Gene ptp-4 in Caenorhabditis elegans

Synonym: CELE_K04D7.4, ptp-4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP162_AA protein Get Run
CeleP162_AA_625-905 phosphatase_domain Get Run
CeleP162_AA_914-1154 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPRD_pd Subfamily PTPRD 621-944 1.2e-99 329.5 In-house 3-322 (564) alignment 
Range on Protein: 621-944
Range on HMM: 3-322/564.0
EDIPVELFYGYVEDLNRNDSLKFKTQFQILESQtsgiDSVDsgESNSSSDENSQKNRYNNIGAIEATRIRLNS---PTGNDYINANYVDSCNERNAYIAT
. |||. .  .|. |. |..|||..... .|..    ...    .... ..| .||||.|| | ...|..|..     | |||||...|. ..|.|||||
kpipvaelkehvaklkansdlkfeeeykkieeg....qqft..weaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAt

QAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqDsPQTFGNYQVTLVSESTNAHFSHRILDLkiAKAVPAVERKVHQLHFMGWPDHGV
|.||..|..||| |.|...|..|| .|...| || ||..|||.. . ..|.|...|||..| . |... | . |   |.     |.|.| ||. ||||||
qgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfkl..kkkkssesreVrqFhFtsWPdhgv

PSSVFPLLSFVHYTSDIH--STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDL
| |  .||....  ....   .||.||||||||||.| .| .|.| . . . . ... ......|.||  .||| |||||.|||| . .  | | |.|. 
pesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesen

FMRYLHYLSEENLN-GKTRMQLQFEDICDC
. . |. |.| . . . | ..| |. .  .
lkqhlqkLaeveedtemtgleleFqrLata
0050432 (Phosphotyrosine protein) phosphatases II 634-909 3.7e-88 291.1 In-house 37-304 (308) alignment 
Range on Protein: 634-909
Range on HMM: 37-304/308.0
DlnRNDSLKFKTQFQILESQTSgidsvDSGESNSSSDENSQKNRYNNIGAIEATRIRLnsPTGNDYINANYVDSC--NERNAYIATQAPLPSTFSDFWSM
.   .|. .....|. | |..      .   | ..  ||  |||| .| . . .|..|  . |.|||||.||| .  . ....||||.|||.|. ||| |
k..aldlglleeefeellsvkp.....lleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrm

IWQERSNIIVCITNMVEDGKRKCDQYWPSQQD-SPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVpaVERKVHQLHFMGWPDHGVPSSVFPLLSFVHY
.|......||..|. ||.|. ||.||||. .. .....|...|||.|| ..... .| | |.  .     .|.|...|...|||||||.|. .||.|...
vweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflel

TSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGIT
  . .. ||.||||||||||.| .|..| . ..|   ....|.. . ..|.||.  |||.|||.|...|.  ...  .|
vrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 621-904 2.1e-87 288.5 In-house 3-286 (288) alignment 
Range on Protein: 621-904
Range on HMM: 3-286/288.0
EDIPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGidsvdSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIAT
 .|.|| .. .|. | .|.  ... .|. | |..          | ..  || .|||| .| . . .|..|... |   .|||||.|.| .|  ...|||
teisveellklvlkllangltglleefeellsllpd.....ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAK--AVPAVERKVHQLHFMGWPDH
|.|||.|..||| |.|......||..|. ||.|..||.||||.  ....|.|...|||.|| ..... .| | ..  .    .  .|.|...|...||||
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdh

GVPSSVFPLLSFVHYTSDI--HSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
|||.|. .||.|...  .   .. |||||||||||||.| .|..| . ..|   ....| . . ..|.||  .|||.|||.|..||.  ..
gvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 646-909 3.5e-85 281.1 In-house 5-279 (284) alignment 
Range on Protein: 646-909
Range on HMM: 5-279/284.0
QFQILESQTSGIDsvdSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG----NDYINANYVDSC-----NERNAYIATQAPLPSTFSDFWSMIWQER
.|. | |.|  .       | .   ||  |||| .| . . .|..|.|. |    .|||||.||| .     . ....||||.|||.|. ||| |.|...
efeellsltvkll...lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SNIIVCITNMVEDGKRKCDQYWPSQqDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAkAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS
...||..|. ||.|. ||.||||.  ....|.|...|||.|| .. .. .| | |.    ..  .|.|...|...|||||||.|. .||.|...  ....
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswpdhgvppspedlleflrlvrelle

----TGPVVVHCSAGVGRSGSYILVDSMRRHLISFR---RLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGIT
     ||.||||||||||.| .|..| . ..|.  .   ...|.. . ..|.||   |||||||.|..||.  ......|
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPRG_pd Subfamily PTPRG 623-918 4.5e-85 281.0 In-house 1-301 (563) alignment 
Range on Protein: 623-918
Range on HMM: 1-301/563.0
IPVELFYGYVEDLNRNDSLKFKTQFQILESQTSgIDSVDsgESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---N-DYINANYVDSCNERNAYIATQ
.||. |  .| .|  ..  .|. .|. |.|.|   ...|   . |.  || .|||| || |.. .|..|.. .|   . |||||||.|  .  .|.||||
vpvkefakhvaslhadgdigfseefealqseti.skdld..aehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatq

APLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqDSPQTFGNYQVTLVSESTNAHFSHRILDLKI--AKAVP--AVERKVHQLHFMGWPD
 ||..|| ||| |||.....||| |||.||.|.||||.|||.  | ..|.|. ||||..| . |  . | | .|    |.      |..| | |.  |||
gplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPd

HGVPSSVFPLLSFVHYTSDIHST--GPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH
||||..  | |.||.  |  . .  ||.||||||||||.| || .|.. . . .    || | | |.| ||  |||| ||||| |.|. ..|. . | . 
hgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell

SDLFMR
..   .
aeqvee
0040438 (Phosphotyrosine protein) phosphatases II 629-920 6.4e-85 280.5 In-house 6-292 (317) alignment 
Range on Protein: 629-920
Range on HMM: 6-292/317.0
YGYVEDLNRNDSLKFKTQFQILESQtsgidSVDsGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTF
. ...||...|  ... .|. | |.     ..|   | ..  || .|||| .|   ...|..|....|   .|||||.|||  |.....||||.|||.|.
llalldllksdftalleefedllsl.....kld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntv

SDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAkaVPAVERKVHQLHFMGWPDHGVPSSVFPLL
 ||| |.|......||..|. .|.|..||.||||.  ....|.|...|||.|| ..|.. .| | ..        .|.|...|..||||||||.|  .||
edFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdlll

SFVHYTSDI--HSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFMRYL
.|...  .   .. |||.|||||||||.|..|... | ..|   ....|.  . ..|.||.. |||.|||.|...|.........|..    ....|
dfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl
subfamily_PTPRB_pd Subfamily PTPRB 621-907 2e-84 278.1 In-house 5-288 (293) alignment 
Range on Protein: 621-907
Range on HMM: 5-288/293.0
EDIPVELFYGYVEDLNRNDSLKFKTQFQILESQTSgidsvDSGESNSSSDENSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYVDSCNERNAYIAT
..| .| | ..|....... |.|. ... |..  .     |   . ... .|..||||.|| . ...|..|   .. .|.|||||||..  | .. .|||
kpiklekfeehvkkmkadsdlrfseeyeelkavgk.....dqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiat

QAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQdSPQTFGNYQVTLVSESTNAHFSHRilDLKIAKavPAVERKVHQLHFMGWPDHGV
| |||.|. ||| |.|...|.||| .|..|| || ||..|||... .|...|. .||||.|..  ..  |  .||| |     ||||.|.||. ||||||
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvir..elkiek..ekeerkvrqyhftsWpdhgv

PSSVFPLLSFVHYTSDIH----STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHG
|..  .||.||.   . .    |..|.||||||||||.| .| .| . ... .   ... | ....|..|. |||| .|||| |... .|.|..
PektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
0036941 (Phosphotyrosine protein) phosphatases II 661-910 5.9e-84 277.2 In-house 28-283 (297) alignment 
Range on Protein: 661-910
Range on HMM: 28-283/297.0
DSGESNSSSDENSQKNRYNNIGAIEATRIRLnSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPS
.   | ... || .|||| .| . . ||..| .. |.|||||.||| ..  ...||||.|||.|. ||| |.|......||..|. ||.|. ||.||||.
lgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpl

QQDSPQTFGNYQVTLVSEST--NAHFSHRILDLKIAKAVpaVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH----STGPVVVHCSAGVGRSGSY
 .....|.|...|||.|...  ....  | | ..  .     .|.|...|..||||||||.|. .||.|...  ...    | |||.|||||||||||..
eegesltygdftvtllsvevvllddytlrtlevtdtgng..esrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtf

ILVDSMRRHLI---SFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITR
|..| | . |      .....   . ..|.||.  |||||||.|..||. .|.... |.
iaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
DSPc_SM00195 643-904 3.1e-83 274.5 In-house 2-262 (263) alignment 
Range on Protein: 643-904
Range on HMM: 2-262/263.0
FKTQFQILESQTSGIdsvdsGESNSSSDENSQKNRYNNIGAIEATRIRLNSP---TGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNI
.|..|. ||..||         ...  ..|..||||.||  .. ||..|...   .|.|||||||..  |....|||||.|||||..||| |.|.|...|
lkeefekleestspk.....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvki

IVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNA-HFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS--
||..|. .|.||.|||.|||.......|||...|.||.. .   ..  | | |.  .     .|||.|... .|||||||.|  ..|.....    .|  
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts

TGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
.||.||||||||||.|.....|.. ..| .  .....  ....| ||...|||||||.|..||| ..|
sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 643-904 3.1e-83 274.5 In-house 2-262 (263) alignment 
Range on Protein: 643-904
Range on HMM: 2-262/263.0
FKTQFQILESQTSGIdsvdsGESNSSSDENSQKNRYNNIGAIEATRIRLNSP---TGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNI
.|..|. ||..||         ...  ..|..||||.||  .. ||..|...   .|.|||||||..  |....|||||.|||||..||| |.|.|...|
lkeefekleestspk.....etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvki

IVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNA-HFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS--
||..|. .|.||.|||.|||.......|||...|.||.. .   ..  | | |.  .     .|||.|... .|||||||.|  ..|.....    .|  
ivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstksvlellravkksksts

TGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
.||.||||||||||.|.....|.. ..| .  .....  ....| ||...|||||||.|..||| ..|
sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0047943 (Phosphotyrosine protein) phosphatases II 637-903 1.3e-82 272.6 In-house 8-271 (273) alignment 
Range on Protein: 637-903
Range on HMM: 8-271/273.0
RNDSLKFKTQFQILESQTSgidsvDSGESNSSSDENSQKNRYNNIGAIEATRIRLnSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQER
.... ... .|. | |..      .   | ..  || .|||| .| . . .|..| .. |.|||||.||| .|  ...||||.|||.|. ||| |.|...
llgltllleefelllslkp.....lltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqn

SNIIVCITNMVEDGKRKCDQYWPSQQDS-PQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPavERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH
...||..|. ||.|..||.||||. ... ..|.|...|||.|| |.... .| | |.  .     .|.|...|..||||||||.|. .||.|...  ...
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwpdhgvppslesllefielvrkal

----STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
    | |||||||||||||.|..|..| . ..|.  ....|   . ..|.||   |||.|||.|..||.  .
ealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 623-940 1.8e-81 268.7 In-house 2-317 (318) alignment 
Range on Protein: 623-940
Range on HMM: 2-317/318.0
IPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGIDSVDSgesnsSSDENSQKNRYNNIGAIEATRIRLNSP---TGNDYINANYVDSCNERNAYIATQA
|.|| .   |. |... .|....... |. ... . |..|      .. | .||||.|| | . ||..|.     .| |||||||.|  ....||||.||
isvedleshvrrlresGelllseeyerlsrseetvtslks.....lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqa

PLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQdsPQTFGNYQVTLVSESTNAHFSHRILDLKIakAVPAVERKVHQLHFMGWPDHGVPS
||| |..||| |.|.  | .|| .|...| ||.|...||||..  ....|. .|.| .| . ...  | . ..        .|.|.| |.  |||.|||.
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpdegvpe

SVFPLLSFVHYTSDIH---STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH-SDL
|.  ||..|  .| ..   ..||.|||||||||| | .| ||.. ...     ..| .  ...|.||  .||| .||.|..... . .  | | |. |||
sgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdl

FMRYLHYLSEENLNGKTRMQLQFED
  |  .   ...  |.|.|...|. 
rsrirelreqdpesgttemdaefqr
0039614 (Phosphotyrosine protein) phosphatases II 620-909 4.1e-81 268.0 In-house 11-294 (297) alignment 
Range on Protein: 620-909
Range on HMM: 11-294/297.0
QEDIPVELFYGYVEDLNRNDSLKFKTQFQILESQTSgidsvDsgESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG----NDYINANYVDSCNE-RNAY
 ..||.. .  ..  ...|.. .....|. | |..      |   | . . ||  |||| .| . . .|..|... |    .|||||.|||  .   ...
sipiplsvldlllllekansktllllefeellslkp.....d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

IATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKrKCDQYWPSQQDspqTFGNYQVTLVSESTNAHFSHRILDLKIakavPAVERKVHQLHFMGWPD
||||.|||.|. ||| |.|......||..|. ||.|. ||.||||. ..   |.|...|||... ..... .| | ..        .|.|......||||
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwpd

HGVPSSVFPLLSFVHYTSDIH----STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGIT
||||.|.  ||.|...  ...    . |||.|||||||||.|..|. . | ..| . ....|.  . ..|.|| . |||..||.|...|...|.... |
hgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0045450 (Phosphotyrosine protein) phosphatases II 623-905 5.4e-81 268.0 In-house 9-305 (307) alignment 
Range on Protein: 623-905
Range on HMM: 9-305/307.0
IPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGIdsvDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG----NDYINANYV--------DSCNE
|... .. .|  | ...  ... .|. | |.|  .       | ... ||  |||| .| . . ||..|.|..|    .|||||.||        |... 
idalkllllvllllldfltgllkefekllsvtvfl...lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

RNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAkAVPAVERKVHQLHFM
 ...||||.|||.|. ||| |.|......||..|. ||.|..||.||||.  ....|.||..|||.||.. ... .| | ..        .|.|...|. 
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhyt

GWPDHGVPSSVFPLLSFVHYTSDIH----STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRR---LNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
||||||||.|. .||.|...  ...    . |||.|||||||||.|..|. . | |.| .      ....  . ..|.|| . ||..|||.|..||...|
gwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

IR
..
ll
0043336 (Phosphotyrosine protein) phosphatases II 624-904 7.2e-78 257.1 In-house 3-277 (278) alignment 
Range on Protein: 624-904
Range on HMM: 3-277/278.0
PVELFYGYVEDLNRNDSLKFKTQFQILESQTSgidsvdSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAP
.|. .. ....|..|.  ... .|. | |..          | . . || .|||| .| . . .|..|.. .|   .|||||.|||  |  ...||||.|
svkdllkallelllnlktllllefeellsfkl......dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgP

LPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPsqqDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAveRKVHQLHFMGWPDHGVPSS
||.|. ||| |.|......||..|. ||.|. ||.||||   ....|.|...|||..| ..... .| | ..  .  .   |.|...|..||||||||.|
lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwpdhgvpes

VFPLLSFVHYTSDI--HSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
. .||.|...  ..  .| |||.|||||||||.| .|... . ..| . ......  . ..|.||.. |||..||.|..||.....
lsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 672-900 1.8e-76 252.0 Pfam-A 1-233 (235) alignment 
Range on Protein: 672-900
Range on HMM: 1-233/235.0
NSQKNRYNNIGAIEATRIRL-NSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGN
|..||||..| ... ||..| .|.. .||||||||.. .| ...||||.||.||..||| |.|||....||..|. .| |..||.||||.... ..|.|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YQVTLV-SES-TNAHFSHRILDLKIAKAVPaVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH--STGPVVVHCSAGVGRSGSYILVDSMRRHLIS
..|.|. .|.  ....  | |.||  |.    .|.|.|||. .|||||||.|. .||....     .  ..|||||||||||||.|.....| . ..| .
ikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

FRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
 . ..|   . ..|.||...||.||||||...||
eeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 672-900 1.8e-76 252.0 In-house 1-233 (235) alignment 
Range on Protein: 672-900
Range on HMM: 1-233/235.0
NSQKNRYNNIGAIEATRIRL-NSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGN
|..||||..| ... ||..| .|.. .||||||||.. .| ...||||.||.||..||| |.|||....||..|. .| |..||.||||.... ..|.|.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

YQVTLV-SES-TNAHFSHRILDLKIAKAVPaVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH--STGPVVVHCSAGVGRSGSYILVDSMRRHLIS
..|.|. .|.  ....  | |.||  |.    .|.|.|||. .|||||||.|. .||....     .  ..|||||||||||||.|.....| . ..| .
ikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

FRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
 . ..|   . ..|.||...||.||||||...||
eeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 636-906 4.6e-76 250.6 In-house 16-282 (288) alignment 
Range on Protein: 636-906
Range on HMM: 16-282/288.0
NRNDSLKFKTQFQILesqtSGIDSVDSGEsNSSSDENSQKNRYNNIGAIEATRIRLNS---PTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMI
....   |. ... |    . ... .|..  ..  .| .||||.|| ... .|..|.     .|.|||||.|.|. .....|||||.||..|  ||| ..
sarnrtgfseeynsL....aalektksvt.agrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelv

WQERSNIIVCITNMVEDGKRKCDQYWPSQqDSPQTFGNYQVTLVSESTNAHFSHRILDLKiakaVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTS
...... || .|..||.||.||..|||.. | |. .|. .||||.. .  .| .| | |.        |....|.....||||||| |  ||| ...   
yenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhgvPeskapllellrqvk

DIH--STGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI-RH
  .   |||..|||||||||.| .| .| .  .. .   ..| | ....|.||| |||||.||.|..|.. .|| ..
vanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
0045098 (Phosphotyrosine protein) phosphatases II 666-907 3.9e-74 244.8 In-house 27-275 (278) alignment 
Range on Protein: 666-907
Range on HMM: 27-275/278.0
NSSSDENSQKNRYNNIGAIEATRIRlnsptgnDYINANYVDSCneRNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqDSP
..   .|  |||| .| ... .|..       |||||.|.|..  ....||||.|||||..||| |.|......||..|. ||.|. ||.||||.  ...
palylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggs

QTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAV--ERKVHQLHFMGWPDHGVPSSV--FPLLSFVHYTSDIH---------------STGPVVVHCSA
.|.|...|||.||... .. .| | .      ..   .|.|..||...||||||||.    ..|... .  . .               | |||.|||||
ltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsa

GVGRSGSYILVDSMRRHLiSfRRLNVQGHLTHMRRQRAK-LVQTLEQYIFCHEAIRQLIRHG
||||.| ..... |...|   ......  ....|.||    ||.||||.|..|....|...|
GvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 620-937 2.1e-73 242.2 In-house 2-317 (319) alignment 
Range on Protein: 620-937
Range on HMM: 2-317/319.0
QEDIPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGidsvdsGESNSSSDENSQKNRYNNIGAIEATRIRLNSP---TGNDYINANYVDSCNERNAYIA
...|.|. .  ... |. . . ... .|. |.  ..         ...| .||..||||.|| |.. ||. | .     | |||||...|. .||...||
dteievqeLkerlkalastgetllekefkllkeavnd......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfia

TQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQdsPQTFGNYQVTLVSESTNAHFSHRILDLkiAKAVPAV-ERKVHQLHFMGWPDH
|||||  |..||| |.|.|.| |.| .|..|| .| |. .|||...  ....|.. ||| .|   ...  | | |   |.   |  |.| . ... ||||
tqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklkl..nkkssevetRevkhfqyteWpdh

GVPSSVFPLLSFVHY---TSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH
.|| .   || ...    . . .. ||.|||||||||| |..| .| |  ..     |.|     ..| ||  .||. |||.|..||... .  | | ..
dvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteie

-SDLFMRYLHYLSEENLNGKTRMQLQ
  || .|  .  . .   |.| .. .
vqdlrdrlkqlaekvadtgetglere
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 632-905 2.6e-73 241.6 In-house 6-277 (281) alignment 
Range on Protein: 632-905
Range on HMM: 6-277/281.0
VEDLNRNDSLKFKTQFQILESQtsGidsVDSGESNSSSDENSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDF
...|..||.  |..... |..   |   ||.  . | .||| .||||.|| | .|||...   .. . .||||||.|.. .. ..|||||.|.|... .|
lkqlsqndnaGfieeyeklaai..g...vdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvaf

WSMIWQERSNIIVCITNMVEDGKRKCDQYWPsQQDSPQTFGNYQVTLVSESTNAHFSHRILDLkiaKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFV
| |.|... ..|| .|. .| || || .||| ...|  ..|...|. ..|...|.. .| . |   ..  . .|.|.||... |||||||..   ||.| 
WqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPdhGvPattkellefr

HYT---SDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHL-ISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIR
.     .. ..  |.|.||||||||.|.|| .| . ...  . ..|.|.  ....|..|  .|||. || | . |. . . 
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 624-911 3.4e-73 241.5 In-house 5-290 (305) alignment 
Range on Protein: 624-911
Range on HMM: 5-290/305.0
PVELFYGYVEDLNRNDSLKFKTQFQILESQtsgIDSVDSGEsnssSDENSQKNRYNNIGAIEATRIRLNSPTGND---YINANYVDSCNERNAYIATQAP
 .. .  |... . ... ....|.. | ..    .|.| |.    ...| .|||...|   .  ||.|.    .|   ||||.|||. .....||..|.|
alddlaayikearvysdkgleaqykslyee...eesidvgk....keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgP

LPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvPAVERKVHQLHFMGWPDHGVPSS
|..| .||| .|..|. . || .|..||.|| || |||| ..  .. ||...|.| ||.| . .  | | . |..     .| | |...  ||||||| .
lkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.dkesrtvlqyqltdWPdhGvpqf

VFPLLSFVHYTSDIHSTG---PVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRV
   |||...     .. .   |..|||||||||.| .| || .  .|     ..| . | ..|..| |.||||.|| |.|.|. .||  | | .
atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsi
0040439 (Phosphotyrosine protein) phosphatases II 668-905 1e-72 240.0 In-house 7-247 (249) alignment 
Range on Protein: 668-905
Range on HMM: 7-247/249.0
SSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqDS
.  ||  |||| .| . . .|..|..  |   .|||||.|.| ..  ...||||.|||.|..||| |.|......||..|. || |. ||.||||.  ..
llpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..gg

PQTFGNYQVTLVSESTNAHFSHRILDLKIAkaVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH----STGPVVVHCSAGVGRSGSYILVDSM
....|...|||.|. ..... .| | |.        .|.|..... .|||||||.|. .||.|...  ...    . |||.|||||||||.| .|. . |
sleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

RRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIR
 ..|   ......  . ..|.|| . ||..|||.|..||...|..
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 636-909 2e-72 239.0 In-house 22-295 (298) alignment 
Range on Protein: 636-909
Range on HMM: 22-295/298.0
NRNDSLKFKTQFQILESQTSGIDSVDsgESNSSSDENSQKNRYNNIGAIEATRIRLNS---PTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMI
....  .....|| |.| .| |..     . ....|| .|||| .| |.. .|..|..       ||||| .... ..|||.|||||||..|..||| |.
kkkkltgyalefqrlnsvsseieeee..kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmv

WQERSNIIVCITNMVEDGKRKCDQYWPSQQdsPQTFGNYQVTLVSESTNAHFSHRIldLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSF---VH
..| .. || .||..| .| |. .|||...   .|.|. .|.| |. . | .  |   ||..|.  . ||.|.||||. |||.|||.    .| .   |.
teedigtiVmltnleeldktkyhkywPdeg..ketygeitvsllskeefadlivrk..lkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr

YTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGIT
 .       ||.|.|||||||||..| .||.  ..   . . |   .  .|..|...||| |||.|..||. . .  . .
asqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd
0042113 (Phosphotyrosine protein) phosphatases II 667-904 8.7e-72 236.7 In-house 4-243 (245) alignment 
Range on Protein: 667-904
Range on HMM: 4-243/245.0
SSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqD
..  || .|||| .| . . ||..|... |   .|||||.||| ..  . .||||.|||.|. ||| |.|......||..|. .|.|. ||.||||.  .
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

SPQTFGNYQVTLVSESTNAHFSHRILDLKIakAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH---STGPVVVHCSAGVGRSGSYILVDSM
...|.|...|||.|| ..... .|.| ..        .|.|...|...|||||||...  ||.|...  ..    | |||.|||||||||.| .|... |
esltygdftvtllseehlddytvrtlevtn..lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

RRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
 ..| . ......  . ..|.|| . |||..||.|..||...|.
leqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 639-911 1.4e-69 229.2 In-house 6-284 (290) alignment 
Range on Protein: 639-911
Range on HMM: 6-284/290.0
DSLKFKTQFQILESQTSGIDSVD-SGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQ
 . .|...|| | ....   . .    ......|| .|||| .|   . .|. |.  ..   .||||||..   ... .|||.|.||| | .||| |||.
geeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwe

ERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNA-HFSHRILDLKIAkavpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSD
 . .|.| . ..|| || ||..|||...... .||...||| .| .    |  | | ..        .|||.|.|.. |||||||||. .||....   .
knveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq....kesrkvyqfhYtaWPDhgvPssaksllelielvre

IHS--TGPVVVHCSAGVGRSGSYILVDSMRRHLISFRR---LNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRV
...    |.|||||||||| |  | .| .|. | . .    |.|   ....|.||| |||| ||| . ..|. .|... .. .
lqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
subfamily_PTPN6_pd Subfamily PTPN6 641-906 1.4e-69 229.5 In-house 26-299 (306) alignment 
Range on Protein: 641-906
Range on HMM: 26-299/306.0
LKFKTQFQILESQTsgiDSVDSGESNSSSDENSQKNRYNNIGAIEATRIRL--NSPTGNDYINANYVD--SCNERNAYIATQAPLPSTFSDFWSMIWQER
  |. .|. |. .     .     ....  || .||||.||   . ||. |  .| .|.|||||||..  . .....|||||  |..| ||||.|.||| 
agfeeefeelqqee...akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

SNIIVCITNMVEDGKRKCDQYWPSQQDSPQtFGNYQVTLVSESTNAHFSHRILDLKIAkAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVH---Y-TS
|..|| .|. || || || .|||....... .|...|| |||...|..  | | ..        ||.|.|.||  |||||||..   .|.|..     ..
srvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskk.kkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

DIH--STGPVVVHCSAGVGRSGSYILVDSMRRHLISF---RRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRH
...  ..||.|||||||.|| |..|..| . . . .      ...|     .|.||  |||| .|| | ..||.. |..
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0037934 (Phosphotyrosine protein) phosphatases II 667-904 2.6e-69 228.8 In-house 5-242 (243) alignment 
Range on Protein: 667-904
Range on HMM: 5-242/243.0
SSSDENSQKNRYNNIGAIEATRIRLnspTGNDYINANYVDSCNeRnaYIATQAPLPSTFSD----FWSMIWQERSNIIVCITNMVEDGKRKCDQYWPsqq
... ||  |||| .| . . .|..|    |.||||||...  . |  .||||.|||.|. |    || |.|......||..|. || |. ||.||||   
allpenlsknrysdilpydhsrvkl...egsdyinanliyvtp.r..liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...

DSPqTFGNYQVTLVSESTNAHFSHRILDLKIaKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDI----------HSTGPVVVHCSAGVGRSG
..  |.|...|||.||.. ... .| | |.  .  . ..| |...|...|||||||.|. .||.|.... ..          .| |||.|||||||||.|
gev.tygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtG

SYILVDSMRRHLisfrRLNVQGHLTHMRRQRAK-LVQTLEQYIFCHEAIRQLI
 .|. . | ..|    .....  . ..|.||    |||..||.|..||...|.
tliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN13_pd Subfamily PTPN13 667-904 1.4e-66 219.5 In-house 32-269 (273) alignment 
Range on Protein: 667-904
Range on HMM: 32-269/273.0
SSSDENSQKNRYNNIGAIEATRIRLNSPTGndYINANYVDS--CNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDS
. ..|| .|||| |.  ...||..|.. .|  ||||...     ...  |||.| ||| | .||| |.|. ....|. .|. .|.|| ||..|||.....
gkkkenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknk

PQTFGN-YQVTLVSESTNAHFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS-TGPVVVHCSAGVGRSGSYILVDSMRR
. .  | ..|.|.       |. | | .|  ..  .  |.| .|.|. |||||||||  .|| || .   ... .||.|||||||.||||..| .| .  
klkvsnrlevellkvqkldgfvvralavkdses..gesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlg

HLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
 .   . ..|.  . ..|.||  .||| .||||...|| ...
lierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 669-903 1.4e-66 219.2 In-house 6-241 (250) alignment 
Range on Protein: 669-903
Range on HMM: 6-241/250.0
SDENSQKNRYNNIGAIEATRIRLNSPT---GNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRkCDQYWPSqqDSP
  .| .|||| .| |.. .|. |..       ||||| .... .||.|.||||.||..|. ||| |...| |. || .||..| .|  . ||||   . .
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..eka

QTFGNYQVTLVSESTNAHFSHRIldLKIAKAVPAVERKVHQLHFMGWPDHGVPS---SVFPLLSFVHYTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRR
...|. .|.| |. . | . .|   ||..||  | || | ||||. ||| |||    .|. ||. |. . .   ..||.|.|||||||||..| .|..  
ekyGdvtvsllskeefadytkrk..lklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

HLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
.|   . ..|   .  .|..| . |..||||.|..|.| . 
rlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_PTPN3_pd Subfamily PTPN3 667-904 3.7e-66 217.9 In-house 36-275 (280) alignment 
Range on Protein: 667-904
Range on HMM: 36-275/280.0
SSSDENSQKNRYNNIGAIEATRIRLNSPTGnDYINANYVD----SCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQ
.   || .|||| .| . .|||..|.. .  ||||||||.    | .  | ||||| ||..| .||| |.|...|..|| .|..||.|. || ||||...
arkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPete

DSpQTFGNYQVTLVSESTNAHFSHRilDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH--STGPVVVHCSAGVGRSGSYILVDSM
|. ...|...|.. .|...  .  |  .| . ..    |||..|| .. |||||||..   .|.||.   ...  .. |||||||||.||.| .||..  
de.leygefsvkcekedetksyvlr..elvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilleta

RRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
   . . . ...   . .|| ||| |||| .|| |  ||| .. 
lalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPRK_pd Subfamily PTPRK 635-912 6.1e-66 217.4 In-house 16-285 (314) alignment 
Range on Protein: 635-912
Range on HMM: 16-285/314.0
LNRNDSLKFKTQFqilESQTSGidsvdsgESNSSSDENSQKNRYNNIGAIEATRIRLNSPTGN---DYINANYVDSCNERNAYIATQAPLPSTFSDFWSM
|.|...  || ..   ||   |          .  ||| .|||...| | . .|..| .  |.   |||||...|| .  .|.|.|| ||..|  ||| .
lkraegygfkeey...eslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrl

IWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSpqtFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYT
...|..  || .|..|| |. || .||| . .    .|. .|.||. ...| . .||. .. ..      |.|.|..|.|||||.|| |   ||..|.  
vydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrv

S--DIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH
   . .. |..||||||| ||.| .| .|..   .   . ..|      .| ..  .|.| |||.|....| .    | | . 
kksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaip
subfamily_Ptp69D_pd Subfamily Ptp69D 633-912 3.4e-65 215.2 In-house 14-294 (307) alignment 
Range on Protein: 633-912
Range on HMM: 14-294/307.0
EDLNRNDSLKFKTQFQILESQtsgidSVDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTFSDFW
.  .|.    ..  .. ||..      .|   ..|  .||  ||||..| | . ||..|.  .|    |||||... . .|.. .|| |.|. .|  |||
ksrkrdtdfglakeyekLear.....eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfW

SMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqdSPQTFGNYQVTLVSESTNAHFSHRILDLKIAK-AVPAV--ERKVHQLHFMGWPDHGVPSSVFPLLS
 ||..  ...|| ..|. |  ..||..||| .    . .|.  |.||||..  .. .| ||.   |  .. |  .||| | |..||.|  || .   || 
RmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllk

FVHYTSDI--HSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH
...   ..  .. .|.|||||||||||| .. .||.  .|    ....     ..|.||  ||| ||||.|.. |. . . .| | . 
lieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtded
subfamily_PTPRA_pd Subfamily PTPRA 623-912 4.6e-64 211.4 In-house 14-303 (330) alignment 
Range on Protein: 623-912
Range on HMM: 14-303/330.0
IPVELFYGYVEDLNRNDSLKFKTQFQILESQTsgidsVDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQA
.||| .   ..    .|. .|. .|. | . .     ...    .| .|| .|||. ||   . .|. |.   |    ||||| ..|  .|.. .||.| 
lpvekleeeirirsaddnklfreefnalPagp.....iqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqG

PLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqdSPQTFGNYQVTLVSESTNAHFSHRILDLK-IAKAV-PAVERKVHQLHFMGWPDHGV
|.  |  ||| |||. .|  || .|.. |  . || ||||..     |.|| .|..  |    ... | . .. ...|     .| |.|.|| .||| ||
PkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGv

PSSVFPLLSFVHYT--SDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH
|.    .|....     .  |.||.||||||||||.|..| .|..   . . |...| . . ..| ||...|||.||| |.......   .| | ..
PfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld
subfamily_PTPN9_pd Subfamily PTPN9 667-900 6e-64 210.9 In-house 37-286 (297) alignment 
Range on Protein: 667-900
Range on HMM: 37-286/297.0
SSSDENSQKNRYNNIGAIEATRIRLNSPT---GNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQD
| .  |..||||...  .. ||. |..       ||||||.||  ....|.|||| ||. |.|||| |.|...  .|| .| .|| |..|| ||||....
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

SPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSD--------------IHST-GPVVVHCSAGV
| . ||...|. |.  .. .. .|.| .| .|     .|||    |..|||.|||||   || ...   .               | .  |.|||||||.
ssaefgdlsvsnveveeeedykvrvleiknvkt..eesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
||.| .| .|    .| .   ..|.  . ..| |||  .|| ||| ||. |.
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 622-926 7.1e-62 204.5 In-house 10-313 (319) alignment 
Range on Protein: 622-926
Range on HMM: 10-313/319.0
DIPVELFYGYVE-DLNRNDSLKFKTQFQILESQTSGIDSVDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIAT
|. |. |  |     |..|  . .|....   ... .    .  . .  |.|  |||. || | . ....|.   |    ||||| .|.    .. |||.
dvavpdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaa

QAPLPSTFSDFWSMIWQERSNIIVCITnmvedgKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNahfsHRILDLKIAK-AVPAVERKVHQLHFMGWPDHG
| ||. |  ||| |||. ..  || .|      | || |||| . .  .  .. .|..| |. .    . . |..... .     ||..| ||.||||.|
qGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae....yvvrdielsedgkekdirkitqfhflGwpdvG

VPSSVFPLLSFVHY----TSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVH
|| .  .|. .|.     ||  .   ..||||||||||.| || .| .   .   ....|   .  .|.|| .||| | || |.. |. .    | . | 
vpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva

SDLFMRYLHYLSEE
   |  ||. ||..
mpdfpayleelsnk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 669-939 1.4e-61 203.1 In-house 46-315 (315) alignment 
Range on Protein: 669-939
Range on HMM: 46-315/315.0
SDENSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqdsP
  || ||||| || | . .|..|   .   . ||.|||..|  | .. |||.|.|....  ||| ....|    || .||.||. |||...||| .    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...k

QTFGNYQVTLVSESTNAHFSHRILDLKIAKAVpaveRKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH--STGPVVVHCSAGVGRSGSYILVDSMRRH
 ..|.. ||..||  | ... | |     . .    |.| |||.  ||| ||| .  ||. ..      |  | |..||||||||||.|..| .|..  .
viyGkitvtrkseevnteytvrtlsvvfgdni....revvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldq

LISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFM-RYLHYLSEENLNGKTRMQLQFE
.   . ..|   .| .|..| |.||..||| | ..|. . .  | | .  ||.. ||   |.     | | .| |||
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeqfe
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 666-939 1.2e-60 200.0 In-house 38-313 (315) alignment 
Range on Protein: 666-939
Range on HMM: 38-313/315.0
NSSSDENSQKNRYNNIGAIEATRIRL----NSPTgNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQ
 .  ..| .||||.||  .. .|..|    .||  .||||| |. | .. .||||.|.||... .|||.|..||.   || .|.. |. | || |||| .
varetinfkknryknilPldsarvkleviddsPd.sdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

QDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpavERKVHQLHFMGWPDHGVPSSVFPLLSFVHY--TSDIHSTGPVVVHCSAGVGRSGSYILVDS
.     ||...|.|.| ....   .| | .. ...     |.| | .| .|||.||.  .  || ...   ... . . ...|||||||||.|  | .|.
kadsvefGsikvellsleadtdgvarklvtrksee....srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvviside

MRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFMRYLHYLS-EENLNGKTRMQLQFE
.  ..   | ..|   .. .|..| .|||| |.| | ..|... . .  | .    |  .|. |    . .|...|  .||
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefe
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 666-926 3.4e-60 199.0 In-house 19-277 (284) alignment 
Range on Protein: 666-926
Range on HMM: 19-277/284.0
NSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITnmvedgKRKCDQYWPSQQ
 .  |.|  |||. .| | . ....|.   |    ||||| ..     .. ||||| ||. |  ||| |||. ..  || .|      | || |||| . 
fanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplki

DSPQTFGNYQVTLVSESTNahfsHRILDLKIAK-AVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHY----TSDIHSTGPVVVHCSAGVGRSGSYILV
.  .  .. .|..|.|| .    . . |..... .     ||..| ||.||||.||| .  .|. .|.     ||  .   ..||||||||||.| || .
vikeerfkvkvdsveesee....yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFMRYLHYLSEE
| .   .   ....|   .  .|.|| .||| | || |.. |. .    | . |    |  ||. ||..
dvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 670-948 9.9e-60 197.1 In-house 41-322 (515) alignment 
Range on Protein: 670-948
Range on HMM: 41-322/515.0
DENSQKNRYNNIGAIEATRIRL----NSPtGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSP
. | .||||.||  .. .|..|    ..|  .||.|| |. | .  .||||.|.|.... .|||....||.   |. .|.. |. | || .||| .    
einfkknryknilPydsvrvklevindnP.hsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgds

QTFGNYQVTLVSESTNAHFSHRilDLKIAKAVPavERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTS--DIHSTGPVVVHCSAGVGRSGSYILVDSMRRH
  ||...| ||| .. .    |   |.. |      | | | || .|||.|||     || ...       . | |...|||||||| | .| .||.  |
vkfGsikvelvsleactggikr..kltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvah

LISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRH---GITRVHSDLFMRYLHylSEENLNGKTRMQLQFEDI-CDCKHQP
    | ..|   .| .|..| .|||| ||| | ..|... .      |  .|    .. ||  |  . .|...|  .|. . . |   |
akttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlh..ssgdgrgrskmtkefqtlkslcpdpp
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 632-932 1.6e-59 196.7 In-house 14-317 (325) alignment 
Range on Protein: 632-932
Range on HMM: 14-317/325.0
VEDLNRNDSLKFKTQFQILESQTSGIdsvdsgESNSSSDENSQKNRYNNIGAIEATRIRLNS---PTGNDYINANYVDSCNERNAYIATQAPLPSTFSDF
||  . .|   |  .|..| |. .           .   || .|||..|. |.. .|. |..    .  |||||.|. .  ... ..|.||||..|  |.
vekkkaqdqdgfahefgllpsddgia......kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindl

WSMI--WQerSNIIVcITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPS---SVFP
| ..  |.  . ..| ..|... || .| .||| .    .|||  .| |..  . . . ||.||.| .|      | |.|.....|.| ||.    .. .
WrlvldWr..csvvv.vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkk..GetrsvkqfqlqswddmGvqkrpatlis

LLSFVHYTSDI-----HSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLFMR
.|  |.  |.      ....|..|||||||||.| .| . |.  ..|   |... | . ..|..| ..|.| .|||...||. . .  | | |    |  
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfea

YLHYLSEEN-LNGKT
 |  | | | |  | 
klsslqernpltqkl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 623-900 9.7e-59 193.6 In-house 2-279 (290) alignment 
Range on Protein: 623-900
Range on HMM: 2-279/290.0
IPVELFYGYVEDLNRNDSLKFKTQFQILESQTSgIDSVDSGesnsSSDENSQKNRYNNIGAIEATRIRLNSPTGN-----DYINANYVDSCNERNAYIAT
|||. |  .|.  . .   .|..||. |.|  |   .|  |     . .|...||..||   .  || |.  .|.     .|||| |..  .|...||||
ipvdkfgefvanghakgnegfrnqfkmldsges.ehtvtvg....ltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiat

QAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqDSPQtFGNYQVTLVSESTNAHFSHRILDLKIAKAVpAVERKVHQLHFMGWPDHG-
|.|...|  |||..||||.. ||| .||..|.|| || ||||.. |. . .|.....|..|.|  .. .| |..|  ..  . ...|.|...  |...| 
qgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgk

VPSSVFPLLSFVHY--TSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
|.     ||.. .   |   .  ...|||||..||||. .. ..    .  .    .|   | ..| |. ..||| .|| . .. .
vtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_PTPN23_pd Subfamily PTPN23 638-906 1.1e-58 193.3 In-house 12-282 (288) alignment 
Range on Protein: 638-906
Range on HMM: 12-282/288.0
NDSLKFKTQFQILESQTSGIdsvDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSpTGNDYINANYVDSCNE-RNAYIATQAPLPSTFSDFWSMIWQER
..  .....|. ||..         . | . .  .|.|||...|   . .|. |.. . .||||| .| .       .|||||||.|| .|||.|.....
dgktaldkkfkeleqkqdke...arkrsiaiaklyseknrsrdilPyDhnRvklrg.skDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

SNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSD---
|..||....  | || |.|.|||.... ...||...||| |. .  ....|.| |.. .|     ..|  |... ||..|||.|   || |..   .   
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda..davksvshlqltsWpelGvPasPetllqfldevesaye

---IHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRR-LNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRH
    .|  |.||||||||||.| . || .  | |      |..   . ..|.||   ||. ||. |. ||. . .|.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPN1_pd Subfamily PTPN1 659-902 2.1e-58 192.3 In-house 19-269 (290) alignment 
Range on Protein: 659-902
Range on HMM: 19-269/290.0
SVDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSpTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYW
. |   ...  .|| ..||| ..   . .||.|.. . ||||||. |.  . .  || || |||.| . || |.|...|  .| . ..|| .. || |||
asdfptreaklpenrnlnryrdvspydhsrikler.adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSQQD-SPQTFG--NYQVTLVSESTNAHFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSD----IHSTGPVVVHCSAGVGRS
|.... .  ..   ...|.|.|| .. ..  |.|.|.  |.     |.. . |.. ||| |||.|   .|.|..   .     .  ||.|.|||||.|||
Pqgeeekellledtklkvkliseerksyytvrllelenlkt..qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrs

GSYILVDSMRRHLISFRR---LNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQ
|...|||..  ..        .... .| ..|..|  |.|| .|  | . || .
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 623-911 2e-57 189.4 In-house 2-285 (287) alignment 
Range on Protein: 623-911
Range on HMM: 2-285/287.0
IPVELFYGYVEDLNRNDSLKFKTQFQILESQTSGIDSVDSgesnSSSDENSQKNRYNNIGAIEATRIRLNsPTGNDYINANYVDSCNERNAYIATQAPLP
|||| |  .|.. ... .  ||.||..||. |   |.|      . . .| .|||...|   .  |. |.  . .||||| ..|. .|..|.|....|. 
ipvekfgefvakghakgnegfknqftvleqvtqredevth....niasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmf

STFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDspQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvPAVERKVHQLHFMGWPDHG-VPSSV
.|  .|| .|.... ..|| ...  |. ...| ||||...    ..|.|...|..| .||..  | |..|  .   . ...|.| ..  |...| |..  
ntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknk.agdkqqvkqyqitnWdstgkvtepq

FPLLSFV--HYTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRV
  || .     |   .. ...|||||..||||. .. ..   ..      ..|   | ..| |. . ||| |||.|  ... . .  . |..
tillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetys
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 671-903 2.3e-55 182.6 In-house 27-267 (274) alignment 
Range on Protein: 671-903
Range on HMM: 27-267/274.0
ENSQKNRYNNIGAIEATRIRLNSPTG--N--DYINANYVDSCN-ERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDS-
 ...||||..|   | .|. |.| ..  .  .||||||.   . | .||.||| |||.| .||| ||.||....|| .|.. |  ..|| .|.| ..|  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

-PQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpavERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDI-----HSTGPVVVHCSAGVGRSGSYILVD
  ...|. ... ..  .. ..| | | || ..     ||.|.   .  |||| .| .. .||..|. ...      . ..|||||||||.|| | .| ..
iserygdveikvekiverndysvrklvlkyler....ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

SMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
   |.|     ..| .  ...| .|  .||| ||| . |.|. . 
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_PTPN14_pd Subfamily PTPN14 662-905 5.8e-55 181.4 In-house 39-297 (300) alignment 
Range on Protein: 662-905
Range on HMM: 39-297/300.0
SGESNSSSDENSQKNRYNNIGAIEATRIRLNSP--TGNDYINANYVDS--CNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQY
.  | .. .|| .|||....   | .|..|..   . ..||||  .    . ..  ||..|.||. |  ||| |.|..  ..|| .|.  |||| |. .|
allstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfky

WPSQ--QDSPQTFGNYQVTLVSESTNAHFSHRilDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHY--------TSDI---HSTGPVVVHC
.|..  . .  .||...||    ..   .  .   ||.       ||.|. | .. |||||||. | . ||...         .| .   .|  ||.|||
fPkleskkktvefgkfkvttkfsedsdsvitt..glklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhC

SAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIR
||||||.|  ||.| .   |   ......  |...|.||  ||||| || | .... . ..
saGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 671-905 1.2e-54 180.2 In-house 19-265 (270) alignment 
Range on Protein: 671-905
Range on HMM: 19-265/270.0
ENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVD-SCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQ
 ... |||..|    |||.||.. .      |||||||    .|...|||...|||.| ..|| |||.|... || .|...|.|..||..|||.....  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

TFGNYQVTLVSESTNAHFSHRILDLKIAkaVPAVERKVHQLHFMGWPDHGVPSS---------VFPLLSFVHYTSDIHST-GPVVVHCSAGVGRSGSYIL
.. . ... ...|.. .  ...  |..     . ||..   ..  |||||||..         .  .|  |. ... ..  .|..|||||||||.|  |.
kledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

VDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIR
.| . | | . ....|   ....|..| .|||. ||| | ..|... ..
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 671-913 1.1e-53 177.4 In-house 50-293 (297) alignment 
Range on Protein: 671-913
Range on HMM: 50-293/297.0
ENSQKNRYNNIGAIEATRIRLNSPTGN---DYINANYVDSCNErnAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKrKCDQYWPSQqdSPQT
 | .|.||.||  ..  |..|..   .   ||.|| .| . ..   .|.|| | ..|  ||| |...|. ..|| ...  |  | || .||. .  . .|
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk..gvtt

FGNYQVTLVSESTNAHFSHRILDlkIAKAVPAVERKVHQLHFMGWPDHGVPS--SVFPLLSFVHYTSDIHS---TGPVVVHCSAGVGRSGSYILVDSMRR
||.  |.| | |    |..| |.  ..|  . ..| |.| .|. |||. |.   |.  || ...   . .|    ||..|||.||||| | .. .||.  
fGdvsvvllsvsereGfikrele..vtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvva

HLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHS
.      ... | ....|..| .|||| ||| | ..|. . .    ||...
eakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqa
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 671-900 2.3e-52 172.6 In-house 2-235 (237) alignment 
Range on Protein: 671-900
Range on HMM: 2-235/237.0
ENSQKNRYNNIGAIEATRIRLNSPTG-NDYINANYVDSCNE-RNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqDSPQTF
||  |||| || | . .|. |. . .  |||||.|... .   . |||.| || |.  ||| |.|||.  .|| .| ..|  . || .||||  | |...
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaay

GNYQVTLVSESTNAHFSHRILDLKIAKAVPAVeRKVHQLHFMGWPDHGVPSSVFPLLSFVH----YTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHL
| . |.|  .   . .. | | |     .  | | .|| .|  |||.|||     || | .     .  .  .|| ..||||||||.| ....|.| |. 
gvltvslkkkeefsdytvrslllskrltlkev.rlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

ISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
   . ...  ..  .  .|  ..|| .||.| |..|
kekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 671-901 6.6e-52 171.1 In-house 37-274 (287) alignment 
Range on Protein: 671-901
Range on HMM: 37-274/287.0
ENSQKNRYNNIGAIEATRIRLN--SPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQqDSPQTF
 . .|||| ..  |. ||. |   .  | |||||||| | .. .|.||.|.|...|  ||| .....||  .. .|  ||... || .||| . . |   
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GNYQVTLVSEStNAHFSHRILDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHY-------TSDIHSTGPVVVHCSAGVGRSGSYILVDSMR
| | |.|.. . . .  . .  |.....     | |.||... |||.... .   |. ||         . |   .||.|||...|.|||| .. .  . 
GGysvvlldyd.ikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

RHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIR
. | .  |..|   . ..| .|| |||.  |. .  ||. 
srledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 628-916 2e-51 169.8 In-house 7-291 (439) alignment 
Range on Protein: 628-916
Range on HMM: 7-291/439.0
FYGYVEDLNRNDSLKFKTQFQILESQTSGIDSVDSgesNSSSDENSQKNRYNNIGAIEATRIRLNSPT---GNDYINANYVDSCNERNAYIATQAPLPST
|  .||.|..|.   ||  |. ..|       . |     . . .  ||||...|| . ||. |.         ||||||..   . . |||||.|   |
fqehvekldknkqeifkeifekinstspdyacias...laaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkket

FSDFWSMIWQERSNIIVCITNMVEDGKrkcdqYWPSQQDSpqTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPL
  ||| .......  || .||.||  |     ||||...    .|.  |    .    ..  | . .   .     || | |.|.. |||. ||.    .
tddfwrlviekktvtivmltnlvesyk.....ywpsdaev..cygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashv

LSF---VHYTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLF
| |   .  . | . .|||||||||||||.|. | .|    .| .  .....| .. .|.|| ..||.| ||.| ..|. . | .| . |  | |
ldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidef
subfamily_PTPRN_pd Subfamily PTPRN 642-904 3.5e-51 168.7 In-house 30-292 (297) alignment 
Range on Protein: 642-904
Range on HMM: 30-292/297.0
KFKTQFQILESQTSGidsvDSGESNSSSDENSQKNRYNNIGAIEATRIRLN---SPTGNDYINANYVDSCNER-NAYIATQAPLPSTFSDFWSMIWQERS
... ... | .  .     .| .. .....| .|||.... . . .|..|.   | . .|||||  .   . |  ||||||.||.|| .||| |.|.. .
rlekewealcayeae....pstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

NIIVCITNMVEDGKRKCDQYWPSQqdSPQTFGNYQVTLVSESTNA-HFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIH-
 .|| .|.. |.| ..|..||| .    .... |.| ||||   .  .  | . ||  ..     | | |.||. ||..|||.|  .|| |       . 
vvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvrsfylknlqt..setrtvtqfhflswpeegvPasaksllefrrkvnksyr

-STGPVVVHCSAGVGRSGSYILVDSMRRHL-ISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
  . |.|||||.|.||.| |||.| .  .|    .....   | |.| ||..||.| .|. |.  |. . .
GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeev
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 640-904 2.4e-50 166.0 In-house 14-293 (301) alignment 
Range on Protein: 640-904
Range on HMM: 14-293/301.0
SLKFKTQFQILESQTSGIDSVdsgesnSSSDENSQKNRYNNIGAIEATRIRLNSP-----TGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQ
| ||. |.. |.....   .|      . |.||.. ||..||  ..  || |.       . ..||||.|.|...|....||.|.|. .|  ||| .|||
snkfeeqykelkegedksctv......glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

ERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVP--AVER-----------KVHQLHFMGWPDHGV---P
|.   || .||. |. | || ||||. . . ..||. .||||.| .   |  | | .|| ..     .||           .| ||.   ||..||   |
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrep

SSVFPLLSFVHYTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
  |   .  | ..    . ||||||||..|.||| |. |.       .    .| .    .||.. . |.|||||.. ...| . .
rtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 647-906 1.1e-49 163.8 In-house 8-269 (283) alignment 
Range on Protein: 647-906
Range on HMM: 8-269/283.0
FQILESQTSGIDSVDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSPTgNDYINANYVD---SCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCI
...   .   .   |     .|.||| .|||...| . .  |..|.| . .||||| ..    | .. . ||..|.||  |  ||| |...|.   || .
nklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelkses.rdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

TNMVEDGKRKCDQYWPSQqdSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPA-VErkVHQLHFMGWPDHGVPSSVFPLLSF--VHYTSDIHSTGPV
|.. || . || ||||..    . .|.. |||  | |.  |. . | |.   .  . .   .    . .| . |  . .  |. |  |      .  ||.
tklqedlrikCsqyWPkr..GsedyGeftvtlrkettsnsfiikelllrvnssakstll..lahyqvidWleygeqaiinslvkfnkvislqteskkgPi

VVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI-RQLIRH
|||||.|.||.. .| . .   .. .   ..|   .. || ||  .||||.|| . ||..  | .  
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcg
0041856 (Phosphotyrosine protein) phosphatases II 672-910 1.3e-48 160.3 In-house 1-177 (182) alignment 
Range on Protein: 672-910
Range on HMM: 1-177/182.0
NSQKNRYNNIGAIEATRirlnsptGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITnmvedgkrkCDQYWPsqqdspqtfgny
|  |||| .|  .. .|       ..||||||.....   . .||||.||.||. ||. |..... ..||..|         ...|||            
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

qvtlvsesT-NahfshrildlkiakavpavERKVHQLHFMGWPDHGVPSsVFPLLSFVHYTSDihSTGPVVVHCSAGVGRSGSYILVDSMRRHlisfrRL
        .                     || ..|.....|||||||. .  ||.|..   .  . |||.|||||||||.|.... . |...     ..
........ell...................erlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gv

NVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITR
...  . ..|..| . |.|..||.|.. |...|.....||
sleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 671-904 1.3e-47 157.1 In-house 47-287 (305) alignment 
Range on Protein: 671-904
Range on HMM: 47-287/305.0
ENSQKNRYNNIGAIEATRIRLNSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFG-
....|||| ..| ..  |..|..|   .|| |||| .  . . .| |||||  | .||| | .|.. . |  . |..| | .|| .|..|...   .|  
qeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefee

-NYQVTLVSESTNAHFSHRILDLKIAKAVPAVE------RKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSdiHSTGPVVVHCSAGVGRSGSYILVDSMRR
 . ....  ||...   ..  . |. ..|  .|      ||| . |.. ||| |||..   .| ... .    | ||.|||||||.||.|| .... .  
kgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar..pskgpivvhcsagigrtgsvvmleyild

HLISFRRLNV-QGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
 |.. . ..  .  | ..| || . .|| .||.| |. | . .
qllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 672-900 1.4e-46 153.6 In-house 7-236 (239) alignment 
Range on Protein: 672-900
Range on HMM: 7-236/239.0
NSQKNRYNNIGAIEATRIRLN---SPTGNDYINANYVDS-CNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPsqqDSPQT
|  |||| || . . .|. |.       .|||||.|.       .||||||  .  .  ||| |.||||  .|| .| ..|  |.|| ||||   ||   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

FGNYQVTLVSESTNAHFSHRIldLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVH-YTSD-IHSTGPVVVHCSAGVGRSGSYILVDSMRRHLI
. | .|||      | .  |   . ...   . || |.| ||  |||.|||     .| . .  | | .  . | |.||||||||.|.....|.| |.  
ycnlrvtlrktevfadyiirt..fvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

SFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
  . ...  ..  .| .| ..||| |||.| | |.
kqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 672-900 1.5e-46 153.5 In-house 8-237 (239) alignment 
Range on Protein: 672-900
Range on HMM: 8-237/239.0
NSQKNRYNNIGAIEATRIRLN---SPTGNDYINANYVDS-CNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPsqqDSPQT
|  |||| || . . .|. |.       .|||||.|.       .||||||  .  .  ||| |.||||  .|| .| ..|  |.|| ||||   ||   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

FGNYQVTLVSESTNAHFSHRIldLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVH-YTSD-IHSTGPVVVHCSAGVGRSGSYILVDSMRRHLI
. | .|||      | .  |   . ...   . || |.| ||  |||.|||     .| . .  | | .  . | |.||||||||.|.....|.| |.  
ycnlrvtlrktevfadyiirt..fvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

SFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
  . ...  ..  .| .| ..||| |||.| | |.
kqktvdifnyvkairedrphmvqtseqyvfihlav
0051429 (Phosphotyrosine protein) phosphatases II 697-925 5.4e-46 152.7 In-house 4-245 (272) alignment 
Range on Protein: 697-925
Range on HMM: 4-245/272.0
NDYINANYVDSCNE---RNAYIATQAPLPSTFSDFWSMiWQERSNIIVCITNMVEDGKRKCDQYWP----------SQQDSPQTFGNYQVTLVSESTNAH
..||||..|.  .    .........||| |  ||| . .... . ||.... .| |. |||.|||          .  . . ..|.. |||.||..  .
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

FSHRILDLKIAKAVPAVeRKVHQLHFMGWPDHGVPSSVfpLLSFVHYTSDihsTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLN--------VQGH
. .| | |..     .. |.|..||...|||||||..   ||.....  |    |||.||||||..|.| ..... . . .     ..        ... 
yilrellltlllsagea.revmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleea

LTHMRRQRAKLVQTLEQYIFCHEAIRQLiRHGITRVHSDLFMRYLHYLSE
. ..|.||.. ||| |||.|..||...|   ... |. . ....|... |
veelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaide
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 670-901 8.3e-45 147.7 In-house 52-280 (290) alignment 
Range on Protein: 670-901
Range on HMM: 52-280/290.0
DENS--QKNRYNNIGAIEATRIRLNSPTGNDYINANYVDSCNerNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQT
|.|.  .|||| ..   . ||. |.     ||. ||||.  .    .| || .| .|  |.| |. ||.   || . ...|||| ||.||.| ..    |
dkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

FGNYQVTLVSES-TNAHFSHRILDLKIAKavPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSdiHSTGPVVVHCSAGVGRSGSYILVDSMRRHLIS
||.. |.   |.  .|.  ...| ..  .     | |.. |. . |||. |. | . ||  ..     . .||||||||||.||.|... ..   . |. 
fGeitvlcseeddkdaniikktlsvrdkd..sGkehklkhlkikswpdksvalstlallrtlrilr..kasGpvvvhcsaGiGrtGtfvaievglqilld

FRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIR
 . |.. .    .|. |.. ||   ||.   |.. 
Gkeldlldlvralrnsrlnsvqvdiqylalveill
subfamily_CG7180_pd Subfamily CG7180 642-906 1.9e-44 146.5 In-house 14-292 (296) alignment 
Range on Protein: 642-906
Range on HMM: 14-292/296.0
KFKTQFQILESQTSGIDSVDSGEsnSSSDENSQKNRYNNIGAIEATRIRLNSPTGN---DYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSN
||. ... .  .|. ... |         || .|||. ..   . .|. |..  |.   ||||| ||||    ..|| |.||  .|  .||.....| ..
kfrveyklelkltprleigdCag..glrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeis

IIVCITNMVEDGKrKCDQYWPSQQdsPQTFGNYQVTLVSESTNAHFSHRILDLKIA--------KAVPAVERKVHQLHFMGWPD-HGVPSSVFPLLSFVH
 .| .|.  .  | .. .||| ..   . .|.  | .|.| . |..  | . |.          | | | .| |.....  |.  . ||.|   |. ...
avvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

Y----TS---DIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRH
          .   .|||||..| |..||| |. .|     ..   ...| . .  .||.| .||.. |.| .. . . . . .
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 622-936 4.3e-44 145.5 In-house 3-269 (392) alignment 
Range on Protein: 622-936
Range on HMM: 3-269/392.0
DIPVELFYGYVEDlNRNDSLkFKTQFQILESQtsgiDSvdSGESNSSSDENSQKNRYNNIGAIEATRIRL---NSPTGNDYINANYVDSCNERNAYIATQ
 |||  |  .||. ||  .| |  .|. | .     |   . .. .  . | .||||.||  ....|..|   .  . .||.|| |..| .  .||||.|
pipvaqfpafvek.nrhsal.ffeefhdlpgp....di..ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasq

APLPSTFSDFWSMIWQERSNIIVCITNMVEDGkrkcdqywpsqqdspqtfgnyqvtlvsestnahfshrildlkiakaVPAVERKVHQLHFMGWPDHGVP
.| .....|||.|..||.   |. .|.. |                                                     | | | ||  |||..||
gpnaaslddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhftewPdkdvp

SSVFPLLSFVHYTSDIHS--TGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHSDLF
  .  || |..  .  .   | |...||||||||.|  | .||.  |    | ..|   .| .||.|  .||| ||| | . |. . . .  | .    |
khtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhf

MRYLHYLSE-ENLNGKTRMQL
  .|. ||   . ....... 
tdhlqdlstssdGdvrskqlk
0036282 (Phosphotyrosine protein) phosphatases II 696-898 4e-43 142.5 In-house 1-164 (174) alignment 
Range on Protein: 696-898
Range on HMM: 1-164/174.0
GNDYINANYVDSCNERNAYIATQAPLPstfsdFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSqqdspqtfgnyqvtlvsestnahfshrildlkiak
|.|||||...|     . .||.|.||.     || |.........|. .. .|.|. || .|||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

AVPAVERKVHQLHFMGWPDHGVPSSVFpLLSFVHYTSDIHST---GPVVVHCSAGVGRSGSYILVDSMRRHLIsFRRLNVQGHLTHMRRQRAKLVQTLEQ
     || ..|.....|||||||..   ||.|| .  ...|    |||.|||||||||.|  .. . | |.|.  .  ..  ..  .|.|| . ||| .|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YIFCHE
|.|...
yrflyy
0043147 (Phosphotyrosine protein) phosphatases II 696-899 1.2e-40 134.4 In-house 4-156 (172) alignment 
Range on Protein: 696-899
Range on HMM: 4-156/172.0
GNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMvedgkrkcdqywpsqqdspqtfgnyqvtlvsestnahfshrildlkiAK
|.|||||.|.| .   . .||||.||..|..||| |....  ..||..|.                                                 .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................ly

AVPAVERKVHQLHFMGWPDHGVPsSVFPLLSFVHYTSD---IHSTGPVVVHCSAGVGRSGSYILVDSMRrhlisfRRLNVQGHLTHMRRQRAKLVQTLEQ
  . .|| . |.....||||||| .   ||.|...  .   . . |||.|||||||||.|  .. . |.      ..|...  . ..|..| . ||. .|
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YIFCHEA
|.|... 
yrflyyf
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 667-900 1.9e-40 133.8 In-house 36-273 (307) alignment 
Range on Protein: 667-900
Range on HMM: 36-273/307.0
SSSDENSQKNRYNNIGAIEATRIRLNSPT-GNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSP
 . . |..||||... ... .|| .. .    ||| |||.  . . . .|..| || .|  .||.|. ||. . .. . ...| .| ||.|||| ..   
eafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqk

QTFGNYQVTLVSESTNA-HF--SHRILDLKIAKAVP-AVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSdiHSTGPVVVHCSAGVGRSGSYILVDSMR
..||.   |.  .   | ..   . ....   | .     | ...| .  |||.|||   .  . ... .     | ||||||||||||||. . .  ..
lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr..ydtnpvvvhcsaGvGrsGtivaislvq

RHLISFRR-LNVQGHLTHMRRQRAKLVQTLEQYIFCHEAI
  .|.     ...  .  .| ||   .||  ||.. |  .
dkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvl
0046846 (Phosphotyrosine protein) phosphatases II 694-904 1.9e-40 133.8 In-house 9-173 (176) alignment 
Range on Protein: 694-904
Range on HMM: 9-173/176.0
PTGNDYINANYVDSCnernAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQtfgnyqvtlvsestnahfshrildlki
. . ||||||.....    ..||||.|||.|. ||. |..... ...|..|..|| |. ||..|||  ..                              
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

akavpaverkvhQLHFMGWPDHGVPSSvFPLLSFVHYTSDIHSTG-PVVVHCSAGVGRSGSYILVDsmrrhLISF-RRLNVQGHLTHMRRQRA-KLVQTL
            | ....|||||||..   ||... .  .  . | ||.||||||.||.| ... .     |.   . |.|.  | ..|.||  . ||| 
............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavqtp

EQYIFCHEAIRQLI
||| |..|....|.
eQyrflyefellll
0049260 (Phosphotyrosine protein) phosphatases II 704-898 4.6e-40 132.1 In-house 1-144 (152) alignment 
Range on Protein: 704-898
Range on HMM: 1-144/152.0
YVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWpsqqdspqtfgnyqvtlvsestnahfshrildlkiakavpaverk
..| ..  ...||||.|.| |..||| |...   ..||..|. .|.|| ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

vhQLHFMGWPDHGVPSSVFPLLSFVHYTSD--IHSTGPVVVHCSAGVGRSGSYILVDSMRrhlisfRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHE
  | ... |||||||.. . || ...      ... |||.|||||||||.| ... . |.      ......  . ..|..| . |.. .|..|..|
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
0049772 (Phosphotyrosine protein) phosphatases II 667-907 9.5e-40 132.6 In-house 41-283 (314) alignment 
Range on Protein: 667-907
Range on HMM: 41-283/314.0
SSSDENSQKNRYNNIGAIEaTRIRLNSPT--GNDYINANYVDSCnerNAYIATQAPLPSTFSDF----------WSMI--WQERSNIIVC----------
..  .|  |||| .|   . .| .|..    | |||||.|||..   ...||||.||. |. ||          |.|.  .. .. .||.          
adlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------ITNMVEDGkrkcdqywpsQQDSPQTFGNYQvtlvsestnahfshrildlKIAKAVPAVERKVHQLHFMGWPDHGVPsSVFPLLSFVHYT
           .... . |           . ..... ...                   ..    . .|| . ... . .||...| .   ...|... 
srLdaAlgKtpllildgng..........neptaadlellk...................eelydpelferlgikylripvpDgsap.lledfdeflefi

SDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLisfrRLNVQGHLTHMRRQRA-----KLVQTLEQYIFCHEAIRQLIRHG
 . .  |||.|||.||.||.|...... . ..|    .....  | ..|..|       ....||||.|..||......  
eeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 650-827 9.3e-39 128.0 In-house 9-189 (297) alignment 
Range on Protein: 650-827
Range on HMM: 9-189/297.0
LESQTSGIDSVDSGESNSSSDENSQ--KNRYNNIGAIEATRIRLN-SPTGNDYINANYVDSCNERN--AYIATQAPLPSTFSDFWSMIWQERSNIIVCIT
||..   .     ||| ||.  ||   ||||..| | . ||..|  ..|..|||||.||   .| .   || .| || .|  ||| .....  ..|| ..
leaekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva

NMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpAVERKVHQLHFMGWPDHGVPSSVFPLLSF
.. |||. ||  |||| ..  .. |.. |  .|. .. .    . .|..     . .|.|.   |..|||||||| .  |  |
klqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 671-906 1.6e-38 127.4 In-house 42-273 (288) alignment 
Range on Protein: 671-906
Range on HMM: 42-273/288.0
ENSQKNRYNNIGAIEATRIRLNsPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGN
.|. ..||.|.   ..||..|.    . ||.|| | | . ..  | .|||| .|   .| |. ..  . || .....| ||.| ..|.||..     .| 
anptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

YqVTLVSESTnaHFSHRILDLKIAKAVPAVERKV--HQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHstGPVVVHCSAGVGRSGSYILVDSMRRHLISFR
.  | | ..      .... . . .    .| ||   .||.  |.|.||| .  . | ...   ...   |.|||.||||||.|  ||.  . . | .  
l.ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq..kPivvhssaGvGrtgtlililialeslrldd

RLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRH
 | ..  |...| .| | .||  ||.. |  . . .  
flgirsllaklreerfkaiqtemqylyvhrcvleelll
subfamily_ptpA1_pd Subfamily ptpA1 642-864 1.2e-37 124.6 In-house 22-256 (418) alignment 
Range on Protein: 642-864
Range on HMM: 22-256/418.0
KFKTQFQILESQTSgidsvDSGESNSSSDENSQKNRYNNIGAIEATRIRLN---SPTGNDYINANYVDSCNERnAYIATQAPLPSTFSDFWSMIWQERSN
| | .|..||          |  |.     |. |||| ||  .. ||..|.      |.|||||||.| .  .  .|.|| ||| | .||| |.|..|  
kikeefrlleesvg.....psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcr

IIVCITNMVEDGKRKCDQYWPSQQDSP---------QTFGNYQVTLVSESTNAhfSHRILDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVH
||| ..   |. . |||.||| |             . || | | ||    .    . |.  .|  ..    | . | .. ||||| .|    |.  ..|
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdp..ereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllh

YTSD-----IHS---TGPVVVHCSAGVGRSGSYILVDSMRRHL
  ..     | |     |..|||||||||.|..     | ..|
sitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 642-901 1.2e-36 121.1 In-house 7-256 (267) alignment 
Range on Protein: 642-901
Range on HMM: 7-256/267.0
KFKTQFQILESqtsgIDSVDSGESNSSSDENSQKNRYNNIGAIEATRIRLNSpTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIV
... .|. ..     | .  |  | | . .| ..||...    . ||. |   . ..|||| ||.. . .||.|.|| ||  | .||. .| ...  .||
eiekefelikk....isdtsstisqsiaeknqernrlddnlpyddtrvilrt.keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

CITNMVEDgkrKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvPAveRKVHQLHFMGWPDHGV-PSSVFPLLSFVHYTSDIHSTGPV
 .|.  .|   .  ..|| .    . . .  |    |  .  .    |.||. .   |  ..|   ..  |         . ||.  .          |.
lltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkne.sa..hnvtlyyykkwnintnnkpylkplfgilaknqlengnrPl

VVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIR
||.||.||||||... .||. . .     ...   | ..| ||  ||.|.|.||..|| . 
vvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 663-900 1.8e-36 120.3 In-house 46-285 (305) alignment 
Range on Protein: 663-900
Range on HMM: 46-285/305.0
GESNSSSDENSQKNRYNNIGAIEATRIRLNSPTGNDYINANYVDSCN-ERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQ
 ..| |.| .  ||||... . . . ..|. |.  ||| ||||       . .|..| ||  |  .|| |. |.. . || . . || || || ||||  
fnanqsadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

QDSPQTFG-NYQVTLVSESTNAHFSHRI--LDLKIAKAvPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVhyTSDIHSTGPVVVHCSAGVGRSGSYILVD
|   ...     |  || |   .    |    |... .    .  | .|..  ||| |||   .  | ..  ..   |  |.|||||||.||.|. . ..
qgeklelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslell..sairgskvpivvhcsagigrtgtivaie

SMRRHLISFRRLNVQGHLT-HMRRQRAKLVQTLEQYIFCHEAI
 .  ..   ..     .|   .| |||  .|.  ||.| |  .
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvm
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 671-898 6.1e-35 115.2 In-house 36-263 (281) alignment 
Range on Protein: 671-898
Range on HMM: 36-263/281.0
ENSQKNRYNNIGAIEATRIRLNS--PT--GNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQ
 | .|||| || ... .|..|.   |     ||| |||. |   .  || || |   | .||| ||||| .  || . ...|  . || .|.| .     
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

TFGNYQVTLVSESTNAHFSHRILDLKIakavPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTsDIHSTGPvVVHCSAGVGRSGSYILVDSMRRHLIS
 | .. |.    . |  .    |.|          | . .  .  |||  || |   .|  ..     .|| | |.||||||||||. . |.   . . |
qfdklsvsyedstvnkslvttrlnlsy....egetrlithwlwkewpdwqvpessevmlkilrki.rarstpp.vihcsagvgrsgtlmaveialqsihs

-FRRLNVQGHLTHMRR-QRAKLVQTLEQYIFCHE
 |   ...  ..|.|   ||  ||||.||..  .
hftlpdikqivshlrvtgraasvqtlqqymliwk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 667-903 6.2e-35 115.2 In-house 47-289 (310) alignment 
Range on Protein: 667-903
Range on HMM: 47-289/310.0
SSSDENSQKNRYNNIGAIEATRIRLNS--PTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQdS
 .  .. .|||| ..   ...|..|.      .||| |||| .   |...| .| ||  |  ||| ||.|||.. |. . ...|.|. ||  ||||    
eaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.v

PQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVER-------KVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHstGPVVVHCSAGVGRSGSYILV
 .|.|  .|| .|||..      .    .   ||  |.       .|  ...  ||| |||      .     .   |  ||.|||||||..| .  . .
tetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvval

DSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
.    .|    .....   |.....||. .||  ||.. .     .
klkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 667-895 9.9e-34 111.4 In-house 45-272 (301) alignment 
Range on Protein: 667-895
Range on HMM: 45-272/301.0
SSSDENSQKNRYNNIGAIEATRIRLNSPTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQ
| .  . .|.||...     | ... .      | ||....  . . .||||.||..|  ||| |. |   . || ... ||. ..||..| |..  .  
syaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

TFGNYQVTLVSEST--NAHFSHRILDLKIAKAvPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSdiHSTGPVVVHCSAGVGRSGSYILVDSMRRHL
  | ........ .  | . |.| |... .       | |    .. |.|.||| |   |  ...     .|  |.|||||||.||| ..|  . . |..
digrfkikiknkelilnkkiskrtlevedstg.kfatrtvthyqysewtdrgvPkshaelfdlmelvk..ksekPivvhcsaGiGrsvafigteylarev

ISFRRLNVQGHLTHMRRQRAKLVQTLEQYIF
 . ......  | |.| .| . ||| .|  .
eadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 675-903 1.7e-33 110.7 In-house 46-275 (312) alignment 
Range on Protein: 675-903
Range on HMM: 46-275/312.0
KNRYNNIGAIEATRIRLNSpTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQ-----QDSPQTFG
 ||| ||   .  |. |     | || ||.|  |   . ...||.|| .| . || .     |  |. .. .||||  || .|          .  . . 
lnrypniqcwdrgrftlag.denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

NYQVTL-VSESTNAHFSHRILDLkIAKAVpAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSdiHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFR
.|   . .   .. . .||.| . . ||    | |. .  .  |||||.| |.   | ..      .   ||. ||||||||.|. .|..||   |   |
eycteieiggkskdkithrvlkv.vvkat.gqesklnhyqwaswpdhgmpdscdtalrllsavk..kdkkpviahcsagvgrtgtlaliesmiaalrhpr

RLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
. ||.  .  .|..||. |... ||...  .. ..
kqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef
0051082 (Phosphotyrosine protein) phosphatases II 697-899 5.3e-33 109.1 In-house 3-148 (151) alignment 
Range on Protein: 697-899
Range on HMM: 3-148/151.0
NDYINANYVDSCnernaYIATQAPLPstfsDFWSMIWQERSNIIVCITNMVEDGkrKCDQYWPSQQdspqtfgnyqvtlvsestnahfshrildlkiaka
.||||..||..      ......||.    ||. .....  . ||.... .| |  .| .|.|...                                  
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

vpaveRKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDiHSTGPVVVHCSAGVGRSGSYILVDSMRRHlisfrrLNVQGHLTHMRRQRAKLVQTLEQYIFC
     ..|.......|||.|.| |   .|.|...  | .. |||.||||||.||.|  .... | ..      ....  | ..|..|  .||. .|..|.
.....ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HEA
. |
lfa
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 668-899 5.7e-33 109.1 In-house 31-265 (285) alignment 
Range on Protein: 668-899
Range on HMM: 31-265/285.0
SSDENSQKNRYNNIGAIEATRIRLNSpTGNDYINANYVDS-CNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQ
. . | . ||| .. .|| ||. |.     ||| |...    .....||.|| ||| |.|||| ||.||.   .. .  ..| |  ||  |.| .     
ayeanpdlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

TFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLH--FMGWPDHGVPSSVFPLLSFVHYTSDIHS-TGPVVVHCSAGVGRSGSYILVDSMRRH
 ||.|..||     .|     .  | . ..  |    ..  |     |||.  |    |.. . ..   .     |..|||||||||. ... .|    .
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatir

LISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEA
..    ...   .  ||  | . ||.  |..| .  
imenpniemldivremramrfqavqshmqflflyvv
subfamily_egg_pd Subfamily egg 665-923 2.5e-32 106.8 In-house 33-288 (307) alignment 
Range on Protein: 665-923
Range on HMM: 33-288/307.0
SNSSSDENSQKNRYNNIGAIEATRIRLNSPTG---NDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDgkRKCDQYWPSQ
 .. ||.| .| | . .   . .|..|. . |   .|.| ||.|.     | .| .||||  |  ||| |..||. . || .|  .|    .|. |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

QDSPQTF--GNYQVTLVSESTNAHFSHRILDLKIakaVPAVERKVHQLHFMGwpDHGVPSSVFPLLSFVHYTSDIhsTGPVVVHCSAGVGRSGSYILVDS
.. .  .  |..... .    .|    |.  ||.   | . . . .  |. |  |    | |.  |  .    ..  . ||||..  || .... . .. 
esdslvtvpGslrienlkvdskadplfrvtklkl...vGgddeerflehwqg..dvnnssdvysplrvlrklrnl..skpvvvqdilGvskaatlvaiei

MRRHLIS--FRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITRVHsDLFMRYLHYL
   .|.     .  |.     .|..|   |..  .|.| .  .  ..|  |  .. .| . |  .|
allsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsak.eldvdyerwl
0044763 (Phosphotyrosine protein) phosphatases II 694-904 9.7e-32 105.4 In-house 15-171 (178) alignment 
Range on Protein: 694-904
Range on HMM: 15-171/178.0
PTGNDYINANYVDSCnernAYIATQAPlpstfSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDspqtfgnyqvtlvsestnahfshrildlki
. . |||||....       |.... |     .|.. .....  . ||..|. .| |. |||.|||.. .                              
lersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............................

akavpaverkvHQLHFMGWPDHGVPSSVFPLLSFVHYTSDI--HSTGPVVVHCSAGVGRSGSYILVDSMRRHlisfrRLNVQGHLTHMRRQRAkLVQTLE
            | .....||||||..   .| ||..  ..   . |||.|||||||||||. .. . |...     .|...  . ..|..|   |.. .
...........iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpg

QYIFCHEAIRQLI
|. ...|  ..| 
qlrqLyefelrll
PTPc_DSPc_SM00012 803-901 1.9e-29 97.3 In-house 1-104 (105) alignment 
Range on Protein: 803-901
Range on HMM: 1-104/105.0
KVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS----TGPVVVHCSAGVGRSGSYILVDSMRRHLISF-RRLNVQGHLTHMRRQRAKLVQTLEQYIFCH
.|...|..||||||||... ..|...... . ..    ..||||||||||||.| ....| . ..| .  ......  . ..|.||...|||.|||.|..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAIR
.|. 
rall
subfamily_CG42327_pd Subfamily CG42327 673-828 4.5e-29 96.1 In-house 29-187 (319) alignment 
Range on Protein: 673-828
Range on HMM: 29-187/319.0
SQKNRYNNIGAIEATRIRLNS---PTGNDYINANYVDSCNE-RNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQ--DSPQ
 .|.|. |.  .  ||. |..      . |..|.||   .. .| |||.|..| .. |||| ..|. .| .||..|.. | | ..| .|.|...  |. .
kdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnts

TFGNYQVTLVSESTNAHFSHRILDLKIAKavPAVERKVHQLHFmGWPDHGVPSSVFPLLSFV
..|...|||    .. ..    | ||  .      |..    .  |.. .||..  .|.. .
lyGdilvtlkgrevkdryaistlllkrvd..keesrelthywy.kwleaevPaeeaaliaml
0048076 (Phosphotyrosine protein) phosphatases II 756-903 1.9e-25 84.6 In-house 1-142 (145) alignment 
Range on Protein: 756-903
Range on HMM: 1-142/145.0
QYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLkiAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHSTG-PVVVHCSAGVGRSGSY
.||||. .    .|.. ..|  |    .   ..|.|  .   . .||.. |.....|||||||..   ||.|...  .... | ||.|||||||||.|..
pywpseilpglylgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

ILVDSMRRhlisfRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQL
.. . |..     ......  | ..|.|| . |.. .|..|..|....|
vaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefelel
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 651-762 2.4e-24 80.7 In-house 23-154 (350) alignment 
Range on Protein: 651-762
Range on HMM: 23-154/350.0
ESQTSGIDSVDsGESN----SSSDENSQKNRYNNIGAIEATRIRLN-----------SPTGNDYINANYVDSC------NERNAYIATQAPLPSTFSDFW
.|..|   . .  .||    |.  |   ||||.||   | .|..|.           |  .||||||||.         |    |||||||||||. ||.
ksrlsLesdse.spsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfy

SMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQ
 .| .   ..|. .|. || . .||..||.  .
kvillnkvkvilsltsdvelnlekcyrYWqegs
0048179 (Phosphotyrosine protein) phosphatases II 758-898 3e-23 77.6 In-house 3-139 (144) alignment 
Range on Protein: 758-898
Range on HMM: 3-139/144.0
WPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSDIHS-TGPVVVHCSAGVGRSGSYIL
.||. ..   .|.. ..|  |   ..    ...|      . .|| ..|.....|||||||..   ||.|...  ....  |||.|||||||||.|....
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

VDSMRrhlisFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHE
 . |.      ..|...  | ..|..|   |.. .|..|..|
aylmk.....klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 718-858 1.2e-22 74.7 In-house 97-242 (302) alignment 
Range on Protein: 718-858
Range on HMM: 97-242/302.0
QAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNA-HFS------HRILDLKIAKAVPAVERKVHQLHFM
  |  ||   .|..| | .  |.| ....|||...|| .|.  . .   .||.| |. ||  |.  .|.         ...|  |   .|.. |. |.| 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWPDHGVPSSVFPLLSFVHYTSDIHSTgpVVVHCSAGVGRSGSYILVD
.||||| |    . |  ...      .  |.|||||||||.|. . . 
awpdhGapkeaytaldilkfcesykkn..vlvhcsaGvGrtGtlvaik
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 678-901 2.2e-22 74.5 In-house 24-256 (290) alignment 
Range on Protein: 678-901
Range on HMM: 24-256/290.0
YNNIGAIEATRIRLNS---PTGNDYINANYVdSCNERNAYIATQAPLP-------STFSDFWSMIWQERSNIIVCITNMVEDGKR----KCDQYWPSQQD
  ..  .||||. |.       .||| ||.| .| .  . |.||.|.        ||  .|| |. ||... .| . .. |  .      | .| | . .
RlevpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvg

SPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAvpaVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSdiHSTGPVVVHCSAGVGRSGSYILVDSMRRH
   .|.. .|   |  ..  . .| | .|  .    .| .|    . || .  |. .   ||| ...     |. ||.|||  |. ||     ..     
eelkfkgltvkCkskekeddvetRelvvkfdde...eeftvtHsllkgWnklnvqedtktllsliqkvk..asktpvivHcvdGiSrsAalaaiilgyQk

LI-SFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIR
.. .   ....  |  .|.|||..... ... |   .| 
iaetsgsvkledvlkalrkqralaitsalelafvdagiv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 801-998 2.8e-21 70.4 In-house 88-270 (440) alignment 
Range on Protein: 801-998
Range on HMM: 88-270/440.0
ERKVHQLHFMGWPDHGVPSSVFPLLSFVHY---TSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCH
 | ..| |. ||||.|||  . |.| ...    . .  . ||..||||||.||.|  | |||. |.     ....   .  || .| ..||| ||| | |
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

EAIRQLIRHGITRVHSDLFMRYLHylseenlngktrmQLQFEDicdcKHQPRCLIESDvitLPGYHRSDEFMVGSWG--NECEDLWRLTWQQKVQTIVIL
||. . .  | | .  |     ..             |.|. .     |  .. .. .   . || . . |.           |.|||  . .. ||..|
eavlegllcgdtliledditerve.............qiqwpn....phtdksplqqe...fegyskknafiatqmpldstvldfwrlvhdyristiiml

NQR
|| 
nql
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 714-893 8.5e-19 62.6 In-house 37-210 (255) alignment 
Range on Protein: 714-893
Range on HMM: 37-210/255.0
YIAtqaplpsTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKavPAVERKVHQLHFMGWP
|.        |   |. .| | ... .| .... |.|. ||..|.| ..|  . . . .||    |..  .  . . .....      ..|.  .. ||.
ysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlge..kkkthtvkhysykGWi

DHGVPSSVFPLLSFVHYTSDihStGPVVVHCSAGVGRSGSYILVDSMRRHLI------SFRRLNVQGHLTHMRRQRAKLVQTLEQY
..  |     .|  ..   |  |  .||||||.|.||| ...|.... ...|      .   |.    |...| .|.. ..|  | 
eknaPelareilnilkvvrd..s.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 670-909 1.4e-18 61.3 In-house 49-290 (302) alignment 
Range on Protein: 670-909
Range on HMM: 49-290/302.0
DENSQKNRYNNIGAIEATRIRLNSpTGNDYINANYVDSCNERNAYIATQAPLPSTF---SDFWSMIWQERSNIIVCITnMVEDGKRKCDQYWPSQQDSPQ
 .|..||. ... ........|.  . ..|.||  |.  . ..  | .| |  ..     .|| |..||.   .| .  . |. |.  ....| .... .
kknlkknqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilv.geeelkktlselfpkksgdyk

TFGNYQVTL--VSESTNAH--FSHRILDLKIAKAVPAverKVHQLHFmgWPDHGVPSSVFPLLSFVHY--TSDIHSTGPVVVHCSAGVGRSGSYILVDSM
..|.  |    |... ...  ..  .|   .. .| |   .|  |..  |... || ..  |   ..   ...|... ..|.    |.|| |. . .   
eygkmfvNnrkVekaeeektryviEvlPegcsnsvla...nvyvltn..WkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlava

RRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGIT
  .| .    |..  .. .| ||.. |..|.||.. . |.  .|.. .|
veklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 712-896 2.4e-17 57.7 In-house 5-196 (199) alignment 
Range on Protein: 712-896
Range on HMM: 5-196/199.0
NAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLHFMG
  ||||| ||  |..||| |.|.  |  || . .   . .     |||. . .   .|.  ||  . .|.. ..   | |    . |   |.. .  |  
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPSsVFPLLSFVHYTSDI------HSTGPVVVHCSAGVGRSGSYILVDS-MRRHLISFRR-LNVQGHLTHMRRQRAKLVQTLEQYIFC
| ..  |  |  .. ||  . ..          ||.|||| | | .| .. .|  .| |  |    ...      .|. |  .. .|..| | 
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 712-896 2.6e-17 57.7 In-house 4-195 (198) alignment 
Range on Protein: 712-896
Range on HMM: 4-195/198.0
NAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKAVPAVERKVHQLHFMG
  ||||| ||  |..||| |.|.  |  || . .   . .     |||. . .   .|.  ||  . .|.. ..   | |    . |   |.. .  |  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPSsVFPLLSFVHYTSDI------HSTGPVVVHCSAGVGRSGSYILVDS-MRRHLISFRR-LNVQGHLTHMRRQRAKLVQTLEQYIFC
| ..  |  |  .. ||  . ..          ||.|||| | | .| .. .|  .| |  |    ...      .|. |  .. .|..| | 
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 671-902 2.9e-17 57.3 In-house 46-277 (303) alignment 
Range on Protein: 671-902
Range on HMM: 46-277/303.0
ENSQKNRYNNIGAIEATRIRLnspTGNDYINANYVDSCNERNAyIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSpQTFGN
.| .|||. ..  .. ....|   .   || |.|..   ...| | || ||. | .||| || ... . .. .    |  |   |  .| .||    | .
knmdknrfvdvicldhskvkl...sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.lkfee

YQVtLVSESTNAHFSHRiLDLKIAK-AVPAVERKVHQLHFMGWPDHGVPSS-----VFPLLSFVHYTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHL
  .  | |  .  ...    ||.   .       .|  |.  ||   .||      |  .     .      . | |    .|.||.|.. | ..    |
rsi.rvgefkrvelgdg.wvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahlsl

ISF-RRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQ
 |    |..   |  .|  | . || | |. . .  . .
hseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 684-762 9.4e-17 55.3 In-house 77-157 (349) alignment 
Range on Protein: 684-762
Range on HMM: 77-157/349.0
IEATRIRLNSPTGNDYINANYVD--SCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQ
|.|..   .|   .|||||||.     .  . |||||||||||  ||. .|  .. .... ...  | . .|||.||   .
ikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqels
subfamily_hpo-7_pd Subfamily hpo-7 715-889 8.8e-16 52.6 In-house 41-212 (263) alignment 
Range on Protein: 715-889
Range on HMM: 41-212/263.0
IAtqapLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFGNYQVTLVSESTNAHFSHRILDLKIAKavPAVERKVHQLHFMGWPD
.     |  |   |...| | ... .| .... |.|. ||..|.| ..|  | . | .|.      .     . |   . .      ..|..  . ||..
sl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlge..KkkthtvkhysykgWie

HGVPSSVFPLLSFVHYTSDIhstGPVVVHCSAGVGRSGSYILVDSMRRHLI------SFRRLNVQGHLTHMRRQRAKLVQT
.  |      |  .. . .     ..|||||.|.||| .. ..... ...|      |   |.    |...| .|.. ..|
kndpelareilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraiht
0036941 (Phosphotyrosine protein) phosphatases II 923-1154 9.6e-16 53.4 In-house 4-277 (297) alignment 
Range on Protein: 923-1154
Range on HMM: 4-277/297.0
LSEENLNGKTRMQLQFEDICDCKHQPRCLIESDVI-------------------------------TLPGYHRSDEFMV--GSWGNECEDLWRLTWQQKV
.  |.|....... .||......... . . . .                                 ..||... .|..  | . | .|| ||. |.|.|
kllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

QTIVILNQRDSFWR-KLPSCIYDG-EIQLQHGDNFVLLQKDDQ----QLCVRIVNVSRAdldtdfwreieNVQKQRITYHdaplliLAHKYPPSVPSPTD
..|| |.. .. .| | ...  .  .  |..|| .| |.. ..      ..| . |.             . ...|. .|      . ..  |    |..
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt...........gngesrtvth......fhytgwpdhgvpes

STSTLSLSILFNDDTALAFS-----------------ICAATTLACQLE---TTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYEKMSQLV
 .| |..  |...  .|. |                 ..|| .. .|||   ..|.||..... .. |  .|.. . .  . .|| . .|.
paslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 923-1148 2.6e-15 52.1 In-house 3-266 (273) alignment 
Range on Protein: 923-1148
Range on HMM: 3-266/273.0
LSEENLNGKTRMQLQFEDICDCKHQPRCLIES----------------------------DVI---TLPGYHRSDEFMV--GSWGNECEDLWRLTWQQKV
|  |.|.|.|.....||.....|..  . . .                            | |    ..||... .|..  | . | .|| ||. |.|.|
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

QTIVILNQRDSFWRKLPSCIYDGEI---QLQHGDNFVLLQKDDQQLCVRIVNVSRADLDTDFWREIENVQKQRITYHDAP--------LLILAHKYPPSV
..|| |.. .. .|.     .  |     |..|. .| | . ..  .. . ..   .|.|.  |..  ..   .  |..|        .. |..|.  ..
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

PSPtdststlslsilfndDTA---------LAFSICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYE
||.                .           . ...|. .| .|||..|.||| ...  . .  .|.. . . .. .||
psn...............gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0043336 (Phosphotyrosine protein) phosphatases II 917-1149 8.9e-15 50.3 In-house 5-272 (278) alignment 
Range on Protein: 917-1149
Range on HMM: 5-272/278.0
MRYLHYLSEENLNGKTRMQLQFEDICDCKHqPRCLIE--------------------------------SDVI---TLPGYHRSDEFMVGSWGNE--CED
...|..| | .||.||...|.||.....|. . . |                                 || |   ...||.....| . .. ..  .||
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

LWRLTWQQKVQTIVILNQRDSFWRKLPSCIYDgEIQLQHGDNFVLLQKDDQQLCVRIVNVSRADLDTDFWREIENVQKQRITyhdapllilAHKYPPSVP
 ||. |...|.||| |.. . ..|.     .  .  |..|| .| |.| ...  . . .    .| ... |..  ..   .           |. |.|. 
FwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.........dhgvpesls

SPTDSTSTLSLSILfNDDTALAF----------SICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYEK
.  |   ..   .  ........           ..|. .| .|||..|.||. .... . |  .|.. . . .. .|| 
llldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
subfamily_eak_pd Subfamily eak 668-819 1.1e-14 48.6 In-house 48-196 (332) alignment 
Range on Protein: 668-819
Range on HMM: 48-196/332.0
SSDENSQKNrYNNIGAIEATRIRLNSPTGN--DYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSP
.  |. ..|   .|   .   .|| |   |   ||||  ..  .  . || | ..  .    || |. ...|  || . . || .  | |.|.| .    
arleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktree

QTFGNYQVTLVSESTNAHFSHRILDLKIAKAVpaveRKVHQLHFMGWPDHGVPS
  || ..|.  .   .. .  | | |.          .|.  .. || .  .| 
lkfGildverkefvkrniletrllelskGnet....hrvlhykvfGwtettlpk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 838-901 3.1e-14 47.5 In-house 229-292 (297) alignment 
Range on Protein: 838-901
Range on HMM: 229-292/297.0
GPVVVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIR
 ...|||||||||||  .| | .   |   |  .|.  |...| |||.|||||||. ....|. 
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 781-903 6.1e-14 46.5 In-house 197-343 (350) alignment 
Range on Protein: 781-903
Range on HMM: 197-343/350.0
NAHFSHRILDLKIAKAVPAVerkVHQLHFMGWPDH---GVPSSVFPLLS---------FVHYTSDIHSTGPVVVHCSAGVGRSGSYILVDSMRRHLIS--
. .  . . ....| . | |   |.||..  |.|      | |. . |          | .  .|   . |..||||||||| | .. .||.  ..    
dlkdnnsltaitlaasdPyv...vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeile

-----FRRLNVQGH--------LTHMRRQRAKLVQTLEQYIFCHEAIRQL
     .|.|.|. .        . ..|.|| ..||.|.|.||..||.. .
nltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
fn3 Fibronectin type III domain 142-222 7.2e-14 44.9 Pfam-A 2-82 (85) alignment 
Range on Protein: 142-222
Range on HMM: 2-82/85.0
APSSPEIKTFTNRSITLVWTHNAaRAHRPILRFSVSVRTVSDNT-RFVMAAPSNATTVIVDNLSPYTLYAFSVRAENSAGSS
||. . ..  |..|.|| |.. .   ..|| ...| .|.....       .|...|.|.. .| |.| | |.|.| | || .
aPenlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngageg
0051299 (Phosphotyrosine protein) phosphatases II 915-1150 6.8e-13 44.2 In-house 9-282 (288) alignment 
Range on Protein: 915-1150
Range on HMM: 9-282/288.0
LFMRYLHYLSeenLNGKTRMQLQFEDICDCKHQPRCLIESDVI-----------------------------------TLPGYHRSDEFMV--GSWGNEC
 .......|    .||.|... .||......... . . . .                                     ..||... .|..  | . | .
ellklvlkll...angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntv

EDLWRLTWQQKVQTIVILNQRDSFW-RKLPSCIYDgEIQLQHGDnfvllqkddqqLCVRIVNVSRadLDTDFWREIENVQKQRITYHDAPLLILAHKYP-
|| ||. |.|.|..||.|.. . .  .| . .  . .  |..||           ..|.....    ||.  .|..| . .. ..... .. .  . |. 
edFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygd...........itvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytn

-PSVPSPTDSTSTLSLSILFNDDT---------------ALAFSICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYEKM
 |    |.. .. |..  |...                   .  ..|. .| .|||..|.||| ...  . |  .|.. . . .. .|| .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 666-762 1.4e-12 41.8 In-house 90-182 (244) alignment 
Range on Protein: 666-762
Range on HMM: 90-182/244.0
NSSSDENSQKNRYNNIGAIEATRIRLNS-PTGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDgkrkcDQYWPSQQ
.. . .|| |||      ..  |. |.    || |||| .|        || || ||  |  ||| |. .   |..| .  . |.     |.|||  .
dafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywpdse
0045450 (Phosphotyrosine protein) phosphatases II 920-1153 2.8e-12 42.5 In-house 15-303 (307) alignment 
Range on Protein: 920-1153
Range on HMM: 15-303/307.0
LHYLSEENLNGKTRMQLQFEDICDCKHQPRCLIE----------------------------------------------SDVITLPGYHRSDEFMV--G
| .. .. |...|... .||......... . ..                                               ....|.||.....|..  |
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

SWGNECEDLWRLTWQQKVQTIVILNQRDSFWR-KLPSCIYDGEIQLQHGDNFVLLQKDDQQLCVRIVNVSRADL-DTDFWREIENVQKQRITYHDAPL--
 . . .|| ||. |.|.|..|| |.. . ..| | .    | . .|..|. .| | . ...  . . ..   ||  |.. |..   .  .   |..|   
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

------LILAHKYPPSvpsptdststlslsilFNDDTALAF----------SICAATTLACQLETTGC---VDVVQVLSSYTEIQCGIFASKQEIEIIYE
      . ...|.  .                 ....  .           ...|| .. .|||..|.   ||. .... . |  .|.. . . .. .||
eelldfieevrkalee................lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye

KMSQL
 . .|
allel
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 623-718 3.4e-12 40.4 In-house 5-94 (95) alignment 
Range on Protein: 623-718
Range on HMM: 5-94/95.0
IPVELFYGYVEDLNRNDSLKFKTQFQILeSQTSGIDSvdsgeSNSSSDENSQKNRYNNIGAIEATRIRLNSPTGNDYINANYVDSCNERNAYIATQ
| | .|. .| ..  |   .|  .|. . | |||        .  ||. |  |||. ||   .|||. | .    ||||| .||    .|.|||.|
ihvsvfhshvlemhsnsdqefdnefksi.smtsgapy.....tvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgyarkncyiaaq
subfamily_CG42327_pd Subfamily CG42327 835-899 9.6e-12 39.2 In-house 245-310 (319) alignment 
Range on Protein: 835-899
Range on HMM: 245-310/319.0
HSTGPVVVHCSAGVGRSGSYILVDSMRRHL-ISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEA
.| ||.||||| ||||.|  |  |   |.|  | | ...   . ..||.||. |.| ||| | .  
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 692-813 8.4e-11 36.3 In-house 11-122 (130) alignment 
Range on Protein: 692-813
Range on HMM: 11-122/130.0
NsptGNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVEDgkrkcDQYWPSQqdSPQTFGNYQVTLVSESTNAHFSHRILDL
.   ||.||||..|   .  . |. ||.||  |  ||| |. .   |..| .  . |.     |.|||     |  . . .... .   .     .   |
q...gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpds..ePlewyeediivtltdrdefknikasnl

KIAKAVPAVERKVHQLHFMGWP
.| . .    . .  ..   ||
eiesdlneshqaltmfqisnwp
0039614 (Phosphotyrosine protein) phosphatases II 924-1154 8.8e-11 37.3 In-house 24-289 (297) alignment 
Range on Protein: 924-1154
Range on HMM: 24-289/297.0
SEENLNGKTRMQLQFEDICDCKHQPRCL-------------------------------IESDVI---TLPGYHR-SDEFMVGSW--GNECEDLWRLTWQ
  |..|.||...|.||.....|.  ..                                 .|| |    ..||.. ...| . ..   . .|| ||. |.
llekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

QKVQTIVILNQRDSFWRKLPSCIYDGEIqlQHGDNFVLLQKDDQQLCVRIVNVSRADldTDFWREIENVQKQRITYHDAP--------LLILAHKYPPSV
|.|..|| |.. .  .|| ..   . .   ..|| .| | | ..   . . . .  .  ..  |..  .|   .  |..|        .| |....  . 
qgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealael

psptdststlslsilfNDDTALAF----------SICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYEKMSQLV
                ....  .           ...|| .. .|||..|.||| .... . |  .|.. . . .. .|. . .|.
................pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
fn3 Fibronectin type III domain 348-428 2.6e-10 33.5 Pfam-A 12-85 (85) alignment 
Range on Protein: 348-428
Range on HMM: 12-85/85.0
GKPEITVLWPAPPlNATEKVIKYHLYYKAKNEDQwKIEHLNVSPNgvkskLFKYRLVDLNPNTQYRIRVSASTIKGEGAQS
.  ..|. | .|. .  ... .| . |. |.. . .  . .|...        . | .|.|.|.|..|| | . .|||  |
tstsltlsWsppk.dgggpitgYeveyrekggge.ewkeftvprt.....ttsvtltgLkpgteYefrVqavngagegpeS
subfamily_PTPDC1_pd Subfamily PTPDC1 807-902 4.4e-10 34.3 In-house 85-174 (182) alignment 
Range on Protein: 807-902
Range on HMM: 85-174/182.0
LHFMGWPDHGVPSsVFPLLSFVHYTSDIHSTGPVVVHCSAGVGRSGSYILVdsmrrHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQ
 . .||.|.||.| .  .|  |   .   . | | ||| || || |  | .     .|.  .||. .  .. .| .|.| .|| ||  ...|    
vynfgwkDygvas.leriLdivkvvafalqegkvavhChaGlGrtGvliac.....ylvyakrltaekaiklvrskrpksiqtreqvelvkefalf
0040439 (Phosphotyrosine protein) phosphatases II 960-1153 5.7e-10 34.7 In-house 48-245 (249) alignment 
Range on Protein: 960-1153
Range on HMM: 48-245/249.0
PGYHRSDEFMVGSW--GNECEDLWRLTWQQKVQTIVILNQRDSFWRKLPSCIYDGEIQLQHGDNFVLLQKDDQQLCVRIVNVSRADLdtdfwREIENVQK
.||.....| . ..   . .|| ||. |......|| |.. . ..|.    ... .  |..|| .| | . ..   . . ..   .|      . | .. 
dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnl.....ydgesrtv

QRITYHDAPllilAHKYPPSVPSPTDSTSTLSLSILFN-DDTALAF----------SICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEII
. | |.| |     |. |||...  |    .   .  . ... ...           ..|| .. .|||....||. .... . .  .|.. . . .. .
lhiqytdwp....dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

YEKMSQL
|| . .|
yeallel
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 710-797 7e-10 32.8 In-house 234-317 (440) alignment 
Range on Protein: 710-797
Range on HMM: 234-317/440.0
ERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCItNMVEDgkRKCDQYWPSQQDSpQTFGNYQVTLVSESTNAHFSHRILDLKIAKAV
 .||.|||| || ||  ||| .. . |   |. . | ..|  . |  ||| .  |  ||| . |             | |.||  . |
kknafiatqmpldstvldfwrlvhdyristiiml.nqlnd..ktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeev
ig Immunoglobulin domain 78-116 7.7e-10 30.0 Pfam-A 15-63 (64) alignment 
Range on Protein: 78-116
Range on HMM: 15-63/64.0
ADSSRQWWVSDGRYQLIRPFYT----------LRVSPVTPEDSGTYRCR
 . . .|......... .....          | ...||.||||||.|.
pstdvsWykegkgleesqktgvvenrvsaqevLtinnvtkedsGtYtCv
0042113 (Phosphotyrosine protein) phosphatases II 960-1152 1.7e-09 32.9 In-house 46-241 (245) alignment 
Range on Protein: 960-1152
Range on HMM: 46-241/245.0
PGYHRSDEFMVGSW--GNECEDLWRLTWQQKVQTIVILNQRDSFWR-KLPSCIYDgEIQLQHGDNFVLLQKDDQQLCVRIVNVSRADLdtdfwreIENVQ
.||.... | ....   . .|| ||. |.....||| |.. . ..| | .    . .  |..|| .| | . ..   . . ...  .|        .. .
dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesltygdftvtllseehlddytvrtlevtnl.......gddes

KQRITYHDAPLLilAHKYPPSVPSPTDSTSTLSLSILFNDDTALAF----------SICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEII
.. |.||  |     |. |... .  |  . .   .  .... ...           ..|| ....|||....|.. ...  . .  .|.. . . .. .
revihyhylpwp..dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

YEKMSQ
|| . .
yealle
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 670-749 2.5e-09 31.1 In-house 35-122 (347) alignment 
Range on Protein: 670-749
Range on HMM: 35-122/347.0
DENSQKNRYNNIGAIEATRIRLN------SPT--GNDYINANYVDSCNERNAYIATQAPLPSTFSDFWSMIWQERSNIIVCITNMVED
. . .||| ..   |.|||. |       |..   . |||| ..   | .. || || |||.|  ||| |.   .   .| | . ..|
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
fn3 Fibronectin type III domain 240-321 4.2e-09 29.6 Pfam-A 2-83 (85) alignment 
Range on Protein: 240-321
Range on HMM: 2-83/85.0
PPQIQKIRNITSECVEVTITPPDEMNGELDKYLVLIQAVNETIPRKMTFDKPTSTPLTICALSPSTDYALAIEADNGFGTSP
.|.  .....||  .... .||.. .|....| |  . .... . |    ..|.| .|.  | |.|.| . ..| || |..|
aPenlsvsevtstsltlsWsppkdgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVqavngagegp
0046845 (Phosphotyrosine protein) phosphatases II 975-1149 1.1e-08 30.2 In-house 88-269 (284) alignment 
Range on Protein: 975-1149
Range on HMM: 88-269/284.0
NECEDLWRLTWQQKVQTIVILNQRDSFWR-KLPSCIYDGEIQLQHGDNFVLLQKDDQQLCVRIVNVSRADLD-TDFWREIENVQKQRITYHDAP------
| .|| ||. |.|.|..|| |.. ... | | .    . .  |..|| .| | . ... .. . ...  .|. |...|..   .   .  |..|      
ntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedl

--LLILAHKYPPSvpsptdststlslsilF-NDDTAL---------AFSICAATTLACQLETTG---CVDVVQVLSSYTEIQCGIFASKQEIEIIYEK
  .| |.... ..                . .. . .         .  ..|. .| .|||..|   .||| .... . |  .| . . . .. .|| 
leflrlvrellen................lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyea
0040438 (Phosphotyrosine protein) phosphatases II 920-1149 2e-08 29.3 In-house 6-271 (317) alignment 
Range on Protein: 920-1149
Range on HMM: 6-271/317.0
LHYLSEENLNGKTRMQLQFEDICDCKHQpRCLI--------------------------------ESDVI---TLPGYHRSDEF--MVGSWGNECEDLWR
|..|   .....|... .|||....|.   . .                                .|| |     .|......|  . | . | .|| ||
llalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

LTWQQKVQTIVILNQRDSFW-RKLPSCIYDgEIQLQHGDNFVLLQKDDQQLCVRIVNVSRADLDTDfwreienvqKQRITYHDAPLLILAHKYPPsvpSP
. |.|.|..|| |.. . .. .|      . .  |..|| .| |.. ..   . . ..   ||...         ..|. .|   .    |. ||   ||
mvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgds.........esrtvthfhytgWpdhgvpp...sp

TDSTSTLSLSILF--NDDTALAF----------SICAATTLACQLETTGCVDVVQVLSSYTEIQCGIFASKQEIEIIYEK
..  . |..   .  .... ..           ...|| .. .|||..|.||| ...  . |  .|.. . . .. .|. 
dllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0038934 (Phosphotyrosine protein) phosphatases II 801-897 3.4e-08 28.9 In-house 76-170 (194) alignment 
Range on Protein: 801-897
Range on HMM: 76-170/194.0
ERKVHQLHFMGWPDHGVP---SSVFPLLSFVHYTSDIHSTGPVVVHCSAGVGRSGSYILvdsmrRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCH
|.   . . . .||.|..   . ..  |..|.   . .. | |.||| ||.||.|  .      ..||  ......  . ..|. | . ... ...   .
ekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 841-902 1.5e-07 25.7 In-house 2-63 (69) alignment 
Range on Protein: 841-902
Range on HMM: 2-63/69.0
VVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQ
|||||.| ||.|..| .      . | . ...   . .||. |  .|    .||| |.|. .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 672-754 1.7e-07 25.0 In-house 34-118 (332) alignment 
Range on Protein: 672-754
Range on HMM: 34-118/332.0
NSQKNRYNNIGAIEATRIRLNSPTGN-DYINANYVDSCNERNAYIATQAPLPS-TFSDFWSMIWQERSNIIVCITNMVEDGKRKC
| . ||   . ... .|. |    |. |. ||..||  ....||| .|||.   |   || |. . . ..|. . .. |  |||.
nmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 841-904 6.4e-07 23.6 In-house 1-64 (69) alignment 
Range on Protein: 841-904
Range on HMM: 1-64/69.0
VVHCSAGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLI
|||||.| ||.|..| .      . | . ...   . .||. |  .|   ..|.| |.|. . .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 829-900 6.7e-07 22.9 In-house 259-340 (349) alignment 
Range on Protein: 829-900
Range on HMM: 259-340/349.0
HYTSDihSTGPVVVHCSAGVGRSGSYILVDSMRR----HLISFRRLNVQGHL--------THMRRQRAKLVQTLEQYIFCHEAI
.. .|   . ...|||||| ||.| .. .|..          . ....|  |         ..|.||  .|| | |.|...||.
yldtd..qlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyeal
subfamily_CG7180_pd Subfamily CG7180 960-1030 2e-06 21.7 In-house 79-150 (296) alignment 
Range on Protein: 960-1030
Range on HMM: 79-150/296.0
PGYHRSDEFMVGSWGNE--CEDLWRLTWQQKVQTIVILNQRDSFWRKLPSCIYDGEiQLQHGDNFVLLQKDDQ
 .. .  |..|  .  .   .. ||| ........|.| .  .| .. || .     . |.|. || . . .|
dsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqygeifveiveekq
PTEN_1 803-853 4.1e-06 21.7 In-house 94-146 (196) alignment 
Range on Protein: 803-853
Range on HMM: 94-146/196.0
KVHQLHFmGWPDHGVPSSVFPLLSFVHYTSDIHS---TGPVVVHCSAGVGRSGS
.| .||| ...|||.||  . .   .   . . |    . |.||| ||.|||| 
gveylhf.pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGt
subfamily_PTPRK_pd Subfamily PTPRK 960-1067 4.5e-06 20.7 In-house 80-190 (314) alignment 
Range on Protein: 960-1067
Range on HMM: 80-190/314.0
PGYHRSDEFMVGS--WGNECEDLWRLTWQQKVQTIVILNQRdSFWRKLPSCIYDGEIQLQHGDNFVLLQ--KDDQQLCVRIVNVSRADLDTDFWREIENV
 .|.|. .|.|      .  .|.||| ....  .||.|..      ... . |  |   ..||  | |   . ...| ||| .|...    .  ||. ..
dsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqf

QKQRITYHDAPL
|  . . || | 
qflgWpdhdvPv
DSPc Dual specificity phosphatase, catalytic domain 826-889 6.7e-06 21.0 Pfam-A 64-120 (133) alignment 
Range on Protein: 826-889
Range on HMM: 64-120/133.0
SFVHYTsdIHSTGPVVVHCSAGVGRSGSYILvdsmrRHLISFRRLNVQGHLTHMRRQRAKLVQT
.|..    . . . |.||| ||. ||.. |.     ..|.. ..|...  . .....| |....
efieka..eqkgkkvlVHCqaGisRSatlii.....aYlmktknlslneAyefvkerrskispn
DSPc Dual specificity phosphatase, catalytic domain 826-889 6.7e-06 21.0 In-house 64-120 (133) alignment 
Range on Protein: 826-889
Range on HMM: 64-120/133.0
SFVHYTsdIHSTGPVVVHCSAGVGRSGSYILvdsmrRHLISFRRLNVQGHLTHMRRQRAKLVQT
.|..    . . . |.||| ||. ||.. |.     ..|.. ..|...  . .....| |....
efieka..eqkgkkvlVHCqaGisRSatlii.....aYlmktknlslneAyefvkerrskispn