .|||.|....  .| ...|  | .   . | . .     .
vkknryadvlPiddtrvllsaegelGsdyinanyv..asytddeafiaaqgPiaa..tvrdfwravletrsasvitmtreveearlkcykywPer.evPm

YANGFFVNTRKVEKKENAkADMFVVELLPEGCSN-AVMCSVYLHTYWKPLFGPD-----RFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAV
   |. |   . ..||     .  . |.     .  |.  . | .. .    |      ||  ...   ..|.. ..  | |.    | ||   ||.. |
rvGGysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

VEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIK
. ..|    .  .. .|  .||.|   | . .|.  || |     |
lvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 159-386 5.8e-09 30.0 In-house 56-282 (305) alignment 
Range on Protein: 159-386
Range on HMM: 56-282/305.0
SSRNRHNDSKCYDHNRIIVQ-MCKDDYINGSKINVPHFTPSIYLVQLPKMDsvDAVEEFWRVVFHEQCQTVHIIARPEELTNPAIDKLFCQESGAWLYA-
 ..||..|  | |.. . ..     |||    . .|      ...    .|  ....||| .| ... . . ....  || .    . .    |  |   
itknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpld..qtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

NGFFVNTRKVEKKENAKADMFVVeLLPEGCSNAVMCSVYlHTYWKPLfgPDRF--GAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDQLT
.|  |.     |  .  |.. .  ||    |     ||  |  |     |||    ... .   ..     . | |.    | ||  .....  . ....
sgivvenvsgskpmerdaeiqit.llnltysgdqkmsvr.hlqwtew..pdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekia

RGKE-PKISEIVRTIREQRPQSVDSYIQYVSLY
  |. | . |.|...|.||  |... .||. ..
enkpcppmpelvkalrdqrafsiqndvqylfih
0049772 (Phosphotyrosine protein) phosphatases II 159-395 5e-08 28.5 In-house 47-282 (314) alignment 
Range on Protein: 159-395
Range on HMM: 47-282/314.0
SSRNRHNDSKCYDhNRIIVQM---CKDDYINGSKINVPhftPSIYLVQLPkMDSVdaVEEF----------WRVVF--HEQCQTVHI-------------
 ..||. |  ..| || |..       |||| | .. .    .    | | .. .  |. |          ||.|.    .. ....             
rdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgp.leit..vvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------IARPEELTnpaidklfcqesgawlyaNGFFVNTRKVEKkenakadmfvvELL--PEGCSNAVmcSVYLHTYWKPlFGPDrFGAQIRAAHQIA
        . .. ...                  |   . . .  |           | |  || .....    ||.. .   ....   ...... .. 
daAlgKtpllildgng..................neptaadlellk...........eelydpelferlg..ikylripvpD.gsap.lledfdeflefi

KNENGNSPTVIASVNGSGRNAALLTLAVVEDQLtrgKEpKISEIVRTIREQRP-----QSVDSYIQYVSLYMATNWLIKT
.. . ..|...    | || . ....| .  .|   .   . |... .|..||      .. ...||.  ..| . ..|.
eeadkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylkf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 130-245 7.3e-08 26.5 In-house 12-130 (301) alignment 
Range on Protein: 130-245
Range on HMM: 12-130/301.0
LGSINLKDEYDEIQKLPVQTERCKMWQSHSSRNRHNDSKCYDHNRIIV------QMCKDDYINGSKINVPHFTPSIYLVQLPkMDsvDAVEEFWRVVFHE
  | .....|.|...   ..   .. ....  ||... . ||.||||.      ..|. .||| | |.    .      | | |.    . .|||....|
khsnkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgp.mk..ktlvdfWrliwqe

QCQTVHIIARPEELTNPAIDKL
. ... ...  .| |.    . 
kpvsivmvtnlkegtkskceqy
0051429 (Phosphotyrosine protein) phosphatases II 182-395 1.4e-07 27.0 In-house 4-227 (272) alignment 
Range on Protein: 182-395
Range on HMM: 4-227/272.0
DDYINGSKINVPhftP-----S-IYLVQLPKMDSvdaVEEFWRVvFHEQCQTVHIIARPEELTNPAIDKLFC----------QESGAWLYANGFFVNTRK
..||| . .. .           .|. . |   .   ...|||   .... |.  . ..||.     |..             .|  .   . ..| . .
sgyiNardvggy...grvvkpgrlyrsggplplt...aadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtlls

VEKKENAKADMFVVELL-PEGCSNAVMCSVYlhTYWKPLFGPDRFgaqIRAAHQIAKNengNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPK----
.| ...   ......|| . | .  ||. .|  | |     |.     .... ..  .   . | ..    | .| . .  |  .  ....    .    
eellldyilrellltlllsagearevmhlhy..tdwpdhgvpqea...llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYll

----ISEIVRTIREQRPQSVDSYIQYVSLYMATNWLIKT
    . |.|. .|.|||..| .. ||. ||.|   |...
tnlyleeaveelraqrpgavqteeqylflyeallellrs
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 325-388 2.9e-06 21.4 In-house 227-290 (297) alignment 
Range on Protein: 325-388
Range on HMM: 227-290/297.0
GNSPTVIASVNGSGRNAALLTLAVVEDQLTRGKEPKISEIVRTIREQRPQSVDSYIQYVSLYMA
 | ....    | ||   ..   |. ..| ... |..  |.. .||||.. | .  |.  || |
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 137-236 3.7e-06 21.0 In-house 11-112 (297) alignment 
Range on Protein: 137-236
Range on HMM: 11-112/297.0
DEYDEIQKlPVQTERCKMWQSHSS--RNRHNDSKCYDHNRIIVQ--MCKDDYINGSKINVPHFTPSIYLVQlPKMDSVDAVEEFWRVVFHEQCQTVHIIA
.|.| . .   ..|   . .  ||  .||..|   .| .|. ..  . . ||||   .  |.    .. .   .    ..|..||..|.... ... ..|
aekdllld.eargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyil.aqGplsatvddfwtlvaeqdvrvivmva

RPEE
. .|
klqe
0051082 (Phosphotyrosine protein) phosphatases II 190-388 5e-06 21.7 In-house 6-148 (151) alignment 
Range on Protein: 190-388
Range on HMM: 6-148/151.0
INVPHFTPSIYLVQLPkmdsvdaVEEFWRVVFHEQCQTVHIIARPEELTnpaIDKLFCQESGawlyangffvntrkvekkenakadmfvvellpegcsna
||    |. .|. . |        ..|.. . .....|.  .  .||      .. ...| |                                      
infsyvtgglyrsggp.......ladflellkelgiktivnlrseeerg...ycpeylpelg......................................

vmcS--VYLHTYWKPLFGPDRFGAQIRAAHQIAKNeNGNSPTVIASVNGSGRNAALLTLAVVEDQltrgkePKISEIVRTIREQRPQSVDSYIQYVSLYM
      ....    | .| . . .......... . ..| |...    | || ..|  |  .  .        . |... .|..|| .| .  |.. ...
...ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfqlf

A
|
a
0048076 (Phosphotyrosine protein) phosphatases II 277-392 6.2e-06 21.5 In-house 34-142 (145) alignment 
Range on Protein: 277-392
Range on HMM: 34-142/145.0
FVVELLPEGCSNAVMcsVYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEDqltrgKEPKISEIVRTIREQRPQSV
. .   .|.... ..   ||.. |     || .   ... ..| .  . . |...    | || ..|  . ..       .   . |... .|.|||..|
lnltselellerlgi..qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgav

DSYIQYVSLYMATNWL
 .  |.  ||..  .|
pnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 278-389 6.9e-06 21.4 In-house 33-141 (144) alignment 
Range on Protein: 278-389
Range on HMM: 33-141/144.0
VVELLPEGCSNAVMCS--VYLHTYWKPLFGPDRFGAQIRAAHQIAKNENGNSPTVIASVNGSGRNAALLTLAVVEdqlTRGkePKISEIVRTIREQRPQS
|. | .|   . . .    |||. |     || .   ... . | .  . . |...    | || ..| .. ..    ..|    . |... .|..||..
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klg..lsleealalvrsrrpga

VDSYIQYVSLYMAT
| .  |.  |..  
vpnpgqlrfLleye