Gene R155.3 in Caenorhabditis elegans

Synonym: CELE_R155.3, R155.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP175_AA protein Get Run
CeleP175_AA_803-1057 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 802-1109 4.7e-132 434.5 In-house 13-290 (290) alignment
Range on Protein: 802-1109
Range on HMM: 13-290/290.0
REALKSEQMKQRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCSHGLQLILSQAPQEANGESCESTIESYWWTAKQEKSTQLVMMCDFDEKCPGKTN-S
 . .|...|.|||..|||..||||||.||. |||||||||||||..||.|||.|.|||...|...||||..||.|||||..|.||.|.|.||...... .
tdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfa

CARYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVKFDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMI
||.|.||||||..|||.|||.||||..|.|.|||||.||||..|..|||||.|.|||.||||.||....|||||.|.|.|||.|||.||||||||.|..|
CakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii

IGYQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVkllglfvdaqqnkgeltreqcILAQQELMRFYTSCPEaqkwfswpqkQQAKTGEKR
.|||..... ||||||.|....|.|||.||||||||||||||||                     .||...|..|.....|          ..||..||.
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.....................llaievldqfaeeete..........kkakaeeke

TYKKIKQLK
|||||||||
tykkikqlk

0040438 (Phosphotyrosine protein) phosphatases II 809-1108 2.4e-51 170.3 In-house 45-311 (317) alignment
Range on Protein: 809-1108
Range on HMM: 45-311/317.0
QMKQRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCSH-GLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPE
.. .   |..  ..||.|...|  ...|||.|. |.. . . . |. |.|.       ..|.|..|.  .....| .||.....|    . . ||.|.|.
dknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl.......pntvedFwrmvweqgvtvivmLtelee...lgrekcaqYwpl

svGESMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAFASMIIG
  ||.......||...| . ..... |.|||.  .. |..||||    ||   .| |.. |. .........     .||.||| .|..|...|. . . 
..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylm

YQLVIQSLgSVKLEAVVSYIRSQRAMAITSALELAFVdagivkllglfvdaqqnkgeltreqcILAQQELMRFYTSCPEAQKWFSWPQKQQAKTGEKRTY
.... .    | .| .| ..|.||..|...   . |.                          . | .|.....  ...|........|....   .. .
leqlekeg.gvdveeavkelreqRpgavqtpeqyrfl..........................ydalleylkrkltlepaselklkllklliplalddvk

KKIKQL
 |.|.|
lkekel

DSPc_SM00195 804-1045 2.5e-49 163.3 In-house 23-260 (263) alignment
Range on Protein: 804-1045
Range on HMM: 23-260/263.0
ALKSEQMKQRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCS-HGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCA
  |......   |.....||| ||.  .  ..|||.|| .... .  . |. |.|.       .||.|..|..  .||... ||.....|.   . . |.
kkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeen...gkekcd

RYYPESVGESMKFKNLTVECKSKIAEK-DFETRELEVKFDG-HEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAF
||.||. |....|....|...... .| ....|.||....| .|...||.    .|.  .|. .|  ...|....|.|    ..|..||| .|..|...|
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

ASMIIGYQLVIQSLGsVKLEAVVSYIRSQRAMAITSALELAFVDAGIVK
... | .. . .    |.....|. .|.||......  ...|.   |..
vtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 804-1045 2.5e-49 163.3 In-house 23-260 (263) alignment
Range on Protein: 804-1045
Range on HMM: 23-260/263.0
ALKSEQMKQRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCS-HGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCA
  |......   |.....||| ||.  .  ..|||.|| .... .  . |. |.|.       .||.|..|..  .||... ||.....|.   . . |.
kkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl.......pstvedFWrmvweekvkiivmlteeeen...gkekcd

RYYPESVGESMKFKNLTVECKSKIAEK-DFETRELEVKFDG-HEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAF
||.||. |....|....|...... .| ....|.||....| .|...||.    .|.  .|. .|  ...|....|.|    ..|..||| .|..|...|
rywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

ASMIIGYQLVIQSLGsVKLEAVVSYIRSQRAMAITSALELAFVDAGIVK
... | .. . .    |.....|. .|.||......  ...|.   |..
vtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaile

0036941 (Phosphotyrosine protein) phosphatases II 810-1040 2.1e-47 157.2 In-house 42-270 (297) alignment
Range on Protein: 810-1040
Range on HMM: 42-270/297.0
MKQRLPIPLVMDTRVVLKDygtlFNDDYIHANRVTCSH-GLQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPES
. .   |.   .|||.|.|     ..|||.|. |.. . . . |. |.|..       .|.|..|.   ....| .||.....|.     . ||.|.|. 
knRykdilpydhtRVkldd....egsdYinAsyvdgydlkrkfIatqgPlp.......ntvedFWrmvweqnvtvIvmltelvel...grekcaqywple

VGESMKFKNLTVECKSKIA--EKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN------STTPVMVHCIDGISRSAAFASM
.|||......||...|     ..|. .|.|||.. .. |..||||    ||   .| ...  . ..|.....      | .||.||| .|..||..|. .
egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaa

IIGYQLVIQ--SLGSVKLEAVVSYIRSQRAMAITSALELAFVD
 . .|.. .    | | .  .| ..|.||..|...   . |. 
dlmlqqledklkeggvdileavkklReqRpgavqtleqyrfly

Y_phosphatase Protein-tyrosine phosphatase 811-1043 1.3e-46 154.2 Pfam-A 4-233 (235) alignment
Range on Protein: 811-1043
Range on HMM: 4-233/235.0
KQRLPIPLVMD-TRVVLKDYGTLFNddYIHANRV-TCSHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPES
|.| .  |..| ||| ||....  .  ||.|| | . ..  ..|..|.|       ..||||..|.   |||.. .||... .||   . . ||.|.||.
knRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgP.......lkstiedFWrmvwqekvkvivmltsleek...grekcaqYwpee

VGESMKFKNLTVECK--SKIAEKDFETRELEVKFDGHEP--HTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST----TPVMVHCIDGISRSAAFASMI
 .||.......||.|  .| .||.. .|.||.| ...|   ..|..  . .|.  .|. ..  ...||.|...|.    .||.|||..|..|.. |... 
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IGYQLVIQSLGsVKLEAVVSYIRSQRAMAITSALELAFVDAGI
|  . . .    |..  .|. .|.||.....|. ...|. . |
illeqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai

Y_phosphatase Protein-tyrosine phosphatase 811-1043 1.3e-46 154.2 In-house 4-233 (235) alignment
Range on Protein: 811-1043
Range on HMM: 4-233/235.0
KQRLPIPLVMD-TRVVLKDYGTLFNddYIHANRV-TCSHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPES
|.| .  |..| ||| ||....  .  ||.|| | . ..  ..|..|.|       ..||||..|.   |||.. .||... .||   . . ||.|.||.
knRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgP.......lkstiedFWrmvwqekvkvivmltsleek...grekcaqYwpee

VGESMKFKNLTVECK--SKIAEKDFETRELEVKFDGHEP--HTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST----TPVMVHCIDGISRSAAFASMI
 .||.......||.|  .| .||.. .|.||.| ...|   ..|..  . .|.  .|. ..  ...||.|...|.    .||.|||..|..|.. |... 
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IGYQLVIQSLGsVKLEAVVSYIRSQRAMAITSALELAFVDAGI
|  . . .    |..  .|. .|.||.....|. ...|. . |
illeqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai

0050432 (Phosphotyrosine protein) phosphatases II 812-1040 1.3e-44 148.1 In-house 73-292 (308) alignment
Range on Protein: 812-1040
Range on HMM: 73-292/308.0
QRLPIPLVMDTRVVLkdyGtlFNDDYIHANRVTCS---HGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPES
.   |.    .||.|   .   ..|||.|. |..    .  . |. |.|        ..|.|..|.   .....  ||.....|    . . ||.|.|..
rykdilpydhsRVkl...d..egsdYInAsyvdgyssklprkfIatqgPl.......pntvedFwrmvweqnvrvIvmLtklve...ngrekcaqYwple

VG-ESMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS--TTPVMVHCIDGISRSAAFASMIIGYQ
.| .|......||...|   ..|. .|.||... .. | .||||    .|   .| |..  . ........|    |..||| .|..|...|. . . ..
lgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllle

LVIQSlGSVKLEAVVSYIRSQRAMAITSALELAFVD
.. .  | | .. .| ..|.||......   . |. 
qleke.ggvdvfeavkklReqRpgmvqtpeqylfly

0039614 (Phosphotyrosine protein) phosphatases II 813-1041 4.2e-44 146.6 In-house 62-283 (297) alignment
Range on Protein: 813-1041
Range on HMM: 62-283/297.0
RLPIPLVMDTRVVLKDYGTL-FNDDYIHANRVTCSH--GLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKCPgKtnsCARYYPESV
   |.   ..||.||...   ...|||.|. |.. .  . . |..|.|..        |.|..|.  .....| .||.....|.   |   ||.|.||..
ykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe.......tvedFwrmvweqgvtvivmLtklvelgr.k...caqywpeeg

GesmKFKNLTVECKSKIAEKDFETRELEVKFdGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN------STTPVMVHCIDGISRSAAFASMIIGY
|   .....||.... . .... .|.|||.  . |..||||   .||   .| |.. |. ........      . .|| ||| .|..|...|. . . .
g...tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylml

QLViQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDA
... .. | | .. .|...|.|| .|...   . |.  
eql.ekeggvdvleavkelreqRpgavqtpsqyrflyd

0043336 (Phosphotyrosine protein) phosphatases II 811-1039 9e-44 145.4 In-house 49-269 (278) alignment
Range on Protein: 811-1039
Range on HMM: 49-269/278.0
KQRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCSH-GLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPesv
 .   |..   .||.|...|  ...|||.|. |.. . . . |..|.|..        |.| .|.  .....| .||.....|    . . ||.|.|   
nrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.......tvedFwrmvwelgvttivmLtelve...lgrvkcaqYwp...

GESMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN----STTPVMVHCIDGISRSAAFASMIIGYQ
|.|......||.... . ..|. .| |||.    .|..||||   .||   .| ... |. ........    | .||.||| .|..|...|. . . ..
ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllle

LViQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
.. .. | | || .|...|.||..|...   . |.
ql.ekeggvdleeavkelreqRpgavqtpsqyrfl

0045450 (Phosphotyrosine protein) phosphatases II 808-1039 1.6e-43 145.0 In-house 56-296 (307) alignment
Range on Protein: 808-1039
Range on HMM: 56-296/307.0
EQMKQRLPIPLVMDTRVVLKDYGTL-FNDDYIHANRVTCS---------HGLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpgK
  . .   |..  .|||.|....    ..|||.|. |..          .... |. |.|..        |.|..|.  .....| .||.....|.   .
kdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe.......tvedFwrmlweqgvtvivmltelvel...g

TNSCARYYPESvGESMKFKNLTVECKSKIAEKDFETRELEVKF--DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN------STTPVMVHCIDG
 . ||.|.|.. ||.. ..|.||...|.  ....  | |||.     .|..||||    ||   .| |..  . ..|.....      . .||.||| .|
rekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaG

ISRSAAFASMIIGYQLVIQSLGS--VKLEAVVSYIRSQRAMAITSALELAFV
..|...|. . . .... .      | |. .|...|.||  |...   . |.
vgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

0051299 (Phosphotyrosine protein) phosphatases II 815-1039 1.7e-43 144.5 In-house 57-278 (288) alignment
Range on Protein: 815-1039
Range on HMM: 57-278/288.0
PIPLVMDTRVVLKDYGTLFNDDYIHANRVTC-SHGLQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPEsvGESM
 |.   ..||.|....   ..|||.|. ...  .. . |. |.| .       .|.|..|.   .....  ||.....|    . . ||.|.|.  |.|.
dilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp.......ntvedFWrmvweqnvrvIvmltklve...lgrekcaqYwpl..ggsl

KFKNLTVECKSKIAEKDFETRELEVKF-----DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAFASMIIGYQ
.....||...|   ..|. .|.|||.       ..|..||||    .|   .| ... |. .........      ||.||| .|..|...|. . . ..
tygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllle

LVIQSlGSVKLEAVVSYIRSQRAMAITSALELAFV
.. .  | | .. .| ..|.|| .....   . ||
qleke.ggvdvleavkrlreqRpgmvqtpeqyrfv

0047943 (Phosphotyrosine protein) phosphatases II 812-1039 3e-43 143.6 In-house 43-264 (273) alignment
Range on Protein: 812-1039
Range on HMM: 43-264/273.0
QRLPIPLVMDTRVVLkdygTLFNDDYIHANRVTC-SHGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESVG
.   |. . ..||.|    .  ..|||.|. |..  .. . |. |.|        ..|.|..|.  ...... .||.....|    . . ||.|.|...|
rykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPl.......pntvedfwrmvweqnvrviVmLtelve...lgrekcaqYwplegg

E-SMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN------STTPVMVHCIDGISRSAAFASMIIG
| |......||...|   ..|. .|.||... . .|..||||    ||   .| |..  . ..|.....      | .||.||| .|..|...|. . . 
elsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdll

YQLVIQSlGSVKLEAVVSYIRSQRAMAITSALELAFV
.....   | | .. .| ..|||| .....   . |.
ldqleke.ggvdvleavkllrsqRpgmvqtpeqyrfl

0040439 (Phosphotyrosine protein) phosphatases II 810-1038 1.8e-42 141.1 In-house 14-237 (249) alignment
Range on Protein: 810-1038
Range on HMM: 14-237/249.0
MKQRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCSH-GLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPEs
. .   |.    .||.|.... || .|||.|. ..... . ..|. |.| .        |.|..|.  .....| .||.....|.   . . ||.|.|. 
knrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe.......tvedfwrmlwelgitvivmLtslvel...grekcaqywpl.

vGESMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN------STTPVMVHCIDGISRSAAFASMII
 |.|......||...| . ..|. .|.||...    |..||.| . ..|   .| |..  . ..|.....      . .||.||| .|..|...|. . .
.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

GYQLVIQSLGsVKLEAVVSYIRSQRAMAITSALELAF
 ....   || | || .|...|||| .|...   . |
mleqlekelg.vdleeavkllrsqRpgavqnpeqyrf

0046845 (Phosphotyrosine protein) phosphatases II 813-1039 6.9e-42 139.2 In-house 34-266 (284) alignment
Range on Protein: 813-1039
Range on HMM: 34-266/284.0
RLPIPLVMDTRVVLKDYGTL-FNDDYIHANRVTC------SHGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYY
   |.   ..||.|| ..    ..|||.|. |..       .  . |. |.|        ..|.|..|.   ..... .||.....|    . . ||.|.
ykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl.......pntvedFwrmvweqnvrvIVmltelve...ngrekcaqYw

PESvGESMKFKNLTVECKSKIAEKDFETRELEVKFD--GHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS------TTPVMVHCIDGISRSAAFA
|.. ||.......||...|.  ..|. .|.||...   . |..||||    .|   .| |..  . .........        |..||| .|..|...|.
ple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

SMIIGYQLVIQSLG--SVKLEAVVSYIRSQRAMAITSALELAFV
 . . ......      | .. .|...|.|| .....   . ||
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv

0042113 (Phosphotyrosine protein) phosphatases II 812-1038 9.7e-42 138.4 In-house 14-234 (245) alignment
Range on Protein: 812-1038
Range on HMM: 14-234/245.0
QRLPIPLVMDTRVVLKDYGTLFNDDYIHANRVTCSH-GLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPEsvG
.  .|..  .|||.|...|. . .|||.|. |....   ..|..|.|..        |.| .|.  .....| .||.....|    . . ||.|.|.  |
rysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe.......tvedfwrmlwelgittivmLteeee...lgrvkcaqywpl..g

ESMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN-----STTPVMVHCIDGISRSAAFASMIIGYQ
||......||...|   ..|. .|.|||.    .|...|.| . ..|   .| ... |. .... ...     | .||.||| .|..|...|. . . ..
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

LViQSLGSVKLEAVVSYIRSQRAMAITSALELAF
.. .... | || .| ..|||| .|...   . |
ql.ekelgvsleeavkelrsqRpgavqtpsqyrf

0045098 (Phosphotyrosine protein) phosphatases II 816-1036 8.3e-35 115.9 In-house 42-261 (278) alignment
Range on Protein: 816-1036
Range on HMM: 42-261/278.0
IPLVMDTRVVlkdygtlfndDYIHANRVTCShGLQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPEsvGESMKF
|. .  .||.          |||.|. ...  . . |. |.| .       ||....| . .....| .||.... |.   . . ||.|.||  |.|. .
ilpydhsrVk..........dYINAsyidgy.pkkfIatqgPlp.......stvadfwrmlwelgitvivmltelvel...grekcaqywpe..ggslty

KNLTVECKSKIAEKDFETRELEVKF-----DGHEPHTVTHSRLVGWNPLNVQPDT--LLFTSLIQKIKN-----------------STTPVMVHCIDGIS
...||...|    .|. .| |.|        . |...|||  ...|   .| ...    | .|.. |..                 | .|| |||  |..
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSAAFASMIIGYQLViqSlGSVKLEAVVSYIRSQRAM-AITSALEL
|..... . . ..|.    | | |. .|...|||| . |...   .
RtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqy

0037934 (Phosphotyrosine protein) phosphatases II 817-1033 2.1e-30 101.5 In-house 20-228 (243) alignment
Range on Protein: 817-1033
Range on HMM: 20-228/243.0
PLVMDTRVVLKDygtlfnDDYIHANRVTCSHglQLILSQAPQEAngeSCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPesvgESMKFK
..  ..||.|..      .|||.|| ...    .||..|.| .    ..|.. .|.|   .....| .||.....|.   . . ||.|.|    ... ..
lpydhsrvkleg......sdyinanliyvtp..rliatqgPlpe...tveddlasfwrmlwelgitvivmltelvEl...grekcaqywp....gevtyg

NLTVECKSKIAEKDFETRELEVKF--DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIK------------NSTTPVMVHCIDGISRSAAFASMIIG
..||...|    .|.  |.|...    ......|.|   ..|   .| ...  . .......            .|  || |||  |..|..... . . 
dftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylm

YQLViqslgSVKLEAVVSYIRSQRAM-AITSA
..|.     .| || .| ..|.|| . |... 
llll.....gvdleeavkllreqRpgkavqtp

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 862-1064 7.9e-30 98.8 In-house 33-237 (255) alignment
Range on Protein: 862-1064
Range on HMM: 33-237/255.0
GESCES-TIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVKFD-GHEPHTVTHSRLVGWNPL
  . .| |.. .. | .| |....||.||| |    . . | .|.|    | .|.....| .   .|.  . |.|.  ..    . |||.|    ||   
rknlysltvdkfyqtivqtktevvvmlcdfae...egvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiek

NVQPDTLLFTSLIQKIKNStTPVMVHCIDGISRSAAFASMIIGYQLVIQSLG-----SVKLEAVVSYIRSQRAMAITSALELAFVdagIVKLLGLFVDAQ
|   ..     ... ...|  .|.|||  || |||||. . . || .|.||       .    ..  .||.|. ||   |.|||    |. .| |.  ..
naPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs...ilmvldlvfpkg

QNKGELT--REQ
. . ...  |. 
eleakyqeirks

subfamily_hpo-7_pd Subfamily hpo-7 866-1061 1.5e-27 91.2 In-house 44-237 (263) alignment
Range on Protein: 866-1061
Range on HMM: 44-237/263.0
ESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVKFD-GHEPHTVTHSRLVGWNPLNVQPD
  ||.... | .| |....||.||| |      . | .|.|    | .|..|..| .   . .    |.||   ..   . |||.|   .||   |   .
vqtidkfyqtivqtktevvvmLcDfne...egvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpel

TLLFTSLIQKIKNStTPVMVHCIDGISRSAAFASMIIGYQLVIQSLG-----SVKLEAVVSYIRSQRAMAITSALELAFvdaGIVKLLGLFVDAQqNKGE
.     ...  .||  ...|||  || |||||. . . || .|.||       .    ..  .||.|. ||   . |||    |. .| .....   |||
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf...silmvLdfvlnnf.akge

LT
| 
le

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 804-1035 1.4e-26 88.4 In-house 44-271 (305) alignment
Range on Protein: 804-1035
Range on HMM: 44-271/305.0
ALKSEQMKQRLPIpLVMDTRVVLKDYGTLFNDDYIHANRVTCSHG-LQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCA
  . .. ... .. |  | |. |.   .| . ||| |. |   ..  . |..|.|        ..|.. .| .  .|| ...||...  |   |. . | 
eankaknrlkeit.lldddriiltekeslddsdyinasyvdgykrkkkyivaqgP.......lkntvadfWrliveekvstivmltklve...ggkdkCr

RYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVKF--DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS-----TTPVMVHCIDGISRSAA
.|.|||..|...| ...|| ||. . .|. .|.|.. .  . .| .||.. .|  |    |   .  . |||......      .|..||| .|..|. .
qYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGv

FASMIIGYQLVIQSlGSVKLEAVVSYIRSQRAMAITSALE
| .. |  . . .  ..| .  |.  .||.|  ....  .
fiavdialerlkkE.evvdvfevlkqlRskrmkmvqtldq

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 821-1031 6.7e-26 85.6 In-house 70-267 (290) alignment
Range on Protein: 821-1031
Range on HMM: 70-267/290.0
DTRVVLKDYGtlfNDDYIHANRVTCSHGlQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpGKTnSCARYYPESVGESMKFKNLTV
 |||.||| .   . ||.||| |   .   .||.| . ..       |.  .|    ||| . .||.|.  |.  ||.  |..||||  || . | ..||
ktrvilkdGy...dGdyvhanyvkGlka.mfiltqGalkd.......tvidiwrmvlqekvaaivmlcelied..Gka.kceqyypekeGevltfGeitv

ECKSK-IAEKDFETRELEVK-FDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSlGSVKLEAV
 |  .   ...   . | |.  |    | . | ... |    |   || .  ... ... . ||.|||  || |. .|... .| |....   ...|  .
lcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldG.keldlldl

VSYIRSQRAMAIT
|  .|  |. .. 
vralrnsrlnsvq

subfamily_PTPN3_pd Subfamily PTPN3 821-1046 1.2e-25 85.0 In-house 55-274 (280) alignment
Range on Protein: 821-1046
Range on HMM: 55-274/280.0
DTRVVLKDYGTlfndDYIHANRVTCSHGLQLILSQApqEANGESCESTIESYWWTAKQEKSTQLVMMCDFDEKcpGKTNsCARYYPEsVGESMKFKNLTV
.||| ||.  |    ||| || |      . .  .    |     ..| . .|   ...||. .||. .  |.  |..  | .|.||  ...... ...|
atrvklkeset....dyinanyvnmeipstglvnry..iatqGPlaktatdfWqmvweqksslivmlttlver..Grvk.ChqyWPe.tedeleygefsv

ECKSKIAEKDFETRELEVKFDG-HEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAFASMIIGYQlVIQSLGSVKL
.|... ..| . .||| .|    .| ..... . . |   .|  |.  | ........     ..||.|||  || |.  .  . .  . .|..  .|  
kcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala.lieaaepvyp

EAVVSYIRSQRAMAITSALELAFVDAGIVKL
 ..|. .| |||| . .|    ||   |.|.
ldivrtmrdqramlvqtasqykfvCeailkv

subfamily_PTPN23_pd Subfamily PTPN23 822-1039 7.9e-23 75.7 In-house 58-272 (288) alignment
Range on Protein: 822-1039
Range on HMM: 58-272/288.0
TRVVLKdygtLFNDDYIHANRVT--CSHGLQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGESMKFKNLT
.||.|.      .|||| |  |    .   ..| .|||..       ||.  .|    ..||  .||. . .|.   . ....||.||. ||..||..|.
nRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlq.......stlnDFWlmvyeqkssviVmllskeel...gkpkvdrYwPedkgetvkfgdls

VECKSKIAEKDFETRELEVKFDGHE-PHTVTHSRLVGWNPLNV--QPDTLLftSLIQKIKN--------STTPVMVHCIDGISRSAAFASMIIGYQLVIQ
| .||.   . .  |.|.... ...  ..|.| .|  |  | |   |.|||   .......        | ||..|||  |. |. .|| ..   . . .
vtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetll..qfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelek

SLGSVKLEAVVSYIRSQRAMAITSALELAFV
  | . .  ||| .| ||   .    .| |.
gnglldiiqvvsrlreqRrfmvqekeqlkfs

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 824-1041 3.8e-22 73.3 In-house 71-283 (305) alignment
Range on Protein: 824-1041
Range on HMM: 71-283/305.0
VVLKDYGTlfNDDYIHANRVTCSH--GLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpGKTnSCARYYPESVGESMKFKNL-TV
.|. |  .    |||||| | |      ..| .| |        . ||. .||   |.|  |.||.|   |   ||   ||.|.| . || ...|.   |
avkldkps..psdyihanyvgcpmipekrficaqgp.......ldqtidefwwmviqnkveqivmlcktvel..gkl.kcaqywpaaqgeklelksgivv

EC--KSKIAEKDFET--RELEVKFDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSLGSVKLE
|    ||  |.| |     |.. . | .  .| | .   |    | |  |    |.  |. |  |..|||  || |. .  ..    . . .      . 
envsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmp

AVVSYIRSQRAMAITSALELAFVDA
 .|  .| |||..| . ..  |.  
elvkalrdqrafsiqndvqylfihr

subfamily_Ptp69D_pd Subfamily Ptp69D 807-1041 5.8e-22 73.2 In-house 47-280 (307) alignment
Range on Protein: 807-1041
Range on HMM: 47-280/307.0
SEQMKQRLPIPL-VMDTRVVLKDYGTLFNDDYIHANRVTCS-HGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARY
  ..| | .      .|||.||      . ||| |. .    .  . | .|.|        |.||. .|    . ..| .||. . .||   . . ||.|
enalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdP.......veatigDfWRmiaeqevtlivmlsnltek...nrkkcakY

YPESvgESMKFKNLTVECKSKIAEKDFETRELEVKFDG------HEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKI----KNSTTPVMVHCIDGISRSA
.|.   . ... .. |.. |.   .|.  |||.|   .      .. . |.  .  ||.  .|   .     ||...    |.. .|..|||  | .||.
Wpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsg

AFASMIIGYQLvIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDA
 | .. .  |  ..   .|.. ..|  .|||| . ..|     |.  
ifvaldsllqq.lkaedkvdifetvkdLrsqRnllvqsleqYvflyr

subfamily_PTPN6_pd Subfamily PTPN6 810-1039 3.4e-21 70.5 In-house 56-289 (306) alignment
Range on Protein: 810-1039
Range on HMM: 56-289/306.0
MKQRLPIPLV-MDTRVVLKdYGTLFNDDYIHANRVTCSHGLQLilsqAPQEANGESCESTIESYWWTAKQEKSTQLVMMCDFDEKcpGkTNSCARYYPES
 |.|    |   .|||.||    . ..||| || .. .   .     .   |   . |.|.. .|  . ||.|. .||.    |.  |  . ||||.|..
eknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsd....ksyiatqgclettvsdFWrmvwqensrvivmttkevEr..g.kekCarYWPde

VGESMkFKNLTVECKSKIAEKDFETRELEVK--FDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST--------TPVMVHCIDGISRSAAFAS
  ... . ...|.. |. . .|.. ||| |.   ...| ..| . .   |   .|. |.  . ........ .         |..||| .|| |  .|  
eekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiv

M--IIGYQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
.  ..           . .. .| ..|.||   .  .    ||
iDillkliekkgldadidiqklvksvreqrsglvqteqqykfv

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 803-1039 6.8e-21 69.4 In-house 41-275 (290) alignment
Range on Protein: 803-1039
Range on HMM: 41-275/290.0
EALKSEQMKQRLPIPLVM-DTRVVLKDYGTL--FNDDYIHANRVT-CSHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpGKt
.  .|.. ..|    .|  | |..|.. .     ...||.|  .   ..  | |. |.|        ..|.  .|   .|||.| .||...  |.  || 
gltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgp.......vsntlvdFWkliwqekvtiivmltniiee..gk.

NSCARYYPESvgESMKFKNLTVECKSKIAEKDFETRELEVKFDGH--EPHTVTHSRLVGWNPLN----VQPDTLLFTSLIQ-KIKNSTTPVMVHCIDGIS
. |  |.|.|  .. .. . ...  .  . ... .|.|||| .    ....||. ..  |..       |  .|...  .. . |.  |...||| |...
vkCqqYWpds..dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvg

RSAAFASMIIGYQLViQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
||| | .. .. . . .. | . . .|.   |.|.   .... .. ..
rsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgi

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 821-1044 1.1e-20 68.9 In-house 55-273 (281) alignment
Range on Protein: 821-1044
Range on HMM: 55-273/281.0
DTRVVLKDYGTLFNDDYIHANRVTCSH-GLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVgESMKFKNLT
 |||....  .  | ||| || |   .   . | .|.|         ......|.   ..| ...||.    |.       | ||.|.   ...|. ..|
atrvkvtpneenkntDYinanfvpgykgekeyiatqgP.......vPaslvafWqmvweqkvsaivmvtreiea...gklkChrYWPddn.selkygdvt

VECKSKIAEKDFETRELEVKFDGHEPHTVTHSRLVGWNPLNVQPDT---LLFTSLIQKIKNSTT--PVMVHCIDGISRSAAFASMIIGYQLVIQSLGSVK
|. ... ... . .|..... .. |. .|.. . . |    |  .|   | | . ..|.... |  |...||  |. |. .. ..    . | ..| ...
vkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeld

LEAVVSYIRSQRAMAITSALELAFVDAGIV
..|||  .| .| . . . .  .||   ..
vkavvaelrkernlmvqtvvqyefvykavl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 808-1043 1.3e-20 68.7 In-house 47-275 (288) alignment
Range on Protein: 808-1043
Range on HMM: 47-275/288.0
EQMKQRLPIPLVMD-TRVVLKDYGTLFNDDYIHANRVTCSHGL-QLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYY
 . | | .  | .| .|| ||.  .  . ||| |. .  ...  . | .|.|         .|.. .|    ..|.. .||. .. |.     . | .|.
nakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPla.......dtvndfWelvyenktstivmltelveg...gktkCeeYW

PESvGESMKFKNLTVECKSKIAEKDFETRELEVKfDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAFASMII
|.. ..  .. ..||. ...  ..|| .|.|...   ..  ..|. .  .|   .|  ..  .  |....|..    | |..||| .|. |.  | ..  
Pda.dkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialda

GYQLvIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGI
  .  ...   . . ..|. .| |||. .       |.   .
lida.veeedyiDvagtvaklRkqRallvqtlkqYefiyevl

subfamily_PTPN13_pd Subfamily PTPN13 820-1048 1.3e-20 68.9 In-house 50-270 (273) alignment
Range on Protein: 820-1048
Range on HMM: 50-270/273.0
MDTRVVLKDYGTLFNDDYIHANRvtCSHGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDfdEKCPGKTnSCARYYPESVGESMKFKN-L
 .||| |.| |.  | ..|...     .  . |..| |          |.. .|    . |.. ..|.    ||  ||   | ||.||| ....| .| |
detrvklgdeggyinaslikvpv..gkdeyeyiacqGPl.......Petvkdfwqmvweqkaeviamvtl..ekekgkv.kchrywPesknkklkvsnrl

TVECKSKIAEKDFETRELEVK-FDGHEPHTVTHSRLVGWNPLNV--QPDT-LLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSLgSVK
.||       ..|  |.|.||  .  | . |.| ..| |   .|  ...  | | . .........|..|||  || || .. .. .  .|. .   ...
evellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdk.efd

LEAVVSYIRSQRAMAITSALELAFVDAGIVKLLG
.. .|  .| ||   . .     ||   |...|.
vkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 821-1043 1.8e-20 67.5 In-house 57-272 (515) alignment
Range on Protein: 821-1043
Range on HMM: 57-272/515.0
DTRVVLKDYGTLFNDDYIHANRVTCSHG-LQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESVGESMKFKNLT
 .|| |.      . ||. |  .   .     | ||.|..|       ... .|    ||. | ..|. .  |   |    |..|.|.  |.|.|| .. 
svrvklevindnPhsdyfnasyipsfdndkayiasqgPnka.......svddfWrlvlqenvttiamvtklke...gdkikcgkyWPdkpgdsvkfGsik

VECKSKIAEKDFETRELEVkFDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST----TPVMVHCIDGISRSAAFASMIiGYQLVIQSLGSVKL
||  |  |  .   |.|.|   | . .|||  .. .|    |...|  .  ||...| ..     |...||  |. |   . |.       ..   .| .
velvsleactggikrkltv.lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid.svvahakttrmvdv

EAVVSYIRSQRAMAITSALELAFVDAGI
  .|  || .|   .    . ||.   .
fnfvtnirqkrpylvqtqeqyafiygav

subfamily_PTPRD_pd Subfamily PTPRD 790-1052 2.1e-20 67.9 In-house 29-286 (564) alignment
Range on Protein: 790-1052
Range on HMM: 29-286/564.0
FDAMNEKYEVPGREALKSE-QMKQRLPIPLV-MDTRVVLKDYGTLFNDDYIHANRVTC-SHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVM
.  ..|. ... ..| |.. ..| |.   .    .||||. .    . ||| |. .    .  . | .|.|        ..||| .|    ...|.  ||
ykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgP.......laetiedFWRmvweqnsstiVm

MCDFDEKcpgKTNSCARYYPESvGeSMKFKNLTVECKSKIAEKDFETRELEVK-FDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTP
.    ||   ... |..|.||. | . .. .|||. ...   .|.| |....|  . .| ..|..   . |   .|   .  . .||.|....    . |
ltkleEk...gkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagP

VMVHCIDGISRSAAFASMIIGYQLvIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLGLFVD
..|||  |. |. .|  . .  .  |.. . | .  .|. .|.|| . . .    .|.   |.. |  ...
ivVhCSaGVGRTGtfividamler.ikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 814-1044 2.2e-20 67.8 In-house 30-261 (270) alignment
Range on Protein: 814-1044
Range on HMM: 30-261/270.0
LPIPlvmDTRVVLKDYGTLFNDDYIHANRVTCSHG--LQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGE
|| |    |||.|..  .  .  || || |   .|   . | ...|...       |..|.| .  .||.| .||. .. ||    .. |.||.|....|
LPsP...atRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpt.......tlksfwrmiweekvtaivmttgleEk...grkkCerYWpaepke

--SMKFKNLTVECKSKIAEKDFETRELEVKFDGHEpHTVTHSRLVGWNPLNV--QPD-TLLFT---SLIQKI---K---NSTTPVMVHCIDGISRSAAFA
  .... ...|   |.  |. . ...|... .|.| . ..|   . |.   |  ..| .|  .   ......   .   . ..|..||| .|. |.  . 
kvkledgkikvlalseekeegyiltrlrleekgee.rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

SMIIGYQLvIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIV
 . |. .| ... ..| . |... .| .|   .    . .|. ...|
alDiavrl.LeetkkvdvlaiieelRkdRmalvqhpeqyeflykavv

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 814-1030 2.6e-20 67.2 In-house 44-251 (281) alignment
Range on Protein: 814-1030
Range on HMM: 44-251/281.0
LPIPLVMDTRVVLKD-YGTLFNDDYIHANRVTCSHG-LQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGE
| || .  .|| ||         |||||| .         ||.| |..        |   .|    ||..| .||.|.| |    . . || |.|     
lnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkk.......etradfwrmiwqenttaivmlcqflet...nrekcaeyfprnahc

SMKFKNLTVECKSKIAEKDFETRELEVKFDGhEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSLG
 ..| .|.|. .    .| . |  |.. ..| | . .||     |   .|   . ..  ...||.  .|| ..||  |. || .. .. |  | .   . 
clqfdklsvsyedstvnkslvttrlnlsyeg.etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshft

SVKLEAVVSYIRSQRAMAI
   .. .||..|     | 
lpdikqivshlrvtgraas

subfamily_egg_pd Subfamily egg 818-1044 4.2e-20 66.6 In-house 51-267 (307) alignment
Range on Protein: 818-1044
Range on HMM: 51-267/307.0
LVMDTRVVLKDYGTLFNDDYIHANRVTCSHGL-QLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgktNSCARYYPESVGESMKF-
    .|| |.     . ||.||||||     | ..||.|||          | . .|    ||.   .||.    |      . |  |.| .  .|... 
ckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplk.......ntvddfwrmvfqeevqyivmltsrkes.....erceyywpkaesdslvtv

-KNLTVECKSKIAEKD--FETRELEVKFDGHEPHTVTHSRlvgWNpLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQS-LG
  .| .|.     . |  |   .| .    .|   . | .   .. .|   |      ...|..| ..||.|..|.|.|..|.. .. |    ...  . 
pGslrienlkvdskadplfrvtklklvGgddeerflehwq...gd.vnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpit

SVKLEAVVSYIRSQRAMAITSALELAFVDAGIV
   .   | ..| .| ... |.|   ||   ..
kslvlravvflrlrrrlsvesvllylfvyrlvl

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 802-1038 4.7e-20 66.8 In-house 35-268 (307) alignment
Range on Protein: 802-1038
Range on HMM: 35-268/307.0
REALKSEQMKQRL-PIPLVMDTRVVLKDYGTlfNDDYIHANRVTCS-HGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEKCpgKTn
 ||..... |.|   .. .  .|.|.|  |     |||||| .  . .  ..| .| |.       |.|. |.|  | |||   ..|.|.  | .  |  
veafsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpkkficaqgpl.......entqysfwamaiqekvesvimlckviela..ki.

SCARYYPESVGESMKFKN----LTVEC--KSKIA--EKDFETRELEVKFdGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGIS
 | .|.|   |. . | .    ..|.     |.|  |.  .  .|.|.. ...  |..| .   |    | .  |    |.. ..  | ||.|||  |. 
kceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdw.aqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvG

RSAAFASMIIGYQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAF
|| .  .. .  . .|.     ... .|  .||||  || . ..  .
rsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyly

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 812-1044 4.9e-20 66.6 In-house 48-274 (315) alignment
Range on Protein: 812-1044
Range on HMM: 48-274/315.0
QRLPIPLV-MDTRVVLKDYGTLFNDDYIHANRVTCSHG-LQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESV
 |    |    .||.|.      ..||| |  .   .     | ||.|..|       ... .|    ||| | .||. . .|   |   .|..|.|.  
nryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka.......svddfwrmvlqekvttivmvtkkqe...gdkikcrqywPdrk

GESMKFKNLTVECKSKIAEKDFETRELeVKFDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----TTPVMVHCIDGISRSAAFASMIIGYQl
..|..| .. ||  |  |  |  .|.| |  ...| .|||  .. .|    |. .|  .  ||...| .    . ...|||  |. |.  . |.    . 
adsvefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevva.

VIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIV
 |.   || .  .|  .|..|   . .  | ||.   . 
qikrtrsvdvfnfvknlrakrpylvqteeeyafiydavl

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 809-1045 5.1e-20 66.8 In-house 49-286 (325) alignment
Range on Protein: 809-1045
Range on HMM: 49-286/325.0
QMKQRLPIPLVMD-TRVVLKDYGTLFNDDYIHANRVTCSHGLQLIL-SQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEkcpgKTNSCARYYP
. | |..  . .| .||||.  .   . ||| |. .    . .  | .|||. |       ||.  |  . . ... .|..  .|.    . ..|| |.|
kaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPlta.......tindlWrlvldWrcsvvvvlneldl....gkdrcavywp

ESVGESMKFKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNV--QPDTLL-FTSLIQKI----KN---STTPVMVHCIDGISRSAA
. .|.| .|  | |. ..     |.  | |.||  .. |  .|   .| .|. . |  .| ||. .. |....    .    ..||..|||..|. |. .
kemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FASMIIGYQLVIQSlGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVK
|.|.    . ||.   .| .  .|  .| .|   . .. .  ..  ..|.
fislysalakviee.srvdifgfvkklrkdrpsmvetvdqyiliyealve

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 838-1044 2.6e-19 64.1 In-house 78-278 (301) alignment
Range on Protein: 838-1044
Range on HMM: 78-278/301.0
IHANRV-TCSHGLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGESMKFKN--LTVECKSKIAEKDFETR
|||| . |  |  ..| .|.| ..       | | .|   .| .  ..||.. . ||   ... |. |.| ...|... .   .... | .| .|.   |
ihanwiptsGhphrfiatqgPlkn.......tsedfwamlvqydvekivmlgqkvek...leekceeylpvkisekldigrfkikiknkelilnkkiskr

ELEVKFD--GHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLViQSLGSVKLEAVVSYIRSQRAMAITS
.|||.      ...|||| . . |   .|         |.. .|.|  |..||| .|| || || .  .  . | ..   ..|   .  .| .|  ..  
tlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylarev.eadptieltealkhlrehrwngvqt

ALELAFVDAGIV
   | ..  | |
nsqlywmtlGtv

subfamily_PTPRB_pd Subfamily PTPRB 819-1047 3.5e-19 64.0 In-house 63-285 (293) alignment
Range on Protein: 819-1047
Range on HMM: 63-285/293.0
VMDTRVVLKDYGTLFNDDYIHANRVTCSHGLQ-LILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpGKTNsCARYYPESVgESMKFKN
   .|| |..  .  ..||| || .   .  .  | .| |         .|.. .|    ..||. .||. .  ||  ||.  | .|.|.   |.. . .
ydhsrvkLaalkdesgsDYinanyipgynsprefiatqGP.......lpetvddfWrmvwekkssiivmltqlvek..gkvk.CeeYWPade.epvlyGd

LTVECKSKIAEKDFETRELEVKFdGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIK------NSTTPVMVHCIDGISRSAAFASMIIGYQlVIQSLG
..|. ...   .|. .|||...  ..| ..|.. . . |   .|  .|  . .......      .|..|..|||  |. |. .| ..    |  |..  
ikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllq.aieeed

SVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLL
 | . ..|. .|..|.. . .  .  |..  ...||
yvdifgivaelReeRnllvqtekqYifihqcvldll

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 808-1052 7e-19 63.2 In-house 56-295 (298) alignment
Range on Protein: 808-1052
Range on HMM: 56-295/298.0
EQMKQRLPIPLVMD-TRVVLKDYGTLFNDDYIHANRVTCSHGL-QLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYY
 . | | .  . .| .||||..  .  . ||| |  .   .|    |..|||        ..|.| .|    .|... .||. .  |.   ..  . .|.
nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP.......ltetvedFWrmvteedigtiVmltnleel...dktkyhkyw

PESvgESMKFKNLTVECKSKIAEKDFETRELEV-KFDGHEPHTVTHSRLVGWNPLNVQPDTLL---FTSLIQKIKNSTT--PVMVHCIDGISRSAAFASM
|..  .. .. ..||. .||    |...|.|.| | . .. ..| . . . |    |   .     . . ... .. .   ||.|.| .|. || .|  .
Pde..gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiai

iIGYQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLGLFVD
       ..   .| .  || ..| .|. |...  . .|.   . . |  | |
.dsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnd

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 834-1032 7.6e-19 62.7 In-house 61-251 (283) alignment
Range on Protein: 834-1032
Range on HMM: 61-251/283.0
NDDYIHANRvTCSHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESvGeSMKFKNLTVECKSKIAEKDFET
|  .|  ..    .. . | .|.|        . |.  .|    .|| | .||.  . |   ..   |..|.|.  | |... ..||  .   ... |  
navfipvsk.sykqdkkyiiaqsP.......ldrtvvdfWkmvfdekitaivmltklqe...dlrikCsqyWPkr.G.sedyGeftvtlrkettsnsfii

RELEVKFDG--HEPHTVTHSRLVGWNPLNVQP--DTL-LFTSLIQ-KIKNSTTPVMVHCIDGISRSAAFASMIIGYQLViQSLGSVKLEAVVSYIRSQRA
.|| .. ..  ..   ..| ....|   . |.  ..|  |  .|  . ..  .|..|||  || |.|.| ..    . . ..   | . |||  .| || 
kelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda.ltesvvdvfavvkimreqrm

MAITS
||. .
mavqt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 804-1048 1e-18 62.5 In-house 43-284 (319) alignment
Range on Protein: 804-1048
Range on HMM: 43-284/319.0
ALKS-EQMKQRLP-IPLVMDTRVVLKDYGTLFNDDYIHANRVTC-SHGLQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKCpgKtNS
| |   . | | . |  .  |||||...    . ||| |. .    .  . |  ||| |        ||| .|    .|.|  .||...  ||   |   
askeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPle.......ntiedfWrmvWeeessivvmltklvekl..k.vk

CARYYPESvgESMKFKNLTVECKSKIAEKDFETRELEVKFDGHEP--HTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST-----TPVMVHCIDGISRS
. .|.||   . ... .|.|. ...   .|.. |.|...    |    .|.|     |   .|  ....   |...|..|.      |..||| .|. | 
lkkywpee..nfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRt

AAFASMIIGYQLViQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLG
 .|  . .  . | .  | . .  .|| .| || . .       |.   ... . 
Gtfivldamlerv.keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave

subfamily_PTPN12_pd Subfamily PTPN12 821-1047 1.7e-18 61.5 In-house 54-277 (290) alignment
Range on Protein: 821-1047
Range on HMM: 54-277/290.0
DTRVVLKDYGTLFNDDYIHANRVTCSHG-LQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGESMKFKNLT
 .||.|.      ..||| || .  ..| |. | .|.|          |.. .|    . . . .||.|   |    . . |.||.||...|...| ...
ksrvelskieeeegsdYinanfikgvegkleyiaaqgP.......LpktlddfWrmiweknveivvmaCrevel...gkkkCerYWpeegeeelefgefe

VECKS-KIAEKDFETRELEVKFDgHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIK----NSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSLG--S
|.... |  ..||  | |.|... .| ..|.  .   |   .|   .    .||....    .. .|..|||  |. |  .  .. . ..|. .     .
vtleeekavdddflirtLkveaq.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipee

VKLEAVVSYIRSQRAMAITSALELAFVDAGIVKLL
...  .|  .| ||| .. .     .|   ...|.
ldvfdlvlelrkqraalvqtkeqyelvykavaelv

0044763 (Phosphotyrosine protein) phosphatases II 820-1031 3.2e-18 61.4 In-house 3-155 (178) alignment
Range on Protein: 820-1031
Range on HMM: 3-155/178.0
MDTRVVLKDYGTLFNDDYIHANRVTCShglqLILSQAPQeangescestiESYWWTAKQEKSTQLVMMCDFDEKCpgkTNSCARYYPESVGesmkfknlt
 .|||.|  .  |.  |||.|....      |.|...|.           ....   |... | .|.... .|      ..| .|.||. |         
drtrvllsnleglersdyinaseilpg....lylgslpp...........addlellkelgithivnlteelelg...flkcdpywpeeag.........

veckskiaekdfetrelevkfdghepHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIK-NSTTPVMVHCIDGISRSAAFASMIIGYQLviqslgSVKLEAV
                           .. |  ...... ..   .| |. .|...  ..  || |||  |..||.... . . ..|      .. ||..
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleea

VSYIRSQRAmAIT
....|..|  ...
ielvrerRp.ivp

0041856 (Phosphotyrosine protein) phosphatases II 831-1032 4.5e-18 60.9 In-house 17-156 (182) alignment
Range on Protein: 831-1032
Range on HMM: 17-156/182.0
TlfNDDYIHANRVTCSHGL-QLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCdfdekcpgktnsCARYYPesvgesmkfknltveckskiaek
   . |||.|| . .|.   . |. |.|          |..... . |... | .|...            . .|.|                       
r..dldyInanlylgslpatrfiatqgplls.......tvadflrmlkelgittivnlt............eelywp.......................

dfetrelevkfdGHEPHTVTHSRLVGWNPLNVQPdTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLviqslgSVKLEAVVSYIRSQRAMA
             ........ . ..|   .| . .  . ..|......  || |||  |..|..... . . ..|      .| || .|...||.| ..
............ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl......gvsleeavklvrsrRpgm

ITS
...
vit

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 810-1043 9.9e-18 59.1 In-house 49-274 (287) alignment
Range on Protein: 810-1043
Range on HMM: 49-274/287.0
MKQRLPIPLVM-DTRVVLKdygtLFNDDYIHANRVTC-SHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPE
 | ||   ||  . ||.||      ..||| |  .   ..  . |....|         .|.  .|   .... | .||.|.  |.   ... | .|.||
dknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesP.......mfntarnfWkliddrnvtaivmlcqeken...deevcyqyWpe

SvgESMKFKNLTVECKSKIAEKDFETRELEVKFDG--HEPHTVTHSRLVGWNPLN--VQPDTLL--FTSLIQ-KIKNSTTPVMVHCIDGISRSAAFASMI
.  .|. . . ..|  ..  ....  |.|||| ..   ....|.  ..  |.      .| | |  .   .. . |.. |...||| |.. ||| | .. 
e..ksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaa

IGYQLViQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGI
.. . . .  | . .  |.   | |.  ..  . .  |.   .
ttinkc.kteGviDvfqvlksqriqkpgsvqtveqykfindiv

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 818-1044 1.1e-17 59.2 In-house 61-281 (297) alignment
Range on Protein: 818-1044
Range on HMM: 61-281/297.0
LVMD-TRVVLKDYGTLFNDDYIHANRVTCSHGlQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpgkTNSCARYYPESVGESmkFK
| .|  || |.  ..  . ||. |  |   .  .|| .| |..|       |.. .|    .|. . .||. | .|.    ...||||....   .  | 
LPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmka.......tvadfWamvldeqvstivmlnddner....dkkcaryWsdkgvtt..fG

NLTVECKSKIAEKDFETRELEVKFDG-HEPHTVTHSRLVGWNPLNVQP--DTLLFTSLIQKIKN-----STTPVMVHCIDGISRSAAFASMIIGYqLVIQ
...|. .|    . |  |||||. .     . |   . | |   .|.   ..  .  ||. ...     . .|..|||. |. | . . ..       ..
dvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvv.aeak

SLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIV
   .| .  .|. .| .|   .    . .||   ..
rekevdifglvkklrqerpylvqtkeqykfvyvavl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 779-1039 2e-17 58.1 In-house 5-260 (274) alignment
Range on Protein: 779-1039
Range on HMM: 5-260/274.0
EELIKKFYGVKFDAMNEKYEVPGREalKSEQMKQRLPIPlvmDTRVVLKDYGTLF-NDDYIHANRVTCSHGLQL--ILSQAPqeangesCESTIESYWWT
..| |.|. .  .  .|...|.| .  . .. |. || .    .||.|.   .   . .|| || .   .. .   .  | |         .|.. .|  
kdlekeflelPlnfdqeeldvfgsq..tknryktilPne...nsrvllesessededssyinanyikGydeeskayvatqGP.......lpntvadfWrm

AKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGE--SMKFKNLTVECKSKIAEKDFETRELEVKFDGHePHTVTHSRLVGWNPLNVQPDTLLFTSLIQ
  ||... .||. .. |.   . . ||.|.|.. .   | ..... .. .... ..|.. |.| .|   . ...|.|     |   ..  |.  . .|..
iyqeevqvivmltklkea...neqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvl

KIK-------NSTTPVMVHCIDGISRSAAFASMIIGYQLViQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
...       . ..||.|||  || |  .| .. |. . . .  . | .  .|. .| .|   . ..    ..
eveesreeenaklapvvvhCsaGiGrtGcfiaisiavrql.reeivvdvlkivcnlrldrGGmvqtseqyeli

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 770-1043 2.9e-17 57.3 In-house 6-283 (305) alignment
Range on Protein: 770-1043
Range on HMM: 6-283/305.0
KETCIPFLSEELIKKFYGVK--FDAMNEKYEVPGREALKSEQ--MKQRLP-IPLVMDTRVVLkdyGTLFNDDYIHANRV-TCSHGLQLILSQAPQEange
|   . |. . | |   |..  | ||.   ..   .|.|  |   |.|   .  . . || |    . .  .||||| | | .   ..| .||| |    
kkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaple....

sceSTIESYWWTAKQEKSTQLVMMCDFDEKCpgkTNSCARYYPESVGESMKFKN----LTVECKSKIAEK-------DFETRELEVKFDGHEPHTVTHSR
    |   .|.   |.|  .. |.|.. ||    .. |. |..   .. ..|..    ..| ..|  . |       . .  .| ..  |.. . |||  
...ktcadfwymclqdkveaifmlcnllekg...akkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyh

LVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFasMIIGYqLVIQSLGSVK---LEAVVSYIRSQRAMAITSALELAFVDAGI
 . |    | .  |    |..| . |  |..|||  || |. .   ... | .. | |.  .    . ..  || ||  .| .  .  ||   |
widwpdrgvpaadlailellekarpskgpivvhcsagigrtgsv..vmley.ildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvi

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 820-1044 4.8e-17 56.7 In-house 51-274 (287) alignment
Range on Protein: 820-1044
Range on HMM: 51-274/287.0
MDTRVVLKDYGTLfNDDYIHANRVTC-SHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESvGESMKFKNL
 ||||.|   | |   ||| || |.   .  . | .|.|         .|. ..|    ...|. ...|    |.     . | .|.||     |.    
ddtrvllsaegel.GsdyinanyvasytddeafiaaqgP.......iaatvrdfwravletrsasvitmtrevee...arlkcykywPer.evPmrvGGy

TVEC-KSKIAEKDFETRELEV-KFDGHEPHTVTHSRLVGWnPLNVQPDT----LLFT-SL-----IQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLv
.|   . .| | .. .| | . . ...| . |    |. | | .| . |    . |. .      ...  . . |..||.  || ||  . ....  .  
svvlldydikePeygvralrlidletrearvvkqldllsw.PdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsr.

IQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIV
 ..|| |   ||| ..| .||  . ... | ..   .|
ledlGrvdvaavvirlreyraalvqavvqlrllyealv

0051429 (Phosphotyrosine protein) phosphatases II 835-1041 5.7e-17 57.7 In-house 4-219 (272) alignment
Range on Protein: 835-1041
Range on HMM: 4-219/272.0
DDYIHANRVTCShgLQ------LILSQAPQEAngescesTIESYWWTaKQEKSTQLVMMCDFDEKcpgKTNSCARYYP----------ESVGESMKFKNL
..||.|. |      .      |..|..| ..       |....|.  |... .  |.... .|.   . . | || |          ... ... . .|
sgyiNardvggy..grvvkpgrlyrsggplpl.......taadfwrl.kelgiktivdLrseeEr...grlkcdrywpgirylhlpilddsaptilygal

TVECKSKIAEKDFETRELEVKF--DGHEPHTVTHSRLVGWNPLNVQPDTllFTSLIQKIKNsTTPVMVHCIDGISRSAAFASMIIGYqLVIQSLGSVK--
.| . |..   |.  |||....  . .|...|.|    .|   .| ...  . .|.. . .   ||.|||  |..|.. .. ... . | .     |.  
rvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddY

------LEAVVSYIRSQRAMAITSALELAFVDA
      ||..|...|.||. |. .   ..|.  
lltnlyleeaveelraqrpgavqteeqylflye

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 819-1040 7.9e-17 56.1 In-house 47-263 (285) alignment
Range on Protein: 819-1040
Range on HMM: 47-263/285.0
VMDTRVVLKDYgtlfNDDYIHANRVTCSHGLQ--LILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESVGESMKFK
. .||||||..    . |||||. .      |   | .| |          |.  .|    ||| . ..|.| . |   |  . || |||| .|| .|| 
ieetrvvlknh....drdyihaswmrmpgkdqstyittqgp.......lpetlsdfwhmiyqekiayvlmlctlfe...ggvekcalyypeklgevvkfg

NLT---VECKSK-IAEKDFETRELEVKF-DGHEPHTVTHSRlVGWNPLNVQPDT----LLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGyQLVI
.      ||| . ||   ...  .        ||  . | . | | | .. |.     . .   ..|..   .|. |||  |. |.|.|  .     . |
kyeitlteckeeaiagtilnaltvintedasseplymnhvq.vpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya.tiri

QSLGSVKLEAVVSYIRSQRAMAITSALELAFVD
     ...  .|  .|. |  |. | ... |. 
menpniemldivremramrfqavqshmqflfly

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 821-1048 8.5e-17 56.2 In-house 60-281 (318) alignment
Range on Protein: 821-1048
Range on HMM: 60-281/318.0
DTRVVLKDYGTLFNDDYIHANRVTCSHGL-QLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKCPGKtnsCARYYPESvgESMKFKNLT
.||| |..  .  . ||| || .   .   . | .|||          ||| .|    . .|. .||. .  |..  |   ..||.|..  .|.....|.
htrvkLqmlegeegsDyinanyidGyrrkkayiaaqaP.......lpetieDfWrmvWeqnsavivmltqeeergkak...vhryWPsk..gsrsygklv

VECKSKIAEKDFETRELEVKFDGH-EPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST-----TPVMVHCIDGISRSAAFASMIIGYQLvIQSLGSV
|| |...  .|.  ||..|. ... |  .|   .   |   .|  ..  . .|......       .|..|||  |. |   |  . |  .  |.  . |
velkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdiller.ikaealv

KLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLG
 .  .|. .|.|| . .       |.   ... | 
Dvfqtvkqlreqrnlmvqtedqyefiydvlleala

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 821-1051 8.7e-17 56.1 In-house 23-246 (250) alignment
Range on Protein: 821-1051
Range on HMM: 23-246/250.0
DTRVVLKDYGTLFNDDYIHANRVTCSHGLQ-LILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpGKTnsCARYYPesVGESMKFKNLT
 .||||.   .  . ||| |  .   .. .  | .|.|        ..||| .|    .|||. .||. .. |.  .||  . .|.|  | .. |. ..|
ssrvvLekekgdkesdyinasflhgyderkafiatqgP.......lqatiedfWrmvleeksgtivmLtnLkes..ekt..yhqywP..vekaekyGdvt

VECKSKIAEKDFETRELEVKFDGHEPH-TVTHSRLVGWNPLNVQ---PDTLLFTSLIQKIKNS--TTPVMVHCIDGISRSAAFASMIiGYQLVIQSLGSV
|. .||    |...|.| .    .. . .| .   | |    |       | . . .|. ..   ..||.|.|  |..|| ||  .       ..    |
vsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid.avlerlkkekvv

KLEAVVSYIRSQRAMAITSALELAFVDAGIVKLLGLFV
 .  |.  .| .|  |..|     ||   | | |  . 
dvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_PTPN9_pd Subfamily PTPN9 818-1039 1.7e-16 55.1 In-house 53-282 (297) alignment
Range on Protein: 818-1039
Range on HMM: 53-282/297.0
LVMDTRVVLKDYGTLFNDDYIHANRVTCSHGLQ-LILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGESMKFK
 . .|||||.      . |||.|| |   .  . .|  | |        . |.. .|    ...   .||.  . |.   .   |..|.|.. ..|..| 
cydetrvvlakvdedeasdyinanfvdGykqkkafiatqGp.......lkktvsdfWrmvWeqevlvivmttrvver...grlkcgqyWpleeessaefg

NLTVECKSKIAEKDFETRELEVK-FDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKI-----------------KNSTTPVMVHCIDGISRSAAFAS
.|.|.  .   |.|...| ||.|  . .|  .||| ....|    |  ..  .  ...|.                 . |  |..|||  || |. .|..
dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfit

MIIGYQlVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
. |  .  ....| |..  .|...|.||| .|      .| 
ldicls.rleevgtvdvvetvkllrtqrafsiqtpeqyefc

0049772 (Phosphotyrosine protein) phosphatases II 811-1036 2e-16 56.1 In-house 49-269 (314) alignment
Range on Protein: 811-1036
Range on HMM: 49-269/314.0
KQRLPIPLVMDTRVVLkDYGTLFNDDYIHANRVTCShgLQLILSQAPQEangesceSTIESY----------WWTA--KQEKSTQLVM------------
|.| .  | .|.||.| ..   .. |||.|. | .   |. | .|.| |        |....          |      . ..  .||            
knryldilpadnrvil.pglpvsgsdyinasyvdgf..lkfIatqgple.......itvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsr

---------MCDFDEKCpgktnscaryypeSVGESMKFKNLTveckskiaekdfetrelEVKFDGHEPHT--VTHSRLvGWNPlNVQPDTLLFTSLIQKI
          ...|..              .    . ...|                  |. .|.. .    ... |.  .   . .|..  | .... |
LdaAlgKtpllildgng.............neptaadlellk.................eelydpelferlgikylri.pvpD.gsaplledfdeflefi

KN--STTPVMVHCIDGISRSA--AFASMIIGYQlviqslgSVKLEAVVSYIRSQRA-----MAITSALEL
..    .|| ||| .|..|..  ..| ... ..        | || .....|..|       .| . ...
eeadkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqy

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 819-1032 5.7e-16 53.1 In-house 52-278 (301) alignment
Range on Protein: 819-1032
Range on HMM: 52-278/301.0
VMDTRVVLKDYGT--LFNDDYIHANRV-TCSHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGESMKF
. | |..||   .  | . .|| |. .  .|.  . | .|.|        ..|.  .|    ||| ...||... .|.   . ..| .|.|.|  || .|
yddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgp.......mkktlvdfWrliwqekpvsivmvtnlkeg...tkskceqywpnseaeseef

KNLTVECKSKIAEKDFETRELEVKFD-GH---------------EPHTVTHSRLVGWNPLNV--QPDTLLFT---SLIQKIKNSTTPVMVHCIDGISRSA
 ..||. ... .  ||  |.| ||   |                ....|.   .. |    |  .| | |      .... | .  ||.||| |..||| 
gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsG

AFASMIIGYQLViQSLGSVKLEAVVSYIRSQRAMAITS
 . |. ||   . .. | | .  |.  .| ..  |.| 
vYcsvsiglEQc.kaegVVdvfqvtkavrrskpgaVtT

0043147 (Phosphotyrosine protein) phosphatases II 835-1033 9.3e-16 53.5 In-house 5-147 (172) alignment
Range on Protein: 835-1033
Range on HMM: 5-147/172.0
DDYIHANRVTCSHGL-QLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFdekcpgktnscaryypesvgesmkfknltveckskiaekdfet
.|||.|. . ...   ..|  |.|       . .|....|   |... | .|.....                                           
sdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgithivnltel...........................................

releVKFDGHEPHTVTHSRLVGWNPLNVQpDTLLFTSLIQKIKN-----STTPVMVHCIDGISRSAAFASMIIGYqlviqslGSVKLEAVVSYIRSQRAM
    ..   .. ... .   ..|   .|. .. |. .... |..     .  || |||  |..|..... . . .        ...|| .|...|..| .
....lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpg

AITSA
|... 
avqnp

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 822-1039 1.8e-15 51.8 In-house 58-263 (288) alignment
Range on Protein: 822-1039
Range on HMM: 58-263/288.0
TRVVLKDYgtlfNDDYIHANRVTCSHG-LQLILSQAPQeaNGescesTIESYWWTAKQEKSTQLVMMCDFDEKcpGKTNScARYYPESVGESMKFKNLTV
||| |.|      | ||.|| |....   .|| .|||   ||     ||| .|    ..    .||.|.. ||  || .| | |.|  .||..... |  
trvklsdd....pdfyiaanvvssakykrrlicaqaPl..ng.....tieelWkmllesdveyivmlcellek..Gkeks.aeyfPsklGekarigrlct

ECKSKIAE--KDFETRELEVKFDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQlVIQSLGSVKLEAV
  | | |.  |  .   | ..  |.|.  | .  |  |.   |  . | .  |.. .|. . |..||.  |. |..... ..|  . ....   . .. .
vvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililiale.slrlddflgirsl

VSYIRSQRAMAITSALELAFV
..  | .|  ||..     .|
laklreerfkaiqtemqylyv

0051082 (Phosphotyrosine protein) phosphatases II 835-1032 9.8e-15 49.9 In-house 3-138 (151) alignment
Range on Protein: 835-1032
Range on HMM: 3-138/151.0
DDYIHANRVTCShglqLILSQAPQEangescestieSYWWTAKQEKSTQLVMMCDFDEKCpgktnSCARYYPESVgesmkfknltveckskiaekdfetr
.|||....||      |..|..| .            .. . |... .  |.... .|        |..|.||                           
sdyinfsyvtgg....lyrsggpla...........dflellkelgiktivnlrseeerg.....ycpeylpelg.........................

elevkfdghepHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS-TTPVMVHCIDGISRSAAFASMIIGYQLviqslgsVKLEAVVSYIRSQRAMAITS
           ..|.|  ...| . ...  .  . ...... .    || |||  |..|..... ... ..        | ||......|..| .....
...........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqp

PTPc_DSPc_SM00012 947-1040 1.7e-14 49.3 In-house 1-100 (105) alignment
Range on Protein: 947-1040
Range on HMM: 1-100/105.0
TVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTT------PVMVHCIDGISRSAAFASMIIGYQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVD
||.|    ||   .|  ..  ...|....|....      ||.||| .|..|.. |. . | .| . .. ..|... .|...|.||. ....  .  |. 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly





subfamily_PTPN1_pd Subfamily PTPN1 822-1045 2.2e-14 47.9 In-house 47-269 (290) alignment
Range on Protein: 822-1045
Range on HMM: 47-269/290.0
TRVVLKDYGTlfndDYIHANRVTCSH-GLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVG-ESMKFK--N
.|..|..  .    ||| |. |   .   . ||.| |         .|.. .|    ..||  .||.  . ||   ... ||.|.|.    ......  .
srikleradn....dyinaslveleeakrsyiltqGP.......lpntvdhfWqmvWeqkskavvmlnkvvek...eqikcaqywPqgeeekellledtk

LTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST------TPVMVHCIDGISRSAAFAsMIIGYQLVIQSL
|.|.  |.  .. .  | ||..    .| ....|   . |. . |      | ....|...|        |...||  || || .|. ..    . |.  
lkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfc.lvdtclvliekk

GS---VKLEAVVSYIRSQRAMAITSALELAFVDAGIVK
.    |... |.  .|..|   |  |  | |    |..
ddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_PTPRA_pd Subfamily PTPRA 811-1039 2.4e-14 47.9 In-house 61-287 (330) alignment
Range on Protein: 811-1039
Range on HMM: 61-287/330.0
KQRLPIPLVMD-TRVVLKDYGTLFNDDYIHANRVTCSHG-LQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPES
|.|..  |  | .||.|       . ||| |  .   .   . | .| |.|        |.| .|    . ||. .||. ...|.   | . ||.|.|. 
knrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke.......etvedfwrmiweqksativmltelker...keekcaqywPde

vgESMKFKNLTVECKSKIAEKDFETRELEVK--FD---GHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN----STTPVMVHCIDGISRSAAFASM
   .. . |..|| . .   .|.  |.. |.   |    ...  |.   . .|  . |  ..    .|..|.|.    |. |..|||  |. |. .|  .
..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivl

IIGYQlVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
    .  ... . | .  .|. .| ||.  . .     |.
davle.rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefi

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 820-1027 2.8e-14 47.8 In-house 46-239 (267) alignment
Range on Protein: 820-1027
Range on HMM: 46-239/267.0
MDTRVVLKDYgtlfNDDYIHANRVTCS-HGLQLILSQapqeangESCESTIESYWWTAKQEKSTQLVMMCdfdekcPGKTNSCARYYPESVGESMKFKNL
 ||||.|..     ...|| |  | .   . ..|. |       .. . ||  ..   ...| .  |..       .  |.   ...|  .|.. |...|
ddtrvilrtk....eeeyinasyvegyktknafivtq.......dplkntitdfltvihdqkvpvivllt......kvftdnirlfwPPkmgqakkyqdl

TVECKSKIAEKDFETRELEVKFDGHEPHTVTHSRLVGWNP-LNVQPD-TLLFTSLI-QKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLViQSLGSVKL
|||   .  |.|..   ||.||     | ||      ||   | .|    ||  |  ....|   |..|.| ||. || .|  .    . . .  | ...
tvehslekeendyqiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlera.ktegvsdi

EAVVSYIRSQRA
   .  ||||| 
fdflrkirsqri

subfamily_PTPRK_pd Subfamily PTPRK 807-1039 3.7e-14 47.3 In-house 42-269 (314) alignment
Range on Protein: 807-1039
Range on HMM: 42-269/314.0
SEQMKQRLP-IPLVMDTRVVLKDYGTLFNDDYIHANRVTCSH-GLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEKCpgkTNSCARY
 ...|.|   |     .||.|.      . ||| |. .   .   . |  | |        ..|.. .|    .|... .||. .. |.       | .|
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPl.......qetvkdfWrlvydencasivmltelvevg...rvkClky

YPEsvgESMKFKNLTVECKSKIAEKDFETRELEVKF---DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNST----TPVMVHCIDGISRSAAFA
.||   ........ ||. .  ..... .| . |.      .| ..| . . .||   .|      . .|....|.|.     ...|||  |  |. .| 
WPe...dtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfi

SMIIGYQLvIQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
 . |  .. |.  | | .  .|  .||..   .       |.
aidivldm.ieregvvdvfnavktlrsrkvnmveteeqykfi

0046846 (Phosphotyrosine protein) phosphatases II 833-1038 3.7e-14 48.4 In-house 10-164 (176) alignment
Range on Protein: 833-1038
Range on HMM: 10-164/176.0
FNDDYIHANRVTCSHglqlilsqapQEANGESCESTIESYWWTAKQEKSTQLVMMCDFDEKCPGKtnsCARYYPESVGESMkfknltveckskiaekdfe
.. |||.|| . .|.            |  .....|.....   |... | .|....  |.   |   |..|.||  ....                   
ldldyinanlilgsr..........piatqgplprtladflemlkelgitavvnlteevelgrlk...cpnywpeleklgi...................

trelevkfdghephTVTHSRLVGWNPLNVqPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIigyqlVIQSLGSVKLEAVVSYIRSQRA-MAIT
              .. |   .  .. .   . | .  .|..  ..  || |||  ||.|..... .       ...   ...| .....|.||  .|..
..............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay.....llelekglsveealalvreqRplgavq

SALELAF
.   . |
tpeQyrf

0036282 (Phosphotyrosine protein) phosphatases II 835-1033 6.6e-14 47.4 In-house 2-156 (174) alignment
Range on Protein: 835-1033
Range on HMM: 2-156/174.0
DDYIHANRVTCSHGL-QLILSQAPQEangescestiesYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPEsvgesmkfknltveckskiaekdfet
.|||.|. .  |. .  ||..|.| .            .|   |....| .||...  |    .   | .|.||                          
sdyinaspldlsyitprliagqgpla............fwemlkelgittvvmlleeke...lglykcinywpe..........................

relevkFDGHEPHTVTHSRLVGWNPLNVQPDTLlFTSLIQKIKNS-----TTPVMVHCIDGISRSAAFASMIIGYQLVIqsLGSVKLEAVVSYIRSQRAM
      .  .. ... .   ..|   .| ...  . .... ...        || |||  |..|..... . . ... .   . |.  ..|  .|.|| .
......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpg

AITSA
.... 
mvqtp

subfamily_eak_pd Subfamily eak 862-993 1.7e-13 44.7 In-house 99-225 (332) alignment
Range on Protein: 862-993
Range on HMM: 99-225/332.0
GESCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPESVGESMKFKNLTVECKSKIAEKDFETRELEVKfDGHEPHTVTHSRLVGWNPLNV
| . |. .  .|    ..||  .|.. .  |.   | .   .|.|.   | .||  | ||.|. . .. .||| ||..  | | | | | .. ||  ...
Giasedkvfafwqmvleqkspaivqlledvel...kleksdkyfpdktreelkfGildverkefvkrniletrllels.kGnethrvlhykvfGwtettl

qPDTLLFTSLIQKIKNSTTPVMVHCIDGISRS
 |    | .| . .|.  .. ..   . . .|
.pkyedflalrkvmkevGvlllivmksallss

subfamily_PTPN14_pd Subfamily PTPN14 820-1046 5e-13 43.7 In-house 62-295 (300) alignment
Range on Protein: 820-1046
Range on HMM: 62-295/300.0
MDTRVVLKDYGTLfNDDYIHANRVTCSHGLQ---LILSQAPQeangescESTIESyWWTAKQEKSTQLVMMCDfDEKCPGKTNsCARYYPES--VGESMK
 |.|| |.      ...|| | ..  | | .    | .|.|.       | |..  .|    |. .||..|   .|.  ||.  . .|.|..    ....
ednrvelsptken.stgyinassikvsvggkersyivaqgPl.......eltvqd.fWqmvWeqgvqlivmlt.eeeedgkek.sfkyfPkleskkktve

FKNLTVECKSKIAEKDFETRELEVKF-DGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIK-------------NSTTPVMVHCIDGISRSAafasMI
|..  |  | .   . . |. |..|.   .|  || | . . |   .| .|   | | .....             .|  ||.||| .|. |.     ..
fgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG....vl

IGYQLVIQSL---GSVKLEAVVSYIRSQRAMAITSALELAFVDAGIVKL
|  .|.|..|    ..... |.. .| || . . .     ||   ..| 
ilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky

0049260 (Phosphotyrosine protein) phosphatases II 867-1033 1e-12 43.5 In-house 20-136 (152) alignment
Range on Protein: 867-1033
Range on HMM: 20-136/152.0
STIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYpesvgesmkfknltveckskiaekdfetrelevkfdghephtvtHSRLVGWNPLNVQPDTL
 |....|   |. . | .||.....|    .   |..|.                                            .   . |   .|.... 
ntladfwrmlkelgittivmltelle...lgklkceqyi............................................qylhlpwpDhgvpdlsq

LFTSLIQKI----KNSTTPVMVHCIDGISRSAAFASMIIGYqlviqslGSVKLEAVVSYIRSQRAMAITSA
|.  |.. |    ...  || |||  |..|..... . . .         |.|| .|...|..| .|... 
lllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnp

subfamily_PTPRN_pd Subfamily PTPRN 811-1040 1.4e-12 42.0 In-house 59-285 (297) alignment
Range on Protein: 811-1040
Range on HMM: 59-285/297.0
KQRLPIPLV-MDTRVVLKDYGTLFNDDYIHANRVTCSHGLQL--ILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPE
|.|    |   ..|| ||.  .  ..||| |  .. .   .   | .|.|         ||. ..| .  .. .. .|...  .|.    .. |.||.|.
knrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgp.......lastvadfwqmvweqGvvvivnltrleee...gvkqckrywpd

SVGESMKFKNLTVeCKSKIAEKDFETRELEVK-FDGHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIK----NSTTPVMVHCIDGISRSAAFASMIIG
   |  .. .. .    .|  .|.  | . .| .. .|  |||    . |.  .| . .  .  . .|.       ..|..||| ||  |. ..  . . 
eGsevyhiyevhl.vsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlv

YQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFVD
 . ... .  . . | . ..| ||.  . .  .. |. 
lnrllkGvkeidiaatlehlrdqrpglvktkdqfefal

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 833-1039 4e-12 40.2 In-house 59-280 (302) alignment
Range on Protein: 833-1039
Range on HMM: 59-280/302.0
FNDDYIHANRVTCsHGLQLILSQAPQEANG----E------SCESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESVGESMKFKNLTVEC
|..|.| || ..   ... |..| | .       .         ||.| .|   .| . .  | .|.| |   .. . || || . ||. .||.. ||. 
fkndfinanvlkl.deikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfve...deekkcaeyysdkvggelkfgrytvkt

K---SKIA----EKDFETRELEVKFD---GHEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSLgS
.    ...     |.|    .|.| .    . ..||      .|       ..     ...  .   . |.|||  |. |. .. ..  | ||  .    
vsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkk.v

VKLEAVVSYIRSQRAMAITSALELAFV
 .|  .|  .|. |  |. ..  | ..
tdllsivlpvrqcryGavqdeqqliyl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 822-1045 3.9e-11 38.0 In-house 40-253 (284) alignment
Range on Protein: 822-1045
Range on HMM: 40-253/284.0
TRVVLKDYGTLFNDDYIHANRVTCSHGL-QLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCdfdekcpgkTNSCARYYPESVGESMKFKNLTV
..| |.        ||| |  .|      . | .| |.       . |.. .|    . ... .|..           . |..|.|  . .  .  .. |
nvvklerliGeefsdyinasfitGyqrkdkyiatqGPl.......dntladfWrmiweyncstivllt.........kdkcsqywplkivikeerfkvkv

ECKSKIAEkdFETRELEVKFDGHEP--HTVTHSRLVGWNPLNVQPDTLLFTSLIQK------IKNSTTPVMVHCIDGISRSAAFASMIIGYQlVIQSLGS
.  .. .|  .  |..|.  ||.|    ...   . ||    |   .  .  |..|       .|  ....|||  |. |. ..  . .  .  ..    
dsveesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlld.rmkeekq

VKLEAVVSYIRSQRAMAITSALELAFVDAGIVK
| .  .|  .| ||   . .  .  |. . ...
vdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 866-1039 4.5e-11 37.2 In-house 102-271 (315) alignment
Range on Protein: 866-1039
Range on HMM: 102-271/315.0
ESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESvgeSMKFKNLTVECKSKIAEKDFETRELEVKFdGHEPHTVTHSRLVGWNPLNVQPDT
 .... .|    .|. ...||. .  |   |. . . .|.|.     . . ..||  ||.  ....  | | | | | . ..|   ..  |   .|   |
vasvkdfwrlvfeedigkivmltnlve...gekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvf.gdnirevvqlhytswpdmgvpkyt

LLFTSLIQKIK----NSTTPVMVHCIDGISRSAAFASMIIGYQlVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
. .  ||...|    || ....||| .|. |. .| ..    .  ..    . .  ..  .|..|  .. .| .  |.
iplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavld.qaeaenaidvynfitgvrqnrikmvqvaeqyqfi

subfamily_PTPRG_pd Subfamily PTPRG 820-1044 6.2e-11 36.2 In-house 60-284 (563) alignment
Range on Protein: 820-1044
Range on HMM: 60-284/563.0
MDTRVVLKDYGTLFND-DYIHANRVTC-SHGLQLILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEKcpgKTNSCARYYPEsvGESMKFKN
  .|| |..     .. ||| || .    .. . | .| |        ..|.. .|    ..... .||. .. |.   . . | .|.|.   ||.....
drsRvklsplpgkkkklDYinAnyidGyqkskafiatqgp.......lkdtfddFWrmiWeqnvaiivmitnlver...grrkcdvYWPk..desetyga

LTVECKSKI-----AEKDFETRELEVKFDGH--EPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKN----STTPVMVHCIDGISRSAAFASMIIgYQLV
|.|  ...      ... .  ..|..|   .  . ..|.. .   |   .|   .|   . ..| .      . |..|||  |..|.  .  .       
lqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldt.llkq

IQSLGSVKLEAVVSYIRSQRAMAITSALELAFVDAGIV
||.  .| .  ..  ||.|| . ...  .  |.   ..
iqqenavnvfgflkhiraqRnflvqteEqYiflhdall

0048076 (Phosphotyrosine protein) phosphatases II 946-1032 7.3e-11 37.4 In-house 45-128 (145) alignment
Range on Protein: 946-1032
Range on HMM: 45-128/145.0
HTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS---TTPVMVHCIDGISRSAAFASMIIGYQlviqsLGsVKLEAVVSYIRSQRAMAITS
.....   ..|   .|.... |. .... |..      || |||  |..|..... . . ..     || | || .. ..|||| .|...
rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lg.vsleealelvrsqrpgavpn

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 822-1045 8.4e-11 36.7 In-house 76-289 (319) alignment
Range on Protein: 822-1045
Range on HMM: 76-289/319.0
TRVVLKDYGTLFNDDYIHANRVTCSHGL-QLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCdfdekcpgkTNSCARYYPESVGESMKFKNLTV
..| |.        ||| |  ||      . | .| |.       . |.. .|    . ... .|..           . |..|.|  . .  .  .. |
nvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl.......dntladfWrmiweyncstivllt.........kdkcsqywplkivikeerfkvkv

ECKSKIAEkdFETRELEVKFDGHEP--HTVTHSRLVGWNPLNVQPDTLLFTSLIQK------IKNSTTPVMVHCIDGISRSAAFASMIIGYQlVIQSLGS
.   . ||  .  |..|.  ||.|     .|   . ||    |   .  .  |..|       .|  ....|||  |. |. ..  . .  .  ..    
dsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlld.rmkeekq

VKLEAVVSYIRSQRAMAITSALELAFVDAGIVK
| .  .|  .| ||   . .  .  |. . ...
vdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_ptpA1_pd Subfamily ptpA1 817-1002 1.2e-10 35.7 In-house 57-252 (418) alignment
Range on Protein: 817-1002
Range on HMM: 57-252/418.0
PLVMDTRVVLKDYGTLFNDDYIHANRVTCSHGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCDFDEKCPGKtnsCARYYPESVGES----
  |  ||| ||        ||| || .  ..  |.| .| |          ||  .|    ...   .||.    |.|  |   | ||.|| .|      
lpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgpl.......pntiadfwrmvwenrcriivmlsresencrik...cdrywpeqiggeqfsi

-----MKFKNLTVECKSKIA--EKDFETRELEVKFDGhEPHTVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS----------TTPVMVHCIDGISRSAA
       |   .||    |   |..  ||.. . |.| | . .|. .  ||   |.   |  |  |.. | |             |..|||  |. |. .
ygngnevfgtysvelveviqdpereiitrnirltfeg.etrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

FASMIIG
|.. .| 
fctavim

0048179 (Phosphotyrosine protein) phosphatases II 944-1033 1.5e-10 36.5 In-house 48-131 (144) alignment
Range on Protein: 944-1033
Range on HMM: 48-131/144.0
EphtVTHSRLVGWNPLNVQPDTLLFTSLIQKIKNS---TTPVMVHCIDGISRSAAFASMIIGYqlviqSLGsVKLEAVVSYIRSQRAMAITSA
|   ...   ..|   .| ... |. .... |..      || |||  |..|..... . . .      || . || .. ..||.| .|... 
e...giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klg.lsleealalvrsrrpgavpnp

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 820-961 2.4e-10 34.7 In-house 46-179 (297) alignment
Range on Protein: 820-961
Range on HMM: 46-179/297.0
MDTRVVLKdyGTLFNDDYIHANRVTC---SHGLQLILSQAPQEAngescesTIESYWWTAKQEKSTQLVMMCDFDEKcpGkTNSCARYYPESVGESMKFK
 |||| |.  ..  . ||| |. |.     . |. ||.| | .|       |.. .|    ..    .||.. . |   |  . || |.|..|.| .|  
ddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsa.......tvddfwtlvaeqdvrvivmvaklqed..G.rdkcapywpsvvqerlkag

NLTVECKSKIAEKdFET---RELEVKFDgHEPHTVTHSRLVGWNPLNV
.. ||  |. ... |..    ||.. .   |   |.| . ..|    |
dvvveflsstsde.fdrviltelqliyr.sesrvvrhvqflswpdhGv

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 806-1037 1.4e-09 31.8 In-house 49-275 (302) alignment
Range on Protein: 806-1037
Range on HMM: 49-275/302.0
KSEQMKQRLPIPLVMDTRVVLKDYGtlfNDDYIHANRVTCS-HGLQLILSQAPQEangeSCESTIESYWWTAKQEKSTQLVMMCDFDEkCpgkTNSCARY
|..  |.. .   ..|...| ..     .|.|..| .|.    . ..||.| |.     . |. .|..|  . ||| ...|..   .| .   ...   .
kknlkknqsedvpildsnlvkleae...pdsyvnaskvevPeltrsiilaQlpkv....dsedsveeFWrmvfqekivsvvilvgeee.l...kktlsel

YPESVGESMKFKNLTVECKSkIAEKDFET--RELEVKFDGHEPHTVTH-SRLVGWNPLNVQPDTLLFTSLIQKI----KNSTTPVMVHCIDGISRSAAFA
.|.  |.  ..... |  .  . ... |.    .||  .|     ..    |  |.. .|       .  ..|.     ... ....    |. | .|| 
fpkksgdykeygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafl

SMIIGYQLVIQSlGSVKLEAVVSYIRSQRAMAITSALELA
....  . . ..   .. . .|  |||||. |. |.   .
tlavaveklqkg.kepnikeivksiRsqRpravdslkQyv

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 821-999 8.1e-09 30.0 In-house 17-192 (237) alignment
Range on Protein: 821-999
Range on HMM: 17-192/237.0
DTRVVLKDYGTlfNDDYIHANRVTCSHGLQ--LILSQAPqeangesCESTIESYWWTAKQEKSTQLVMMCDFDEkcpGKTNSCARYYPESvGESMKFKNL
 .|||||  |.  . ||| |. .    |     | .| |        ||. . .|    ||| . .||.  . |   |.   | .|.|..  .   .  |
hsrvvlkgags..gsdyinatylkgfdgtpkkyiaaqgp.......lesscddfwqmvwqekcsvivmltglie...gnelkchkywpst.dqpaaygvl

TVECKSKIAEKDFETRELEVKF--DGHEPHTVTHSRLVGWNPLNVQPDTLL---F-TSLIQKIKN--STTPVMVHCIDGISRSAAFASM
||  | | .  |.  | | .      .|   .   ..  |    |   |     |   .|.. .    ..| ..||  |. |.. |  .
tvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvi

subfamily_CG7180_pd Subfamily CG7180 821-1035 1e-07 25.9 In-house 56-278 (296) alignment
Range on Protein: 821-1035
Range on HMM: 56-278/296.0
DTRVVLKDYGTLFNDDYIHANRVTC-SHGLQLILSQAPQeangescESTIESYWWTAKQEKSTQLVMMCdfdeKCPGKTNSCARYYPESVgeSMKFKNLT
 .||||.  .   ..||| |  |    .  . |  .||.       ..|....|    .|..  .|...    | .  .. .  |.|.      ..... 
ynRvvLekldGeeksdYinavyvdsflkkkeyivteapk.......ketvdefWrlvydeeisavvvLt....ktfdfakmypsywpnks..keqygeif

VECKSKIAEKDFETRELEVKFD-----------GHEPHTVTHSRLVGWNPLNVQPDT-LL---FT----SLIQKI--KNSTTPVMVHCIDGISRSAAFAS
||  ..    ....|.. ..               |  .|.. .|  |.  .  |        .     ....|.  .. . ||.|.. || ||| .. .
veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyla

MIIGYQLVIQSlGSVKLEAVVSYIRSQRAMAITSALE
. .  .||..  . | .   |  .| .|   . .  |
idanlelveke.eevdvFeavktlrrsRpqLvenvee

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 836-1000 6.9e-07 23.3 In-house 68-233 (312) alignment
Range on Protein: 836-1000
Range on HMM: 68-233/312.0
DYIHANRVT-CSHGLQLILSQAPQEangesceSTIESYWWTAKQEKSTQLVMMCDFDEKCpgkTNSCARYYPESVGES--MKFKNLTVECKS-KI--AEK
 ||||| |  |..  ... .|.| |       .|.  .|  |    || ....| | |     .. ||.|  . ||       .  |  |   .|    |
fyihanfvkictkperfvctqgple.......ntcthfwqlalslgstsiillcgfvedg...sekcakyisdivgfvdledhrvyteycteieiggksk

DFET-R--ELEVKFDGHEPhTVTHSRLVGWNPLNVqPDTL-LFTSLIQKIKNSTTPVMVHCIDGISRSAAFA---SMI
|  | |   . ||  | |   . | .   |    . ||.      |.  .|.   ||. ||  |. |. ..|   |||
dkithrvlkvvvkatgqes.klnhyqwaswpdhgm.pdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmi

subfamily_CG42327_pd Subfamily CG42327 798-976 7.2e-07 23.2 In-house 23-191 (319) alignment
Range on Protein: 798-976
Range on HMM: 23-191/319.0
EVPGREALKSEQMkQRLPIPlvmDTRVVLKDYGTLFNDDYIHANRVTCSHGlqlilSQAPQEANGESCESTIESYWWTAKQEKSTQLVMMCDFDEKCpgk
|||     ||  . . .|.|   .|||||.  |   .| |..|. |   .      ...   |   | |..  ..| |  . .|  .| ..|  |.    
evPvtskdksrvi.nvvPlP...etrvvlqrigdddkdeyldasyvrGydd.....apnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselG...

TNSCARYYPESVGE--SMKFKNLTVECKSKIAEKDFETRELEVK-FDGHEPHTVTHSRLvGWNPLNVQPDTLLFTSLIQKIK
 . ||.|.| . .      . .. |  | . ... . .  | .|  |..|   .||     |   .|  .   . ... ...
ikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

DSPc Dual specificity phosphatase, catalytic domain 969-1027 1.3e-06 23.3 Pfam-A 63-115 (133) alignment
Range on Protein: 969-1027
Range on HMM: 63-115/133.0
TSLIQKIKNSTTPVMVHCIDGISRSAAfasMIIGYQLVIQSLgsvKLEAVVSYIRSQRA
.. |.|....   |.|||  ||||||.   .|| | .  ..|   .|.  .......| 
vefiekaeqkgkkvlVHCqaGisRSat...liiaYlmktknl...slneAyefvkerrs

DSPc Dual specificity phosphatase, catalytic domain 969-1027 1.3e-06 23.3 In-house 63-115 (133) alignment
Range on Protein: 969-1027
Range on HMM: 63-115/133.0
TSLIQKIKNSTTPVMVHCIDGISRSAAfasMIIGYQLVIQSLgsvKLEAVVSYIRSQRA
.. |.|....   |.|||  ||||||.   .|| | .  ..|   .|.  .......| 
vefiekaeqkgkkvlVHCqaGisRSat...liiaYlmktknl...slneAyefvkerrs

PTPc_motif_SM00404 969-1009 1.5e-06 23.2 In-house 70-107 (140) alignment
Range on Protein: 969-1009
Range on HMM: 70-107/140.0
TSLIQKIKNSTTPVMVHCIDGISRSAAFasmIIGYQLVIQS
.. |...... . |.|||  |.||||..   || | .  ..
ldfienaekkggkvlVHCqaGvSRSatl...iiaYlmryrq

subfamily_CG42327_pd Subfamily CG42327 976-1039 2e-06 21.7 In-house 244-307 (319) alignment
Range on Protein: 976-1039
Range on HMM: 244-307/319.0
KNSTTPVMVHCIDGISRSAAFASMIIGYQLVIQSLGSVKLEAVVSYIRSQRAMAITSALELAFV
..|  |..||| ||. |.    .  |  . . .|  || .  .||..| .|| |. .    .|.
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefi

subfamily_Slingshot_pd Subfamily Slingshot 971-1028 3e-06 20.7 In-house 88-139 (169) alignment
Range on Protein: 971-1028
Range on HMM: 88-139/169.0
LIQKIKNSTTPVMVHCIDGISRSAafaSMIIGYQLVIQslgSVKLEAVVSYIRSQRAM
 |.| |.. . |.|||  |.||||   | .| | .      ...||  ..|....| .
fiekakkkgskvlvhckmGvsrsa...stviayamkey...glsleealeyvkerrsv

subfamily_DSP8_pd Subfamily DSP8 970-1032 5e-06 20.2 In-house 84-139 (159) alignment
Range on Protein: 970-1032
Range on HMM: 84-139/159.0
SLIQKIKNSTTPVMVHCIDGISRSAafaSMIIGYqlVIQSLgSVKLEAVVSYIRSQRaMAITS
. |.|.|.. . |.||.  ||||||   ...|.|  ... | ...|.    .....|  .|  
efidkaksengrvlvhvlaGisrsa...tvaiay..imktl.emsldeayrfvkekr.ptisp