Gene sdf-9 in Caenorhabditis elegans

Synonym: CELE_Y44A6D.4, sdf-9

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily eak
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP179_AA protein Get Run
CeleP179_AA_9-286 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_eak_pd Subfamily eak 5-312 1.5e-181 597.0 In-house 26-332 (332) alignment 
Range on Protein: 5-312
Range on HMM: 26-332/332.0
SIRSNIVHKLDDNQPLLSERVTARLEAVNRNrVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQF
. | |||..|||.|.|||...|||||||||| ||||||..||.||||.|.|||.|||||||.|||.||.|||||||.|||||||||||||||.||.|.|.
nqrinivadlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivql

ADNVEEKLEHYDKYFPDKG-DVWSYGHLQVERKSYaIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGALNMINPASALF
...||.|||..|||||||. .....|.|.||||.. .......||...|.||||||||||..||||||||.|...||||||||||..|.|..|...|||.
ledvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksall

RSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPLIAYS
.||...||||||||||||||||||.|||.|||||||||.||.||.|||||||||.|.|..|||.|.|||.||||||.|||||||||.|..|.|..|.||.
sstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleaya

ESCFVKWSS
||..||.||
esvrvkdss
0036941 (Phosphotyrosine protein) phosphatases II 10-300 3.2e-50 166.5 In-house 18-292 (297) alignment 
Range on Protein: 10-300
Range on HMM: 18-292/297.0
IVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPsmlNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
  ..|.....| | .|....| ...||   |.|  .  |.|..   . ..|||||.... |...|.|.|  | .. |  ||.||.||....|. . . ||
efeellpllllgslsvallpenleknRykdilpydhtRVkldd...egsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve

EKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIH-QGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNminpasalfr
   | ...|.|.. |... ||...|. .|. ..  .....|.. . .  ..|...| || ..|| .  .|  ....|.. . ...  .|           
lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll..........

stmrryihtPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGK-KTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPLI
         |..   .. .  | .|.|.|...||.......| |.. ... ... | ...| ..|.   .  |.|||.|..|..........|. |.
.........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvll
DSPc_SM00195 13-285 3.4e-49 162.9 In-house 8-262 (263) alignment 
Range on Protein: 13-285
Range on HMM: 8-262/263.0
KLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
||.....  . . ... . ...||  .|.| ..  |.|...   . . ||||. .....  .|||.|  | .. |  ||.||.|.....|. . ...|..
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

LEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstm
 |. |.|.|.. |. . .|...|. ... ... ....|.. |.| .  ||..| .. . .|..  .|  ....|.| ...| .   .             
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.............

rryihtppSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
        |   ....  | .|.|.||.||.... .. .|.  ....... . .. |...|    ...|||||.|.|.
........sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 13-285 3.4e-49 162.9 In-house 8-262 (263) alignment 
Range on Protein: 13-285
Range on HMM: 8-262/263.0
KLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
||.....  . . ... . ...||  .|.| ..  |.|...   . . ||||. .....  .|||.|  | .. |  ||.||.|.....|. . ...|..
kleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeeng

LEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstm
 |. |.|.|.. |. . .|...|. ... ... ....|.. |.| .  ||..| .. . .|..  .|  ....|.| ...| .   .             
kekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.............

rryihtppSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
        |   ....  | .|.|.||.||.... .. .|.  ....... . .. |...|    ...|||||.|.|.
........sgpivVhCsaGvgRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0040438 (Phosphotyrosine protein) phosphatases II 11-320 6.4e-49 162.3 In-house 24-310 (317) alignment 
Range on Protein: 11-320
Range on HMM: 24-310/317.0
VHKLDDNQPLlSERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
 ..|.....  . .|....|  ..|| . |.|  .  |.|.| .  . ..|||||.... . ..|.|.|. | .. |. ||.|| ||.. .|. . . .|
fedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtelee

EKLEHYDKYFPDkGDVWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGalnminpasalfrst
 . | ...|.|. |... ||...|. .|.    .... |.. .   ...|...| ||   ||.. ..|  ....|.. . ...                 
lgrekcaqYwpl.getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal...............

mrryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRFQDFKEPlIAYSESC
       .|.   .. .  | .|.|.|....|.....  .|.. ..||. . . ...| ..|.   .  |.|.|.|.||.|....  . . .  .. . .
......edpggpvlVHCsaGvgRtGtfiaaylmleql..ekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselk.lkllkll

FVKWSSMDKEIEKF
 ... ...|..|| 
iplalddvklkeke
0051299 (Phosphotyrosine protein) phosphatases II 14-285 1.3e-45 151.5 In-house 32-286 (288) alignment 
Range on Protein: 14-285
Range on HMM: 32-286/288.0
LDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKL
| ...| |. ..... | ...|| . |.|  .  |.|..    . ..|||||.... . ..|.|.|  | .. |  ||.|| ||....|. . . || . 
llsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgr

EHYDKYFPDkGDVWSYGHLQVERKSYAIhQGNFHTRNFILR------KGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGAlnminpasalfrs
| ...|.|. |... ||...|. .|. . .... .|.....      ...|...| || ...| .  .|  ....|.. . ...  |             
ekcaqYwpl.ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.............

tmrryihtPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
        ...   .. .  | .|.|.|...|||..... .  .  .|.... . ...| ..|.   .  |.|||.|.||
........sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 22-289 1.4e-45 151.2 In-house 19-278 (284) alignment 
Range on Protein: 22-289
Range on HMM: 19-278/284.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFS-----DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEH
| .|....| ...|| . |.|  .  |.|..     . ..|||||....      .. .|.|.|  | .. |  ||.||.||....|. . . || . | 
slsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrek

YDKYFPDKGDVWSYGHLQVERKSYAIhQGNFHTRNFILRK---GNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALnminpasalfrstmrry
...|.|..|.|. ||...|. .|. . .... .|.. |..   ..|...| || ...| .  .|  ..|.|.. . ...                     
caqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.................

ihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKK-TNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
  .|..   .. .  | .|.|.|...|||..... .. .  ..|.... . . .| ..|    .  |.|||.|.||....
..lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
0050432 (Phosphotyrosine protein) phosphatases II 12-288 1.4e-44 148.0 In-house 49-302 (308) alignment 
Range on Protein: 12-288
Range on HMM: 49-302/308.0
HKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLtpSmlNRDGYINASLMEFS--DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
..| ...|||. .|... | ...|| . |.|  .  |.|  .  . ..|||||.. .   .. .|.|.|  | .. |  ||.|| ||....|. . . ||
eellsvkplleysvallpenkdkNrykdilpydhsRVkl..d..egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklve

EKLEHYDKYFPDK--GDVWSYGHLQVERKSYAIhQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGalnmiNPasalfr
 . | ...|.|..  |... ||...|. .|. . .... .|...|..  ..|...| ||   .| .  .|  ....|.. . ....      ..      
ngrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pg......

stmrryihtppsFAPIIQSARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
               .. .  | .|.|.|...|||..... .  .  .|.... | ...| ..|.   .. |.|.|.|.||...
............gpivVHCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
0039614 (Phosphotyrosine protein) phosphatases II 22-289 2.5e-43 144.0 In-house 47-293 (297) alignment 
Range on Protein: 22-289
Range on HMM: 47-293/297.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFSDV-GQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLeHYDKY
. ..... | ...|| . |.|  .  |.|.| .   . . |||||.... |. ..|.|.|. |... |  ||.|| ||....|.   . || .  ....|
dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqy

FPDKGDvwSYGHLQVERKSYAIhQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstmrryihtPPSF
.|..|.   ||...|. ...    .....|.. .....|.. | || ..|| . ..| .....| . . ...  | .                   |.. 
wpeegg..tygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael...................pkgg

APIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
  .. .  | .|.|.|....|.....  .|.  ..|.. . . . .| ..|.   .  |.|.|.|..|.|..
pvlVHCsaGvgRtGtfiaaylmleql..ekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
0047943 (Phosphotyrosine protein) phosphatases II 14-285 4.6e-43 143.0 In-house 21-272 (273) alignment 
Range on Protein: 14-285
Range on HMM: 21-272/273.0
LDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLtpsMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLE
| ...|||. .|... |  ..||   |.|  .  |.|     . ..|||||.... ....|.|.|  | .. |  ||.|| ||....|.   . || . |
llslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgre

HYDKYFPDKGD--VWSYGHLQVERKSYAIhQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGAlnminpasalfrstmr
 ...|.|..|.  .. ||...|. .|. .  ... .|...|..   .|.. | || ..|| .  .|  ....| . ...... .                
kcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale................

ryiHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
   ..| .   .. .  | .|.|.|...|||....  .|..  .|.... . . .| ..|.   .  |.|||.|.||
...alpsngpvvVHCsaGvgRtgtfialdllldql..ekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 20-287 7.6e-43 142.8 In-house 44-306 (307) alignment 
Range on Protein: 20-287
Range on HMM: 44-306/307.0
LLSERVTARLEAVNRNRVVKIVPQHRYNVRLTP--SMLNRDGYINASLM--------EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
| . ......|  ..|| . |.|  .  |.|..  ..|. ..||||| .        .. |...|.|.|  | .. |  ||.|. ||.. .|.   . ||
lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelve

EKLEHYDKYFPDKGDVWSYGHLQVERKSYAIhQGNFHTRNFILR---KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALnminpasalfrs
 . | ...|.||.|... ||...|. .|. . ..... |.. .    . .|...| ||   || ....|  ....|.. . ...  .             
lgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkalee............

tmrryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNL-YSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
       .|..   .. .  | .|.|.|....|..|...  .| | ..... . . . .| ..|.   .  |.|||.|..||.
.......lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
0043336 (Phosphotyrosine protein) phosphatases II 13-285 5.4e-42 139.5 In-house 28-277 (278) alignment 
Range on Protein: 13-285
Range on HMM: 28-277/278.0
KLDDNQPlLSERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
.|.....  . ......| ...|| . |.|  .  |.|.. .  . ..|||||.... .|..|.|.|. |... |  ||.|| |....||.   . || .
ellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelg

LEHYDKYFPdkGDVWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGalnminpasalfrstmr
 . ...|.|  |... ||...|. ...   ......|.. .   . .|.. |.|.  .|| . ..|  ....| . |....                   
rvkcaqYwp..ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal.................

ryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
     ... . .. .  | .|.|.|....||....  .|.  ...|. . . ...| ..|.   .  |.|||.|.||
....edsngpvlVHCsaGvgRTGtfialyllleql..ekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0040439 (Phosphotyrosine protein) phosphatases II 26-286 8.8e-41 135.5 In-house 6-247 (249) alignment 
Range on Protein: 26-286
Range on HMM: 6-247/249.0
TARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkGD
. ..| ...|| . |.| ..  |.|.. . |. ..|||||...........|.|. | .. | .||.|. |... .|. . . || . |....|.|. |.
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.gg

VWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTP-IMQDFLALRKVMKDTGALNminpasalfrstmrryihtPPSFAPII
.. ||...|. .|. .  .....|.. |   . .|...|||. ...| .. .|  ..|.|.. . ...  . .                   |..   ..
sleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...................pkggpvlV

QSARGSSRAGAFVVIDLLIRMIDgkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
 .  | .|.|.|....|......  |.. ...|. . . ...| ..|.   .  |.|||.|..||
HCsaGvgRtGtfiaaylmleqle..kelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 27-289 1.2e-39 131.8 In-house 29-276 (278) alignment 
Range on Protein: 27-289
Range on HMM: 29-276/278.0
ARLEAVNRNRVVKIVPQHRYNVRltpsmlnrdGYINASLMEFSdvGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkGDVW
 .|. ...|| . |.|  .  |.         .|||||....   ..|.|.|  | .. | .||.|. |.....|.  .. || . |....|.|. |...
lylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe.ggsl

SYGHLQVERKSYAIHqGNFHTRNFILR------KGNETHRVLHFTVFGWTETTTPIMQ---DFLALRKVMKDTGALnminpasaLFRSTMRRYIHTPPSF
 ||...|. .|. .. .....| ....      ...|.. | |.  ..| . ..| .     || | . ...  .|        |.. .. .... ... 
tygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl........laslllsslllldsgg

APIIQSARGSSRAGAFVVIDLLIRMIdgkkTNLYSVEDLIVKCKHMRIH-CVPVALHHSFIYEAVLDYLLRRN
  ..    | .|.|..|...|.....     . ..... . . . .| . .|.   .  |.||..|..|||..
pvlVHCsaGvgRtGtlvaaylmlell....eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
0042113 (Phosphotyrosine protein) phosphatases II 25-285 1.5e-39 131.3 In-house 3-243 (245) alignment 
Range on Protein: 25-285
Range on HMM: 3-243/245.0
VTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkG
|....| ...|| . |.| ..  |.|.|   .  ..|||||.. .... .|.|.|. |... | .||.|. |... ||. . . .| . . ...|.|. |
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

DVWSYGHLQVERKSYAIhQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKdtgalnminpasalfrstmrRYIHTPPSFAPI
... ||...|. .|. .  .....|.. .   . .|.. |.|.  ..| . ..|  ....| . . ..                    .... ...   .
esltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvr....................kalaedsngpvl

IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
. .  | .|.|.|....|.....  .|.  .|.|. . . . .| ..|.   .  |.|||.|..|
VHCsaGvgRtGtfiaaylmleql..ekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
Y_phosphatase Protein-tyrosine phosphatase 33-282 4.7e-36 119.7 Pfam-A 3-234 (235) alignment 
Range on Protein: 33-282
Range on HMM: 3-234/235.0
NRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWSYGHL
..||  .|.|  .  |.|. |  . | ||||. ..  .  .|.|.|  | .. .  ||.||..... .|.. ....|.. |....|.| ....  .||..
kknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

QVERK-SYAIHQGNFHTRNFILRKGNET---HRVLHFTVFGWTETTTPimQDFLALRKVMKD----TgalnminpasalfrstmrryihTPPSFAPIIQS
.|| | .   .. .. .|.. |.| .|    ..| .. . .|.. ..|  ..  .| .....    .                      .. |   ....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk......................eaksgpvvVhC

ARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVL
  |..|.| ||..|.|..... ...   .| ... . .. |...|  .    |.|.|.|
saGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 33-282 4.7e-36 119.7 In-house 3-234 (235) alignment 
Range on Protein: 33-282
Range on HMM: 3-234/235.0
NRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWSYGHL
..||  .|.|  .  |.|. |  . | ||||. ..  .  .|.|.|  | .. .  ||.||..... .|.. ....|.. |....|.| ....  .||..
kknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

QVERK-SYAIHQGNFHTRNFILRKGNET---HRVLHFTVFGWTETTTPimQDFLALRKVMKD----TgalnminpasalfrstmrryihTPPSFAPIIQS
.|| | .   .. .. .|.. |.| .|    ..| .. . .|.. ..|  ..  .| .....    .                      .. |   ....
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvp..espkslldlirkveksk......................eaksgpvvVhC

ARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVL
  |..|.| ||..|.|..... ...   .| ... . .. |...|  .    |.|.|.|
saGvgRtgtfvaldilleqleaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
0037934 (Phosphotyrosine protein) phosphatases II 28-284 1.1e-31 105.7 In-house 7-241 (243) alignment 
Range on Protein: 28-284
Range on HMM: 7-241/243.0
RLEAVNRNRVVKIVPQHRYNVRLtpsmlNRDGYINASLMEFSDvgqKYILTGIPSEDKVFA----FWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPdkG
..| ...||.  |.|  .  |.|     . ..||||.|..  .   ..|.|. | .. |.     ||.|. |... .|. . . || . | ...|.|  |
lpenlsknrysdilpydhsrvkl.....egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..g

DVwSYGHLQVERKSYAIHqGNFHTRNFILRK---GNETHRVLHFTVFGWTETTTPI-MQDFLalrkvmkdtgalnminpasaLFRSTMRRYIHT------
.|  ||...|. .|.  . .... |.. |.    ...|. | |.  ..| . ..|  ..|.|                     | . .| .|.       
ev.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedll....................dfldevrefieellslla

-PPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgkktNlYSVEDLIVKCKHMRIH-CVPVALHHSFIYEAVLDY
 ...   ..    | .|.|......|.....     . ...|. . . . .| . .|.   .  |.|||.| .
ldsggpvlVHCsaGvgRtGtliaaylmllll.....g.vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_PTPRD_pd Subfamily PTPRD 32-288 8.4e-30 98.9 In-house 49-284 (564) alignment 
Range on Protein: 32-288
Range on HMM: 49-284/564.0
VNRNRVVKIVPQHRYNVRLTPSML-NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGdVWSYGH
 ..||. .||.  .  |.|..    .   ||||| ..  .  ..|| |  | .. .  ||.|| ||.| ||.     .|.. . ..||.|.||   .||.
kaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekg.tetyge

LQVERKSyAIHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGAlnminpasalfrstmrryihtpPSFAP-IIQSARG
|.|. ..   .  ... |.|.|.|   .|.. | .|    | ..  |   ...|.|.. ....                        |   | ...   |
ltVtlee.eeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne......................pdagPivVhCSaG

SSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
  | |.|.||| ... |  |. ..  .   . . .. | . |      .||.||.|..|   
VGRTGtfividamleri..keektvDiyqyvkalrkqRnamVqteeQYiFiheailealacg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 22-286 7e-29 96.0 In-house 47-291 (298) alignment 
Range on Protein: 22-286
Range on HMM: 47-291/298.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
. .|. . |  ..||  .|..     |.|.    .    ||||| ..  .  . .|.|  | .  |  ||.|| |. . ||. . . .| .  .| ||.|
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP

DKGDVwSYGHLQVERKSYAiHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIMQdflalrkvmkdTGALNminpasalFRSTMRRYIHTPPSFA
|.|    ||...|. .|   ..... .|.... |   .....| .. .. |.. ..| ..           |  |.        ... .|.. .     .
degke.tygeitvsllske.efadlivrklkvskkkeekerevrqlhftsWpdkgvpena...........tsvld........llrkvrasqqqagnkp

PIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
 |.| . |  |.|.|..|| ..  .  || .   | . .   .. |.. |    . .|||||||..| 
vivqCsaGvgRsGtfiaidsvlerv..kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 30-283 3.5e-27 90.2 In-house 46-277 (288) alignment 
Range on Protein: 30-283
Range on HMM: 46-277/288.0
EAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWSY
.  ..||   |.|    .|.|.     .   ||||| .. ..  .||| |  |  | |  ||..| |... ||. ... ||.  .. ..|.||...   |
vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpkny

GHLQVERKSYAiHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNminpasalfrstmrryihtppSFAPIIQSARGS
|...|. ..   ....| .|...| | ..  .. ..   .|...  |   ...|.|.. .| .   .                     .   |.. . | 
Gsvtvtlvesk.eledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.....................tgpiivhCsaGv

SRAGAFVVIDLLIRMIDGkkTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
 |.| |...| || ...   ..   | . . | .. |   | .  .. ||||..|.
GrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN6_pd Subfamily PTPN6 15-289 4.9e-27 89.7 In-house 38-301 (306) alignment 
Range on Protein: 15-289
Range on HMM: 38-301/306.0
DDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLME--FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKL
.... ||| . .|. |  ..||   |.|     | |. . .  . ||||. ..  . .  ..|| |    |. |  ||.||... |  |.    .||   
eeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgk

EHYDKYFPDKGDVWSYGHLQVERKSYaIHQGNFHTRNFILR---KGNETHRVLHFTVFGWTETTTPIMQDFL--ALRKVMKDTGALNminpasalfrstm
|.  .|.||. .  .||...|.  |   .. ..  |.. .    |..|...| ..    | .  .|  .. .   |..| . .  |.             
ekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele.............

rryiHTpPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNL-YSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
    ..  . . ..  . |  | |.|.|||.|...|  |...  . ...|. . .. |   | ..  . |.|.|.  |. ...
....ea.eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPRB_pd Subfamily PTPRB 29-288 7.9e-27 89.0 In-house 49-288 (293) alignment 
Range on Protein: 29-288
Range on HMM: 49-288/293.0
LEAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWS
 .  ..||  .|.|     |.|..    . . ||||. ..     ...| |  |  . |  ||.||.|..| .|. . . ||.  .. ..|.|.. .   
avnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvl

YGHLQVERKSyAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPimqdflalrkvmkdTGALNMINpasalFRSTMRRYIHTPPSFAPII-QSARG
||...|. ..   .. .. .|.. ..|..|...| ..    |..   |                . ....     |  |.|..|..  | .||.   . |
yGdikvtlva.eeeledwvirelkiekekeerkvrqyhftsWpdhgvP..............ektktlld.....fvrtvreaiektaskrPivvhCsaG

SSRAGAFVVIDLLIRMIDGkkTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
  |.|.|. .| |.. |.   ...  .  .... .. | . |    .. ||...|||.| ..
vGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 25-294 1.5e-26 88.1 In-house 3-247 (250) alignment 
Range on Protein: 25-294
Range on HMM: 3-247/250.0
VTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdNVEEKLEHYDKYFP-DK
|. ...  ..||  .|..     | | ..  ..   ||||| ..  |  . .| |  | .. .  ||.||||. | ||. .. |..|. . | .|.| .|
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLt.nLkesektyhqywPvek

GDvwSYGHLQVERKSYAIhQGNFHTRNFILRKGNETHR--VLHFTVFGWTETTTPIMQdflalrkvmkdTGALNMINPASALfrstmRRYIHTPPSfapI
 .   ||...|. .|  .  ... .|...| | .....  | ..  . | . . | .            | .|....   |      ...... |    |
ae..kyGdvtvsllskee.fadytkrklklskakkaderivrqlhfvvWPdkgvPeva...........tavLellkkvqas.....qqqagnaPv...i

IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRrnprFQD
.| . | .|.|||..|| ..  .  || .   | ..| . .. |.| |     ..|.||..| .|      ..|
vqCsaGvgrsGafiaidavlerl..kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds....ved
subfamily_Ptp69D_pd Subfamily Ptp69D 13-286 5.5e-26 86.4 In-house 30-287 (307) alignment 
Range on Protein: 13-286
Range on HMM: 30-287/307.0
KLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEK
||  ..  .| .|... |   .||  .|..  .. |.|..  . .   ||||| ..  .  .|.|    | |  .. ||.|. || . .|.  ..  | .
kLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnltekn

LEHYDKYFPDKgDVWSYGHLQVERKSYAIHQgNFHTRNFILRKGN-------ETHRVLHFTVFGWTETTTPIMQDflALRKVMKDTGALNMINpasalfr
 .. .||.|.  |   ||.. |.  |   |. ..  |.. . | .       ....|. .   || ... | .    .| |...    |.  |       
rkkcakYWpie.devqygdilvklvseekhs.dyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar..gllklieqvrelykln.......

stmrryihtppsFAPI-IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
             .|| .    |..|.| || .|.|.  .  |. .  .. . . . .. |   |     ..|.| |.|||  
............rsPivvhCsaGvgrsgifvaldsllqql..kaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 8-290 7.1e-26 85.8 In-house 22-282 (315) alignment 
Range on Protein: 8-290
Range on HMM: 22-282/315.0
SNIVHKLDDNqPLLSERVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAD
|. .| | |  .   .||.   .  ..||   |.| ..  |.|        . ||||| ..  |  . || .  | .  |  ||.|||...  ||.  ..
seefhdlpdP.diyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

NVEEKLEHYDKYFPD-KGDVWSYGHLQVERKSYAIhQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDflALRKVMKDTGAlnminpasalfrs
  |.   .  .|.|| |.|   .| ..||  |    ...  .|....||..|...|  |   .| .  ..  .   .| |..|.  |             
kqegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts..sllklikevka.............

tmrRyiHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
      . .  |. ..  . |  |.| .. ||  .  |  |.|.   | ... . .  |.. |    ...|||.|||..|| || 
...d..ngkkefsllvhcsaGvGrtGvvisidevvaqi..krtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt
subfamily_PTPN14_pd Subfamily PTPN14 28-286 1.6e-25 84.7 In-house 45-297 (300) alignment 
Range on Protein: 28-286
Range on HMM: 45-297/300.0
R-LEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQ--KYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK--
.  | ...||. ...| .   |.|.|.  |..|||||| .. |  |.  .|| .  | |  |  ||||| ||    |.. ... |.  |.  ||||..  
klpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkles

-GDVWSYGHLQVERKsYAIHQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPI-MQDFLALrkvmkdtgaLNMINPASALFRSTMRRYIHTPPsfa
  .   .|. .|  | .  . . . |. . |.    .|   |.|.    |..   |  ...||           |....     . |..    . ||   
kkktvefgkfkvttk.fsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsy.........LeevqsvrrktnseveskeskPP...

PIIQSARGSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
 ..  . |  |.|  .. ||||  ..  ..    ..  . . .. | . |.    . |.|.... || 
vlvhCsaGvGrtGvlilsdlliatlehnee..idikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 26-288 1.9e-25 84.4 In-house 15-267 (270) alignment 
Range on Protein: 26-288
Range on HMM: 15-267/270.0
TARLEAVNRNRVVKIVPQHRYNVRLTPSMLN-RDGYINASLME-FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKG
 .     . ||   |.|. .  ||| .   . .  ||||  .. |..  .||| .  | .  ...||.|..|.....|.  .. .|.  .. ..|.| . 
peaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

DV---WSYGHLQVERKSYAIHQGNFHTRNFILrKGNETHRVLHFTVFGWTETTTPIMQDflalrKVMKDTGALNMINPASAlFRSTMRRyiHTpPsfaPI
.     ..|...|   | . ..|   ||  .  .  |..|..||    | . . | ..|     .... .  |.|..   . ... ...   . |    .
kekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreed.....sslstdqllkmlravrr.sekeldk..ae.P...ll

IQSARGSSRAGAFVVIDLLIRMIDgkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
.  . |  |.| ....|  .|...  .|.   |  .| . .. |. .|    .  |.|.||. |  ||
vHcsaGvgRtGtlialDiavrlLe..etkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPRA_pd Subfamily PTPRA 26-287 6e-25 82.8 In-house 53-297 (330) alignment 
Range on Protein: 26-287
Range on HMM: 53-297/330.0
TARLEAVNRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGd
... |  ..||||.|.| .   | |..    .   ||||| ..     .|.| .  | |. |  ||.|. ||.| ||. ...  | | |   .|.||.| 
askeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG.

VWSYGHLQVERKSYAIHQgNFHTRNFILR-KGNET-----HRVLHFTVFGWTETTTPImqdflalrkvmKDTGALNMINPASALFRSTMrryihtPpsfA
...||...|| .   . . ..  |.|... ....|       |  |   .| .   |.           .  | |....   .| . .           .
lvtyGnirvevedetvlv.dytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPf...........epiGmlkllkkvkklnqqsa......g...p

PIIQSARGSSRAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
 ..  . |  |.|.|.|.| .. ..  ..  .  | . . . .  | . |     . |||...|.| | 
ivvhcsaGvGrtGtfivldavlervkaer..kvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_PTPRG_pd Subfamily PTPRG 30-290 1.5e-24 81.2 In-house 46-292 (563) alignment 
Range on Protein: 30-290
Range on HMM: 46-292/563.0
EAVNRNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkGDVWS
|  ..|| ..||.  |  |.|.|     ..  ||||. ..    ....| |  |..| .  ||.|. ||.. .|.  .. ||.. .. | |.|   ..  
enkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.deset

YGHLQVERKSYAI----HQGNFHTRNFILRKGNE---THRVLHFTVFGWTETTTPIMQDFlALRKVMKDtgalnminpasalfrstmrrYIHTPPSFAPI
||.|||  ..  .     . ..  .|..|.|...    ..| ..    | ....|  . .  |  | |.                       ..    ||
ygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslp.vLifvkks....................saankaeaGPi

I-QSARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
.     | .|.| ..|.| |.. |  .  |   | ... . . .| . |       |...|.|. .. .. 
vvHcsaGvgrtGtyivldtllkqiqqe..navnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_PTPN3_pd Subfamily PTPN3 24-283 1.6e-24 81.3 In-house 34-273 (280) alignment 
Range on Protein: 24-283
Range on HMM: 34-273/280.0
RVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLnrdGYINASLMEFSDVG----QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYF
 .. . | ...||   |.|     |.|. |      ||||. ...   .    ..|| |  | .. .  ||||| ||.| .|. ....||.      .|.
saarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyW

PDKGDVWSYGHLQVERKSYaIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGalnminpasalfrstmrryihtPPS
|...| ..||...|. ..   .. .. .|...|.. .  | ...|..    |.. . |   .||| . . ....                         .
Petedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr......................sgk

FA-PIIQSARGSSRAGAFVVIDLLIRMIDGKKtNLYSVeDLIVKCKHMRIHCVPVALHHSFIYEAVLD
    ..  . |  |.| ...... . .|. .. ..| . |.. . .  |   |. |  . |. ||.| 
eePvvvhCsaGigrtGvlilletalalieaae.pvypl.divrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN23_pd Subfamily PTPN23 30-287 1.7e-23 77.9 In-house 42-282 (288) alignment 
Range on Protein: 30-287
Range on HMM: 42-282/288.0
EAVNRNRVVKIVPQHRYNVRLTpsmLNRDGYINASLME-FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWS
  ...||   |.|  .  | |     ..| ||||| ..  | .  ..| |  | .  .  ||.|| ||.|..|.   .. | . .. |.|.| |||.  .
lyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YGHLQVERKSYAiHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNMINPASalfrstmrryihtppsfaPII-QS
.|.|.|  ||   . ...  |...|.  . .... | |  .. |.|   |   ...|.. ......   .  .                     |.. . 
fgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt..................PlvvhC

ARGSSRAGAFVVIDLLIRMIdGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  |. |.|.| ..   .| .  |.  |  . ... . .. | . |    .  | ||||| .  |
saGvgRtgvfalvyaavrel.ekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_PTPRK_pd Subfamily PTPRK 28-285 3.1e-23 77.1 In-house 40-277 (314) alignment 
Range on Protein: 28-285
Range on HMM: 40-277/314.0
RLEAVNRNRVVKIVPQHRYNVRLTPSMLN-RDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVw
. |  ..||. .|..  |  |.|..   .    ||||.|..     ...| |  | .. |  ||..|..... .|.  .. ||.   .  ||.|....| 
kdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.

sYGHLQVERKSYAIHQgNFHTRNFILRK----GNETHRVLHFTVFGWTETTTPIMQDflALRKVMKDtgaLNMINPAsalfrstmrryihtpPSFAPIIQ
 ||...||  .  ... .. .| | ..|     .|.. | .|   ||..  .|  .   .| |...    ... ..                     .. 
.ygdikvelvetella.elvvrifrveklargqeeirevrqfqflgWpdhdvPvsat..gllklvrr...vkksqee...............eaGrivvh

SARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
   |. |.|.|..|| .. ||  .. ..  |   . . .  ..  | .   . |||...|.  
CsaGaGrtGtfiaidivldmi..eregvvdvfnavktlrsrkvnmveteeqykfiydvileac
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 31-289 3.9e-23 77.0 In-house 44-284 (318) alignment 
Range on Protein: 31-289
Range on HMM: 44-284/318.0
AVN--RNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVwS
 ||  .|| . |..  .  |.|..   .    ||||. ..     ..|| .  |  . .  ||.|| || | .|. ... .|.  .  ..|.|.||   |
pvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr.s

YGHLQVERKSyAIHQGNFHTRNFILRKGN--ETHRVLHFTVFGWTETTTPIMQdflalrkvmkdTGALNMINPASALFRSTMRRYIhtppsfapIIQSAR
||.|.|| |.  .. ...  |.| ... .  |.  |  . .  |... .|              .. |...  .|.  ... .. |        ..  . 
ygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg...........aslldlvrqvskaqqksgagpi........vvhCsa

GSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
|  |.| |...| |.. |  |. .|  | . . . .. |   | .   . |||...|..|   .
GvGrtGvfiavdilleri..kaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd
subfamily_PTPN1_pd Subfamily PTPN1 9-283 5.2e-22 72.9 In-house 10-269 (290) alignment 
Range on Protein: 9-283
Range on HMM: 10-269/290.0
NIVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLnrdGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNV
.|.......   .. |.. . |  |.||   . | .   ..|  .      ||||||.|. .. ..||||  |  . |  ||||| ||.| ... .   |
eiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvv

EEKLEHYDKYFPDKGD--VWSYG--HLQVERKSYAIHQgNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGALNminpasa
|..     .|.| . .     .   .|.|.  |  ... ..  | . | .   .||. .|||    |.. . |   . || .   ....|.|.       
ekeqikcaqywPqgeeekellledtklkvkliseerks.yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.......

lfRStmrryiHTPpsfaPIIQSARGSSRAGAFVVIDLLIRMIDGKK-TNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
  .       . |    ..|  . |  |.|.|...| ..  |. |. ..   ... ... ...|.  .  |    | | |.|.
..sd......vGp....avihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 31-286 7.9e-22 72.6 In-house 28-269 (274) alignment 
Range on Protein: 31-286
Range on HMM: 28-269/274.0
AVNRNRVVKIVPQHRYNVRLTPSMLNRD--GYINASLMEFSD-VGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV--
. ..||  .|.| ..  | |...  . .   ||||  .   | . . |. |  |    |. ||.|. ..... |.  ..  |.. .   .||||. |.  
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

-WSYGHLQVERKSyAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPimQDFLALRKVMKDTgalnminpasalfrsT------------Mrryih
   ||..... .. .... ... |...|.. .....| |.    | .. .|  .|  .| ......                            .     
serygdveikvek.iverndysvrklvlkylerersvkhywytdWPdhksP..ddantlldlvlev...............eesreeenaklapv.....

tppsfapIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
       ..  . |  |.|.|. |.. .| .  ....   |  .... .  |   |  .  . .|..|.  || 
.......vvhCsaGiGrtGcfiaisiavrql..reeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 32-290 3e-21 70.1 In-house 44-281 (515) alignment 
Range on Protein: 32-290
Range on HMM: 44-281/515.0
VNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGDVWSYG
 ..||   |.| ..  |.|          |.||| ..  |  . || .  | .  |  ||..||...  ||.  ..  |.   .  ||.||  ||   .|
fkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfG

HLQVERKSYAIHQGnFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMqdFLALRKVMKDTgalnminpasalfRSTMRRYIhtppsFAPIIQSARGSSR
...||  |     |    |.. . ||.... |  |   .| .  .|      .| |..|.              ..   .|      .. ||  . |  |
sikvelvsleactg.gikrkltvlkgddsrtvtqfhfteWPdkGvpkh..tssllklikev.............kadhgqyt.....hpliihcsaGvGr

AGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
.| .. ||  .  .  |.|.   | ... . .  | . |    ...|||.|||..|| || 
tGvvisidsvvaha..kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrnt
subfamily_CG7180_pd Subfamily CG7180 24-287 4.7e-21 69.7 In-house 35-292 (296) alignment 
Range on Protein: 24-287
Range on HMM: 35-292/296.0
RVTARLEAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLeHYDKYFPDK
.   |.|  ..|| ||.||     | |.     ... ||||. ..     ..|| |  | .. | .||..| .. . ...  ... . .   | .|.| |
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GdVWSYGHLQVERKSYAIHqGNFHTRNFILRKGnethrvlhftVFGWTETTTPIMQDFLALRKVMKDTGALNMINPAS--AL--FRSTMRRYIHTP---P
.    ||.. ||  ..     |...|.| | |           .   ||.....  .   ....   .  |.   | |  ||  .|  .| ...     |
s.keqygeifveiveekqy.anlkirtfkltkk..........ivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedp

SFAPI-IQSARGSSRAGAFVVIDLLIRMIDgkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  .|. . |  |.||.|... ||  . ...  |..   | . . . .. | . |    .  .||. .|...| 
eegPvvvvssdGasRsGvylaidanlelve..keeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlc
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 24-284 4.8e-21 70.0 In-house 42-278 (315) alignment 
Range on Protein: 24-284
Range on HMM: 42-278/315.0
RVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK
.|. . | ...|| ..|..  .  |.|      .   |.||....  .  ..|| .  |    |  ||..| |.   .|. ... ||.. .. .||.|||
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

gdVWSYGHLQVERKSYAiHQGNFHTRNFILRKGNETHRVLHFTVFGWTETttpimqdflalrKVMKDTGALnmINpasaLFRSTMRryIHTPPSFAPIIQ
     ||.. | |||   .. ..  | .    |.. . |. . .  | ..            .| | | .|  .|    |.|  ..   ||    | .. 
..kviyGkitvtrksee.vnteytvrtlsvvfgdnirevvqlhytswpdm............gvpkytipl..mn....lirtvkq..hhtnsvgaivvh

SARGSSRAGAFVVIDLLIRMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDY
   |  |.|.|. .| ..  .. .  |.  | ..| . ...||. | ||  . |||.|.|. 
csaGvGrtGtfitldavldqaeae..naidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 25-299 9.7e-21 69.1 In-house 42-299 (319) alignment 
Range on Protein: 25-299
Range on HMM: 42-299/319.0
VTARLEAVNRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPdKG
 . . |  ..||   |..  |  | |..    .   ||||| ..  .  .|.| |  | |. .  ||.|| |..| ...  .. ||.   .. ||.| . 
saskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywp.ee

DVWSYGHLQVERKSYAiHQGNFHTRNFILRKGN---ETHRVLHFTVFGWTETTTPimqdflalrkvMKDTGALNMINPasaLfRSTMRRYIHTPPsfapI
....||.| |. ..   .. ..  |.. |.| .   || .| ||.   |..   |            | |. |....    . | ....  . |     .
nfeeyGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvP...........ekatslldllkr...i.rksrektqsgPi....v

IQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN--PRFQDFKEPL
.  . |. | |.|.|.|  .  .  |. ..  |   . . .  |   |     ..|||||.|...   .   . ||... |
vhCsaGvGRtGtfivldamlerv..keegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 31-292 2.2e-20 68.0 In-house 51-291 (297) alignment 
Range on Protein: 31-292
Range on HMM: 51-291/297.0
AVNRNRVVKIVPQHRYNVRLTPSMLN-RDGYINASLMEFSDVgqKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNvEEKLEHYDKYFPDKGDVWsYG
  ...|   |.| ..  |.|     .    |.||| ..      ..| |  | .. |  ||.|||...  ||.  .|. .|. ..  .|..||| .  .|
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlndd.nerdkkcaryWsdkgvtt.fG

HLQVERKSYAIHQGnFHTRNFILRKGN--ETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDtgalnminpasalfrstMRRYIHTPPSFAPIIQSARGS
.. |. .| .  .| |  |.. ..||.   .. |  .    | . . .  ..  .| |....                 .|    .  .   ..    | 
dvsvvllsvsereG.fikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklise.................vrkdfsqnaegPllvhclaGv

SRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNPRF
 |.| .. ||  .  .  |...   . .|. | .. | . |    ...|.|.|||..||  . | 
Grtgvlltidsvvaea..krekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtri
subfamily_PTPN12_pd Subfamily PTPN12 22-286 2.3e-20 67.7 In-house 31-278 (290) alignment 
Range on Protein: 22-286
Range on HMM: 31-278/290.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
|  .. . | |..||   |.|     | |.    .  ..||||.... ..  ..|| .  |  . .  ||.|. |..   ..    .|| .  . ..|.|
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DKGDVWS-YGHLQVERKSYAIHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTPIMQDFLalrkvmkdtgaLNMINpasaLFRSTMRryihtPPSFAP
..|.    .|...|. ..    . .|  | . ... .|...|  |    | .  .|  .. |           |..|.    |.|.. .       .   
eegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksl...........lelie....lvrelqe.....sedaPl

IIQSARGSSRAGAFVVIDLLIRMIDGKKT-NLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
..  . |  |.|. ..||.  ...  .|. . ..| ||... .. |   |     ....|.||.... 
vvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN9_pd Subfamily PTPN9 32-287 2.7e-20 67.6 In-house 43-292 (297) alignment 
Range on Protein: 32-287
Range on HMM: 43-292/297.0
VNRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP-DKGDVWSYG
...||   ..   .  | |.     .   ||||. ..     . .| |  | .  |  ||.|| ||.  .|.  .  ||..     .|.| ..... ..|
leknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg

HLQVERKSYAiHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIM-QDFLALRKVMKDTGALnminpASALFRSTMRRYIHTPPSfapIIQSARG
.|.|.. .   .. ....| . ..  | .|. .| || . .| .  .|   ...| ........ ||     |.  . .. .  .. ||    ..  . |
dlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal.....avkelgdewkghpsgPPi...vvhcsaG

SSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  |.|.|. .|. .  .  ....   | . . . .  | . . .   . | | |||.| |.
iGrtGtfitldiclsrl..eevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 28-190 8.3e-19 62.8 In-house 38-202 (281) alignment 
Range on Protein: 28-190
Range on HMM: 38-202/281.0
RLEAVNRNRVVKIVPQHRYNVRLTPSMLNRD-GYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVW
. | |..|| . ||      |..||.  | .  ||||. ..  .  ..|| |  |  . . ||||||.||.  .|.  . ..|.   .  .|.||.    
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnsel

SYGHLQVERKSYAIHQgNFHTRNFIL-RKGNETHRVLHFTVFGWTETTTPI-MQDFLALRKVMKDT
.||...|. .. . .. .. .|.| | |...|| .| ...   | ..  |   ...|  || .. .
kygdvtvkstaeeeka.tyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 28-175 1e-18 62.5 In-house 43-194 (305) alignment 
Range on Protein: 28-175
Range on HMM: 43-194/305.0
RLEAVNRNRVVKIVPQHRYNVRLTPSMLNR-DGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGD-V
. . ...||...|....   ..||..  .    ||||| ..  .  .|||..  | .. |  ||....| .  ||..... ||.. .   .|.|..   .
keankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktek

WSYGHLQVERKSYAIHQgNFHTRNFILRK---GNETHRVLHFTVFGWTETTTP
  .|...|| || .  . .. .|.. . .    .|.. ||.. .  | .   |
kefgefsvelksektas.dyieRklkisiededkesrtvlqyqltdWPdhGvp
subfamily_PTPRN_pd Subfamily PTPRN 23-183 1.7e-18 61.3 In-house 48-212 (297) alignment 
Range on Protein: 23-183
Range on HMM: 48-212/297.0
ERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLMEFSDVG-QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
. |. . ..|..||. ...|     |.|.  .  ... ||||| .  .|     || |  |  ..| .||||| || .  |....   || ... ..|.|
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp

DKGDVwSYGHLQVERKSYAIHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIMQ-DFLAL
|.|    |.  .|.  |  |   ..  | | |.  . .||  |  |  . |.|...|     .| .
deGse.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef
subfamily_PTPN13_pd Subfamily PTPN13 12-285 8e-17 56.4 In-house 18-269 (273) alignment 
Range on Protein: 12-285
Range on HMM: 18-269/273.0
HKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPSmlnrDGYINASLMEFS--DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVE
..| . .||.. .|. . |  ..||  ...|  .  |.|  .     |||||||..    .   .||..  |  . |  ||||| ||..  |.  . ..|
kelrelkpldtcevgkkkenkdknryrnvlPydetrvklgde....ggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtleke

EKLEHYDKYFPDKG--DVWSYGHLQVERKSYAiHQGNFHTRNFILRK--GNETHRVLHFTVFGWTETTTPimqdflalrkvmkdTGALNMINpasalFRS
..    ..|.|..    .  .. |.||   .  .. .|  |.. ...   .|...| |.    | .  .|              . |.....     | .
kgkvkchrywPesknkklkvsnrlevellkvq.kldgfvvralavkdsesgesrevahlnfvkwPdhgvP..............ssaaellq.....fva

TMRRyIHTppSFAPII-QSARGSSRAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
 .|| ..|  . .||.   . |  |.|....|| .. .|. .|   . |.... | .. |   |     . |.|.|.|. |
evrr.lqt..dagPivvhcsaGiGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 22-173 1.1e-16 55.6 In-house 37-192 (290) alignment 
Range on Protein: 22-173
Range on HMM: 37-192/290.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRD---GYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKY
.  |    .  ..||  .||..  . . | |   ..|    ||||. ..     ..||.|  | .. .  ||... ..... |.   . .||. ..  .|
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

FPDKgDVWSYGHLQVERKSYAIHQgNFHTRNFILRKGNE---THRVLHFTVFGWTETT
.||. |. .||. ...  .  ... .. .|.. ... |.   .. | .. .  | .| 
Wpds.dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstg
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 24-180 1.7e-16 55.0 In-house 26-184 (283) alignment 
Range on Protein: 24-180
Range on HMM: 26-184/283.0
RVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLnrdGYINASLME---FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFP
 ...  |  . ||  .|||. .. |.| .       ||||. .      . ..||| .  | .. |  ||.|| ...  .|. ..   |.. ..  .|.|
diasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP

DKGDVwSYGHLQVERKSYAIHQgNFHTRNFILRKG---NETHRVLHFTVFGWTETT-TPIMQDF
 .| .  || . |  .    ..  |  ....||.    ..|  . |. | .|.|    .|.  .
krGse.dyGeftvtlrkettsn.sfiikelllrvnssakstlllahyqvidWleygeqaiinsl
0036282 (Phosphotyrosine protein) phosphatases II 58-279 2.9e-16 55.1 In-house 2-164 (174) alignment 
Range on Protein: 58-279
Range on HMM: 2-164/174.0
DGYINASLMEFSDVGQKYILTGIPSEdkvfaFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkgdvwsyghlqverksyaihqgnfhtrnfilRKGNE
. ||||| . .| .  ..|... | .     ||.|. |... |.... . .| .|.    |.|.                               ..  .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

THRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGalnminpasalfrstmrryiHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDgkkTNLYSVEDLI
.. ....  ..|   ..| .. .| . | ...                        .|.   ..    | .|.|..|...|..|..    ..|  . ||.
erlgiqylylpwpDhgvpdlsillefvkfveeal....................sedpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlv

VKCKHMRIHCVPVALHHSFIYE
 ... .| ..|.   .  |.|.
relRlqrpgmvqtpsQyrflyy
subfamily_CG42327_pd Subfamily CG42327 5-177 3e-16 54.0 In-house 2-179 (319) alignment 
Range on Protein: 5-177
Range on HMM: 2-179/319.0
SIRSNIVHKLDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTP-SMLNRDGYINASLME-FSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTII
. |.... ...|   |...       . ...||...||    .| |   .  ..| |..|| .  . |    || . .. ||   .||..| ||.| .|.
erredvaeefrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrviv

QFADNVEEKLEHYDKYFPDKG---DVWSYGHLQVERKSYAIHQGnFHTRNFILRK-GNETHRVLHFTVFGWTETTTPIM
| .|  |  ..   .|.| |    .  .||...|  |  ....  . .  ..|..  .|  | |    . | |.  |  
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdr.yaistlllkrvdkeesrelthywykwleaevPae
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 12-290 5.1e-16 53.1 In-house 27-241 (392) alignment 
Range on Protein: 12-290
Range on HMM: 27-241/392.0
HKLDDnQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEE
| | .  ..  ..|. .   ...||  .|.| ..  |.|      . . |.||| ..  |  . || .  |    .  ||.||....  ||.  ..  | 
hdlpg.pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkeg

KlehydkyfpdkgdvwsyghlqverksyaihqgnfhtrnfilrKGNETHRVLHFTVFGWTETTTPIMQDflALRKVMKDtgalnminpASALFRStmrrY
                                           ||.... |  | .  | .   |      .| |..|.          .| | .    |
d..........................................kgddartvaqfhftewPdkdvpkhts..sllkfike.........vkadfGq....y

IHtpPsfaPIIQSARGSSRAGAFVVIDLLIrmIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
 |  |    ||. . |  |.|  . || ..     ||| .  | ..... .. | . | .  ...||| |||. || || 
th..p...liihcsagvgrtgvvisidsvv..ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrnt
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 33-285 5.2e-16 54.0 In-house 27-256 (284) alignment 
Range on Protein: 33-285
Range on HMM: 27-256/284.0
NRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdnveekLEHYDKYFPDKGDVwSYGHL
..||...|..  .  |.| . .  .   ||||| ..     .||| |  | .. .  ||.|. |... ||. ..       ..  .|.| |...  ... 
dknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerf

QVERKSYAiHQGNFHTRNFILRK-GNET--HRVLHFTVFGWTETTTPIMQdflalRKVmkdtgaLNMINPASALFRStMRryiHTPPSfapIIQSARGSS
.|. .|      ..  |.. | . |.|.   ..  |   || .   | .       ..      . ...  . | .  ..   |  .    ..  . |. 
kvkvdsve.eseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp.....sdl......mrlvkkvrhltsk.en...hrani...vvhcsagvg

RAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD-YL
|.|...|.| |. ... .|     | ... . .  | . |     . ||| |.|. .|
rtgvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 33-285 7.6e-16 53.3 In-house 63-292 (319) alignment 
Range on Protein: 33-285
Range on HMM: 63-292/319.0
NRNRVVKIVPQHRYNVRLTPSM-LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdnveekLEHYDKYFPDKGDVwSYGHL
..||...|..  .  |.| .    .   ||||| ..     .||| .  | .. .  ||.|. |... ||. ..       ..  .|.| |...  ... 
dknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivi.keerf

QVERKSYAiHQGNFHTRNFILRK-GNET--HRVLHFTVFGWTETTTPIMQdflalRKVmkdtgaLNMINPASALFRStMRryiHTPPSfapIIQSARGSS
.|. .|      ..  |.. | . |.|.   ..  |   || .   |         ..      . ...  . | .  ..   |  .    ..  . |. 
kvkvdsve.etaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp.....sdl......mrlvkkvrhltsk.en...hrani...vvhcsaGvG

RAGAFVVIDLLIRMIDGKKtnLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD-YL
|.|...|.| |. ... .|     | ...   .  | . |     . ||| |.|. .|
rtGvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
0041856 (Phosphotyrosine protein) phosphatases II 33-290 2.1e-15 52.3 In-house 3-176 (182) alignment 
Range on Protein: 33-290
Range on HMM: 3-176/182.0
NRNRVVKIVPQHRYNvrltpsmlnRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAdnveeklehYDKYFPdkgdvwsyghlq
..||...|.| ..              ||||.|. .|  ....|.|  |  . | .|..|. |..  ||.  .          . |.|            
dknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

verksyaihqgnfhtrnfilrkGNETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDtgalnminpasalfrstmrryihtpPSFAPIIQSARGSSRAGA
                       .... ....  ..|   ..| ....|.. . ...                         .. . ..    | .|.|.
......................ellerlgiqylylpwpDhgvpdldelldfieevle.........................eggpvlVHCsaGvgRtgt

FVVIDLLIRMidgkktNlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRNP
.|...|....      . .|.|. .   . .| ..|    .. |.. |.|..||... 
lvaaylmkkl......g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 26-173 2.7e-14 47.8 In-house 40-187 (287) alignment 
Range on Protein: 26-173
Range on HMM: 40-187/287.0
TARLEAV--NRNRVVKIVPQHRYNVRLTpsmLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKG
|  .     ..||. .|...  | | |     ... ||||. ..     ...|..  |  . .  ||... ... ..|.  ... |.. |   .|.|.. 
thniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeek

DvWSYGHLQVERKSYAiHQGNFHTRNFILRKGN---ETHRVLHFTVFGWTETT
   ..|. ..|  .   .. ..  |.. ... |   ....|  . .  | .| 
s.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstg
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 26-177 2.9e-14 47.5 In-house 33-186 (287) alignment 
Range on Protein: 26-177
Range on HMM: 33-186/287.0
TARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV
.  | ||..||  ...|     | |.        ||||  .      ...| .  |    |  ||..|||.|| ..|  . .|||   .  ||.|..   
aeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevP

WSYGHLQVERKSYAIHQGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIM
   |   |   .| | . .. .| . |   ...|.. |  . .. | . . .  
mrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 34-265 1.5e-13 45.5 In-house 6-219 (237) alignment 
Range on Protein: 34-265
Range on HMM: 6-219/237.0
RNRVVKIVPQHRYNVRLTPSMLNRDgYINASLM-EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVWSYGHLQ
.||  .||      | |  .  . | ||||. . .|    .||| .  | |     ||||| ...   |. ..  .| . ..  ||.|.  .  .|| | 
knrygnivaydhsrvvlkgagsgsd.yinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvlt

VERKSYAiHQGNFHTRNFILRKGNETHRVLHftVFGWTETTTPImqdflalRKVMKDTGALNMinpasaLFRSTMRRYIHTPPSFAPIIQSARGSSRAGA
|  |    .  ..  | ..| |  . . |    .. .  |. |        | | . | ||        . .  . |  | . |   ||  . |  |.| 
vslkkke.efsdytvrslllskrltlkevrl..ihqyqftswpd.......rgvpqqtaallr......frkniinrsphvsesgpwiihcsagvgrtgi

FVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRI
|.||| ..|    ||     . . .   .  | 
flvidamlrqakekkv..vdiynyvysieedrp
0051429 (Phosphotyrosine protein) phosphatases II 55-287 1.6e-13 46.4 In-house 1-227 (272) alignment 
Range on Protein: 55-287
Range on HMM: 1-227/272.0
LNRDGYINASLMEFSdvGQ-----KYILTGIPSEDKVFAFWQMvLEQRSPTIIQFADNVEEKLEHYDKYFP-----------DKGDVWSYGHLQVERKSY
|. .|||||. .     |.     .....| |..  .  ||..  |..  ||. . . .| . . .|.| |           |     .||.| |   |.
lplsgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllse

AiHQGNFHTRNFILR---KGNETHRVLHFTVFGWTETTTPImQDFLALRKVMKDtgalnminpasalfrstmrryihtppSFAPIIQSARGSSRAGAFVV
  .. ... |...|.   . .|...|.|..  .|    .|  . .|.| ... |                          . . ..  . | .| | .|.
e.llldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld..........................ggpvlvHCsaGkdRTGtvva

IDLLIRMIDGK-------KTNLYsVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
..||.. ..         .|||| .|. . . . .| . |.   .  |.|||.|..| .
llllllgvsletivddYlltnly.leeaveelraqrpgavqteeqylflyeallellrs
0043147 (Phosphotyrosine protein) phosphatases II 57-279 3.5e-13 45.1 In-house 4-155 (172) alignment 
Range on Protein: 57-279
Range on HMM: 4-155/172.0
RDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNveeklehydkyfpdkgdvwsyghlqverksyaihqgnfhtrnfILRKGN
.. |||||..... . ...| |  |    .  ||.|. |.   .|.   .                                             . . .
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

ETHRVLHFTVFGWTETTTPIMQDFLALRKVMKDTGALNMinpasalfrstmrryihtppSFAPIIQSARGSSRAGAFVVIDLLIrmidgK-KtnlySVED
... ....  ..|   ..|... .| . . ...  ||.                     . . ..    | .|.|..|...|..     .      |.|.
lerlgiqylylpwpDhgvpllellleflefidellalsp....................ggpvlVHCsaGvgRtgtlvaaylml.....lgl....slee

LIVKCKHMRIHCVPVALHHSFIYE
 .   ...| ..|.   .. |.|.
avalvrekRpgavqnpsqyrflyy
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 33-283 2.7e-12 40.8 In-house 50-277 (439) alignment 
Range on Protein: 33-283
Range on HMM: 50-277/439.0
NRNRVVKIVPQHRYNVRL--TPSMlNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEkLEhydkYFPDKGDVWsYGH
 .||  ....    .| |  .| .     ||||  ..     . || | .|.....  ||..|.|... ||..... ||        |.| ...|  || 
tknrykdvgafdhtrvtlqeipgv.phshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlves.yk....ywpsdaevc.ygd

LQVeRKSYAIHQGNFHTRNFILR----KGNETHRVLHFTVFGWTETTTPIMQDFLAlrKVMKdtgALNMINPasalfrstMRRYihtPPSfapIIQSARG
. | |    |   |.  | | .     ...  . ||.|    | .   |    ..   . ..   |.|  |          . |    |    ... . |
iav.rvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvl..dflr...ainsand........keey...gpv...vvhcsag

SSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
  |.|. . .|. .  .  |  |   .. ..   .. | . |    .. |||.|||.
vGrtGtiialdialeql..klenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
0049772 (Phosphotyrosine protein) phosphatases II 29-287 3.2e-12 42.3 In-house 44-282 (314) alignment 
Range on Protein: 29-287
Range on HMM: 44-282/314.0
LEAVNRNRVVKIVPQHrYNVRLTPSMLNRDGYINASLMEFSdvgQKYILTGIPSEDKVFAF----------WQMVL--EQRSPTIIQ-------------
..  ..||  .|.|     |.|     .  .||||| .      .|.| |  |.|  |. |          |.|||  .... .|               
flnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrL

--------FADNVEEKlehydkyfpdkgD---VWSYGHLQverksyaihqgnfhtrnF-------IlrkgneTHRVLHFTVFGWTETTTPIMQDFLALRK
        . .  .              .   .. . .|.                                .......  . ..  ..|. .||... .
daAlgKtpllildgng............neptaadlellk.................eelydpelf......erlgikylripvpDgsaplledfdefle

VMKDTgalNminpasalfrstmrryihtpPSFAPIIQSARGSSRAGAFVVIDLLIRMIDgkktnlYSVEDLIVKCKHMRI-----HCVPVALHHSFIYEA
....    .                    .  . ..  . | .|.| |||...|..  .      .|.|. .   . .|      ....  ..  ||.||
fieea...d....................kggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilea

VLDYLLR
.|.|| .
lleylkf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 27-285 5e-12 40.3 In-house 29-295 (297) alignment 
Range on Protein: 27-285
Range on HMM: 29-295/297.0
ARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVG--QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KG
 |  .. .||  .|.  .   |.|  .. .|| ||||  . | |     ||||.  | .. |  ||..| ||   .|.  |   |.  .    |.|. ..
krnsslrknryrdilatddtrvkllrviterd.yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

DVWSYGHLQVERKSYA-IHQGNFHTRNFILRKGNETHRVLHFTVFGWTETTTP-IMQDFLAL-RKVMKD----TGALNMINPASALFRSTMRRY-IHTPP
.    |.. ||  |    .  . .  .. |   .|.  | |   ..| .   |  ..|   .  .|          | ...  .|.    .  .  . | 
erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

SFAPIIQSARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYL
.   ..  . |  |.|  |  | .. ..  .|  .  |  .. . .. |   |     . ..|.|||  |
nayllvhcsaGvGrsGvvvlsdvilakl..rkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 23-288 8.8e-12 39.8 In-house 40-291 (325) alignment 
Range on Protein: 23-288
Range on HMM: 40-291/325.0
ERVTARLEAVNRNRVVKIVPQHRYNVRL-TPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIqFADNVEEKLEHYDKYFPD
 .|... | ...||   .|. ..  | | |        ||||| ..     . .. .  |  . .  .|..||. |.. ..   . .... ..  .|.|.
kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpk

K-GDVWSYGHLQVERKSYAIHqGNFHTRNFILR--KGNETHRVLHFTVFGWTETTTPIMQDFLAlrKVmkdtgaLNMINPASALFRStmrryiHTPPSFA
. |.   .| |.|. ..      ..  | . ..  |. ||  |  | . .| .  ..     |.   .      |....  |   ..       |  |  
emgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatli..si......lqlvkavservta......ntkastp

PIIQSARGSSRAGAFVVID-LLIRMIDGKKTNLYSvedLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRR
 ..  . |  |.|.|. .  .| ..|.  . ...     . | .. |   |  .  ...||||. ....  
ilvhcsaGvGrtGvfislysalakvieesrvdifg...fvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 60-284 1.4e-10 35.3 In-house 83-282 (290) alignment 
Range on Protein: 60-284
Range on HMM: 83-282/290.0
YINASLMEfsDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQGNFHTRNFILRK--GN
|. |  ..   .   .|||  . .| |. .|.|||...  .|. . . .|.   . ..|.|.| |.| ..|.. |       .. |   . . .|.    
yvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsG

ETHRVLHFTVFGWTETTTPImqDFLALRKVMKdtgalnminpasalfrstmrrYIHTPPSFApIIQSARGSSRAGAFVVIDLLIRM-IDGKKTNLysvED
  |.. |. .  | . . .     ||| ....                      . . .    ..  . |  |.|.|| |.  ... .|||. .|    |
kehklkhlkikswpdksval..stlallrtlr.....................ilrkasGpv.vvhcsaGiGrtGtfvaievglqilldGkeldl...ld

LIVKCKHMRIHCVPVALHHSFIYEAVLDY
|.   .. |.  | | . .  . |..||.
lvralrnsrlnsvqvdiqylalveilldl
0046846 (Phosphotyrosine protein) phosphatases II 60-284 1.6e-10 36.5 In-house 14-172 (176) alignment 
Range on Protein: 60-284
Range on HMM: 14-172/176.0
YINASLMEFSdvgqKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkgdVWSYGHlqverksyaihqgnfhtrnfilrkgneth
||||.|.  |    ..| |  | .. . .|..|..|..  ... . . || .  . . |.|.   ....|.                             
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.............................

rvlHFTVFGWTETTTPIMQDFLALRKVMKDTGALNmiNPasalfrstmrryihtppsfaPIIQSARGSSRAGAFVVIDLLIRmidgkkTNLYSVEDLIVK
   .. ...| . ..| ....| | . ...    .  .|                     ..    | .|.|..|...||..       . .|||. . .
...qylhlpwpDhgvpdlelllellefirealkeg..gp....................vlVHCsaGigRtgtlvaayllel......ekglsveealal

CKHMRI-HCVPVALHHSFIYEAVLDY
 . .|  ..|.   .  |.||..| .
vreqRplgavqtpeQyrflyefelll
0051082 (Phosphotyrosine protein) phosphatases II 66-279 1.7e-10 36.2 In-house 6-147 (151) alignment 
Range on Protein: 66-279
Range on HMM: 6-147/151.0
MEFSDVGQKYILTGIPSEdkvfAFWQMVLEQRSPTIIQFADNVEEKleHYDKYFPDKGdvwsyghlqverksyaihqgnfhtrnfilrkgnetHRVLHFT
  ||.|.  ....| |..    .|.... |.   ||. . . .| .  .. .|.|. |                                   ..|||. 
infsyvtgglyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...................................ievlhip

VFGWTETTtpimqdflalrkvmkdtgalnmiNPASALFRSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMidgkktnlYSVEDLIVKCKHMRI
...|....                        | |  .   . ...  ...   ..    | .| |..|...|....        .|.|. .   . .| 
ildwpdpg.......................lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg........vsleealeeyrlkrp

HCVPVALHHSFIYE
..|    .. |.. 
gvvqpnqqflfqlf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 34-283 5e-10 33.9 In-house 10-238 (239) alignment 
Range on Protein: 34-283
Range on HMM: 10-238/239.0
RNRVVKIVPQHRYNVRLT-PSMLNRDGYINASLM-EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDvwSYGHL
.||  .||   .  | |   |   .  ||||| . ..    . || |    | .   ||.|. ..|   |. ..  .| . ..  .|.||      |  |
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnl

QVERKSYAIHqGNFHTRNFILRKGNETHR--VL--HFTVfgWTETTTPIM-QDFLALR-KVMKDTgalnminpasaLfrstmrryihtPPSFAPIIQSAR
.|  .   .   ..  | |.. .  .|    |   ||||  | .   |      | || |. ||.           |           | .   .|. . 
rvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkds...........l...........pgarpwvihcsa

GSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
|  |.|||.||| ..|    .||    . . .   .  | | |  . .. ||. |||.
gvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 34-283 6.2e-10 33.6 In-house 11-239 (239) alignment 
Range on Protein: 34-283
Range on HMM: 11-239/239.0
RNRVVKIVPQHRYNVRLT-PSMLNRDGYINASLM-EFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDvwSYGHL
.||  .||   .  | |   |   .  ||||| . ..    . || |    | .   ||.|. ..|   |. ..  .| . ..  .|.||      |  |
knryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts..kycnl

QVERKSYAIHqGNFHTRNFILRKGNETHR--VL--HFTVfgWTETTTPIM-QDFLALR-KVMKDTgalnminpasaLfrstmrryihtPPSFAPIIQSAR
.|  .   .   ..  | |.. .  .|    |   ||||  | .   |      | || |. ||.           |           | .   .|. . 
rvtlrktevf.adyiirtfvmsqvgqteeryvyqyhftv..wpdkgvpqyatavlglrrkitkds...........l...........pgarpwvihcsa

GSSRAGAFVVIDLLIRMIDGKKTnlYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLD
|  |.|||.||| ..|    .||    . . .   .  | | |  . .. ||. |||.
gvgrtgaflvidamlrqakkqkt..vdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 14-123 6.4e-10 33.3 In-house 30-154 (350) alignment 
Range on Protein: 14-123
Range on HMM: 30-154/350.0
LDDNQPLLSERVTARLEAVNRNRVVKIVPQHRYNVRLTPS---------MLNRDGYINASLMEFS------DVGQKYILTGIPSEDKVFAFWQMVLEQRS
 |.. |     ..  .|.  .|| . |.|  .  |.|  |          |. . ||||. .. .      . . ||| |  |    |  |....|.   
sdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkv

PTIIQFADNVEEKLEHYDKYFPDKG
. |.  ...||  || ...|... .
kvilsltsdvelnlekcyrYWqegs
subfamily_egg_pd Subfamily egg 7-284 8.5e-10 32.8 In-house 19-269 (307) alignment 
Range on Protein: 7-284
Range on HMM: 19-269/307.0
RSNIVHKLDDNQPLLSErVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFAD
| ...... |...|    ...      |.. |.     | ...|   .   | .| |  ..   .  ..||.  |  . |  ||.|| ... . |. .. 
rlevleesvdeisltta.asdnnlekarskrvhckdssrvklelrrGqyldd.fihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmlts

NVEEklehydkyfpdkgDVWSYGHLQVERKSYAIHQGNFHTRNFIL-RKGNETHRVLHFTVFGWTetttpimQDFLALRKVMKDTGAL-NMINPASALfR
..|              .   |   . | .|  .  |...  |. . .| .   || .. . |         .. . | .   |   . ..  |   | |
rkes.............erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.......deerflehwqgdvnnssdvysplrvl.r

StmRRYIHTPpsfaPIIQSARGSSRAGAFVVIDL-LIRMIDGkKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDY
    | . .|     ..|.  | |.|...| |.. |. .. |  .  . |   .|  .  |   |  .| . |.|  || .
k..lrnlskp....vvvqdilGvskaatlvaieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_hpo-7_pd Subfamily hpo-7 85-291 9.4e-10 32.8 In-house 46-233 (263) alignment 
Range on Protein: 85-291
Range on HMM: 46-233/263.0
KVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV-WSYGHLQVErKSYAIHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIM-QDF
.. .|.|..  ... ... ..|  ||  |. ..||| . |    . ...|   . ....   .|....   |   .|| | |.   || |.  |   .. 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvc.ttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelarei

LALRKVMKDTGALNMInPASALFRSTMrryihtppsfapiiqsargssragaFVVIDLL----IRMIDGKKTNLYSVEDLIVKCKHMRIHCVPVALHHSF
| . || ..   | .   ..   ||                           |.|..|.    || .|  .|       |. . ...|   ..  .. .|
lnilkvarnskslvvh.cstGiGrsaa.........................fsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

IYEAVLDYLLRRNPR
    |||..|  ...
silmvLdfvlnnfak
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 26-289 1.5e-09 32.3 In-house 38-275 (288) alignment 
Range on Protein: 26-289
Range on HMM: 38-275/288.0
TARLEAVNRNRVVKIVPQHRYNVRLTpsmLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGD
.. ...  |.|  ..       |.|.    . | ||.| ..  .   .. | .  | .  .  .|.|.||.    |. ... .|  .|. ..|||  .|.
dsfianptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGe

VWSYGHLqverksyaihqgnfhtRNFILRKGNETHRVLHFTVFGWTE-TTTPIMQDFLALRKVMKDTGALNMINPASALfrSTMrRYIHTPpsfaPIIQS
   .|.|                 . . .| .. ..... ...  .. . ....  .| |..  .|.   | . |   |    . . .. |     ...|
karigrl................ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrll..evl.kslqkP....ivvhs

ARGSSRAGAFVVIDLLIRMIdgKKTNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
  |. |.|....| . ....  . ..  ... |. | .  | ... .   . ...  ||..|| . 
saGvGrtgtlililialesl..rlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 57-182 2.1e-09 31.9 In-house 45-182 (290) alignment 
Range on Protein: 57-182
Range on HMM: 45-182/290.0
RDGYINASLMEFSDvGQKYILTGIPSEDK-------VFAFWQMVLEQRSPTIIQFADNVEEKLEHYD----KYFPDKGD-VWSYGHLQVERKSyAIHQGN
 |.|| |. . ... |.. |||  | |.        .. || |. . ..  ...  .. |.. .  .    ||.|.. .    .. |.|. ||  ... .
nddyiHAnrvtcpn.glrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCks.kekedd

FHTRNFILR-KGNETHRVLHFTVFGWTETTTPIMQ-DFLA
. ||. ...  ..| . | |  . ||... ..  .  .|.
vetRelvvkfddeeeftvtHsllkgWnklnvqedtktlls
PTPc_DSPc_SM00012 161-282 2.9e-09 32.4 In-house 2-104 (105) alignment 
Range on Protein: 161-282
Range on HMM: 2-104/105.0
VLHFTVFGWTETTTPI-MQDFLALRKVMKDTGALNMInpasalfrstmrryihtppSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKtNLYSVEDLIVK
| |. . ||... .|  ....| | . .|.    .                     |   ....  | .|.| ||..|.|..... .. . ....... .
vkhyhytgwpdhgvPeesdsilellravkknknkses...................skpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivke

CKHMRIHCVPVALHHSFIYEAVL
 ...| ..|      .|.|.|.|
lrkqRpgmvqteeqylflyrall
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 30-286 4.3e-09 30.4 In-house 46-280 (303) alignment 
Range on Protein: 30-286
Range on HMM: 46-280/303.0
EAVNRNRVVKIVPQHRYNVRLTPSmlnrdGYINASLMEFsDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDVwsyg
. ...|| | ..     .|.|. |      || || .|. |  .| ||| .|       ||||..||.   .. .  . | .    |  || . |     
knmdknrfvdvicldhskvklsds.....syihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf....

hLQVERKSyaIHQGNFHTRNfiLRKGNEtHRVLHFTvFGWTETTTPIMQDFLALRKVMKDTGALNMINPASAlFRSTMRRYIHTPPsfaPIIQSARGSSR
 |. | .|  |  |.|.  .  | .|    .||  .  |   .   . .      . .   |. ....      .| .|.| .. |   ..  |  |  |
.lkfeers..irvgefkrve..lgdgwv.lkvlsvs.ngdyksflhvhhykawphnsipsdgspkfvkqiwq.lqsvlrkysdstp...tvymslsgcgr

AGAFVVIDLLIRMIDGKKTNLYSVEDLiVKCKHMRIHCVPVALHHSFIYEAVLDYLL
||.| ...     .  ... |  |  |  . .  |.|.|      |..|  . ...|
agtfalfetahlslhseqasldlvkcl.envrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 31-289 4.6e-09 30.7 In-house 41-281 (307) alignment 
Range on Protein: 31-289
Range on HMM: 41-281/307.0
AVNRNRVVKIVPQHRYNVRLTPSMLNRDgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGDVWSYG
  ..||   .  |..  . .. . |  | || |  .  .   .|.| .  | |. .. || |.....  ..| ... .|    . ..|.|  .|.   .|
ntdknryqdvkcqdkgrivvkfdglasd.yihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfg

hlqveRKSYAIHQGNFHTRNfiLRKGNETHRVLHFTVfGWTETTTPIMQdfLAlRKVMKDTGALNMINPASALFRSTmrRYIHTPpSfapIIQSARGSSR
      .. .|   |. ...  |   ..   |  . |  |.. .  | .  |   .   | |. ..   |  |. ..  || . |     ..  . |  |
.....eapntisvanlgakk..lapdedlinvttlkv.dwaqksrtiqh..lq.wenwpdrgvpqinltainlleav..rydtnp.v...vvhcsaGvGr

AGAFVVIDLLI-RMIDGKktNLYSVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLLRRN
.|. | | |.  .||.|.  |  ....|. . .  | ...   . . ...  .|.|.| . 
sGtivaislvqdkmiaGi..nckdmkklveelrsqrhyaiqteaqylylhrvlleyflely
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 203-286 7.8e-09 30.0 In-house 195-277 (281) alignment 
Range on Protein: 203-286
Range on HMM: 195-277/281.0
FRSTMRRYIHTPPSFAPIIQSARGSSRAGAFVVIDLLIRMIDGKKTNLySVEDLIVKCKHMRIHCVPVALHHSFIYEAVLDYLL
||. .... ..    . .|  . |  |.|... .| |.. .. ....| .|.... . .. |   |   . ..|.| ||||.| 
frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleel.dvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 30-140 1e-08 29.3 In-house 41-153 (301) alignment 
Range on Protein: 30-140
Range on HMM: 41-153/301.0
EAVNRNRVVKIVPQHRYNVRLTPS-MLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD-KGDVWS
.|.||.. .......|  .. .|.  | .  ||||| ..     .|.| .  | .  .  ||.......  .|.  ..  |.. ..  .|.|. . .  .
kalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaesee

YGHLQVERKSYAI
.|...|. .. ..
fgpftvtlvneqv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 73-181 1.1e-08 29.6 In-house 5-117 (199) alignment 
Range on Protein: 73-181
Range on HMM: 5-117/199.0
QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQgNFHTRNFILRK----GNETHRVLHFTVF
..|| |  |  . .  ||||| |  |  |.   |.  .|   |  |.|     .  || | |  |. . .  ..    .|| .       |  . |.   
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dytitaliltnnttappstreishyqft

GWTETTTPIMQDFL
 | | ||| .  |.
swkekttpnvalfv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 73-181 1.1e-08 29.5 In-house 4-116 (198) alignment 
Range on Protein: 73-181
Range on HMM: 4-116/198.0
QKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKSYAIHQgNFHTRNFILRK----GNETHRVLHFTVF
..|| |  |  . .  ||||| |  |  |.   |.  .|   |  |.|     .  || | |  |. . .  ..    .|| .       |  . |.   
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkp.dytitaliltnnttappstreishyqft

GWTETTTPIMQDFL
 | | ||| .  |.
swkekttpnvalfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 85-189 1.6e-08 29.0 In-house 40-147 (255) alignment 
Range on Protein: 85-189
Range on HMM: 40-147/255.0
KVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGD-VWSYGHLQVERKSyAIHQGNFHTRNFILRKG--NETHRVLHFTVFGWTETTTPIM-QDF
 | .|.|..  ... ... ..|  ||. |. ..||| . |    . ...|     .. .  ..|.. ..  |   .|| | |..  || |  .| . .. 
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelarei

LALRKVMKD
| . ||..|
lnilkvvrd
0044763 (Phosphotyrosine protein) phosphatases II 56-284 1.7e-08 29.8 In-house 11-170 (178) alignment 
Range on Protein: 56-284
Range on HMM: 11-170/178.0
NRDGYINASLMEFSDVGQKYILTGIPSedkvFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDvwsyghlqverksyaihqgnfhtrnfilrkg
|. |.  .  . .| .   ..|.. |.     ...... |.   .|. .....|   ...|.|.|.. .                               
nleglersdyinaseilpglylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag...............................

netHRVLHFTVFGWTETT-TPIMQDFLALRKVMKdtgalnminpasalfrstmrryihTPPSFAPIIQSARGSSRAGAFVVIDLLIRMidgkktNLySVE
    ..||. . ...... . ....|... .                            ..  . ..    | .|.|..|...|....      .| |.|
...iqylhipipDhgvpdllehflefvefieeal........................dekggpvlVHCsaGvgRsgtlvaaylmkkl......gl.sle

DLIVKCKHMRIhCVPVALHHSFIYEAVLDY
. |   . .|  .||   .  ..||  | .
eaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 22-135 8.2e-08 26.1 In-house 43-156 (310) alignment 
Range on Protein: 22-135
Range on HMM: 43-156/310.0
SERVTARLEAVNRNRVVKIVPQHRYNVRLTPSMLNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPD
|    |  . . .||   .| .    |.|.      . || |  .    . . .| .  | .  .  ||.|....|. .|. .   .||   .   |.| 
sltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps

KGDVWSYGHLQVER
 |   .|| ..|  
lgvtetygcirvtn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 33-157 9.8e-08 26.3 In-house 35-153 (267) alignment 
Range on Protein: 33-157
Range on HMM: 35-153/267.0
NRNRVVKIVPQHRYNVRLTPSMLNrdgYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHydkYFPDK-GDVWSYGHL
.|||. . .| .   | |  .  .   ||||| .|    ....|.| .| .  .  |.... .|. |.|.      ....     ..| | |.   |  |
ernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPkmgqakkyqdl

QVERkSYAIHQGNFHTRNFILRKGNE
 ||. |    . ...   . |.  ||
tveh.slekeendyqiitlelkfkne
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 34-181 1.2e-07 25.7 In-house 40-189 (281) alignment 
Range on Protein: 34-181
Range on HMM: 40-189/281.0
RNRVVKIVPQHRYNVRLTPSML--NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDKGDV-WSYGH
.|| ..|       |.|   |   |   || |  .    . . ||||  | ..    ||.|. .. . .|. ... .| . |.  .||| .  .   . .
knrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdk

LQVERKSYAIHQGNFHTRNFiLRKGNETHRVLHFTVFGWTETTTPIMQDFL
| |. .  .. .    ||   |    ||. . |.    | .   |   . .
lsvsyedstvnkslvttrln.lsyegetrlithwlwkewpdwqvpessevm
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 42-125 1.5e-07 25.3 In-house 107-184 (244) alignment 
Range on Protein: 42-125
Range on HMM: 107-184/244.0
PQHRYNVRLTPSMLnRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIqFADNVEEKlehyDKYFPDKGDV
|     | |. . .  . |||||..       .||||  |  |  . ||.|.||.    ..     |||.    |.|.||   .
pfdfnrvplskgsm.gntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlv.vlgsveee....deywpdsepl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 55-114 1.5e-07 25.2 In-house 67-127 (347) alignment 
Range on Protein: 55-114
Range on HMM: 67-127/347.0
LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQ-FADNVEEKLEH
 . ..||||| . | .  ..||||  |  | |  ||.||   .   ..  |    .| .| 
ddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 56-136 1.6e-07 25.0 In-house 73-156 (302) alignment 
Range on Protein: 56-136
Range on HMM: 73-156/302.0
NRDGYINASLMEFSDVGQKYILTGIPSEDKV---FAFWQMVLEQRSPTIIQFADNVEEKLeHYDKYFPD-KGDVWSYGHLQVERK
. | |.||| .|  ..... ||. .|  | .     ||.|| ...  ..   . . | |    ...||   ||   ||.. |  .
epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 57-122 1.8e-07 24.8 In-house 89-156 (349) alignment 
Range on Protein: 57-122
Range on HMM: 89-156/349.0
RDGYINASLMEFS--DVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK
 | ||||  ....  .| .||| | .|.   |  |....| .. . ..   |. |. || .|.|. . 
lddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_ptpA1_pd Subfamily ptpA1 30-126 7.2e-07 23.3 In-house 46-144 (418) alignment 
Range on Protein: 30-126
Range on HMM: 46-144/418.0
EAVNRNRVVKIVPQHRYNVRLTPsMLNRD--GYINASLMEFSdVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK--GDV
   ..||  .|.|  .  |.|   . ...   ||||  .. .   ...| |  |  . .  ||.|| |.|   |. .. . |.   . |.|.|..  |. 
hntsknrytnilpvnhtrvqlkk.iqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeq

W
.
f
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 63-175 7.8e-07 23.1 In-house 80-197 (301) alignment 
Range on Protein: 63-175
Range on HMM: 80-197/301.0
ASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDK-GDVWSYGHLQVERKS-YAIHQGNFHTRNFILRKG---NE
|  .. |   ...| |  | ..    || |.      .|. .. .||.. |. ..|.| | ..    |  ... |.   | . . . |.. ..      .
anwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfa

THRVLHFTVFGWTETTTP
|. |.|.    ||.  .|
trtvthyqysewtdrgvP
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 55-122 2.1e-06 22.1 In-house 10-72 (130) alignment 
Range on Protein: 55-122
Range on HMM: 10-72/130.0
LNRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSpTIIQFADNVEEKlehyDKYFPDK
|. . |||||..  ..  ..|.||  |  |.   ||.|.||.    ..     |||.    |.|.|| 
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryv.nvlvvlgsveee....deywpds
0049260 (Phosphotyrosine protein) phosphatases II 69-278 2.8e-06 22.6 In-house 5-143 (152) alignment 
Range on Protein: 69-278
Range on HMM: 5-143/152.0
SDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFpdkgdvwsyghlqverksyaihqgnfhtrnfilrkgnethrvlhftvfg
   ....| |  | .  .  ||.|. |.   ||.   . .| . .  ..|.                                                 
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................

wtetttpimqdflalrkVMKDTGALNMINPASALFRSTMRRYI---HTPPSFAPIIQSARGSSRAGAFVVIDLLIrmidgkktNLYSVEDLIVKCKHMRI
                   . .    .  | .. .   . . |      ..   ..    | .|.|..|...|..        . .|.|. .   . .| 
.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRp

HCVPVALHHSFIY
. ||   .  |.|
gavpnpgqlrfly
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 56-287 3.4e-06 21.0 In-house 65-278 (312) alignment 
Range on Protein: 56-287
Range on HMM: 65-278/312.0
NRDGYINASLMEFSDVGQKYILTGIPSEDKVFAFWQMVLEQRSPTIIQFADNVEEKLEHYDKYFPDkgdVWSYGHLQVERkSYAIHQGNFHTRNfiLRKG
. . || | ..      .... |  | |. .  |||..|   | .|| ..  ||.  |.  ||  |   . .. .|.  |  |. .  .         | 
denfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd...ivgfvdledhr.vyteycteieigg..kskd

NETHRVLHFTVFGwTETTTPIMQDFLAlrkVMKDTGALNMINPASALFrSTMRRyiHTPPSfapIIQSARGSSRAGAFVVIDLLIRMIDGKktNLYSVED
. |||||.  |   |   . . .   |      | |  .  . |  |. |....     |    | . . |  |.|....|. .|  .         | |
kithrvlkvvvka.tgqesklnhyqwa...swpdhgmpdscdtalrll.savkk..dkkpv...iahcsagvgrtgtlaliesmiaalrhp..rkqnvkd

LIVKCKHMRIHCVPVALHHSFIYEAVLDYLLR
  |  .. |   | |  .. .   .||..|  
sfvllrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 29-123 9.4e-06 19.3 In-house 32-126 (332) alignment 
Range on Protein: 29-123
Range on HMM: 32-126/332.0
LEAVNRNRVVKIVPQHRYNVRLTPSMlNRDGYINASLMEFSDVGQKYILTGIPSEDKV-FAFWQMVLEQRSPTIIQFADnVEEKLEHYDKY-FPDKG
|. .. ||. ..    .  | |.|    .| . ||| ..       ||..  | .|.  . ||.|| |..   |. | | ..|| ..   |   |.|
lnnmdmnriphlycfdhsrvelapqd.gkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd.idekqkrkapydisdrg