Gene T04F3.3 in Caenorhabditis elegans

Synonym: CELE_T04F3.3, T04F3.3

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP181_AA protein Get Run
CeleP181_AA_45-342 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0036941 (Phosphotyrosine protein) phosphatases II 54-340 1.4e-51 170.9 In-house 6-281 (297) alignment 
Range on Protein: 54-340
Range on HMM: 6-281/297.0
FIKLLSTSSVGKEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAvHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSL
..|||... . |||... .| |.  ..| .. .. |.|..  |  |..|||.  . .|..| | |..|||. .||||..  |....|. |||.|.. |. 
lekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvt

IVVTLCELLD---EKGKPFVPVKIGEPLVIDDMTIELDNIRKV-RPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTIL
..|.|.|| .   ||  .. | ..||.|. .|.|..| .. .|  .     .|... .| . ..||  . | ||   | |. |...||..  .....  |
vIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkll

rkqglekkifddSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASheIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHH
             . .|.   | .| .||.|..|.|...|.|  .  . .. ||||...  ||. |  |.   ||..|| . .||.  .. 
............psggpvlVHCsaGvgRsgtfiaadlmlqqledk..lkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0050432 (Phosphotyrosine protein) phosphatases II 43-338 2.1e-49 163.9 In-house 24-301 (308) alignment 
Range on Protein: 43-338
Range on HMM: 24-301/308.0
TKNACTRPLDIFIKLLSTSSVGKEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAvhRQGHNYLNSSWIDGY--RETRKFIVAPSPMSESV
.|  .   | .. |.|... . .|| .. |.. .. ..| .. .. ..| .  |  |...||.    .|..| | |..|||  . .||||.. .|....|
lklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntv

AQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIG-EPLVIDDMTIELDNIRKvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDIL
. ||| |.. |. ..|.|..| .   ||  .. | ..| ..|.....|..| .. . ..     .|... .| .  .||  . | .|   | |..|...|
edFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeill

DLLADMNHMRtilrkQGlekkifddsqrTPMTLVCFDGFSRSCTLVALDILCQRLTASheigtPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
|.|  .....     .|            |.   | .| .|..|..|||.|...| .        ||.......||. |  .    ||..|| . .|||.
dflelvrksl.....pg...........gpivVHCsaGvGRtGtfialdllleqleke.....ggvdvfeavkklReqRpgmvqtpeqylflyralleyl

IR
 .
kl
Y_phosphatase Protein-tyrosine phosphatase 89-334 1.5e-48 160.7 Pfam-A 3-235 (235) alignment 
Range on Protein: 89-334
Range on HMM: 3-235/235.0
ELNKFGEIQVYEQTRVRAVHRQG-HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDDMT
. |.. .| .|..|||.  ...| ..| | ....||.|..|||..  |.......|||.|..... ..|.|..| .   || ....| . .|.|  .|..
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IELD-NIRKVRPATYSSVLKISEKGVES-HKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifdDSQRTPMTLVCFDGFSRSCTLV
.||  .. .   ..  ..|....|. || ...|  | | .| . | |..|...|||. .... .              .....|.. .| .| .|..|.|
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..............eaksgpvvVhCsaGvgRtgtfv

ALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
|||||...|.| .|     ||.|... .||  |  .. ..||..|| . .||
aldilleqleaeee.....vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 89-334 1.5e-48 160.7 In-house 3-235 (235) alignment 
Range on Protein: 89-334
Range on HMM: 3-235/235.0
ELNKFGEIQVYEQTRVRAVHRQG-HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDDMT
. |.. .| .|..|||.  ...| ..| | ....||.|..|||..  |.......|||.|..... ..|.|..| .   || ....| . .|.|  .|..
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IELD-NIRKVRPATYSSVLKISEKGVES-HKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifdDSQRTPMTLVCFDGFSRSCTLV
.||  .. .   ..  ..|....|. || ...|  | | .| . | |..|...|||. .... .              .....|.. .| .| .|..|.|
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk..............eaksgpvvVhCsaGvgRtgtfv

ALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
|||||...|.| .|     ||.|... .||  |  .. ..||..|| . .||
aldilleqleaeee.....vdvlqivkelRkqRpgmvqsleqYiflykaile
0047943 (Phosphotyrosine protein) phosphatases II 56-336 1.2e-47 158.1 In-house 7-272 (273) alignment 
Range on Protein: 56-336
Range on HMM: 7-272/273.0
KLLSTSSVGKEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAvHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIV
|||... . .|| .. ||. .  ..| .. .. ..| .  |  |...||.  . .|..| | |..|||. .||||..  |....|. |||.|.. |. ..
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VTLCELLD---EKGKPFVPVKIGE-PLVIDDMTIELDNIRKvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRK
|.|.|| .   ||  .. | . || .|. ...|..| .. . ..  .  .|... .| .  .||. . | ||   | |. ....|... ......  |..
VmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealps

QglekkifddsqrTPMTLVCFDGFSRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
.            .|.   | .| .|..|..|||.|...| . .      ||.|.....||. |  . .  ||..|| . .|||.
n............gpvvVHCsaGvgRtgtfialdllldqlekeg.....gvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 60-339 1.7e-47 157.6 In-house 17-279 (317) alignment 
Range on Protein: 60-339
Range on HMM: 17-279/317.0
TSSVGKEFSHFSSLPLSrLRTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVV
   . .|| .. ||.|.  ..| .. .....| .  |  |...||.  . .|   ..| | |..||....||||.. .|....|. |||.|.. .. ..|
ftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtviv

TLCELL---DEKGKPFVPVkiGEPLVIDDMTIELDNIRKvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqg
.|.||    .||  .. |   ||.|...|.|..| .. .  .     .|... .| . . ||  . | ||   | |. |...||.|  ... .       
mLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal.......

lekkifdDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRH
       ... .|.   | .| .|..|..|.......|   .     .||. .....||. |. |.   ||..|| . .|||  |.
.......edpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.....gvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0051299 (Phosphotyrosine protein) phosphatases II 60-336 9.6e-47 155.2 In-house 22-286 (288) alignment 
Range on Protein: 60-336
Range on HMM: 22-286/288.0
TSSVGKEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVV
.. . .|| .. ||  .. ... ..  . | |..  |  |...||.  . .|   ..| | |.||||. .||||..  |....|. ||| |.. |. ..|
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

TLCELLD---EKGKPFVPVkiGEPLVIDDMTIELDNIRKvRPATYSSVLKISEK----GVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTil
.|..| .   ||  .. |   |..|...|.|..| .. .  .     .|... .    | . ..||. . | .|   |.|. |...||.| ......   
mltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..

rkqglekkifddSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
            |.  |.   | .| .|..|..|||.|...| . .      ||.|....|||. |  ..   ||..|. . .|||.
............sgggpvvVHCsaGvgRtgtfialdllleqlekeg.....gvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0046845 (Phosphotyrosine protein) phosphatases II 68-339 1.4e-46 154.6 In-house 7-277 (284) alignment 
Range on Protein: 68-339
Range on HMM: 7-277/284.0
SHFSSLPLSR--LRTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQG----HNYLNSSWIDGY-----RETRKFIVAPSPMSESVAQFWRCVFDRNSLIVV
 .  ||  ..   ..| ..  . ..|..  | .|...||.  . .|    ..| | |..|||     . ..|||..  |....|. |||.|.. |. ..|
eellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIV

TLCELLDE---KGKPFVPVKiGEPLVIDDMTIELDNIRKvRPATYSSVLKISEKG-VESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTIlrkq
.|.|| .    |  .. | . ||.|...|.|..| .. . ..     .|... .|  . ..||. . | .|   | |. |.|.|..| .......     
mltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen....

glekkifdDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHeiGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRH
         ..  |.   | .| .|..|..|||.|...| . .   .  ||.|....|||. |  .    ||..|. . .|||. ..
........lpgggpivVHCsaGvgRtGtfialdllleqlekeg..lllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 85-336 2.1e-46 153.8 In-house 23-262 (263) alignment 
Range on Protein: 85-336
Range on HMM: 23-262/263.0
FDH-PELNKFGEIQVYEQTRVRAVHRQ---GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEP
...  . |.. .| .|..|||.  ...   |..|.| ..|.|.....|.|..  |... |..|||.|..... |.|.|.|  .   || . ..| ..|..
kkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggk

LVIDDMTIELDNIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILrkqglekkifddsqRTPMTLVCFDGFSR
 ........| .  |..  .   .|.....| | ...|  . | .| . |.|......|.||  ... .                  .|.  .| .| .|
etfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..............sgpivVhCsaGvgR

SCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
..|.|..||....|.. ..     ||| ... .||. |  .. . ||. |. . .|||.
tgtfvtidiilskleeekk.....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 85-336 2.1e-46 153.8 In-house 23-262 (263) alignment 
Range on Protein: 85-336
Range on HMM: 23-262/263.0
FDH-PELNKFGEIQVYEQTRVRAVHRQ---GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEP
...  . |.. .| .|..|||.  ...   |..|.| ..|.|.....|.|..  |... |..|||.|..... |.|.|.|  .   || . ..| ..|..
kkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggk

LVIDDMTIELDNIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILrkqglekkifddsqRTPMTLVCFDGFSR
 ........| .  |..  .   .|.....| | ...|  . | .| . |.|......|.||  ... .                  .|.  .| .| .|
etfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts..............sgpivVhCsaGvgR

SCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
..|.|..||....|.. ..     ||| ... .||. |  .. . ||. |. . .|||.
tgtfvtidiilskleeekk.....vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0043336 (Phosphotyrosine protein) phosphatases II 59-335 7e-43 142.5 In-house 18-276 (278) alignment 
Range on Protein: 59-335
Range on HMM: 18-276/278.0
STSSVGKEFSHFSSLPLsRLRTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIV
. . . .|| .. | .|   ... .. .. ..| .  |  |...||.  . .|   ..| | |..|||. .||||..  |..|.|. ||| |.. .. ..
lktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvtti

VTLCELLD---EKGKPFVPvkiGEPLVIDDMTIELDNIRKvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkq
|.|.|| .   .|  .. |   |..|...|.|..| .. .  .     .|... .|    .||  . | ||   | |  .|..||.| ......      
vmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal......

glekkifdDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
        ... .|.   | .| .|..|..||..|...|   .     .||.......||. |. |..  .|..|| . .|||
........edsngpvlVHCsaGvgRTGtfialyllleqlekeg.....gvdleeavkelreqRpgavqtpsqyrflyealley
0045450 (Phosphotyrosine protein) phosphatases II 67-335 9.4e-43 142.5 In-house 33-303 (307) alignment 
Range on Protein: 67-335
Range on HMM: 33-303/307.0
FSHFSSLPL--SRLRTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQG----HNYLNSSWI--------DGYRETRKFIVAPSPMSESVAQFWRCVFDRNS
| .. |.    .  ... ..  . ..| . .|  |..|||.  . .|    ..| | |..        |||. .||||.. .|..|.|. ||| ... ..
fekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgv

LIVVTLCELLdEKGK----PFVPVKiGEPLVIDDMTIELDNIRKvRPATYSSVLKISEK-GVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRT
 ..|.|.||  |.|.    .. | . ||.|.....|..| .. .  .     .|... . | . . ||. . | ||   | |. ....||..  ..... 
tvivmltelv.elgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

IlrkqglekkifdDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEIgtPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
             ... .|.   | .| .|..|..|.......| . ...  ..||.|.....||. |. |.   ||..|| . .||.
e............lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtl..ldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 54-338 7.4e-42 139.2 In-house 25-291 (297) alignment 
Range on Protein: 54-338
Range on HMM: 25-291/297.0
FIKLLSTSSVGKEFSHFSSLPLSrlRTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQG----HNYLNSSWIDGYRE-TRKFIVAPSPMSESVAQFWRCVF
..|..|.. . .|| .  ||. .  ... ..  . ..| . .|  |...||.  .  |    ..| | |..|||.  |||||..  |..|.|. ||| |.
lekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

DRNSLIVVTLCELLDE--KGKPFVPVKIGeplVIDDMTIELDNIRKvRPATYSSVLKISEKGVEshKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMR
. .. ..|.|..| .   |  .. | . |   . .|.|..| .. . ..  .  .|... .| .  .||  . | ||   | |. ....|..|  ... .
eqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnnges..rtvthfqytgwpdhgvppslellleflelvreal

TILrkqglekkifddSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASheigtPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIR
  |            .. .|.   | .| .|..|..|.......|          ||.|.....||. |. |..  .|..|| . .||.  |
ael............pkggpvlVHCsaGvgRtGtfiaaylmleqleke.....ggvdvleavkelreqRpgavqtpsqyrflydallellkr
0040439 (Phosphotyrosine protein) phosphatases II 81-336 3.5e-40 133.6 In-house 5-246 (249) alignment 
Range on Protein: 81-336
Range on HMM: 5-246/249.0
VDAFFDHPELNKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL---DEKGKPFVPVki
|  .  ....| .  |  |...||.  . .|   ..| | |.||||. .|.||..  |..|.|. ||| ... .. ..|.|..|     ||  .. |   
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl..

GEPLVIDDMTIELDNIRKvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILrkqglekkifddSQRTPMTLVCFDG
|..|...|.|..| .. .  .  .  .|... ..  .. ||  . | .|   | |. ..|.||..  ...... |            .. .|.   | .|
ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel............pkggpvlVHCsaG

FSRSCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
 .|..|..|.......|   ..     ||...... ||. |. |..  ||..|| . .||. 
vgRtGtfiaaylmleqlekelg.....vdleeavkllrsqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 79-337 4.7e-39 129.8 In-house 25-273 (278) alignment 
Range on Protein: 79-337
Range on HMM: 25-273/278.0
RTVDAFFDHPELNKFGEIQVYEQTRVRavhrqghNYLNSSWIDGYreTRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPvKiG
 |.  . .. ..|.. .|. |...||.       .|.| |.||||  ..|||..  |. . ||.|||.... .. ..|.|.||..    |  .. |   |
itpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp.e.g

EPLVIDDMTIELDNIRKVrPATYSSVLKISEK----GVESHKTVILLTYSGWGKLGYPQKP--SDILDLLADMNHMRTILRKQGLEKKIFDDSQrTPMTL
..|...|.|..| ..  . .  .  .|..             .|  | | .|   | |  |  . .|.||  ... .  | .. |  ....||. .|.  
gsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsg.gpvlV

VCFDGFSRSCTLVALDILCQRLtasheigTPFVDILDTIARLRMLRGA-ACMKAEQFVFLSMSVLEYAI
 |  | .|..||||.......|        . ||.|.... ||. |.  |..  ||..|| . .||.  
HCsaGvgRtGtlvaaylmlell.......eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0042113 (Phosphotyrosine protein) phosphatases II 82-335 2.3e-37 124.1 In-house 4-242 (245) alignment 
Range on Protein: 82-335
Range on HMM: 4-242/245.0
DAFFDHPELNKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVkiG
 ..  ....| . .|  |..|||.  . .|   ..| | |..|||| |.|||..  |..|.|. ||| ... .. ..|.|.|. .   .|  .. |   |
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..g

EPLVIDDMTIELDNIRKvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTIlrkqglekkifddSQRTPMTLVCFDGF
|.|...|.|..| .. .  .  .  .|... .|   ...|| . | .|   | |  ....||.|  ... .               .. .|.   | .| 
esltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.............dsngpvlVHCsaGv

SRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
.|..|..|.......| . .      |.. .....||. |. |..  .|..|| . .||.
gRtGtfiaaylmleqlekel.....gvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPRD_pd Subfamily PTPRD 91-336 1e-34 115.1 In-house 52-281 (564) alignment 
Range on Protein: 91-336
Range on HMM: 52-281/564.0
NKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKiGePLVIDDMT
| . .|  |...||.       .| .| | |.|||||. ...| .  |..|... ||| |...|| ..| | .| .   .| . . | | | .  ....|
NRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygelt

IELDNIRKVRPATYsSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTilrkqglekkifddSQRTPMTLVCFDGFSRSCTLVAL
..| .  ..   .    .|...|  .. ..|    .  |   | |... ..|||. .......              ... |..  |  |  |. | ...
Vtleeeeeladyei.rtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne..............pdagPivVhCSaGVGRTGtfivi

DILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
|.. .|.....      |||  ....||  | |   . ||..|.   .||. 
damlerikeekt.....vDiyqyvkalrkqRnamVqteeQYiFiheaileal
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 91-339 1e-30 101.9 In-house 50-283 (318) alignment 
Range on Protein: 91-339
Range on HMM: 50-283/318.0
NKFGEIQVYEQTRVRAVHR---QGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELlDEKGK----PFVPVKigEPLVIDDM
|..  |  |..|||.  ..   .| .|.|...|||||.....| | .|..| .  ||| |...|| ..|.| ..  |.||     . | |  ..  ....
nryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqe.eergkakvhryWPsk..gsrsygkl

TIELDNIRKVRPATYSsVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTilrkqglekkifdDSQRTPMTLVCFDGFSRSCTLVA
..||..  ..   .    .|......|....|    |  |   | |......|||. . ... .             .|...|..  |  |  |  . .|
vvelkeevelsdyvlr.efkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq.............ksgagpivvhCsaGvGrtGvfia

LDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRH
.||| .|. |        ||...|. .||  | .     .|..|.   .||. .  
vdillerikaea.....lvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_Ptp69D_pd Subfamily Ptp69D 91-337 2.2e-30 100.8 In-house 52-287 (307) alignment 
Range on Protein: 91-337
Range on HMM: 52-287/307.0
NKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGK---PFVPVKigEPLVIDDMT
|.. .|. ...|||.  . .|    .|.|.|.| ||.|..|||.|  |. . .  ||| . . .. ..| | .| . . |    . |.   .    .|. 
nRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdil

IELDNIRKVRPATySSVLKISEKG-----VESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILrkqglekkifddsqRTPMTLVCFDGFSRSC
..| . .|    .    |..|.|.     || .. |.   | ||     |. .  .|.|.  ....                  |.|... |  | .|| 
vklvseekhsdyi.iReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln..............rsPivvhCsaGvgrsg

TLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
..||||.| |.| | ..     ||| .|.  ||  |     . ||.|||  ..|.|  
ifvaldsllqqlkaedk.....vdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPRB_pd Subfamily PTPRB 66-336 5.9e-30 99.3 In-house 30-285 (293) alignment 
Range on Protein: 66-336
Range on HMM: 30-285/293.0
EFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL
|.......  ..  ...      . |.. .|  |...||.     ...| .|.|...|.||. .|.||..  |. |.| .||| |....| |.| | .|.
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlv

dEKGK----PFVPVKIgEPLVIDDMTIELDNIRKVRPATYSsVLKISEkgVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilrkqglEKKI
 ||||     . | .  || .  |....| . ....  .    |||..   .....|  . .  |   | |.|.. .||..  .            ...|
.ekgkvkCeeYWPade.epvlyGdikvtlvaeeeledwvir.elkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtv............reai

FDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTAsheigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
 ......|..  |  |  |. |..||| | |...      . .|||. ..|.||. |       .|..|.  .||.. 
ektaskrPivvhCsaGvGRtGtfialdrllqaiee.....edyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 89-335 1.8e-29 98.0 In-house 58-289 (298) alignment 
Range on Protein: 89-335
Range on HMM: 58-289/298.0
ELNKFGEIQVYEQTRVRAVH---RQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVKIGEplVIDD
. |.. .|  ....||.  .    .  .|.| |....|...  ||..  |. |.|..||| | ....  .| | .| .    | . . | .  |    ..
kkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tyge

MTIELDNiRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifDDSQRTPMTLVCFDGFSRSCTLV
.|..| . ...     .  ||.|.| .|....|  | .. |   | |.. . .||||.... ..              ..  .|... | .|  || | .
itvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasq.............qqagnkpvivqCsaGvgRsGtfi

ALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
|.| . .|. ...      ||..... .||. | .|    ||.||. . |||.
aidsvlervkkeqv.....vDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 87-335 2.9e-29 97.2 In-house 46-282 (305) alignment 
Range on Protein: 87-335
Range on HMM: 46-282/305.0
HPELNKFGEIQVYEQTRVRAVHRQGHN---YLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLC---ELLDEKGKPFVPVKIGEPLVI
. . |.. ||..... |..  ... ..   |.|.|..|||..  |.||| .|. . ||.||| ...     .| |.   |  ..| . . | ...|.  .
nkaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkef

DDMTIELDNIRKVRPATySSVLKISE-KGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNhmrtilRKQglekkifDDSQRTPMTLVCFDGFSRSC
.....|| . ...   .    ||||  .. .  .||. .    |   | ||... .|.|. ...      ..|         .. .|.. .| .| .|. 
gefsvelksektasdyi.eRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq......kdq.......kkdkgvpllVhCsagvgRtG

TLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
. .|.||  .|| .  .     ||. . . .||  |  .  . .|.|||   . |.
vfiavdialerlkkEev.....vdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN9_pd Subfamily PTPN9 90-340 7.4e-29 95.7 In-house 45-294 (297) alignment 
Range on Protein: 90-340
Range on HMM: 45-294/297.0
LNKFGEIQVYEQTRVRAVHRQGH---NYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEplVIDDM
 |.. ..  |..|||   .....   .|.|....|||.. . || .  |. . |  ||| |.... |..|    ...    | . . | . ..  ...  
knrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleees..saefg

TIELDNIRKVRPATY-SSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRKQgLEKKIFDDSQRTPMTLVCFDGFSRSCTLV
 ... |.  .    |  .||.|..   | ...|.   . .|   | |.  ...||.|  . .... . |. | ..   . .  |. . |  |  |. |..
dlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke.lgdewkghpsgPPivvhcsaGiGrtGtfi

ALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHH
.|||  .||          ||. .|. .||  |  .    ||..|  ..|||||....
tldiclsrleevgt.....vdvvetvkllrtqrafsiqtpeqyefcylavleyalelk
subfamily_PTPN12_pd Subfamily PTPN12 90-345 1.2e-28 94.9 In-house 43-285 (290) alignment 
Range on Protein: 90-345
Range on HMM: 43-285/290.0
LNKFGEIQVYEQTRVRAVHRQ---GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDDM
 |.. .|  |...||   . .   | .|.|...| |  .. ..| | .|... . .||| ... |  ||| .|....    | . . | . .|.| ....
knrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgef

TIELDNIRKVRPATYSSVLKISEKgvESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTilrkqglekkifddSQRTPMTLVCFDGFSRSCTLVA
...|.. ..|        ||.  .  . ...|  . |  |   | |......|.|.........              |. .|. . |  |  |  |..|
evtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe..............sedaPlvvhCsaGvGrtGtiia

LDILCQRLTAshEIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYaIRHHLVNVE
.|.  . | |  |. .. .|. | ...||  | |.    ||.... ..|.|. ....| ..|
idyvrellka..ekipeeldvfdlvlelrkqraalvqtkeqyelvykavael.vqkeleiie
0037934 (Phosphotyrosine protein) phosphatases II 89-335 2.2e-28 94.9 In-house 12-241 (243) alignment 
Range on Protein: 89-335
Range on HMM: 12-241/243.0
ELNKFGEIQVYEQTRVRAvhrQGHNYLNSSWIDGYRetrKFIVAPSPMSESVAQ----FWRCVFDRNSLIVVTLCELL---DEKGKPFVPvkiGEPlVID
. | .  |  |...||.    .|..|.| ..|....   ..|.   |..|.|..    ||| ... .. ..|.|.||     ||  .. |   ||  ...
sknrysdilpydhsrvkl...egsdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tyg

DMTIELDNIRKVRPaTYSSVLKISEKG-VESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRkqglekKIFDDSQRTPMTLVCFDGFSRSCT
|.|..| ...         .|... ..  . ...|| . | .|   | |. |.|.||.| ...     |        .. ...  |. . |  | .|. |
dftvtllseehldd.ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell......sllaldsggpvlVHCsaGvgRtGt

LVALDILCQRLtasheigTpfVDILDTIARLRMLRGA-ACMKAEQFVFLSMSVLEY
|.|.......|       .  ||.......||. |.  |.   .|..|| . .||.
liaaylmllll.......g..vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 65-334 3.9e-28 93.3 In-house 25-277 (288) alignment 
Range on Protein: 65-334
Range on HMM: 25-277/288.0
KEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAVH---RQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCEL
.|.   ..|  ..  |.       . |.. .|  |...||.  .    .| .|.|.|.|||.....|.| . .|. ..| .||. |.....  .| | ||
eeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltel

L---DEKGKPFVPVKiGEPLVIDDMTIELDNIRKVRPATYSSVLKIseKGVeSHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILrkqglekki
.   ..| . . | . ..|    ..|..| . ...   .  ..|.   |   .. ..  . | .|   | |.   ..|.||  ..   .           
veggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkk.teleitqyqylaWpdhgvPeskapllellrqvkvanqad.........

fddsqRTPMTLVCFDGFSRSCTLVALDILCQRLTAsheigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
       |.. .| .|  |. | .||| | ... .     . ..|...|.|.||. |     . .|..|.   .|.
.....tgpiivhCsaGvGrtgtFialdalidavee.....edyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 89-345 4.4e-27 90.0 In-house 50-293 (319) alignment 
Range on Protein: 89-345
Range on HMM: 50-293/319.0
ELNKFGEIQVYEQTRVRAVHRQ---GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELlDEKGKPFVPVKI--GEPLVIDDM
. |.. .|  |..|||   . .   | .|.|.|.||||.| .||| . .|... .  ||| |....| ||| |..|  ||.| ..       .. .   .
kknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl.veklkvklkkywpeenfeeyGrl

TIELDNIRKVRPATYSS-VLKISEKGVEShKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifDDSQRTPMTLVCFDGFSRSCTLV
...|.. ..      .   |..    ||. ..|   .|  |   . |.|   .|||| .... |             . .|  |..  | .|  |  | .
ivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvPekatslldllkrirksr.............ektqsgPivvhCsaGvGRtGtfi

ALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHH-LVNVE
.||.  .|.          .|.  |. |||. |     . ||. |.   .||..   .  ..|.
vldamlervkeeg.....vlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievq
subfamily_PTPN23_pd Subfamily PTPN23 88-338 4.8e-27 89.5 In-house 44-282 (288) alignment 
Range on Protein: 88-338
Range on HMM: 44-282/288.0
PELNKFGEIQVYEQTRVRaVHRQGHNYLNSSWIDGYRE-TRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELlDEKGKP----FVPVKIGEPLVIDD
.| |.. .|  |...||  .. .  .|.| |.. .    . .||.. .|. .... ||. |... | ..| | .  .|.|||    . | . ||. . .|
seknrsrdilPyDhnRvk.lrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllsk.eelgkpkvdrYwPedkgetvkfgd

MTIELDNIRKVRPaTYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRKQGLEkkifddsqrtPMTLVCFDGFSRSCTLV
... | . |.  .     |||.. ....  |.| .| .  | .|| |. |...|..|  .... .  ...             |. . |  |  |. .. 
lsvtlksvretet.hvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt..........PlvvhCsaGvgRtgvfa

ALDILCQRLTASHEIGtpfvDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIR
 .    . |.. . .     ||.. . |||  |     . ||. |.   |||.| |
lvyaavrelekgngll....diiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 87-336 1.1e-25 85.3 In-house 41-276 (281) alignment 
Range on Protein: 87-336
Range on HMM: 41-276/281.0
HPELNKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPvKIGEPLVI
  . |..  |  |..|||.     . .  .|.|.....||.. ...|.. .|. .|...||. |....  ..| . . ...   |   . |    . | .
nvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselky

DDMTIELDNIRKvRPATYSSVLKISEKGVEShKTVILLTYSGWGKLGYPQKPSDILDLLADmnhmrtILRKQGLEKKifddsqrTPMTLVCFDGFSRSCT
 |.|..  . .. ..   . ..|..... |. ..|  |.|  |   | |......|.  ..      .|. .  ..|       .|. . |  |  |. |
gdvtvkstaeee.katyierkfkleresget.reveqlaytaWPdhGvPattkellefrke......vlkltekktk.......aplvihCsaGvGrtGt

LVALDILCQRLTASHEigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
 .||| |.....|..|     .|. ...| ||  |        |. |.   ||.. 
yialDrlvkaveaele....eldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 69-338 1.8e-25 84.5 In-house 10-270 (274) alignment 
Range on Protein: 69-338
Range on HMM: 10-270/274.0
HFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAVHR----QGHNYLNSSWIDGYRETRK-FIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD
.| .|||   .     | . . |.. .|   |..||   ..    .  .|.|. .| ||.|. | .. .  |... ||.||| .. ... ..| | .| .
eflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklke

E---KGKPFVPVKIGEPLVIDDMTIELDNIRKVRPATYSsVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilrkqgLEKKIFD
.   | . . | ...  .      .|. .  .|.   || | |.. | .|....|.   |. |     |.... .|||....            |..  .
aneqkCavyfPdaedyeiserygdveikvekiverndys.vrklvlkylerersvkhywytdWPdhksPddantlldlvlev...........eesreee

DSQRTPMTLVCFDGFSRSCTLVALDILCQRLTAsheigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIR
. ...|. . |  |  |    .| .| ...| .     . .||.| ... ||. ||    ..||. ..   . .|. |
naklapvvvhCsaGiGrtGcfiaisiavrqlre.....eivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_PTPRA_pd Subfamily PTPRA 69-337 2.8e-25 83.9 In-house 37-296 (330) alignment 
Range on Protein: 69-337
Range on HMM: 37-296/330.0
HFSSLPLSRLRTV---DAFFDHPELNKFGEIQVYEQTRVRAVHRQGH---NYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL
 | .|| ......    .  .  | |.. .|  |. .||   ...|.   .|.|.|.||||.|  ||| |  | .|.|  ||| .....|  .| | || 
efnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelk

D---EKGKPFVPVKigEPLVIDDMTIELDNIRKVRPATYSSVLKI--SEKG-VESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMrtilrkqglek
.   || . . | .    .   ....|...   .   |   .|    ...   .... |  . . .| ..| | .|  .|.||. ....           
erkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkl...........

kifDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
   .. .  |... |  |  |. |...|| . .|. | .      ||. ... |||. |       ||..|.   .||| .
...nqqsagpivvhcsaGvGrtGtfivldavlervkaerk.....vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 90-346 2.8e-25 84.4 In-house 28-266 (284) alignment 
Range on Protein: 90-346
Range on HMM: 28-266/284.0
LNKFGEIQVYEQTRVRAVHR---QGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCellDEKGKPFVPVKIGEplVIDDMTIE
 |..|.|  .....|.  .    .. .|.|.|.| ||.   |.| .  |. ...| ||| ... |.  .| |    ..|   . | || .    . . ..
knrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplkivi..keerfkvk

LDNIRKVRPATYSSvLKISEKGVESHK-TVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTilrkqglekKIfddSQRTPMTLVCFDGFSRSCTLVALD
.| . .    .  . ...||.| |  . ..    . || . | |. |||.. |.  ..|...         |     .|... . |  |  |. . ..||
vdsveeseeyvvrd.ielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhlts.........ke...nhranivvhcsagvgrtgvyivld

ILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE-YAIRHHLVNVED
.| .|.   .      ||. ...  ||  |     .  |. |. ...|| . . |  | . |
vlldrmkeek.....qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpd
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 90-346 3.1e-25 84.1 In-house 64-302 (319) alignment 
Range on Protein: 90-346
Range on HMM: 64-302/319.0
LNKFGEIQVYEQTRVRAVHR---QGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCellDEKGKPFVPVKIGEplVIDDMTIE
 |....|  .....|.  .    .. .|.|.|...||.   |.| |  |. ...| ||| ... |.  .| |     .|   . | || .    . . ..
knriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplkivi..keerfkvk

LDNIRKVRPATYSSvLKISEKGVESHK-TVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTilrkqglekKIfddSQRTPMTLVCFDGFSRSCTLVALD
.| . .    .  . ...||.| |  .  .    . || . | |. |||.. |.  ..|...         |     .|... . |  |  |. . ..||
vdsveetaeyvvrd.ielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlts.........ke...nhranivvhcsaGvGrtGvyivld

ILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE-YAIRHHLVNVED
.| .|.   .      ||. ...  ||  |     .  |. |. ...|| . . |  | . |
vlldrmkeek.....qvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 89-336 3.2e-25 83.8 In-house 11-242 (250) alignment 
Range on Protein: 89-336
Range on HMM: 11-242/250.0
ELNKFGEIQVYEQTRVRAVHRQ---GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELlDEKGK---PFVPVKigEPLVIDD
| |.. .|  ....||   . .     .|.|.|...||.|.. ||.. .|..... .||| |....|  .| | .|  |..|    . ||.  ..    |
eknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnL.kesektyhqywPve..kaekyGd

MTIELDNIRKVrPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifDDSQRTPMTLVCFDGFSRSCTLV
.|..| .  .      . .||.|..  .....|  | .  |   | |..   .|.|| ...  .             . .. .|. . |  | .|| . .
vtvsllskeef.adytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasq.............qqagnaPvivqCsaGvgrsGafi

ALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
|.| . .||  ..      ||. . | .||  |  |    ||.||. . .|.. 
aidavlerlkkekv.....vdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_PTPRK_pd Subfamily PTPRK 89-335 2e-23 77.7 In-house 45-276 (314) alignment 
Range on Protein: 89-335
Range on HMM: 45-276/314.0
ELNKFGEIQVYEQTRVRAVHRQGH---NYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGKPFVPVKIGEPLVIDDMTI
| |..|.|  |...||. .  .|    .|.|...||.|. ...|||.  |. | |. ||| |.| |.  .| | || ..   . .     .  | .|. .
eknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikv

ELDNIRKVrPATYSSVLKISE--KGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTIlrkqglekkifddsQRTPMTLVCFDGFSRSCTLVA
|| .         . ......  .|.| ...|  . . || . . |..   .|.|.. .....                .  .. . |  |  |. | .|
elvetell.aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee..............eaGrivvhCsaGaGrtGtfia

LDILCQRLTAsHEIgtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
.||... .   ...    ||.  ..  ||  .       ||..|.   .|| 
idivldmier.egv....vdvfnavktlrsrkvnmveteeqykfiydvilea
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 89-336 2.6e-23 77.4 In-house 49-278 (287) alignment 
Range on Protein: 89-336
Range on HMM: 49-278/287.0
ELNKFGEIQVYEQTRVRaVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEK-GKPFVPVKIGEPLVIDDMTIEL
..|.. .| |... ||  .. . ..|.|...||||.| ..||.| |||.. . .||. . |||  ..| ||.. ...  . .     .. .|. . .|||
dknRltqilvpdnyrvl.lkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniel

DNIRkVRPATYSSVLKISEKG-VESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilRKQGlekkifddsqRTPMTLVCFDGFSRSCTLVALDI
 |   |        |.. .|.  .....|    .  | . |  ..|  || .. .|.. .   ||.|          .|..   | |.  || ...| ..
lnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq...rkrg..........ntsivvhCsdtvGrsamfcaaat

LCQRltASHEiGTpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
  ..  .  | |.  .|... . . |. .  .   .||. |.   |||| 
tink..ckte.Gv..iDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 84-338 3.3e-22 73.8 In-house 17-266 (270) alignment 
Range on Protein: 84-338
Range on HMM: 17-266/270.0
FFDHPELNKFGEIQVYEQTRVRAVHRQ---GHNYLNSSWIDGYRE-TRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL---DEKGKPFVPVKIGE
.  ...||.. .|    .||||  . .     .|.|  .. |. . ..|.| | .|.  .. .||| ......  .| . .|     .| . . | . .|
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

PLVIDDMTIELDNIRKVRPATYS-SVLKISEKGvESHKTViLLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRkqglEKKIFddSQRTPMTLVCFDGF
 . . |..|.  .. ...   |    |.. ||| |... |    |  |   | |... . |.    .. .|.. |     .| .  .. .|.   | .| 
kvkledgkikvlalseekeegyiltrlrleekg.eerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrr....sekel..dkaePllvHcsaGv

SRSCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIR
 |. ||.|||| .. |  ...     ||.|  |..||  | |   . ||. ||  .|.||| |
gRtGtlialDiavrlLeetkk.....vdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_PTPRG_pd Subfamily PTPRG 91-335 5e-22 72.8 In-house 51-286 (563) alignment 
Range on Protein: 91-335
Range on HMM: 51-286/563.0
NKFGEIQVYEQTRVRAVHRQG----HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVkiGEPLVIDDM
|.  .|  |...||.     |    ..|.| ..||||. ...||..  |. . .  ||| ....|. |.|.. .| .   .| . . |    |.. .. .
nRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygal

TIELDNIRKVRPATYSsVLKISE-----KGV-ESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilrkqglekKIFDDSQRTPMTLVCFDGFSR
.. | .  ..   |    |.| .     |   ...|.|.   |. |   | |...   |                    .    ..  |..  |  | .|
qvtlieeevlalytvr.tlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks..............saankaeaGPivvHcsaGvgr

SCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
. |...|| | ... . .      |...... ..|. |     . ||..||   .|| 
tGtyivldtllkqiqqena.....vnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 90-337 5.1e-22 73.4 In-house 51-289 (325) alignment 
Range on Protein: 90-337
Range on HMM: 51-289/325.0
LNKFGEIQVYEQTRVRAVHR--QGH-NYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCEL--LDEKGKPFVPVKIGEPLVIDDMT
 |.| ..  ....||  . .  ... .|.|.|..  ...   |. | .|.....  .|| |.| .. .|| | ||   ...   . | ..|.      . 
knrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGgle

IELDNIRKVrPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRKQglekkifdDSQRTPMTLVCFDGFSRSCTLVAL
..|  | ..       ||.. .      ..|  . . .|  .| ...|. .. .|  ....   .. .            ||. . | .|  |. ....|
vklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtan........tkastpilvhcsaGvGrtGvfisl

DILCQRLtasheIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
  . ...     |    |||.. . .||  | .    ..|....  .. |. .
ysalakv.....ieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_PTPN1_pd Subfamily PTPN1 88-336 7.2e-22 72.4 In-house 33-271 (290) alignment 
Range on Protein: 88-336
Range on HMM: 33-271/290.0
PELNKFGEIQVYEQTRVRaVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVKIG-EPLVIDDM
 .||.. ... |. .|.. ..|.  .|.|.| ..  .  |..|..  |... |. ||. |....|  || | .....   |   . | .   . |...|.
rnlnryrdvspydhsrik.leradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledt

TIELDNIRKVRPATYS-SVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilRKQGLEKkifddSQRTPMTLVCFDGFSRSCTLV
..... |.. |  .|  ..|.. ..  .  ....   |  |  .| |. |.  |..| ..       |. |  .     |.  |  . |  |  || |..
klkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkv.......resGsls.....sdvGpavihcsaGiGrsGtfc

ALDILCQRLTASHEIGTpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
 .| .  .. ..... .  ||| ...  ||  |      |.|. | ....|| |
lvdtclvliekkddlss..vdikkvllelrkyrlGliqtadqlrfsylaileGa
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 80-336 3.3e-21 70.4 In-house 39-283 (290) alignment 
Range on Protein: 80-336
Range on HMM: 39-283/290.0
TVDAFFDHPELNKFGEIQVYEQTRVRAVHRQGH-----NYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKG---KPFVP
||.   .  .||.| .| ||.. |.   . .||     .|.| ..|.||.| ...|.. .|.|. ...||. . .... |.| |..  .|.    . . |
tvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp

VKiGEPLvIDDMTIELDNIRKVRpATYSSVLKISEKGV-ESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNhmrTILRKQGleKkifddsqrTPMTLV
 . .    .. ..|.| | ...        |.. .|   .....|. .  . | . |  ..|. || ... |.    . ||.|  .        |.. . 
ds.dtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy...ktqrkrg..n........tsivvH

CFDGFSRSCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
| |. .|| ...|...  ..           .|... . ..|. .      ..|. ..   ||.| 
CSdtvgrsavfcaaattinkcktegv.....idvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_PTPN3_pd Subfamily PTPN3 91-334 3.9e-21 70.2 In-house 45-273 (280) alignment 
Range on Protein: 91-334
Range on HMM: 45-273/280.0
NKFGEIQVYEQTRVRAVHRQGhNYLNSSWI----DGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVkIGEPLVIDDM
|.. .|  |..|||. .. .  .|.|....    ..     ..|..  |.......||. |....| ..| | .|...   | . . |   .. |   ..
nryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygef

TIELDNIrKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifdDSQRTPMTLVCFDGFSRSCTLVA
.... .  . . .     | ...|  . ..... | |  |   | |....|.|...  ....|               ....|. . |  |  |.  |..
svkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr..............sgkeePvvvhCsaGigrtGvlil

LDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
|..  . . |...     | .|| . ..|  |..    |.|. |.  ..|.
letalalieaaep.....vypldivrtmrdqramlvqtasqykfvCeailk
0041856 (Phosphotyrosine protein) phosphatases II 89-337 5.8e-21 70.3 In-house 3-172 (182) alignment 
Range on Protein: 89-337
Range on HMM: 3-172/182.0
ELNKFGEIQVYEQTRvravhrqGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCelldekG------KPfvpvkigeplvidd
..|.. .|  |...|       . .| | ....|.. ...||..  |. ..||.|.| . ...  ..|.|.      .      .               
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpell..............

mtieldnirkvrpatyssvlkisekgvesHKTVILLTYSGWGKLGYPQkPSDILDLLADMNHmrtilrkqglekkifddsQRTPMTLVCFDGFSRSCTLV
                             ....| . | .|   | |  ....||.. ....                  .  |    |  | .|..|||
.............................erlgiqylylpwpDhgvpd.ldelldfieevle..................eggpvlVHCsaGvgRtgtlv

ALDILCQRltasheigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
|.......           |.. .... .|. |  ..   .|..|| . .||.  
aaylmkkl..........gvsleeavklvrsrRpgmvitpnqyfflqlallelll
PTPc_DSPc_SM00012 215-333 1.1e-20 69.2 In-house 2-104 (105) alignment 
Range on Protein: 215-333
Range on HMM: 2-104/105.0
VILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRKqglekkifddsqRTPMTLVCFDGFSRSCTLVALDILCQRLTASHeigtPFVDILDTIARLRML
|  . |.|| . | |.....||.||..... ..   .            ..|. ..|..| .|..|.||||||.|.|....     .|||.... .||. 
vkhyhytgwpdhgvPeesdsilellravkknknkses............skpvvVhCsaGvgRtgtfvaldillqqleket....kevdifqivkelrkq

RGAACMKAEQFVFLSMSVL
|  ..   ||..|| . .|
Rpgmvqteeqylflyrall
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 89-335 2.2e-20 67.8 In-house 51-278 (315) alignment 
Range on Protein: 89-335
Range on HMM: 51-278/315.0
ELNKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGKP---FVPVKigePLVIDD
. |.. .|  |...||.       .. .|.|...||||   |..| | .|  .||  ||| ||. .   .| | .| ... .    . | |    ..   
qknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGk

MTIELDNIRKVrpaTYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDIldlladMNHMRTIlrkqglekKIFDDSQRTPMTLVCFDGFSRSCTLV
.|. . .  .    |  .|  .|    .  ..|. | |. | . | |.    .      || .||.        | ..... ... . | .|  |. |..
itvtrkseevn...teytvrtlsvvfgdnirevvqlhytswpdmgvpkytipl......mnlirtv........kqhhtnsvgaivvhcsaGvGrtGtfi

ALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
.|| . ... | .      .|. . | ..|  |  .   |||. |.   .|| 
tldavldqaeaen.....aidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_PTPN6_pd Subfamily PTPN6 90-336 3.1e-20 67.4 In-house 57-297 (306) alignment 
Range on Protein: 90-336
Range on HMM: 57-297/306.0
LNKFGEIQVYEQTRVRA--VHRQGHNYLNSSWIDGYRE--TRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLvIDD
 |..  |  ...|||     . .|..|.|.. |..  .  ....| .   ... |..||| |.. || ..| . . ..   ||  .. | .  ..    .
knryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGk

MTIelDNIRKVRPATYS-SVLKIS-EKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTILRkqgleKKifddsQRTPMTLVCFDGFSRSCT
...   |... . |.|    |..| .|  .....|. . .  |   | |..|. .||.| |.|. .  |.     ..     .  |.   | .|  |  |
isv..tnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeele.....ea.....eagpivvhCsaGiGRtGt

LVALDILCQRLTaSHEIGTPfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
.. .||| . .. .. . .. .|| ...  .|  |      ..|. |. ... .| 
fiviDillklie.kkgldad.idiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_PTPN14_pd Subfamily PTPN14 58-335 4e-20 67.0 In-house 20-295 (300) alignment 
Range on Protein: 58-335
Range on HMM: 20-295/300.0
LSTSSVGKEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAV--HRQGHNYLNSSWIDGY--RETRKFIVAPSPMSESVAQFWRCVFDRNSL
|. . | .|. . .   .  | .. .  .  | |.| ..  ||..||. .  . . ..|.|.| |      ..|..||| .|.   | .||..|.. .  
leegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

IVVTLCELL---DEKGKPFVPVK--IGEPLVIDDMTIElDNIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTI
..| | |      ||   ..| .    . .  .   .   . ..  ...  . ||.     . ..||. | |  | . | |. ... |. | ... .|  
livmlteeeedgkeksfkyfPkleskkktvefgkfkvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

LrkqglEKKIFDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEIgtpfvDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
      ....   ... |. . | .|  |.  |.  |.| . |   .||     ||  ..||||  |        |. |.   ...|
t.....nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneei.....dikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 86-336 1.5e-19 65.1 In-house 32-259 (267) alignment 
Range on Protein: 86-336
Range on HMM: 32-259/267.0
DHPELNKFGEIQVYEQTRVRaVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGKPFVPVKIGEPLVIDDMTI
.  | |.. .   |..|||  .  . ..|.|.|...||.  ..|||   |.. ....|.  . |..  ..| |     .. . | | |.|.    .|.|.
knqernrlddnlpyddtrvi.lrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdltv

ELdNIRKVRPATYSSVLKISEKgVESHKTVILLTYSGWGkLGYPQKPSdildlladMNHMRTILRKQGLEKkifddsQRTPMTLVCFDGFSRSCTLVALD
|  .. |        .|..  |  || . | |  |  |  .   .||         .. .  || |. ||.         |. . | ||  || |.. .|
eh.slekeendyqiitlelkfk.nesahnvtlyyykkwn.intnnkpy........lkplfgilaknqlen......gnrPlvvacsdGvGrsGtflvid

ILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
   .|.          .|| | . ..|  | .     |.....  .. |||
sqlerakteg.....vsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_CG7180_pd Subfamily CG7180 110-337 2.1e-19 64.3 In-house 68-291 (296) alignment 
Range on Protein: 110-337
Range on HMM: 68-291/296.0
QGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKG--KPFVPVKIGE---PLVIDDMTI-ELDNIRKVRPATYSSVL-
.  .|.|....|..   ...||   |. |.| .||| |.|...  || |..  | .   . ..| |  |   ..... ..  .. |...     .  .. 
eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkiva

-KISEKGVE-SHKTVILLTYSGWGK-LGYPQKPSDILDLladMNHMRTILRKQglekkiFDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEigt
    ||.|.   ..| |. .  |      |   . ...|   .. .|.. .|        .| .. |.  |. || |||   .|.|.  . .   .|   
lteqekqvkaetRivklfqlteWeledkvPlstnaliel...rrrvrlwrekv......dedpeegPvvvvssdGasRsGvylaidanlelvekeee...

pfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
  ||. . . .||  |     . |.. ..   .||. .
..vdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 86-337 1e-18 62.1 In-house 48-280 (439) alignment 
Range on Protein: 86-337
Range on HMM: 48-280/439.0
DHPElNKFGEIQVYEQTRVRAVHRQG---HNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGkpFVPVK----IGEPL
|..  |.. ..  .. |||      |     |.|. .|.|| . . .| .. |  |.. .||| |.....  .|.|..|..     . | .     |.  
dqtk.nrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsdaevcygdia

VIDDMTIELDNIrKVRPatYsSVLKISEKgVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifDDSQRTPMTLVCFDGFSRS
|  |  ||| |   .|   .  |..  ..  |  .||. . |  | .   | . | .||.|  .|                |. .  |. . |  |  |.
vrvdrnielpny.virg..f.kvfnerdt.tekertvlqfhyiawpdknvpaqashvldflrainsan.............dkeeygpvvvhcsagvGrt

CTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
 |..||||  ..| .  .     |||   .  ||  |     .  |.||.  .|||  .
Gtiialdialeqlklenk.....vdikgivkvlrkqrkqmvqalcqyvfiynavlediv
subfamily_PTPN13_pd Subfamily PTPN13 86-334 1.1e-18 62.5 In-house 36-267 (273) alignment 
Range on Protein: 86-334
Range on HMM: 36-267/273.0
DHPELNKFGEIQVYEQTRVRAVHRQGhnYLNSSWIDG--YRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCE-LLD--EKGKPFVPVKIGEPLVI
.. . |.. ..  |..|||.     |  |.|.|.|      .. ..|..  |. |.|. ||. |..... ... .     .   | . . |.. ...|..
enkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkv

DD-MTIELDNIRKVRPATYSSvLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifdDsQRTPMTLVCFDGFSRSC
 . ...|| .. |    . .. |.....  .  . |  | .  |   | |... ..| ..| .....              . ...|.   |  |  || 
snrlevellkvqkldgfvvra.lavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlq..............t.dagPivvhcsaGiGrsG

TLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
||...|.. . .   .      .|. ... .||  | .     .|..|   ..||
tlitidvvlglierdk.....efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 90-335 2e-18 61.2 In-house 41-276 (287) alignment 
Range on Protein: 90-335
Range on HMM: 41-276/287.0
LNKFGEIQVYEQTRVRAVH--RQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTL-CELLDEKGK--PFVPVKiGEPLVIDDMT
 |.....  ...|||  ..  ..| .|.|. .. .|..  .||.| .|.. .| .||| |....|  |.|.  |. . . |   . | .   |. .   .
knryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGys

IELDNIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPsdildlladMNHMRTILR-KQGLEKKiFDDSQRTPMTLVCFDGFSRSCTLVA
. | .  .  |      |.. .   .  . |  | .  | . . .            .  .| .|  || .| .  | |.  |. . .  |  || .|.|
vvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPta.........vglirfvldvkqhiela.rdasevGPlvvhddvGiGrsGilla

LDILCQRLTashEIGTpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEY
. .| .||    ..|   ||.  ...|||. | |    . |. .|  ..  |
tlvlvsrle...dlGr..vdvaavvirlreyraalvqavvqlrllyealvty
0043147 (Phosphotyrosine protein) phosphatases II 111-328 2.2e-18 62.0 In-house 4-153 (172) alignment 
Range on Protein: 111-328
Range on HMM: 4-153/172.0
GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELldekgkpfvpvkigeplviddmtieldnirkvrpatyssvlkiSEKGVE
|..| | |..|.|. ...||.   |... .|.||| . ...  ..|.|.||                                              .  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpel

SHKTVILLTYSGWGKLGYPqKPSDILDLLADMNHMRTILRkqglekkifddsqRTPMTLVCFDGFSRSCTLVALDILCQRLtasheigtpfvDILDTIAR
 ....| . | .|   | |  .. .|..|  ....  . .               |.   |  |..|..||||.......|           ......| 
lerlgiqylylpwpDhgvp.llellleflefidellalsp.............ggpvlVHCsaGvgRtgtlvaaylmllgl...........sleeaval

LRMLRGAACMKAEQFVFL
.|. |. |.   .|  ||
vrekRpgavqnpsqyrfl
0049772 (Phosphotyrosine protein) phosphatases II 75-339 2.1e-17 59.3 In-house 34-277 (314) alignment 
Range on Protein: 75-339
Range on HMM: 34-277/314.0
LSRLRTVDAFFDHPELNKFGEIQVYEqTRVRA--VHRQGHNYLNSSWIDGYretRKFIVAPSPMSESVAQF----------WRCVF--DRNSLIVVT---
 .  ..|  .| ... | . .|. .. .||..  .. .|..| |.|..||.   .|||..  |... |  |          || |.  |.|. ..|    
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------LCELLDEKgkpfvpvkigeplviddmtI----------EldnirkvrpatyssvlkiSEK--GVESHKTVILLTYSGWGKlG
                  |..|                                  .                  .|   .    ...| . .  .   |
evladelsrLdaAlgKtpllildgng...................neptaadlellk..................eelydpelferlgikylripvpD.g

YPQKPSDILDLLADMNHMrTilrkqglekkifddsQRTPMTLVCFDGFSRSCTLVALDILCQRLTasheigtpfVDILDTIARLRMLRGaACMKAEQFVF
 .  ..|....|. ..                   . .|    | .| .|..|.|....|. .|          |.. ......|. |  ....  .. .
saplledfdeflefieea.d...............kggpvlvHCkaGkgRtgtfvvaaylmkllg.........vsleealedvrlkRp.inpnpgfieq

LSMSVLEYAIRH
|   . .. ...
leqyefileall
0036282 (Phosphotyrosine protein) phosphatases II 111-328 7e-17 57.1 In-house 1-162 (174) alignment 
Range on Protein: 111-328
Range on HMM: 1-162/174.0
GHNYLNSSWIDGYRETRKFIVAPSPMSesvaqFWRCVFDRNSLIVVTLCELLDEK---------Gkpfvpvkigeplviddmtieldnirkvrpatyssv
|..|.| |..|... |...|.   |..     ||. ... .. .||.|.|.   .                                             
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

lkiseKGVESHKTVILLTYSGWGKLGYPQKPSdILDLLADMNHMRtilrkqglekkifDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTasheigTPF
     .    ....| . | .|   | |  .  .|...  ... .              ...  |.   |  |..|. ||||.......|       ...
.....lredlerlgiqylylpwpDhgvpdlsi.llefvkfveeal.............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll......esl

VDILDTIARLRMLRGAACMKAEQFVFL
||.||....||. |. ..   .|. ||
vdaldlvrelRlqrpgmvqtpsQyrfl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 81-343 7.1e-17 56.3 In-house 29-277 (285) alignment 
Range on Protein: 81-343
Range on HMM: 29-277/285.0
VDAFFDHPELNKFGEIQVYEQTRVrAVHRQGHNYLNSSWIDG-YRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGE
  |.   |.||.. .... |.|||  .. . ..|. .||.    ..   .| .  |. |....||. ... .   |. || |..   ||   . | |.||
ytayeanpdlnryadvrcieetrv.vlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

PLVIDDMTIELDNIRKVRPA-TYSSVLKISE-KGVESHKtVilltYSGwgKLGYPQKPsdilDLLADmNHMRTILRKQGLEKKIfdDSQRTPMTLVCFDG
 . .    | | . ..   | |    | . . .   |   .    |    ..  |  |    | ||  .  | ..      ||.  . . .|. . |  |
vvkfgkyeitlteckeeaiagtilnaltvintedassep.l....ymn..hvqvpwwp....dqlap.edarpmielykwvkkv..npkekpicvhcsag

FSRSCTLVALDILCQRLtasheIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHHLVN
  |..|.| .|    |.     .  | ...|| .  .| .|  |     ||.|| . ..|| |   .|.
vgrtatfvgidyatiri.....menpniemldivremramrfqavqshmqflflyvvlmeyfigegvve
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 62-346 1.1e-16 55.7 In-house 20-282 (288) alignment 
Range on Protein: 62-346
Range on HMM: 20-282/288.0
SVGKEFSHfsSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAVhRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCEL
.. ||.    |   .  ...|.| . |  ... ..   . |||.      . | ..  .   .  |..| | .|.   . ..|. ... .   .| ||||
glkkeyrd..spneasidiidsfianptrdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcel

LdEKG----KPFVPVKIGEPLVIDDM-TIELDNIRKVRPATYSSVLKISEKGvESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilrkqglek
| |||    . . |.|.||   |  . |.  ..   .      |.|.||..| | .. |  | .  | . | |..    | ||  .              
l.ekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsllriskeg.eekvivkilhlleWdddgvPenylsplrllevl..............

kifdDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHH-LVNVED
     | . |. . .  |  |. ||.   |  . |  .      |. |   .|.||  |  |     |....   |||. . ..  |. ||
....kslqkPivvhssaGvGrtgtlililialeslrldd.....flgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlred
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 64-344 2.7e-16 54.3 In-house 22-286 (315) alignment 
Range on Protein: 64-344
Range on HMM: 22-286/315.0
GKEFSHFSSLPLSRLRTvDAFFDHPELNKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCE
 .||  .   . .| |.     .  . |....|  ....||.         ..|.|.| | .. . . .| .  |   ||  ||| |.. .   .| . .
seefhdlpdPdiyrqrv.aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

LLDE---KGKPFVPVKIGEPLVIDDMTIELDNIrkvRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilrkqglekK
. ..   | . . | . ..      . .|| ..    . |   . |.  .  |...||    . .| . | ... | .| |. ..              |
kqegdkikcrqywPdrkadsvefGsikvellsl...eadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikev..............k

IFDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTAsheigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI-RHHLVNV
  ....  .. . |  |  |.  ....|   ...       |  ||.....  ||  |       |.. |.  .|||.   |  |. |
adngkkefsllvhcsaGvGrtGvvisidevvaqikr.....trsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 80-337 2.2e-15 51.3 In-house 26-267 (283) alignment 
Range on Protein: 80-337
Range on HMM: 26-267/283.0
TVDAFFDHPELNKFGEIQVYEQTRVRaVHRQGHNYLNSSWID---GYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL---DEKGKPFVPVK
....  .... |.. || ...| ||. .. . ..|.|...|     |.. .|.|.| ||. . |  ||. |||..   .| | .|    ..|   . | .
diasadenkrknrnqeivpadqwrve.lksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr

IGEPlvIDDMTIELDNIRKVRpATYSSVLKISEKgvESHKTVILLT-Y--SGWgkLGYpqKPSDILDLLADMNHMRTILRKqglekkifddSQRTPMTLV
  |     ..|. | .    . .     | .  .   | |. .||. |   .|  | |   .  |.. |  .| ...  ..          |...|. . 
Gsed..yGeftvtlrkettsn.sfiikelllrvn..ssakstlllahyqvidW..ley..geqaiinslvkfnkvislqte..........skkgPivvh

CFDGFSRSCTLVALDILCQRLTASHeigtpFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
|  |  |. ...|.    . . ..       ||.  ..  .|  |  |  . .|. ..   ||| |.
CstgiGrtavfiaasasvkdaltes.....vvdvfavvkimreqrmmavqtldqyklvhelvleqal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 88-164 9.4e-15 49.1 In-house 41-122 (301) alignment 
Range on Protein: 88-164
Range on HMM: 41-122/301.0
PELNKFGEIQVYEQTRVRA-----VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE
 .||.| .|.||.. |.       .. . ..|.|.|.||||.|..|||.| .|| . ...||| ...     .|....| ..
kalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkeg
subfamily_PTPRN_pd Subfamily PTPRN 90-334 2.3e-14 47.8 In-house 59-290 (297) alignment 
Range on Protein: 90-334
Range on HMM: 59-290/297.0
LNKFGEIQVYEQTRVRAVHR---QGHNYLNSSWID-GYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDD
 |.  ..  |...||.  ..   . ..|.|.| |      .  .| . .|....||.||. |... . ..|.|..| .   .. | . | .  |   | .
knrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiye

MTIELDNIRKVRPATYSSVLKISEKgvESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNhmrtilrkqglekKIFDDsQRTPMTLVCFDGFSRSCTLV
. .  . |        |  ||  ..  .  .||  . .  | . | | ..  .|..   .|             | .   . .|. . |.||  |. . .
vhlvsehiwcddylvrsfylknlqt..setrtvtqfhflswpeegvPasaksllefrrkvn.............ksyrG.rscpivvhcsdGaGrtGvyi

ALDILCQRLTAsheiGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
..|....||.     |   .||  |.  ||  |       .|| |  ..| |
lidlvlnrllk....Gvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 89-337 3.1e-14 47.8 In-house 53-285 (297) alignment 
Range on Protein: 89-337
Range on HMM: 53-285/297.0
ELNKFGEIQVYEQTRVRAVHRQGH---NYLNSSWIDGYREtrKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL--DEKGKPFVPVKIGEPlvIDDM
| ...  |  |.. ||.   .. .   .|.|.|.. |...  ..|    || ..|| ||. |.| .  ..| | ..   |.| . . . |   .    |.
eksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt..fGdv

TIELDNIRKVRPAtYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSdILDLLADMNHMrtilrkqgleKKIFDDSQRTPMTLVCFDGFSRSCTLVA
...|  . . .       |....    ... |    .  | .   ..| | .  ||  .. .          .| |.. . .|. . |  |  |   |..
svvllsvsereGf.ikrelevtkgkakarrvvkqyqfveWPdkaverkds.assllklisev..........rkdfsqnaegPllvhclaGvGrtgvllt

LDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI
.|    .    .|     |||.... .||  |       ||. |.   |||. .
idsvvaeakreke.....vdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 88-338 6.7e-14 46.1 In-house 46-239 (392) alignment 
Range on Protein: 88-338
Range on HMM: 46-239/392.0
PELNKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKgkpfvpvkigeplviddmt
 . |....|  |...||.         ..|||.|.|...   . .| . .| . |. .||| ||. |   .. . .| .                     
lkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...................

ieldnirkvrpatyssvlkiseKGvESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHmrtilrKQGlekkifddSQRTPMTLVCFDGFSRSCTLVAL
                      || ....||    .. |   . |.. | .| .. ...       . |        .   |. . |  |  |.  ....
......................kg.ddartvaqfhftewPdkdvpkhtssllkfikevka......dfG........qythpliihcsagvgrtgvvisi

DILCqrltaSHEIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI-R
| .      .|   | .||... .. .|  |       ||. |.  .|||  . |
dsvv.....ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwr
0051429 (Phosphotyrosine protein) phosphatases II 112-345 1.1e-13 46.9 In-house 4-234 (272) alignment 
Range on Protein: 112-345
Range on HMM: 4-234/272.0
HNYLNSSWIDGYRE---TRKFIVAPSPMSESVAQFWRCvFDRNSLIVVTLCELLDEKGKPFVPVK--------------IGEPLVIDDMTIELDNIRKVR
 .| | ....||      .... .. |.  ..|.|||   . .   .|.|...   .  .. ..                 ..|... . . |  . .  
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

PATYSSVLKISEkGVESHKTVILLTYSGWGKLGYPQKPsdILDLLADMNHmrtilrkqglekkifddsqRTPMTLVCFDGFSRSCTLVALDILCQRLTAS
   .  .|..   . .   .| .|.| .|   |.||..  .|.||. ...                     |.   |. | .|. |.|||..| ......
yilrellltlll.sagearevmhlhytdwpdhgvpqea..llellellld...................ggpvlvHCsaGkdRTGtvvallllllgvsle

heigtPFVD--------ILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHHLVNVE
       ||        .......||  | .|    ||..|| . .||.. ..  |..|
.....tivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvrae
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 91-344 1.6e-13 44.6 In-house 47-285 (515) alignment 
Range on Protein: 91-344
Range on HMM: 47-285/515.0
NKFGEIQVYEQTRVRA--V-HRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVKIGEPLVIDDMT
|....|  |...||.   .     ..|.|.| | ..   . .| .  |   ||  ||| |.. |   .. . .| ..   |   . | | |. .    . 
nryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsik

IELDNIRKVRPATYSSvLKISeKGVEsHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrtilrkqglekKIFDDSQRTPMTLVCFDGFSRSCTLVAL
.||  .     ..    |..  || .  .||    . .| . | |.. | .| |. ..              |   .    |. . |  |  |   ....
velvsleactggikrk.ltvl.kgdd.srtvtqfhfteWPdkGvpkhtssllklikev..............kadhgqythpliihcsaGvGrtGvvisi

DILCqrltaSHEIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAI-RHHLVNV
|        .|   |  ||.....  .|  |       ||. |.   |||.   |  |. |
dsvv.....ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipv
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 89-338 2.7e-13 44.2 In-house 58-285 (290) alignment 
Range on Protein: 89-338
Range on HMM: 58-285/290.0
ELNKFGEIQVYEQTRVRAVHRQGHNYLNSSWIDGYREtrKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVKIGEPLVIDDMTI
. |.. ..   ..|||     .  .|. . ...| .    ||..  .. ..| ..|| | . .   .| ||||...   | ... | | || | . ..|.
kknrykdvvcndktrvilkdGydGdyvhanyvkGlka..mfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitv

ELDNIRKVRPATYSSVLKISEkgVESHKTVILLTYSgwgKLGYPQKPSDildlLADMNHMRT--ILRKQglekkifddsqRTPMTLVCFDGFSRSCTLVA
   .  .    .   .| . .  ..| |  .|  .       .|.|       |...  .||  ||||              |... |  |  |. |.||
lcseeddkdaniikktlsvrd..kdsGkehklkhlk...ikswpdksva....lstlallrtlrilrka...........sGpvvvhcsaGiGrtGtfva

LDILCQRLTASHEIgtpfvDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIR
...  | |.  .|.     |.||..  ||  | ..     |.. |   .|..   
ievglqilldGkel.....dlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 64-338 6.1e-13 43.1 In-house 14-271 (281) alignment 
Range on Protein: 64-338
Range on HMM: 14-271/281.0
GKEFSHFSSLPLSRLRTVDAFFDHPELNKFGEIQVYEQTRVRAV----HRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLC
 .||| .   | | | ||       . |.. .| . . .||.       ..  .|. . .|      | .|..  |  |. |.||| ... |.  .| ||
kqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlc

ELLD---EKGKPFVPVKIGEPLVIDDMTIELDNIrKVRPATYSSVLKISEKGVEShktviLLTYSGWGKLGYPQKPSdildllaDMNHMRTILRKqglek
..|.   ||   ..| .    | .| .... ..   |  .  .. |..| .|        |.|.  | .    | |          . |  ||||     
qfletnrekcaeyfprnahcclqfdklsvsyeds.tvnkslvttrlnlsyegetr.....lithwlwkewpdwqvpe.......ssevmlkilrk.....

kIfdDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEigtpFVDILDTIARLRMLRGAACMKAE-QFVFLSMSVLEYAIR
 |   .. ||  . |  |  || ||.|..|  | . .       . || . ...||.   || ...  |....   .|.. . 
.i..rarstppvihcsagvgrsgtlmaveialqsihshft....lpdikqivshlrvtgraasvqtlqqymliwkvlldfgva
0049260 (Phosphotyrosine protein) phosphatases II 119-328 1.5e-12 42.9 In-house 1-142 (152) alignment 
Range on Protein: 119-328
Range on HMM: 1-142/152.0
WIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDeKGKPFVPVKIgeplviddmtieldnirkvrpatyssvlkisekgveshktviLL
.||||.  ..|| .  |.....|.||| . . .  ..|.|.|||. .||....  |                                            
fidgyampfefiatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyi..........................................qy

TYSGWGKLGYPQKPSDILDLLADMNHMrtILRKQGlekkifddsqrtPMTLVCFDGFSRSCTLVALDILCqrltasheigtPFVDILDTIARLRMLRGAA
 .  |   | |. .  .|.||  ....  .|.|.|            |    |. |..|. ||||.....             |......|..|. |  |
lhlpwpDhgvpdlsqlllflllfiekl..aldkgg............pvlVHCsaGvgRtgtlvaaylml...........lgvsleeavalvrekRpga

CMKAEQFVFL
.   .|  ||
vpnpgqlrfl
0046846 (Phosphotyrosine protein) phosphatases II 108-335 2.3e-12 42.5 In-house 8-172 (176) alignment 
Range on Protein: 108-335
Range on HMM: 8-172/176.0
HRQGHNYLNSSWIDGYRetrkFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL-------DEKGKPFVPVKIgeplviddmtieldnirkvrpatyss
.. . .|.| ..|.|.|    .|.   |. ...|.|.. ... .  .||.|.|.        .   . .  ..|                          
ldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

vlkisekgveshktviLLTYSGWGKLGYPQKpSDILDLLADMNHMRtilrkqglekkifddSQRTPMTLVCFDGFSRSCTLVALDILCQrltasheigTP
                   . .|   | |.  ...|.||. .. ..               ..  |    |. | .|..||||...|.            
................qylhlpwpDhgvpdl.elllellefireal...............keggpvlVHCsaGigRtgtlvaayllel.........ek

FVDILDTIARLRMLRG-AACMKAEQFVFLSMSVLEY
........|..|. |   |    ||  || . .|..
glsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 91-334 3.2e-12 41.2 In-house 7-237 (237) alignment 
Range on Protein: 91-334
Range on HMM: 7-237/237.0
NKFGEIQVYEQTRVRAV-HRQGHNYLNSSWIDGYRETR-KFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL---DEKGKPFVPvKIGEPLVIDDMTI
|..|.|..|...||       | .|.|.....|.  |  |.| |  |.  |  .||. |.. .  ..| |  |.   ..| . . | .  .|     .|.
nrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaaygvltv

ELDNIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDlladmnhmrtiLRKQGLEKKIfDDSQRTPMTLVCFDGFSRSCTLVALD
 |    .    |  |.|   .  ..  . .    .. | . | ||. . .|            .||. ...     |. .|  . |  |  |.  .. .|
slkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallr...........frkniinrsp.hvsesgpwiihcsagvgrtgiflvid

ILCQRltaSHEigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
 . ..   ..|     ||| . .  .   |       .|.||.  ..||
amlrq...ake..kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 79-345 5.1e-12 40.4 In-house 33-286 (307) alignment 
Range on Protein: 79-345
Range on HMM: 33-286/307.0
RTVDAFFDHPELNKFGEIQVYEQTRVR-AVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVKI
 ||.||   .. |.. .... ...|.   ..    .|. . ..    . .|||.|  |. ... .||  . . .   |. ||....    | . . |.. 
vtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

GEPLVID--DMTIELDNIRKVRPATYSSVLKISEKGV---ESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHmrtilrkqglekkifddsQRTPMTL
|. ||      || ..|.   . |    ......  |   .  .|.  | .. |   | ||     ..||  ..                   .. |. .
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry..................dtnpvvv

VCFDGFSRSCTLVALDILCQRLTAsheiGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHHLVNVE
 |  |  || |.||. .. ... |    |    |. . .  ||  |  |  .  |...|   .||| .  .    |
hcsaGvGrsGtivaislvqdkmia....Ginckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyketye
0044763 (Phosphotyrosine protein) phosphatases II 109-330 7.3e-12 40.8 In-house 15-165 (178) alignment 
Range on Protein: 109-330
Range on HMM: 15-165/178.0
RQGHNYLNSSWIDGYretrkFIVAPSPMsesvAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGeplviddmtieldnirkvrpatyssvlkis
 ..  |.| |.|...     ..... |.    |.... . . .   .|.|.| |    .|  |  | . |                              
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

ekgveshktvILLTYSGWGKLGYPQKPSDILDLLADMNHMRtilrkqglekkifdDSQRTPMTLVCFDGFSRSCTLVALDILCQRltasheigtpFVDIL
          |   . ..   | |. .. .|.... ... .              |..  |    |  |..||.||||.......           ... 
..........iqylhipipDhgvpdllehflefvefieeal..............dekggpvlVHCsaGvgRsgtlvaaylmkkl..........glsle

DTIARLRMLRGaACMKAEQFVFLSM
. |...|. |  ..   .|  .| .
eaielvrerRp.ivpnpgqlrqLye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 100-333 9.3e-12 39.3 In-house 63-278 (301) alignment 
Range on Protein: 100-333
Range on HMM: 63-278/301.0
EQTRVRAVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCEL---LDEKGKPFVPVKIGEPLVIDDMTIELDNIRK-VRP
 .| |. .       . . ||.   ....||.. .|....   ||  .   .   .| |..    | || . ..||||.| | |.  .|.. |  . .. 
PstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnk

ATYSSVLKISEKGVE-SHKTVILLTYSGWGKLGYPQKPSDILDLladMNhmrtILRKqglekkifddSqRTPMTLVCFDGFSRSCTLVALDILCQRLTAS
 ..   |.. .   . . .||.   || | . | |.   .. ||   |.    ...|          | . |. . | .|  || .... ..| ... | 
kiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdl...me....lvkk..........s.ekPivvhcsaGiGrsvafigteylarevead

HEIgtpfvDILDTIARLRMLRGAACMKAEQFVFLSMSVL
 .|     .. .....||  |  .  . .|. .. .  .
pti.....eltealkhlrehrwngvqtnsqlywmtlGtv
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 54-339 1e-11 38.8 In-house 19-288 (302) alignment 
Range on Protein: 54-339
Range on HMM: 19-288/302.0
FIKLLSTSSVGKEFSHFSSLPLSRLRtVDAFFDHPELNKFGEIQVYEQTRVRAVHrQGHNYLNSSWIDGYRETRKFIVAPSPMSESV---AQFWRCVFDR
..| | |..| ||| . ...  .  .   || .... |.  .........|.  . .  .|.| | ..    ||. |.|  | ..|.   ..||| ||..
lvksldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvklea.epdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

NSLIVVTLCELLDEKG--KPFVPVKIGEPLVIDDMTIELDNIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmrti
.   || |    . |   . . | | |. .  ..| .    . |.  ...  |. .  .|.     . .   . | .   |.| ...    |..      
kivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakv......

lrkqgLEKKIfddSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEigtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRH
      .|||   .   .. .|   |  |  ....| .  ..|....|     . | .... .|  | .|   ..|.|.| ...| |  ..
.....fakki...kadentvivSknGaGRagafltlavaveklqkgke.....pnikeivksiRsqRpravdslkQyvslyialllyikkk
0051082 (Phosphotyrosine protein) phosphatases II 112-330 2e-11 39.2 In-house 3-147 (151) alignment 
Range on Protein: 112-330
Range on HMM: 3-147/151.0
HNYLNSSWIDGYretrkFIVAPSPMSesvaQFWRCVFDRNSLIVVTLCELLDEK---------Gkpfvpvkigeplviddmtieldnirkvrpatyssvl
 .|.| |...|.     ...   |..    .|.. . . .   .|.|...   .         |                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

kisekgveshKTVILLTYSGWGKLGYPQKPSDILDLLADMNHmrtilrkqglekkifddSQRTPMTLVCFDGFSRSCTLVALDILCQRltasheigtpfV
           .|. . . .|   | |. .  .|..|  ...                  .  |.   |  | .|. |||||......           |
..........ievlhipildwpdpglplsfdavleflellld.................kkngpvlvHCsaGkgRTGtlvalylmllg...........v

DILDTIARLRMLRGAACMKAEQFVFLSM
.. .... .|. |. .    .||.|. .
sleealeeyrlkrpgvvqpnqqflfqlf
subfamily_eak_pd Subfamily eak 99-340 5.2e-11 36.5 In-house 65-309 (332) alignment 
Range on Protein: 99-340
Range on HMM: 65-309/332.0
YEQTRVRAVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDDMTIELDNIrkVRP
. . |. .  .    |.|.| ..     ||.|..  .  . |  ||. |....|  .| | | ..   ||   . | |  | |    . .|  .   |. 
rylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkr

ATYSSVLKISEKGVESHKtVILLTYSGWGKLGYPQKpSDILDLLADMNH---MRTILRKQGLEKKIFDDSQRTPMTL----VCFDGFSRSCTLVALDILC
. .   | . .|| |.|. |   .. || ..  |.   | | |   | .   .  |  |. | . ..   . || .      .  | .|. ..| .|.| 
niletrllelskGnethr.vlhykvfGwtettlpky.edflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidlli

QRLTASHeigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHH
. . .     .    . | | . .  |  . . | |  |.   ||.|  | .
rlidnkk...knlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 79-175 2.8e-10 34.2 In-house 26-123 (332) alignment 
Range on Protein: 79-175
Range on HMM: 26-123/332.0
RTVDAFFDHPELNKFGEIQVYEQTRVRAVHRQGH-NYLNSSWIDGYRETRKFIVAPSPMSESVA-QFWRCVFDRNSLIVVTLCElLDEKGKPFVPVKIG
 | | |..  ..|.   . .....||    ..|. .. |.||.||| .   .|.| .|. .     ||| | .|.  ... . . .||| |   |  | 
ntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd.idekqkrkapydis
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 89-345 6.8e-10 33.2 In-house 50-296 (305) alignment 
Range on Protein: 89-345
Range on HMM: 50-296/305.0
ELNKFGEIQVYEQTRVRAVHRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDE---KGKPFVPVKIGEPLVIDDMTi
. |.. ..   .. ||.      |.|. . ..    ....|| . .|. .. |.||   .. .   .  ||.||.    |   . . | .. | ...   
gknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg.

eldniRKVRPATYSSVLKISEKGVES--HKTVILLTysGWGKLGYPQKPS---DILDLLADMNHMrtilrkQGLEKKIFDDSQRTPMTLVCFDGFSRSCT
     .|.     |||    .|  ..   .||...   | |.     .     |  |       .        ||  .   . . |... |  |  |. .
.....qkisvkfessvtlkfrkdakakvtetvlvie..gpgekarkvthyhwidwpdrgvpaadl......ailellekarpskgpivvhcsagigrtgs

LVALDILCQRLTASHEIGtpfvDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYAIRHHLVNVE
.| |. ....| | . |     |    . ..|  |  .    .|..|.   .|.|  ...|...|
vvmleyildqllagqiie....dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkklldee
subfamily_CG42327_pd Subfamily CG42327 108-241 5.1e-09 30.2 In-house 52-189 (319) alignment 
Range on Protein: 108-241
Range on HMM: 52-189/319.0
HRQGHNYLNSSWIDGYRETR-KFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLdEKG----KPFVPVKIGEPL--VIDDMTIELDNiRKVRPATYSS
  .  .||..|.. ||....  .| |  .. .| ..||| |....| ..|.|..|  |.|      ..| | . .   .  |. . | . |.|.   . |
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls.elGikvcaeylPtketldntslyGdilvtlkg.revkdryais

VLKISEKGVESHKTVILLTYsGWGKLGYPQKPSDILDLLAD
 | . .   |  . .    |  | . . | ... .. .| .
tlllkrvdkeesrelthywy.kwleaevPaeeaaliamlle
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 91-236 2.7e-08 28.0 In-house 37-187 (297) alignment 
Range on Protein: 91-236
Range on HMM: 37-187/297.0
NKFGEIQVYEQTRVRAVH-RQGHNYLNSSWIDGYRET--RKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELL---DEKGKPFVPVKIGEPLVIDDMT
|.. .|  ...|||.      ...|.|. ..    |    |.|.|  |.|..| .||. |....  ..| ...|     .|  |. |   .| |   |. 
nryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvv

IELdnIRKVRPAtYSSV----LKISEKgvESHKTVILLTYSGWGKLGYPQKPSDIL
.|   . ..    .  |    |..  .  . .. |    . .|   | |    |. 
vef..lsstsde.fdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlv
subfamily_CG42327_pd Subfamily CG42327 261-336 2.8e-08 27.8 In-house 244-315 (319) alignment 
Range on Protein: 261-336
Range on HMM: 244-315/319.0
DSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEIgtpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
 ... |... | ||  |. ...| ||  ..|  |..     ||| ...  .|  |. | .. ||. |.   . |||
resqGPlvvhcsdGvGrtGlviasdiairsleeskrs....vdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 138-336 5e-08 27.3 In-house 39-221 (255) alignment 
Range on Protein: 138-336
Range on HMM: 39-221/255.0
ESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDDMTIELD-NIRKVRPATYSSVLKISEKgvESHKTVILLTYSGWGKLGYPQKPS
 .|..|.. .   ..  || ||.. .   || . . |..  | |.. |...    .. .|   |   .....||     .||   .| || .   |. . 
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgek..kkthtvkhysykGWieknaPelar

DILDLLadmnhmrtilrkqglekKIFDDSqrTPMTLVCFDGFSRSCTLVALDILCQRLT-ASHEIGTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSV
.|| .|                 |.  ||   .. ..|  |  || ..|  ... |..  . ..  |  .| |  .  ||  | .|  .  |. |  . |
eilnil.................kvvrds..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv

LEYA
|.. 
ldlv
subfamily_ptpA1_pd Subfamily ptpA1 91-159 7.1e-08 26.6 In-house 51-121 (418) alignment 
Range on Protein: 91-159
Range on HMM: 51-121/418.0
NKFGEIQVYEQTRVRA---VHRQGHNYLNSSWIDGYReTRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLC
|.. .|   ..|||.      ..| .|.|. .|||    ..||..  |. ...|.||| |..    |.| | 
nrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmls
0048076 (Phosphotyrosine protein) phosphatases II 172-332 7.8e-08 27.6 In-house 5-139 (145) alignment 
Range on Protein: 172-332
Range on HMM: 5-139/145.0
VKIGEPLVIDDMTIELDnIRKVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMRTIlrkqglekkifddsqRTPMTLVC
 .| . | . ...  || ..  .      || ..       ...| . | .|   | |. ....|..|. ... .                   |.   |
seilpglylgslptald.lellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke...............ggpvlVHC

FDGFSRSCTLVALDILCQrltasheigtPFVDILDTIARLRMLRGAACMKAEQFVFLSMSV
  | .|..||||.... .            |.. ......|. |  |..  .|. || . .
saGvgRtgtlvaaylmll..........lgvsleealelvrsqrpgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 211-329 1.1e-07 27.2 In-house 45-138 (144) alignment 
Range on Protein: 211-329
Range on HMM: 45-138/144.0
SHKTVILLTYSGWGKLGYPQKPSDILDLLADMNHMrtilrkqglekkifdDSQRTPMTLVCFDGFSRSCTLVALDILCqrltasheigTPFVDILDTIAR
  ...| . . .|   | |. ....|..|. ...                 ..  |.   |  |..|..||||....           .  ... ...|.
leregiqylhlpwpDhgvpdllellleflefieea...............leeggpvlVHCsaGvgRtgtlvaaylmk..........klglsleealal

LRMLRGAACMKAEQFVFLS
.|. |  |..  .|. || 
vrsrrpgavpnpgqlrfLl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 91-337 1.5e-07 25.3 In-house 59-290 (305) alignment 
Range on Protein: 91-337
Range on HMM: 59-290/305.0
NKFGEIQVYEQTRVRAVHRQGHNYLNSSWIDGY-RETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD---EKGKPFVPVKIGEPLVIDDmTIE
|.. .. . .|. |.  . .  .|. . ..       ..||.|  |. ... .||  | ...   .| ||  ..    |   . |.  || | .    | 
nryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelks.giv

LDNIRKVRPATYSSVLKISEKGVES----HKTVILLTYSGWGKLGYPQKPSDILDLLADMnhmRtilrkqglekkifddSQRTPMTLVCFDGFSRSCTLV
..|.   .|    . ..|.   .      . .|  | .. |   | |      |.||. .   |                 . |. . |  |  |. |.|
venvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai...r...............gskvpivvhcsagigrtgtiv

ALDILCQRLTASHEiGTPFVDIldtIARLRMLRGAACMKAEQFVFLSMSVLEYAI
|.. . ....  ..   |. ..   .  ||  |  .  .  |..|.   .|.| .
aieyilekiaenkp.cppmpel...vkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 102-225 1.9e-07 25.4 In-house 8-123 (130) alignment 
Range on Protein: 102-225
Range on HMM: 8-123/130.0
TRVRavhrqGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKgkPFVPVkiGEPLV--IDDMTIELDNIRKVrPATYS
.|..     |..|.| |..     |.... .  |....  .||. ...|   ..| |  . .|    . |    |||    .|... | .  ..     .
srlq.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed..eywpd..sePlewyeediivtltdrdef.knika

SVLKISEKGVESHKTVILLTYSGWGK
| |.|... .|||... ..  | |  
snleiesdlneshqaltmfqisnwps
subfamily_egg_pd Subfamily egg 98-330 3.6e-07 24.2 In-house 51-264 (307) alignment 
Range on Protein: 98-330
Range on HMM: 51-264/307.0
VYEQTRVRAVHRQGH---NYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLD-EKGKPFVPVKIGEPLVIDDMTIELDNIRKV
  . .||.   |.|    ... .  ..|     .||.| .|. ..| .||| ||  .   .| |    . |. . . |    ..||.   .....|..  
ckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvd

-RPATYSSVLKISEKGVEshktvilltysgwgklgypQKPSDIL------DLLADMNHMRTILRKqglekkIFDDSqrTPMTLVCFDGFSRSCTLVALDI
 ..     | |.   | .                   ..   .       . ..|.     .|||      . . |  .|. . ...| |...||||..|
skadplfrvtklklvGgd...................deerflehwqgdvnnssdvysplrvlrk......lrnls..kpvvvqdilGvskaatlvaiei

LCQRLTASheiGTPFVDILDTIARLRMLRGAACMKAEQFVFLSM
    |       .    .| ..  ||. |  .   . ...|.  
allsllrG...pitkslvlravvflrlrrrlsvesvllylfvyr
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 120-332 4.6e-07 23.6 In-house 83-284 (302) alignment 
Range on Protein: 120-332
Range on HMM: 83-284/302.0
IDGYRETRKFI-VAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGK---PFVPVKIGEPLVIDDMTI-------ELDNIRKVRP-ATYSSVLKISEK
.||  . .|   . . |  ... ..|  . . |  ||| ||.. ... |   ..   |.|. |     |.       .|..    .    |.  .| ..|
mdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekk

GVESHKTVILLTYSGWGKLGYPQKPSDILDLLadmnhmrtilRkqglekkiFDDSQRTPMTLVCFDGFSRSCTLVALDILCQrLTASHEIgtpfVDILDT
  . .||| .|..|.| . | |...   ||.|          .        | .| .. . . |  |  |. ||||.    | | . ...     |.|. 
kkkvkktvdilafsawpdhGapkeaytaldil..........k........fcesykknvlvhcsaGvGrtGtlvaikyGiq.lcskkkv....tdllsi

IARLRMLRGAACMKAEQFVFLSMSV
.  .|  |  |  ...| ..| . |
vlpvrqcryGavqdeqqliylllcv
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 91-334 6.8e-07 23.7 In-house 11-238 (239) alignment 
Range on Protein: 91-334
Range on HMM: 11-238/239.0
NKFGEIQVYEQTRVRA--VHRQGH-NYLNSSWIDGYRETRK-FIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGKPFVPVKIGEPLVIDDMTIE
|.. .|  |...||    .  . | .|.|.|..  |  . | .| .   .. |  .||| ...    ..| |  |.. . |              .. . 
nryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvt

LDNIRkVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILdlladmnhmrtilrkqGLEKKIFDDSQ--RTPMTLVCFDGFSRSCTLVAL
| .   |        . .|. |    . |    .. |   | ||  . .|                || .||  ||     |  . |  |  |. ... .
lrkte.vfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl................glrrkitkdslpgarpwvihcsagvgrtgaflvi

DILCQRLTASHeigTpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
| . ..    .   |  |||.. .  .|  |      .||.||. ..|||
damlrqakkqk...t..vdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 109-227 9.2e-07 22.7 In-house 119-234 (244) alignment 
Range on Protein: 109-227
Range on HMM: 119-234/244.0
RQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKgkPFVPVKigEPL--VIDDMTIELDNIRKVRpATYSSVLKISE
  |  |.|.|..     | ..|..  |....  .||. ...|   ..| |  . .|    . |    |||    .|.|. | .  . .    .| |.|  
smgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed..eywpds..eplewyeeditvtltdrdefk.nikasnleies

KGVESHKTVILLTYSGWGKLG
   |||... ..  | |   |
dmneshqaltmfqisnwpsdg
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 91-334 9.5e-07 23.2 In-house 12-239 (239) alignment 
Range on Protein: 91-334
Range on HMM: 12-239/239.0
NKFGEIQVYEQTRVRA--VHRQGH-NYLNSSWIDGYRETRK-FIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEKGKPFVPVKIGEPLVIDDMTIE
|.. .|  |...||    .  . | .|.|.|..  |  . | .| .   .. |  .||| ...    ..| |  |.. . |              .. . 
nryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlrvt

LDNIRkVRPATYSSVLKISEKGVESHKTVILLTYSGWGKLGYPQKPSDILdlladmnhmrtilrkqGLEKKIFDDSQ--RTPMTLVCFDGFSRSCTLVAL
| .   |        . .|. |    . |    .. |   | ||  . .|                || .||  ||     |  . |  |  |. ... .
lrkte.vfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl................glrrkitkdslpgarpwvihcsagvgrtgaflvi

DILCQRLTASHeigTpfVDILDTIARLRMLRGAACMKAEQFVFLSMSVLE
| . ..    .   |  |||.. .  .|  |      .||.||. ..|||
damlrqakkqk...t..vdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 82-336 1.2e-06 22.4 In-house 42-279 (303) alignment 
Range on Protein: 82-336
Range on HMM: 42-279/303.0
DAFFDHPELNKFGEIQVYEQTRVravHRQGHNYLNSSWIDgYRETRKFIVAPSPMSESVAQFWRCVFDRNS---LIVVTLCElLDEKGKPFVPVKIGEPL
. | .  . |.| .. . ....|   .     |. .|...    ..| |..  |.| . |.||. . ...    |...| .|  |. |  .|  .  . |
nqfvknmdknrfvdvicldhskv...klsdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdse.ydklggdsvfprnqdfl

VIDDMTIELDNIRKVRPAtYSSVLKISEKGVESHKTVILL-TYSGWGKLGYPQKPSDilDLLADMNHMRTILRKqglekkiFddSQRTPMTLVCFDGFSR
 ... .| . ....|  .    |||.      ..|. . .  |  | .   | . |    .. ..  ....|||       .  |. ||   . . |  |
kfeersirvgefkrvelg.dgwvlkvlsvsngdyksflhvhhykawphnsipsdgsp..kfvkqiwqlqsvlrk.......y..sdstptvymslsgcgr

SCTLVALDILCQRLtaSHEigTPFVDILDTIARLRMLRGAACMKAEQFVFLSMSVLEYA
. |.  ..     |    |   . .|..  .  .|  |  |. .  || ..   . |. 
agtfalfetahlsl..hse..qasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 262-338 2.4e-06 21.9 In-house 189-261 (290) alignment 
Range on Protein: 262-338
Range on HMM: 189-261/290.0
SQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEiGTPFVDILDTiarLRMLRGAACMKAEQFVFLSMSVLEYAIR
 ..||. . | || ||| .| |... .| .  ...  . ..|.|..   ||  |  | ..|... |    .. .||.
asktpvivHcvdGiSrsAalaaiilgyQkiaetsg.svkledvlka...lrkqralaitsalelafvdagivllaie
Mic1 Colon cancer-associated protein Mic1-like 236-326 4.8e-06 12.4 Pfam-A 36-125 (167) alignment 
Range on Protein: 236-326
Range on HMM: 36-125/167.0
LDLLADMNHMRTIlrKQGLEKKIFDDSQRTPMTLVCFDGFSRSCTLVALDILCQRLTASHEIGTPFVDILDTIARLRMLRGA-ACMKAEQFV
 ..||  ... ..  .| .. |. .||    . |. .. .      ...|.| .. .|. ||   ...    .. ||  |.     |..   
iktLaeskrfsel..qqlvsykvledSKelAflLLsleaqdsavrqlgvDmLrrlslahdeivevllekgqvldAlRfarkvrklekvsark
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 82-165 8.9e-06 19.6 In-house 38-120 (312) alignment 
Range on Protein: 82-165
Range on HMM: 38-120/312.0
DAFFDHPELNKFGEIQVYEQTRVRAVhRQGHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEK
 ||.   .||.. .||.... |      .   |. . ..       .|... .|. .....||. ..   |  .. || .... 
taflkfkdlnrypniqcwdrgrftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedg
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 80-168 9.6e-06 19.4 In-house 45-134 (310) alignment 
Range on Protein: 80-168
Range on HMM: 45-134/310.0
TVDAFFDHPELNKFGEIQVYEQTRVRAV-HRQ-GHNYLNSSWIDGYRETRKFIVAPSPMSESVAQFWRCVFDRNSLIVVTLCELLDEkGKP
| .|. ..   |.. .. . ...||.    .   ..|. . ..        ||..  |.  .. .||| .|.  .  .. ||   .| |.|
tyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgee.grp