Gene R06B10.2 in Caenorhabditis elegans

Synonym: CELE_R06B10.2, R06B10.2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP168_AA protein Get Run
CeleP168_AA_744-942 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 781-950 3.9e-59 195.2 In-house 112-281 (290) alignment 
Range on Protein: 781-950
Range on HMM: 112-281/290.0
ASSEYFPLKKNEICEFEGGSVKCTNYEREYiGIITRKLTLNFDDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKYETTAIVHCVDGVSRSAVLAG
| ..|.| . .|.  |.| .|||.. | |  ...||.|...|||.|||..||... .|| ||. ||.. .  .........|..|||||||.||||.|| 
aCakYvpesvgeelkfkgltvkCkskeked.dvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaa

MIIGFQKIIETRGDMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLLFKRMMNNFEEEYPE-DLKQMLKD
.|.|.|||.||.|.....|....||||||.|||| ||||||||||.||.......|.||..|   |.  |.
iilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeeke
0040438 (Phosphotyrosine protein) phosphatases II 745-944 2.5e-30 101.3 In-house 51-304 (317) alignment 
Range on Protein: 745-944
Range on HMM: 51-304/317.0
EVPLLEATRVVLKGYGKRFADDYIHASYVTYGQ----------------------------------------AFVASSEYFPLkkNEICEFEGGSVKCT
 .......||.|. .|... .|||.||||.  .                                          . . .|.||  .|  .... .|...
dilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtll

NYEReYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY----ETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRGDMNVAD
..|  . ||. |.|..   .|.|....||.. ..|   .. ....       .. ..    ..  .|||..||.|....... . .. . |..|...| .
seee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleql.ekeggvdvee

LIDDLRKQRAMAITSGLELAFVDAGIFLLFKRMMN-------------NFEEEYPEDL
 .. ||.||..|...   . |.   .. ..|| ..             .... ...| 
avkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddv
0050432 (Phosphotyrosine protein) phosphatases II 745-933 4e-27 90.8 In-house 76-303 (308) alignment 
Range on Protein: 745-933
Range on HMM: 76-303/308.0
EVPLLEATRVVLkgygkRFADDYIHASYVTYG------------------------------------------QAFVASSEYFPLKKN-EICEFEGGSV
 .. .. .||.|        .|||.||||.                                               .   .|.||. . .. |... .|
dilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftv

KCTNYEReYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY--ETTAIVHCVDGVSRSAVLAGMIIGFQKIIETrGDMNVA
.....|  . ....|.|.| . .|||....|| . ..|   .. .. .       .. |.  . . .||| .||.|..... . . .. . .. | ..| 
tllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvf

DLIDDLRKQRAMAITSGLELAFVDAGIFLLFKRMM
...  ||.||......   . |.   .. ..|...
eavkklReqRpgmvqtpeqylflyralleylklkl
0036941 (Phosphotyrosine protein) phosphatases II 745-932 4.5e-27 90.5 In-house 47-280 (297) alignment 
Range on Protein: 745-932
Range on HMM: 47-280/297.0
EVPLLEATRVVLkgygKRFADDYIHASYVTYGQ----------------------------------------AFVASSEYFPLKKNEICEFEGGSVKCT
 .. .. |||.|    .   .|||.||||.  .                                         ..   .|.||...|  .... .|...
dilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtll

NYER-EYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK------YETTAIVHCVDGVSRSAVLAGMIIGFQKIIE--TRGD
..|  .. ....|.|.. . ..||....||.....|   .. |...       .. |       ..  .|||..||.||...... . .| . .  ..| 
svevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkegg

MNVADLIDDLRKQRAMAITSGLELAFVDAGIFLLFKRM
... ...  ||.||..|...   . |.   .. |.|. 
vdileavkklReqRpgavqtleqyrflyeallellkkk
0039614 (Phosphotyrosine protein) phosphatases II 745-931 9.6e-26 86.3 In-house 64-291 (297) alignment 
Range on Protein: 745-931
Range on HMM: 64-291/297.0
EVPLLEATRVVLKGYGKR-FADDYIHASYVTYGQA-----------------------------------------FvASSEYFPLKKNeicEFEGGSVK
... .. .||.||..... . .|||.||||.                                                  .|.| . .   .... .|.
dilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvt

CTNYEReYIGIITRKLTLNFdDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK------YETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRGDMN
....|  . |...|.|..   .||....||.|...|   .. ....    .  ....       ..  .|||..||.|....... . .. . |..|...
llkveh.ldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql.ekeggvd

VADLIDDLRKQRAMAITSGLELAFVDAGIFLLFKR
| . .. ||.|| .|...   . |.   .. |.||
vleavkelreqRpgavqtpsqyrflydallellkr
0046845 (Phosphotyrosine protein) phosphatases II 745-933 1.4e-25 85.7 In-house 36-278 (284) alignment 
Range on Protein: 745-933
Range on HMM: 36-278/284.0
EVPLLEATRVVLKGYGKR-FADDYIHASYVTYG---------------------------------------------QAFVASSEYFPLKkNEICEFEG
 .. .. .||.|| ....   .|||.||||.                                                  .  . |.||. .|  ....
dilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygd

GSVKCTNYEReYIGIITRKLTLNFD--DGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY------ETTAIVHCVDGVSRSAVLAGMIIGFQKIIE
 .|.....|  . ....|.|.| .   .||....||.....|   .. .. .       .. ..      . . .||| .||.|..... . . .. ...
ftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlek

TRG--DMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLLFKRMM
..    ..| ...  ||.|| .....   . ||   .. ..|...
eglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0051299 (Phosphotyrosine protein) phosphatases II 745-921 1.6e-25 85.6 In-house 57-278 (288) alignment 
Range on Protein: 745-921
Range on HMM: 57-278/288.0
EVPLLEATRVVLKGYGKRFADDYIHASYVTYGQ----------------------------------------AFVASSEYFPLkkNEICEFEGGSVKCT
 .. .. .||.|. ...   .|||.|||..  .                                          . .  |.||  ..  ...  .|...
dilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtll

NYEReYIGIITRKLTLNF-----DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY----ETTAIVHCVDGVSRSAVLAGMIIGFQKIIETrGDM
..|  . ....|.|..        |||....||.....|   .. .. .      ....|.    . . .||| .||.|..... . . .. . .. | .
seev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggv

NVADLIDDLRKQRAMAITSGLELAFV
.| ...  ||.|| .....   . ||
dvleavkrlreqRpgmvqtpeqyrfv
0047943 (Phosphotyrosine protein) phosphatases II 745-921 2.1e-25 85.1 In-house 46-264 (273) alignment 
Range on Protein: 745-921
Range on HMM: 46-264/273.0
EVPLLEATRVVLkgygKRFADDYIHASYVTY---GQAF-------------------------------------VASSEYFPLKKNE-ICEFEGGSVKC
 .. .. .||.|    .   .|||.||||.    ...|                                     .    |.||. .|   ...  .|..
dilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtl

TNYEReYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK------YETTAIVHCVDGVSRSAVLAGMIIGFQKIIETrGDMN
...|  . ....|.|.| . ..||....||.....|   .. ..        ....|       ... .|||..||.|..... . . .. .... | ..
lseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvd

VADLIDDLRKQRAMAITSGLELAFV
| ...  ||.|| .....   . |.
vleavkllrsqRpgmvqtpeqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 745-918 5.3e-25 83.9 In-house 53-266 (278) alignment 
Range on Protein: 745-918
Range on HMM: 53-266/278.0
EVPLLEATRVVLKGYGKRFADDYIHASYVTYGQ----------------------------------------AFVASSEYFPlkkNEICEFEGGSVKCT
 ..... .||.|. .|... .|||.||||.  .                                          | . .|.|   ..  .... .|...
dilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtll

NYEReYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK----YETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRGDMNVAD
..|  . ....|.|..    |||....||.. |.|   .. |.         ....     ..  .|||..||.|....... . .. . |..| ... .
keeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleql.ekeggvdlee

LIDDLRKQRAMAITSGLEL
 ...||.||..|...   .
avkelreqRpgavqtpsqy
0040439 (Phosphotyrosine protein) phosphatases II 745-915 3.2e-24 81.3 In-house 19-232 (249) alignment 
Range on Protein: 745-915
Range on HMM: 19-232/249.0
EVPLLEATRVVLKGYGKRFADDYIHASYVTYGQ----------------------------------------AFVASSEYFPLkkNEICEFEGGSVKCT
 .. .. .||.|. ....| .|||.|||... .                                         ..   .|.||  ..  |... .|...
dilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtll

NYEReYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK------YETTAIVHCVDGVSRSAVLAGMIIGFQKIIETRGdMNV
..|  . ....|.|.| .  |||.....| |..||   .. ..   .      ..|       ..  .||| .||.|....... . .. . ...| ...
svev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelg.vdl

ADLIDDLRKQRAMAITSG
 . ...||.|| .|... 
eeavkllrsqRpgavqnp
0045450 (Phosphotyrosine protein) phosphatases II 745-916 1.1e-23 80.0 In-house 63-291 (307) alignment 
Range on Protein: 745-916
Range on HMM: 63-291/307.0
EVPLLEATRVVLKGYGKR-FADDYIHASYVTYGQ------------------------------------------------AFVASSEYFPLKkNEICE
...... |||.|. ....   .|||.||||.                                                   ...   .|.|.. .|  .
dilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geelt

FEGGSVKCTNYEReYIGIITRKLTLNF--DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK------YETTAIVHCVDGVSRSAVLAGMIIGFQK
..   |.....|  . |.. |.|..     .||....||.. ..| . .. ..   .      ..|       ..  .||| .||.|....... .  . 
ygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrq

IIETRGD--MNVADLIDDLRKQRAMAITSGL
. ..     ... . .. ||.||  |...  
lekegtlldvdlleavkllreqRpgavqnpe
0042113 (Phosphotyrosine protein) phosphatases II 745-914 1.5e-23 78.9 In-house 17-228 (245) alignment 
Range on Protein: 745-914
Range on HMM: 17-228/245.0
EVPLLEATRVVLKGYGKRFADDYIHASYVTYGQ----------------------------------------AFVASSEYFPLkkNEICEFEGGSVKCT
...... |||.|. .| .. .|||.||||.  .                                         .| . .|.||  .|. .... .|...
dilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtll

NYEReYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK-----YETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRGDMNVA
..|  . ....|.|..    |.|.....|.. |.| . .. ....    .  |. |      ... .||| .||.|....... . .. . |....... 
seeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql.ekelgvsle

DLIDDLRKQRAMAITS
. ...||.|| .|...
eavkelrsqRpgavqt
Y_phosphatase Protein-tyrosine phosphatase 782-924 1.2e-21 72.6 Pfam-A 84-232 (235) alignment 
Range on Protein: 782-924
Range on HMM: 84-232/235.0
SSEYFPLKKNEICEFEGGSVKCT-NYEREYIGIITRKLTLNFDDGEE--FKITHHQVLDWNGLNALEDHRGAGLAAMFLMKYE----TTAIVHCVDGVSR
 ..|.| ...| ....  .|... . ...  ....|||.|. ...|.  ........ .|.  .. |. ..       . |..    .  .||| .||.|
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgR

SAVLAGMIIGFQKIIETRGdMNVADLIDDLRKQRAMAITSGLELAFVDAG
..... . | .... ...  ..| ...  |||||.....|  ...|. . 
tgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYiflyka
Y_phosphatase Protein-tyrosine phosphatase 782-924 1.2e-21 72.6 In-house 84-232 (235) alignment 
Range on Protein: 782-924
Range on HMM: 84-232/235.0
SSEYFPLKKNEICEFEGGSVKCT-NYEREYIGIITRKLTLNFDDGEE--FKITHHQVLDWNGLNALEDHRGAGLAAMFLMKYE----TTAIVHCVDGVSR
 ..|.| ...| ....  .|... . ...  ....|||.|. ...|.  ........ .|.  .. |. ..       . |..    .  .||| .||.|
caqYwpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgR

SAVLAGMIIGFQKIIETRGdMNVADLIDDLRKQRAMAITSGLELAFVDAG
..... . | .... ...  ..| ...  |||||.....|  ...|. . 
tgtfvaldilleqleaeee.vdvlqivkelRkqRpgmvqsleqYiflyka
WSN Domain of unknown function 1-58 3.2e-21 65.0 Pfam-A 10-67 (69) alignment 
Range on Protein: 1-58
Range on HMM: 10-67/69.0
MQMISRITTGISMQYGLSNGTITFDDLIPELLHFGTITPTQISAITTDKLTEIVDGIN
...|.|.|.||. | ||.||.|..||.| |||..|.....|. .| .||| |......
lsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnkls
0045098 (Phosphotyrosine protein) phosphatases II 745-923 2.2e-20 68.6 In-house 41-266 (278) alignment 
Range on Protein: 745-923
Range on HMM: 41-266/278.0
EVPLLEATRVVlkgygkrfadDYIHASYVTY--------------------------------------GQAFVASSEYFPlKkNEICEFEGGSVKCTNY
... .. .||.          |||.|||...                                        . .   .|.|   ..  .... .|.....
dilpydhsrVk..........dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e.ggsltygdftvtllse

EREYIGIITRKLTLNF----DDGEEFKITHHQVLDWNGLNALEDH--RGAGLAAMFLMK-----------------YETTAIVHCVDGVSRSAVLAGMII
|.    .... |  |.     |.|....||.. | |   .. ...  .    .  |. .                  ... .|||  ||.|...|... .
evlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaayl

GFQKIietRGDMNVADLIDDLRKQRAM-AITSGLELAFVDA
  . .    | ... . .. ||.|| . |...   . |.  
mlell...eggvdlleavkelrsqRpglavqnleqyrflye
DSPc_SM00195 783-925 7.6e-19 63.4 In-house 112-258 (263) alignment 
Range on Protein: 783-925
Range on HMM: 112-258/263.0
SEYFPLKKNEICEFEGGSVKCTNYEREYIGIITRKLTLNFDDG-EEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY----ETTAIVHCVDGVSRSAV
..|.| ....  .|.  |||....| .   ||.|.|.|....  |..|.|..|. .|.  .. ....       .. |     ... .||| .||.|...
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgt

LAGMIIGFQKIIETRGdMNVADLIDDLRKQRAMAITSGLELAFVDAGI
.. . |  .|. |.   ... ...  |||||......  ...|.   |
fvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeai
PTPc_SM00194 783-925 7.6e-19 63.4 In-house 112-258 (263) alignment 
Range on Protein: 783-925
Range on HMM: 112-258/263.0
SEYFPLKKNEICEFEGGSVKCTNYEREYIGIITRKLTLNFDDG-EEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY----ETTAIVHCVDGVSRSAV
..|.| ....  .|.  |||....| .   ||.|.|.|....  |..|.|..|. .|.  .. ....       .. |     ... .||| .||.|...
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgt

LAGMIIGFQKIIETRGdMNVADLIDDLRKQRAMAITSGLELAFVDAGI
.. . |  .|. |.   ... ...  |||||......  ...|.   |
fvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeai
0037934 (Phosphotyrosine protein) phosphatases II 746-913 1e-15 53.4 In-house 19-226 (243) alignment 
Range on Protein: 746-913
Range on HMM: 19-226/243.0
VPLLEATRVVLKGygkrfaDDYIHASYVTYGQAFVASSE-----------------------------------------YFPlkkNEIcEFEGGSVKCT
..... .||.|.|      .|||.|....    . |..                                          |.|   .|. .... .|...
ilpydhsrvkleg......sdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtll

NYEReYIGIITRKLTLNF--DDGEEFKITHHQVLDWNGLNALEDHRG--AGLAAMF----------LMKYETTAIVHCVDGVSRSAVLAGMIIGFQKIie
..|  . ... |.|.|     |.... ..|.. | | . .. ...    . | ..             . . . .|||. ||.|...|. . .  ...  
seeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll..

trgDMNVADLIDDLRKQRAM-AIT
   .... . ...||.|| . |..
...gvdleeavkllreqRpgkavq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 780-949 4.4e-15 50.4 In-house 68-240 (255) alignment 
Range on Protein: 780-949
Range on HMM: 68-240/255.0
VASSEYFPLKKNEICEFEGGSVKCTNyEREYIGIITRKLTLNFD-DGEEFKITHHQVLDWNGLNALEDHRGAgLAAMFLMKYETTAIVHCVDGVSRSAVL
.  |.||||.|.|   ..  .| .|.     . . |...|...    .  ...|..   |   || |. |   |  . ...   . .|||  |. ||| .
ekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei.lnilkvvrdsksvvvhCstGiGrsaaf

AGMIIGFQKIIE-----TRGDMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLLFkRMMNNFEEEYPEDLKQMLK
. . . .||.|        ....   |...||..|. ||   |.|||    .. |.    ...|..| |  |  |.
vlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.fpkgeleakyqeirksylh
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 742-782 1e-14 49.4 In-house 23-65 (290) alignment 
Range on Protein: 742-782
Range on HMM: 23-65/290.0
EKVEVPLLEATRVVLKGYGKRFADDYIHASYVTY--GQAFVAS
...||||.||||||||||||||.||||||..||.  |......
qRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrlilt
subfamily_hpo-7_pd Subfamily hpo-7 780-940 8.3e-14 46.1 In-house 74-235 (263) alignment 
Range on Protein: 780-940
Range on HMM: 74-235/263.0
VASSEYFPLKKNEICEFEGGSVKCTNYEREYIgIITRKLTLNFD-DGEEFKITHHQVLDWNGLNALEDHRGAgLAAMFLMKYETTAIVHCVDGVSRSAVL
.  |.||||.|.|   ..  .| .|.   . . . |..|. ...   .  ...|..   |   |. |. |   |  . . .     .|||  |. |||  
ekcssyfPlekdekqklanvnvcttkvqsdvl.lktlellstlgeKkkthtvkhysykgWiekndpelarei.lnilkvarnskslvvhcstGiGrsaaf

AGMIIGFQKIIE-----TRGDMNVADLIDDLRKQRAMAITSGLELAFvdaGIFLLFKRMMNNFEEEY
. . . .||.|        ....   |...||..|. ||   . |||    |..... ..||| .. 
svaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf...silmvLdfvlnnfakge
subfamily_PTPN3_pd Subfamily PTPN3 783-927 9.9e-12 39.3 In-house 127-273 (280) alignment 
Range on Protein: 783-927
Range on HMM: 127-273/280.0
SEYFPLkKNEICEFEGGSVKCTNYeREYIGIITRKLTLNFDD-GEEFKITHHQVLDWNGLNALEDHRGAgLAAM---FLM--KYETTAIVHCVDGVSRSA
 .|.|  ... .|. . ||||..  .|   ...|.|.|.  .  || ||.. | |.|   .  .|.    |  .     .    |.  .|||  |. |. 
hqyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadf.lefvervrklrsgkeePvvvhCsaGigrtG

VLAGMIIGFQkIIETRGDMNVADLIDDLRKQRAMAITSGLELAFVDAGIFL
||  . . .. .||.. .... |..  .| |||| . .     ||   |. 
vlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 783-928 3e-11 37.8 In-house 107-263 (270) alignment 
Range on Protein: 783-928
Range on HMM: 107-263/270.0
SEYFPLKKNEICEFEGGSVKCTNYE-REYIGIITRKLTLNfDDGEEFKITHHQVLDWN--GLNALED--HRGAGLAAMF----LMKYET----TAIVHCV
. |.| ...|  ..| | .| .. . .   | |...|.|. ..||| ...|..  .|.  |    ||   .   | .|.     .. |.      .||| 
erYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

DGVSRSAVLAGMIIGFQkIIETRGDMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLL
.|| |. .|  . |... ..|... ..|. .|..|||.|   .    . .|. ... . 
aGvgRtGtlialDiavr.lLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
0049772 (Phosphotyrosine protein) phosphatases II 745-912 1.5e-10 36.8 In-house 54-263 (314) alignment 
Range on Protein: 745-912
Range on HMM: 54-263/314.0
EVPLLEaTRVVLkGYGKRFADDYIHASYVTYGQAFVASseYFPlKKNEICEFEGGS--------------------------------------------
...  . .||.| ..   .  |||.||||   ..|.|.   .| ... .. |.  .                                            
dilpad.nrvil.pglpvsgsdyinasyvdgflkfIat..qgp.leitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpl

--------VKCTNYEREYIgiitrkltLNFDDGEEFKI--THHQVLDWNGlNALEDHRGAGLAAMFLMK--YETTAIVHCVDGVSRSA--VLAGMIIGFQ
          .  .  ..            .|.| |.    ..  ... . .   . .    .  |. .   ..  .||| .|..|..  |.|....  .
lildgngneptaadlellk........eelydpelferlgikylripvpD.gsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll

kiietrgDMNVADLIDDLRKQRA-----MAI
       ...... ..|.|..|       .|
.......gvsleealedvrlkRpinpnpgfi
PTPc_DSPc_SM00012 861-921 2.2e-10 36.1 In-house 39-99 (105) alignment 
Range on Protein: 861-921
Range on HMM: 39-99/105.0
ETTAIVHCVDGVSRSAVLAGMIIGFQKIIETRGDMNVADLIDDLRKQRAMAITSGLELAFV
..  .||| .||.|..... . |  |.. .... ... ...  |||||. ....  .  |.
skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 785-921 1e-09 32.7 In-house 136-275 (290) alignment 
Range on Protein: 785-921
Range on HMM: 136-275/290.0
YFPLKKNEIceFEGGSVKCTNYEREYiGIITRKLTLNFDD--GEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK-----YETTAIVHCVDGVSRSAV
|.| ....   ..  |.| .| |    ..|.||| .. ..  |.. ..|..|.  |.    .... .  |.    .|      .|  .||| |.|.||||
YWpdsdtka..ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsav

LAGMIIGFQKIiETRGDMNVADLIDDLRKQRAMAITSGLELAFV
.  . .. .|  .| | ..| ...  .| |.   ...  .. ..
fcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgi
0051082 (Phosphotyrosine protein) phosphatases II 765-913 1.5e-09 33.1 In-house 3-137 (151) alignment 
Range on Protein: 765-913
Range on HMM: 3-137/151.0
DDYIHASYVTYGqaFVASSEYFPLKKNEICEFEGGSVKCTNYEREYIgiitrkLTLNFDDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY-ETT
.|||..|||| |  . .|.   .   ... |    .. . . | |.          ..   ......| ..|||   .  .    .  .  .|..  .  
sdyinfsyvtgg..lyrsggpladflellkelgiktivnlrseeerg......ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngp

AIVHCVDGVSRSAVLAGMIIGFQKiietrgdMNVADLIDDLRKQRAMAIT
 .|||  |..|...|.....  ..       ..... ....|..| ....
vlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvq
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 783-913 2.5e-09 31.2 In-house 137-267 (290) alignment 
Range on Protein: 783-913
Range on HMM: 137-267/290.0
SEYFPLKKNEICEFEGGSVKCTNYEREYIGIITRKLTL-NFDDGEEFKITHHQVLDWNGlNALEDHRGAGLAAMFLM-KYETTAIVHCVDGVSRSAVLAG
..|.| |. |.  |   .| |.. . .   || . |.. . |.| | |. |...  |   ...     | |  .. . |     .|||  |. |.  .. 
eqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpd.ksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfva

MIIGFQKIIETRgDMNVADLIDDLRKQRAMAIT
. .| | ... . .....||.  ||. |. .. 
ievglqilldGk.eldlldlvralrnsrlnsvq
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 784-914 2.5e-08 28.5 In-house 133-268 (305) alignment 
Range on Protein: 784-914
Range on HMM: 133-268/305.0
EYFPLKKNEICEFEGGSVKCTNyEREYIGIITRKLTLNF--DDGEEFKITHHQVLDWNGlNALEDHRGAGLAAMF-LMKY-----ETTAIVHCVDGVSRS
 |.| .|.|  ||.  ||. .. |... . |.|||.. .  .| |.  ....|. ||   .   .  .. |  .  ..|      ... .||| .||.|.
qYWpesktekkefgefsvelks.ektasdyieRklkisiededkesrtvlqyqltdWPd.hGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRt

AVLAGMIIGFQKIIeTRGDMNVADLIDDLRKQRAMAITS
 |   . | ....  . . ..|....  ||..|  ....
Gvfiavdialerlk.kEevvdvfevlkqlRskrmkmvqt
0046846 (Phosphotyrosine protein) phosphatases II 795-914 2.7e-08 29.3 In-house 57-158 (176) alignment 
Range on Protein: 795-914
Range on HMM: 57-158/176.0
EFEGGSVKCTNYEREYIGIITRKLTLNFDDGEEFKIthHQVLDWngLNALEDHRGAGlaamflmkyeTTAIVHCVDGVSRSAVLAGMIigfqkIIETRGD
|.| |..||.||  |. .   . | |...|.    .   ..|..  |....... .|           . .|||. |..|...|. .      ..|.. .
evelgrlkcpnywpeleklgiqylhlpwpDhgvpdl..elllel..lefirealkeg..........gpvlVHCsaGigRtgtlvaay.....llelekg

MNVADLIDDLRKQRA-MAITS
..| . .. .|.||  .|...
lsveealalvreqRplgavqt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 801-915 3.3e-08 27.9 In-house 145-264 (287) alignment 
Range on Protein: 801-915
Range on HMM: 145-264/287.0
VKCTNYErEYIGIITRKLTLNFDD--GEEFKITHHQVLDWNGLNALEDHRGAGLA--AMFLMKY---ETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRG
.. .| |  . | | ||| .. ..  |.. ... .|. .|.    .....   |    |.  ..   .|. .||| |.| |||..  . .. .|  .| |
iellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkc.kteG

DMNVADLIDDLRKQRAMAITSG
 ..| ....  | |.  ..   
viDvfqvlksqriqkpgsvqtv
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 785-922 4.1e-08 27.7 In-house 129-269 (281) alignment 
Range on Protein: 785-922
Range on HMM: 129-269/281.0
YFPlKKNEICEFEGGSVKCTNyEREYIGIITRKLTLNFDDGEEFKITHHQVLDWNGL------NALEDHRGAgLAAMFLMKYETTAIVHCVDGVSRSAVL
|.|  .|.  ..    || |. |.|    |.||..|. ..||. .... . . |         ..| ..| . .  .   | ... ..||  || |. . 
YWP.ddnselkygdvtvksta.eeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrke.vlkltekktkaplvihCsaGvGrtGty

AGMIIGFQKIIETRGDMNVADLIDDLRKQRAMAITSGLELAFVD
 ..   .... ... ...| ... .|||.| . . . .  .|| 
ialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvy
0041856 (Phosphotyrosine protein) phosphatases II 766-913 4.9e-08 28.3 In-house 20-155 (182) alignment 
Range on Protein: 766-913
Range on HMM: 20-155/182.0
DYIHASYVTYGQAF-------------------------------VASSEYFPlkkneicefeggsvkctnyereyigiitrkltlnfdDGEEFKITHHQ
|||.|...  .. .                               ...  |.|                                    . .|  .....
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywp....................................ellerlgiqyl

VLDWNGLNALEDHRGAGLAAMFLMkYETTAIVHCVDGVSRSAVLAGMIIGFQKiietrgDMNVADLIDDLRKQRAMAIT
 | | . .. . .    .  . |   . . .|||  ||.|...|... .  ..      .... . .. .|..| ....
ylpwpDhgvpdldelldfieevle.eggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklvrsrRpgmvi
0049260 (Phosphotyrosine protein) phosphatases II 796-914 5e-08 28.3 In-house 44-135 (152) alignment 
Range on Protein: 796-914
Range on HMM: 44-135/152.0
FEGGSVKCTNYEreyigiitrkltlnfddgeefkitHHQVLDWNGLNALEDHRGAGLAAMFL----MKYETTAIVHCVDGVSRSAVLAGMIIGFqkiiet
.| | .|| .|                         ... | |   .. ...     .  |.     . . . .|||. ||.|...|. . .        
lelgklkceqyi........................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......

rGDMNVADLIDDLRKQRAMAITS
  .... . .. .|..| .|...
.lgvsleeavalvrekRpgavpn
0044763 (Phosphotyrosine protein) phosphatases II 750-915 6.1e-08 28.0 In-house 3-158 (178) alignment 
Range on Protein: 750-915
Range on HMM: 3-158/178.0
EATRVVLKGYGKRFADDYIHASYVTYGqaFVASSEYFPLKKNE------------ICEFEGGSVKCTNYEREYIGiitrkltlnfddgeeFKITHHQVLD
. |||.|  .   .. |||.||... |  . ..| . .  ..               |.|.| .||  |  |  |               ..  |  . |
drtrvllsnleglersdyinaseilpg..lylgslppaddlellkelgithivnlteelelgflkcdpywpeeag...............iqylhipipD

WNGLN-ALEDHRGAGLAAMFLMKYETTAIVHCVDGVSRSAVLAGMIIGFQKiietrgDMNVADLIDDLRKQRAMAITSG
..  .     ..   .   .| . . . .|||  ||.||..|. . .  .       .... . |. .|..| . .. |
hgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielvrerRpivpnpg
0036282 (Phosphotyrosine protein) phosphatases II 795-913 6.1e-08 28.0 In-house 46-154 (174) alignment 
Range on Protein: 795-913
Range on HMM: 46-154/174.0
EFEGGSVKCTNYEREyigiitrkltlnFDDGEEFKITHHQVLDWNGLNALEDHRgAGLAAMFLMKY-----ETTAIVHCVDGVSRSAVLAGMIIGFQKII
|.| |..|| ||  |            . . .|  . ... | | . .. ...     .  |. ..     . . .|||  ||.|...|... .  . ..
ekelglykcinywpe............lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll

etRGDMNVADLIDDLRKQRAMAIT
   . ... ||.  ||.|| ....
..eslvdaldlvrelRlqrpgmvq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 818-943 6.8e-08 26.9 In-house 167-288 (307) alignment 
Range on Protein: 818-943
Range on HMM: 167-288/307.0
LTLNFDDGeEFKITHHQVLDWNGLNALEDHRGAgLAAMFLMKYETTA-IVHCVDGVSRSAVLAGMIIGFQKIIETRGDMNVADLIDDLRKQRAMAITSGL
| ... ..    |.| |  .|    . .   .| .  .  ..|.|   .|||  || ||  . .. .  .|.|.    ... .|...||.||  || . .
lkvdwaqk.srtiqhlqwenwpdrgvpqinlta.inlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqtea

ELAFVDAgifLLFKRMMNNFEEEYPED
.  ..     .|.. ... . | | | 
qylylhr...vlleyflelyketyeel
0048076 (Phosphotyrosine protein) phosphatases II 823-913 1.6e-07 26.6 In-house 40-127 (145) alignment 
Range on Protein: 823-913
Range on HMM: 40-127/145.0
DDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY---ETTAIVHCVDGVSRSAVLAGMIIGFQkiietrGDMNVADLIDDLRKQRAMAIT
 ...| ...... |.| . .. ....    .  |. ..   .   .|||  ||.|...|... . ..       .... . .. .|.|| .|..
lellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgavp
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 784-946 2.7e-07 24.5 In-house 140-299 (305) alignment 
Range on Protein: 784-946
Range on HMM: 140-299/305.0
EYFPLKKNEICEFEGGSVK-----CTNYEREYiGIITRKLTLNFDDGEEFKITHHQVLDWNGLnALEDHRGAGLAAMFLMKY-ETTAIVHCVDGVSRSAV
.|.|. . |  |. .| |      .   ||.   |    | |..  .... . | |  .|     .   . . |  .  ..  .   .|||  |. |.  
qywpaaqgeklelksgivvenvsgskpmerda.eiqitllnltysgdqkmsvrhlqwtewpdr.gvppckltslellsairgskvpivvhcsagigrtgt

LAGMIIGFQKIIETRGDMNVADLIDDLRKQRAMAITSGLELAFVdagifllFKRMMNNFEEEYPEDLKQ
.  .   ..|| | .    . .|.  || |||..| . ..  |.        . |.| | | | |    
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfi.......hrvmlnyflekykekyaa
subfamily_PTPN12_pd Subfamily PTPN12 784-940 3.1e-07 24.6 In-house 127-288 (290) alignment 
Range on Protein: 784-940
Range on HMM: 127-288/290.0
EYFPLKKNEICEFEGGSVKCTNYEREYIGIITRKLTLNFDdGEEFKITHHQVLDWNGLNALEDHRG-AGLAAM---FLMKYETTAIVHCVDGVSRSAVLA
 |.| ...| .||.  .|.... ..   ... | |..... .|. |..  .  .|   .  . .     | ..   .  . ..  .|||  || |  .. 
rYWpeegeeelefgefevtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtii

GMIIGFQKIIETRG--DMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLLFKRMMNNFEEEY
 . .  . . . .   ...| ||. .|||||| .. .     .|   .  |... ... ||..
aidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieekk
0043147 (Phosphotyrosine protein) phosphatases II 826-914 3.3e-07 25.7 In-house 61-146 (172) alignment 
Range on Protein: 826-914
Range on HMM: 61-146/172.0
EEFKITHHQVLDWNGLNALeDHRGAGLAAMFLMK-----YETTAIVHCVDGVSRSAVLAGMIIGFqkiietrGDMNVADLIDDLRKQRAMAITS
.|  . ... | |   ..  . .    .  |. .      . . .|||. ||.|...|. . .          .... . .. .|..| .|...
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqn
subfamily_egg_pd Subfamily egg 785-948 3.5e-07 24.2 In-house 126-288 (307) alignment 
Range on Protein: 785-948
Range on HMM: 126-288/307.0
YFPLKKNEICEFEGGSVKCTNYEREY----IGIITrKLTLNFDDGEEFKITHHQVlDWNGLNALedHRGagLAAM-FLMKYETTAIVHCVDGVSRSAVLA
|.|  ...   .  ||.. .|.. .     .  .| || |   | ||  . | |  |.| .. .  .    |  .  | .  . ..|....|||..|.| 
ywpkaesdslvtvpGslrienlkvdskadplfrvt.klklvGgddeerflehwqg.dvnnssdv..ysp..lrvlrklrnlskpvvvqdilGvskaatlv

GMIIGFQKIIET-RGDMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLLFKRMMNNFeEEYPEDLKQML
 . | . ...        |   .  ||..| ... | |   ||   . ..|. .. .  .|   | .. |
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa.keldvdyerwl
0048179 (Phosphotyrosine protein) phosphatases II 828-913 4.4e-07 25.3 In-house 47-129 (144) alignment 
Range on Protein: 828-913
Range on HMM: 47-129/144.0
FKITHHQVLDWNGLNALEDHRGAGLAAMFLMKY---ETTAIVHCVDGVSRSAVLAGMIIGFqkiieTRGdMNVADLIDDLRKQRAMAIT
. ..... |.| . .. ..      .  |. ..   .   .|||  ||.|...|. . . .     ..| ... . .. .|..| .|..
regiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 784-921 4.7e-07 24.1 In-house 119-262 (285) alignment 
Range on Protein: 784-921
Range on HMM: 119-262/285.0
EYFPLKKNEICEFEGGSVKCTNYEREYI-GIITRKLTL-NFDD--GEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLMK---YETTAIVHCVDGVSRSA
 |.| |  |. .|    .  |. . | | | |   ||. | .|   | . . | ||  |    | || |       .. |    |.   |||  || |.|
lyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrta

VLAGMIIGFQKIIETrGDMNVADLIDDLRKQRAMAITSGLELAFV
 . |.     .|.|   .... |.. ..|  |  |. | ... |.
tfvgidyatirimen.pniemldivremramrfqavqshmqflfl
0051429 (Phosphotyrosine protein) phosphatases II 811-928 6.6e-07 24.8 In-house 102-224 (272) alignment 
Range on Protein: 811-928
Range on HMM: 102-224/272.0
I-GIITRKLTLNFDDGEEFKITHHQVLDWNGLNALEDHRGAGLAAMFLmkyETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRGDMN--------VADLI
   . .  ||| .. || ....| . .||   .. ..   . |...     .   .|||  |..|..... ...  . . .    ..        ... .
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgv.sletivddYlltnlyleeav

DDLRKQRAMAITSGLELAFVDAGIFLL
. ||.||. |. .   ..|.   .  |
eelraqrpgavqteeqylflyeallel
subfamily_PTPN23_pd Subfamily PTPN23 783-921 1.1e-06 22.6 In-house 126-272 (288) alignment 
Range on Protein: 783-921
Range on HMM: 126-272/288.0
SEYFPLKKNEICEFEGGSVKCTNyEREYIGIITRKLTLNFDDGEEF-KITHHQVLDWNG--LNA----LEDHRGAGLA--AMFLMKYETTAIVHCVDGVS
..|.| .|.|  .|.  || . . .||    . |.|.|.. | ..  ...| |.  |    . |    | .  ..  .       | .|  .|||  || 
drYwPedkgetvkfgdlsvtlks.vretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvg

RSAVLAGMIIGFQKIIETRGDMNVADLIDDLRKQRAMAITSGLELAFV
|. |.| ..   ... .  | ... ...  ||.||   .    .| |.
RtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfs
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 781-922 1.7e-06 22.3 In-house 123-264 (288) alignment 
Range on Protein: 781-922
Range on HMM: 123-264/288.0
ASSEYFPLKKNEICEFEGGsvkCTNYEREYIGI---ITRKLTLNFDDGEEFK-ITHHQVLDWNGLNALEDHRGAgLAAMFL-MKYETTAIVHCVDGVSRS
.| ||||.|. |   .      ||   ... .|   ..  |  .   ||| . . .  .|.|.     |..    |  .    ...   .||.  || |.
ksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsp.lrllevlkslqkPivvhssaGvGrt

AVLAGMIIGFQKiIETRGDMNVADLIDDLRKQRAMAITSGLELAFVD
. |. ..|  .  .    .. .  |.  ||..|  ||..     .| 
gtlililiales.lrlddflgirsllaklreerfkaiqtemqylyvh
subfamily_Ptp69D_pd Subfamily Ptp69D 792-920 2.8e-06 21.7 In-house 141-277 (307) alignment 
Range on Protein: 792-920
Range on HMM: 141-277/307.0
EICEFEGGSVKCTNYEReYIGIITRKLTLNFDD------GEEFKITHHQVLDWNGLNALEDHRGA-GLAAMF--LMKYE-TTAIVHCVDGVSRSAVLAGM
......   ||. . |.     | |.| .   .       .. |.. .. . |.  .. |  ||   |  .   | | . .  .|||  ||.||...  .
devqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifval

IIGFQKIiETRGDMNVADLIDDLRKQRAMAITSGLELAF
 . .|.. ..   ... . . |||.|| . ..|     |
dsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 782-928 5e-06 20.5 In-house 132-280 (301) alignment 
Range on Protein: 782-928
Range on HMM: 132-280/301.0
SSEYFPLKKNEICEFEGGSVKCTNYEREYIG-IITRKLTLNfDDGEEFK---ITHHQVLDWNGLNALEDHRGAgLAAMF-LMKYETTAIVHCVDGVSRSA
 .||.|.| .|  . .  ..| .| |      |. |.| .. |  ..|.   .||.|  .|   .  . |       |  . | |   .||| .|. || 
ceeylpvkisekldigrfkikiknkelilnkkiskrtleve.dstgkfatrtvthyqysewtdrgvPkshael.fdlmelvkksekPivvhcsaGiGrsv

VLAGMIIgFQKIIETRGDMNVADLIDDLRKQRAMAITSGLELAFVDAGIFLL
 . |  . . . .|.   ..... . .||..|  ..     | ..  |    
afigtey.lareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyr
subfamily_PTPN13_pd Subfamily PTPN13 785-913 5.5e-06 20.8 In-house 122-253 (273) alignment 
Range on Protein: 785-913
Range on HMM: 122-253/273.0
YFPLKKNEICEFEG-GSVKCTNYErEYIGIITRKLTLN-FDDGEEFKITHHQVLDWNGLNALEDH--RGAGLAAMFLMKY-ETTAIVHCVDGVSRSAVLA
|.| .||.    ..   |.  ... .. |   |.|...  . ||  ...| .  .|   .           .| .  ..  ..  .|||  |. || .| 
ywPesknkklkvsnrlevellkvq.kldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtli

GMIIGfQKIIETRGDMNVADLIDDLRKQRAMAIT
 . .    .||   ...| ... .||.||   . 
tidvv.lglierdkefdvkeivrklreqrqgvvq
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 782-923 6.1e-06 20.3 In-house 129-271 (315) alignment 
Range on Protein: 782-923
Range on HMM: 129-271/315.0
SSEYFPLKKNEICEFEGGSVKCTNYEREyIGIITRKLtLNFDDGEEFKITHHQVLDWNGlNALEDHRGAGLAAMFL-----MKYETTAIVHCVDGVSRSA
   |.| .| .  ||   .|.  . |    . ..|||    .  |  ..| .|  .|   .  . . .. |  .        |.| . .|||. || |. 
crqywPdrkadsvefGsikvellslead.tdgvarkl.vtrkseesrtvtqfqftewPd.kGvdkqtssllklikevkadngkkefsllvhcsaGvGrtG

VLAGMIIGFQKIIETRgDMNVADLIDDLRKQRAMAITSGLELAFVDA
|.  .    ..| .||  ..| ...  ||..|   . .  | ||.  
vvisidevvaqikrtr.svdvfnfvknlrakrpylvqteeeyafiyd
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 799-921 6.7e-06 20.4 In-house 146-271 (288) alignment 
Range on Protein: 799-921
Range on HMM: 146-271/288.0
GSVKCTNY-EREYIGIITRKLTLNfDDGEEFKITHHQVLDWNGLNALEDHRGA-GLAAMFLMKYET---TAIVHCVDGVSRSAVLAGMIIGFQKiIETRG
|||. |   ..|   ...||| |.  ...|..||..| | |   .  |...   .|  .  .  .      |||| .|| |. .   .    .. .|.  
Gsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalida.veeed

DMNVADLIDDLRKQRAMAITSGLELAFV
 ..||. .  ||||||. .       |.
yiDvagtvaklRkqRallvqtlkqYefi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 811-913 7.1e-06 20.1 In-house 143-250 (283) alignment 
Range on Protein: 811-913
Range on HMM: 143-250/283.0
IGIITRKLTLNFD--DGEEFKITHHQVLDWnglnaLEDHRGAGLAAM---FLM------KYETTAIVHCVDGVSRSAVLAGMIIGFQKIiETRGDMNVAD
   | ..|.|. .    ... ..|.|| ||     ||   .| . ..    ..      . ..  .|||  |. |.||. ..    ...  |   ..|  
nsfiikelllrvnssakstlllahyqvidW.....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda.ltesvvdvfa

LIDDLRKQRAMAIT
 .  .|.|| ||. 
vvkimreqrmmavq
subfamily_PTPN14_pd Subfamily PTPN14 784-920 9.3e-06 19.8 In-house 137-287 (300) alignment 
Range on Protein: 784-920
Range on HMM: 137-287/300.0
EYFPLK--KNEICEFEGGSVkCTNYEREYIGIITRKLTLNF-DDGEEFKITHHQVLDWNGLNALEDHRGA-----GLAAMFLMK--------YETTAIVH
.||| .  |..  ||.   |  |.. ..   .||..|.|..   .|| .. | |  ||   .  || .|       . ..             .   .||
kyfPkleskkktvefgkfkv.ttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

CVDGVSRSAVLA--GMIIgfqKIIETRGDMNVADLIDDLRKQRAMAITSGLELAF
| .|| |. ||    ..|   . .|.  ....   .. ||.|| . . .     |
CsaGvGrtGvlilsdlli...atlehneeidikkvlarLreqrmllvqtlaqYkf