Gene T20B6.1 in Caenorhabditis elegans

Synonym: CELE_T20B6.1, T20B6.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP185_AA protein Get Run
CeleP185_AA_4-217 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 6-220 2.3e-122 402.1 In-house 61-301 (302) alignment 
Range on Protein: 6-220
Range on HMM: 61-301/302.0
VDFLNDQVF----------QGPMDGTEDKKDGN-----PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTD
 ||.|..|.          ||||||||.|.. .     |||||.|||||.|.|.||||.||||||||.|||||||||||||||.||||||..||..||||
ndfinanvlkldeikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd

LKEFTDKKGFTLYTVEITNSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIEL-----------LI
|.||||||.|.||||||.|.|||.. |||||||.||.|||||||.|||.||..||||||||||||||||||||||||||||||||.|           ..
leeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsiv

MPVRQCRYGAVQDESQITYLLLFVTKGLMEKVPVTYLHSFN
.|||||||||||||.|..||||.||||||||..|.||.||.
lpvrqcryGavqdeqqliylllcvtkglmekagvlylrsfd
0036941 (Phosphotyrosine protein) phosphatases II 28-215 7.4e-46 152.2 In-house 85-285 (297) alignment 
Range on Protein: 28-215
Range on HMM: 85-285/297.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDlkeftDKKGFTLYTVEITNSkkKDAPKKTVDILYFSG
 |...|.|..|  . ..|| . | |...|| . .|||.|.....|..|..|........|...     .....||.|.|.|.   .. ...|| .... |
gPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt..gngesrtvthfhytg

WPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGIELLI--------------MPVRQCRYGAVQDESQITYLLLFVTKGL
|||||.|. ... |........       .. |||||||||||.||..|. . ...|                 .|..|.|||| ..|  .|  .. . |
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

MEKVPVTY
. | .. .
kkkltkep
0040438 (Phosphotyrosine protein) phosphatases II 15-218 2.2e-44 147.4 In-house 92-287 (317) alignment 
Range on Protein: 15-218
Range on HMM: 92-287/317.0
QGPMdgtedkkdgnpkKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkkKD
|||.            ..|.|..|  . ...| . | |....| . .|||.|...  |..|..|... .......       ..|.||.|.|....  .|
qgPl............pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl..gd

APKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQITYL
 .. || .... ||||||.|.   . |..|......    .. ||||||||||||||..|. .            .|  .  .|..|.|||| ..|. .|
sesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl

LLFVTKGLMEKVPVTYLHS
  .. . |. |.. .....
ydalleylkrkltlepase
0050432 (Phosphotyrosine protein) phosphatases II 28-207 6.6e-44 145.9 In-house 115-299 (308) alignment 
Range on Protein: 28-207
Range on HMM: 115-299/308.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVG-GVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSKKKdaPKKTVDILYFS
 |...|.|..|  . ..|| . | |...|| . .|||.|. ...| |.|..|...........       ....|..|.|.||....  . .|| .... 
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdg..esrtvthfhyt

GWPDHGAPQEAYPALEMLKFCESY--KKNVLVHCSAGVGRTGTLVAIKYGIELL-----------IMPVRQCRYGAVQDESQITYLLLFVTKGL
.|||||.|... . |..|......  .....||||||||||||..|. . .|.|           .  .|..|.|.||...|  .|   . . |
nWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl
0047943 (Phosphotyrosine protein) phosphatases II 28-203 5.2e-42 139.6 In-house 84-268 (273) alignment 
Range on Protein: 28-203
Range on HMM: 84-268/273.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGG-VLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSKKKDapKKTVDILYFS
.|...|.|..|  . ..|| . | |...|| . .||| |.....|. .|..|... ......|       |...|..|.|.||.. ..  ..|| .... 
gPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtge..srtvthfhyt

GWPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGIELL-----------IMPVRQCRYGAVQDESQITYLLLFV
||||||.|.   . ||.......       .. |.||||||||||||..|. . ...|           .  .|..|.|.|| ..|. .|  ..
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 28-205 5.6e-42 139.9 In-house 114-302 (307) alignment 
Range on Protein: 28-205
Range on HMM: 114-302/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkKKDAPKKTVDILYFSG
.|...|.|..|  . ...| . | |...|| . .|||.|..|. |..| .|..  .......       ..|.|..|.|.|.. ... .  || .... |
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......ldgytvrtlevtdl.dgtgesrtvthfhytg

WPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGIELL--------------IMPVRQCRYGAVQDESQITYLLLFVTK
|||||.|.   ..|.... ...       .. ||||||||||||||..|. . ...|              .  .|..|.|||| ..|. .|  .. .
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0046845 (Phosphotyrosine protein) phosphatases II 28-208 7.1e-42 139.1 In-house 84-275 (284) alignment 
Range on Protein: 28-208
Range on HMM: 84-275/284.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkKKDAPKKTVDILYFSG
 |...|.|..| .. ..|| . | |...|| . .||| |.... |.||..|... .......       |...|..|.|.||  . . . .|| .... .
gPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnl.gytgesrtvthfhyts

WPDHGAPQEAYPALEMLKFCESY------KKNVLVHCSAGVGRTGTLVAIKYGIEL--------------LIMPVRQCRYGAVQDESQITYLLLFVTKGL
|||||.|... . ||.|......      .. ..||||||||||||..|. . .|.              ..  .|..|.|.|| ..|. ..  ..   |
wpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

M
.
k
0051299 (Phosphotyrosine protein) phosphatases II 28-203 1.2e-40 135.2 In-house 99-282 (288) alignment 
Range on Protein: 28-203
Range on HMM: 99-282/288.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNS--KKKDAPKKTVDILYF
 |...|.|..|  . ..|| . | |...|| . .||| |...  ||.|..|... .......       ....|..|.|.||    ..|  ..|| ....
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhy

SGWPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYGIEL-----------LIMPVRQCRYGAVQDESQITYLLLFV
 .|||||.|. . . |..|... ..    .. |.||||||||||||..|. . .|.           ..  .|..|.|.|| ..|. ..   .
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
Y_phosphatase Protein-tyrosine phosphatase 29-200 4e-40 133.0 Pfam-A 50-230 (235) alignment 
Range on Protein: 29-200
Range on HMM: 50-230/235.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIdvktdLKEFTDKKGFTLYTVEITNSKKKDAPKKTvDILYFSGW
| |||.|..|... |..| . |.|.| .| ...|||.|.... .. |..|......       || .|.|..||...|....|........   | . .|
PlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnW

PDHGAPQEAYPALEMLKFCESYK----KNVLVHCSAGVGRTGTLVAIKYGIELLIM-----------PVRQCRYGAVQDESQITYLL
||||.|... . |.... .|..|    ..|.||||||||||||.||... .| |              .|..| |.||...|  .| 
pdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly
Y_phosphatase Protein-tyrosine phosphatase 29-200 4e-40 133.0 In-house 50-230 (235) alignment 
Range on Protein: 29-200
Range on HMM: 50-230/235.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIdvktdLKEFTDKKGFTLYTVEITNSKKKDAPKKTvDILYFSGW
| |||.|..|... |..| . |.|.| .| ...|||.|.... .. |..|......       || .|.|..||...|....|........   | . .|
PlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnW

PDHGAPQEAYPALEMLKFCESYK----KNVLVHCSAGVGRTGTLVAIKYGIELLIM-----------PVRQCRYGAVQDESQITYLL
||||.|... . |.... .|..|    ..|.||||||||||||.||... .| |              .|..| |.||...|  .| 
pdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly
0039614 (Phosphotyrosine protein) phosphatases II 28-210 6.9e-40 132.7 In-house 108-292 (297) alignment 
Range on Protein: 28-210
Range on HMM: 108-292/297.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkKCAEYYSDKVGgvlKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNskkKDAPkKTVDILYFSG
 | ..|.|..|  . ...| . | |...|| .  |||.|.....|   ..|... ....|..       ..|.|..| |.||   .. . .||  . . |
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn...nges.rtvthfqytg

WPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGI-----------ELLIMPVRQCRYGAVQDESQITYLLLFVTKGLMEK
|||||.|. .   ||.|.....       .. ||||||||||||||..|. . .           .  .  .|..|.|||| .||. .|  .. . |. |
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0040439 (Phosphotyrosine protein) phosphatases II 15-205 3.4e-39 130.3 In-house 60-244 (249) alignment 
Range on Protein: 15-205
Range on HMM: 60-244/249.0
QGPMDGtedkkdgnpkksTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkkKD
|||...            |.|..|  . .... . | |.|.|| . .|||.|...  ||.|..|... ....|..       |...|..|.|.||.  .|
qgPlpe............tvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl..yd

APKKTVDILYFSGWPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQIT
 .. ||  ... .|||||.|.   ..|.... ...       .. ||||||||||||||..|. .            .|  .  .|..|.|||| ..|. 
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

YLLLFVTK
.|. .. .
flyealle
0045098 (Phosphotyrosine protein) phosphatases II 28-207 6.9e-39 129.3 In-house 71-272 (278) alignment 
Range on Protein: 28-207
Range on HMM: 71-272/278.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTDlkeftDKKGFTLYTVEITNSKKKDAPKKTVDILYFSG
 |..||....|  . .... . | |...||.. .|||.|. .  ||.| .|...........      |.   . ..|. ......| .. .| .|.. .
gPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylp

WPDHGAPQEA--YPALEMLKFCES-----------------YKKNVLVHCSAGVGRTGTLVAIKYGIEL---------LIMPVRQCRYG-AVQDESQITY
|||||.| .    . ||.|.|...                  .. |||||||||||||||||. . .||          .  .|..| | ||| ..|. .
wpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrf

LLLFVTKGL
|  |. . |
lyefllell
0043336 (Phosphotyrosine protein) phosphatases II 28-203 1.6e-38 128.2 In-house 95-273 (278) alignment 
Range on Protein: 28-203
Range on HMM: 95-273/278.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSdkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNskKKDAPKKTVDILYFSG
 | ..|.|..|  . ...| . | |...|| . .|||.|..   ||.|..|... .......       ....|..| |.||  ..| ...|| .... |
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn..lgdgesrtvthyhylg

WPDHGAPQEAYPALEMLKFCES----YKKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQITYLLLFV
|||||.|    . |..||.  .     .. ||||||||||||||..|. .            .|  .  .|..|.|||| .||. .|  ..
wpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 28-203 8.8e-38 125.5 In-house 59-239 (245) alignment 
Range on Protein: 28-203
Range on HMM: 59-239/245.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNskKKDAPKKTVDILYFSG
 | ..|.|..|  . .... . | |....| . .|||.|...  |..|..|... .......       ....|..|.|.||  ..| ....|  ... .
gPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtn..lgddesrevihyhylp

WPDHGAPQEAYPALEMLKFCES-----YKKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQITYLLLFV
|||||.|      |..|.|...      .. ||||||||||||||..|. .            .|  .  .|..|.|||| .||. .|  ..
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
0037934 (Phosphotyrosine protein) phosphatases II 28-203 2.1e-35 117.9 In-house 51-238 (243) alignment 
Range on Protein: 28-203
Range on HMM: 51-238/243.0
NPKKSTCEK----HWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSdkvGGVlKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNsKKKDAPKKTVDIL
 | ..|.|     .|  . .... . | |...|| . .|||.|..   |.|  .|... .......       ....|..|....| .. | ....|  .
gPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtllseeh.......lddytvrtlllen.ldlddltrlvihy

YFSGWPDHGAPQEAYPALEMLKFCESY------------KKNVLVHCSAGVGRTGTLVAIKYGIE-------LLIMPVRQCRYG-AVQDESQITYLLLFV
.. .|||||.|..  . |..|... ..            .. |||||||||||||||.|. . ..         .  .|..| | ||| .||. .|  ..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
DSPc_SM00195 29-179 6.8e-35 116.0 In-house 77-223 (263) alignment 
Range on Protein: 29-179
Range on HMM: 77-223/263.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLkeftdkKGFTLYTVEITNSKKkdAPKKTVDILYFSGW
|..||.|..| .. ...| | | |....| ...||..|. .. ||  .||..|.|...|...       . ..|.|.|.|. .|    ...|  . . .|
PlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk..eetrkvtqyqyknW

PDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIELLI
||||.|... . ||.|..... |.     ..||||||||||||.|.|.. .. | 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle
PTPc_SM00194 29-179 6.8e-35 116.0 In-house 77-223 (263) alignment 
Range on Protein: 29-179
Range on HMM: 77-223/263.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLkeftdkKGFTLYTVEITNSKKkdAPKKTVDILYFSGW
|..||.|..| .. ...| | | |....| ...||..|. .. ||  .||..|.|...|...       . ..|.|.|.|. .|    ...|  . . .|
PlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk..eetrkvtqyqyknW

PDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIELLI
||||.|... . ||.|..... |.     ..||||||||||||.|.|.. .. | 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle
subfamily_PTPN12_pd Subfamily PTPN12 7-179 4.2e-30 99.6 In-house 69-235 (290) alignment 
Range on Protein: 7-179
Range on HMM: 69-235/290.0
DFLNDQVFQGPMDGTEDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDvktdlKEFTdKKGFTLYTVE
|..| .. .|. . .|      |   | . .| .|...|| | | .|  || . |||. |......  |.|| .......     .. . ...|.. |..
dYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.....ekav.dddflirtLk

ITNSKKkdapKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIELLI
....|.    ...|  . .  ||||| |. | . ||...  .....     ..||||||||||||..|| |  ||| 
veaqke....srkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellk
0041856 (Phosphotyrosine protein) phosphatases II 5-209 3.3e-27 90.6 In-house 18-173 (182) alignment 
Range on Protein: 5-209
Range on HMM: 18-173/182.0
TVDFLNDQVFQGPMDGTEDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCsfvegeekkCAEYYSdkvggvlkfgryslktidvktdlkeftdkkgftlyt
  |. |. .. |.. .|.      | .||.....  . .... . | |.         .  |.                                     
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................

veitnskkkDAPKKTVDILYFSGWPDHGAPQeAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQITY
         .  ....  ... .|||||.|   . .|.... ... ...|||||||||||||||||.      ....|  .  ||..| |.|. ..|. .
.........ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyff

LLLFVTKGLME
| |..   |. 
lqlallellll
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 28-176 5.3e-27 89.8 In-house 96-241 (305) alignment 
Range on Protein: 28-176
Range on HMM: 96-241/305.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKtidvktdLKEFTDKKGFTLYTVEITNSKKkDAPKKTVDILYFSG
 | |.| .  | .| .  |   |.|.  |||...||  |. .... . .||..|..       ||...  ....   ..|.. .. |  ..||  . .  
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsve.......lksektasdyieRklkisiede.dkesrtvlqyqltd

WPDHGAPQEAYPALEMLKFCE-SYKK----NVLVHCSAGVGRTGTLVAIKYGIE
||||| ||.|   |...|  . ..||     .||||||||||||. .|..  .|
WPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdiale
subfamily_PTPRD_pd Subfamily PTPRD 29-176 4.5e-26 86.6 In-house 99-239 (564) alignment 
Range on Protein: 29-176
Range on HMM: 99-239/564.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGgVLKFGRYSLktidvktDLKEFTDKKGFTLYTVEITNSKKKDApkKTVDILYFSGW
|...|.|  |  . ..|... | | . .| ...||..|. .| |   ..|..         .|.| .... ... | .....|....  ..|   .|  |
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltV.......tleeeeeladyeirtfklkkkksses..reVrqFhFtsW

PDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIE
||||.|..| . |.... ......     ..|||||||||||| ..|.. .|
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamle
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 29-195 1e-25 85.3 In-house 83-258 (285) alignment 
Range on Protein: 29-195
Range on HMM: 83-258/285.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLKeftdkKGFTLYTVEITNSKKKDAPKKTVDILYFSGW
|   |    | .| | ..|  . ||...||  .||| || .|.| |.|||.| .   ..| .        |  | .. ..|..   .    .. .    |
plpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeai.....agtilnaltvintedasseplymnhvqvpww

PDHGAPQEAYPALEMLKFCE---SYKKNVLVHCSAGVGRTGTLVAIKYG---------IELL--IMPVRQCRYGAVQDESQ
||. ||..| | .|. |. .     .| . |||||||||| |.| | |          ||.|  .  .|  |. |||   |
pdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmq
0051429 (Phosphotyrosine protein) phosphatases II 28-209 1.4e-25 85.9 In-house 29-227 (272) alignment 
Range on Protein: 28-209
Range on HMM: 29-227/272.0
NPKKSTCEKHWAViDQHNVAICVQLCSFVEGEEKKCAEYYS----------DKVGGVLKFGRYSLKTIDVKTDLKeftdkkgFTLYTVEITNSKKKDAPk
.| . |..  |.   ....   | |.| .| .  ||  |            | .     .|....... ... |        ..|.. ..|.  . ... 
gplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld.......yilrellltlllsagea.

KTVDILYFSGWPDHGAPQEAypALEMLKFCESyKKNVLVHCSAGVGRTGTLVAIKYG-------------------IELLIMPVRQCRYGAVQDESQITY
 .| .|.. .|||||.||||   ||.|... . ...||||||||..||||.||. .                    .|  .  .|..| ||||.| |. .
revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LLLFVTKGLME
|. .. . |..
lyeallellrs
0036282 (Phosphotyrosine protein) phosphatases II 29-201 2.7e-25 84.5 In-house 27-164 (174) alignment 
Range on Protein: 29-201
Range on HMM: 27-164/174.0
PkkstcekHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvggvlkfgryslktidvktdlkeftdkkgftlytveitnskKKDAPKKTVDILYFSGW
.       .|. . .... . |.|.. .| .  ||  |...                                          ... .....  ... .|
a.......fwemlkelgittvvmlleekelglykcinywpe..........................................lredlerlgiqylylpw

PDHGAPQEAYpALEMLKFCESY-----KKNVLVHCSAGVGRTGTLVAIKYGIELLI-------MPVRQCR---YGAVQDESQITYLLL
||||.|  .   ||..||.|..     .. |||||||||||||||||. . . .|.         ||..|    |.|| .||. .|  
pDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 29-200 3.8e-25 83.8 In-house 17-143 (152) alignment 
Range on Protein: 29-200
Range on HMM: 17-143/152.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYsdkvggvlkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkktvdILYFSGW
|   |....|  . .... . | |....|  . ||..|.                                                        ..  |
pgpntladfwrmlkelgittivmltellelgklkceqyi......................................................qylhlpw

PDHGAPQEAYPALEMLKFC----ESYKKNVLVHCSAGVGRTGTLVAI-----KYGIELLIMPVRQCRYGAVQDESQITYLL
||||.|. .   |..|.|.    .. ...|||||||||||||||||.     .. .|  .  ||..| |||. ..|. .|.
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylmllgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 28-173 5e-25 82.8 In-house 97-236 (301) alignment 
Range on Protein: 28-173
Range on HMM: 97-236/301.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLKEFTDKKgftlyTVEITNSKKKDApKKTVDILYFSG
 | |.|.|  ||.. |..|   | |. .|| .|.||.||.. |..  |. ||...|. . .. |.. . |.     |.|...| .| |  .||    .| 
gPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskr.....tlevedstgkfa.trtvthyqyse

WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKY
|.|.| |.      .....    .| ..||||||.||. .... .|
wtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigtey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 28-199 2.2e-24 81.0 In-house 89-269 (307) alignment 
Range on Protein: 28-199
Range on HMM: 89-269/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSlKTIDVKT-DLKEFT-DKKGFTLYTVEITNSKKkdapKKTVDILYF
 |...|  . ||.. |..|   . ||  .|  . || .|.  . |  | ||  . .|| |.    |... |..   . |...  ..|     .|.. | .
gplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap.ntisvanlgakklapdedlinvttlkvdwaqk....srtiqhlqw

SGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIE------------LLIMPVRQCRYGAVQDESQITYL
. |||.|.||    |...|.  .  .  |.|||||||||.||.||| .  .             |.  .|. |  |.|.| |  ||
enwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 29-179 2.5e-24 80.4 In-house 102-244 (290) alignment 
Range on Protein: 29-179
Range on HMM: 102-244/290.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTiDVKTDLKEFTDKKGFTLYTVEitNSKkkdapKKTVDILYFSGW
. |.|    | .. |..||  | ||  .|    ||..|| .| | || || ...     ..|  . . || ...  ..  . |     .. .  |    |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlc.seeddkdaniikktlsvrdkd..sGk.....ehklkhlkiksw

PDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLI
||.  .. .   | .|.        | ||||||.|||||.|||. |...|.
pdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqill
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 29-208 3.4e-24 80.4 In-house 90-272 (288) alignment 
Range on Protein: 29-208
Range on HMM: 90-272/288.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYslktidvKTDLKEFTDKKGFTLYTVEITNSKKKDAPKkTVDILYFSGW
| ..| |. | .. . .|   | || ..|   .| |||.  |.|   ..||.        |. |.  .    ..    . .||. . ..  | ||..  |
PlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.......ctvvkkkradidklvkvsllriskegeekv.ivkilhlleW

PDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAI-----------KYGIELLIMPVRQCRYGAVQDESQITYLLLFVTKGLM
.|.| |..  . | .|.  .|..| ..||.||||||||||. |             ||. |.   |. |. |.| | |  |.   | . |.
dddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell
0046846 (Phosphotyrosine protein) phosphatases II 27-205 5e-24 80.4 In-house 29-171 (176) alignment 
Range on Protein: 27-205
Range on HMM: 29-171/176.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvggV----LkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkktvdI
  |  .|... .. . .... . | |.. || .  ||. |...    .    .                                               
qgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..............................................q

LYFSGWPDHGAPQEaYPALEMLKFCESYK---KNVLVHCSAGVGRTGTLVAI-------KYGIELLIMPVRQCRY-GAVQDESQITYLLLFVTK
 .. .|||||.|.     ||.|.|....    ..||||||||.||||||||.        . .|  .  ||..|  |||| ..|. .|  |. .
ylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 29-202 6e-24 80.1 In-house 28-156 (172) alignment 
Range on Protein: 29-202
Range on HMM: 28-156/172.0
PKKSTCEKHWAVIDQHNVAICVQLCSFvegeekkcaeyysdkvggvlkfgryslktidvktdlkeftdkkgftlytveitnSKKKDAPKKTVDILYFSGW
|  .|....|. . .... . | |...                                                       . ..  ....  ... .|
plrntladfwrmlkelgithivnltel......................................................lydpellerlgiqylylpw

PDHGAPqEAYPALEMLKFCES-----YKKNVLVHCSAGVGRTGTLVAIKY-----GIELLIMPVRQCRYGAVQDESQITYLLLF
||||.|  .   ||.|.|...      .. |||||||||||||||||. .      .|  .  ||..| |||| .||. .|. |
pDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyf
0044763 (Phosphotyrosine protein) phosphatases II 35-206 1.1e-22 76.0 In-house 38-170 (178) alignment 
Range on Protein: 35-206
Range on HMM: 38-170/178.0
EKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGgvlkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkktVDILYFsGWPDHGAP
..... . ....   | |.. .|.   || .|. .. |                                               .  |.. ..||||.|
addlellkelgithivnlteelelgflkcdpywpeeag...............................................iqylhi.pipDhgvp

QEAYPALEMLKFCE----SYKKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYgAVQDESQITYLLLFVTKG
.     ||...|.|    . ...|||||||||||.|||||.      .. .|  |  ||..|  .|. ..|. .|..|  . 
dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 29-177 1.2e-22 75.3 In-house 81-227 (274) alignment 
Range on Protein: 29-177
Range on HMM: 81-227/274.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKfGRYslktIDVKTDLKEFTDKKGFTLYTVEITNSKKkdapKKTVDILYFSGW
|  .| .  | .| |..| . | |  . | .|.|||.|. |. .  .. .||    .||.   .. ........ .. . ....    ...|   ... |
PlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis.ery....gdveikvekiverndysvrklvlkyler....ersvkhywytdW

PDHGAPQEAYPALEMLKFCESYKK-------NVLVHCSAGVGRTGTLVAIKYGIEL
||| .|..| . |....  |. ..        |.||||||.||||  .||. ..  
PdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 29-179 2.6e-22 74.0 In-house 96-247 (305) alignment 
Range on Protein: 29-179
Range on HMM: 96-247/305.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKtIDVKTDL---KEFTDKKGFTLYTVEITNSKKKDAPKKTvDILYF
| . ||   | .  |..|     || ..|   |||.||.. | . ||.|     | | || .     .|...   ..   ...        .|.    ..
plektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk.isvkfessvtlkfrkdakakvtetvlviegpgekarkv.thyhw

SGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLI
  ||| | |      ||.|. . . |  . ||||||.||||..| ..| .. |.
idwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqll
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 28-172 2.9e-22 73.4 In-house 93-230 (515) alignment 
Range on Protein: 28-172
Range on HMM: 93-230/515.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDlkefTdkkGFTLYTVEITnsKKKDapKKTVDILYFSG
 |.|.. .  | .. |.||.  . .    ||.  ||..|. || |  .||| ...... ....    |   | .  .....  | .|   .||    | .
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac....t...ggikrkltvl..kgdd..srtvtqfhfte

WPDHGAPQEAYPALEMLKFCES----YKKNVLVHCSAGVGRTGTLVAIK
|||.|.|...   | ..|   .    |.  ...|||||||||| ...|.
WPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid
subfamily_PTPN3_pd Subfamily PTPN3 29-176 4.3e-22 73.3 In-house 92-233 (280) alignment 
Range on Protein: 29-176
Range on HMM: 92-233/280.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkVGGVLKFGRYSLKTIDVktdlkefTDKKGFTLYTVEITNSKKKDapKKTVDILYFSGW
| ..|... | .. .... . | | . ||   .|| .|. .  .  |..|..|.|             .| . |  . ......|.  ....  | .  |
PlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.......detksyvlrelvlkdketke..erkilqlqylaW

PDHGAPQEAYPALEMLKFCESYK----KNVLVHCSAGVGRTGTLVAIKYGIE
|||| |...   ||...  ....    . |.||||||.|||| |....  . 
pdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala
subfamily_PTPRB_pd Subfamily PTPRB 29-172 5.4e-22 73.2 In-house 102-239 (293) alignment 
Range on Protein: 29-172
Range on HMM: 102-239/293.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvggvlkfgRYSLKTIDVKTDLKEFTDKKGFTLYTVEITNskkkDAPKKTVDILYFSGW
|  .| .. | .. .... | | |   ||.  .|| ||. ..        . .    |.| .|.. .... ... ...|..    .  ...|  . |  |
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad........eepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsW

PDHGAPQEAYPALEMLKFCESYK------KNVLVHCSAGVGRTGTLVAIK
|||| |... . |....  ....      . ..||||||||||||..|..
pdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 29-181 5.8e-22 73.0 In-house 72-227 (270) alignment 
Range on Protein: 29-181
Range on HMM: 72-227/270.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFgryslKTIDVKTDLKEFTDKKGFTLYTVEITnskKKDAPKKTVdILYFSGW
|...| ...| .| ...|   | .  ..|   |||. |.. ...  .|.     .. ..|.   . . ..|. |  ....   .|   .. |   ..  |
PlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl.....edgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntW

PDHGAPQEAY------PALEMLKFC----ESYKKN--VLVHCSAGVGRTGTLVAIKYGIELLIMP
||||.|.|.         |.||.      .. .|.  .||||||||||||||.|. ....|| . 
pdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeet
subfamily_PTPRA_pd Subfamily PTPRA 28-175 9.7e-22 72.3 In-house 108-252 (330) alignment 
Range on Protein: 28-175
Range on HMM: 108-252/330.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLKtIDVKTDLKEFTDKKgFTLYtvEItNSKKKDAPKKTVDILYFSG
 ||. | |  | .| ... |  | |  . | .|.||| |. |.  |.. .|   .. .. .| |...| .| | .   .. . .... ... |  ..| .
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirve.vedetvlvdytvrk.flvq..ql.pdatrekksrlvrqfhfts

WPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYGI
||| | | |.   |..||  ..        . ||||||||||||.....  .
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavl
subfamily_PTPRG_pd Subfamily PTPRG 25-172 1.3e-21 71.4 In-house 95-241 (563) alignment 
Range on Protein: 25-172
Range on HMM: 95-241/563.0
KDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlKEFTDKKGFTLYTVEITNSKKKdAPKKTVDILY
   .| |.|..  | .| ..|||| | .  .|| . .||  |.     .....|  ... |. ..  .    .. ...  ... . |..   .|.|    
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev..lalytvrtlviknlklkkkkqc.dteklvrqyh

FSGWPDHGAPQEAYPALEMLKFCESYKKN----VLVHCSAGVGRTGTLVAIK
.. |||||.|. . | | . |  .  .|.    ..||||||||||||.....
ytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld
subfamily_PTPN6_pd Subfamily PTPN6 31-187 1.3e-21 71.9 In-house 108-277 (306) alignment 
Range on Protein: 31-187
Range on HMM: 108-277/306.0
KSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLkFGRYSLKTIDVKtdlkeftDKKGFTLYTVEITNSKKKdAPKKTVDILYFSGWPD
..| .  | .. | |  . | .   ||  ..||| |. |.      .|..|..... |       ... ..| .. ... |||   ...|  . |  |||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.......sladYilRelsvskkkkk.keerevfqyhfksWPd

HGAPQEAYPALEMLKFCESYKKN--------VLVHCSAGVGRTGTLVAIKY--------------GIELLIMPVRQCRY
|| |.. .  |..|.  .. ...        ..||||||.|||||.. |                 |. |.. ||. | 
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrs
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 29-176 1.8e-21 71.3 In-house 99-241 (290) alignment 
Range on Protein: 29-176
Range on HMM: 99-241/290.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLKTidvktdLKEFTDKkGFTLYTVEITNSKKKdAPKKTVDILYFSGW
| ..|  . | .|.|..|.| | |.. .| ...||  |..|.  .. ..| .|.|       |.| | . ...  ..|..|.... ..|..|  . .. |
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikl......lneetln.eyierklevknknsa.gakqsvtqyqitnw

PDHGA---PQEAYPALE-MLK-FCESYKKNVLVHCSAGVGRTGTLVAIKYGIE
...|    ||    ..| | |    . .. ..||||..|||.....|.. .|.
dstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 26-176 2.1e-21 71.2 In-house 95-237 (288) alignment 
Range on Protein: 26-176
Range on HMM: 95-237/288.0
DGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKtdlkeftDKKGFTLYTVEITnskkKDAPKKTVDILYF
   |  .| .. | .. ....   | | ..|||...|| ||. |. .   ..|   .. ...|       ... |.| ....     |.  . ..  . .
tqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlvesk.......eledfvlrkllle....kkkteleitqyqy

SGWPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYGIE
 .||||| |. . | ||.|.  .       ....|||||||||||| .|..  |.
laWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalid
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 28-175 2.4e-21 70.9 In-house 94-234 (315) alignment 
Range on Protein: 28-175
Range on HMM: 94-234/315.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLKEFTDKkgftlytVEITNSKKkdapKKTVDILYFSG
 |.|.. .  | .. |..|.  | .    ||.  ||. |. |. .   .|| ..........|    . |       . . .|..    ..||    | .
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvark.......lvtrksee....srtvtqfqfte

WPDHGAPQEAYPALEMLKFCES----YKKNVLVHCSAGVGRTGTLVAIKYGI
|||.|.....   |...|   .    .. ..|||||||||||| ...|.  .
wPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 28-176 4.1e-21 70.2 In-house 93-236 (287) alignment 
Range on Protein: 28-176
Range on HMM: 93-236/287.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGgvLKFGRYSLKTIDVKtdlkeftDKKGFTLYTVEITNSKkKDAPKKTVDILYFSG
 |  .|  . | .||..|| . | ||   | .|..| .|....    . .| |... .. .        ..|..  ..|..|.. |...|..|    .  
sPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.......vnagyierklevknkn.kagdkqqvkqyqitn

WPDHGAPQE-AYPALEMLKFCE----SYKKNVLVHCSAGVGRTGTLVAIKYGIE
|...|  .| .   | . .       . .  ..||||..|||.....|.  .|.
WdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin
subfamily_PTPN13_pd Subfamily PTPN13 29-177 4.1e-21 70.5 In-house 85-228 (273) alignment 
Range on Protein: 29-177
Range on HMM: 85-228/273.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRyslkTidVKTDLKEFTDKKGFTLYTVEITNSKKKDApkKTVDILYFSGW
|   |..  | .. . .. . . . . .|... ||  |. .. .  ||          .. .| . ....||.. ......|. ...  . |  | |  |
PlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsn....r..levellkvqkldgfvvralavkdsesges..revahlnfvkw

PDHGAPQEAYPALEMLKFCESYKK---NVLVHCSAGVGRTGTLVAIKYGIEL
|||| |..| . |....   . ..    ..||||||.||.|||..|.  ..|
PdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlgl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 29-173 6e-21 69.8 In-house 92-230 (281) alignment 
Range on Protein: 29-173
Range on HMM: 92-230/281.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGgvlkfgrySLKTIDVKTDLKEFTDKKGFTLYTVEItnsKKKDAPKKTVDILYFSGW
|  ..... | .. ...| . | .   .|..  ||  |. |.          .||  ||.   .. ..|. .   ....   .........|  | .  |
PvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns........elkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaW

PDHGAPQEAYPALEMLKFCES---YK--KNVLVHCSAGVGRTGTLVAIKY
||||.|...   ||  |  ..    |    ...||||||||||| .|.  
PdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 28-192 6.7e-21 69.3 In-house 89-246 (312) alignment 
Range on Protein: 28-192
Range on HMM: 89-246/312.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVlKFGR---YSLKTIDVKTDLKEfTDKKGFTLYTVEItnskKKDAPKKTVDILY
 | ..|| . | .      .  . ||.|||   .|||.| || || | ..     |.    ...   |   ||    .  | .    |    .  ..   
gplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfv.dledhrvyteycteieiggks.kdkithrvlkvvv....katgqesklnhyq

FSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIkygiELLIMPVRQCRYGAVQD
.. ||||| |.    || .|      || |. ||||||||||||. |    | .|  .|. |   |.|
waswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlali....esmiaalrhprkqnvkd
0048076 (Phosphotyrosine protein) phosphatases II 96-204 2e-20 68.4 In-house 27-140 (145) alignment 
Range on Protein: 96-204
Range on HMM: 27-140/145.0
DKKGFTLYTVeitnSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESY---KKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCR
| .  |....    .  .. .....  ... .|||||.|. .   ||.|.|.|..   ...|||||||||||||||||.      .. .|  .  ||..|
dlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqr

YGAVQDESQITYLLLFVT
 |||. ..|. .|..|..
pgavpnpgqlrflyefel
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 29-178 3.3e-20 66.9 In-house 104-248 (305) alignment 
Range on Protein: 29-178
Range on HMM: 104-248/305.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGrySLKTIDVKTDLKEFTDKKGFTLYTVEITNSKKKdapKKTVDILYFSGW
|   | .. | .. |..|   | ||  ||    |||.|.    |  |..   |   ..  .  | .       . ....| | ..   | .|  | .. |
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk..sgivvenvsgskpmerdaeiqitllnltysgdq...kmsvrhlqwtew

PDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELL
|| | |     .||.|      |  ..||||||.|||||.|||.| .| .
pdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyileki
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 28-176 3.7e-20 67.2 In-house 98-241 (319) alignment 
Range on Protein: 28-176
Range on HMM: 98-241/319.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVggVLKFGRYSLKTiDVKTdlkeftDKKGFTLYTVEItNSKKKDAPKKTVDILYFSG
 |.. | |  | .. .... | | |.  ||  . |. .|....   . ..||. ..  . .        ....    ... | |. .   ..|   ..  
aPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtl.eeee......eledyiirklkl.nkkssevetRevkhfqyte

WPDHGAPQEAYPALEMLKFCESYKK-----NVLVHCSAGVGRTGTLVAIKYGIE
||||. |..|   |..||  .  ..      . |||||||||||| ....  .|
WpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 28-173 4.4e-20 67.1 In-house 106-245 (298) alignment 
Range on Protein: 28-173
Range on HMM: 106-245/298.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLktidvktDLKEFTDKKGFTLYTVEITNSKKKdaPKKTVDILYFSG
.| ..| |  | .. .....  | | . .| .. |. .|. |.  |  ..|. ..       .|..  ..  ..  .......|..   ...|  | |. 
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv.......sllskeefadlivrklkvskkkee..kerevrqlhfts

WPDHGAPQEAYPALEMLKFCESYK-----KNVLVHCSAGVGRTGTLVAIKY
|||.|.|..|   |..|.  . ..     | |.|.|||||||.|| .||. 
WpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaids
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 29-173 8.4e-20 66.3 In-house 112-246 (319) alignment 
Range on Protein: 29-173
Range on HMM: 112-246/319.0
PKKSTCEKHWAVIDQHNVAICVQLCsfvegeEKKCAEYYSDKvgGVLKFGRYSLKTiDVKTDLKEftdkkgFTLYTVEITNS-KKKDapKKTVDILYFSG
|.. | .  | .| ..|..  | |       ..||..|.  |  .| | .|. .|  |. .. .|      ...  .|...  |.||  .. .   .| |
PldntladfWrmiweyncstivllt......kdkcsqywplk..ivikeerfkvkv.dsveetae......yvvrdielsedgkekd..irkitqfhflG

WPDHGAPQEAYPALEMLKF------CESYKKNVLVHCSAGVGRTGTLVAIKY
|||.| |. . . . ..|        |  ..|..|||||||||||. .... 
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv
0048179 (Phosphotyrosine protein) phosphatases II 105-202 1.3e-19 65.8 In-house 34-140 (144) alignment 
Range on Protein: 105-202
Range on HMM: 34-140/144.0
VEITNSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESY---KKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQ
. .|..  .. .....  ... .|||||.|. .   ||.|.|.|..   ...|||||||||||||||||.      .. .|  .  ||..|.|||. ..|
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgq

ITYLLLF
. .||..
lrfLley
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-176 1.4e-19 65.3 In-house 75-238 (318) alignment 
Range on Protein: 7-176
Range on HMM: 75-238/318.0
DFLNDQVFQGPMDGTEDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGryslkTIDVktDLKEFTDKKGFTLYTVE
|..| .  .| .   .      |   |.|  | .. . | |. | |   .|   .|.. |. .|  |  ..|     .. |  .||| .. . ..| ...
DyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsyg.....klvv..elkeevelsdyvlrefk

ITNSKKKDapKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYK-----KNVLVHCSAGVGRTGTLVAIKYGIE
.|......  ...|    .  |||.| |...   |....  ....     . ..|||||||||||. .|..  .|
vtrteeee..srqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 29-173 1.6e-19 65.5 In-house 76-210 (284) alignment 
Range on Protein: 29-173
Range on HMM: 76-210/284.0
PKKSTCEKHWAVIDQHNVAICVQLCsfvegeEKKCAEYYSDKvgGVLKFGRYSLKTIDVkTDLKEftdkkgFTLYTVEITNS-KKKDapKKTVDILYFSG
|.. | .  | .| ..|..  | |       ..||..|.  |  .| | .|. .|   | .. .|      ...  .|...  |.||  ....   .| |
PldntladfWrmiweyncstivllt......kdkcsqywplk..ivikeerfkvkvdsv.eesee......yvvrdielsedgkekd..irkirqfhflg

WPDHGAPQEAYPALEMLKF------CESYKKNVLVHCSAGVGRTGTLVAIKY
|||.| |. . . . ..|        |  ..|..|||||||||||. .... 
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 25-180 2.8e-19 64.4 In-house 71-220 (290) alignment 
Range on Protein: 25-180
Range on HMM: 71-220/290.0
KDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEK----KCAEYYSDKVGGVLKFGRYSLKTidvktdlKEFTDKKGFTLYTVEITNSKKKdapKKTV
| .. ..|| ||.| .. | .|   |.|| | | ...     ||.|. ..||. |||.  ..|        |.   ....   .....  ...   . ||
kitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.......kskekeddvetRelvvkfddee...eftv

DILYFSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLIM
.   ..|| .  ....   .|..... . .|  |.|||  |. |  .| ||. |  ... 
tHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiae
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 27-174 4.4e-19 63.2 In-house 87-223 (281) alignment 
Range on Protein: 27-174
Range on HMM: 87-223/281.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVktdlkefTDKKgfTLYTVEITNSKKKDApkKTVDILYFS
  ||| |    | .| | | .  | || |.| . .|||||.  .   .|.| ..|..  |        | .|  .| |  .  | . ..  . .    . 
qgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyeds.......tvnk..slvttrlnlsyeget..rlithwlwk

GWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYG
 |||   |. .   |..|.   .     ..||||||||.|||.|..  
ewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveia
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 28-176 5.7e-19 63.3 In-house 59-200 (250) alignment 
Range on Protein: 28-176
Range on HMM: 59-200/250.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKkCAEYYSdkVGGVLKFGRYSLKtidVKTdLKEFTDkkgFTLYTVEItnSKKKDAPKKTVDILYFSG
.| ..| |. | .. .....  | | ...| |.. . .|.   | .  |.|   ..   ..   .||.|   .|  .. .  ||.| | ...|  | |  
gPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..vekaekyGdvtvs...lls.keefad...ytkrklkl..skakkaderivrqlhfvv

WPDHGAPQEAYPALEMLKFCESYKKN-----VLVHCSAGVGRTGTLVAIKYGIE
||| | |..|  .||.||  .. ...     |.|.|||||||.|. .||.  .|
WPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 27-173 1e-18 62.5 In-house 98-239 (297) alignment 
Range on Protein: 27-173
Range on HMM: 98-239/297.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkKCAEYYSDKvgGVLKFGRYSLKTIDVktdlkefTDKKGFTLYTVEITNSKKKDapKKTVDILYFS
  |.|.| .  ||.. ...|.. | |    |... ||| |.|||  || .||  |...  |       ....||   ..|.|..| |   .. |.   | 
qmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk..gvttfGdvsvvllsv.......sereGfikrelevtkgkaka..rrvvkqyqfv

GWPDHGAPQ-EAYPA-LEMLK-FCESYKK----NVLVHCSAGVGRTGTLVAIKY
 |||.  .. .  .. |....   .....     .||||.||||||| |..|. 
eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids
0051082 (Phosphotyrosine protein) phosphatases II 35-201 1.8e-18 62.1 In-house 23-147 (151) alignment 
Range on Protein: 35-201
Range on HMM: 23-147/151.0
EKHWAVIDQHNVAICVQLCSFVEGEekKCAEYYSDKVggvlkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkKTVDILYFSGWPDHGAP
. ... . ....   | |.| .| .  .|.||. .                                                 .|  ... .|||.| |
adflellkelgiktivnlrseeerg..ycpeylpelg..............................................ievlhipildwpdpglp

QEAYPALEMLKFCESY-KKNVLVHCSAGVGRTGTLVAI-----KYGIELLIMPVRQCRYGAVQDESQITYLLL
.    .||.|.....  ...||||||||.||||||||.     .. .|  .  .|..| |.|| . |. ..|.
lsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_Ptp69D_pd Subfamily Ptp69D 28-173 3.6e-18 60.7 In-house 98-241 (307) alignment 
Range on Protein: 28-173
Range on HMM: 98-241/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGryslktiDVKTDLKEFTDKKGFTLYTVEITNSKKKD---APKKTVDILY
.|  .| .  | .| . .| . | |    | ..|||| |...      ..|       |.  .| ..  .. ..  ...... |..      .. |    
dPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.......dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyh

FSGWPDHGAPQEAYPALEMLKFC-ESYKKN---VLVHCSAGVGRTGTLVAIKY
. ||.|  .|. |   |....   | ||.|   ..|||||||||.|..||.. 
ytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 22-186 4.1e-18 60.4 In-house 29-183 (255) alignment 
Range on Protein: 22-186
Range on HMM: 29-183/255.0
EDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDvktdlkeftDKKGFTLYTVEITNSKKKDAPKKTVD
 |||  |    | .| . .| | .    | || | | . .|| .|.  .  . ||.   .. | .               | |.|||    .    .|| 
kdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.........ssadvvlrtleitstlgekkkthtvk

ILYFSGWPDHGAPQEAYPALEMLKFCESYkKNVLVHCSAGVGRTGTLVAIKYGIELLIMPVRQCR
   . ||... ||..|   |..||      | |.||||.|.||. ..| . .    .|. ...  
hysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldtte
subfamily_PTPN23_pd Subfamily PTPN23 28-174 1.4e-17 58.4 In-house 90-234 (288) alignment 
Range on Protein: 28-174
Range on HMM: 90-234/288.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRyslktidVKTDLKEFTDKKGFTLYTVEITNSKKKDapKKTVDILYFSG
 |..||    | .. .  . . | | |  | ...|...|.  . |   |||        ..  ||. .. . .  ......  ...   .|.|  | .  
aPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.......lsvtlksvretethvervlkletldada..vksvshlqlts

WPDHGAPQEAYPALEMLKFCES--------YKKNVLVHCSAGVGRTGTLvAIKYG
||..|.|.     |..|.  ||         |. ..|||||||||||.. |. |.
WpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf.alvya
subfamily_PTPRK_pd Subfamily PTPRK 28-177 9.6e-17 55.8 In-house 93-236 (314) alignment 
Range on Protein: 28-177
Range on HMM: 93-236/314.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGvlkFGRYSLKTIDVKTDlKEftdkkgFTLYTVEITNSKKKDAPKKTVDILYFSG
.|...| .  | .. ..| |  | |  .||    || .|. ..      .|   .. ...... .|      .   .  .......   ...|  . | |
gPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetell.ae......lvvrifrveklargqeeirevrqfqflg

WPDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIEL
||||. |..|   |....  .. ..    ...|||||| ||||| .||.  ...
WpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldm
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 6-172 1.2e-16 55.6 In-house 29-193 (237) alignment 
Range on Protein: 6-172
Range on HMM: 29-193/237.0
VDFLNDQVFQGpMDGTEDKK--DGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVggvlKFGRYSLKTIDVKTDlKEFTDkkgFTLY
.|..|   ..| .|||  |      | .|.|.  | .. | . .. | |  ..||.|.|| .|. .      .   |   |. .| . .||.|   .|. 
sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd....qpaaygvltvslkkk.eefsd...ytvr

TVEITNSKKKDaPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYK------KNVLVHCSAGVGRTGTLVAIK
.. ...  ..    . .    |. |||.| ||..   | . |               ..|||||||||| .. | 
slllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid
0049772 (Phosphotyrosine protein) phosphatases II 29-205 1.2e-16 56.7 In-house 92-272 (314) alignment 
Range on Protein: 29-205
Range on HMM: 92-272/314.0
PKKSTCEKH----------WAVI--DQHNVAICVQ---------------------LCSFVEGEekkcaeyysdkvggvlkfgryslkT------IDVKT
|.. |..            | ..  ...|| . |                      |... ..                                ..   
pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........................neptaadlellk

dlkeftdkkgftlytvE-------ItnskkkdaPKKTVDILYFsGWPDHGAPQEAYpALEMLKFCES--YKKNVLVHCSAGVGRTGTLVAIKYGIELL--
                |                ..  .  |..  .||..|| ...  .|.|.|.|.   ...|||||.||.|||||.|.. | . ||  
................eelydpelf........erlgikylri.pvpDgsaplled.fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgv

-----IMPVRQCRYgAVQDESQITYLLLFVTK
     .  ||..|. .   ...|  |.... .
sleealedvrlkRp.inpnpgfieqleqyefi
PTPc_DSPc_SM00012 119-178 1.3e-16 56.0 In-house 1-66 (105) alignment 
Range on Protein: 119-178
Range on HMM: 1-66/105.0
TVDILYFSGWPDHGAPQEAYPALEMLKFCESYKK------NVLVHCSAGVGRTGTLVAIKYGIELL
||  ....||||||.|.|. . ||.|. ... |.      .|.||||||||||||.||. . .. |
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqql
subfamily_PTPN1_pd Subfamily PTPN1 27-172 1.6e-16 54.9 In-house 77-222 (290) alignment 
Range on Protein: 27-172
Range on HMM: 77-222/290.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVG-GVLKFGRYSLKTIDVKTDlkeftDKKGFTLYTVEITNSKKKDApkKTVDILYF
  |  .|..  | .. ...    | |  .|| |. |||.|.  .     |..   .||   ....     .|. .|. ..|..| | ...  ...   ..
qGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklisee.....rksyytvrllelenlktqet..reilhfhy

SGWPDHGAPQEAYPALEMLKFCE---SYKK---NVLVHCSAGVGRTGTLVAIK
  ||| | |.     |..|  .    | ..    ...|||||.||.||.. . 
ttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvd
subfamily_PTPN14_pd Subfamily PTPN14 28-171 3.7e-16 54.0 In-house 100-249 (300) alignment 
Range on Protein: 28-171
Range on HMM: 100-249/300.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDK--VGGVLKFGRYSLKTidvktDLKEFTDKKGFTLYTVEITNSKKkdapKKTVDILYF
 | . |....| .. ...|.. |.| .  |.  .|. .|. ..      ..||.. . |      ..| .|.   | ....   ||.    ..|| .| .
gPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt.....kfsedsdsvittglklkhlpske....ertvwhlqy

SGWPDHGAPQEAYPALEMLKFCESYKK-------------NVLVHCSAGVGRTGTLVAI
  ||||| |..  . |. |.  .| ..              ||||||||||||| |.  
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlils
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 28-172 4e-16 53.8 In-house 99-233 (315) alignment 
Range on Protein: 28-172
Range on HMM: 99-233/315.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvggVLKFGRYSLKTIDvktdlKEFTDKkgFTLYTVeitNSKKKDAPkKTVDILYFSG
 |. .. .  | .. .....  | | . ||||..|. .|. ||    . .|....  ..     .|  ..  .|  |.       .|   ..|  | .. 
gpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrks.....eevnte..ytvrtl...svvfgdni.revvqlhyts

WPDHGAPQEAYPALEMLKFCESYKKN----VLVHCSAGVGRTGTLVAIK
||| | |. . | ... .    ...|    ..||||||||||||.....
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld
subfamily_hpo-7_pd Subfamily hpo-7 32-179 4.7e-16 53.5 In-house 45-182 (263) alignment 
Range on Protein: 32-179
Range on HMM: 45-182/263.0
STCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTdlkeftdkkGFTLYTVEITNSKKKDAPKKTVDILYFSGWPDH
 | .| .  | | .    | || | | . .|| .|.  .  . .|.   .. | .|.             | | |...  ..    .||    . ||...
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.........dvllktlellstlgeKkkthtvkhysykgWiek

GAPQEAYPALEMLKFCESYkKNVLVHCSAGVGRTGTLVAIKYGIELLI
 .|..|   |..||      |.. ||||.|.||.   . .      .|
ndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmi
subfamily_PTPRN_pd Subfamily PTPRN 29-184 2.9e-14 47.5 In-house 108-257 (297) alignment 
Range on Protein: 29-184
Range on HMM: 108-257/297.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLKTIDVKTDLKEFTDKkGFtlYtveITNSKKKDapKKTVDILYFSGW
|  ||  . | .. .. |.. |.|..  | . |.|..|. |.  |   .. | .. .  .   ...  .  |  |   . | ....   .||  ..|  |
plastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvr.sf..y...lknlqtse..trtvtqfhflsw

PDHGAPQEAYPALEML-KFCESYKK---NVLVHCSAGVGRTGTLVAIKYGIELLIMPVRQ
|..|.| .| . ||.  |   ||.     ..||||.|.||||. ..|   .. |.  |..
peegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvke
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 25-179 8.1e-14 45.9 In-house 95-240 (439) alignment 
Range on Protein: 25-179
Range on HMM: 95-240/439.0
KDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkkcaeYYSDKvgGVLKFGRYSLKtIDVKTDLKEFTdKKGFTLYtveitNSKKKDAPKKTVDILY
.   ||| |... | .. .....  |.|. .||        |.  .  .   .|  ... .| . .| ...  .|| ..     | . .   ..||  ..
atqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavr.vdrnielpnyv.irgfkvf.....nerdttekertvlqfh

FSGWPDHGAPQEAYPALEMLKFCESYKK-----NVLVHCSAGVGRTGTLVAIKYGIELLI
.  |||.  | .|   |..|.  .| .       |.||||||||||||..|.   .| | 
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk
subfamily_PTPN9_pd Subfamily PTPN9 29-149 1.1e-13 45.9 In-house 93-204 (297) alignment 
Range on Protein: 29-149
Range on HMM: 93-204/297.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSKKKDapKKTVDILYFSGW
| | |.. .| .. ...| . |    .||    ||..|. .. . . .|| .|.....|..       .. ..  ..||.|.|...  ...|    | .|
plkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.......eedykvrvleiknvktee..srkvthfqflsW

PDHGAPQEAYPALEMLKFCES
||.| |..|   |..|.   .
PdyGvPssaaslldvlekvre
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 29-182 1.6e-13 45.5 In-house 99-252 (325) alignment 
Range on Protein: 29-182
Range on HMM: 99-252/325.0
PKKSTCEKHWAVIDQHNVAICVqLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVktdlKEFTDkkgFTLYTVEITNSKKKDapKKTVDILYFSGW
|. .| .  | .. . . .. | .   .......|| |. ...|   .||   .| . .    .|..|   .    ... . || .   ..|  . . .|
PltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrti....eeisd...yvhrvldvkqvkkGe..trsvkqfqlqsw

PDHGAPQEAYPALEMLKFCES----YKK------NVLVHCSAGVGRTGTLVAIKYGIELLIMPV
.| | ..     . .|.  .      .        .||||||||||||.....   .. .|   
ddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviees
subfamily_CG7180_pd Subfamily CG7180 29-178 3.6e-13 43.8 In-house 93-250 (296) alignment 
Range on Protein: 29-178
Range on HMM: 93-250/296.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkKCAEYYSDKVggVLKFGRYSLKTIDVKTdLKEFTDKKgFTLYTV---EITNSKKKDAPKKTVDILYF
|||.| ...| .. ....   | |.   . .. .. .|.  |     ..|   .... .|. . ... .. | |.        . |. .|....|  . .
pkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekq.yanlkirt.fkltkkivalteqekqvkaetRivklfql

SGWPD-HGAPQEAYPALEMLKFCESYKKNV---------LVHCSAGVGRTGTLVAIKYGIELL
  |.  .  |  .   .|...  ......|         .|..| |..|.|  .||   .||.
teWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 28-226 2e-12 41.5 In-house 87-278 (287) alignment 
Range on Protein: 28-226
Range on HMM: 87-278/287.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKTDLKEftdkkgFTLYTVEITNSKKKDApkKTVDILYFSG
 |  .|  . | .. ....|  . .   ||   .|| .|. ..    .. | ||.  .| .    |      ..  .. . . . ..|  . |  | .  
gPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePe......ygvralrlidletrea..rvvkqldlls

WPDHGAPQE----AYPALEMLKFCESYKK-----NVLVHCSAGVGRTGTLVAIkygielLIMPVRQCRYGAVQDESQITYLLLFvTKGLMeKVPVTYLHS
|||....      .  .|.. .. |  ..      ..||...|.||.|.|.|.      |..  |    | |     . .|. .  ..|. . .| .  .
wPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat......lvlvsrledlGrvdvaavvirlrey.raalv.qavvqlrll

FNVLQ-YYH
.. |  ||.
yealvtyyk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 34-172 2e-12 41.8 In-house 65-195 (239) alignment 
Range on Protein: 34-172
Range on HMM: 65-195/239.0
CEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFgRYSLKTIDVktdlkeFTDkkgFTLYTVEItnSKKKDAPKKTVDILYFSGWPDHGA
.   | .. |   .. | |  ..|| .||| .|. |      .. | .|.  .|      |.|   . . |. .  |.  .. .. |   .|. |||.| 
sgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.rvtlrktev......fad...yiirtfvm..sqvgqteeryvyqyhftvwpdkgv

PQEAYPALEMLK----FCESYKKNVLVHCSAGVGRTGTLVAIK
|| |   | . .          .  ..||||||||||... | 
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 34-172 2e-12 41.8 In-house 64-194 (239) alignment 
Range on Protein: 34-172
Range on HMM: 64-194/239.0
CEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFgRYSLKTIDVktdlkeFTDkkgFTLYTVEItnSKKKDAPKKTVDILYFSGWPDHGA
.   | .. |   .. | |  ..|| .||| .|. |      .. | .|.  .|      |.|   . . |. .  |.  .. .. |   .|. |||.| 
sgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.rvtlrktev......fad...yiirtfvm..sqvgqteeryvyqyhftvwpdkgv

PQEAYPALEMLK----FCESYKKNVLVHCSAGVGRTGTLVAIK
|| |   | . .          .  ..||||||||||... | 
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 28-197 4.9e-12 40.1 In-house 92-265 (301) alignment 
Range on Protein: 28-197
Range on HMM: 92-265/301.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTdLKEFTD-------KKGFT-LYTVEITnSKKKDAPKKT
.| |.|    | .| |. ..  | ..   || ..|| .|...      .||  . . .. .. . .|.        ..|.   |.      .|.|   ..
gpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkf.kvksdksswd

VDILYFSGWPDHGAPQEAYPALEMLK-----FCESYKKNVLVHCSAGVGRTGTLVAIKYGIEllimpvrQCRYGAVQDESQIT
|  |    ||..|  .|    |. .           .  |.||||..|.|.|. ...  |.|       ||.   | |  |.|
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglE.......QckaegVVdvfqvt
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 28-172 1.2e-11 38.6 In-house 95-190 (392) alignment 
Range on Protein: 28-172
Range on HMM: 95-190/392.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEekkcaeyysdkvggvlkfgryslktidvktdlkeftdkkgftlytveitnskkKDAPKKTVDILYFSG
 |. .. .  | .. |.||.  . .  . ||.                                                     |   ..||   .|. 
gpnaaslddfwrmvfqenvttiamvtklkegd.....................................................kgddartvaqfhfte

WPDHGAPQEAYPALEMLKFCE----SYKKNVLVHCSAGVGRTGTLVAIK
|||.. |. .   |...|  .    .| . ...|||||||||| ...| 
wPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid
0038934 (Phosphotyrosine protein) phosphatases II 128-203 1.8e-11 39.5 In-house 87-173 (194) alignment 
Range on Protein: 128-203
Range on HMM: 87-173/194.0
WPDHGAPQEAYPALEMLKFC-----ESYKKNVLVHCSAGVGRTGTLVA------IKYGIELLIMPVRQCRYGAVQDESQITYLLLFV
.||.|..      |. |...     |. .. |.||| ||.||||||||       ..  |  |  .|..| ||..  ... .|| ..
fpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 28-175 2.8e-11 37.8 In-house 82-223 (283) alignment 
Range on Protein: 28-175
Range on HMM: 82-223/283.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYslkTIDVKtdlKEfTDKKGFTLYTVEITNSkkkDAPKKT--VDILYF
 | . |    | .. .....  | |  . |....||. |.  .  |  ..| .   |. ..   || | .. |.   . . ..    . |.|  .    .
sPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr..GsedyGef...tvtlr...ke.ttsnsfiikelllrvn...ssakstlllahyqv

SGWPDHGaPQEAYPAL---EMLK--FCESYKKNVLVHCSAGVGRTGTLVAIKYGI
 .| . | .|    .|   . ..    || |  ..||||.|.|||....|.   .
idWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 29-135 9.9e-10 32.7 In-house 84-181 (297) alignment 
Range on Protein: 29-135
Range on HMM: 84-181/297.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDlkEFTdkkgfTLYTVEITNSKKkdAPKKTVDILYFSGW
| ..| . .| .. ...| . | .. . |.  .||| |. . |.. || | . .. .   .|  ||      ...  |..   .  . .. |    | .|
plsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsd..efd.....rviltelqliyr..sesrvvrhvqflsw

PDHGAPQ
|||| | 
pdhGvps
DSPc Dual specificity phosphatase, catalytic domain 92-184 2.4e-09 32.1 Pfam-A 11-105 (133) alignment 
Range on Protein: 92-184
Range on HMM: 11-105/133.0
KEFTDKKGFTLyTVEITNSKKKDAPKKTVDILYFSG----WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVaIKYGIELLIMPVRQ
.....|.|.|| ....|......  .|. .| |..       .    .|   | |... .|. .|.||||| ||. |..||. | | ..   .....
lalleklgitl.vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktknlslne
DSPc Dual specificity phosphatase, catalytic domain 92-184 2.4e-09 32.1 In-house 11-105 (133) alignment 
Range on Protein: 92-184
Range on HMM: 11-105/133.0
KEFTDKKGFTLyTVEITNSKKKDAPKKTVDILYFSG----WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVaIKYGIELLIMPVRQ
.....|.|.|| ....|......  .|. .| |..       .    .|   | |... .|. .|.||||| ||. |..||. | | ..   .....
lalleklgitl.vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktknlslne
0048567 (Phosphotyrosine protein) phosphatases II 119-200 2.4e-09 31.7 In-house 36-132 (157) alignment 
Range on Protein: 119-200
Range on HMM: 36-132/157.0
TVDILYFSGWPDHGaPQE-------AYPALEMLKFCESYKKNVLVHCSAGV---GRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQITYLL
. ...|.. . |.| | .       .. . ..||..|  .| . |||.||    |||.||..       ..  |  | |.|..| | |    .  .|.
ddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasylls
PTPc_motif_SM00404 134-183 6e-09 30.9 In-house 63-111 (140) alignment 
Range on Protein: 134-183
Range on HMM: 63-111/140.0
PQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVaIKYGIELLIMPVR
 ..   .|.... .|. ...||||| ||| |..||. | | ..   . ..
skyldkvldfienaekkggkvlVHCqaGvSRSatli.iaYlmryrqlsla
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 29-176 7.1e-09 29.6 In-house 102-248 (310) alignment 
Range on Protein: 29-176
Range on HMM: 102-248/310.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSdKVGGVLKFGRYSLKTIDVKTDLKEFTDKK-GFTLYTVEITnSKKKDAPKKTVDILYFSG
| . |    | .| |      . ||  .|    ||  |.   .|    .|   .  .   ..  |  .    |    | .   .  .  .  |... .  
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvd.eqpanlkelrvslikwpn

WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIE
||| | |.|   ..    ...  .  ..||||||..|....||.|. |.
wpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkid
subfamily_ptpA1_pd Subfamily ptpA1 29-170 8.2e-09 29.7 In-house 97-248 (418) alignment 
Range on Protein: 29-170
Range on HMM: 97-248/418.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVlKFGRYSLKTIDV---KTDLKEFTDKKGFTLYTVEITNSKKKDApkKTVDILYF
|   |    | .. .  . | | |    |    ||  |. ...||  .|  |      .     .| |  .     . | .|  . . ..  . .    .
plpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.qfsiygngnevfgtysvelveviqdpereiitrnirltfeget..rditqyqy

SGWPDHGAPQEAYPALEMLKF--------CESYKKNV--LVHCSAGVGRTGTLVA
 |||||  |. . |  ..|.           |  .||  .||||||||||||...
egwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_egg_pd Subfamily egg 28-231 8.4e-09 29.5 In-house 90-275 (307) alignment 
Range on Protein: 28-231
Range on HMM: 90-275/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGeeKKCAEYYSDKVGGVLKF--GRYSLKTIDVKTdlKefTDkKGFTLYTVEITNSKkkdapkktVDILYF
 | | | .  | .. | .|   | | | .|   ..|  |.       |..  | . .....|.   |  .|   |..  . .  ..         . .. 
aplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvds..k..ad.plfrvtklklvGgd........deerfl

SGWP-DHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLIMPvRQCRYgAVQDESQitylLLFVTKGLMEKVPVTYLHSFNVLQY
  |  |     . |  |..|.      | |.|..  || ...|||||.  .  |.      ..  |.   .    .|   . |  . .. ||  . .. .
ehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrG.pitks.lvlravv....flrlrrrlsvesvllylfvyrlvlf

YHNQVIS
.  .||.
ffrdvig
subfamily_PTPDC1_pd Subfamily PTPDC1 123-202 8.9e-09 30.0 In-house 85-171 (182) alignment 
Range on Protein: 123-202
Range on HMM: 85-171/182.0
LYFSGWPDHGAPQEaYPALEMLKFCESY--KKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQITYLLLF
 |  ||.|.|..     .|.. |  ..   ...| ||| || |||| |.|       ..  |  |  ||. |  ..|  .|.  .  |
vynfgwkDygvasl.eriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkef
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 122-174 1e-08 29.3 In-house 219-285 (350) alignment 
Range on Protein: 122-174
Range on HMM: 219-285/350.0
ILYFSGWPDH---GAPQEAYPALE------MLKFCESYK-----KNVLVHCSAGVGRTGTLVAIKYG
 |..  |.|      |..  .|||         |.||.      . .|||||||||||||||.. . 
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 117-172 1.3e-08 28.6 In-house 88-148 (440) alignment 
Range on Protein: 117-172
Range on HMM: 88-148/440.0
KKTVDILYFSGWPDHGAPQEAYPALEMLKFC-ESYKK----NVLVHCSAGVGRTGTLVAIK
 .|.   .. ||||.| |. | | |.|..   || .|     .|||||||.|||| ..|. 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavd
PTEN_1 127-170 1.5e-08 29.7 In-house 101-149 (196) alignment 
Range on Protein: 127-170
Range on HMM: 101-149/196.0
GWPDHGAPqEAYPALEMLKFCESY------KKNVLVHCSAGVGRTGTLVA
...|||||      ....| ....      ...||||| ||.||.||.||
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 152-184 3.5e-08 27.2 In-house 266-298 (349) alignment 
Range on Protein: 152-184
Range on HMM: 266-298/349.0
KNVLVHCSAGVGRTGTLVAIKYGIELLIMPVRQ
  .||||||| ||||.|| . . ...|... ..
stllvhcsaGcGrtGvlvtldlllsileplqne
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 29-175 1.1e-07 26.1 In-house 80-216 (267) alignment 
Range on Protein: 29-175
Range on HMM: 80-216/267.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEekkCAEYYSDKVGGVLKFgrySLKTIDvkTDLKEftDKKGFTLYTVEItnsKKKDAPKKTVDILYFSGW
| | |  ... || ...|.. | |    ...      ..  |.|   |.      |..    |..  ... . . |.|.   | |.   . | . |.  |
plkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakky...qdltve..hslek..eendyqiitlel...kfknesahnvtlyyykkw

PDHGAPQEA-YPALEML--KFCESYKKNVLVHCSAGVGRTGTLVAIKYGI
      .    | . .|  .  |   . ..|.||.||||.||.. |.  .
nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsql
subfamily_CDC14_pd Subfamily CDC14 142-193 1.4e-07 25.7 In-house 254-311 (328) alignment 
Range on Protein: 142-193
Range on HMM: 254-311/328.0
EMLKFCESYKKNVLVHCSAGVGRTGTLVAI----KYGIE--LLIMPVRQCRYGAVQDE
..|. .|. . .. ||| ||.||||||.|     .|..     |  .| || | |   
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigp
subfamily_CG42327_pd Subfamily CG42327 29-145 4.4e-07 23.9 In-house 80-188 (319) alignment 
Range on Protein: 29-145
Range on HMM: 80-188/319.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVlKFGRYSlktiDVKTDLKEFTDKKGFTLYTVEITNSKKKDAPKKTvdILYFsGW
. ...  . | .. . .  . |||..  |   |.||||.  | ..      |     |..  ||.   |. . . |. . . .|. . . |    ..  |
sledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld.ntslyG....dilvtlkgrevkdryaistlllkrvdkeesrelt..hywy.kw

PDHGAPQEAYPALEMLK
.. . | |  . . || 
leaevPaeeaaliamll
subfamily_PRL_pd Subfamily PRL 141-199 9.4e-07 23.0 In-house 80-142 (151) alignment 
Range on Protein: 141-199
Range on HMM: 80-142/151.0
LEMLKFCESYKKNVLVHCSAGVGRTGTLVAIK---YGIEL--LIMPVRQCRYGAVQdESQITYL
| . ||.|. |. | ||| ||.||.  |||.     |..    .  .|. | ||.  . |...|
llkekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefirekrrgain.skqlkfl
subfamily_DSP15_pd Subfamily DSP15 106-171 2.9e-06 21.4 In-house 33-98 (151) alignment 
Range on Protein: 106-171
Range on HMM: 33-98/151.0
EITNSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAI
 . ...||  ....  ..  |  |.    .    . |..  | . ..|||||| ||| |  |||..
svhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva
subfamily_PTPN9_pd Subfamily PTPN9 154-178 5e-06 20.8 In-house 226-250 (297) alignment 
Range on Protein: 154-178
Range on HMM: 226-250/297.0
VLVHCSAGVGRTGTLVAIKYGIELL
..||||||.|||||.... . .. |
ivvhcsaGiGrtGtfitldiclsrl