Gene ptp-2 in Caenorhabditis elegans

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP160_AA protein Get Run
CeleP160_AA_256-582 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN6_pd Subfamily PTPN6 256-587 2.8e-127 418.9 In-house 20-303 (306) alignment 
Range on Protein: 256-587
Range on HMM: 20-303/306.0
RESMEKTGISEEFDRLSQEAlpAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTdRPNTPGSDYINASYVRfeNSQRTKNvtfaceKSFIATQGCLE
.||.||.|..|||..|.||.  |...||..||..| |.||||||||.|||||||||. .|..||||||||.|..  .......      ||.||||||||
eeslekagfeeefeelqqee..akkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyik..kevkgsd......ksyiatqgcle

TTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNKPEvHGDISLTCTIERkvqravsdevkaeleqektnriakglvpeaelngDGISYILRT
||.||||.|||||||||||| |.|.|| |||||||||.| .|.| .|.||.|.. |.                                  .  .||||.
ttvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek..................................sladYilRe

LVM---KKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQpiaaslPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYK
|..   ||.|..||..|... .|||||.| .|.|||.|||||.|........       .||||||||||||||||..|.|.||....| || ...|..|
lsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleea......eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqk

MVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNPY
.||.||..|||||||||||.|.|||...|.......
lvksvreqrsglvqteqqykfvykaikkyietkkkl
DSPc_SM00195 264-582 5.2e-88 290.1 In-house 2-263 (263) alignment 
Range on Protein: 264-582
Range on HMM: 2-263/263.0
ISEEFDRLSQEALPAeqylSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFEnsqrtknvtfACEKSFIATQGCLETTISDFWS
..|||..| ... |     ...|.... | .|||||||.|.|||||.|.......|||||||.|....           ..|..|||||.|..|..||| 
lkeefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..........nkkkkyIatQgPlpstvedFWr

MVWQENSRVIVMPTMENE-RKEKCARYWPAEVNKPEVHGDISLTCTIERKVQravsdevkaeleqektnriakglvpeaelngdgISYILRTLVMKKGK-
|||.|....||| |.|.|  ||||.|||| | ...|..|.||.... . |..                                  ..||||| ..| . 
mvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk.................................deiilrtleltkegk

-DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYR
 .||...|.|| .|||||.| ..  ||..|. |. ...            .||||||||||.|||||....| .|.....      .|. ..|| .|. |
eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqR

SGLVQTEQQYQFLYKALAFYLK
 |.|||..||.|.|.|...|.|
pgmvqtleqYlfiyeaileyik
PTPc_SM00194 264-582 5.2e-88 290.1 In-house 2-263 (263) alignment 
Range on Protein: 264-582
Range on HMM: 2-263/263.0
ISEEFDRLSQEALPAeqylSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFEnsqrtknvtfACEKSFIATQGCLETTISDFWS
..|||..| ... |     ...|.... | .|||||||.|.|||||.|.......|||||||.|....           ..|..|||||.|..|..||| 
lkeefekleestspk....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..........nkkkkyIatQgPlpstvedFWr

MVWQENSRVIVMPTMENE-RKEKCARYWPAEVNKPEVHGDISLTCTIERKVQravsdevkaeleqektnriakglvpeaelngdgISYILRTLVMKKGK-
|||.|....||| |.|.|  ||||.|||| | ...|..|.||.... . |..                                  ..||||| ..| . 
mvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk.................................deiilrtleltkegk

-DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYR
 .||...|.|| .|||||.| ..  ||..|. |. ...            .||||||||||.|||||....| .|.....      .|. ..|| .|. |
eetrkvtqyqyknWpdhgvpdstksvlellravkksksts..........sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqR

SGLVQTEQQYQFLYKALAFYLK
 |.|||..||.|.|.|...|.|
pgmvqtleqYlfiyeaileyik
0050432 (Phosphotyrosine protein) phosphatases II 258-584 1.1e-84 279.7 In-house 38-302 (308) alignment 
Range on Protein: 258-584
Range on HMM: 38-302/308.0
SMEKTGISEEFDRLSQEALpaeqYLSKREGRRPVNAEKNRYKNIVPFDHTRVILtdrpnTPGSDYINASYVRFENsqrtknvtFACEKSFIATQGCLETT
 .......||| .| .       .|. . ...| | .|||||.|.|.||.||.|      .||||||||||.. .        . ... ||||||.|..|
aldlglleeefeellsvkp....lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgys........sklprkfIatqgPlpnt

ISDFWSMVWQENSRVIVMPTMENERK-EKCARYWPAEVN-KPEVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaELngdGISYILRTL
. ||| |||..|.||||| | . |.. ||||.||| |.. .....|....|.. |                               |      .|..|||
vedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllse...............................ev...lddytvrtl

VMKK--GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYdyfnaqpiaaslPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYKMV
 ...  ....|......|..|||||.| .| ..|.||| |.. .            |.||||||||||.|||||...|| ||.|..|    . .||...|
eltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl............pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeav

KYVRTYRSGLVQTEQQYQFLYKALAFYLKNN
|..|..| | |||..||.|||.||..|||. 
kklReqRpgmvqtpeqylflyralleylklk
0046845 (Phosphotyrosine protein) phosphatases II 264-585 5.4e-83 273.9 In-house 2-278 (284) alignment 
Range on Protein: 264-585
Range on HMM: 2-278/284.0
ISEEFDRLSQEALPaeQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNT-PGSDYINASYVRFENSQRTknvtfACEKSFIATQGCLETTISDFW
. ||| .| .   .  ..|| . ...| | .|||||.|.|.||.||.|.  ... ..|||||||||.. . . |      ..| |||||| |..|. |||
leeefeellsltvk..lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldlt.....yikkkfIatqgPlpntvedFw

SMVWQENSRVIVMPTMENERK-EKCARYWPAEvNKPEVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaELngdGISYILRTLVMKK--
 |||..|.||||| | . |.. ||||.||| | ... ..||.. |.. |                               |      .|..||| ...  
rmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllse...............................ev...kddytvrtleltnlg

-GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYfnaqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVKYVRT
 .. .|......|..|||||.| .|  .|.||..|.. ..         . ..||||||||||.|||||...|| ||.|..| |||. .||...||..|.
ytgesrtvthfhytswpdhgvppspedlleflrlvrellen........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlre

YRSGLVQTEQQYQFLYKALAFYLKNNN
.| | |||..||.|.|.||..|||. .
qRpgmvqtleqyrfvyealleylklkl
subfamily_PTPRD_pd Subfamily PTPRD 263-584 9.5e-83 273.7 In-house 24-284 (564) alignment 
Range on Protein: 263-584
Range on HMM: 24-284/564.0
GISEEFDRLSQEalpaeQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFW
 ..||. .....     |  .... . |.| .||||.|||..||.||.|.  ....||||||||..           ..  .|..||||| |..||.|||
kfeeeykkieeg.....qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid..........gyrkrkayIAtqgPlaetiedFW

SMVWQENSRVIVMPTMENERKE-KCARYWPAEvNkPEVHGDISLTCTIERKVQRAVSDEVKAELEQektnriakglvpeaelngdgisyilrtlvmkkGK
 |||..||..||| |  .|... ||..|||.. . .| .|..  | . | ...  .  . | . ..                                 .
RmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkk................................ss

DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDyfnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcpmDVYKMVKYVRTYRS
..||.|| ..  ||||| | .. ..|.....| .               .||||||||||.||||| .|.||.|...|. ...   |.|..|| .|. | 
esreVrqFhFtsWPdhgvpesatslLdlirkvralne..........pdagPivVhCSaGVGRTGtfividamlerikeektv...DiyqyvkalrkqRn

GLVQTEQQYQFLYKALAFYLKNN
 .||||.||.|...|.. .|.  
amVqteeQYiFiheailealacg
0051299 (Phosphotyrosine protein) phosphatases II 259-582 7.7e-82 270.3 In-house 20-287 (288) alignment 
Range on Protein: 259-582
Range on HMM: 20-287/288.0
MEKTGISEEFDRLSQEALPaeqyLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFensqrtknvtFACEKSFIATQGCLETTI
  .||. |||..| .   .    |. . ...| | |||||..|.|.||.||.|.. .. .|||||||||...          . ... ||||||.|..|.
ngltglleefeellsllpd....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidg..........ynlkrkfIatqgPlpntv

SDFWSMVWQENSRVIVMPTMENERK-EKCARYWPAevNKPEVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaELngdGISYILRTLVM
.||| |||..|.||||| | . |.. ||||.|||   ......|||. |.. |                               |      .|..||| .
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllse...............................ev...lddytvrtlev

K------KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDyfnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYK
.      ... .|......|..|||||.| .| ..|.||..|.. .            ..||.|||||||.|||||...|| ||.|..|      .||..
tnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..........sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvle

MVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
.||..|..| |.|||..||.|.|.||..|||
avkrlreqRpgmvqtpeqyrfvyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 260-587 3.9e-80 264.8 In-house 16-282 (317) alignment 
Range on Protein: 260-587
Range on HMM: 16-282/317.0
EKTGISEEFDRLSQEalpaeQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTIS
 .|...||| .| .      .. . .....|.| .||||..|.|.||.||.|.. .. ..|||||||||           .. . . ||||||.|. |. 
dftalleefedllsl.....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvd..........gpnlkrkfIatqgPlpntve

DFWSMVWQENSRVIVMPTMENER-KEKCARYWPAevNKPEVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaeLNGDGISYILRTLVMK
||| |||.....|||| | . |. .||||.|||   ... ..||.. |.. |                                   .|| .   ... .
dFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllse................................eelagitlrtlevedl

KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYdyfnaqpiAasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPMDVYKMVKYVRT
.....|......|..|||||.| .|  .|.||| |.. .        .   |.||..||||||.|||||..... .|.|..| |    .||.. ||..| 
gdsesrtvthfhytgWpdhgvppspdllldfleavreal........e..dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelre

YRSGLVQTEQQYQFLYKALAFYLKNNNPY
.|.| |||..||.|||.||..|||.....
qRpgavqtpeqyrflydalleylkrkltl
0036941 (Phosphotyrosine protein) phosphatases II 257-587 4.2e-80 264.5 In-house 8-283 (297) alignment 
Range on Protein: 257-587
Range on HMM: 8-283/297.0
ESMEKTGISEEFDRLsqeaLPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILtdrpNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLET
... ......||..|    ||   . |.. ...| | ||||||.|.|.|||||.|    . .||||||||||           .. ... ||||||.|..
kllflalllkefeel....lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvd..........gydlkrkfIatqgPlpn

TISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNKPEVHGDISLTCTIERKvqravsdevkaeleqektnriakglvpeaelnGDGISYILRTL
|. ||| |||..|..|||| | . |. .||||.||| |.... ..||...|.. . .                                 .  .|.||||
tvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvev................................vllddytlrtl

VMKK--GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMV
 ...  ....|......|..|||||.| .|. .|.|.| |.. ....         ..||..||||||.||.||....| .|.|...    . .|....|
evtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileav

KYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNPY
|..|..| | |||..||.||| ||...||.....
kklReqRpgavqtleqyrflyeallellkkkltk
0047943 (Phosphotyrosine protein) phosphatases II 258-581 4.8e-78 257.7 In-house 8-272 (273) alignment 
Range on Protein: 258-581
Range on HMM: 8-272/273.0
SMEKTGISEEFDRLSQEALpaeqYLSKREGRRPVNAEKNRYKNIVPFDHTRVILtdrpNTPGSDYINASYVRFEnsqrtknvtfACEKSFIATQGCLETT
.  .|.. |||..| .       .|... ...| | .|||||.|.|.||.||.|    . .||||||||||..            ... |||||| |. |
llgltllleefelllslkp....lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgy..........nlkrkfiatqgPlpnt

ISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNK-PEVHGDISLTCTIERkvqravsdevkaeleqektnriakglvpeaelngDGISYILRTL
. ||| |||..|.||||| | . |. .||||.||| |... ....|... |.. |                                      .|..|||
vedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllsee..................................tkddytvrtl

VMKK--GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQpiaaslpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPMDVYKMV
 ...   ...|......|..|||||.| ..  .|.|.|.|.. . ... .        ||.|||||||.|||||...|| ||.|..| |    .||.. |
eltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn........gpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleav

KYVRTYRSGLVQTEQQYQFLYKALAFYL
|..|..| | |||..||.|||.||..||
kllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 261-583 8.3e-78 257.5 In-house 26-306 (307) alignment 
Range on Protein: 261-583
Range on HMM: 26-306/307.0
KTGISEEFDRLSQEALPAeqYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNT-PGSDYINASYVRFENSQRTKNVTFacEKSFIATQGCLETTIS
.||. .|| .| ..  .   . . .....|.| .|||||.|.|.|||||.|.. ... ..||||||||||. .   ..   .   . ||||||.|. |. 
ltgllkefekllsvtvfl..lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl..krkfIatqgPlpetve

DFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEvNKPEVHGDISLTCTierkvqravsdevkaeleqektnriakglvpeA-ELngdGISYILRTLVM
||| |.|.....|||| | . |. .||||.||| | . . ..|..  |..                                  |      .|..||| .
dFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtll................................seeh...ldgytvrtlev

K---KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYfnaqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVK
.   . . .|......|..|||||.| ..  .|.|.| |.. ..         . ..||..||||||.|||||..... .| |..| | |. .|... ||
tdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee........lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavk

YVRTYRSGLVQTEQQYQFLYKALAFYLKN
..|  |.| ||...||.|||.||...|..
llreqRpgavqnpeqyrflyeallelllk
0039614 (Phosphotyrosine protein) phosphatases II 257-586 1.1e-75 250.2 In-house 27-294 (297) alignment 
Range on Protein: 257-586
Range on HMM: 27-294/297.0
ESMEKTGISEEFDRLSQEALPaeqylsKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNT-PGSDYINASYVRFENSqrtknvtfaCEKSFIATQGCLE
  ..||.. .|| .| .   .      ......|.| .|||||.|.|.||.||.|.. ... ..||||||||| . .            . ||||||.|.
kansktllllefeellslkpd......ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydl.........ltrkfIatqgPlp

TTISDFWSMVWQENSRVIVMPTMENERKEKCARYWPAEVNkpeVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaelnGDGISYILRTL
 |. ||| |||.....|||| | ..|.. |||.||| |..   ..||.. |.. .                                       |..|||
etvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkv..................................ehldgytvrtl

VMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYKMVKY
 ..... .|.....||. |||||.| ..  .|.||| |.. . .          ..||..||||||.|||||..... .|.|..|    . .||.. ||.
evtnngesrtvthfqytgwpdhgvppslellleflelvrealael........pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavke

VRTYRSGLVQTEQQYQFLYKALAFYLKNNNP
.| .|.| |||..||.|||.||...||....
lreqRpgavqtpsqyrflydallellkrklt
0043336 (Phosphotyrosine protein) phosphatases II 260-581 7.7e-73 240.7 In-house 18-277 (278) alignment 
Range on Protein: 260-581
Range on HMM: 18-277/278.0
EKTGISEEFDRLSQEALpaeqyLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTIS
.||....|| .| .  |      ... ...| | .|||||.|.|.||.||.|.. .. ..|||||||||           .. . . ||||||.|. |. 
lktllllefeellsfkl.....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvd..........gynvprkfiatqgPlpetve

DFWSMVWQENSRVIVMPTMENERK-EKCARYWPaevNKPEVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaelnGDGISYILRTLVMK
||| |||......||| | . |.. .|||.|||   ......||.. |.. |                                       |..||| ..
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllke..................................ehlddytvrtlevt

--KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDyfnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPMDVYKMVKYV
  . . .|......|| |||||.| ..  .|.||..|.. ..           ..||..||||||.|||||...|. ||.|..| |    .|... ||..
nlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale..........dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkel

RTYRSGLVQTEQQYQFLYKALAFYL
|..| | |||..||.|||.||..||
reqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 292-578 6.3e-71 233.9 Pfam-A 1-234 (235) alignment 
Range on Protein: 292-578
Range on HMM: 1-234/235.0
NAEKNRYKNIVPFDHTRVILtdrPNTPG-SDYINASYVrfensqrtK---NvtfacEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKC
| .|||||.|.|.|.||| |    ...| ||||||.||        |   .     .|.||||||.|. ||.||| |||||...|||| | ..|. .|||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv........kgyke.....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekc

ARYWPAEVNKPEVHGDISLTCTieR----KVQRAVSDEVKAELEQEKTnriakglvpeaelngdgisyilrtlvmkkgkDTREIRQLQYLTWPDHGCPLH
|.||| | .... .|||.....       . .. .  ... . ..|..                               ..||..||.| .|||||.| .
aqYwpeeeeesltygdikvelk..ekekedekeytlrklelkkkkees...............................ekrevkqlhytnWpdhgvpes

PYAVLNFLEDVDREYdyfnaqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALA
| ..|.....| ..           .  .||.|||||||.|||||...||.||.|... .    .||...|| .|. | |.||...||.|||||..
pkslldlirkveksk..........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 292-578 6.3e-71 233.9 In-house 1-234 (235) alignment 
Range on Protein: 292-578
Range on HMM: 1-234/235.0
NAEKNRYKNIVPFDHTRVILtdrPNTPG-SDYINASYVrfensqrtK---NvtfacEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKC
| .|||||.|.|.|.||| |    ...| ||||||.||        |   .     .|.||||||.|. ||.||| |||||...|||| | ..|. .|||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv........kgyke.....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekc

ARYWPAEVNKPEVHGDISLTCTieR----KVQRAVSDEVKAELEQEKTnriakglvpeaelngdgisyilrtlvmkkgkDTREIRQLQYLTWPDHGCPLH
|.||| | .... .|||.....       . .. .  ... . ..|..                               ..||..||.| .|||||.| .
aqYwpeeeeesltygdikvelk..ekekedekeytlrklelkkkkees...............................ekrevkqlhytnWpdhgvpes

PYAVLNFLEDVDREYdyfnaqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALA
| ..|.....| ..           .  .||.|||||||.|||||...||.||.|... .    .||...|| .|. | |.||...||.|||||..
pkslldlirkveksk..........eaksgpvvVhCsaGvgRtgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0040439 (Phosphotyrosine protein) phosphatases II 285-583 3.9e-70 231.6 In-house 4-248 (249) alignment 
Range on Protein: 285-583
Range on HMM: 4-248/249.0
REGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSQRtknvtfacekSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-K
.....|.| .||||..|.|.||.||.|.. |. ..||||||||. . ...|           ||||||.|. |..||| |.|.....|||| | . |. .
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikr..........rfiatqgPlpetvedfwrmlwelgitvivmLtslvelgr

EKCARYWPAevNKPEVHGDISLTCTierkvqravsdevkaeleqektnriakglvpEAELNGDgisYILRTLVMK--KGKDTREIRQLQYLTWPDHGCPL
||||.|||   ... ..||.. |..                               . | ..|   |..||| ..  . ...|.....||. |||||.| 
ekcaqywpl..ggsleygdftvtll...............................svevkdd...ytvrtleltnlydgesrtvlhiqytdwpdhgvpp

HPYAVLNFLEDVDREYDYFnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL
..  .|.|.| |.  ...          ..||..||||||.|||||..... .|.|..|    . .|..  ||..|..|.| ||...||.|||.||...|
sfedlldfieavrkaleel........pkggpvlVHCsaGvgRtGtfiaaylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell

KN
..
lk
subfamily_PTPRG_pd Subfamily PTPRG 260-581 2.1e-67 222.6 In-house 17-287 (563) alignment 
Range on Protein: 260-581
Range on HMM: 17-287/563.0
EKTGISEEFDRLSQEALPaeQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGS-DYINASYVRfensqrtknvTFACEKSFIATQGCLETTI
...|.||||. | .|  .  ..|     ..| | .|||| |||..|..|| |.. |.. .. |||||.|.            .  .| |||||| |..|.
gdigfseefealqsetis..kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid..........Gyqkskafiatqgplkdtf

SDFWSMVWQENSRVIVMPTM-ENERKEKCARYWPAevNKPEVHGDISLTCTIERKVqRAVSDEvkaeleqektnriakglvpeaelngdgiSYILRTLVM
 ||| |.|..|. .||| |  ... ..|| .|||.  ...|  | ...| . | ..    . .                            . ... | .
ddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevl.alytvr............................tlviknlkl

KKGKD---TREIRQLQYLTWPDHGCPLHPYAVLNFLEDVdreydyfnaqpiAAS--LPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKM
||.|.    ...|| .| .||||| | |.  ||.| .              .|.     ||||||||||.||||| .|||.||.|...      ..|...
kkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks............saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgf

VKYVRTYRSGLVQTEQQYQFLYKALAFYL
.| .|. |  ||||| ||.||..||   .
lkhiraqRnflvqteEqYiflhdalleai
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 256-585 2.5e-67 222.2 In-house 21-294 (298) alignment 
Range on Protein: 256-585
Range on HMM: 21-294/298.0
RESMEKTGISEEFDRLSQEALpAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfenS---QRtknvtfacekSFIATQG
..... || ..|| ||..      .  .|. .|.| | .|||| .|...|..||.|..  .   |||||||..    .   .           .|||||.
kkkkkltgyalefqrlnsvss.eieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh...aykgrn..........afiatqa

CLETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEvnKPEVHGDISLtctierkvqravsdevkaeleqektnriakgLVPEAELNGDgisYI
 |..|..||| ||..|.. .||| |  .|  | |. .||| |  . | .|.|..                                . . |  .|   .|
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv...............................sllskeefad...li

LRTLVMK--KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReYDYFNAqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDV
 |.| ..  | ...||.|||.. .|||.| | .  .||..|..| . . . .         . |..|.||||.||.||  ..|..|..|||      .||
vrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqag........nkpvivqCsaGvgRsGtfiaidsvlervkkeqv...vDv

YKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNN
...||..|. | |.||||.|| |.|.|   .|.  |
fqvvkvlRkkrpgavqteeqYvfiyeavlealdsfn
0045098 (Phosphotyrosine protein) phosphatases II 275-585 5.9e-67 221.3 In-house 16-276 (278) alignment 
Range on Protein: 275-585
Range on HMM: 16-276/278.0
ALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVIltdrpntpgsDYINASYVRFEnsqrtKnvtfaceKSFIATQGCLETTISDFWSMVWQENSRVIV
 |.  .  .  .. .. |..|||||.|.|.||.||.          |||||||...      .       | ||||||.|..|..||| |.|.....|||
llllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.....p.......kkfIatqgPlpstvadfwrmlwelgitviv

MPTMENER-KEKCARYWPaEvNKPEVHGDISLTCTIErkvqravsdevkaeleqektnriakglvpeaELNgdgISYILRTLVMK------KGKDTREIR
| | . |. .||||.||| | ......||...|.. |                               | .     |.|||| .       ..  .|...
mltelvelgrekcaqywp.e.ggsltygdftvtllse...............................evl...ddytlrtllvtnltveredlesrgvt

QLQYLTWPDHGCPLHP--YAVLNFLEDVDREYDYFNAQPIAASL---PQGPIVVHCSAGIGRTGTVLVLDALLNQVkkvGllCPMDVYKMVKYVRTYRSG
.|.||.|||||.| .|    .|..|| ... ..... . .   |   ..||..||||||.|||||. ... .| ..   .  . .|... ||..|..| |
hlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell...e..ggvdlleavkelrsqRpg

-LVQTEQQYQFLYKALAFYLKNNN
  ||...||.|||..|. .|....
lavqnleqyrflyefllelllrgk
0042113 (Phosphotyrosine protein) phosphatases II 286-582 1.2e-66 219.9 In-house 3-244 (245) alignment 
Range on Protein: 286-582
Range on HMM: 3-244/245.0
EGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfensqrtknVTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERK-E
 ...|.| .||||..|.|.|||||.|.. .. ..|||||||||           .. . . |||||| |. |. ||| |.|......||| | | |.. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..........dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrv

KCARYWPAevNKPEVHGDISLTCTIERkvqravsdevkaeleqektnriakglvpeaelngDGISYILRTLVMK--KGKDTREIRQLQYLTWPDHGCPLH
|||.|||   . . ..||.. |.. |                                      .|..||| ..  . . .||.....|| |||||.| .
kcaqywpl..gesltygdftvtllsee..................................hlddytvrtlevtnlgddesrevihyhylpwpdhgvpdl

PYAVLNFLEDVDREYDYfnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
.  .|.||| |.. .            ..||..||||||.|||||..... .|.|..|    . ..... ||..| .|.| |||..||.|||.||...||
lellldflefvrkalae.........dsngpvlVHCsaGvgRtGtfiaaylmleqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 286-581 5.5e-64 211.3 In-house 4-242 (243) alignment 
Range on Protein: 286-581
Range on HMM: 4-242/243.0
EGRRPVNAEKNRYKNIVPFDHTRVILtdrpntPGSDYINASYVRFENsqrtknvtfacekSFIATQGCLETTISD----FWSMVWQENSRVIVMPTMENE
 ...|.| .||||..|.|.||.||.|      .|||||||....  .              .||||| |. |. |    || |.|.....|||| | . |
iallpenlsknrysdilpydhsrvkl......egsdyinanliyvtp.............rliatqgPlpetveddlasfwrmlwelgitvivmltelvE

R-KEKCARYWPaevNKPeVHGDISLTCTIERkvqravsdevkaeleqektnriakglvpeaelngDGISYILRTLVMKK---GKDTREIRQLQYLTWPDH
. .||||.|||   ..  ..||.. |.. |.                                   . .|..|||...    .. ||......|| ||||
lgrekcaqywp...gev.tygdftvtllsee..................................hlddytvrtlllenldlddltrlvihyhylpwpdh

GCPLHPYAVLNFLEDVDREYDYFNaqPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVkkvgllcPMDVYKMVKYVRTYRSG-LVQTEQQYQFLYKA
|.| .|  .|.||..|   .. ..  .. |  ..||..||||||.|||||..... .| ..        .|... ||..|. |.|  |||..||.|||.|
gvPdspedlldfldevrefieell..sllaldsggpvlVHCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyea

LAFYL
|...|
llell
subfamily_Ptp69D_pd Subfamily Ptp69D 260-583 3.7e-62 205.2 In-house 20-288 (307) alignment 
Range on Protein: 260-583
Range on HMM: 20-288/307.0
EKTGISEEFDRLSQEalpaEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTIS
 . |. .|...| ..    |  .| . . .  || ||||..|..||.|||.|.  . .  |||||||...          ..  .|.||| |. .|.|| 
tdfglakeyekLear....eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik..........gykekkkfiaaqdPveatig

DFWSMVWQENSRVIVMPTMENERKE-KCARYWPAEvnKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIakglvpeaelngdgisyilrtlvmk
||| |... .. .||| . ..| .. |||.||| |  .   .|||  ..  |.| .  .  |..    .|... .                         
DfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgev.........................

kgKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPMDVYKMVKYVRT
  .|.|.. | .|..|.|   | .. ..|...| |   |             ..||||||||| ||.|... || ||.|.|.      .|....|| .| 
..edsrkvvqyhytgWkDskvPevargllklieqvrelykln..........rsPivvhCsaGvgrsgifvaldsllqqlkaed...kvdifetvkdLrs

YRSGLVQTEQQYQFLYKALAFYLKN
 |. |||  .||.|||.||. | . 
qRnllvqsleqYvflyralldyssy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 283-583 4.7e-61 201.3 In-house 19-270 (274) alignment 
Range on Protein: 283-583
Range on HMM: 19-270/274.0
SKREGRRPVNAEKNRYKNIVPFDHTRVIL-TDRPNTPGSDYINASYVRFENSQrtknvtfacEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENE
...| . . ...|||||.|.| ...||.| .. .. . |.|||| |..  . .         .| ..|||| | .|..||| |..||...|||| |  .|
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydee.........skayvatqGPlpntvadfWrmiyqeevqvivmltklke

RKE-KCARYWPAEVNK--PEVHGDISltctierkvqravsdevkaeleqektnriakglVPEAELNGdGISYILRTLVMKKGKDTREIRQLQYLTWPDHG
..| |||.|.| . .    | .||..                                 .   . .     | .|.||.|. ...|..    |  |||| 
aneqkCavyfPdaedyeiserygdve.................................ikvekive.rndysvrklvlkylerersvkhywytdWPdhk

CPLHPYAVLNFLEDVdreydyfNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALA
 | .. ..|.....|       . .  ... . .|.||||||||||||  .  .  ..|... .    .|| |.|  .|  | |.|||..||.....||.
sPddantlldlvlev.......eesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeiv...vdvlkivcnlrldrGGmvqtseqyelihralc

FYLKN
 |||.
lylkr
subfamily_PTPN1_pd Subfamily PTPN1 278-577 7.7e-58 190.5 In-house 18-267 (290) alignment 
Range on Protein: 278-577
Range on HMM: 18-267/290.0
AEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNtpgsDYINASYVRFENSQRtknvtfacekSFIATQGCLETTISDFWSMVWQENSRVIVMPT
  . .. || ..| | ..|||... |.||.|..| .  |    |||||| | .|. .|          |.| ||| |  |.. || |||...|. .||  
easdfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakr..........syiltqGPlpntvdhfWqmvWeqkskavvmln

--MENErKEKCARYWPAEVNKPEVHGD-ISLTCTIERKVQRAVSDEVKAELEQektnriakglvpeaelngdgisyilrtlvmKKGKDTREIRQLQYLTW
  .|.| . |||.||| . .. |.  . ..|. .. .. ..      . |||.                              .| ..|||| .  |.||
kvveke.qikcaqywPqgeeekellledtklkvkliseerksyytvrllelen..............................lktqetreilhfhyttw

PDHGCPLHPYAVLNFLEDVdREYDYFNAQpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVYKMVKYVRTYRSGLVQTEQQYQFLY
|| | |  | | |.|| .| ||   .. .       .|| |.||||||||.||. ..|..| ...| . |  .|. |..  .| || ||.|| .| .| |
pdfgvpespaaflkflfkv.resGslssd.......vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsy

KAL
 |.
lai
subfamily_PTPRK_pd Subfamily PTPRK 288-577 3.3e-55 182.1 In-house 39-273 (314) alignment 
Range on Protein: 288-577
Range on HMM: 39-273/314.0
RRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfensqrtknVTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPT-MENERKEKC
..  | ||||...|...|..||.|.   . | ||||||...           ..   . ||.||| |. |. ||| .|..||.  ||| | . .. . ||
kkdenreknrsgdilaydrsrvflitidgdpssdyinaali..........dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkC

ARYWPAEVNKpevHGDISLTCTIERKVQRAVSDEVKAELeqektnriakglvpeaelngdgisyilrtlVMKKGKDTREIRQLQYLTWPDHGCPLHPYAV
 .||| . ..   .||| ...      .  |.   . |                               . .. ...||.||.|.|.||||. | .  ..
lkyWPedtev...ygdikvelvetellaelvvrifrvek..............................largqeeirevrqfqflgWpdhdvPvsatgl

LNFLEDVDREYDYfnaqpiaaslPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKAL
|...  |.   .            .|.|||||||| ||||| ...| .|. ... |.   .||...|| .|.... .|.||.||.|.| ..
lklvrrvkksqee..........eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 260-577 7.5e-51 168.3 In-house 32-287 (319) alignment 
Range on Protein: 260-577
Range on HMM: 32-287/319.0
EKTGISEEFDRLSQEALPAEQylsKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfeN-SQRtKNvtfacekSFIATQGCLETTI
..| .  || |... . .  .   .     . | .|||. ||..||...| |       .|||||||.|   .  || |.        .||.|| |. |.
dltklevefrracklgvnlad...qtfanldqnkdknriinilafdknvvklerliGeefsdyinasfv...tGyqr.kd.......kyiaaqGPldntl

SDFWSMVWQENSRVIVMPTmenerKEKCARYWPAEVNKPEVHGDISLTCTIERKVqravsdevkaeleqektnriakglvpeaelngdgisYILRTLVMK
 ||| |.|. |.  ||. |     |.||..||| .... | .......   | .                                     |..| . . 
adfWrmiweyncstivllt.....kdkcsqywplkivikeerfkvkvdsveetae....................................yvvrdiels

K---GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKY
.    || |.|.|  .| |||.| | .|  .. ... |    .  |         . .||||||||.||||. .|||.||...|.      .|||..|. 
edgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenh........ranivvhcsaGvGrtGvyivldvlldrmkeekq...vdvynfvrd

VRTYRSGLVQTEQQYQFLYKAL
.|  |. |||   ||.|.| ||
lrqqrntlvqdlvqykfiysal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 292-583 2.7e-50 165.9 In-house 20-266 (270) alignment 
Range on Protein: 292-583
Range on HMM: 20-266/270.0
NAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknVTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPT-MENERKEKCARYW
... |||..|.|  .|||.| .  ... . |||| |||              .|..||..| |.||...|| |.|.|... ||| | .|.. ..||.|||
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr.........GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYW

PAevnkpevhgdisltctierkvqravsdevkaelEQEKTNRIAKGLVPEAE-LNGDGISYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPY-----
||                                 |.... ....| .  .   .     |||. | ...  ..|..   .| |||||| | ..      
pa.................................epkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslst

-AVLNFLEDVDREYDYFNAQpiaaslpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKN
  .|. |..| |  . .. .        .|..||||||.|||||...||  .. ... .    .|| .... .| .|  |||. .||.|||||.. | . 
dqllkmlravrrsekeldka........ePllvHcsaGvgRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 275-594 6.9e-48 158.0 In-house 28-250 (392) alignment 
Range on Protein: 275-594
Range on HMM: 28-250/392.0
ALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIV
 ||  .   .. .....| .|||||||.|.| .||.|    ..| |||.||||..          .| .||..||.||   ....|||.||.|||   |.
dlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip..........sfdnekayiasqgpnaaslddfwrmvfqenvttia

MPTMENERKekcarywpaevnkpevhgdisltctierkvqravsdevkaeleqektnriakglvpeaelngdgisyilrtlvmkKGKDTREIRQLQYLTW
| |  .|                                                                             ||.|.| . | ..  |
mvtklkegd...........................................................................kgddartvaqfhftew

PDHGCPLHPYAVLNFLEDVDREYDYFNAqpiaaslpqgPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLY
||.. | |  ..|.|...|  ..  .            |...|||||.|||| |. .|... . ||. .   .||...|  .|  |  .|||..|| |.|
PdkdvpkhtssllkfikevkadfGqyth..........pliihcsagvgrtgvvisidsvvahakktrm...vdvfnfvtnirrkrpymvqtkeqyafiy

KALA-FYLKNNNPYPVKSFID
 |.    |  |   ||  | |
gavledllwrntlipvvhftd
0041856 (Phosphotyrosine protein) phosphatases II 292-586 4.7e-47 155.3 In-house 1-176 (182) alignment 
Range on Protein: 292-586
Range on HMM: 1-176/182.0
NAEKNRYKNIVPFDHTRviltdrpntpGSDYINASYVRFENSQRTknvtfaceksFIATQGCLETTISDFWSMVWQENSRVIVMPTmenerkekCARYWP
| .||||..|.|.||.|          ..|||||.....   ...          |||||| |  |. ||. |..... ..||. |        . .|||
nldknrysdilpydhsr..........dldyInanlylgslpatr..........fiatqgpllstvadflrmlkelgittivnlt........eelywp

aevnkpevhgdisltctierkvqravsdevkaeleQ-EktnriakglvpeaelngdgisyilrtlvmkkgkdTREIRQLQYLTWPDHGCPLhPYAVLNFL
                                   . .                                  .|.. |..|| |||||.|  .. .|.|.
...................................ell..................................erlgiqylylpwpDhgvpd.ldelldfi

EDVDReydyfnaqpiaaslPQGPIVVHCSAGIGRTGTVLVLDALLNQvkkvgllcPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNP
|.| .              ..||..||||||.|||||. ... .. .         ..... ||.|| .|.| |.|..||.||. || ..|.... 
eevle..............eggpvlVHCsaGvgRtgtlvaaylmkkl........gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 260-585 6.3e-47 154.8 In-house 18-287 (290) alignment 
Range on Protein: 260-585
Range on HMM: 18-287/290.0
EKTGISEEFDRLSQealpAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPG--SDYINASYVRfensqrtknvTFACEKSFIATQGCLETT
 ..|  ..| .| .    .|.  .   |  . | ..||..|||. |  |..| . .. .    .||||.|.            .  .|..||||| .. |
gnegfrnqfkmlds....gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik..........gykekkqyiatqgpvsnt

ISDFWSMVWQENSRVIVMPTMENE-RKEKCARYWPAEvNKPEvHGDISLTCtierkvqravsdevkaeleqektnriakglVPEAELNgDGISYILRTLV
. |||...|||.. .||| | ..|  |.||  |||.. .  .  | .|..                               . | .|| . |   |.   
lvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikl..............................lneetln.eyierklevkn

MKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDRE-YDYFnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKY
.......... |.|  .|...|   .| ..|  .| . .  .             ...||||||...||... ....  .|..|. |    .||....| 
knsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..........ntsivvHCSdtvgrsavfcaaattinkcktegv...idvfqvlks

VRTYRSGLVQTEQQYQFLYKALAFYLKNNN
 |. . |.|||.||||.... .  ||.. .
qRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 287-586 2.3e-45 149.6 In-house 35-298 (301) alignment 
Range on Protein: 287-586
Range on HMM: 35-298/301.0
GRRPVNAEKNRYKNIVPFDHTRVILTDRPN--TPGSDYINASYVRFENSQrtknvtfaceKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-K
| .  |.. ||.|||...|. |.||.  ||  .   .||||||.   ...          | |||.|| .. |. ||| ..|||    ||| | ..|. |
glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysek..........kkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtk

EKCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTnriakglvpeaelngdgISYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHP
.|| .|||   .. |  | .. | . |  .   |  ...  ...                     .|| |.. .|. |..... |||   ||..|    |
skceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsn.................ngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

YAVLNFLEDVdreydYFNAQPIAaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKN
  ||. ..||         | |      ||.|||||....|.|.   ..  | |.|  |     ||....| ||  . | |.| .|| ..|...  ||. 
rtvLqviddv.....ihrqqkig....ggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

NNP
|. 
nst
subfamily_CG7180_pd Subfamily CG7180 285-580 2.4e-44 146.2 In-house 35-289 (296) alignment 
Range on Protein: 285-580
Range on HMM: 35-289/296.0
REGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfeNsqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERKE
. | |  | ||||. ..||.|..||.|.       ||||||.||   .       .|  .| .| |..  . |. .||..|..|..  .|. | . . ..
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyv...d.......sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak

KCARYWPAEVnkPEVHGDISLTCTIERKVQRAVSDEVKAELEqektnriakglvpeaelngdgisyILRTLVMKKG--KDTREIRQLQYLTWPD-HGCPL
..  ||| .    | .|.| .  . |..    .. ..|   .                        |. .  ..|.   .|| ....|. .|.  . .||
mypsywpnks..keqygeifveiveekqyanlkirtfkltkk........................ivalteqekqvkaetRivklfqlteWeledkvPl

HPYAVLNFLEDVDREYDYFnaqpiAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFY
   |...... |    .            .||.||..| | .|.|  | .|| |..|.| .    .||...|| .|  | .||.. ..|...|  |  .
stnalielrrrvrlwrekv.....dedpeegPvvvvssdGasRsGvylaidanlelvekeee...vdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 294-581 5.9e-43 141.9 In-house 49-344 (350) alignment 
Range on Protein: 294-581
Range on HMM: 49-344/350.0
EKNRYKNIVPFDHTRVILTDRPN--------TPGSDYINASYVRFENSQRTKNVTFacekSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KE
 |||||||.|..|.||.|   ..        . ..|||||.|.. .      |  |     .||||. |  |. ||. .. . . .||.. | . |   |
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf....kYiatqaPlpstvddfykvillnkvkvilsltsdvelnle

KCARYWPAeVNKPEVHgdISLTCTIERKVQRAVSDEVKAELEQEKTNRIAKGLVPEAELNGDGISyilrtlVMKKGKDTREIRQLQYLTWPDHGCPLHPY
|| |||.   .  ...  . |. . |  .    |    |....| ..   .  . . . |.. ..      .     |  .. |||.  |.| .  |.| 
kcyrYWqe.gsyddit..vklaskwenimgindsslysadvkkeasdndnisddndlkdnnslta......itlaasdPyvvyqlqvknWkDlslllnPe

AVLNFLEDVDREYDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQV----------KKVGLLCP-MD-VYKMVKYVRTYRSGLVQTEQQYQF
 .|. ||  .   |  .|.    .  . ||.||||||.|||||.. || ||...          .|.       | .  .|. .|  |  .||. .|. |
silqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfif

LYKALAFYL
.|.|| || 
iYeallfyf
0049772 (Phosphotyrosine protein) phosphatases II 285-584 4.4e-42 140.3 In-house 39-283 (314) alignment 
Range on Protein: 285-584
Range on HMM: 39-283/314.0
REGRRPVNAEKNRYKNIVPFDhTRVILtDRPNTPGSDYINASYVRFEnsqrtknvtfaceKSFIATQGCLETTISDF----------WSMV--WQENSRV
  .. ..| .||||..|.|.| .|||| .. .  ||||||||||.               ..|||||| || |. ||          |.||  .. |.|.
lvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.............lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IVM-----------------------PTMENErkekcaR-----YWPAEVnkpevhgdisltctierkvqravsdevkaeleqektnriA-------Kgl
|||                       . ..|             ...                                                     
ivmsrdevladelsrLdaAlgKtpllildgng......neptaadlellk.......................................eelydpelf..

vpeaelngdgisyilrtlvmkkgkdTREIRQLQYLTWPDHGCPLHPYaVLNFLEDVDREyDyfnaqpiaaslPQGPIVVHCSAGIGRTGT-VLVLDALLN
                         .|.. .. .. .||...||  . .. ||| ...  |           ..||..|||.||.||||| |..   .. 
.........................erlgikylripvpDgsaplled.fdeflefieea.d...........kggpvlvHCkaGkgRtgtfvvaaylmkl

QvKkvgllcpMDVYKMVKYVRTYRS-----GLVQTEQQYQFLYKALAFYLKNN
. .       ... . ...||  |.     |.... .||.| ..||  |||. 
l.g.......vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 256-429 2.9e-39 129.9 In-house 15-172 (288) alignment 
Range on Protein: 256-429
Range on HMM: 15-172/288.0
RESMEKTGISEEFDRLsqeaLPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSqrtknvtfacEKSFIATQGCLE
 . ...||.|||.. |     . |.  |.  ||..|||.||||.||.|.|..|| |.. ....|.|||||||.  |..          .| .||||| | 
ksarnrtgfseeynsL....aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk..........kkkyiatqgPla

TTISDFWSMVWQENSRVIVMPT-MENERKEKCARYWPAEvNKPEVHGDISLTCTIERKVQRAVSDEVKAEleQEK
 |. ||| .|.....  ||| | . .. |.|| .|||.. .||. .|.. .| . .....  |  ..  |  ..|
dtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 260-434 3e-39 130.0 In-house 18-177 (318) alignment 
Range on Protein: 260-434
Range on HMM: 18-177/318.0
EKTGISEEFDRLSQEalpaEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSQrtknvtfaceKSFIATQGCLETTIS
 .. .|||..|||..    |.  .. .   |||. |||| ||...||||| |... ...|||||||.|.   ...          |..||.|. |  ||.
Gelllseeyerlsrs....eetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrk..........kayiaaqaPlpetie

DFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEvnKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIA
||| |||. ||.|||| | |.|| |.|..|||| .  ... .|..  . . | ...  |  |.| . ..|. .|. 
DfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqv
0043147 (Phosphotyrosine protein) phosphatases II 318-575 1.3e-38 127.8 In-house 3-155 (172) alignment 
Range on Protein: 318-575
Range on HMM: 3-155/172.0
PGSDYINASYVRFENsqrtknvtfaCEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTmENerkekcarywpaevnkpevhgdisltctierkvqrav
.|||||||||. .            . ..||||||.|  |..||| |..... ..||. | |                                      
egsdyinasyldlyy..........ipdrfiatqgplrntladfwrmlkelgithivnlt.el.....................................

sdevkaeleqektnriakglvpeaelngdgisyilrtlVMKKGKDTREIRQLQYLTWPDHGCPlHPYAVLNFLEDVDREYdyfnaqpiaASLPQGPIVVH
                                      .  . . .|.. |..|| |||||.| ..  .|.||| .|. .         |  |.||..||
......................................lydpellerlgiqylylpwpDhgvp.llellleflefidell.........alspggpvlVH

CSAGIGRTGTVLVLDALLnqvkkvgllCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYK
||||.|||||. ... .|         . ..... |..||. |.| ||...||.|||.
CsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnpsqyrflyy
0036282 (Phosphotyrosine protein) phosphatases II 319-575 3.1e-38 126.5 In-house 1-164 (174) alignment 
Range on Protein: 319-575
Range on HMM: 1-164/174.0
GSDYINASYVRFENSQRtknvtfacekSFIATQGCLEttisdFWSMVWQENSRVIVMPTMENERK-EKCARYWPAevnkpevhgdisltctierkvqrav
||||||||.. .    .           .||.||.|.     || |.........|| . |.|.. .|| .|||                          
gsdyinaspldlsyitp..........rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.........................

sdevkaeleqektnriakglvpeaelngdgisyilrtlvmKKGKDTREIRQLQYLTWPDHGCPLHPYaVLNFLEDVDREYdyfnaqpiaASLPQGPIVVH
                                        ..   .|.. |..|| |||||.|  .  .|.|.. |.. .         .. |.||..||
........................................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.........sedpggpvlVH

CSAGIGRTGTVLVLDALLNQVKkvglLCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYK
||||.|||||. ... .| . .      ..|....|. .|..|.| |||..||.|||.
CsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_PTPRB_pd Subfamily PTPRB 260-429 2e-37 123.8 In-house 23-178 (293) alignment 
Range on Protein: 260-429
Range on HMM: 23-178/293.0
EKTGISEEFDRLSQealpAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSQRtknvtfacekSFIATQGCLETTIS
.....|||...|..     ..  ..   ...||..||||.||.|.||.|| |..  ...|||||||.|..  ||.|           |||||| | .|. 
sdlrfseeyeelka....vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr..........efiatqGPlpetvd

DFWSMVWQENSRVIVMPTMENE-RKEKCARYWPAEvNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEK
||| |||...|..||| |   | .|.|| .||||. ..| ..|||..| . |....  |  |.| | |.|.
dfWrmvwekkssiivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaeeeledwvirelkiekekee
0051429 (Phosphotyrosine protein) phosphatases II 318-583 4.7e-37 123.5 In-house 2-227 (272) alignment 
Range on Protein: 318-583
Range on HMM: 2-227/272.0
PGSDYINASYVRFEnsqrtknVTFACEKSFIATQGCLETTISDFWSMvWQENSRVIVMPTMENERK-EKCARYWPaevnkpevhgdisltctierkvqra
| |.||||..|               .. .....|.|. |. ||| . .... ..||. . |.||. .|| ||||                         
plsgyiNardvggy.......grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywp.........................

vsdevkaeleqektnriakglvpeaelngdGI-------------------------------SYILRTLVMK---KGKDTREIRQLQYLTWPDHGCPLH
                              ||                                ||||.|...   . ...||...|.|. ||||| | .
..............................girylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqe

PyaVLNFLEDVDReydyfnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLnqvKKVGLLCPMD--------VYKMVKYVRTYRSGLVQTEQQYQFLY
.  .|..|| . .               .||..||||||..||||| .|. ||     |.| . .|        ... |...| .| | ||||.||.|||
a..llellellld...............ggpvlvHCsaGkdRTGtvvalllll...lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

KALAFYLKN
.||. .|..
eallellrs
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 268-576 5.1e-37 122.3 In-house 15-261 (283) alignment 
Range on Protein: 268-576
Range on HMM: 15-261/283.0
FDRLSQEALPAEQYLSKRegrrpvNAEKNRYKNIVPFDHTRVILTDRPNtpgsDYINASYVRFensqrtkNVTFACEKSFIATQGCLETTISDFWSMVWQ
..|||   |.|.   ...      | .|||...||| |  || |   ..    |||||...         .     .| .|..|. |. |. ||| ||..
lkrlsvpdldadiasade......nkrknrnqeivpadqwrvelksesr....dyinavfipv.......sksykqdkkyiiaqsPldrtvvdfWkmvfd

ENSRVIVMPT-MENERKEKCARYWPAEVNkpEVHGDISLTCTIERKVQRAVSDEVKAELEqektnriakglvpeaelngdgisyilrtlvmKKGKDTREI
|.   ||| | . .. ..||..||| .    | .|.  .|   |   .  .  |.    .                                  |.|  .
ekitaivmltklqedlrikCsqyWPkrGs..edyGeftvtlrkettsnsfiikelllrvn...............................ssakstlll

RQLQYLTWpdhgCPLHPYAVLNFLEDVDReydyfnAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQT
   |.  |        . |..| |  ...       .      ..||||||||.|||||.. . . | .....   .   .||...|| .|  | ..|||
ahyqvidW....leygeqaiinslvkfnk......vislqteskkgPivvhCstgiGrtavfiaasasvkdaltesv...vdvfavvkimreqrmmavqt

EQQYQFLYKA
 .||......
ldqyklvhel
subfamily_PTPN12_pd Subfamily PTPN12 263-415 5e-36 119.1 In-house 9-154 (290) alignment 
Range on Protein: 263-415
Range on HMM: 9-154/290.0
GISEEFDRLS--QEALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSQrtknvtfaceKSFIATQGCLETTISD
  ..|| .|   .|.. ||.  |. .|....| .|||||.|.|.|..|| |.   ...|||||||....  ...          ...||.|| | .|..|
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegk..........leyiaaqgPLpktldd

FWSMVWQENSRVIVMPTMENE-RKEKCARYWPAEVNKPEVHGDISLTCTIERKVQR
|| |.|. | ...||  .| |  | ||.|||| |....  .|....|.. |..|. 
fWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdd
subfamily_PTPN23_pd Subfamily PTPN23 260-431 5.8e-36 118.8 In-house 13-170 (288) alignment 
Range on Protein: 260-431
Range on HMM: 13-170/288.0
EKTGISEEFDRLSQEALPAEQYLSKREGRrpVNAEKNRYKNIVPFDHTRVILTdrpnTPGSDYINASYVrfensqrtKNVTFACEkSFIATQGCLETTIS
.||.. ..|  | |.     .  |    .  ...||||...|.|.||.|| |         ||||||.|        |...  |  .|||||. |..|..
gktaldkkfkeleqkqdkearkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfv........kdlspgcP.dfiatqaPlqstln

DFWSMVWQENSRVIVMPTMENERKE-KCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTN
|||.||... |.|||| . ..|... |..||||.. ......||.|.|.  .|. .  |  ..| | ..... 
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadav
subfamily_PTPN9_pd Subfamily PTPN9 258-417 5e-35 116.0 In-house 12-157 (297) alignment 
Range on Protein: 258-417
Range on HMM: 12-157/297.0
SMEKTGISEEFDRLSQEALPAEQYLSkregRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfeNSQRTKnvtfaceKSFIATQGCLETT
...| |.|.|.  . .|.   . . |    . ..| |||||.... .|.||| |. ..... ||||||..|   .  . |       |.|||||| |. |
ekgkrGlskeyaeirnepveGtflas....klranleknrytdvlcydetrvvlakvdedeasdyinanfv...dGykqk.......kafiatqGplkkt

ISDFWSMVWQENSRVIVMPTMENE-RKEKCARYWPAEVNKPEVHGDISLTcTIERKVQRAV
.|||| |||... .|||| |   | .. ||..||| | .. . .||.|.. ..| ..... 
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvs.nveveeeedy
0049260 (Phosphotyrosine protein) phosphatases II 345-575 6e-35 115.5 In-house 9-144 (152) alignment 
Range on Protein: 345-575
Range on HMM: 9-144/152.0
KSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWpaevnkpevhgdisltctierkvqravsdevkaeleqektnriakglvpeael
. ||||||... |..||| |... . ..||| | . |. |.||..|.                                                     
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.....................................................

ngdgisyilrtlvmkkgkdtreirQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfnaqpiaASLPQGPIVVHCSAGIGRTGTVLVLDALLnqvkkvgl
                        | ..| |||||.| ..  .| .|. ...           |  ..||..||||||.|||||. ... .|        
........................qylhlpwpDhgvpdlsqlllflllfiekl..........aldkggpvlVHCsaGvgRtgtlvaaylml........

lCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYK
 . ..... |..||. |.| |....|..|||.
.lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_PTPN12_pd Subfamily PTPN12 446-582 4.2e-34 112.8 In-house 155-278 (290) alignment 
Range on Protein: 446-582
Range on HMM: 155-278/290.0
DgisYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDyfnaqpiaasLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLC
|   ...||| ... |..|...|..|  |||||.|  .  .|...|.| .  .            . |.|||||||.|||||....|   ...|.  .  
d...flirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..........sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipe

PMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
 .||...|  .|. |. ||||..||...|||.| ...
eldvfdlvlelrkqraalvqtkeqyelvykavaelvq
0046846 (Phosphotyrosine protein) phosphatases II 317-583 6.8e-34 112.5 In-house 9-175 (176) alignment 
Range on Protein: 317-583
Range on HMM: 9-175/176.0
TPGSDYINASYVRFEnsqRtknvtfaceksFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERKE-KCARYWPAEVNKPEvhgdisltctierkvqr
 ...|||||...      |           .||||| |. |. ||. |..... ...|. | | | .  ||..||| . .                    
dldldyinanlilgs...r...........piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.................

avsdevkaeleqektnriakglvpeaelngdgisyilrtlvmkkgkdtreirQLQYLTWPDHGCPLHpYAVLNFLEDVDREYDYfnaqPiaaslpqGPIV
                                                    | ..| |||||.| .  ..|..|| ... ..             ||..
....................................................qylhlpwpDhgvpdl.elllellefirealke....g.......gpvl

VHCSAGIGRTGTVLVLDALLNQvkkvgllCPMDVYKMVKYVRTYRS-GLVQTEQQYQFLYKALAFYLKN
||||||||||||..... |  .       . ..|.. ...|| .|. | |||..||.|||... ..||.
VHCsaGigRtgtlvaayllele.......kglsveealalvreqRplgavqtpeQyrflyefellllkk
subfamily_PTPN3_pd Subfamily PTPN3 281-432 7.2e-34 112.0 In-house 30-171 (280) alignment 
Range on Protein: 281-432
Range on HMM: 30-171/280.0
YLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNtpgsDYINASYVRFENSQRTKNvtfaceKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMEN
 |.  . |.| |..||||..|.|.|.|||.|.. ..    |||||.|| .|    .        . .||||| |..| .||| |||...|..||| |   
glaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglv......nryiatqGPlaktatdfWqmvweqksslivmlttlv

ER-KEKCARYWPAEVNKPEvHGDISLTCTIERKVQRAVSDEVKAELEQEKTNR
|| . || .||| . .. | .|..|..|. |.. .  |  |.  . ...| .|
erGrvkChqyWPetedele.ygefsvkcekedetksyvlrelvlkdketkeer
0044763 (Phosphotyrosine protein) phosphatases II 303-587 3.7e-33 110.0 In-house 1-177 (178) alignment 
Range on Protein: 303-587
Range on HMM: 1-177/178.0
PFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvtfacEKSFIATQGClettiSDFWSMVWQENSRVIVMPTMENERK-EKCARYWPAEVNkpevhg
|.|.|||.|. ......|||||||..               .  .......     .|.. ...... ..||. | | |.  .|| .||| | .      
pldrtrvllsnleglersdyinaseil..............pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag......

disltctierkvqravsdevkaeleqektnriakglvpeaelngdgisyilrtlvmkkgkdtreiRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYdyfn
                                                                  | ... .||||.|  .  .|.|.| ... .    
.................................................................iqylhipipDhgvpdllehflefvefieeal....

aqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQvkkvgllcPMDVYKMVKYVRTYRSgLVQTEQQYQFLYKALAFYLKNNNPY
      . ..||..||||||.||.||. ... .. .         ..... ...|| .|.  |... |...||.   ..||.....
......dekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaielvrerRp.ivpnpgqlrqLyefelrllkesdll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 275-407 4.1e-33 109.5 In-house 27-150 (315) alignment 
Range on Protein: 275-407
Range on HMM: 27-150/315.0
ALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIV
 ||  .   .| .| ..| .|||||||.|.|..||.|    ..| ||||||||..          .. ..|..||.|| |.....|||.||.||.   ||
dlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik..........svdddkayiasqgPlkasvddfwrmvlqekvttiv

MPTMENERKE-KCARYWPAEVNKPEVHGDISLTC
| |  .|    ||..||| .  .    | |... 
mvtkkqegdkikcrqywPdrkadsvefGsikvel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 257-423 1.1e-32 108.3 In-house 18-168 (319) alignment 
Range on Protein: 257-423
Range on HMM: 18-168/319.0
ESMEKTGISEEFDRLSQEAlPAeqylSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLET
.|  .|.. .||  |..   .     . ..  .. | .||||.||...|.|||.|.. ....||||||||..           ..  .. |||||. ||.
astgetllekefkllkeav.nd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid..........gyqerekfiatqaPlen

TISDFWSMVWQENSRVIVMPTMENERKE-KCARYWPAEvnKPEVHGDISLTCTIERKVQRAVSDEVKA
||.||| |||.|.| ..|| |  .|. . |. .||| |  ..|. | . .|   |.. .  .  ..| 
tiedfWrmvWeeessivvmltklveklkvklkkywpee..nfeeyGrlivtleeeeeledyiirklkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 450-584 1.5e-32 107.9 In-house 161-286 (319) alignment 
Range on Protein: 450-584
Range on HMM: 161-286/319.0
YILRTLVMKK-GK--DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcp
|| | | ..|     .|||. . ||. ||||. | .  ..|..|... .  .  .         .||||||||||.||||| .|||| |..||. |.|  
yiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektq.........sgPivvhCsaGvGRtGtfivldamlervkeegvl..

mDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNN
 ||...|. .|| |  .||...||.|.|.||  ...  
.DvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_PTPRA_pd Subfamily PTPRA 253-407 3.2e-32 106.7 In-house 23-162 (330) alignment 
Range on Protein: 253-407
Range on HMM: 23-162/330.0
INPRESMEKTGISEEFDRLSQEALPAEQYLSKREgrrpVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfeNSQRTKNvtfacekSFIATQG
|. | . .   . |||. |    . |   |...|     | ||||. ||.|.|..||||. .  .. |||||||..   .  . |.       .|||.||
irirsaddnklfreefnalPagpiqatlelaske....enkeknrvvnilPydfsrvilsvkeGveesdyinasfi...dGykekd.......kfiaaqG

CLETTISDFWSMVWQENSRVIVMPTMENERK-EKCARYWPAEVNKpeVHGDISLTC
 .| |. ||| |.|. .|  ||| |  .||| ||||.||| |      .|.| .. 
PkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv..tyGnirvev
0051082 (Phosphotyrosine protein) phosphatases II 319-576 4.2e-32 106.2 In-house 2-148 (151) alignment 
Range on Protein: 319-576
Range on HMM: 2-148/151.0
GSDYINASYVRFEnsqrtknvtfaceksFIATQGCLEttisDFWSMVWQENSRVIVMPTMENERKeKCARYWPAEVnkpevhgdisltctierkvqravs
 |||||.|||                  .....| |.    ||. ...... ..||. . | ||. .|..|.|..                         
lsdyinfsyvtgg...............lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg........................

devkaeleqektnriakglvpeaelngdgisyilrtlvmkkgkdtREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnaqpiaasLPQGPIVVHC
                                             .|......| |||.|.||.. |||.||| ...              ..||..|||
.............................................ievlhipildwpdpglplsfdavleflellld.............kkngpvlvHC

SAGIGRTGTVLVLDALLNQvkkvgllcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKA
|||.|||||. .|. .| .         ..... ....| .| |.||..||..|...|
saGkgRTGtlvalylmllg.........vsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_PTPRB_pd Subfamily PTPRB 449-584 6.6e-32 105.7 In-house 164-288 (293) alignment 
Range on Protein: 449-584
Range on HMM: 164-288/293.0
SYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfnaqpIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMD
 ...|.| ..|.|..|..||.....||||| | .. ..|.|.. |...        |  .  ..|||||||||.||||| . || ||.....  .   .|
dwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvrea........iektaskrPivvhCsaGvGRtGtfialdrllqaieeedy...vd

VYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNN
.. .|  .|. |  |||||.|| |.....  .|...
ifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 261-433 7.4e-32 105.6 In-house 20-178 (297) alignment 
Range on Protein: 261-433
Range on HMM: 20-178/297.0
KTGISEEFDRLSQEALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSqrtknvtfacekSFIATQGCLETTISD
... . .. .     ||. .  ..   .. || ||.|||||.|.|  ||.|  . . | |||.|||.|.  .              .|.||   ..|. |
qknrhtdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh............rlittqmPmkatvad

FWSMVWQENSRVIVMPTMENERKEKCARYWPAEVNKPevHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRI
|| ||..|.  .||| . .|||..||||||. .  ..   ||.|.. .   . .  .  |.. . .. |..|.
fWamvldeqvstivmlnddnerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrv
PTPc_DSPc_SM00012 466-578 1.8e-31 103.8 In-house 2-104 (105) alignment 
Range on Protein: 466-578
Range on HMM: 2-104/105.0
IRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllCPMDVYKMVKYVRTYRSGLVQ
.....|..|||||.| .. ..|..|..|....   .         ..|.|||||||.|||||. .|| ||.|..|      .|....||..|..|.|.||
vkhyhytgwpdhgvPeesdsilellravkknknkses........skpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvq

TEQQYQFLYKALA
||.||.|||.||.
teeqylflyrall
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 449-586 1.9e-31 104.3 In-house 158-285 (318) alignment 
Range on Protein: 449-586
Range on HMM: 158-285/318.0
SYILRTLVMKK--GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyFNAQPiaaslPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcp
.|.||.. ...   ...|..|| .| .|||.| | ..  .|... .|..     ....      .||||||||||.||||. ...|.||...|. .|   
dyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvsk....aqqks.....gagpivvhCsaGvGrtGvfiavdillerikaeal...

MDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNP
.||...|| .|. |  .||||.||.|.|..|  .|.  ..
vDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 264-397 4.9e-31 102.4 In-house 20-139 (515) alignment 
Range on Protein: 264-397
Range on HMM: 20-139/515.0
ISEEFDRlsqeaLPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWS
.||||       ||  .   .   .  .| .|||||||.|.| .||.|    . | |||.||||..          .| ..|..||.|| ......|||.
fseefhd.....lpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip..........sfdndkayiasqgPnkasvddfWr

MVWQENSRVIVMPTMEN-ERKEKCARYWPAEVNKP
.|.|||   |.| |  . . | ||..|||    . 
lvlqenvttiamvtklkegdkikcgkyWPdkpgds
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 292-583 5.4e-31 102.4 In-house 48-289 (305) alignment 
Range on Protein: 292-583
Range on HMM: 48-289/305.0
NAEKNRYKNIVPFDHTRVILtdRPNTPgSDYINASYVrfensqrtknVTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTME-NERKEKCARYW
.|.|||||..  .|. || |  ..  |  .|| | ||           | .  | || ||  || | .||| | .|..   | |     .   .||. |.
eagknrykdvgcldnnrvkl..egpwp.heyihanyv..........stptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyf

PAEVnKPEVHGDisltcTIERKVQRAVSDEVKAELEQEktnriAKGLVPEAELngdgisyilrtLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFL
...  |.... .       ..|..  .   |. .....     ||  | |..|           ..   |...| . .  .  ||| | |    |.|..|
askd.kdvlefe.....ekgqkisvkfessvtlkfrkd.....akakvtetvl...........viegpgekarkvthyhwidwpdrgvpaadlailell

EdvdreydyfNAQPIaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKN
|         .|.|      .|||||||||||||||.|..|. .|.|.     .   |  |... .|  |   .||..|| |... .  |...
e.........karps.....kgpivvhcsagigrtgsvvmleyildqllagqii..edtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 251-434 1.4e-30 101.4 In-house 4-173 (281) alignment 
Range on Protein: 251-434
Range on HMM: 4-173/281.0
RPINPRESMEKTGISEEFDRLSQEALPAEQYlskrEGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIAT
. .. ... ...|  ||.. |..  .           ... | .||||.||| .|.||| .|.  ..  .|||||..|           ..  || .|||
khlkqlsqndnaGfieeyeklaaigvdntat....askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp..........gykgekeyiat

QGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPaEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIA
|| . ... .|| |||... ..||| | | |  | || |||| . |.    ||. .. | |.. .. .. ..| | |. .| ...
qgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkleresgetreve
subfamily_PTPN13_pd Subfamily PTPN13 257-406 1.4e-30 101.5 In-house 6-140 (273) alignment 
Range on Protein: 257-406
Range on HMM: 6-140/273.0
ESMEKTGISEEFDRLSQeALPAEQylsKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNtpgsdYINASYVRFENsqrTKNvTFacekSFIATQGCLET
. ...   .|||. | .   | ..    ..|..  | .||||.|..|.|.|||.| |  .     |||||... .     |. ..    ..||.|| | .
kkldqqqPaeefkelre.lkpldt...cevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpv...gkd.ey....eyiacqGPlPe

TISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNKPEVHGD-ISLT
|..||| |||. ...||.| |.| |. | || |||| . ||. .  . . ..
tvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrleve
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 294-582 1.4e-30 100.9 In-house 50-345 (349) alignment 
Range on Protein: 294-582
Range on HMM: 50-345/349.0
EKNRYKNIVPFDHTRVILTDRPNTPGSDYINAS------YVRFENSQRTKNVTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKC
 |||||.|.|..|.||.|   .... .     |         . |.   |   .. || .||||  | .|. ||. ..  .. ....  . ..|   |||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

ARYWpAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELEQEKTNRIAKGlvPEAELNGDGISYILrtlvmkKGKDTREIRQLQYLTWPDHGCPLHPYAV
 .||  | .  ...  .  .      || ...   . . .... . . |    . . ..|  .  |      . ..  |. |||.  |.| .  | | ..
diyw.qelsysnitvklqnsslyianvqGnslrvstvkdtdndndnnkkn..Cdlpddddddaill......avekPyellqlqvknwldlslllnPisi

LNFLEDVDREYDYFNAQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLN-------QVKKVGLLCP-MD-VYKMVKYVRTYRSGLVQTEQQYQFLYKAL
|. ||  .   |  .|.    .    ...|||||| ||||..  || ||.       .  |. |     | .. .|  .| .|  .||  .|. ..|.||
lqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal

AFYLK
 .|..
Lkyfa
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 449-579 2.1e-30 100.8 In-house 160-277 (288) alignment 
Range on Protein: 449-579
Range on HMM: 160-277/288.0
SYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKvglLCPMD
...||.| ..| |. .|| |.|||.||||| |     .|..|. |.   .            .|||.||||||.||||| ..||||...|..      .|
dfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad..........tgpiivhCsaGvGrtgtFialdalidavee...edyiD

VYKMVKYVRTYRSGLVQTEQQYQFLYKALAF
|  .|. .|  |  ||||..||.|.|..|. 
vagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPRA_pd Subfamily PTPRA 457-584 3.5e-30 100.0 In-house 184-299 (330) alignment 
Range on Protein: 457-584
Range on HMM: 184-299/330.0
MKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnAQPIAAslpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcpmDVYKMVKYV
... |..| .||. . .||| | | .|  .|..|. | .       ..  |    ||||||||||.||||| .||||.|..||  ...   ||...|| .
atrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk......lnqqsa....gpivvhcsaGvGrtGtfivldavlervkaerkv...dvfefvkrl

RTYRSGLVQTEQQYQFLYKALA-FYLKNN
|. |. .|||..||.|.||.|  .||  .
rlqrpqmvqtdeqyefiykvlleyylygd
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 274-426 3.7e-30 100.2 In-house 30-168 (325) alignment 
Range on Protein: 274-426
Range on HMM: 30-168/325.0
EALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMV--WQenSR
. ||...  .|.   .| | .|||.||.|..|..||.|  . . | ||||||||.|          ..   . |.|.|  | .|| |.| .|  |.  . 
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylr..........ddkkkdvflaaqaPltatindlWrlvldWr..cs

VIVMPTMENERKEKCARYWPAEVNKPEVHGDISLTCtieRKVQrAVSDEVKAELE
|.|.  . .. |..|| ||| |. |    | . .     | ..  .|| |.  |.
vvvvlneldlgkdrcavywpkemgksktfGglevkl...rtie.eisdyvhrvld
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 287-412 4.3e-30 99.7 In-house 4-117 (250) alignment 
Range on Protein: 287-412
Range on HMM: 4-117/250.0
GRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERKEKC
...| | ||||| .|...|..||.|        |||||||..           ..  .|.|||||| |..|| ||| ||..|.| .||| |  .| ....
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflh..........gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekty

ARYWPAEvnKPEVHGDISLTCTIERK
 .|||.|  |.| .||. ..   . .
hqywPve..kaekyGdvtvsllskee
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 449-583 6.2e-30 99.3 In-house 154-278 (281) alignment 
Range on Protein: 449-583
Range on HMM: 154-278/281.0
SYILRTLVM-KKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAqpiaaslpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKVglLCPM
.|| |.. . ... .|||..||.|..||||| |  . ..|.| ..| .  .  .           |.|.|||||.||||| . || |...|..   | ..
tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk.........aplvihCsaGvGrtGtyialDrlvkaveae..leel

DVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKN
||  .|. .|  |  .|||  ||.|.|||.  .|..
dvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 266-581 1.3e-29 97.8 In-house 28-289 (305) alignment 
Range on Protein: 266-581
Range on HMM: 28-289/305.0
EEFDRLSQEALPA-EQYLSKREGRRPVNAEKNRYKNiVPFDHTRVILTDRPNtpGSDYINASYVrfensqrtkNVTFACEKSFIATQGCLETTISDFWSM
||| .|.. . |   | . . .    ..  ||||.. || .   ... |.|.   |||| | ||          . .  || ||..|| |. || .|| |
eefrglakytrpdmtqvafnanqsadiaitknryqd.vpcqdqsavkldkps..psdyihanyv.........gcpmipekrficaqgpldqtidefwwm

VWQENSRVIVMPTMEN-ERKEKCARYWPAEV-NKPEVHGdislTCTIErkvqrAVSDEVKaeLEqeKtnriakglvpEAELNgdgisyILRTLVMKKGKD
| |..   |||        | |||.||||   .| |...     . .|      ||      .|  .          .||..      |    .   |..
viqnkveqivmlcktvelgklkcaqywpaaqgeklelks....givve.....nvsgskp..me..r..........daeiq......itllnltysgdq

TREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDreydyfnaqpiaASlpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDvyKMVKYVRTYRSG
.  .|.||.  ||| | |    . |..|  .              |  . |||||||||||||||.. .. .|... .     ||   ..|| .|  |. 
kmsvrhlqwtewpdrgvppckltslellsair............gs..kvpivvhcsagigrtgtivaieyilekiaenkpcppmp..elvkalrdqraf

LVQTEQQYQFLYKALAFYL
 .|.. || |... .  |.
siqndvqylfihrvmlnyf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 450-584 4.5e-29 96.4 In-house 121-245 (250) alignment 
Range on Protein: 450-584
Range on HMM: 121-245/250.0
YILRTLVMKKGKDTRE--IRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAqpiaaslpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpM
|. |.|.. | | . |  .|||....||| | | .  |||..|..| .. .. ..         .|..|.||||.||.|. ...||.|...||      .
ytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagn.........aPvivqCsaGvgrsGafiaidavlerlkkekv...v

DVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNN
||.|..| .|. | . |....|| |.|...  .|.  
dvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 290-411 8.1e-29 96.0 In-house 23-129 (284) alignment 
Range on Protein: 290-411
Range on HMM: 23-129/284.0
PVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfeNSQRtKNvtfacekSFIATQGCLETTISDFWSMVWQENSRVIVMPTmenerKEKCARY
. | .|||. .|..||...| |       .|||||||..     || |.        .||||| |. |. ||| |.|. |.  ||. |     |.||..|
dqnkdknrighilafdknvvklerliGeefsdyinasfit..Gyqr.kd.......kyiatqGPldntladfWrmiweyncstivllt.....kdkcsqy

WPAEVNKPEVHGDISLTCTIER
|| .... | .......   | 
wplkivikeerfkvkvdsvees
subfamily_PTPN9_pd Subfamily PTPN9 449-581 1e-28 95.3 In-house 156-290 (297) alignment 
Range on Protein: 449-581
Range on HMM: 156-290/297.0
SYILRTLVMK--KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNA---QPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGL
 |  |.|..|  | ...|..   |.|.|||.| |    ..|..|| | ..   .     .. .  . . |||||||||||||||   ||  |.....|| 
dykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgt

lcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL
   .|| . ||..|| |.  .||..||.| |.|.  | 
...vdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN13_pd Subfamily PTPN13 450-582 1.2e-27 91.9 In-house 150-270 (273) alignment 
Range on Protein: 450-582
Range on HMM: 150-270/273.0
YILRTLVM--KKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnaqpIAAslPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPM
. .|.| .  .. ...||. .|.. .||||| | ..  .|.|.  | |         ..    .|||||||||||||.||....|..|. ...     ..
fvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrr.........lqt..dagPivvhcsaGiGrsGtlitidvvlglierdk...ef

DVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
|| ..|. .|  | |.|||..|| | |||.   ||
dvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 261-406 1.7e-27 91.0 In-house 9-141 (287) alignment 
Range on Protein: 261-406
Range on HMM: 9-141/287.0
KTGISEEFDRLSQEAlpAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTpGSDYINASYVrfensqrtknVTFACEKSFIATQGCLETTISD
|  . .|.|.| ...      .  ..     ...|||| ...|.|.|||.|.  ..  ||||||| ||           ..  ...|||.|| . .|. |
kddvdkevdalkeds..esstatfkaaeelaavkknryadvlPiddtrvllsaegel.Gsdyinanyv..........asytddeafiaaqgPiaatvrd

FWSMVWQENSRVIVMPTMEN-ERKEKCARYWPAEvNKPEVHGDISLT
|| .|....| .... | |  | . || .|||   ..|   |  |..
fwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 450-582 1.7e-27 91.4 In-house 161-284 (305) alignment 
Range on Protein: 450-582
Range on HMM: 161-284/305.0
YILRTLVMKK---GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcp
|| | | . .    |..| . |.|  .||||| |  . ..|.....| ...   .         . |..||||||.||||. ...|  |...|| .    
yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk.........gvpllVhCsagvgRtGvfiavdialerlkkEev...

MDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
.||....| .|. | ..||| .||.||. ||. ...
vdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 257-426 2.2e-27 91.0 In-house 17-171 (305) alignment 
Range on Protein: 257-426
Range on HMM: 17-171/305.0
ESMEKTGISEEFDRLSQEalPAEQYLskreGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLET
......|. .... | .|  .    .    |.. .|..|||.|.|...|. |.||| ..... |||||||||           ..  .|..|..|| |..
rvysdkgleaqykslyee..eesidv....gkkeankaknrlkeitlldddriiltekeslddsdyinasyvd..........gykrkkkyivaqgPlkn

TISDFWSMVWQENSRVIVMPT-MENERKEKCARYWPAEVNKPEVHGDISLTCTIERKVQRAVSDEVKAELE
|..||| ....|  ..||| | . .. |.|| .||| ...... .|..|.. . |....  .  ..|.  |
tvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisie
subfamily_PTPN14_pd Subfamily PTPN14 260-396 3.4e-27 90.2 In-house 21-145 (300) alignment 
Range on Protein: 260-396
Range on HMM: 21-145/300.0
EKTGISEEFDRLSQEALPAEQYLskreGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTpGSDYINASYVRFENSQRtknvtfacEKSFIATQGCLETTIS
|.. .  |..|.... . |. .     .. |.||||||.|...|....|| |.   ..  ..||||| ..   . .        |.|.|..|| ||.|. 
eegkvfteyeripkkredallst....aklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggk........ersyivaqgPleltvq

DFWSMVWQENSRVIVMPTME-NERKEKCARYWPAEVNK
||| |||... ..||| | | .. |||. .|.| . .|
dfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 450-596 3.9e-27 89.5 In-house 158-292 (515) alignment 
Range on Protein: 450-596
Range on HMM: 158-292/515.0
YILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNaQpiaaslpqgPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDV
 | |.| . ||.|.| . | ..  |||.| | |  ..| .. .|  . . ..           |...|||||.|||| |. .|  . ..|.      .||
gikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.h.........pliihcsaGvGrtGvvisidsvvahakttrm...vdv

YKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK-NNNPYPVKSFIDGD
...|. .|  |  ||||..|| |.| |.  .|.  |   ||  | |  
fnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 288-396 4.7e-27 89.7 In-house 4-104 (239) alignment 
Range on Protein: 288-396
Range on HMM: 4-104/239.0
RRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENsqrtknvtfACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTM-ENERKEKC
.. ||  |||| ||| .||.||.|    | | ||||||||.|  .            |..||||||.|..  ||| |.|||   |||| |   . .|.||
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdyd.........gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkc

ARYWPAEVNK
 .|||   .|
hqywpdstsk
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 289-396 5.2e-27 89.5 In-house 4-103 (239) alignment 
Range on Protein: 289-396
Range on HMM: 4-103/239.0
RPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENsqrtknvtfACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTM-ENERKEKCA
. ||  |||| ||| .||.||.|    | | ||||||||.|  .            |..||||||.|..  ||| |.|||   |||| |   . .|.|| 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdyd.........gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkch

RYWPAEVNK
.|||   .|
qywpdstsk
subfamily_PTPN14_pd Subfamily PTPN14 450-584 5.6e-27 89.5 In-house 167-299 (300) alignment 
Range on Protein: 450-584
Range on HMM: 167-299/300.0
YILRTLVMK--KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQPIAaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPM
.| ..| .|    |. |..  |||  |||||.|  .   |..||.|.     .| .  .    . |..||||||.|||| ... | |.. ...      .
vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehne...ei

DVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNN
|. |... .|. |  ||||  ||.|.||.|  |||| 
dikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_PTPN3_pd Subfamily PTPN3 448-577 5e-26 86.2 In-house 153-271 (280) alignment 
Range on Protein: 448-577
Range on HMM: 153-271/280.0
ISYILRTLVMKKGK--DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYdyfnaqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLC
 ||.|| ||.|. .  . |.| ||||| ||||| | ..  .|.|.| | .            |  . |.|||||||||||| ...|.  |  . .   . 
ksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..........sgkeePvvvhCsaGigrtGvlilletalalieaaepvy

PMDVykmVKYVRTYRSGLVQTEQQYQFLYKAL
|.|.   |. .|  |. ||||..||.|. .|.
pldi...vrtmrdqramlvqtasqykfvCeai
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 450-595 5.7e-26 86.1 In-house 159-292 (315) alignment 
Range on Protein: 450-595
Range on HMM: 159-292/315.0
YILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREyDYFNaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDV
 . | ||..|....| . | |.  |||.| . .  ..|... .|  . .  .         . ...||||||.|||| |. .|  ..|.|.      .||
gvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkk.........efsllvhcsaGvGrtGvvisidevvaqikrtrs...vdv

YKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK-NNNPYPVKSFIDG
...|| .|. |  |||||..| |.| |.  .|.  |   .|  | | 
fnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdh
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 292-406 7.6e-26 85.8 In-house 3-106 (237) alignment 
Range on Protein: 292-406
Range on HMM: 3-106/237.0
NAEKNRYKNIVPFDHTRVILTDrpNTPGSDYINASYVRFENsqrtknvtfACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENE-RKEKCARYW
|  |||| ||| .||.||.|    .  |||||||.|..  .            |..||.|| ||..  ||| |||||.  |||| |   |  ..|| .||
nkiknrygnivaydhsrvvlkg..agsgsdyinatylkgfd.........gtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkyw

PaEVNKPEVHGDISLT
| . ..|. .| ....
p.stdqpaaygvltvs
subfamily_ptpA1_pd Subfamily ptpA1 264-395 8.2e-26 85.7 In-house 23-140 (418) alignment 
Range on Protein: 264-395
Range on HMM: 23-140/418.0
ISEEFDRLSQEALPAEQylskREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVrfensqrtknvTFACEKSFIATQGCLETTISDFWS
| |||  | .   |.|      || .  |. |||| ||.| .|||| |    .  ||||||| |.             |  | ||.||| |  ||.||| 
ikeefrlleesvgpset....segdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyi...........dgaypkqfictqgplpntiadfwr

MVWQENSRVIVMPTMENER-KEKCARYWPAEVN
|||..  |.||| . |.|  . || |||| .. 
mvwenrcriivmlsresencrikcdrywpeqig
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 450-577 1.9e-25 84.5 In-house 161-275 (315) alignment 
Range on Protein: 450-577
Range on HMM: 161-275/315.0
YILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyFNAQPIaaslpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDV
|  ||| .  |.. ||. ||.| .||| | | .  ...|.   | .    .. . .      |.||||||||.||||| . |||.|.|..   .   .||
ytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkq....hhtnsv......gaivvhcsaGvGrtGtfitldavldqaeaena...idv

YKMVKYVRTYRSGLVQTEQQYQFLYKAL
|.... ||  | ..||. .||||.|.||
ynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 264-402 4.6e-25 83.1 In-house 9-134 (297) alignment 
Range on Protein: 264-402
Range on HMM: 9-134/297.0
ISEEFDRLSQEALPAEQYLSKregrRPVNAEKNRYKNIVPFDHTRVILTDrpNTPGSDYINASYVRFENSQRtkNVtfacekSFIATQGCLETTISDFWS
. .| | | .|| . .   .|    |.    ||||..|. .| ||| |      ...||||| || | . .   ..       .| .|| |..|. ||| 
leaekdllldeargesfssak....rnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeea..dl......kyilaqGplsatvddfwt

MVWQENSRVIVMPT-MENERKEKCARYWPAEVNKPEVHGD
.|.... ||||| . .... ..||| |||  |..    ||
lvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 272-411 1.8e-24 81.3 In-house 29-156 (315) alignment 
Range on Protein: 272-411
Range on HMM: 29-156/315.0
SQEALPAEQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSR
  |..|  |    .  ..  | .|||| ||...|..|| |    | |.|||.||...            .. .. .||.|| . ... ||| .|..|.  
dyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfid..........Gynkkrryiaaqgpnvasvkdfwrlvfeedig

VIVMPTME-NERKEKCARYWPAEvnkPEVHGDISLTCTIER
 ||| |   .. |.|. .||| .     ..| |..|   | 
kivmltnlvegekrkaekywpdk...kviyGkitvtrksee
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 450-585 3.4e-24 80.5 In-house 161-288 (297) alignment 
Range on Protein: 450-585
Range on HMM: 161-288/297.0
YILRTLVMKKGK--DTREIRQLQYLTWPDHGCPL--HPYAVLNFLEDVDREYDYFNaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlc
.| |.|...|||   .| ..| |.. |||.  .   .  ..|.....|  ...  .         .||..|||.||.|||| .| .|  . ..|.     
fikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqna.........egPllvhclaGvGrtgvlltidsvvaeakreke..

pMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNN
 .|....|| .|  |  ||||..||.|.|.|.  .|  ..
.vdifglvkklrqerpylvqtkeqykfvyvavleallsed
0048076 (Phosphotyrosine protein) phosphatases II 442-580 5e-24 80.0 In-house 24-142 (145) alignment 
Range on Protein: 442-580
Range on HMM: 24-142/145.0
ELNGDGISYILRTlVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYfnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNqvkkv
.|   || ..|.   . .   .|.. |..|| |||||.|  .  .|.||| ... ..             ||..||||||.|||||. ... .|      
llkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealke...........ggpvlVHCsaGvgRtgtlvaaylmll.....

gllCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFY
   . ..... ...||..|.| |....|..|||...  .
...lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_PTPRN_pd Subfamily PTPRN 282-394 7.2e-24 79.0 In-house 46-150 (297) alignment 
Range on Protein: 282-394
Range on HMM: 46-150/297.0
LSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfENSQRtknvtfacEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENE
 .|  .... |..|||.|...|.||.|| |... ..  ||||||| .  ..  |        . ..||||| | .|..||| |||.. . |||. |  .|
stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail.dhdpr........apayiatqgplastvadfwqmvweqGvvvivnltrlee

-RKEKCARYWPAEV
   ..|.|||| | 
egvkqckrywpdeG
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 451-585 1.1e-23 78.5 In-house 153-281 (287) alignment 
Range on Protein: 451-585
Range on HMM: 153-281/287.0
ILRTL--VMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydYFNAQPIAASlpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllcPMD
  |.|  .  .....| ..||..|.|||.. .    ... |  || .   . ...  |.    ||.|||...||||.|..| . .|... ...|    .|
gvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkq...hielardase..vGPlvvhddvGiGrsGillatlvlvsrledlG...rvd

VYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNN
| ..| ..| || .|||.  |...||.||. | | | 
vaavvirlreyraalvqavvqlrllyealvtyyktnp
subfamily_PTPN23_pd Subfamily PTPN23 455-583 2.9e-23 77.1 In-house 162-282 (288) alignment 
Range on Protein: 455-583
Range on HMM: 162-282/288.0
LVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQPIAaslpqgPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCpmDVYKMVK
| ... . ..... ||. .||..| |  |  .|.||. |.  |.  . .  .      |.|||||||.||||.. .. | .....|   |   |. ..|.
letldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt......PlvvhCsaGvgRtgvfalvyaavrelekgngll..diiqvvs

YVRTYRSGLVQTEQQYQFLYKALAFYLKN
 .|. |   ||...|..|.|.|   . ..
rlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 450-592 3.1e-23 77.4 In-house 162-300 (325) alignment 
Range on Protein: 450-592
Range on HMM: 162-300/325.0
YILRTLVMKKG--KDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAQpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPM
|. | | .|.    .|| ..|.|. .|.| | . .| .....|. |.   .  .|.    .   .||.||||||.||||. . | ..|..| .      .
yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan....tkastpilvhcsaGvGrtGvfislysalakviee...srv

DVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL-KNNNPYPVKSF
|....|| .|  |  .|.|  || ..|.||. ..   |   || ||
difgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 450-578 3.6e-23 77.5 In-house 132-252 (284) alignment 
Range on Protein: 450-578
Range on HMM: 132-252/284.0
YILRTLVMKK---GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYFNAqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcp
|..| . . .    || |.|||  .| |||.| | .|  .. ... |    .  |         . .||||||||.||||. .|||.||...|.      
yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenh........ranivvhcsagvgrtgvyivldvlldrmkeekq...

MDVYKMVKYVRTYRSGLVQTEQQYQFLYKALA
.|||..|. .|  |. |||   ||.|.| || 
vdvynfvrdlrqqrntlvqdlvqykfiysall
0048179 (Phosphotyrosine protein) phosphatases II 462-575 1.2e-22 75.6 In-house 45-139 (144) alignment 
Range on Protein: 462-575
Range on HMM: 45-139/144.0
DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfnaqpIAaslPQGPIVVHCSAGIGRTGTVLVLDALLnqvkkvglLCPMDVYKMVKYVRTYRS
 .||. |...| |||||.| ..  .|.||| ...         ..   . ||..||||||.|||||. ... ..        .. ..... ...||..|.
leregiqylhlpwpDhgvpdllellleflefieea........le...eggpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrp

GLVQTEQQYQFLYK
| |....|..||..
gavpnpgqlrfLle
subfamily_CG42327_pd Subfamily CG42327 264-408 1.7e-22 74.5 In-house 7-138 (319) alignment 
Range on Protein: 264-408
Range on HMM: 7-138/319.0
ISEEFDRLSqealpaeQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSqrtknvtfaCEKSFIATQGCLETTISDFWS
. |||. |        | ... .   .   .|.|. |.||. .|||.|   .. . . |..|||||  ..         .. |.||.|  || . |||| 
vaeefrdlP.......qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydd.........apnsyiaaqvsledsssdfwr

MVWQENSRVIVMPTMENERK-EKCARYWPAEVNKP--EVHGDISLTCT
.||. .|||||  |   |   ..||.|.|..   .  ...||| .|  
tvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 291-423 3e-22 73.9 In-house 46-163 (287) alignment 
Range on Protein: 291-423
Range on HMM: 46-163/287.0
VNAEKNRYKNIVPFDHTRVILTDRPNtpgsDYINASYVrfeNsqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKCARY
 | .|||...|.. |  ||.| .. .    |||||...   .       ..  .| ||.... .  |. .|| .....|  .||| . |.|  .|.| .|
qnkdknRltqilvpdnyrvllkgehp....dyinavfi...d.......gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqy

WPAEVNkpEVHGDISLTCTIERKVQRAVSDEVKA
|| | .   | |. ... . | . .  .  ... 
Wpeeks..vvlGeyniellneevnagyierklev
subfamily_PTPRN_pd Subfamily PTPRN 450-578 2.3e-21 70.8 In-house 171-289 (297) alignment 
Range on Protein: 450-578
Range on HMM: 171-289/297.0
YILRTLVMK--KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDYfnaQpiaaSlpqGPIVVHCSAGIGRTGTVLVLDALLNQVKKvGlLCPM
|..|.. .|  . ..|| . |. .|.||..|.|  . ..|.|   |.. |     .    |    |||||||.| ||||. ...| .||...| | .  .
ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG...r....s...cpivvhcsdGaGrtGvyilidlvlnrllk.G.vkei

DVYKMVKYVRTYRSGLVQTEQQYQFLYKALA
|.   ....|  |.|||.|..|..| ..|.|
diaatlehlrdqrpglvktkdqfefaltava
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 449-576 5.7e-21 69.8 In-house 119-235 (239) alignment 
Range on Protein: 449-576
Range on HMM: 119-235/239.0
SYILRTLVMKKGKDTRE--IRQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfnaqpiaaSLPQ-GPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllc
 ||.||.|| .  .| |  . | ..  |||.| | .  ||| .   . ..           |||   | |.|||||.||||..||.||.| | ||     
dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...........slpgarpwvihcsagvgrtgaflvidamlrqakkqk...

PMDVYKMVKYVRTYRSGLVQTEQQYQFLYKA
 .|... || .|  |  .||| .|| |.. |
tvdifnyvkairedrphmvqtseqyvfihla
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 449-576 5.8e-21 69.7 In-house 120-236 (239) alignment 
Range on Protein: 449-576
Range on HMM: 120-236/239.0
SYILRTLVMKKGKDTRE--IRQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfnaqpiaaSLPQ-GPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllc
 ||.||.|| .  .| |  . | ..  |||.| | .  ||| .   . ..           |||   | |.|||||.||||..||.||.| | ||     
dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkd...........slpgarpwvihcsagvgrtgaflvidamlrqakkqk...

PMDVYKMVKYVRTYRSGLVQTEQQYQFLYKA
 .|... || .|  |  .||| .|| |.. |
tvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 259-414 1.1e-20 68.5 In-house 24-164 (290) alignment 
Range on Protein: 259-414
Range on HMM: 24-164/290.0
MEKTGISEEFDRLSQEALPAeQYLSKREGRRPVNAEKNRYKNIVPFDHTRVILTDRpnTPGsDYINASYVRfensqrtknvtfACEKSFIATQGCLETTI
..  ... |.    .  ||. ||| ..   .  . .|||||..|  | ||||| |    .| ||. | ||.              .  || ||| |. |.
knvdelakeyleklkpylpv.qylerkifdkntefkknrykdvvcndktrvilkdG..ydG.dyvhanyvk............GlkamfiltqGalkdtv

SDFWSMVWQENSRVIVMP--TMENeRKEKCARYWPAEVNKPEVHGDISLTCTIERKVQ
 |.| || ||.  .|||    .|.  | ||..|.| .  .    |.|...|. | . .
idiwrmvlqekvaaivmlcelied.GkakceqyypekeGevltfGeitvlcseeddkd
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 449-581 7.8e-20 66.1 In-house 161-277 (307) alignment 
Range on Protein: 449-581
Range on HMM: 161-277/307.0
SYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVkKVGLLCpMD
   . || .. ....| |..||.  |||.|.|    . .|.|| |  .              . |.|||||||.||.||.. .  . ...   |  | .|
linvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd..............tnpvvvhcsaGvGrsGtivaislvqdkm.iaGinc.kd

VYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL
. |.|. .|. |   .||| || .|.. |  |.
mkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 455-577 8.6e-20 65.8 In-house 155-291 (297) alignment 
Range on Protein: 455-577
Range on HMM: 155-291/297.0
LVMKKGKDTREIRQLQYLTWPDHGCP-----LHPY---------AVLNFLEDVD--REYDYFNAQPIAASLPQ-GPIVVHCSAGIGRTGTVLVLDALLNQ
| .   ...| .|  |.|.||||| |     |  .         ||  .|  |.      ... . . |  |.  ...||||||.||.| |.  |..|..
lqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilak

VKKVGLlcPmDVYKMVKYVRTYRSGLVQTEQQYQFLYKAL
..|  .  | ||  .....|  |. |||| .|...||.| 
lrkkri..p.dvaailsilreqrarlvqtleqfellydav
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 292-582 8.8e-20 65.9 In-house 43-272 (288) alignment 
Range on Protein: 292-582
Range on HMM: 43-272/288.0
NAEKNRYKNIVPFDHTRVILTDRPNTpgsdYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPT-MENERKEKCARYW
|. ..||.|.   | ||| |.| |.     ||.|  |           .   .. .| .|  |..||  .| |. ... . ||| . . .  ||| | |.
nptrdryenlprcditrvklsddpdf....yiaanvvs..........sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf

PAEVNKPEVHGDIsltctierkvqravsdevkaeleqektnriakglVPEAELNGDGISYILRTLVMKKG--KDTRE-IRQLQYLTWPDHGCPLHPYAVL
| .. .    | .                                        . ..|  ...  ...     ...  ...| .| |.|.| |    . |
PsklGekarigrl..................................ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylspl

NFLEDVdreydyfnaqpiaASLpQGPIVVHCSAGIGRTGTVLVLDALLnqvKKVGLLCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
..|| .              || | |||||.|||.|||||. .    |   . . |   . . ....  |  |   .|||.|| .... .  .| 
rllevl.............ksl.qkPivvhssaGvGrtgtlililial...eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 450-576 1.6e-19 65.1 In-house 116-234 (237) alignment 
Range on Protein: 450-576
Range on HMM: 116-234/237.0
YILRTLVMKK---GKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVdreydyFNAQPIAASlpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcp
| .|.|.. |    |. | | | |. .|||.| | .  |.| |  ..       |  |  .    || ..|||||.|||| .||.||.| | |.  .   
ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkni......inrsphvse..sgpwiihcsagvgrtgiflvidamlrqakekkv...

MDVYKMVKYVRTYRSGLVQTEQQYQFLYKA
.|.|. |. .   |  ..||..|| |....
vdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 459-577 2e-19 64.4 In-house 169-275 (439) alignment 
Range on Protein: 459-577
Range on HMM: 169-275/439.0
KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREYDyfnaqpiaaSLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYKMVKYVRT
...  | . |..|..|||.  | .   ||.||  ..   |         .   ||.|||||||.|||||.. ||  |.|.|       .|.  .||..| 
ttekertvlqfhyiawpdknvpaqashvldflrainsand.........keeygpvvvhcsagvGrtGtiialdialeqlkle...nkvdikgivkvlrk

YRSGLVQTEQQYQFLYKAL
 |  .||.  || |.|.|.
qrkqmvqalcqyvfiynav
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 289-394 2.8e-19 63.8 In-house 34-131 (281) alignment 
Range on Protein: 289-394
Range on HMM: 34-131/281.0
RPVNAEKNRYKNIVPFDHTRVILTD-RPNTPGSDYINASYVRfensqrtknVTFaCEKSFIATQGCLETTISDFWSMVWQENSRVIVMPT-MENERKEKC
.||| .|||| ||  .| .|| |    ||   .||| | |.|           |  .. .| |||  . | .||| |.||||.  |||   . .  .|||
qpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir.........spf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekc

ARYWPAEV
| |.| . 
aeyfprna
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 450-585 1.1e-18 62.3 In-house 156-282 (287) alignment 
Range on Protein: 450-585
Range on HMM: 156-282/287.0
YILRTLVMK---KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREyDYfnaQPiaaslPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcp
|| |.| .|   | .|.....| |. .|...|   .| ..|  .|.  .. ..   ..      ...||||||...||... .  .  .|..|. |    
yierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemykt.qr...kr.....gntsivvhCsdtvGrsamfcaaattinkckteGv...

MDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNN
.||....|  |  . | ||| .||.|.....  ||.  .
iDvfqvlksqriqkpgsvqtveqykfindivleyldsfe
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 291-412 1.2e-18 62.2 In-house 40-150 (307) alignment 
Range on Protein: 291-412
Range on HMM: 40-150/307.0
VNAEKNRYKNIVPFDHTRVILTDrpNTPGSDYINASYVRFEnsqrTKnvtfacEKSFIATQGCLETTISDFWSMVWQENSRVIVMPT-MENERKEKCARY
 |..||||...   |..|....   .   |||| | |.       .|       | ||..|| ||.|. .||.|. ||.   ..|   . .  | || .|
antdknryqdvkcqdkgrivvkf..dglasdyihanylgia....ik......pkkficaqgplentqysfwamaiqekvesvimlckvielakikceqy

WPAEVNKPEVHGDISLTCTIERK
||.|  .  |.|. . | ...  
wpleegqklvfgeapntisvanl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 292-407 2e-18 61.1 In-house 48-147 (439) alignment 
Range on Protein: 292-407
Range on HMM: 48-147/439.0
NAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrtknvTFACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPT--MENERkekcarY
.  |||||....||||||.| . |  | | |||| |..           .  .| .|||||  . |  ||| .|.....  ||| |  .|  .      |
dqtknrykdvgafdhtrvtlqeipgvphshyinanyik..........Gyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk......y

WPAEVNkpEVHGDISLTC
||.. .   ..|||.. .
wpsdae..vcygdiavrv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 459-577 1.7e-16 54.6 In-house 84-190 (440) alignment 
Range on Protein: 459-577
Range on HMM: 84-190/440.0
KGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnAQPIAAslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRT
.| ..| ..| .|  |||.| |     ||....||.       .|  |.   .||..|||||| |||| ....|..| ..|.      .|.. ... .| 
ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvne......sqekag...ngpllvhcsagagrtgviiavdsilreakrsdq...idifsfinsmrn

YRSGLVQTEQQYQFLYKAL
 |  .||| .|| |...|.
nrpqmvqtpeqyafvheav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 291-412 2.3e-16 54.6 In-house 32-137 (267) alignment 
Range on Protein: 291-412
Range on HMM: 32-137/267.0
VNAEKNRYKNIVPFDHTRVILTDRPNTpgsdYINASYVrfeNSQRTKNvtfacekSFIATQGCLETTISDFWSMVWQENSRVIVMPTMenERKEKCARYW
 |.|.||. . .|.|.||||| .. .     |||||||   .. .|||        ||.||. |. ||.||. .. ...  |||. |.    ...  ..|
knqernrlddnlpyddtrvilrtkeee....yinasyv...egyktkn.......afivtqdplkntitdfltvihdqkvpvivlltk..vftdnirlfw

PAEVNKPEVHGDISLTCTIERK
| .. . . . |...  ..|..
PPkmgqakkyqdltvehsleke
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 292-406 5.3e-16 53.1 In-house 52-155 (310) alignment 
Range on Protein: 292-406
Range on HMM: 52-155/310.0
NAEKNRYKNIVPFDHTRVILTDRpNTPGSDYINASYVRFENsQRtknvtfaceKSFIATQGCLETTISDFWSMVWQENSRVIVMP-TMENERKEKCARYW
.  |||| ..|  | .|| |.   ..   ||| | ||. .   |         ..|| .|| |. || ||| |..|| .  |..   . .| . ||  ||
ymhknrysdvvcldtsrvklkid.ksryedyihanyvktny.lr.........stficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgyw

PAeVNKPEVHGDISLT
|. .   | .| | .|
ps.lgvtetygcirvt
subfamily_CG42327_pd Subfamily CG42327 511-582 1.3e-15 51.9 In-house 247-316 (319) alignment 
Range on Protein: 511-582
Range on HMM: 247-316/319.0
QGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGllCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
|||.||||| |.||||.|.  |  ......      .|. ..| .||  |.  |.| .||.|.|| |  | |
qGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 512-580 2.5e-15 51.2 In-house 193-258 (267) alignment 
Range on Protein: 512-580
Range on HMM: 193-258/267.0
GPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcpmDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFY
 |.||.||.|.||.|| ||.|. |...|. | .   |...... .|  | |||.| ..| .... || |
rPlvvacsdGvGrsGtflvidsqleraktegvs...difdflrkirsqriglvdtkeryiyihellaey
SH2 SH2 domain 134-211 2.8e-15 46.7 Pfam-A 1-77 (77) alignment 
Range on Protein: 134-211
Range on HMM: 1-77/77.0
WWHGNLPASSANKLLQT-EKNGTYLLRASQHIPGALVISAKTEGQVVHLTIYQDPSTGRFNIDGDRtkFQSAWLLIDSY
| ||..  . |..||.. .|.||.|.| |.. || ...| ...|.| | .| .. . . .  ....  |.| . |.. |
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenek..fsslqeLvehY
subfamily_egg_pd Subfamily egg 292-407 1.2e-14 48.8 In-house 40-146 (307) alignment 
Range on Protein: 292-407
Range on HMM: 40-146/307.0
NAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRfensqrTKNVtFaceKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERkEKCARYWP
| || | | .   | .|| |  |      |.| | .|.       | . .     || .|  |  |  ||| ||.||. . ||| |   |  |.|  |||
nlekarskrvhckdssrvklelrrGqylddfihanrvk......Gkpl.l...nefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywp

AEVNKPEVH--GDISLTC
   ... |   | . ...
kaesdslvtvpGslrien
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 453-584 3.1e-14 47.3 In-house 170-286 (290) alignment 
Range on Protein: 453-584
Range on HMM: 170-286/290.0
RTLV---MKKGKDtREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnAqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDV
.||    ...||.   .. |.  .|||.  .|   |.|  |  . .      |         ||.|||||||||||||   ... |. . .      .|.
ktlsvrdkdsGke.hklkhlkikswpdksvalstlallrtlrilrk......a........sGpvvvhcsaGiGrtGtfvaievglqilldGke...ldl

YKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNN
 ..|. .|  | . || . ||  | ..|  . |..
ldlvralrnsrlnsvqvdiqylalveilldlGkdf
SH2 SH2 domain 13-92 6.7e-14 42.3 Pfam-A 4-77 (77) alignment 
Range on Protein: 13-92
Range on HMM: 4-77/77.0
YRVNGEKAEELLKEYGEDGDFLLRYSESNPQNFSISVRVAEdKILHIKVTKYESDMLSIFEDERttpnqFGSITELAEFY
  ...|.||.||.| ..||.||.| |||.| ....||.  . |. |... . |.  . |.|.|.     | |..|| |.|
gkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg.kvkhyriqslengkyyitenek.....fsslqeLvehY
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 291-408 6.7e-14 46.5 In-house 34-139 (285) alignment 
Range on Protein: 291-408
Range on HMM: 34-139/285.0
VNAEKNRYKNIVPFDHTRVILTDRpntpGSDYINASYVRFENSQRTknvtfacekSFIATQGCLETTISDFWSMVWQENS-RVIVMPTMENERKEKCARY
 | . ||| ..   . |||.| ..      ||| ||..|.   ...         ..|.||| |  |.|||| |..||.   |... |. .   |||| |
anpdlnryadvrcieetrvvlknh....drdyihaswmrmpgkdqs.........tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPAEVNKPEVHGDISLTCT
.| .. .    |   .| |
ypeklgevvkfgkyeitlt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 295-582 9.8e-14 45.8 In-house 46-277 (312) alignment 
Range on Protein: 295-582
Range on HMM: 46-277/312.0
KNRYKNIVPFDHTRVILTDRPNTpgsdYINASYVRFensqRTKNvtfaceKSFIATQGCLETTISDFWSMVWQENSRVIVM-PTMENERKEKCARYWPae
 ||| ||  .|  |  |.   |     || | .|.      ||       . |..||| || |.. || ..    |  |..  .. ..  ||||.|    
lnrypniqcwdrgrftlagdenf....yihanfvki....ctkp......erfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis..

vnkpEVHGDISLtctiErkvQRAVSDEVKAELEQEKTNRiakglvpeaelngDGISYILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDV
    .. | . |    |   .  |  |  .|.|     .             | |.. .  .|.|   .   . . |. .||||| |    . | .|  |
....divgfvdl....e...dhrvyteycteieiggksk.............dkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsav

DREydyfnaqpiaaslpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcpmDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
 ..              . |.. |||||.|||||. ......  ...       .| ..   .|  |.  |..  || .  ...  .| 
kkd..............kkpviahcsagvgrtgtlaliesmiaalrhprkq...nvkdsfvllrkdrarsvrvfpqyvyalrcvlefly
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 345-574 1.9e-13 44.5 In-house 74-281 (302) alignment 
Range on Protein: 345-574
Range on HMM: 74-281/302.0
KSFIATQGCLETTISDfwsmvwQENSRVIVMPtmeneRKEKCARYWpAEVNKPEVHGDISLTCT---IERKVQRAVSDEVKAELEQEKTNRIAKGLVPEA
 ..| .|| .. |         .. |.. ..|     .|. . ..| | ... .|   . |.      |.|.    ||.|. ||.  .    .. .  . 
ikwimaqGpmdGtekk......ekvskkpivp.....kkstlekhw.alieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdl

ELNGDGISYILRTLVMKKG----KDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDreydYFNAQpiaaslpqgpIVVHCSAGIGRTGTVLVLDALLNQ
|   |  |. | |. .|      |  . .  |.. .||||| | ..|. |. |   .     .  .          ..||||||.|||||.. .   .. 
eeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfce....sykkn..........vlvhcsaGvGrtGtlvaikyGiql

VKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLY
 .|       |. ..|. ||. | | ||.|||  .| 
cskkkv...tdllsivlpvrqcryGavqdeqqliyll
subfamily_ptpA1_pd Subfamily ptpA1 451-530 7.7e-12 39.6 In-house 173-248 (418) alignment 
Range on Protein: 451-530
Range on HMM: 173-248/418.0
ILRTLVMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDREydyfNAQPIAASLPQGPIVVHCSAGIGRTGTVLV
| | . .    .||.| | ||  ||||  | |   . ..|  .       . | | .|  . ||.||||||.|||||.  
itrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr....qnqiipssdrnvpiivhcsagvgrtgtfct
0038934 (Phosphotyrosine protein) phosphatases II 471-583 2e-11 39.4 In-house 84-179 (194) alignment 
Range on Protein: 471-583
Range on HMM: 84-179/194.0
YLTWPDHGCPLHPYAVLNFLEDVDREYdyfnaqpiaASLPQGPIVVHCSAGIGRTGTVLVLdALLNQvkkvgllCPMDVYKMVKYVRTYRSGLVQTEQQY
 | .||.|..     .|.||. ||. .         .  |.| ..||| ||.|||||...  .|.         . |.. . ....|  | | ... ...
klpfpddgtvPsleillrfldlvdefl.........nedpggvvaVHCkaGlgRtGtlvaa.YLiyr.......lgmsaeeAialfrekRpgaipnqdyl

QFLYKALAFYLKN
. |.|   .. |.
eallkrykelrka
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 302-414 3.8e-11 37.6 In-house 28-141 (290) alignment 
Range on Protein: 302-414
Range on HMM: 28-141/290.0
VPFDHTRVILTDRPNTPGSDYINASYVRFENSQRTKNVTFACEKSfiatQGCLETTISDFWSMVWQENSRVIVMPTMENERKEK-----CARYWPAEVNK
  . .|||.| .  .   .||| |..| . | .|        ||         . || .|| |. ||... .||    .|....     ||.| | .|..
pLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqeki....tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

PEVHGDISLTCTIERKVQ
    ..... |.   |..
elkfkgltvkCkskeked
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 514-582 2.4e-10 34.7 In-house 1-66 (69) alignment 
Range on Protein: 514-582
Range on HMM: 1-66/69.0
IVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
.|||||.| ||||| . .   . ..|   |   .|..  |.|.|  |  .|  |..| |.. ||.  ||
mvvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 292-373 3e-10 34.2 In-house 37-113 (347) alignment 
Range on Protein: 292-373
Range on HMM: 37-113/347.0
NAEKNRYKNIVPFDHTRVILTDR-----PNTPGSDYINASYVRFENSQrtknvtfaceKSFIATQGCLETTISDFWSMVWQENSRVI
. .||| |.    | |||.|.       .  .   |||||...|.|..          | .| ||  |  |. ||| ||   .   .
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnas..........keyiltqyplpdtvrdfwkmvsvtkvtqv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 515-582 4.1e-10 33.9 In-house 1-65 (69) alignment 
Range on Protein: 515-582
Range on HMM: 1-65/69.0
VVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLK
|||||.| ||||| . .   . ..|   |   .|..  |.|.|  |  .|  | .| |.. ||.  ||
vvhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_eak_pd Subfamily eak 280-408 4.7e-10 33.4 In-house 40-157 (332) alignment 
Range on Protein: 280-408
Range on HMM: 40-157/332.0
QYLSKREGRRPVNAEKNrYKNIVPFDHTRVILTDRPNTPgSDYINASYVRFENsqrtknvtfaCEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTME
. ||..|..|  . ..|   .|||.|.  | ||     .   ||||| . | .            . .| |    |. .  || || ...|  ||.   .
rllsisetarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefse..........vGrkyiltGiasedkvfafwqmvleqkspaivqlled

NERK-EKCARYWPAEVNKPEVHGDISLTCT
 | | ||  .|.| .  .   .| . ... 
velkleksdkyfpdktreelkfGildverk
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 344-397 6.9e-10 33.1 In-house 89-143 (301) alignment 
Range on Protein: 344-397
Range on HMM: 89-143/301.0
EKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNKP
 . |||||| |. |  ||| |. | .   ||| . . |. .|||. | | .... 
phrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisek
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 288-338 2.4e-09 31.0 In-house 43-93 (440) alignment 
Range on Protein: 288-338
Range on HMM: 43-93/440.0
RRPVNAEKNRYKNIVPFDHTRVILTDRPNTPGSDYINASYVRFENSQRTKN
  | |  ||||.||. .||.||.| .    | ||||||||.   .|.  |.
slpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingiesrtlkq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 344-413 2.6e-09 31.5 In-house 4-75 (199) alignment 
Range on Protein: 344-413
Range on HMM: 4-75/199.0
EKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERKE-KCARYWPAEVNKPEVHGDISLTC-TIERKV
.. .||||  |  |..||| |||.  |  |||   ..  ||   . |||.  .    .| .|.|. ||  | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 289-330 2.7e-09 31.0 In-house 36-76 (244) alignment 
Range on Protein: 289-330
Range on HMM: 36-76/244.0
RPVNAEKNRYKNIVPFDHTRVILTDRpNTPGSDYINASYVRF
  .|| |||| ||.|||.|||||.   .  |||||||.|.. 
lsanatknryinilpfdetrvilsss.kkegsdyinanyiqg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 345-413 2.8e-09 31.4 In-house 4-74 (198) alignment 
Range on Protein: 345-413
Range on HMM: 4-74/198.0
KSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERKE-KCARYWPAEVNKPEVHGDISLTC-TIERKV
. .||||  |  |..||| |||.  |  |||   ..  ||   . |||.  .    .| .|.|. ||  | 
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 512-577 3.5e-09 30.7 In-house 201-265 (281) alignment 
Range on Protein: 512-577
Range on HMM: 201-265/281.0
GPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLLcPmDVYKMVKYVR-TYRSGLVQTEQQYQFLYKAL
 | |.|||||.||.||.. ..  |. ..    | | |. ..| ..| | |.  ||| ||| ...| |
tppvihcsagvgrsgtlmaveialqsihshftl.p.dikqivshlrvtgraasvqtlqqymliwkvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 514-587 5.5e-09 29.9 In-house 221-291 (302) alignment 
Range on Protein: 514-587
Range on HMM: 221-291/302.0
IVVHCSAGIGRTGTVLVLDALLNQVKKVGLLCPMDVykmVKYVRTYRSGLVQTEQQYQFLYKALAFYLKNNNPY
.|.    |.|| |..|.| . .....|    .  ..   || .|. |.  |.. .|| .|| ||..|.|..   
tvivSknGaGRagafltlavaveklqkgkepnikei...vksiRsqRpravdslkQyvslyialllyikkkvtk
PTEN_1 507-574 2.5e-08 28.9 In-house 125-186 (196) alignment 
Range on Protein: 507-574
Range on HMM: 125-186/196.0
ASLP-QGPIVVHCSAGIGRTGTVLVldALLNQVKKvgllcpMDVYKMVKYVRTYR-SGLVQTEQQYQFLY
 |.| .. ..||| ||.||.|||.   |.| . .|      ... . ...||  |  | ... .| ..|.
lsdpngnvVlVHCkaGlgRsGtvva..ayLmykgk......ltadeAlelvrekRppgapnspsqerlle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 287-329 6.8e-08 26.6 In-house 43-82 (95) alignment 
Range on Protein: 287-329
Range on HMM: 43-82/95.0
GRRPVNAEKNRYKNIVPFDHTRVILTDRPNtpgSDYINASYVR
|    |  |||. ||.|.| |||.|| . .   |||||| .| 
gsseanipknrflnifpydatrvvlttkrd...sdyinacfvd
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 461-575 8.7e-08 26.6 In-house 92-198 (199) alignment 
Range on Protein: 461-575
Range on HMM: 92-198/199.0
KDTREIRQLQYLTWPDHGCPLHPYAVlNFLeDVDREYDYFNAQPIAAslpqgPIVVHCSAGIGRTGTVLVLDALLNQVKKvGLLCPMDVYKMVKYVRTYR
  |||| . |. .| ..  |     |  |.    ||      |   |     |..|||| | | ||  . ||  .   ..      .|.... | .|  |
pstreishyqftswkekttpnvalfv.gfv.vasrevskkyeqekda.....pvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqar

SGLVQTEQQYQFLYK
 |.. . |.|.|.|.
cgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 461-575 8.7e-08 26.6 In-house 91-197 (198) alignment 
Range on Protein: 461-575
Range on HMM: 91-197/198.0
KDTREIRQLQYLTWPDHGCPLHPYAVlNFLeDVDREYDYFNAQPIAAslpqgPIVVHCSAGIGRTGTVLVLDALLNQVKKvGLLCPMDVYKMVKYVRTYR
  |||| . |. .| ..  |     |  |.    ||      |   |     |..|||| | | ||  . ||  .   ..      .|.... | .|  |
pstreishyqftswkekttpnvalfv.gfv.vasrevskkyeqekda.....pvivhcsdgqgftgvfvaldigvrshee.sktsvvdlfevakrlrqar

SGLVQTEQQYQFLYK
 |.. . |.|.|.|.
cgiisslqhynfiyq
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 512-581 9.2e-08 26.4 In-house 204-270 (285) alignment 
Range on Protein: 512-581
Range on HMM: 204-270/285.0
GPIVVHCSAGIGRTGTVLVLDALLNQVKKVgllCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL
 ||.||||||.||| |.. .|    .. .      ...  .|. .|. |   ||.  |. |||  |  |.
kpicvhcsagvgrtatfvgidyatirimen...pniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 291-375 9.4e-08 26.0 In-house 46-113 (303) alignment 
Range on Protein: 291-375
Range on HMM: 46-113/303.0
VNAEKNRYKNIVPFDHTRVILTDrpntpgSDYINASYVRFENSQRTknvtfaceksfIATQGCLETTISDFWSMVWQENSRVIVM
 | .|||. ... .||..| |.|      | || |||. .. |...           | ||  |  | .||| |. ... .....
knmdknrfvdvicldhskvklsd......ssyihasyleldsskka...........iltqlplshtaadfwqmiieqkvkcvll
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 462-573 1.5e-07 25.5 In-house 179-273 (301) alignment 
Range on Protein: 462-573
Range on HMM: 179-273/301.0
DTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnaqpiaaSlpQGPIVVHCSAGIGRTGTVLVLDALLNQVKKVGLlcpMDVYKMVKYVRTYRS
.|| .   || .|.|.| |     . ...| | .            |  . ||||||||||||. . .  . | ..|.       ... . .| .|  | 
atrtvthyqysewtdrgvPkshaelfdlmelvkk............s..ekPivvhcsaGiGrsvafigteylareveadpt...ieltealkhlrehrw

GLVQTEQQYQFL
  |||..|  ..
ngvqtnsqlywm
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 502-577 2.3e-07 24.7 In-house 214-286 (310) alignment 
Range on Protein: 502-577
Range on HMM: 214-286/310.0
AQPIAASLPQGPIVVHCSAGIGRTGTVLVLDALLNQVKKvGLLcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKAL
 | . | . .|| |||||||..|...|. |.  ...... ||   .|. ...  ..  |   .||| || .. .  
pqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldr.glk..vdaeevktellksraiciqtelqyliidrvr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 354-409 2.6e-07 25.0 In-house 39-93 (255) alignment 
Range on Protein: 354-409
Range on HMM: 39-93/255.0
LetTISDFWSMVWQENSRVIVMPTMENE-RKEKCARYWPAEVNKPEVHGDISLTCTI
|  |.  |. .. | .. |.|| .  .|  .||| .|.| | ..  .  |...|.| 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk
subfamily_hpo-7_pd Subfamily hpo-7 354-412 3.5e-07 24.4 In-house 43-102 (263) alignment 
Range on Protein: 354-412
Range on HMM: 43-102/263.0
LETTISDFWSMVWQENSRVIVMPTMENER-KEKCARYWPAEVNKPEVHGDISLTCTIERK
|  ||  |.... | .. |.|| .  ||  .||| .|.| | ..  .  ......|   .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs
subfamily_CDC14_pd Subfamily CDC14 511-575 1e-06 22.9 In-house 263-318 (328) alignment 
Range on Protein: 511-575
Range on HMM: 263-318/328.0
QGPIVVHCSAGIGRTGTVLVlDALlnqVKKVGllcpMDVYKMVKYVRTYRSGLVQTEQQyQFLYK
.| |.||| ||.|||||..    |   .|. .    .    .. ..|  | | | . || .||..
eGaiavhCkaGLGrtGtLia.cyl...mkhyr....ftaaeaiawlricrPGsvigpqq.kflee
subfamily_PTPDC1_pd Subfamily PTPDC1 506-581 1.5e-06 22.7 In-house 109-176 (182) alignment 
Range on Protein: 506-581
Range on HMM: 109-176/182.0
AASLPQGPIVVHCSAGIGRTGTVLVldALLNQVKKvgllcpMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYL
| .| .| . ||| || |||| ..   . |  .|.      ..  | .| ||  |.  .|| .| ... .  .| .
afalqegkvavhChaGlGrtGvlia..cylvyakr......ltaekaiklvrskrpksiqtreqvelvkefalfli
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 453-579 1.7e-06 22.3 In-house 101-220 (255) alignment 
Range on Protein: 453-579
Range on HMM: 101-220/255.0
RTL----VMKKGKDTREIRQLQYLTWPDHGCPLHPYAVLNFLEDVDReydyfnaqpiaaSlpqGPIVVHCSAGIGRTGTVLVLDALLNQ-VKK--VGLLC
|||     . . | |....  .|  |...  |  .  .|| |  |              |    ..|||||.||||. .  . . .  . ..        
rtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrd............s...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetv

PMDVYKMVKYVRTYRSGLVQTEQQYQF-LYKALAF
 .|  .... .|  |.. ..|  |  | ..  | .
eldylslleelrskrkraihtPlqlafsilmvldl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 341-393 2.1e-06 21.3 In-house 232-282 (440) alignment 
Range on Protein: 341-393
Range on HMM: 232-282/440.0
FACEKSFIATQGCLETTISDFWSMVWQENSRVIVMPTMENERkeKCARYWPAE
..  ..|||||  |..|. ||| .| . .   |.|    |..   |. ||| .
yskknafiatqmpldstvldfwrlvhdyristiimlnqlndk..tcsiywpvn
SH2_2 SH2 domain 10-66 2.8e-06 14.4 Pfam-A 39-94 (220) alignment 
Range on Protein: 10-66
Range on HMM: 39-94/220.0
NFYYRVNGEKAEELLKEYgEDGDFLLRYSESNPQNFSISVRVAEDKILHIKVTKYES
 ... .|...||..|..  . ||...| |    . . .  .||..   || |   | 
Plfkdlnakqaekylesm.dqGdlvirpsskGedhlvvtWkvadgiyqhidvrelek
subfamily_egg_pd Subfamily egg 512-583 6.7e-06 20.0 In-house 202-272 (307) alignment 
Range on Protein: 512-583
Range on HMM: 202-272/307.0
GPIVVHCSAGIGRTGTVLVLDALLNQVKKvGLLCPMDVYKMVKYVRTYRSGLVQTEQQYQFLYKALAFYLKN
 |.||..  |. ...|.. ..  | .. . | .    | . |...|  |   |..  .| |.|. ..|....
kpvvvqdilGvskaatlvaieiallsllr.Gpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd