Gene PRL in Caenorhabditis elegans

Synonym: CELE_T19D2.2, prl-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP158_AA protein Get Run
CeleP158_AA_21-169 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PRL_pd Subfamily PRL 24-170 2.2e-74 242.5 In-house 2-148 (151) alignment 
Range on Protein: 24-170
Range on HMM: 2-148/151.0
PSEIAWGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHPDKSIAVHCVAGL
..||.. ||||||||||........||||.|.....||||||||||| .|...||.|||..|.||..|| ||...|..|....|||.|....||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVAIALIEAGMKYEDAVEMIRTQRRGALNQKQLKFLETYKAN
||||||||.||||||||||||||.||..||||.|.|||||||.|||.
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykak
0038934 (Phosphotyrosine protein) phosphatases II 33-167 1.2e-35 118.2 In-house 19-172 (194) alignment 
Range on Protein: 33-167
Range on HMM: 19-172/194.0
RFLITDRPNNSSIQSYIEELEKHGARAVVRVC----------------EPTYDTLALKEAGIDVLDWQFSD-GSPPPPEVIKSWFQLCMTSFKEHPDKSI
||.....| ..|...||||| ... . .||..                |..||.  ...|||..|...| | |..|. |.......|. . ..|.|.. .
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVAIALIE-AGMKYEDAVEMIRTQRRGAL-NQKQLKFLETY
||||.|||||...||| .||.  ||..|.|....|  |.||. ||..|. | ..
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkr
0043147 (Phosphotyrosine protein) phosphatases II 18-167 5.6e-34 112.7 In-house 6-156 (172) alignment 
Range on Protein: 18-167
Range on HMM: 6-156/172.0
TYFKPAPSEIAWGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHPDKSIAV
.|    . .. .  .||..|  | .. . .... | ..| ...|...| .||.  |.. || .| . . |...|..|.. ...... . . . |.. ..|
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlV

HCVAGLGRAPVLVAIALIEAGMKYEDAVEMIRTQRRGAL-NQKQLKFLETY
||.||.||...|||. |.. |...|.||...|..|.||  |. |..||  .
HCsaGvgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyf
0049260 (Phosphotyrosine protein) phosphatases II 30-166 1.3e-31 104.7 In-house 7-144 (152) alignment 
Range on Protein: 30-166
Range on HMM: 7-144/152.0
GKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHPDKSIAVHCVAGLGRAPVL
 ...|..|  | . .. .... | ..|....|...|.....    | .| .| ... |...|. . .  .. | .  ....... ..|||.||.||...|
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VAIALIEAGMKYEDAVEMIRTQRRGAL-NQKQLKFLET
||. |.. |...|.||...|..| ||  |. ||.||  
vaaylmllgvsleeavalvrekRpgavpnpgqlrflye
0046846 (Phosphotyrosine protein) phosphatases II 33-167 2e-29 98.0 In-house 24-168 (176) alignment 
Range on Protein: 33-167
Range on HMM: 24-168/176.0
RFLITDRPNNSSIQSYIEELEKHGARAVVRVCEP--------TYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHpdKSIAVHCVAGLG
|...|. | ........|.| ..| .|||...|.        ...   |...|| .| . . |...|. | . ...... .  ||.  . ..|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPVLVAIALIEA--GMKYEDAVEMIRTQRR-GAL-NQKQLKFLETY
|...|||. |.|   |...|.|....| ||. ||. ...|..||. .
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyef
0045098 (Phosphotyrosine protein) phosphatases II 27-167 1.1e-28 95.8 In-house 59-267 (278) alignment 
Range on Protein: 27-167
Range on HMM: 59-267/278.0
IAWGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDT----------------------------------------------LALKEAGIDV
| . ...|..|. | .| ...... | ..| ...|...| ....                                                |...|. .
idgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvth

LDW-QFSDGSPPPPEVIKSWFQLCMTSFKEH---------------PDKSIAVHCVAGLGRAPVLVAIALIEA----GMKYEDAVEMIRTQRRG-AL-NQ
|..  . |...|. ...||...|.    . .               ... ..||| ||.||. .|||. |.      |. ...||...|.||.| |. |.
lhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnl

KQLKFLETY
 |..||. .
eqyrflyef
0040439 (Phosphotyrosine protein) phosphatases II 27-167 1.5e-28 95.5 In-house 49-241 (249) alignment 
Range on Protein: 27-167
Range on HMM: 49-241/249.0
IAWGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPT---------------------------------------------YDTLALKEAGIDVL
  . |.||..|. | .... .... | ..| ...|......                                             ||   ..  .| ..
gyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqyt

DWQfSDGSPPPPEVIKSWFQLCMTSFKEH-PDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGAL-NQKQLKFLETY
||   .| || .| . ........ ..|  ... ..||| ||.||.....|. |.      | |. .|.||...|.||.||  |. |..||  .
dwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0045450 (Phosphotyrosine protein) phosphatases II 26-167 2.5e-28 95.1 In-house 101-299 (307) alignment 
Range on Protein: 26-167
Range on HMM: 101-299/307.0
EIAWGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTLA------------------------------------------LKEAGIDVLDW
.. . |..|..|. | .... .... | ..| ...|...|.....                                             .. .. |  .
dgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthf

QF---SDGSPPP-PEVIKSWFQLCMTSFKEH-PDKSIAVHCVAGLGRAPVLVAIALIEAG---------MKYEDAVEMIRTQRRGAL-NQKQLKFLETY
..    |.. || .| . ........ ..|. ... ..||| ||.||.....|. |.  .         . ...||...| || ||  |. |..||  .
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyea
0036282 (Phosphotyrosine protein) phosphatases II 18-167 9.7e-28 92.4 In-house 3-165 (174) alignment 
Range on Protein: 18-167
Range on HMM: 3-165/174.0
TYFKPAPSEIAWGKMRFLITDRPNNssiqsYIEELEKHGARAVVRVCEPTYDT------------LALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMT
.|..  |  . .   |..... | .     ..|.| ..| ..||...|. ..               |.. || .|.. . |...|. ... ...... .
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfvee

SFKEHPDKSIAVHCVAGLGRAPVLVAIALIEAGM--KYEDAVEMIRTQR----RGALNQKQLKFLETY
 ..|.|.. ..||| ||.||...|||. |.. |.  ...||....|..|    ..  .. |..||  .
alsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyf
0041856 (Phosphotyrosine protein) phosphatases II 30-168 6.4e-27 89.7 In-house 32-166 (182) alignment 
Range on Protein: 30-168
Range on HMM: 32-166/182.0
GKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTsfkehPDKSIAVHCVAGLGRAPVL
  .||..| .| .|.. .... | ..| ...|...|. |.   |. .|| .|.... |...|... . .. . .       ... ..||| ||.||...|
patrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eggpvlVHCsaGvgRtgtl

VAIALIE-AGMKYEDAVEMIRTQRRGALNQKQLKFLETYK
||. |..  |. .|.||...| .| |.  . .  |.. ..
vaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla
0044763 (Phosphotyrosine protein) phosphatases II 19-167 1.2e-26 88.8 In-house 18-166 (178) alignment 
Range on Protein: 19-167
Range on HMM: 18-166/178.0
YFKPAPSEIAWGkmrFLITDRPNnssiQSYIEELEKHGARAVVRVCEPTY------DTLALKEAGIDVLDWQFSDGSPPP-PEVIKSWFQLCMTSFKeHP
.. . .|||  |   ..... |.    ....| | ..| ...|...|...      |  ...|||| .| . ..|...|. .| .  ..... .  .  .
sdyinaseilpg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ek

DKSIAVHCVAGLGRAPVLVAIALI-EAGMKYEDAVEMIRTQRRGALNQKQLKFLETY
.. ..||| ||.||...|||. |. . |. .|.|.|..| .|..  |. ||..|. .
ggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyef
0042113 (Phosphotyrosine protein) phosphatases II 27-167 3.8e-26 87.4 In-house 47-238 (245) alignment 
Range on Protein: 27-167
Range on HMM: 47-238/245.0
IAWGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYD-------------------------------------------TLALKEAGIDVLDW
  . . .|..|. | ..... ... | ..| ...|...|....                                               .  .| ..  
gyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhyl

QFSDGSPPP-PEVIKSWFQLCMTSFKEHPDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGAL-NQKQLKFLETY
 . |...|. .| . ...... .  .|.... ..||| ||.||. ...|. |.      | |.  |.||...| ||.||  .. |..||  .
pwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0043336 (Phosphotyrosine protein) phosphatases II 29-166 5.6e-25 83.8 In-house 85-271 (278) alignment 
Range on Protein: 29-166
Range on HMM: 85-271/278.0
WGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPT--------------------------------------------YDTLALKEAGIDVLDWQ
. ...|..|  |.....  ... . ..| . .|...|..                                            .|   ..  ..  |.| 
nvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp

fSDGSPPPPEVIKSWFQLCMTSFKeHPDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGAL-NQKQLKFLET
  .| |.... . .. .  .. .. .... ..|||.||.||. ...|. |.      | |. .|.||...|.|| ||. .. |..||  
.dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 33-167 9.2e-25 83.0 In-house 45-237 (243) alignment 
Range on Protein: 33-167
Range on HMM: 45-237/243.0
RFLITDRPNNSSIQS----YIEELEKHGARAVVRVCEPT------------------------------------------YDTLALKEAGIDVLDWQFS
|. .|. | ......    ... | ..| ...| ..|..                                          .|.  |.  .| .. . . 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGSPPP-PEVIKSWFQLCMTSFKE-------HPDKSIAVHCVAGLGRAPVLVAIALIEA--GMKYEDAVEMIRTQRRG-AL-NQKQLKFLETY
|...|. || . .... . .  .|       .... ..|||.||.||. .|.|. |.    |. .|.||...|.|| | |  .. |..||  .
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0039614 (Phosphotyrosine protein) phosphatases II 31-167 1.4e-24 82.5 In-house 100-284 (297) alignment 
Range on Protein: 31-167
Range on HMM: 100-284/297.0
KMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTL----------------------ALKEAGID-------------------VLDWQfSDGS
...|..|  |..... .... . ..| ...|........                          ...|.                    ...|   .| 
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.dhgv

PPPPEVIKSWFQLCMTSFKEH-PDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGAL-NQKQLKFLETY
|| .|.. ....|... ..|  ... ..|||.||.||. ...|. |.      | |. ...||...| ||.||  .  |..||  .
ppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyda
0051082 (Phosphotyrosine protein) phosphatases II 34-165 2.9e-24 80.8 In-house 15-145 (151) alignment 
Range on Protein: 34-165
Range on HMM: 15-145/151.0
FLITDRPNNssiqSYIEELEKHGARAVVRVCEPT---YDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHPDKSIAVHCVAGLGRAPVLV
..... | .     ..|.|...| ...| .....   |..  |.|.||.||.... | ..|. ...  ...  .  . ..... ..||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

AIALIEAGMKYEDAVEMIRTQRRGALNQKQLKFLE
|. |.  |. .|.|.|..| .| |. . .|  ...
alylmllgvsleealeeyrlkrpgvvqpnqqflfq
0040438 (Phosphotyrosine protein) phosphatases II 29-167 1.7e-23 78.8 In-house 83-271 (317) alignment 
Range on Protein: 29-167
Range on HMM: 83-271/317.0
WGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDT------------------------L--AlkEAGIDVLDWQF-----------------
. |..|..|  | .... .... . ..| . .|...|....                               .||| ..  ..                 
nlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhyt

--SDGSPPP-PEVIKSWFQLCMTSFKeHPDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGAL-NQKQLKFLETY
   |...|| |. . ...... .... .|.. ..|||.||.||. ...|. |.      | |. .|.||...| ||.||  .  |..|| ..
gWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
PTEN_1 41-169 4.8e-23 77.0 In-house 52-189 (196) alignment 
Range on Protein: 41-169
Range on HMM: 52-189/196.0
NNSSIQSYIEELEKHGARAVVRVCE------PTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHP-DKSIAVHCVAGLGRAPVLVAIA
. ...... ..|...|...||...|      ..||    .. |. .|.  . |  .|. . .  .   .. . ...|  . ..||| |||||  ..||  
slkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaay

LIEAG-MKYEDAVEMIRTQR-RGALNQKQLKFLETYKA
|...| . ...|.|..| .| .||.|. ... |. | |
LmykgkltadeAlelvrekRppgapnspsqerlleyfa
0049772 (Phosphotyrosine protein) phosphatases II 33-168 9.9e-22 73.5 In-house 147-274 (314) alignment 
Range on Protein: 33-168
Range on HMM: 147-274/314.0
RFLITDRPNNSSIQSYIEELEkhgaravvrvcEPTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSfkeHPDKSIAVHCVAGLGRAP--VLV
 .|| | ..|    ...|.|.           | .||   ....|| .|.. ..|||.|..| ........ .    .... ..||| || ||..  |..
pllildgngneptaadlellk...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvva

AIALIEAGMKYEDAVEMIRTQRR-----GALNQKQLkFLETYK
|. ..  |. .|.|.|..| .|      |...| .. ... ..
aylmkllgvsleealedvrlkRpinpnpgfieqleq.yefile
0048179 (Phosphotyrosine protein) phosphatases II 47-167 3e-21 71.1 In-house 20-140 (144) alignment 
Range on Protein: 47-167
Range on HMM: 20-140/144.0
SYIEELEKHGARAVVRVCEPtYDTLALKEAGIDVLDWQFSDGSPPPP-EVIKSWFQLCMTSFKehPDKSIAVHCVAGLGRAPVLVAIALI-EAGMKYEDA
. .|.| |.| ..|....|. |.   |.  || .| . . | ..|.  | . ...... .  .  ... ..||| ||.||...|||. |. . |. .|.|
ldlellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleea

VEMIRTQRRGAL-NQKQLKFLETY
....|..| ||  |. ||.||. |
lalvrsrrpgavpnpgqlrfLley
0047943 (Phosphotyrosine protein) phosphatases II 29-162 3.1e-21 71.5 In-house 74-262 (273) alignment 
Range on Protein: 29-162
Range on HMM: 74-262/273.0
WGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYD----------------TLALKEAGID--------------------------------V
. |..|..|. | .... ...  . ....| .|...|....                .|  ..  .                                 .
nlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhy

LDWQfSDGSPPPPEVIKSWFQLCMTSFKEH-PDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGALN-QKQLK
..|   .| || .| . ....|... ...   .. ..|||.||.||. ...|. |.      | |. ...|| ..|.|| |.     |..
tgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyr
0050432 (Phosphotyrosine protein) phosphatases II 29-160 6.4e-21 70.4 In-house 105-286 (308) alignment 
Range on Protein: 29-160
Range on HMM: 105-286/308.0
WGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTYDTL-------------ALKEAGI-----------------------------------DV
. ...|..|  | .... ...  . ... | .|........                 .| |                                      
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhy

LDWQfSDGSPPPPEVIKSWFQLCMTSFkehPDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGALNQKQ
..|   .| || || . ....|. .|.   |.. |.||| ||.||. ...|. |.      | |. ...|| ..|.|| |. . ..
tnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0051299 (Phosphotyrosine protein) phosphatases II 29-159 9.7e-21 69.9 In-house 89-272 (288) alignment 
Range on Protein: 29-159
Range on HMM: 89-272/288.0
WGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPT-------------------------------------------------YDTLALKEAGID
. |..|..|  | .... ..   . ... | .|......                                                 .|   ..   . 
nlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfh

VLDWQfSDGSPPPPEVIKSWFQLCMTSFKeHPDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGALNQK
...|   .| |. || . .. .|...... .... ..||| ||.||. ...|. |.      | |. ...||...|.|| |. .  
ytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_CDC14_pd Subfamily CDC14 43-168 4e-20 66.9 In-house 199-320 (328) alignment 
Range on Protein: 43-168
Range on HMM: 199-320/328.0
SSIQSYIEELEKHGARAVVRVCEPTYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSfkehpDKSIAVHCVAGLGRAPVLVAIALIE-AGMKY
 . ....|   |.. ..|||. .  ||    ..||.|  |  | ||| |. ...|.. ... ..     . .||||| |||||.  |.|  |..  ..  
haPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrfta

EDAVEMIRTQRRGALNQKQLKFLETYK
..|.  .|  | | .  .| ||||. .
aeaiawlricrPGsvigpqqkfleekq
0048076 (Phosphotyrosine protein) phosphatases II 47-167 1.7e-19 65.4 In-house 20-138 (145) alignment 
Range on Protein: 47-167
Range on HMM: 20-138/145.0
SYIEELEKHGARAVVRVcepTYDTLALKEAGIDVLDWQFSDGSPPPP-EVIKSWFQLCMTSFKEHpdKSIAVHCVAGLGRAPVLVAIALIEA-GMKYEDA
. .|.|...| ..|...   |...  |.. || .| . . | ..|.  | . ...... .  ||.  . ..||| ||.||...|||. |.   |. .|.|
ldlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmlllgvsleea

VEMIRTQRRGAL-NQKQLKFLETY
.|..|.||.||  |. ||.||. .
lelvrsqrpgavpnpgqlrflyef
0046845 (Phosphotyrosine protein) phosphatases II 29-159 1.8e-19 65.6 In-house 74-260 (284) alignment 
Range on Protein: 29-159
Range on HMM: 74-260/284.0
WGKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPTY-----------------------------------------------DTLALKEAGIDVL
. |..|..|  | .... ..   . ....| .| ..|..                                                .   ..   . ..
yikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhyt

DWQfSDGSPPPPEVIKSWFQLCMTSFKE-HPDKSIAVHCVAGLGRAPVLVAIALIEA---------GMKYEDAVEMIRTQRRGALNQK
.|   .| || || . ....|. ..... .... |.||| ||.||. ...|. |.           |. ...|| ..|.|| |. .. 
swp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
0051429 (Phosphotyrosine protein) phosphatases II 33-169 4.2e-19 64.7 In-house 23-222 (272) alignment 
Range on Protein: 33-169
Range on HMM: 23-222/272.0
RFLITDRPNNSSIQSyIEELEKHGARAVVRVCEPT---YDTLALKEAGIDVLDWQFSDGSPPPP------------------------------------
|.. ...| . .... .. |...| ...| .....   ..   .  .||..| . . | |.|..                                    
rlyrsggplpltaad.fwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------EVIKSWFQLCMTsfkehpDKSIAVHCVAGLGRAPVLVAIALIEAGMK--------------YEDAVEMIRTQRRGAL-NQKQLK
                | ......|. .      .. . ||| || .|  ..||. |. .|.               .|.|||..| ||.||  .. |..
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

FLETYKA
||  . .
flyeall
0036941 (Phosphotyrosine protein) phosphatases II 30-164 8.2e-17 56.9 In-house 76-269 (297) alignment 
Range on Protein: 30-164
Range on HMM: 76-269/297.0
GKMRFLITDRPNNSSIQSYIEELEKHGARAVVRVCEPT--------------------YDTLALKEAGIDV-----------------------------
 |..|..|  | .... ..   . ... . .| ..|..                    |. . ..  ...|                             
lkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhy

LDWQfsDGSPPP-PEVIKSWFQLCMTSFKEH-PDKSIAVHCVAGLGRAPVLVAIAL---------IEAGMKYEDAVEMIRTQRRGALNQK-QLKFL
..|   | ..|. |. . ....|. .  |.  ... . |||.||.||. ...|. |         .| |. . .|| ..|.|| ||  .  |..||
tgwp..dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl
subfamily_PTPDC1_pd Subfamily PTPDC1 67-168 3.2e-12 41.3 In-house 72-172 (182) alignment 
Range on Protein: 67-168
Range on HMM: 72-172/182.0
TYDTLALKEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHpdkSIAVHCVAGLGRAPVLVAIALI-EAGMKYEDAVEMIRTQRRGALNQ-KQLKFL
.||. ||.|.|| |  . ..| . .. | |    ..   . .|     .|||| |||||. ||.|  |.    .. |.|....| .|  ...  .|....
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelv

ETYK
. ..
kefa
PTPc_DSPc_SM00012 81-160 7.8e-12 40.7 In-house 8-94 (105) alignment 
Range on Protein: 81-160
Range on HMM: 8-94/105.0
LDWQFSdGSPPPPEVIKSWFQLCMTSFKEHP-DKSIAVHCVAGLGRAPVLVAIALIEAGMKYE-------DAVEMIRTQRRGALNQKQ
..|.   | | ... | .... .... ...   |.. ||| || ||. ..||....   ...|       . |...|.||.|. ....
tgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee
subfamily_RNGTT_pd Subfamily RNGTT 59-158 1.6e-11 38.2 In-house 57-160 (189) alignment 
Range on Protein: 59-158
Range on HMM: 57-160/189.0
AVVRV--CEPTYDTLALKEAGIDVLDWQFS-DGSPPPPEVIKSWFQLCMTSFKEHPDKSIAVHCVAGLGRAPVLVAIALIEA-GMKYEDAVEMIRTQRRG
 |. .   .. ||. .|.. ||     |    |  | .| .|.. .|. . ||..|.. |.|||  |  |.  |..  |.|   .. |.||.. .. |  
lvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRpp

ALNQ
 . .
Giyk
0048567 (Phosphotyrosine protein) phosphatases II 59-165 2.4e-11 38.2 In-house 19-131 (157) alignment 
Range on Protein: 59-165
Range on HMM: 19-131/157.0
AVVRVCEPTYDTLAL-KEAGIDVLDWQFSDGsPPPPEVIKSWFQLCMTSFK--EHPDKSIAVHCVAGL---GRAPVLVAI-ALIEAGMKYEDAVEMIRTQ
...|. . .|..| .  ..|.  .|. | .| |..  .. ..... .  .|  |. .| ||||| |||   ||. .|..  ...  |.  |.|....|  
llprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplriv

RRGALNQKQLKFLE
| | .   .  .|.
rpgsvpfrdasyll
subfamily_PTEN_pd Subfamily PTEN 44-150 1.3e-09 33.3 In-house 49-154 (184) alignment 
Range on Protein: 44-150
Range on HMM: 49-154/184.0
SIQSYIEELEkHGARAVVRV-CEPTYDTLALkeaGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHPDKSIAVHCVAGLGRAPVLVAIALIEAGMKYE
 .. ..|.   ..   .  .  | .||.  .      |  ..|.|  ||| |....  .   . ..| ... ..||| || ||. ||..  |.....  .
dvvkflekkh.kdhykiynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllek

--DAVEMIRT
  .|.|.  .
aeealelfae
subfamily_DSP23_pd Subfamily DSP23 77-158 3.5e-09 31.5 In-house 51-131 (148) alignment 
Range on Protein: 77-158
Range on HMM: 51-131/148.0
GIDVLDWQFSDGSPPPPEVIKSWFQLcMTSFkEHPDKSIAVHCVAGLGRAPVLVAIALI-EAGMKYEDAVEMIRTQRRGALNQ
.. .   .  |  || .| .. . .. .    |. .....|||. | ||.  ..|  |. | ..   .|.  .| .| |... 
nltlvrlriddyhppaleqvvefvrv.veea.eekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvet
Y_phosphatase Protein-tyrosine phosphatase 93-164 4.9e-09 31.3 Pfam-A 149-229 (235) alignment 
Range on Protein: 93-164
Range on HMM: 149-229/235.0
PEVIKSWFQLCMTSFKEH--PDKSIAVHCVAGLGRAPVLVAIALIEAGMKY------EDAVEMIRTQRRGALNQ-KQLKFL
||  || ..|.    |..   .... ||| || ||. ..||. ..   ..        ..|...|.||.|. .. .|..||
pespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 93-164 4.9e-09 31.3 In-house 149-229 (235) alignment 
Range on Protein: 93-164
Range on HMM: 149-229/235.0
PEVIKSWFQLCMTSFKEH--PDKSIAVHCVAGLGRAPVLVAIALIEAGMKY------EDAVEMIRTQRRGALNQ-KQLKFL
||  || ..|.    |..   .... ||| || ||. ..||. ..   ..        ..|...|.||.|. .. .|..||
pespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifl
DSPc Dual specificity phosphatase, catalytic domain 96-158 7e-09 30.7 Pfam-A 55-120 (133) alignment 
Range on Protein: 96-158
Range on HMM: 55-120/133.0
IKSWFQLCMTS--FKEHPDKSIAVHCVAGLGRAPVLVAIALIE-AGMKYEDAVEMIRTQRRGALNQ
| .... ...     |   |...||| ||. | . |..  |..  ......|.|... .|     .
iskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispn
DSPc Dual specificity phosphatase, catalytic domain 96-158 7e-09 30.7 In-house 55-120 (133) alignment 
Range on Protein: 96-158
Range on HMM: 55-120/133.0
IKSWFQLCMTS--FKEHPDKSIAVHCVAGLGRAPVLVAIALIE-AGMKYEDAVEMIRTQRRGALNQ
| .... ...     |   |...||| ||. | . |..  |..  ......|.|... .|     .
iskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispn
subfamily_PTPMT1_pd Subfamily PTPMT1 72-170 1.6e-08 29.2 In-house 68-167 (171) alignment 
Range on Protein: 72-170
Range on HMM: 68-167/171.0
ALKEAGIDVLDWQFSDGS-PPPPEVIKSWFQLCMTSFKEhpDKSIAVHCVAGLGRAPVLVAIALI-EAGMKYEDAVEMIRTQRRG-ALNQKQLKFLETYK
  |. |.. |  .  |    |  | ..   ..     ..   |.. ||| || ||.  |||  |. .  .. |.|.......|.   |..||.| |. |.
ewkklgveqlqlatvDfteapdleklekgvefiekvask..gkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye

AN
 .
ek
subfamily_DSP15_pd Subfamily DSP15 112-176 3.1e-08 27.8 In-house 78-147 (151) alignment 
Range on Protein: 112-176
Range on HMM: 78-147/151.0
DKSIAVHCVAGLGRAPVLVAIALIEA-GMKYEDAVEMIRTQRRGALN----QKQLKFLETYKANGELRRL
.... |||.||. |.  ||.. |. .  ....||.|.|...|  |      ..|||  |. |.. . ..|
eenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrkql
PTPc_motif_SM00404 109-165 3.7e-08 28.4 In-house 77-132 (140) alignment 
Range on Protein: 109-165
Range on HMM: 77-132/140.0
EHPDKSIAVHCVAGLGRAPVLVAIALIE-AGMKYEDAVEMIRTQRrgALNQKQLKFLE
|   ... ||| ||. |   |..  |..  ......|.|... .|     ...|.|..
ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..piispnlnfvr
subfamily_DSP11_pd Subfamily DSP11 68-159 4.6e-08 27.2 In-house 70-164 (178) alignment 
Range on Protein: 68-159
Range on HMM: 70-164/178.0
YDTLALKEAGIDVLDWQFSDGSPPPPEVIKSwFQLCMTSFK---EHPDKSIAVHCVAGLGRAPVLVAIALIE-AGMKYEDAVEMIRTQRRGALNQK
|.. .|.. |.  |  . .  . |  |..|. |.  ...|.   .. || |.|||  |. |.  |.   ||.  |.. |||.|.  . |  .|...
ykkkeltdegvkylklncpGhevpkeelvkk.fkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslere
subfamily_PTPN13_pd Subfamily PTPN13 102-170 2.3e-07 25.4 In-house 193-265 (273) alignment 
Range on Protein: 102-170
Range on HMM: 193-265/273.0
LCMTSFKEhPDKSIAVHCVAGLGRAPVLVAIALI------EAGMKYEDAVEMIRTQRRGALnQKQLKFLETYKAN
  . ....     |.||| ||.||. .|..|  .      .  .. .. |. .| ||.| . | . ...  ||| 
aevrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvv.qtkdqyifvykai
subfamily_DSP3_pd Subfamily DSP3 109-168 3.3e-07 24.1 In-house 94-154 (162) alignment 
Range on Protein: 109-168
Range on HMM: 94-154/162.0
EHPDKSIAVHCVAGLGRAPVLV-AIALIEAGMKYEDAVEMIRTQRRGALNQKQLKFLETYK
....  . ||||.|. |...|| |  .|   |.  .|.. .|..|.   |.  || | ...
sqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqLaeld
subfamily_DSP19_pd Subfamily DSP19 94-158 4.1e-07 24.5 In-house 69-137 (152) alignment 
Range on Protein: 94-158
Range on HMM: 69-137/152.0
EVIKSWFQLCMTSFKEHPDK--SIAVHCVAGLGRAPV-LVAIALIEAGMKYEDAVEMIRTQRRGAL-NQ
. . |... ..   .|  .|   . ||| ||  |..   .|  . .  ...|.|.|..|..|. .  |.
tdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpcikPne
subfamily_CDKN3_pd Subfamily CDKN3 74-168 4.9e-07 23.5 In-house 96-192 (202) alignment 
Range on Protein: 74-168
Range on HMM: 96-192/202.0
KEAGIDVLDWQFSDGSPPPPEVIKSWFQLCMTSFKEHpdKSIAVHCVAGLGRAPVLVAIAL--IEAGMKYEDAVEMIRTQRRG-AL-NQKQLKFLETYK
..||. |  . ..||  | .      ..   ...|..  .   |||  ||||. ...|  |  ..  ....||.. .|  .   |.   ||  .|. ..
qqaglivhhypiadglvpdiasclkileelrinlkay..rktlvhcygglgrsslviaclllylddtiepkdaidklrdlkgsraiqtvkqynylsefr
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 108-164 2.7e-06 21.9 In-house 220-281 (319) alignment 
Range on Protein: 108-164
Range on HMM: 220-281/319.0
KEHPDKSIAVHCVAGLGRAPVLVAIALIEAGMKYEDAVEMIRT-----QRRGALNQKQLKFL
||.  ..| ||| || ||. | ...  .   || |. |.. ..     |.|  | |.  .. 
kenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 107-164 2.8e-06 22.0 In-house 183-245 (284) alignment 
Range on Protein: 107-164
Range on HMM: 183-245/284.0
FKEHPDKSIAVHCVAGLGRAPVLVAIALIEAGMKYEDAVEMIRT-----QRRGALNQKQLKFL
 ||.  ..| ||| || ||. | ...  .   || |. |.. ..     |.|  | |.  .. 
skenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk
subfamily_DSP12_pd Subfamily DSP12 103-167 2.9e-06 21.8 In-house 71-139 (155) alignment 
Range on Protein: 103-167
Range on HMM: 71-139/155.0
CMTSFKEH--PDKSIAVHCVAGLGRA-PVLVAIALIEAGMKYEDAVEMIRTQRRGA-LNQKQLKFLETY
...  .|    .... ||| ||. |   . .|  . . ... |.|......... .  |.  |. |  .
avdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklf
subfamily_PTPN12_pd Subfamily PTPN12 104-149 3.4e-06 21.1 In-house 199-253 (290) alignment 
Range on Protein: 104-149
Range on HMM: 199-253/290.0
MTSFKEHPDKSIAVHCVAGLGRAPVLVAIALIEAGMKYEDA---------VEMIR
. ...|. |. ..||| || ||. ...|| ..   .| |           |  .|
vrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelr
DSPc_SM00195 105-160 3.4e-06 22.0 In-house 189-250 (263) alignment 
Range on Protein: 105-160
Range on HMM: 189-250/263.0
TSFKEHpDKSIAVHCVAGLGRAPVLVAIALIEAGMK------YEDAVEMIRTQRRGALNQK-Q
.| ..  .. | ||| ||.||. ..|.| .|   ..       .. |...|.|| |. ... |
ksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq
PTPc_SM00194 105-160 3.4e-06 22.0 In-house 189-250 (263) alignment 
Range on Protein: 105-160
Range on HMM: 189-250/263.0
TSFKEHpDKSIAVHCVAGLGRAPVLVAIALIEAGMK------YEDAVEMIRTQRRGALNQK-Q
.| ..  .. | ||| ||.||. ..|.| .|   ..       .. |...|.|| |. ... |
ksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq
subfamily_Ptp69D_pd Subfamily Ptp69D 93-153 4.6e-06 21.0 In-house 198-260 (307) alignment 
Range on Protein: 93-153
Range on HMM: 198-260/307.0
PEVIKSWFQLCMT--SFKEHPDKSIAVHCVAGLGRAPVLVAIALIEAGMKYEDAVEMIRTQRR
||| .. ..|     . ...    | ||| || ||. ..||....   .| || |... | . 
PevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkd
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 105-152 4.9e-06 20.9 In-house 210-257 (297) alignment 
Range on Protein: 105-152
Range on HMM: 210-257/297.0
TSFKEHPDKSIAVHCVAGLGRAPVLVAIALIEAGMKYEDAVEMIRTQR
 .|... .  . |||.||.||. ||..|  . | .| |..|..  . .
kdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvk