Gene R10F2.6 in Caenorhabditis elegans

Synonym: CELE_R10F2.6, R10F2.6

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf8
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP173_AA protein Get Run
CeleP173_AA_694-970 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 695-981 2e-129 425.7 In-house 19-288 (288) alignment 
Range on Protein: 695-981
Range on HMM: 19-288/288.0
E-------------SVDKIDNYIQSCCQDRWEHLYRCssprythDWARVRMSsdqpDDCDFYDACHVFPwqevfekvAHKYKNKLICASSPMyNVTVGIL
|             |.| ||..|.....||.|.|.||       |..||..|    ||.|||.|..|..        ..|||..||||..|. |.|...|
eglkkeyrdspneasidiidsfianptrdryenlprc.......ditrvkls....ddpdfyiaanvvs........sakykrrlicaqaPl.ngtieel

WHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRNayreyiveCTDVKKKYkaAGIQRLVKVTLVHNHQVIETKQ-MKILHMLEWDQDCLPE
|..|.|.||.|.|||...||||...|...||...|||||..|.        ||.||||.  |.|..||||.|.......|.|. .||||.||||.|..||
WkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl........ctvvkkkr..adidklvkvsllriskegeekvivkilhlleWdddgvPe

NWQPYVRICERMnrESLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQ-VYFWRMVHYELLFRWFKPLRELRVRM
|.....|..|..  .||..|.||.|..|.||..||||.|.|....||||.|.|.|.....|......|....| .|..|.|..|||....|.|||..|..
nylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlredfvkl

PE
.|
ae
0036941 (Phosphotyrosine protein) phosphatases II 690-967 1.7e-36 121.5 In-house 15-279 (297) alignment 
Range on Protein: 690-967
Range on HMM: 15-279/297.0
TQIAFESVDKIDNYIQSCCQDRWEHLYRC-SSPRYTHDWARVRMssdQPDDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFEN
 .  ||..... ...   .. ..|.| .. ..  . .|. ||..   .....|...|..|           ...|.| |..  |. | ||.  |....|.
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv.........dgydlkrkfIatqgPlpn.tvedFWrmvweq

DVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFrrnayREYIVECTDVKKKYKAAGIQRLVKVTLVHNHqviETKQMKILHMLEWDQDCLPENWQPYVRI
.|. .|||... |.| .  . ..|| .||   .      ...|....|......  ..| ..|| . |    |.......|.. |. ...||........
nvtvIvmltelvelgrekcaqywpleegeslty.....gdftvtllsvevvllddytlrtlevtdtgng...esrtvthfhytgwpdhgvpespaslldf

CERMNR------ESlhHPVVVMSKHGSGRAMTLILSLMAAVMAR---LDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYELLFR
.|....      ..  .||.|....| ||..|.|.  ..  . .       ..| .. .. |  . ....  .| .|.... .||| .
ielvrkvlkllpsg..gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
Y_phosphatase Protein-tyrosine phosphatase 725-961 1.6e-35 118.0 Pfam-A 13-233 (235) alignment 
Range on Protein: 725-961
Range on HMM: 13-233/235.0
HDWARVRMsSDQPDDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYnVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPlvkgeKARFRRN
 |  ||.. .......|.. | .|           .| |.|.|..  |.   |..  |.......||..|||..  ||| .. . ..|     ... . .
ydktrvkl.kgsegpsdYInAnyv.........kgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwp.....eeeeesl

AYREYIVECTdvkKK---YKAAGIQRLVKVTLVHNHQviETKQMKILHMLEWDQDCLPENWQPYVRICERMNRES--LHHPVVVMSKHGSGRAMTLILSL
 | .. ||..   .|    ... . | ....   ...  |....| ||. .| . ..||.... ...........   ..||||....|.||..|...  
tygdikvelk...ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

MAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVH
..  ... ...... ..... |........ ..| .|. .. 
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 725-961 1.6e-35 118.0 In-house 13-233 (235) alignment 
Range on Protein: 725-961
Range on HMM: 13-233/235.0
HDWARVRMsSDQPDDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYnVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPlvkgeKARFRRN
 |  ||.. .......|.. | .|           .| |.|.|..  |.   |..  |.......||..|||..  ||| .. . ..|     ... . .
ydktrvkl.kgsegpsdYInAnyv.........kgykekkkfIatQgPlk.stiedFWrmvwqekvkvivmltsleekgrekcaqYwp.....eeeeesl

AYREYIVECTdvkKK---YKAAGIQRLVKVTLVHNHQviETKQMKILHMLEWDQDCLPENWQPYVRICERMNRES--LHHPVVVMSKHGSGRAMTLILSL
 | .. ||..   .|    ... . | ....   ...  |....| ||. .| . ..||.... ...........   ..||||....|.||..|...  
tygdikvelk...ekekedekeytlrklelkkkkees..ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

MAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVH
..  ... ...... ..... |........ ..| .|. .. 
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
0050432 (Phosphotyrosine protein) phosphatases II 721-969 8.5e-33 109.4 In-house 76-303 (308) alignment 
Range on Protein: 721-969
Range on HMM: 76-303/308.0
PRYTHDWARVRMssdqPDDCDFYDACHVFPWQevfekvaHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKG-EKA
  .  |. ||..    ....|...| .|  ..       .|...| |.. .|..| ||.  |....|..|...|||... |.| .  . ..||  | .  
dilpydhsRVkl....degsdYInAsyvdgys.......sklprkfIatqgPlpn.tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsl

RFrrnayREYIVECTDVKKkyKAAGIQRLVKVTLVHNHqviETKQMKILHMLEWDQDCLPENWQPYVRICERMNRESLHHPVVVMSKHGSGRAMTLILSL
..       . |.......  ..  ..| ...| . .    |.......|.. |  .. |..........|....   ..|.||....| ||..|.|. .
ey.....gkftvtllseev..lddytvrtleltnlgdg...esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfiald

MAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYELLFRWF
..  . . .  ... .. .  |  . ....  .| .|  .. .|.|....
llleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0040438 (Phosphotyrosine protein) phosphatases II 711-968 3.9e-30 100.6 In-house 23-279 (317) alignment 
Range on Protein: 711-968
Range on HMM: 23-279/317.0
RWEHLYRCSSPRYTH------------------DWARVRMSSDQP-DDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFENDVK
 .|.|.... . |..                  |. ||..|....  |.|.. | .|           ...|.| |....|. | ||.  |. ..|..|.
efedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.........dgpnlkrkfIatqgPlpn.tvedFwrmvweqgvt

YVVMLNQFLEKGLQASEVWFPLvkGEKARFrrnayREYIVECTDVKKkykAAGIQrLVKVTLVHNhQVIETKQMKILHMLEWDQDCLPENWQPYVRICER
..|||... |.| . .. ..||  ||.  .      ...|.......    |||. | ....... .  |. .....|.. |. ...|..... ....|.
vivmLteleelgrekcaqYwpl..getlty.....gdftvtllseee...lagit.lrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldflea

MNRE--SLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYELLFRW
...   . ..||.|....| ||..|.|. ...  . .   .... .  .  |. ......  .| .|  ....|.| | 
vrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0046845 (Phosphotyrosine protein) phosphatases II 723-969 1.1e-29 99.1 In-house 38-278 (284) alignment 
Range on Protein: 723-969
Range on HMM: 38-278/284.0
YTHDWARVRMSSDQP--DDCDFYDACHVfpwqEVFEKVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVkGEKAR
.  |. ||...| ..  .|.|...| .|    ....   ...|.| |... |. | ||.  |....|..|...|||... |.| .  . ..||  ||. .
lpydhsRVklksldgdledsdYinAsyv....dgydldltyikkkfIatqgPlpn.tvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevlt

FrrnayREYIVECTDVKKkyKAAGIQRLVKVTLVH-NHqviETKQMKILHMLEWDQDCLPENWQPYVRICERMNRE----SLHHPVVVMSKHGSGRAMTL
.      ...|.......  |   ..| ...| .. .    |.......|...|  .. |.. .. ..... ...     . ..|.||....| ||..|.
y.....gdftvtllseev..kddytvrtleltnlgytg...esrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtf

ILSLMAAVMARLDD---DLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYELLFRWF
|.  ..  . . ..    ... .. .  |  . ....   | .|  .. .|.| ...
ialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0047943 (Phosphotyrosine protein) phosphatases II 722-964 7.6e-29 96.4 In-house 47-271 (273) alignment 
Range on Protein: 722-964
Range on HMM: 47-271/273.0
RYTHDWARVRMssdQPDDCDFYDACHVFPWqevfekvahKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGE-KAR
 .  |. ||..   .....|.. | .|  .         ..|.| |..  |..| ||.  |....|..|...|||... |.| .  . ..||  || . .
ilpydhsrvkl...gdggsdyinAsyvdgy.........nlkrkfiatqgPlpn.tvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelslt

FRRnayreYIVECTDVKKkyKAAGIQRLVKVTLVHNHQvieTKQMKILHMLEWDQDCLPENWQPYVRICERMNRESL----HHPVVVMSKHGSGRAMTLI
. .     ..|.......  |.  ..| ...| .....   .......|...|  .. |..... ....| ...       ..||||....| ||..|.|
ygk.....ftvtllseet..kddytvrtleltnlgtge...srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

LSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYEL
. ...  . .    ... .  .  |  .  ...  .| .|  .. .|.
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0042113 (Phosphotyrosine protein) phosphatases II 707-964 9.4e-29 96.0 In-house 3-242 (245) alignment 
Range on Protein: 707-964
Range on HMM: 3-242/245.0
CCQDRWEHLYRCSSPRYTHDWARVRMSSDQPD-DCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQ
...  . . ....|. . .|. ||..|.|..| |.|.. |..|           .....|.|... |. . ||.  |..|.|......|||... |.| .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyv.........dgyritpkfiatqgPlpe.tvedfwrmlwelgittivmLteeeelgrv

ASEVWFPLvkGEKARFRRnayreYIVECTDVKKkyKAAGIQRLVKVTLvhnHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNR---ESLHHPVV
 .. ..||  ||. .. .     ..|.......  ..  ..| ..||    ..  |...   .| | |. .. |.. .  ....|....   |. ..||.
kcaqywpl..gesltygd.....ftvtllseeh..lddytvrtlevtn...lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvl

VMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYEL
|....| ||..|.|. .... ...   ..|. .  .  |  ......  .| .| .....||
VHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0045450 (Phosphotyrosine protein) phosphatases II 700-963 2.2e-26 88.8 In-house 42-302 (307) alignment 
Range on Protein: 700-963
Range on HMM: 42-302/307.0
IDNYIQSCCQDRWEHLYRCSSPRYTHDWARVRMSSDQP--DDCDFYDACHVFPWQEVFEKVAHKyKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLN
....  |. .  . . .. ..  .  |. ||..|| ..  .|.|...| .| ..  .. .. .. |.| |.. .|. . ||   |..|.|..|...|||.
fllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpe.tvedFwrmlweqgvtvivmlt

QFLEKGLQASEVWFPLVkGEKARFRRnayreYIVECTDVKKkyKAAGIQRLVKVTLVhnHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNR---
.. |.| .    ..|.  ||.  ...     . |.......  ..  . | ..||    ..  |. . ...|...|  ...|..... ....|....   
elvelgrekcaqywPde.geeltygn.....ftvtllseeh..ldgytvrtlevtdl..dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

-ESLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDD---LSIHSMCQSGRASKRQSITCCNQVYFWRMVHYE
  . ..||.|....| ||..|.|. ... .. . .     ... .  .  |. . ....  .| .| ... .|
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 722-960 2.1e-25 85.2 In-house 58-281 (288) alignment 
Range on Protein: 722-960
Range on HMM: 58-281/288.0
RYTHDWARVRMSSDQP-DDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLvkGEKAR
 .  |. ||..|. .. ...|...| ..           ...|.| |..  |. | ||.  |....|..|...|||... |.| . .. ..||  |..  
ilpydhsRVkLsvldgvegsdYinAsyi.........dgynlkrkfIatqgPlpn.tvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggslt

FRRnayreYIVECTDVKKkyKAAGIQRLVKVTLVH-NHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNRE--SLHHPVVVMSKHGSGRAMTLIL
. .     . |.......  ..  ..| ..|| ..  ..  |... ...|.. |  .. |...............   | ..||||....| ||..|.|.
ygd.....itvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfia

SLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMV
 ...  . .    ... .. .  |  . ....  .| .|  ..
ldllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyea
0043336 (Phosphotyrosine protein) phosphatases II 694-962 1.3e-23 79.3 In-house 26-274 (278) alignment 
Range on Protein: 694-962
Range on HMM: 26-274/278.0
FESVDKIDNYIQSCCQDRWEHLYRCSSPRYTHDWARVRMSSDQPD-DCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKY
||...... . .|...    .  . ..  .  |. ||..|... | |.|.. | .|           .....| |... |. . ||.  |. ..|..|. 
feellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.........dgynvprkfiatqgPlpe.tvedFwrmvwelgvtt

VVMLNQFLEKGLQASEVWFPlvkGEKARFRRnayreYIVECTDVKKkyKAAGIQRLVKVTLVHNHQVietKQMKILHMLEWDQDCLPENWQPYVRICERM
.|||... |.| . .  ..|   |.  .. .     . |.......  ..  ..|  .||   ....   ..  ..| | |  ...||. ..........
ivmLtelvelgrvkcaqYwp...ggsltygd.....ftvtllkeeh..lddytvrtlevtnlgdges...rtvthyhylgwpdhgvpeslsllldflkav

NRE--SLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHY
..   . ..||.|....| ||..|.|. ...  ...    .....  .  |  . ....  .| .| ... .
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0040439 (Phosphotyrosine protein) phosphatases II 716-962 1.8e-21 72.3 In-house 14-243 (249) alignment 
Range on Protein: 716-962
Range on HMM: 14-243/249.0
YRCSSPRYTHDWARVRMSS-DQPDDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLv
.....  .  |. ||..|. .   ..|...| ..            ..|...|... |. . ||.  |..|.|......|||... |.| .  . ..|| 
knrypdilpydhsrvklsilpglflsdyinAsyi.........dgyyikrrfiatqgPlpe.tvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

kGEKARFrrnayREYIVECTDVKKkyKAAGIQRLVKVTLVhnhQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNRES----LHHPVVVMSKHGSG
 |.   .      .. |....|..  |.  ..| ...| .   .  |. . . .... |  . .|.. .. ....|...        ..||.|....| |
.ggsley.....gdftvtllsvev..kddytvrtleltnl...ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

RAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHY
|. |.|. ...  . .   .... .  .  |  ......  .| .|  .. .
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall
0039614 (Phosphotyrosine protein) phosphatases II 722-965 6.1e-21 70.6 In-house 65-289 (297) alignment 
Range on Protein: 722-965
Range on HMM: 65-289/297.0
RYTHDWARVRMSSDQP--DDCDFYDACHVfpwqevfeKVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLqASEVWFPLVKGeka
 .  |  ||. ..      |.|.. | .|        .. .....| |... |. . ||.  |. ..|..|...|||... |.|    .  .|   |   
ilpydhsrvklkpedgvdldsdYinAsyv........dgydlltrkfIatqgPlpe.tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...

rfrrnAYREYIVECTDVKKkyKAAGIQRLVKVTLvhNHqviETKQMKILHMLEWDQDCLPENWQPYVRICERMNRES----LHHPVVVMSKHGSGRAMTL
      | .. |....|..  ..  ..|  .||   |    |..... .. . |  .. |.. .   ...| ...       ..||.|....| ||. |.
.....tygdftvtllkveh..ldgytvrtlevtn..ng...esrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtf

ILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWRMVHYELL
|. ...  . .   .... .  .  |  ......  .| .| ... .|||
iaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045098 (Phosphotyrosine protein) phosphatases II 703-966 7.5e-19 63.6 In-house 17-273 (278) alignment 
Range on Protein: 703-966
Range on HMM: 17-273/278.0
YIQSCCQDRWEHLYRCSSP------RYTHDWARVRmssdqpddcDFYDACHVfpwqevfekvaHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVML
..... .. ...||... .       .  |. ||.         |. .| ..           . |..| |..  |. . ||   |. |.|......|||
lllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyi...........dgypkkfIatqgPlps.tvadfwrmlwelgitvivml

NQFLEKGLQASEVWFPlvKGEKARFrrnayREYIVECTDVKKKykAAGIQRLVKVT-LVHNHQVIETKQMKILHMLEWDQDCLPENW--QPYVRICERMN
....|.| .  . ..|   |.  ..      .. |......       . |  .|| | .... .|.  ...||.| |.  . |..   ..  ...|...
telvelgrekcaqywp..eggslty.....gdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefir

R---------------ESLHHPVVVMSKHGSGRAMTLILSLMAAVMArlDDDLSIHSMCQSGRASKRQ-SITCCNQVYFWRMVHYELLF
.               .. ..||.|  ..| ||. ||..  .   .   .. ... .  .  |  ... ...  .| .|  ....||| 
ealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
DSPc_SM00195 726-986 2.2e-18 61.9 In-house 39-251 (263) alignment 
Range on Protein: 726-986
Range on HMM: 39-251/263.0
DWARVRMSSDQP-DDCDFYDACHVFPWqevfekvahKYKNKLICASSPMyNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRrn
|  ||......  .. |.. | ..            ..|.| |..  |. . ||   |.  .|..||..|||... |.| .  .  .|  .|.| .|   
dhtrVklkkeekkegsdYINAnyikga.........nkkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfg..

ayrEYIVECTDVKKKYkaagIQRLVKVTLVHNHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNRESL--HHPVVVMSKHGSGRAMTLILSLMAA
   .. |....|.||      .  ...  . ...  ||.... ... .| .  .|.. .. ... . .. ..   ..|.||... | ||. |...  .. 
...kisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

VMARLDDDlsihsmcqsgraskrqsitccnqvyfwrmvhyELLFRWFKPLRELRVRMPERLEAY
   . ...                                  .| ..| ||. | .| . || |
skleeekk................................vdifeivkelRkqRpgmvqtleqY
PTPc_SM00194 726-986 2.2e-18 61.9 In-house 39-251 (263) alignment 
Range on Protein: 726-986
Range on HMM: 39-251/263.0
DWARVRMSSDQP-DDCDFYDACHVFPWqevfekvahKYKNKLICASSPMyNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRrn
|  ||......  .. |.. | ..            ..|.| |..  |. . ||   |.  .|..||..|||... |.| .  .  .|  .|.| .|   
dhtrVklkkeekkegsdYINAnyikga.........nkkkkyIatQgPl.pstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfg..

ayrEYIVECTDVKKKYkaagIQRLVKVTLVHNHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNRESL--HHPVVVMSKHGSGRAMTLILSLMAA
   .. |....|.||      .  ...  . ...  ||.... ... .| .  .|.. .. ... . .. ..   ..|.||... | ||. |...  .. 
...kisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiil

VMARLDDDlsihsmcqsgraskrqsitccnqvyfwrmvhyELLFRWFKPLRELRVRMPERLEAY
   . ...                                  .| ..| ||. | .| . || |
skleeekk................................vdifeivkelRkqRpgmvqtleqY
0037934 (Phosphotyrosine protein) phosphatases II 724-961 5.1e-18 61.0 In-house 21-238 (243) alignment 
Range on Protein: 724-961
Range on HMM: 21-238/243.0
THDWARVRMssdqpDDCDFYDACHVFPWQevfekvahkyknKLICASSPMYNvTVGI----LWHWLFENDVKYVVMLNQFLEKGLQASEVWFPlvkGEKa
. |  ||.      ...|...| ..  .             .||. . |. . ||       |. |.|......|||... |.| .  .  .|   ||. 
pydhsrvkl.....egsdyinanliyvtp............rliatqgPlpe.tveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.

rfrrnAYREYIVECTDVKKKYKaaGIQRLVKVTLvhNHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMN----------RESLHHPVVVMSKHGS
      | ...|...... . .   ..| ....        .|..   .| | |   . |.. .. ..... ..           .. ..||.|. ..| 
.....tygdftvtllseehldd..ytvrtlllen..ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRAMTLILSLMAAVMArlddDLSIHSMCQSGRASKRQ-SITCCNQVYFWRMVH
||. |||. ..   .     .... .  .  |. . . ...  .| .| ....
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeal
PTPc_DSPc_SM00012 865-962 3.8e-14 48.1 In-house 2-104 (105) alignment 
Range on Protein: 865-962
Range on HMM: 2-104/105.0
MKILHMLEWDQDCLPENWQPYVRICERMNRESL----HHPVVVMSKHGSGRAMTLILSLMAAVMARLD-DDLSIHSMCQSGRASKRQSITCCNQVYFWRM
.| .|...| . ..||.... ..... ....      ..||||....| ||. |...  ..  . .   . ..|  .... | ....... ..|. |. .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VHY
.. 
all
subfamily_PTPN3_pd Subfamily PTPN3 726-955 6.7e-13 43.2 In-house 54-265 (280) alignment 
Range on Protein: 726-955
Range on HMM: 54-265/280.0
DWARVRMSSDQPddcDFYDACHVfpwqeVFEKVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLvKGEKARfrrna
| .||.... .    |. .| .|      .|  ...  |. | .  |. . |.  .|. ..|.... .||| . .|.| .    ..|  .... .     
datrvklkeset...dyinanyv.....nmeipstglvnryiatqGPlak.tatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedele.....

YREYIVECTDVkkKYKAAGIQRLVkvtLVHNHQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMN--RESLHHPVVVMSKHGSGRAMTLILSLMAAV
| |. |.|.    . . . . | .   ......  | ...  |  |.| . ..|.. . .... ||..  |.. ..||||    | ||.  |||  .|  
ygefsvkceke..detksyvlrel...vlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala

MARLDDDLSIHSMCQSGRASKRQSITCCNQVY
.    ... .  . .  |  .   .   .|  
lieaaepvypldivrtmrdqramlvqtasqyk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 724-954 1.7e-12 42.0 In-house 58-268 (288) alignment 
Range on Protein: 724-954
Range on HMM: 58-268/288.0
THDWARVRMSS-DQPDDCDFYDACHVfpwqevfeKVaHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPlvKGEKarfr
..|  ||..   .. .. |. .| ..        .. .| |.| |.. .|. . ||.  |.  .||... .|||....|.| .  | ..|  ...|    
pyDekrvklkkleeeagaDYinasyi........dg.ekkkkkyiatqgPlad.tvndfWelvyenktstivmltelveggktkCeeYWP..dadk....

RNAYREYIVECTDVKKKYKAagIQRLVKVTlvhnhQVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNRESLH--HPVVVMSKHGSGRAMTLILSLM
 . | .  |. ...|.. .   ..| . .      .  .  ... .. | | ..  ||. .| . . . ..  .     |..|    | ||. | |   .
pknyGsvtvtlveskeledf..vlrkllle.....kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialda

AAVMARLDDDLSIHSMCQSGRASKRQSITCCNQV
.  . . .| . . .. .  | .. . .   .| 
lidaveeedyiDvagtvaklRkqRallvqtlkqY
0041856 (Phosphotyrosine protein) phosphatases II 763-965 4.6e-12 41.4 In-house 33-171 (182) alignment 
Range on Protein: 763-965
Range on HMM: 33-171/182.0
KNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNqflekglqaSEVWFPlvkgekarfrrnayreyivecT-Dvkkkykaagiqrlvkvtlvhnhqvie
 .. |..  |... ||   ...| |......|.|.         .|  .|                     .                            
atrfiatqgplls.tvadflrmlkelgittivnlt.........eelywp.....................ell..........................

TKQMKILHMLEWDQDCLPEnWQPYVRICERMNResLHHPVVVMSKHGSGRAMTLILSLMAAVMarlddDLSIHSMCQSGRASKRQSITCCNQVYFWRMVH
...   .. | |. .. |. ..  ....|....   ..||.|  ..| ||. ||..  .  ..     ..|. .  .  |  . ..... || .| ... 
erlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlal

YELL
.|||
lell
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 723-956 9.5e-12 39.8 In-house 62-281 (298) alignment 
Range on Protein: 723-956
Range on HMM: 62-281/298.0
Y----THDWARVRMSS-DQPDDCDFYDACHVFpwqevfekvAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGE
|    . | .||.... |. ...|.  | ..          |.| .|  | .  |. . ||   |. . |.|.. .|||..  |..    . ..| .. |
yadiialdssRvvLekedadeesdYiNAsflh.........aykgrnafiatqaPlte.tvedFWrmvteedigtiVmltnleeldktkyhkywPdegke

KarfrrnaYREYIVectDVKKKYKAAGIQRlVKVTlVHNHQVIETKQMKILHMLEWDQDCLPENWQPYVRICER---MNRESLHHPVVVMSKHGSGRAMT
.       | |  |   ....|.. | .   .|.. |..... ...... ||. .| . . ||| .  . . ..   ..... ..||.|   .| ||. |
t.......ygeitv...sllskeefadliv.rklk.vskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGt

LILslMAAVMARLDD--DLSIHSMCQSGRASKRQSITCCNQVYF
 |   . .|. |.     . .. . .  |... ....  .|  |
fia..idsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvf
0036282 (Phosphotyrosine protein) phosphatases II 763-954 3.4e-11 38.6 In-house 16-159 (174) alignment 
Range on Protein: 763-954
Range on HMM: 16-159/174.0
KNKLICASSPMYnvtvgiLWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLvkgekarfrrnayreyivectdvkkkykaagiqrlvkvtlvhnHQVIET
 ..||. . |.        |..|.|.....||||..  |.||     ..|                                            ..  ..
tprliagqgpla......fwemlkelgittvvmlleekelglykcinywpe...........................................lredle

KQMKILHMLEWDQDCLPENWQpYVRICERMNRES---LHHPVVVMSKHGSGRAMTLILSLMAAVMARlDDDLSIHSMCQSGRASKRQSITCCNQV
.    .. | |. .. |.  .   ........      ..||.|  ..| ||. ||.. ..  .. .  .   . .. .. |  . ....  .| 
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy
subfamily_PTPN14_pd Subfamily PTPN14 727-956 3.5e-11 37.6 In-house 63-287 (300) alignment 
Range on Protein: 727-956
Range on HMM: 63-287/300.0
WARVRMSSDQPDDCDFYDACHVfpwqevFEKVAHKyKNKLICASSPMyNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKarfRRNAY
 .||..|. . .. .. .| ..         |. | . . | | .|. . || . |. ..|..|. .||| .  |.| . |  .||  . .|   ..  .
dnrvelsptkenstgyinassi......kvsvggk.ersyivaqgPl.eltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskk...ktvef

REYIVECTDVKKKYKAagIQRLVKVTLVHNHqviETKQMKILHMLEWDQDCLPENWQPYVRICE-------RMNRES----LHHPVVVMSKHGSGRAMTL
 .. |    ...  .   | . .|.  .  .   | ... .|   .| .. .||. ....   |       ..|.|.     . ||.|    | ||.  |
gkfkvttkfsedsdsv..ittglklkhlpsk...eertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvl

ILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYF
||| .       .... |... .  |  .   .    |  |
ilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkf
subfamily_egg_pd Subfamily egg 763-962 7.9e-11 36.2 In-house 82-268 (307) alignment 
Range on Protein: 763-962
Range on HMM: 82-268/307.0
KNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKglQASEVWFPLVKGEKARFRRNAYReyiVECTDVKKKykAAGIQRLVKVTLVHNHqviet
 |..|.| .|. | ||  .|  .|...|.|.|||.   |   .  | ..|  . . ...   ..|   .|. .|..|  |  . |. |. ||  .     
lnefilaqaplkn.tvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslr...ienlkvdsk..adplfrvtklklvGgd.....

KQMKILHMLEWDQDCLPENWQPYvRICeRMNREsLHHPVVVMSKHGSGRAMTLIlSLMAAVMARLDD---DLSIHSMCQSGRASKRQSITCCNQ-VYFWR
.. . |   ..| . . . . |. |.  |. |. | .|||| .. |  .| ||. ..  |..  |        .   ..  |  .| |. .  . .. .|
deerflehwqgdvnnssdvyspl.rvl.rklrn.lskpvvvqdilGvskaatlv.aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyr

MVHY
.| .
lvlf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 758-963 2.1e-10 35.0 In-house 69-268 (285) alignment 
Range on Protein: 758-963
Range on HMM: 69-268/285.0
VAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRnayreYIVECTDVKKKYKAAGIQRLVKVTLVHNh
.  | ..  | .  |. . |.  .|| .... . ||.||  ..| |..   ...|   ||  .| .     | .  |..|..  |  |   . |.   . 
mpgkdqstyittqgplpe.tlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgk.....yeitlteckeeaiagtilnaltvinted.

QVIETKQMKILHMLEWDQDCLPENWQPYVRICERMNR-ESLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYF
   |   |. ...  | ..  ||. .| . . . ... .   .|..|    | ||. |..    |..    . .. .  . .  || . |..    |. |
asseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflf

WRMVHYE
  .|  |
lyvvlme
subfamily_PTPN1_pd Subfamily PTPN1 761-929 5e-10 33.5 In-house 68-230 (290) alignment 
Range on Protein: 761-929
Range on HMM: 68-230/290.0
KYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKG-EKARFRRNAYREYIVEcTDVKKKYKaagiqrlVKVTLVHNHQV
. | . | .  |. | ||. .|. ..|.. | |||||...||. .    ..|  .  ..  .    ..  ... ...|..|.       |..  ..| . 
eakrsyiltqGPlpn.tvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklis.eerksyyt.......vrllelenlkt

IETKQMKILHMLEWDQDCLPENWQPYVRICERMNRE----SLHHPVVVMSKHGSGRAMTLILslMAAVMARLDD
 ||...   | . |    .||  . ...   .. .     | . |.|.    | ||. |..|  . ........
qetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfcl..vdtclvliek
subfamily_PTPN23_pd Subfamily PTPN23 725-924 9.3e-10 32.8 In-house 55-238 (288) alignment 
Range on Protein: 725-924
Range on HMM: 55-238/288.0
HDWARVRMSSDQpDdcDFYDACHVfpwqevfEKVaHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRn
.| .|| . . . |  |. .|..|       ...   .  ..|.. .|. . |..  |  ..|. .. .||| .  |.| .  . ..|  |||  .|   
yDhnRvklrgsk.D..DYinAsfv.......kdl.spgcPdfiatqaPlqs.tlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.

ayreYIVECTDVKKkyKAAGIQRLVKVTLVHNHqviETKQMKILHMLEWDQDCLPENW------QPYVRICERMNRESLHHPVVVMSKHGSGRAMTLILS
    . | . .|..      ..| .|..  ...   ..|... |.. .| .  .|.           |. . . ... .. |.||    |.||. .. | 
....lsvtlksvre..tethvervlkletldad...avksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalv

LMAAVM
  |.  
yaavre
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 726-960 1.8e-09 32.2 In-house 22-237 (250) alignment 
Range on Protein: 726-960
Range on HMM: 22-237/250.0
DWARVRMSSDQ-PDDCDFYDACHVfpwqEVFEKvahkyKNKLICASSPMYNVTVGiLWHWLFENDVKYVVMLNQFLEKGLQaSEVWFPLvkgEKARfrrn
| .|| . ...  ...|. .| ..    .....     ..  | . .|. . ... .|  ..|.... .|||... |.. .  . ..|    |||.    
dssrvvLekekgdkesdyinasfl....hgyde.....rkafiatqgPlqatied.fWrmvleeksgtivmLtnLkesekt.yhqywPv...ekae....

AYREYIVECTdvKKKYKAAGIQRLVKVTLVHNHqviETKQMKILHMLEWDQDCLPENWQPYVRICERMNRESLH---HPVVVMSKHGSGRAMTLILslMA
 | .  |.    .|. .|  ..| .|..  ..    . .... || . |   . ||. .  . . ......  .    ||.|    | ||. . |   . 
kyGdvtvsll..skeefadytkrklklskakka...derivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafia..id

AVMARL--DDDLSIHSMCQSGRASKRQSITCCNQVYFWRMV
||. ||  .  . .. . .  |. . ....  .|  |  ..
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyei
0043147 (Phosphotyrosine protein) phosphatases II 763-960 1.8e-09 33.1 In-house 19-156 (172) alignment 
Range on Protein: 763-960
Range on HMM: 19-156/172.0
KNKLICASSPmYNVTVGILWHWLFENDVKYVVMLNQFlekglqasevwfplvkgekarfrrnayreyivectdvkkkykaagiqrlvkvtlvHNHQVIET
 ...|.   | .. |.   |. | |......|.|...                                                        .    ..
pdrfiatqgp.lrntladfwrmlkelgithivnltel.......................................................lydpelle

KQMKILHMLEWDQDCLPeNWQPYVRICERMNR---ESLHHPVVVMSKHGSGRAMTLILSLMAAvmarldDDLSIHSMCQSGRASKRQSITCCNQVYFWRM
..   .. | |.  . | . .   ...| ...   .| ..||.|  ..| ||. ||.. ..         .||..   .  |. ......  .| .| ..
rlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyrflyy

V
 
f
0049260 (Phosphotyrosine protein) phosphatases II 769-956 2.1e-09 32.7 In-house 13-141 (152) alignment 
Range on Protein: 769-956
Range on HMM: 13-141/152.0
ASSPMYNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFplvkgekarfrrnayreyivectdvkkkykaagiqrlvkvtlvhnhqvietkqmkIL
|   ... |.   |..| |......|||...||.|    | ..                                                         
atqgpgpntladfwrmlkelgittivmltellelgklkceqyi.......................................................qy

HMLEWDQDCLPENWQPYVRICERMNR--ESLHHPVVVMSKHGSGRAMTLILSLMAAvmarldDDLSIHSMCQSGRASKRQSITCCNQVYF
. | |. .. |.. |    ... ...  .. ..||.|  ..| ||. ||.. ..         ..|.    .  |. . ....  .| .|
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 763-958 2.6e-09 31.3 In-house 89-274 (301) alignment 
Range on Protein: 763-958
Range on HMM: 89-274/301.0
KNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRnayreYIVECTDVKKKYKAAGIQRLVKVTlvHNHQVIET
 ...|.. .|. | |   .|  |   ||. .||| |..||  .  | ..|.  .|| .  |     . .. .. ..  .   ..| ..|.     . ..|
phrfiatqgPlkn.tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr.....fkikiknkelilnkkiskrtleve..dstgkfat

KQMKILHMLEWDQDCLPENWQPYVRICErMNRESlHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVYFWR
. .      || .  .|.       . | . ..| ..|.||    | ||....| . . |     |  . .    .  |  . ...   .|.|. .
rtvthyqysewtdrgvPkshaelfdlme.lvkks.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmt
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 767-953 3.3e-09 30.8 In-house 97-271 (290) alignment 
Range on Protein: 767-953
Range on HMM: 97-271/290.0
ICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFrrnayREYIVECTDVKKKYkAAGIQRLVKvtlVHNHQVIETKQMK
| .  .. . ||  .|  . ...| ..||| . .|.|    | ..|  .||   |      |. | |.  ..|  |  |....    | . .    ...|
iltqGalkd.tvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltf.....Geitvlcseeddkd.aniikktls...vrdkdsGkehklk

ILHMLEWDQDCLPENWQPYVRICERMNResLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQ
 |..  | . ...      .|.   . .  .  ||||    | ||. |..   ... .     .| .  .... | |. .|.    |
hlkikswpdksvalstlallrtlrilrk..asGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 764-917 6.9e-09 29.8 In-house 88-238 (305) alignment 
Range on Protein: 764-917
Range on HMM: 88-238/305.0
NKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRNAYREYIVECTDVKKKYKAAGIQRLVKVTLVHNHQVIETK
...||. .|. . |   .|.  ... |... || ..|||| .    .|.  ....  |. .  .  .   . |. |...    .. .  || .    ...
krfictqaplek.tcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekar

QMKILHMLEWDQDCLPENWQPYVRICERMnrESLHHPVVVMSKHGSGRAMTLIL
...  |  .| .  .|   .  . . |.    ... |.||    | ||. ....
kvthyhwidwpdrgvpaadlailelleka..rpskgpivvhcsagigrtgsvvm
0046846 (Phosphotyrosine protein) phosphatases II 765-964 7.1e-09 31.2 In-house 24-172 (176) alignment 
Range on Protein: 765-964
Range on HMM: 24-172/176.0
KLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKArfrrnayreyivectdvkkkykaagiqrlvkvtlvhnhqvietkq
. |.   |... |.   ...|.|.....||.|..  |.|      ..|......                                              
rpiatqgplpr.tladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................................

mkILHMLEWDQDCLPENwQPYVRICERMNRESLHH-PVVVMSKHGSGRAMTLILSLmaavMARLDDDLSIHSMCQSGRASKR-QSITCCNQVYFWRMVHY
    . | |.  . |.  .   ...| ...   .. ||.|  ..| ||. ||.. .    . .|. .||..   .  |. .. ....  .|..| .....
..qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyefel

EL
.|
ll
0051429 (Phosphotyrosine protein) phosphatases II 763-967 8.8e-09 30.9 In-house 21-227 (272) alignment 
Range on Protein: 763-967
Range on HMM: 21-227/272.0
KNKLICASSPMYNvTVGILWHWlFENDVKYVVMLNQFLEKGLQA-SEVWfP--------LVKGEKARFRRNAYREYIVECTDVKKkykaagiQRLVKVTL
...|.... |. . |.  .|..  |...|..|.| .  |.| .  . .| |        ..  .  . . .|.| ......             | . .|
pgrlyrsggplpl.taadfwrl.kelgiktivdLrseeErgrlkcdryw.pgirylhlpilddsaptilygalrvtllseellld.......yilrelll

VHNHQVIETKQMKILHMLEWDQDCLPENWqpYVRICERMNReslHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLS--------IHSMCQSGRASKR
.. ..  |. .. .||.. |  .. |...  .... | ...   ..||.|  ..| .|  |... |. .    |.. .         .    .  ||  .
tlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrp

QSITCCNQVYFWRMVHYELLFR
...    |..| ...  ||| .
gavqteeqylflyeallellrs
subfamily_PTPN13_pd Subfamily PTPN13 762-957 1.4e-08 29.4 In-house 75-261 (273) alignment 
Range on Protein: 762-957
Range on HMM: 75-261/273.0
YKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRrNAyreYIVECTDVKKkYKAAGIQRLvkvtLVHNHQVIE
 . . | .  |. . ||  .|  ..| ... ..|. .  |||    . ..|  |..|   . |    . ||  .|.| ...  ...|     |.. .  |
deyeyiacqGPlPe.tvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvs.nr...levellkvqk.ldgfvvral....avkdsesge

TKQMKILHMLEWDQDCLPENWQPYVRICERMNRESL-HHPVVVMSKHGSGRAMTLILSLM-AAVMARlDDDLSIHSMCQSGRASKRQSITCCNQVYFW
....  |.. .|     | . .. ...  ...|    . |.||    | ||. |||   .   ...| | .. .. . .. |  ..  .   .|  | 
srevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglier.dkefdvkeivrklreqrqgvvqtkdqyifv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 761-956 1.9e-08 28.7 In-house 24-212 (255) alignment 
Range on Protein: 761-956
Range on HMM: 24-212/255.0
KYKNKLICASSPMYNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRrnayrEYIVECTDvkkkYKAAGIQRLVKVTLVHNHqVI
..| .       .| .||  ... .  .. . ||||  | |.| .  . .||| | || ..      .  | .|.      |  . | ...|.   .   
hvkPekdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkla.....dvnvtttk....ssadvvlrtleitstlge.kk

ETKQMKILHMLEWDQDCLPENWQPYVRIcERMNRESlhHPVVVMSKHGSGRAMTLILS--LMAAVMARLDD----DLSIHSMCQSGRASKRQSITCCNQV
.|...|  .   | .   ||. .    |  .. |.|  ..|||.   | ||. ...|   .   ..  ||     .|   |. .  | .....|    |.
kthtvkhysykGWieknaPelareilni.lkvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql

YF
 |
af
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 764-954 2.2e-08 28.5 In-house 82-266 (307) alignment 
Range on Protein: 764-954
Range on HMM: 82-266/307.0
NKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRNAYReYIVECTDVKkkyKAAGIQRLVKVTLVHNHQVIETK
.|.|||  |. | |.  .|    ...|. |.|| . .| .    | ..||..|.|  |  ..     |.   .|   | |  . |..|| ..     ...
kkficaqgplen.tqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapnt.isvanlgak...klapdedlinvttlkvdwaqksr

QMKILHMLEWDQDCLPENWQPYVRICERMNREslHHPVVVMSKHGSGRAMTLI-LSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQV
 .. |   .| .   |.     . . | .. .  . ||||    | ||. |.. .||.   | .  .  ... . .  |. .. .|    | 
tiqhlqwenwpdrgvpqinltainlleavryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 710-953 6.1e-08 27.1 In-house 39-264 (281) alignment 
Range on Protein: 710-953
Range on HMM: 39-264/281.0
DRWEHLYRCSSpRYTHDWARVRMS-SDQPDDCDFYDACHVfpwqevfekVAHKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASE
|   .  | |     .| .||... ...  ..|. .| .|          . | ... | . .|. . .. . |. ..|..|. .||. . .|.|     
denvlknrYsn.ivaYDatrvkvtpneenkntDYinanfv.........pgykgekeyiatqgPvPa.slvafWqmvweqkvsaivmvtreieagklkCh

VWFPlvKGEKarfrRNAYREYIVECTDVKKkyKAAGIQRLVKVtlvhNHQVIETKQMKILHMLEWDQDCLPENWQPYVR---ICERMNRESLHHPVVVMS
 ..|   ...    .  | ...|. |  ..  ||  |.| .|.    ...  ||.... |. . | .   |.. .  .      ....... ..|.|.  
rYWP..ddns....elkygdvtvkstaeee..katyierkfkl....eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihC

KHGSGRAMTLI-LSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQ
  | ||. | | |  ..  ...   .|... . .. | ..   .    |
saGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvq
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 760-958 8.5e-08 26.5 In-house 88-272 (315) alignment 
Range on Protein: 760-958
Range on HMM: 88-272/315.0
HKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVkgekarfrRNAYREYIVECTDVkKKYKAAGIQRLvkvTLVHNHQV
...|.. |.| .|  . .|. .|  .||.|.  .|||..  |.  . .| ..|          .  | .. |   .  ....   .. |   . | . ..
ynkkrryiaaqgpnva.svkdfwrlvfeedigkivmltnlvegekrkaekywpdk........kviyGkitvtrkse.evnteytvrtl...svvfgdni

IETKQmkiLHMLEWDQDCLPENWQPYVRICE---RMNRESLhHPVVVMSKHGSGRAMTLIlSLmAAVMARL--DDDLSIHSMCQSGRASKRQSITCCNQV
 |  |   ||.  | .  .|.   |.. .     . . .|   ..||  . | ||. |.| .|  ||. ..  .. . .. ...  |. ... .   .| 
revvq...lhytswpdmgvpkytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfi.tl.davldqaeaenaidvynfitgvrqnrikmvqvaeqy

YFWR
 |  
qfiy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 763-944 1.3e-07 25.6 In-house 95-265 (305) alignment 
Range on Protein: 763-944
Range on HMM: 95-265/305.0
KNKLICASSPMyNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRRNAYREYIVECtdvKKKYKAAGIQrLVKVTLVHnhQVIET
....|||  |. . |.  .|  . .| |. .||| . .| |      ..|. .|||  ..     | .  .   |   . | || .  . | .     ..
ekrficaqgpl.dqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgs...kpmerdaeiq.itllnlty..sgdqk

KQMKILHMLEWDQDCLPENWQPYVRICERMnRESlHHPVVVMSKHGSGRAMTLILslMAAVMARLDDDLSIHSMCQSGRASK
  .. |.  || .  .|      . .   . | | . |.||    | ||. |..   .  .. .. .. .   | .  .| .
msvrhlqwtewpdrgvppckltslellsai.rgs.kvpivvhcsagigrtgtiva..ieyilekiaenkpcppmpelvkalr
subfamily_PTPRB_pd Subfamily PTPRB 760-948 2e-07 25.3 In-house 90-268 (293) alignment 
Range on Protein: 760-948
Range on HMM: 90-268/293.0
HKYKNKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVkgekarfrR--NAYREYIVECTDvkKKYKAAGIQRLVKVTLvhnh
.. ... | .  |. . ||  .|. ..|. .. .||| | .||| .  | ..|          .   .| .  |. .   .. .   . | .|..     
ynsprefiatqGPlpe.tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad........eepvlyGdikvtlva..eeeledwvirelkiek....

qVIETKQMKILHMLEWDQDCLPENWQPYVRICERMN----RESLHHPVVVMSKHGSGRAMTLILS--LMAAVMArlDDDLSIHSMCQSGRASKRQSI
   |..... .| . | .   ||. .. ........    ... ..|.||    | ||. |.|    |. |.    .| . | .. .. | .. . .
.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllv
subfamily_hpo-7_pd Subfamily hpo-7 776-925 3.6e-07 24.4 In-house 45-183 (263) alignment 
Range on Protein: 776-925
Range on HMM: 45-183/263.0
VTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFRrnayrEYIVECTDVKKkykaAGIQRLVKVTLVHNHqVIETKQMKILHMLEWDQ
 |.  ... .  .  . ||||  | |.| .  . .||| | || ..      .  | .|.|..      . .  ... . ..  ..|...|      | .
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqkla.....nvnvcttkvqs....dvllktlellstlge.KkkthtvkhysykgWie

DCLPENWQPYVRICeRMNRESlhHPVVVMSKHGSGRAMT--LILSLMAAVMA
   ||. .  ..|  ...|.|  ...||.   | ||.    .. ..   .. 
kndpelareilnil.kvarns..kslvvhcstGiGrsaafsvaElvyqkmir
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 726-892 4.5e-07 24.0 In-house 46-193 (297) alignment 
Range on Protein: 726-892
Range on HMM: 46-193/297.0
DWARVRMSSDqPDDCDFYDACHVfpwqeVFEKVAHKYknKLICASSPMyNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGEKARFrRNA
| .||..    . . |. .| .|     || .  ...  | |.|  |. . ||   |. ..|.||. .||. .. | | .    ..| |..|. .   . 
ddtrvkllrv.iterdyinadyv.....vfpdeeadl..kyilaqGpl.satvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlka.gdv

YREYIVECTDvkkKYKAAGIqrlVKVTLVHNhqvIETKQMKILHMLEWDQDCLPENWQPYVRICERM
  |.. . .|   ...   .    ...|..     |.....    | | .  .| . .  ||   ..
vveflsstsd...efdrvil...telqliyr...sesrvvrhvqflswpdhGvpsdledlvrfqaqv
0051082 (Phosphotyrosine protein) phosphatases II 766-957 4.9e-07 25.0 In-house 15-145 (151) alignment 
Range on Protein: 766-957
Range on HMM: 15-145/151.0
LICASSPMYnvtvgILWHWLFENDVKYVVMLNQFLEKGlqASEVWFPLVKgekarfrrnayreyivectdvkkkykaagiqrlvkvtlvhnhqvietKQM
|.. . |.        . .| |...|..|.|..  | |      ..|                                                   . 
lyrsggpla.....dflellkelgiktivnlrseeerg..ycpeylpelg...............................................iev

KILHMLEWDQDCLPENWQPYVRICERMNReSLHHPVVVMSKHGSGRAMTLILSLMAAVMarldddLSIHSMCQSGRASKRQSITCCNQVYFW
. ...| |.   ||.... .... | ...   ..||.|  ..| ||  ||.. .. . .      .|. .  .  |..   ...  .| .|.
lhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq
0049772 (Phosphotyrosine protein) phosphatases II 762-921 1.1e-06 24.1 In-house 83-236 (314) alignment 
Range on Protein: 762-921
Range on HMM: 83-236/314.0
YkNKLICASSPMYNVTVGI---------LWHWLF--ENDVKYVVM---------------------LNQFLEKGlqasevwfplvkgekarfrrnayR--
. .| |... |. .. | .          |.  .  ...| ..||                     |... ..|                          
f.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......................nep

-----EYIVectdvkkkykaagiqrlvkvTLVHNHQVIETKQMKILHMlEWDQDCLP--ENWQPYVRICERMnreSLHHPVVVMSKHGSGRAMT-LILSL
     |..                     . .....  |   .| |..  .. .. |  | ..  ....|.    . ..||.|  |.| ||. | ... .
taadlellk....................eelydpelferlgikylri.pvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaay

MA
. 
lm
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 858-956 1.3e-06 22.1 In-house 176-276 (302) alignment 
Range on Protein: 858-956
Range on HMM: 176-276/302.0
QVIETKQMKILHMLEWDQDCLPENWQPYVRICERM--NRESLHHPVVVMSKHGSGRAMTLILSLMAAVMARLDDDLSIHSMCQSGRASKRQSITCCNQVY
 . ..  ... ..  | |.  |..    ..  . .  . ..  ...|..||.|.||| ...   .|      ...  |. . .| |. . ...  ..|  
gcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyv

F
.
s
0044763 (Phosphotyrosine protein) phosphatases II 766-922 1.7e-06 23.3 In-house 30-135 (178) alignment 
Range on Protein: 766-922
Range on HMM: 30-135/178.0
LICASSPMynvtvGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPLVKGekarfrrnayreyivectdvkkkykaagiqrlvkvtlvhnhqvietkqm
|. .| |.        . .| |......|.|.. || | . .  ..|   |                                                 
lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................................................

KILHMLEWDQDCLPENWQPYVRICERMNRE--SLHHPVVVMSKHGSGRAMTLILS-LMAA
   . . .. .. |.  .   ...| ...   . ..||.|  ..| ||. ||..  ||  
iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkk
subfamily_PTPRN_pd Subfamily PTPRN 766-933 2.1e-06 21.6 In-house 102-260 (297) alignment 
Range on Protein: 766-933
Range on HMM: 102-260/297.0
LICASSPMyNVTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPlVKGEkarfrrNAYREYIVECtdVKKKYKAAgiQRLVKVTLVHNHQVIETKQM
 | . .|. . ||  .|  ..|. |  .|.| .  |.|... . ..|  .|.      . |  | |.   | ..  .   . ||.   . | |  ||. .
yiatqgpl.astvadfwqmvweqGvvvivnltrleeegvkqckrywp.deGs......evyhiyevhl..vsehiwcd..dylvrsfylknlqtsetrtv

KILHMLEWDQDCLPENWQPYVRICERMNRE--SLHHPVVVMSKHGSGRAMTLIL-SLMAAVMARLDDDLSI
  .| | | .   | . .. .    ..|.       |.|| . .|.||. . ||  |. . ...   .. |
tqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 764-920 5.2e-06 20.7 In-house 73-223 (274) alignment 
Range on Protein: 764-920
Range on HMM: 73-223/274.0
NKLICASSPMYNvTVGILWHWLFENDVKYVVMLNQFLEKGLQASEVWFPlvkgEKARF-RRNAYREYIVECTDVKKKYKaagiQRLVKVTLvhnHQVIET
.  . .  |. | ||  .|. .....|. .||| .. |.  |  .|.||    ..  .   . | .  .. ...... .     .. |..|   ......
kayvatqGPlpn.tvadfWrmiyqeevqvivmltklkeaneqkCavyfP....daedyeiserygdveikvekivernd....ysvrklvl...kylere

KQMKILHMLEWDQDCLPENWQPYVRICERMNR---ESLH--HPVVVMSKHGSGRAMTLILSLM
...|     .|     |.. .. ..... ...   |. .   ||||    | ||.   |  ..
rsvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisi