Gene T20B6.1 in Caenorhabditis elegans

Synonym: CELE_T20B6.1, T20B6.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP185_AA protein Get Run
CeleP185_AA_4-217 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 6-220 2.3e-122 402.1 In-house 61-301 (302) alignment
Range on Protein: 6-220
Range on HMM: 61-301/302.0
VDFLNDQVF----------QGPMDGTEDKKDGN-----PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTD
 ||.|..|.          ||||||||.|.. .     |||||.|||||.|.|.||||.||||||||.|||||||||||||||.||||||..||..||||
ndfinanvlkldeikwimaqGpmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktd

LKEFTDKKGFTLYTVEITNSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIEL-----------LI
|.||||||.|.||||||.|.|||.. |||||||.||.|||||||.|||.||..||||||||||||||||||||||||||||||||.|           ..
leeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsiv

MPVRQCRYGAVQDESQITYLLLFVTKGLMEKVPVTYLHSFN
.|||||||||||||.|..||||.||||||||..|.||.||.
lpvrqcryGavqdeqqliylllcvtkglmekagvlylrsfd

0036941 (Phosphotyrosine protein) phosphatases II 28-215 7.4e-46 152.2 In-house 85-285 (297) alignment
Range on Protein: 28-215
Range on HMM: 85-285/297.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDlkeftDKKGFTLYTVEITNSkkKDAPKKTVDILYFSG
 |...|.|..|  . ..|| . | |...|| . .|||.|.....|..|..|........|...     .....||.|.|.|.   .. ...|| .... |
gPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt..gngesrtvthfhytg

WPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGIELLI--------------MPVRQCRYGAVQDESQITYLLLFVTKGL
|||||.|. ... |........       .. |||||||||||.||..|. . ...|                 .|..|.|||| ..|  .|  .. . |
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

MEKVPVTY
. | .. .
kkkltkep

0040438 (Phosphotyrosine protein) phosphatases II 15-218 2.2e-44 147.4 In-house 92-287 (317) alignment
Range on Protein: 15-218
Range on HMM: 92-287/317.0
QGPMdgtedkkdgnpkKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkkKD
|||.            ..|.|..|  . ...| . | |....| . .|||.|...  |..|..|... .......       ..|.||.|.|....  .|
qgPl............pntvedFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl..gd

APKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQITYL
 .. || .... ||||||.|.   . |..|......    .. ||||||||||||||..|. .            .|  .  .|..|.|||| ..|. .|
sesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl

LLFVTKGLMEKVPVTYLHS
  .. . |. |.. .....
ydalleylkrkltlepase

0050432 (Phosphotyrosine protein) phosphatases II 28-207 6.6e-44 145.9 In-house 115-299 (308) alignment
Range on Protein: 28-207
Range on HMM: 115-299/308.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVG-GVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSKKKdaPKKTVDILYFS
 |...|.|..|  . ..|| . | |...|| . .|||.|. ...| |.|..|...........       ....|..|.|.||....  . .|| .... 
gPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdg..esrtvthfhyt

GWPDHGAPQEAYPALEMLKFCESY--KKNVLVHCSAGVGRTGTLVAIKYGIELL-----------IMPVRQCRYGAVQDESQITYLLLFVTKGL
.|||||.|... . |..|......  .....||||||||||||..|. . .|.|           .  .|..|.|.||...|  .|   . . |
nWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

0047943 (Phosphotyrosine protein) phosphatases II 28-203 5.2e-42 139.6 In-house 84-268 (273) alignment
Range on Protein: 28-203
Range on HMM: 84-268/273.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGG-VLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSKKKDapKKTVDILYFS
.|...|.|..|  . ..|| . | |...|| . .||| |.....|. .|..|... ......|       |...|..|.|.||.. ..  ..|| .... 
gPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlgtge..srtvthfhyt

GWPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGIELL-----------IMPVRQCRYGAVQDESQITYLLLFV
||||||.|.   . ||.......       .. |.||||||||||||..|. . ...|           .  .|..|.|.|| ..|. .|  ..
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeal

0045450 (Phosphotyrosine protein) phosphatases II 28-205 5.6e-42 139.9 In-house 114-302 (307) alignment
Range on Protein: 28-205
Range on HMM: 114-302/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkKKDAPKKTVDILYFSG
.|...|.|..|  . ...| . | |...|| . .|||.|..|. |..| .|..  .......       ..|.|..|.|.|.. ... .  || .... |
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......ldgytvrtlevtdl.dgtgesrtvthfhytg

WPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGIELL--------------IMPVRQCRYGAVQDESQITYLLLFVTK
|||||.|.   ..|.... ...       .. ||||||||||||||..|. . ...|              .  .|..|.|||| ..|. .|  .. .
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0046845 (Phosphotyrosine protein) phosphatases II 28-208 7.1e-42 139.1 In-house 84-275 (284) alignment
Range on Protein: 28-208
Range on HMM: 84-275/284.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkKKDAPKKTVDILYFSG
 |...|.|..| .. ..|| . | |...|| . .||| |.... |.||..|... .......       |...|..|.|.||  . . . .|| .... .
gPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnl.gytgesrtvthfhyts

WPDHGAPQEAYPALEMLKFCESY------KKNVLVHCSAGVGRTGTLVAIKYGIEL--------------LIMPVRQCRYGAVQDESQITYLLLFVTKGL
|||||.|... . ||.|......      .. ..||||||||||||..|. . .|.              ..  .|..|.|.|| ..|. ..  ..   |
wpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

M
.
k

0051299 (Phosphotyrosine protein) phosphatases II 28-203 1.2e-40 135.2 In-house 99-282 (288) alignment
Range on Protein: 28-203
Range on HMM: 99-282/288.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNS--KKKDAPKKTVDILYF
 |...|.|..|  . ..|| . | |...|| . .||| |...  ||.|..|... .......       ....|..|.|.||    ..|  ..|| ....
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhy

SGWPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYGIEL-----------LIMPVRQCRYGAVQDESQITYLLLFV
 .|||||.|. . . |..|... ..    .. |.||||||||||||..|. . .|.           ..  .|..|.|.|| ..|. ..   .
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal

Y_phosphatase Protein-tyrosine phosphatase 29-200 4e-40 133.0 Pfam-A 50-230 (235) alignment
Range on Protein: 29-200
Range on HMM: 50-230/235.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIdvktdLKEFTDKKGFTLYTVEITNSKKKDAPKKTvDILYFSGW
| |||.|..|... |..| . |.|.| .| ...|||.|.... .. |..|......       || .|.|..||...|....|........   | . .|
PlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnW

PDHGAPQEAYPALEMLKFCESYK----KNVLVHCSAGVGRTGTLVAIKYGIELLIM-----------PVRQCRYGAVQDESQITYLL
||||.|... . |.... .|..|    ..|.||||||||||||.||... .| |              .|..| |.||...|  .| 
pdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

Y_phosphatase Protein-tyrosine phosphatase 29-200 4e-40 133.0 In-house 50-230 (235) alignment
Range on Protein: 29-200
Range on HMM: 50-230/235.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIdvktdLKEFTDKKGFTLYTVEITNSKKKDAPKKTvDILYFSGW
| |||.|..|... |..| . |.|.| .| ...|||.|.... .. |..|......       || .|.|..||...|....|........   | . .|
PlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkeesekrev.kqlhytnW

PDHGAPQEAYPALEMLKFCESYK----KNVLVHCSAGVGRTGTLVAIKYGIELLIM-----------PVRQCRYGAVQDESQITYLL
||||.|... . |.... .|..|    ..|.||||||||||||.||... .| |              .|..| |.||...|  .| 
pdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly

0039614 (Phosphotyrosine protein) phosphatases II 28-210 6.9e-40 132.7 In-house 108-292 (297) alignment
Range on Protein: 28-210
Range on HMM: 108-292/297.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkKCAEYYSDKVGgvlKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNskkKDAPkKTVDILYFSG
 | ..|.|..|  . ...| . | |...|| .  |||.|.....|   ..|... ....|..       ..|.|..| |.||   .. . .||  . . |
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn...nges.rtvthfqytg

WPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYGI-----------ELLIMPVRQCRYGAVQDESQITYLLLFVTKGLMEK
|||||.|. .   ||.|.....       .. ||||||||||||||..|. . .           .  .  .|..|.|||| .||. .|  .. . |. |
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk





0040439 (Phosphotyrosine protein) phosphatases II 15-205 3.4e-39 130.3 In-house 60-244 (249) alignment
Range on Protein: 15-205
Range on HMM: 60-244/249.0
QGPMDGtedkkdgnpkksTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSkkKD
|||...            |.|..|  . .... . | |.|.|| . .|||.|...  ||.|..|... ....|..       |...|..|.|.||.  .|
qgPlpe............tvedfwrmlwelgitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl..yd

APKKTVDILYFSGWPDHGAPQEAYPALEMLKFCES------YKKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQIT
 .. ||  ... .|||||.|.   ..|.... ...       .. ||||||||||||||..|. .            .|  .  .|..|.|||| ..|. 
gesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyr

YLLLFVTK
.|. .. .
flyealle

0045098 (Phosphotyrosine protein) phosphatases II 28-207 6.9e-39 129.3 In-house 71-272 (278) alignment
Range on Protein: 28-207
Range on HMM: 71-272/278.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTDlkeftDKKGFTLYTVEITNSKKKDAPKKTVDILYFSG
 |..||....|  . .... . | |...||.. .|||.|. .  ||.| .|...........      |.   . ..|. ......| .. .| .|.. .
gPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylp

WPDHGAPQEA--YPALEMLKFCES-----------------YKKNVLVHCSAGVGRTGTLVAIKYGIEL---------LIMPVRQCRYG-AVQDESQITY
|||||.| .    . ||.|.|...                  .. |||||||||||||||||. . .||          .  .|..| | ||| ..|. .
wpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrf

LLLFVTKGL
|  |. . |
lyefllell

0043336 (Phosphotyrosine protein) phosphatases II 28-203 1.6e-38 128.2 In-house 95-273 (278) alignment
Range on Protein: 28-203
Range on HMM: 95-273/278.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSdkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNskKKDAPKKTVDILYFSG
 | ..|.|..|  . ...| . | |...|| . .|||.|..   ||.|..|... .......       ....|..| |.||  ..| ...|| .... |
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn..lgdgesrtvthyhylg

WPDHGAPQEAYPALEMLKFCES----YKKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQITYLLLFV
|||||.|    . |..||.  .     .. ||||||||||||||..|. .            .|  .  .|..|.|||| .||. .|  ..
wpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

0042113 (Phosphotyrosine protein) phosphatases II 28-203 8.8e-38 125.5 In-house 59-239 (245) alignment
Range on Protein: 28-203
Range on HMM: 59-239/245.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNskKKDAPKKTVDILYFSG
 | ..|.|..|  . .... . | |....| . .|||.|...  |..|..|... .......       ....|..|.|.||  ..| ....|  ... .
gPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtn..lgddesrevihyhylp

WPDHGAPQEAYPALEMLKFCES-----YKKNVLVHCSAGVGRTGTLVAIKYG-----------IELLIMPVRQCRYGAVQDESQITYLLLFV
|||||.|      |..|.|...      .. ||||||||||||||..|. .            .|  .  .|..|.|||| .||. .|  ..
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal

0037934 (Phosphotyrosine protein) phosphatases II 28-203 2.1e-35 117.9 In-house 51-238 (243) alignment
Range on Protein: 28-203
Range on HMM: 51-238/243.0
NPKKSTCEK----HWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSdkvGGVlKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNsKKKDAPKKTVDIL
 | ..|.|     .|  . .... . | |...|| . .|||.|..   |.|  .|... .......       ....|..|....| .. | ....|  .
gPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...gev.tygdftvtllseeh.......lddytvrtlllen.ldlddltrlvihy

YFSGWPDHGAPQEAYPALEMLKFCESY------------KKNVLVHCSAGVGRTGTLVAIKYGIE-------LLIMPVRQCRYG-AVQDESQITYLLLFV
.. .|||||.|..  . |..|... ..            .. |||||||||||||||.|. . ..         .  .|..| | ||| .||. .|  ..
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal





DSPc_SM00195 29-179 6.8e-35 116.0 In-house 77-223 (263) alignment
Range on Protein: 29-179
Range on HMM: 77-223/263.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLkeftdkKGFTLYTVEITNSKKkdAPKKTVDILYFSGW
|..||.|..| .. ...| | | |....| ...||..|. .. ||  .||..|.|...|...       . ..|.|.|.|. .|    ...|  . . .|
PlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk..eetrkvtqyqyknW

PDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIELLI
||||.|... . ||.|..... |.     ..||||||||||||.|.|.. .. | 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle

PTPc_SM00194 29-179 6.8e-35 116.0 In-house 77-223 (263) alignment
Range on Protein: 29-179
Range on HMM: 77-223/263.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLkeftdkKGFTLYTVEITNSKKkdAPKKTVDILYFSGW
|..||.|..| .. ...| | | |....| ...||..|. .. ||  .||..|.|...|...       . ..|.|.|.|. .|    ...|  . . .|
PlpstvedFWrmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk..eetrkvtqyqyknW

PDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIELLI
||||.|... . ||.|..... |.     ..||||||||||||.|.|.. .. | 
pdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskle

subfamily_PTPN12_pd Subfamily PTPN12 7-179 4.2e-30 99.6 In-house 69-235 (290) alignment
Range on Protein: 7-179
Range on HMM: 69-235/290.0
DFLNDQVFQGPMDGTEDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDvktdlKEFTdKKGFTLYTVE
|..| .. .|. . .|      |   | . .| .|...|| | | .|  || . |||. |......  |.|| .......     .. . ...|.. |..
dYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.....ekav.dddflirtLk

ITNSKKkdapKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIELLI
....|.    ...|  . .  ||||| |. | . ||...  .....     ..||||||||||||..|| |  ||| 
veaqke....srkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellk

0041856 (Phosphotyrosine protein) phosphatases II 5-209 3.3e-27 90.6 In-house 18-173 (182) alignment
Range on Protein: 5-209
Range on HMM: 18-173/182.0
TVDFLNDQVFQGPMDGTEDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCsfvegeekkCAEYYSdkvggvlkfgryslktidvktdlkeftdkkgftlyt
  |. |. .. |.. .|.      | .||.....  . .... . | |.         .  |.                                     
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp....................................

veitnskkkDAPKKTVDILYFSGWPDHGAPQeAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQITY
         .  ....  ... .|||||.|   . .|.... ... ...|||||||||||||||||.      ....|  .  ||..| |.|. ..|. .
.........ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyff

LLLFVTKGLME
| |..   |. 
lqlallellll

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 28-176 5.3e-27 89.8 In-house 96-241 (305) alignment
Range on Protein: 28-176
Range on HMM: 96-241/305.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKtidvktdLKEFTDKKGFTLYTVEITNSKKkDAPKKTVDILYFSG
 | |.| .  | .| .  |   |.|.  |||...||  |. .... . .||..|..       ||...  ....   ..|.. .. |  ..||  . .  
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsve.......lksektasdyieRklkisiede.dkesrtvlqyqltd

WPDHGAPQEAYPALEMLKFCE-SYKK----NVLVHCSAGVGRTGTLVAIKYGIE
||||| ||.|   |...|  . ..||     .||||||||||||. .|..  .|
WPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdiale

subfamily_PTPRD_pd Subfamily PTPRD 29-176 4.5e-26 86.6 In-house 99-239 (564) alignment
Range on Protein: 29-176
Range on HMM: 99-239/564.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGgVLKFGRYSLktidvktDLKEFTDKKGFTLYTVEITNSKKKDApkKTVDILYFSGW
|...|.|  |  . ..|... | | . .| ...||..|. .| |   ..|..         .|.| .... ... | .....|....  ..|   .|  |
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltV.......tleeeeeladyeirtfklkkkksses..reVrqFhFtsW

PDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIE
||||.|..| . |.... ......     ..|||||||||||| ..|.. .|
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamle

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 29-195 1e-25 85.3 In-house 83-258 (285) alignment
Range on Protein: 29-195
Range on HMM: 83-258/285.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLKeftdkKGFTLYTVEITNSKKKDAPKKTVDILYFSGW
|   |    | .| | ..|  . ||...||  .||| || .|.| |.|||.| .   ..| .        |  | .. ..|..   .    .. .    |
plpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeai.....agtilnaltvintedasseplymnhvqvpww

PDHGAPQEAYPALEMLKFCE---SYKKNVLVHCSAGVGRTGTLVAIKYG---------IELL--IMPVRQCRYGAVQDESQ
||. ||..| | .|. |. .     .| . |||||||||| |.| | |          ||.|  .  .|  |. |||   |
pdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmq

0051429 (Phosphotyrosine protein) phosphatases II 28-209 1.4e-25 85.9 In-house 29-227 (272) alignment
Range on Protein: 28-209
Range on HMM: 29-227/272.0
NPKKSTCEKHWAViDQHNVAICVQLCSFVEGEEKKCAEYYS----------DKVGGVLKFGRYSLKTIDVKTDLKeftdkkgFTLYTVEITNSKKKDAPk
.| . |..  |.   ....   | |.| .| .  ||  |            | .     .|....... ... |        ..|.. ..|.  . ... 
gplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld.......yilrellltlllsagea.

KTVDILYFSGWPDHGAPQEAypALEMLKFCESyKKNVLVHCSAGVGRTGTLVAIKYG-------------------IELLIMPVRQCRYGAVQDESQITY
 .| .|.. .|||||.||||   ||.|... . ...||||||||..||||.||. .                    .|  .  .|..| ||||.| |. .
revmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylf

LLLFVTKGLME
|. .. . |..
lyeallellrs

0036282 (Phosphotyrosine protein) phosphatases II 29-201 2.7e-25 84.5 In-house 27-164 (174) alignment
Range on Protein: 29-201
Range on HMM: 27-164/174.0
PkkstcekHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvggvlkfgryslktidvktdlkeftdkkgftlytveitnskKKDAPKKTVDILYFSGW
.       .|. . .... . |.|.. .| .  ||  |...                                          ... .....  ... .|
a.......fwemlkelgittvvmlleekelglykcinywpe..........................................lredlerlgiqylylpw

PDHGAPQEAYpALEMLKFCESY-----KKNVLVHCSAGVGRTGTLVAIKYGIELLI-------MPVRQCR---YGAVQDESQITYLLL
||||.|  .   ||..||.|..     .. |||||||||||||||||. . . .|.         ||..|    |.|| .||. .|  
pDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy

0049260 (Phosphotyrosine protein) phosphatases II 29-200 3.8e-25 83.8 In-house 17-143 (152) alignment
Range on Protein: 29-200
Range on HMM: 17-143/152.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYsdkvggvlkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkktvdILYFSGW
|   |....|  . .... . | |....|  . ||..|.                                                        ..  |
pgpntladfwrmlkelgittivmltellelgklkceqyi......................................................qylhlpw

PDHGAPQEAYPALEMLKFC----ESYKKNVLVHCSAGVGRTGTLVAI-----KYGIELLIMPVRQCRYGAVQDESQITYLL
||||.|. .   |..|.|.    .. ...|||||||||||||||||.     .. .|  .  ||..| |||. ..|. .|.
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylmllgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 28-173 5e-25 82.8 In-house 97-236 (301) alignment
Range on Protein: 28-173
Range on HMM: 97-236/301.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLKEFTDKKgftlyTVEITNSKKKDApKKTVDILYFSG
 | |.|.|  ||.. |..|   | |. .|| .|.||.||.. |..  |. ||...|. . .. |.. . |.     |.|...| .| |  .||    .| 
gPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskr.....tlevedstgkfa.trtvthyqyse

WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKY
|.|.| |.      .....    .| ..||||||.||. .... .|
wtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigtey

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 28-199 2.2e-24 81.0 In-house 89-269 (307) alignment
Range on Protein: 28-199
Range on HMM: 89-269/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSlKTIDVKT-DLKEFT-DKKGFTLYTVEITNSKKkdapKKTVDILYF
 |...|  . ||.. |..|   . ||  .|  . || .|.  . |  | ||  . .|| |.    |... |..   . |...  ..|     .|.. | .
gplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeap.ntisvanlgakklapdedlinvttlkvdwaqk....srtiqhlqw

SGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIE------------LLIMPVRQCRYGAVQDESQITYL
. |||.|.||    |...|.  .  .  |.|||||||||.||.||| .  .             |.  .|. |  |.|.| |  ||
enwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 29-179 2.5e-24 80.4 In-house 102-244 (290) alignment
Range on Protein: 29-179
Range on HMM: 102-244/290.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTiDVKTDLKEFTDKKGFTLYTVEitNSKkkdapKKTVDILYFSGW
. |.|    | .. |..||  | ||  .|    ||..|| .| | || || ...     ..|  . . || ...  ..  . |     .. .  |    |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlc.seeddkdaniikktlsvrdkd..sGk.....ehklkhlkiksw

PDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLI
||.  .. .   | .|.        | ||||||.|||||.|||. |...|.
pdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqill

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 29-208 3.4e-24 80.4 In-house 90-272 (288) alignment
Range on Protein: 29-208
Range on HMM: 90-272/288.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYslktidvKTDLKEFTDKKGFTLYTVEITNSKKKDAPKkTVDILYFSGW
| ..| |. | .. . .|   | || ..|   .| |||.  |.|   ..||.        |. |.  .    ..    . .||. . ..  | ||..  |
PlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrl.......ctvvkkkradidklvkvsllriskegeekv.ivkilhlleW

PDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAI-----------KYGIELLIMPVRQCRYGAVQDESQITYLLLFVTKGLM
.|.| |..  . | .|.  .|..| ..||.||||||||||. |             ||. |.   |. |. |.| | |  |.   | . |.
dddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleell

0046846 (Phosphotyrosine protein) phosphatases II 27-205 5e-24 80.4 In-house 29-171 (176) alignment
Range on Protein: 27-205
Range on HMM: 29-171/176.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvggV----LkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkktvdI
  |  .|... .. . .... . | |.. || .  ||. |...    .    .                                               
qgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi..............................................q

LYFSGWPDHGAPQEaYPALEMLKFCESYK---KNVLVHCSAGVGRTGTLVAI-------KYGIELLIMPVRQCRY-GAVQDESQITYLLLFVTK
 .. .|||||.|.     ||.|.|....    ..||||||||.||||||||.        . .|  .  ||..|  |||| ..|. .|  |. .
ylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

0043147 (Phosphotyrosine protein) phosphatases II 29-202 6e-24 80.1 In-house 28-156 (172) alignment
Range on Protein: 29-202
Range on HMM: 28-156/172.0
PKKSTCEKHWAVIDQHNVAICVQLCSFvegeekkcaeyysdkvggvlkfgryslktidvktdlkeftdkkgftlytveitnSKKKDAPKKTVDILYFSGW
|  .|....|. . .... . | |...                                                       . ..  ....  ... .|
plrntladfwrmlkelgithivnltel......................................................lydpellerlgiqylylpw

PDHGAPqEAYPALEMLKFCES-----YKKNVLVHCSAGVGRTGTLVAIKY-----GIELLIMPVRQCRYGAVQDESQITYLLLF
||||.|  .   ||.|.|...      .. |||||||||||||||||. .      .|  .  ||..| |||| .||. .|. |
pDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyf

0044763 (Phosphotyrosine protein) phosphatases II 35-206 1.1e-22 76.0 In-house 38-170 (178) alignment
Range on Protein: 35-206
Range on HMM: 38-170/178.0
EKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGgvlkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkktVDILYFsGWPDHGAP
..... . ....   | |.. .|.   || .|. .. |                                               .  |.. ..||||.|
addlellkelgithivnlteelelgflkcdpywpeeag...............................................iqylhi.pipDhgvp

QEAYPALEMLKFCE----SYKKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYgAVQDESQITYLLLFVTKG
.     ||...|.|    . ...|||||||||||.|||||.      .. .|  |  ||..|  .|. ..|. .|..|  . 
dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 29-177 1.2e-22 75.3 In-house 81-227 (274) alignment
Range on Protein: 29-177
Range on HMM: 81-227/274.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKfGRYslktIDVKTDLKEFTDKKGFTLYTVEITNSKKkdapKKTVDILYFSGW
|  .| .  | .| |..| . | |  . | .|.|||.|. |. .  .. .||    .||.   .. ........ .. . ....    ...|   ... |
PlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis.ery....gdveikvekiverndysvrklvlkyler....ersvkhywytdW

PDHGAPQEAYPALEMLKFCESYKK-------NVLVHCSAGVGRTGTLVAIKYGIEL
||| .|..| . |....  |. ..        |.||||||.||||  .||. ..  
PdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrq

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 29-179 2.6e-22 74.0 In-house 96-247 (305) alignment
Range on Protein: 29-179
Range on HMM: 96-247/305.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKtIDVKTDL---KEFTDKKGFTLYTVEITNSKKKDAPKKTvDILYF
| . ||   | .  |..|     || ..|   |||.||.. | . ||.|     | | || .     .|...   ..   ...        .|.    ..
plektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqk.isvkfessvtlkfrkdakakvtetvlviegpgekarkv.thyhw

SGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLI
  ||| | |      ||.|. . . |  . ||||||.||||..| ..| .. |.
idwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqll

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 28-172 2.9e-22 73.4 In-house 93-230 (515) alignment
Range on Protein: 28-172
Range on HMM: 93-230/515.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDlkefTdkkGFTLYTVEITnsKKKDapKKTVDILYFSG
 |.|.. .  | .. |.||.  . .    ||.  ||..|. || |  .||| ...... ....    |   | .  .....  | .|   .||    | .
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac....t...ggikrkltvl..kgdd..srtvtqfhfte

WPDHGAPQEAYPALEMLKFCES----YKKNVLVHCSAGVGRTGTLVAIK
|||.|.|...   | ..|   .    |.  ...|||||||||| ...|.
WPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

subfamily_PTPN3_pd Subfamily PTPN3 29-176 4.3e-22 73.3 In-house 92-233 (280) alignment
Range on Protein: 29-176
Range on HMM: 92-233/280.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkVGGVLKFGRYSLKTIDVktdlkefTDKKGFTLYTVEITNSKKKDapKKTVDILYFSGW
| ..|... | .. .... . | | . ||   .|| .|. .  .  |..|..|.|             .| . |  . ......|.  ....  | .  |
PlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkceke.......detksyvlrelvlkdketke..erkilqlqylaW

PDHGAPQEAYPALEMLKFCESYK----KNVLVHCSAGVGRTGTLVAIKYGIE
|||| |...   ||...  ....    . |.||||||.|||| |....  . 
pdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletala

subfamily_PTPRB_pd Subfamily PTPRB 29-172 5.4e-22 73.2 In-house 102-239 (293) alignment
Range on Protein: 29-172
Range on HMM: 102-239/293.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvggvlkfgRYSLKTIDVKTDLKEFTDKKGFTLYTVEITNskkkDAPKKTVDILYFSGW
|  .| .. | .. .... | | |   ||.  .|| ||. ..        . .    |.| .|.. .... ... ...|..    .  ...|  . |  |
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPad........eepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsW

PDHGAPQEAYPALEMLKFCESYK------KNVLVHCSAGVGRTGTLVAIK
|||| |... . |....  ....      . ..||||||||||||..|..
pdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfiald

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 29-181 5.8e-22 73.0 In-house 72-227 (270) alignment
Range on Protein: 29-181
Range on HMM: 72-227/270.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFgryslKTIDVKTDLKEFTDKKGFTLYTVEITnskKKDAPKKTVdILYFSGW
|...| ...| .| ...|   | .  ..|   |||. |.. ...  .|.     .. ..|.   . . ..|. |  ....   .|   .. |   ..  |
PlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkl.....edgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntW

PDHGAPQEAY------PALEMLKFC----ESYKKN--VLVHCSAGVGRTGTLVAIKYGIELLIMP
||||.|.|.         |.||.      .. .|.  .||||||||||||||.|. ....|| . 
pdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeet

subfamily_PTPRA_pd Subfamily PTPRA 28-175 9.7e-22 72.3 In-house 108-252 (330) alignment
Range on Protein: 28-175
Range on HMM: 108-252/330.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLKtIDVKTDLKEFTDKKgFTLYtvEItNSKKKDAPKKTVDILYFSG
 ||. | |  | .| ... |  | |  . | .|.||| |. |.  |.. .|   .. .. .| |...| .| | .   .. . .... ... |  ..| .
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirve.vedetvlvdytvrk.flvq..ql.pdatrekksrlvrqfhfts

WPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYGI
||| | | |.   |..||  ..        . ||||||||||||.....  .
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavl

subfamily_PTPRG_pd Subfamily PTPRG 25-172 1.3e-21 71.4 In-house 95-241 (563) alignment
Range on Protein: 25-172
Range on HMM: 95-241/563.0
KDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDkvGGVLKFGRYSLKTIDVKTdlKEFTDKKGFTLYTVEITNSKKKdAPKKTVDILY
   .| |.|..  | .| ..|||| | .  .|| . .||  |.     .....|  ... |. ..  .    .. ...  ... . |..   .|.|    
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeev..lalytvrtlviknlklkkkkqc.dteklvrqyh

FSGWPDHGAPQEAYPALEMLKFCESYKKN----VLVHCSAGVGRTGTLVAIK
.. |||||.|. . | | . |  .  .|.    ..||||||||||||.....
ytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld

subfamily_PTPN6_pd Subfamily PTPN6 31-187 1.3e-21 71.9 In-house 108-277 (306) alignment
Range on Protein: 31-187
Range on HMM: 108-277/306.0
KSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLkFGRYSLKTIDVKtdlkeftDKKGFTLYTVEITNSKKKdAPKKTVDILYFSGWPD
..| .  | .. | |  . | .   ||  ..||| |. |.      .|..|..... |       ... ..| .. ... |||   ...|  . |  |||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek.......sladYilRelsvskkkkk.keerevfqyhfksWPd

HGAPQEAYPALEMLKFCESYKKN--------VLVHCSAGVGRTGTLVAIKY--------------GIELLIMPVRQCRY
|| |.. .  |..|.  .. ...        ..||||||.|||||.. |                 |. |.. ||. | 
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrs

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 29-176 1.8e-21 71.3 In-house 99-241 (290) alignment
Range on Protein: 29-176
Range on HMM: 99-241/290.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLKTidvktdLKEFTDKkGFTLYTVEITNSKKKdAPKKTVDILYFSGW
| ..|  . | .|.|..|.| | |.. .| ...||  |..|.  .. ..| .|.|       |.| | . ...  ..|..|.... ..|..|  . .. |
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds..dtkaygefsikl......lneetln.eyierklevknknsa.gakqsvtqyqitnw

PDHGA---PQEAYPALE-MLK-FCESYKKNVLVHCSAGVGRTGTLVAIKYGIE
...|    ||    ..| | |    . .. ..||||..|||.....|.. .|.
dstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattin

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 26-176 2.1e-21 71.2 In-house 95-237 (288) alignment
Range on Protein: 26-176
Range on HMM: 95-237/288.0
DGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKtdlkeftDKKGFTLYTVEITnskkKDAPKKTVDILYF
   |  .| .. | .. ....   | | ..|||...|| ||. |. .   ..|   .. ...|       ... |.| ....     |.  . ..  . .
tqgPladtvndfWelvyenktstivmltelveggktkCeeYWPda.dkpknyGsvtvtlvesk.......eledfvlrkllle....kkkteleitqyqy

SGWPDHGAPQEAYPALEMLKFCESY----KKNVLVHCSAGVGRTGTLVAIKYGIE
 .||||| |. . | ||.|.  .       ....|||||||||||| .|..  |.
laWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalid

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 28-175 2.4e-21 70.9 In-house 94-234 (315) alignment
Range on Protein: 28-175
Range on HMM: 94-234/315.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDLKEFTDKkgftlytVEITNSKKkdapKKTVDILYFSG
 |.|.. .  | .. |..|.  | .    ||.  ||. |. |. .   .|| ..........|    . |       . . .|..    ..||    | .
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvark.......lvtrksee....srtvtqfqfte

WPDHGAPQEAYPALEMLKFCES----YKKNVLVHCSAGVGRTGTLVAIKYGI
|||.|.....   |...|   .    .. ..|||||||||||| ...|.  .
wPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevv

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 28-176 4.1e-21 70.2 In-house 93-236 (287) alignment
Range on Protein: 28-176
Range on HMM: 93-236/287.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGgvLKFGRYSLKTIDVKtdlkeftDKKGFTLYTVEITNSKkKDAPKKTVDILYFSG
 |  .|  . | .||..|| . | ||   | .|..| .|....    . .| |... .. .        ..|..  ..|..|.. |...|..|    .  
sPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.......vnagyierklevknkn.kagdkqqvkqyqitn

WPDHGAPQE-AYPALEMLKFCE----SYKKNVLVHCSAGVGRTGTLVAIKYGIE
|...|  .| .   | . .       . .  ..||||..|||.....|.  .|.
WdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattin

subfamily_PTPN13_pd Subfamily PTPN13 29-177 4.1e-21 70.5 In-house 85-228 (273) alignment
Range on Protein: 29-177
Range on HMM: 85-228/273.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRyslkTidVKTDLKEFTDKKGFTLYTVEITNSKKKDApkKTVDILYFSGW
|   |..  | .. . .. . . . . .|... ||  |. .. .  ||          .. .| . ....||.. ......|. ...  . |  | |  |
PlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsn....r..levellkvqkldgfvvralavkdsesges..revahlnfvkw

PDHGAPQEAYPALEMLKFCESYKK---NVLVHCSAGVGRTGTLVAIKYGIEL
|||| |..| . |....   . ..    ..||||||.||.|||..|.  ..|
PdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlgl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 29-173 6e-21 69.8 In-house 92-230 (281) alignment
Range on Protein: 29-173
Range on HMM: 92-230/281.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGgvlkfgrySLKTIDVKTDLKEFTDKKGFTLYTVEItnsKKKDAPKKTVDILYFSGW
|  ..... | .. ...| . | .   .|..  ||  |. |.          .||  ||.   .. ..|. .   ....   .........|  | .  |
PvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddns........elkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaW

PDHGAPQEAYPALEMLKFCES---YK--KNVLVHCSAGVGRTGTLVAIKY
||||.|...   ||  |  ..    |    ...||||||||||| .|.  
PdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDr

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 28-192 6.7e-21 69.3 In-house 89-246 (312) alignment
Range on Protein: 28-192
Range on HMM: 89-246/312.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVlKFGR---YSLKTIDVKTDLKEfTDKKGFTLYTVEItnskKKDAPKKTVDILY
 | ..|| . | .      .  . ||.|||   .|||.| || || | ..     |.    ...   |   ||    .  | .    |    .  ..   
gplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfv.dledhrvyteycteieiggks.kdkithrvlkvvv....katgqesklnhyq

FSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIkygiELLIMPVRQCRYGAVQD
.. ||||| |.    || .|      || |. ||||||||||||. |    | .|  .|. |   |.|
waswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlali....esmiaalrhprkqnvkd

0048076 (Phosphotyrosine protein) phosphatases II 96-204 2e-20 68.4 In-house 27-140 (145) alignment
Range on Protein: 96-204
Range on HMM: 27-140/145.0
DKKGFTLYTVeitnSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESY---KKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCR
| .  |....    .  .. .....  ... .|||||.|. .   ||.|.|.|..   ...|||||||||||||||||.      .. .|  .  ||..|
dlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqr

YGAVQDESQITYLLLFVT
 |||. ..|. .|..|..
pgavpnpgqlrflyefel

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 29-178 3.3e-20 66.9 In-house 104-248 (305) alignment
Range on Protein: 29-178
Range on HMM: 104-248/305.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGrySLKTIDVKTDLKEFTDKKGFTLYTVEITNSKKKdapKKTVDILYFSGW
|   | .. | .. |..|   | ||  ||    |||.|.    |  |..   |   ..  .  | .       . ....| | ..   | .|  | .. |
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk..sgivvenvsgskpmerdaeiqitllnltysgdq...kmsvrhlqwtew

PDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELL
|| | |     .||.|      |  ..||||||.|||||.|||.| .| .
pdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyileki

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 28-176 3.7e-20 67.2 In-house 98-241 (319) alignment
Range on Protein: 28-176
Range on HMM: 98-241/319.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVggVLKFGRYSLKTiDVKTdlkeftDKKGFTLYTVEItNSKKKDAPKKTVDILYFSG
 |.. | |  | .. .... | | |.  ||  . |. .|....   . ..||. ..  . .        ....    ... | |. .   ..|   ..  
aPlentiedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtl.eeee......eledyiirklkl.nkkssevetRevkhfqyte

WPDHGAPQEAYPALEMLKFCESYKK-----NVLVHCSAGVGRTGTLVAIKYGIE
||||. |..|   |..||  .  ..      . |||||||||||| ....  .|
WpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamle

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 28-173 4.4e-20 67.1 In-house 106-245 (298) alignment
Range on Protein: 28-173
Range on HMM: 106-245/298.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLktidvktDLKEFTDKKGFTLYTVEITNSKKKdaPKKTVDILYFSG
.| ..| |  | .. .....  | | . .| .. |. .|. |.  |  ..|. ..       .|..  ..  ..  .......|..   ...|  | |. 
aPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv.......sllskeefadlivrklkvskkkee..kerevrqlhfts

WPDHGAPQEAYPALEMLKFCESYK-----KNVLVHCSAGVGRTGTLVAIKY
|||.|.|..|   |..|.  . ..     | |.|.|||||||.|| .||. 
WpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaids

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 29-173 8.4e-20 66.3 In-house 112-246 (319) alignment
Range on Protein: 29-173
Range on HMM: 112-246/319.0
PKKSTCEKHWAVIDQHNVAICVQLCsfvegeEKKCAEYYSDKvgGVLKFGRYSLKTiDVKTDLKEftdkkgFTLYTVEITNS-KKKDapKKTVDILYFSG
|.. | .  | .| ..|..  | |       ..||..|.  |  .| | .|. .|  |. .. .|      ...  .|...  |.||  .. .   .| |
PldntladfWrmiweyncstivllt......kdkcsqywplk..ivikeerfkvkv.dsveetae......yvvrdielsedgkekd..irkitqfhflG

WPDHGAPQEAYPALEMLKF------CESYKKNVLVHCSAGVGRTGTLVAIKY
|||.| |. . . . ..|        |  ..|..|||||||||||. .... 
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldv

0048179 (Phosphotyrosine protein) phosphatases II 105-202 1.3e-19 65.8 In-house 34-140 (144) alignment
Range on Protein: 105-202
Range on HMM: 34-140/144.0
VEITNSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESY---KKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQ
. .|..  .. .....  ... .|||||.|. .   ||.|.|.|..   ...|||||||||||||||||.      .. .|  .  ||..|.|||. ..|
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnpgq

ITYLLLF
. .||..
lrfLley

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 7-176 1.4e-19 65.3 In-house 75-238 (318) alignment
Range on Protein: 7-176
Range on HMM: 75-238/318.0
DFLNDQVFQGPMDGTEDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGryslkTIDVktDLKEFTDKKGFTLYTVE
|..| .  .| .   .      |   |.|  | .. . | |. | |   .|   .|.. |. .|  |  ..|     .. |  .||| .. . ..| ...
DyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPsk..gsrsyg.....klvv..elkeevelsdyvlrefk

ITNSKKKDapKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYK-----KNVLVHCSAGVGRTGTLVAIKYGIE
.|......  ...|    .  |||.| |...   |....  ....     . ..|||||||||||. .|..  .|
vtrteeee..srqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 29-173 1.6e-19 65.5 In-house 76-210 (284) alignment
Range on Protein: 29-173
Range on HMM: 76-210/284.0
PKKSTCEKHWAVIDQHNVAICVQLCsfvegeEKKCAEYYSDKvgGVLKFGRYSLKTIDVkTDLKEftdkkgFTLYTVEITNS-KKKDapKKTVDILYFSG
|.. | .  | .| ..|..  | |       ..||..|.  |  .| | .|. .|   | .. .|      ...  .|...  |.||  ....   .| |
PldntladfWrmiweyncstivllt......kdkcsqywplk..ivikeerfkvkvdsv.eesee......yvvrdielsedgkekd..irkirqfhflg

WPDHGAPQEAYPALEMLKF------CESYKKNVLVHCSAGVGRTGTLVAIKY
|||.| |. . . . ..|        |  ..|..|||||||||||. .... 
wpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 25-180 2.8e-19 64.4 In-house 71-220 (290) alignment
Range on Protein: 25-180
Range on HMM: 71-220/290.0
KDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEK----KCAEYYSDKVGGVLKFGRYSLKTidvktdlKEFTDKKGFTLYTVEITNSKKKdapKKTV
| .. ..|| ||.| .. | .|   |.|| | | ...     ||.|. ..||. |||.  ..|        |.   ....   .....  ...   . ||
kitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.......kskekeddvetRelvvkfddee...eftv

DILYFSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLIM
.   ..|| .  ....   .|..... . .|  |.|||  |. |  .| ||. |  ... 
tHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiae

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 27-174 4.4e-19 63.2 In-house 87-223 (281) alignment
Range on Protein: 27-174
Range on HMM: 87-223/281.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVktdlkefTDKKgfTLYTVEITNSKKKDApkKTVDILYFS
  ||| |    | .| | | .  | || |.| . .|||||.  .   .|.| ..|..  |        | .|  .| |  .  | . ..  . .    . 
qgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyeds.......tvnk..slvttrlnlsyeget..rlithwlwk

GWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYG
 |||   |. .   |..|.   .     ..||||||||.|||.|..  
ewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveia

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 28-176 5.7e-19 63.3 In-house 59-200 (250) alignment
Range on Protein: 28-176
Range on HMM: 59-200/250.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKkCAEYYSdkVGGVLKFGRYSLKtidVKTdLKEFTDkkgFTLYTVEItnSKKKDAPKKTVDILYFSG
.| ..| |. | .. .....  | | ...| |.. . .|.   | .  |.|   ..   ..   .||.|   .|  .. .  ||.| | ...|  | |  
gPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..vekaekyGdvtvs...lls.keefad...ytkrklkl..skakkaderivrqlhfvv

WPDHGAPQEAYPALEMLKFCESYKKN-----VLVHCSAGVGRTGTLVAIKYGIE
||| | |..|  .||.||  .. ...     |.|.|||||||.|. .||.  .|
WPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavle

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 27-173 1e-18 62.5 In-house 98-239 (297) alignment
Range on Protein: 27-173
Range on HMM: 98-239/297.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkKCAEYYSDKvgGVLKFGRYSLKTIDVktdlkefTDKKGFTLYTVEITNSKKKDapKKTVDILYFS
  |.|.| .  ||.. ...|.. | |    |... ||| |.|||  || .||  |...  |       ....||   ..|.|..| |   .. |.   | 
qmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdk..gvttfGdvsvvllsv.......sereGfikrelevtkgkaka..rrvvkqyqfv

GWPDHGAPQ-EAYPA-LEMLK-FCESYKK----NVLVHCSAGVGRTGTLVAIKY
 |||.  .. .  .. |....   .....     .||||.||||||| |..|. 
eWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltids

0051082 (Phosphotyrosine protein) phosphatases II 35-201 1.8e-18 62.1 In-house 23-147 (151) alignment
Range on Protein: 35-201
Range on HMM: 23-147/151.0
EKHWAVIDQHNVAICVQLCSFVEGEekKCAEYYSDKVggvlkfgryslktidvktdlkeftdkkgftlytveitnskkkdapkKTVDILYFSGWPDHGAP
. ... . ....   | |.| .| .  .|.||. .                                                 .|  ... .|||.| |
adflellkelgiktivnlrseeerg..ycpeylpelg..............................................ievlhipildwpdpglp

QEAYPALEMLKFCESY-KKNVLVHCSAGVGRTGTLVAI-----KYGIELLIMPVRQCRYGAVQDESQITYLLL
.    .||.|.....  ...||||||||.||||||||.     .. .|  .  .|..| |.|| . |. ..|.
lsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllgvsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_Ptp69D_pd Subfamily Ptp69D 28-173 3.6e-18 60.7 In-house 98-241 (307) alignment
Range on Protein: 28-173
Range on HMM: 98-241/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGryslktiDVKTDLKEFTDKKGFTLYTVEITNSKKKD---APKKTVDILY
.|  .| .  | .| . .| . | |    | ..|||| |...      ..|       |.  .| ..  .. ..  ...... |..      .. |    
dPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg.......dilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyh

FSGWPDHGAPQEAYPALEMLKFC-ESYKKN---VLVHCSAGVGRTGTLVAIKY
. ||.|  .|. |   |....   | ||.|   ..|||||||||.|..||.. 
ytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 22-186 4.1e-18 60.4 In-house 29-183 (255) alignment
Range on Protein: 22-186
Range on HMM: 29-183/255.0
EDKKDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDvktdlkeftDKKGFTLYTVEITNSKKKDAPKKTVD
 |||  |    | .| . .| | .    | || | | . .|| .|.  .  . ||.   .. | .               | |.|||    .    .|| 
kdkkrknlysltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.........ssadvvlrtleitstlgekkkthtvk

ILYFSGWPDHGAPQEAYPALEMLKFCESYkKNVLVHCSAGVGRTGTLVAIKYGIELLIMPVRQCR
   . ||... ||..|   |..||      | |.||||.|.||. ..| . .    .|. ...  
hysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldtte

subfamily_PTPN23_pd Subfamily PTPN23 28-174 1.4e-17 58.4 In-house 90-234 (288) alignment
Range on Protein: 28-174
Range on HMM: 90-234/288.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRyslktidVKTDLKEFTDKKGFTLYTVEITNSKKKDapKKTVDILYFSG
 |..||    | .. .  . . | | |  | ...|...|.  . |   |||        ..  ||. .. . .  ......  ...   .|.|  | .  
aPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd.......lsvtlksvretethvervlkletldada..vksvshlqlts

WPDHGAPQEAYPALEMLKFCES--------YKKNVLVHCSAGVGRTGTLvAIKYG
||..|.|.     |..|.  ||         |. ..|||||||||||.. |. |.
WpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf.alvya

subfamily_PTPRK_pd Subfamily PTPRK 28-177 9.6e-17 55.8 In-house 93-236 (314) alignment
Range on Protein: 28-177
Range on HMM: 93-236/314.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGvlkFGRYSLKTIDVKTDlKEftdkkgFTLYTVEITNSKKKDAPKKTVDILYFSG
.|...| .  | .. ..| |  | |  .||    || .|. ..      .|   .. ...... .|      .   .  .......   ...|  . | |
gPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetell.ae......lvvrifrveklargqeeirevrqfqflg

WPDHGAPQEAYPALEMLKFCESYKK----NVLVHCSAGVGRTGTLVAIKYGIEL
||||. |..|   |....  .. ..    ...|||||| ||||| .||.  ...
WpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldm

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 6-172 1.2e-16 55.6 In-house 29-193 (237) alignment
Range on Protein: 6-172
Range on HMM: 29-193/237.0
VDFLNDQVFQGpMDGTEDKK--DGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVggvlKFGRYSLKTIDVKTDlKEFTDkkgFTLY
.|..|   ..| .|||  |      | .|.|.  | .. | . .. | |  ..||.|.|| .|. .      .   |   |. .| . .||.|   .|. 
sdyinatylkg.fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd....qpaaygvltvslkkk.eefsd...ytvr

TVEITNSKKKDaPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYK------KNVLVHCSAGVGRTGTLVAIK
.. ...  ..    . .    |. |||.| ||..   | . |               ..|||||||||| .. | 
slllskrltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvid

0049772 (Phosphotyrosine protein) phosphatases II 29-205 1.2e-16 56.7 In-house 92-272 (314) alignment
Range on Protein: 29-205
Range on HMM: 92-272/314.0
PKKSTCEKH----------WAVI--DQHNVAICVQ---------------------LCSFVEGEekkcaeyysdkvggvlkfgryslkT------IDVKT
|.. |..            | ..  ...|| . |                      |... ..                                ..   
pleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........................neptaadlellk

dlkeftdkkgftlytvE-------ItnskkkdaPKKTVDILYFsGWPDHGAPQEAYpALEMLKFCES--YKKNVLVHCSAGVGRTGTLVAIKYGIELL--
                |                ..  .  |..  .||..|| ...  .|.|.|.|.   ...|||||.||.|||||.|.. | . ||  
................eelydpelf........erlgikylri.pvpDgsaplled.fdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgv

-----IMPVRQCRYgAVQDESQITYLLLFVTK
     .  ||..|. .   ...|  |.... .
sleealedvrlkRp.inpnpgfieqleqyefi

PTPc_DSPc_SM00012 119-178 1.3e-16 56.0 In-house 1-66 (105) alignment
Range on Protein: 119-178
Range on HMM: 1-66/105.0
TVDILYFSGWPDHGAPQEAYPALEMLKFCESYKK------NVLVHCSAGVGRTGTLVAIKYGIELL
||  ....||||||.|.|. . ||.|. ... |.      .|.||||||||||||.||. . .. |
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqql

subfamily_PTPN1_pd Subfamily PTPN1 27-172 1.6e-16 54.9 In-house 77-222 (290) alignment
Range on Protein: 27-172
Range on HMM: 77-222/290.0
GNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVG-GVLKFGRYSLKTIDVKTDlkeftDKKGFTLYTVEITNSKKKDApkKTVDILYF
  |  .|..  | .. ...    | |  .|| |. |||.|.  .     |..   .||   ....     .|. .|. ..|..| | ...  ...   ..
qGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvklisee.....rksyytvrllelenlktqet..reilhfhy

SGWPDHGAPQEAYPALEMLKFCE---SYKK---NVLVHCSAGVGRTGTLVAIK
  ||| | |.     |..|  .    | ..    ...|||||.||.||.. . 
ttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvd

subfamily_PTPN14_pd Subfamily PTPN14 28-171 3.7e-16 54.0 In-house 100-249 (300) alignment
Range on Protein: 28-171
Range on HMM: 100-249/300.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDK--VGGVLKFGRYSLKTidvktDLKEFTDKKGFTLYTVEITNSKKkdapKKTVDILYF
 | . |....| .. ...|.. |.| .  |.  .|. .|. ..      ..||.. . |      ..| .|.   | ....   ||.    ..|| .| .
gPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt.....kfsedsdsvittglklkhlpske....ertvwhlqy

SGWPDHGAPQEAYPALEMLKFCESYKK-------------NVLVHCSAGVGRTGTLVAI
  ||||| |..  . |. |.  .| ..              ||||||||||||| |.  
tDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlils

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 28-172 4e-16 53.8 In-house 99-233 (315) alignment
Range on Protein: 28-172
Range on HMM: 99-233/315.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvggVLKFGRYSLKTIDvktdlKEFTDKkgFTLYTVeitNSKKKDAPkKTVDILYFSG
 |. .. .  | .. .....  | | . ||||..|. .|. ||    . .|....  ..     .|  ..  .|  |.       .|   ..|  | .. 
gpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrks.....eevnte..ytvrtl...svvfgdni.revvqlhyts

WPDHGAPQEAYPALEMLKFCESYKKN----VLVHCSAGVGRTGTLVAIK
||| | |. . | ... .    ...|    ..||||||||||||.....
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitld

subfamily_hpo-7_pd Subfamily hpo-7 32-179 4.7e-16 53.5 In-house 45-182 (263) alignment
Range on Protein: 32-179
Range on HMM: 45-182/263.0
STCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTdlkeftdkkGFTLYTVEITNSKKKDAPKKTVDILYFSGWPDH
 | .| .  | | .    | || | | . .|| .|.  .  . .|.   .. | .|.             | | |...  ..    .||    . ||...
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.........dvllktlellstlgeKkkthtvkhysykgWiek

GAPQEAYPALEMLKFCESYkKNVLVHCSAGVGRTGTLVAIKYGIELLI
 .|..|   |..||      |.. ||||.|.||.   . .      .|
ndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmi

subfamily_PTPRN_pd Subfamily PTPRN 29-184 2.9e-14 47.5 In-house 108-257 (297) alignment
Range on Protein: 29-184
Range on HMM: 108-257/297.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYSLKTIDVKTDLKEFTDKkGFtlYtveITNSKKKDapKKTVDILYFSGW
|  ||  . | .. .. |.. |.|..  | . |.|..|. |.  |   .. | .. .  .   ...  .  |  |   . | ....   .||  ..|  |
plastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvr.sf..y...lknlqtse..trtvtqfhflsw

PDHGAPQEAYPALEML-KFCESYKK---NVLVHCSAGVGRTGTLVAIKYGIELLIMPVRQ
|..|.| .| . ||.  |   ||.     ..||||.|.||||. ..|   .. |.  |..
peegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvke

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 25-179 8.1e-14 45.9 In-house 95-240 (439) alignment
Range on Protein: 25-179
Range on HMM: 95-240/439.0
KDGNPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkkcaeYYSDKvgGVLKFGRYSLKtIDVKTDLKEFTdKKGFTLYtveitNSKKKDAPKKTVDILY
.   ||| |... | .. .....  |.|. .||        |.  .  .   .|  ... .| . .| ...  .|| ..     | . .   ..||  ..
atqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavr.vdrnielpnyv.irgfkvf.....nerdttekertvlqfh

FSGWPDHGAPQEAYPALEMLKFCESYKK-----NVLVHCSAGVGRTGTLVAIKYGIELLI
.  |||.  | .|   |..|.  .| .       |.||||||||||||..|.   .| | 
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk

subfamily_PTPN9_pd Subfamily PTPN9 29-149 1.1e-13 45.9 In-house 93-204 (297) alignment
Range on Protein: 29-149
Range on HMM: 93-204/297.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTdlkeftdKKGFTLYTVEITNSKKKDapKKTVDILYFSGW
| | |.. .| .. ...| . |    .||    ||..|. .. . . .|| .|.....|..       .. ..  ..||.|.|...  ...|    | .|
plkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.......eedykvrvleiknvktee..srkvthfqflsW

PDHGAPQEAYPALEMLKFCES
||.| |..|   |..|.   .
PdyGvPssaaslldvlekvre

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 29-182 1.6e-13 45.5 In-house 99-252 (325) alignment
Range on Protein: 29-182
Range on HMM: 99-252/325.0
PKKSTCEKHWAVIDQHNVAICVqLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVktdlKEFTDkkgFTLYTVEITNSKKKDapKKTVDILYFSGW
|. .| .  | .. . . .. | .   .......|| |. ...|   .||   .| . .    .|..|   .    ... . || .   ..|  . . .|
PltatindlWrlvldWrcsvvv.vlneldlgkdrcavywpkemgksktfGglevklrti....eeisd...yvhrvldvkqvkkGe..trsvkqfqlqsw

PDHGAPQEAYPALEMLKFCES----YKK------NVLVHCSAGVGRTGTLVAIKYGIELLIMPV
.| | ..     . .|.  .      .        .||||||||||||.....   .. .|   
ddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviees

subfamily_CG7180_pd Subfamily CG7180 29-178 3.6e-13 43.8 In-house 93-250 (296) alignment
Range on Protein: 29-178
Range on HMM: 93-250/296.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEkKCAEYYSDKVggVLKFGRYSLKTIDVKTdLKEFTDKKgFTLYTV---EITNSKKKDAPKKTVDILYF
|||.| ...| .. ....   | |.   . .. .. .|.  |     ..|   .... .|. . ... .. | |.        . |. .|....|  . .
pkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekq.yanlkirt.fkltkkivalteqekqvkaetRivklfql

SGWPD-HGAPQEAYPALEMLKFCESYKKNV---------LVHCSAGVGRTGTLVAIKYGIELL
  |.  .  |  .   .|...  ......|         .|..| |..|.|  .||   .||.
teWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 28-226 2e-12 41.5 In-house 87-278 (287) alignment
Range on Protein: 28-226
Range on HMM: 87-278/287.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvGGVLKFGRYSLKTIDVKTDLKEftdkkgFTLYTVEITNSKKKDApkKTVDILYFSG
 |  .|  . | .. ....|  . .   ||   .|| .|. ..    .. | ||.  .| .    |      ..  .. . . . ..|  . |  | .  
gPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePe......ygvralrlidletrea..rvvkqldlls

WPDHGAPQE----AYPALEMLKFCESYKK-----NVLVHCSAGVGRTGTLVAIkygielLIMPVRQCRYGAVQDESQITYLLLFvTKGLMeKVPVTYLHS
|||....      .  .|.. .. |  ..      ..||...|.||.|.|.|.      |..  |    | |     . .|. .  ..|. . .| .  .
wPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillat......lvlvsrledlGrvdvaavvirlrey.raalv.qavvqlrll

FNVLQ-YYH
.. |  ||.
yealvtyyk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 34-172 2e-12 41.8 In-house 65-195 (239) alignment
Range on Protein: 34-172
Range on HMM: 65-195/239.0
CEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFgRYSLKTIDVktdlkeFTDkkgFTLYTVEItnSKKKDAPKKTVDILYFSGWPDHGA
.   | .. |   .. | |  ..|| .||| .|. |      .. | .|.  .|      |.|   . . |. .  |.  .. .. |   .|. |||.| 
sgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.rvtlrktev......fad...yiirtfvm..sqvgqteeryvyqyhftvwpdkgv

PQEAYPALEMLK----FCESYKKNVLVHCSAGVGRTGTLVAIK
|| |   | . .          .  ..||||||||||... | 
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 34-172 2e-12 41.8 In-house 64-194 (239) alignment
Range on Protein: 34-172
Range on HMM: 64-194/239.0
CEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFgRYSLKTIDVktdlkeFTDkkgFTLYTVEItnSKKKDAPKKTVDILYFSGWPDHGA
.   | .. |   .. | |  ..|| .||| .|. |      .. | .|.  .|      |.|   . . |. .  |.  .. .. |   .|. |||.| 
sgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnl.rvtlrktev......fad...yiirtfvm..sqvgqteeryvyqyhftvwpdkgv

PQEAYPALEMLK----FCESYKKNVLVHCSAGVGRTGTLVAIK
|| |   | . .          .  ..||||||||||... | 
pqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 28-197 4.9e-12 40.1 In-house 92-265 (301) alignment
Range on Protein: 28-197
Range on HMM: 92-265/301.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTdLKEFTD-------KKGFT-LYTVEITnSKKKDAPKKT
.| |.|    | .| |. ..  | ..   || ..|| .|...      .||  . . .. .. . .|.        ..|.   |.      .|.|   ..
gpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkf.kvksdksswd

VDILYFSGWPDHGAPQEAYPALEMLK-----FCESYKKNVLVHCSAGVGRTGTLVAIKYGIEllimpvrQCRYGAVQDESQIT
|  |    ||..|  .|    |. .           .  |.||||..|.|.|. ...  |.|       ||.   | |  |.|
vlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglE.......QckaegVVdvfqvt

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 28-172 1.2e-11 38.6 In-house 95-190 (392) alignment
Range on Protein: 28-172
Range on HMM: 95-190/392.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEekkcaeyysdkvggvlkfgryslktidvktdlkeftdkkgftlytveitnskkKDAPKKTVDILYFSG
 |. .. .  | .. |.||.  . .  . ||.                                                     |   ..||   .|. 
gpnaaslddfwrmvfqenvttiamvtklkegd.....................................................kgddartvaqfhfte

WPDHGAPQEAYPALEMLKFCE----SYKKNVLVHCSAGVGRTGTLVAIK
|||.. |. .   |...|  .    .| . ...|||||||||| ...| 
wPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

0038934 (Phosphotyrosine protein) phosphatases II 128-203 1.8e-11 39.5 In-house 87-173 (194) alignment
Range on Protein: 128-203
Range on HMM: 87-173/194.0
WPDHGAPQEAYPALEMLKFC-----ESYKKNVLVHCSAGVGRTGTLVA------IKYGIELLIMPVRQCRYGAVQDESQITYLLLFV
.||.|..      |. |...     |. .. |.||| ||.||||||||       ..  |  |  .|..| ||..  ... .|| ..
fpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 28-175 2.8e-11 37.8 In-house 82-223 (283) alignment
Range on Protein: 28-175
Range on HMM: 82-223/283.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKvgGVLKFGRYslkTIDVKtdlKEfTDKKGFTLYTVEITNSkkkDAPKKT--VDILYF
 | . |    | .. .....  | |  . |....||. |.  .  |  ..| .   |. ..   || | .. |.   . . ..    . |.|  .    .
sPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr..GsedyGef...tvtlr...ke.ttsnsfiikelllrvn...ssakstlllahyqv

SGWPDHGaPQEAYPAL---EMLK--FCESYKKNVLVHCSAGVGRTGTLVAIKYGI
 .| . | .|    .|   . ..    || |  ..||||.|.|||....|.   .
idWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 29-135 9.9e-10 32.7 In-house 84-181 (297) alignment
Range on Protein: 29-135
Range on HMM: 84-181/297.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVLKFGRYSLKTIDVKTDlkEFTdkkgfTLYTVEITNSKKkdAPKKTVDILYFSGW
| ..| . .| .. ...| . | .. . |.  .||| |. . |.. || | . .. .   .|  ||      ...  |..   .  . .. |    | .|
plsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsd..efd.....rviltelqliyr..sesrvvrhvqflsw

PDHGAPQ
|||| | 
pdhGvps

DSPc Dual specificity phosphatase, catalytic domain 92-184 2.4e-09 32.1 Pfam-A 11-105 (133) alignment
Range on Protein: 92-184
Range on HMM: 11-105/133.0
KEFTDKKGFTLyTVEITNSKKKDAPKKTVDILYFSG----WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVaIKYGIELLIMPVRQ
.....|.|.|| ....|......  .|. .| |..       .    .|   | |... .|. .|.||||| ||. |..||. | | ..   .....
lalleklgitl.vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktknlslne

DSPc Dual specificity phosphatase, catalytic domain 92-184 2.4e-09 32.1 In-house 11-105 (133) alignment
Range on Protein: 92-184
Range on HMM: 11-105/133.0
KEFTDKKGFTLyTVEITNSKKKDAPKKTVDILYFSG----WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVaIKYGIELLIMPVRQ
.....|.|.|| ....|......  .|. .| |..       .    .|   | |... .|. .|.||||| ||. |..||. | | ..   .....
lalleklgitl.vinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatli.iaYlmktknlslne

0048567 (Phosphotyrosine protein) phosphatases II 119-200 2.4e-09 31.7 In-house 36-132 (157) alignment
Range on Protein: 119-200
Range on HMM: 36-132/157.0
TVDILYFSGWPDHGaPQE-------AYPALEMLKFCESYKKNVLVHCSAGV---GRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQITYLL
. ...|.. . |.| | .       .. . ..||..|  .| . |||.||    |||.||..       ..  |  | |.|..| | |    .  .|.
ddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasylls

PTPc_motif_SM00404 134-183 6e-09 30.9 In-house 63-111 (140) alignment
Range on Protein: 134-183
Range on HMM: 63-111/140.0
PQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVaIKYGIELLIMPVR
 ..   .|.... .|. ...||||| ||| |..||. | | ..   . ..
skyldkvldfienaekkggkvlVHCqaGvSRSatli.iaYlmryrqlsla

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 29-176 7.1e-09 29.6 In-house 102-248 (310) alignment
Range on Protein: 29-176
Range on HMM: 102-248/310.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSdKVGGVLKFGRYSLKTIDVKTDLKEFTDKK-GFTLYTVEITnSKKKDAPKKTVDILYFSG
| . |    | .| |      . ||  .|    ||  |.   .|    .|   .  .   ..  |  .    |    | .   .  .  .  |... .  
plqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvd.eqpanlkelrvslikwpn

WPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIE
||| | |.|   ..    ...  .  ..||||||..|....||.|. |.
wpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkid

subfamily_ptpA1_pd Subfamily ptpA1 29-170 8.2e-09 29.7 In-house 97-248 (418) alignment
Range on Protein: 29-170
Range on HMM: 97-248/418.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVlKFGRYSLKTIDV---KTDLKEFTDKKGFTLYTVEITNSKKKDApkKTVDILYF
|   |    | .. .  . | | |    |    ||  |. ...||  .|  |      .     .| |  .     . | .|  . . ..  . .    .
plpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.qfsiygngnevfgtysvelveviqdpereiitrnirltfeget..rditqyqy

SGWPDHGAPQEAYPALEMLKF--------CESYKKNV--LVHCSAGVGRTGTLVA
 |||||  |. . |  ..|.           |  .||  .||||||||||||...
egwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct

subfamily_egg_pd Subfamily egg 28-231 8.4e-09 29.5 In-house 90-275 (307) alignment
Range on Protein: 28-231
Range on HMM: 90-275/307.0
NPKKSTCEKHWAVIDQHNVAICVQLCSFVEGeeKKCAEYYSDKVGGVLKF--GRYSLKTIDVKTdlKefTDkKGFTLYTVEITNSKkkdapkktVDILYF
 | | | .  | .. | .|   | | | .|   ..|  |.       |..  | . .....|.   |  .|   |..  . .  ..         . .. 
aplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvds..k..ad.plfrvtklklvGgd........deerfl

SGWP-DHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAIKYGIELLIMPvRQCRYgAVQDESQitylLLFVTKGLMEKVPVTYLHSFNVLQY
  |  |     . |  |..|.      | |.|..  || ...|||||.  .  |.      ..  |.   .    .|   . |  . .. ||  . .. .
ehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrG.pitks.lvlravv....flrlrrrlsvesvllylfvyrlvlf

YHNQVIS
.  .||.
ffrdvig

subfamily_PTPDC1_pd Subfamily PTPDC1 123-202 8.9e-09 30.0 In-house 85-171 (182) alignment
Range on Protein: 123-202
Range on HMM: 85-171/182.0
LYFSGWPDHGAPQEaYPALEMLKFCESY--KKNVLVHCSAGVGRTGTLVAI------KYGIELLIMPVRQCRYGAVQDESQITYLLLF
 |  ||.|.|..     .|.. |  ..   ...| ||| || |||| |.|       ..  |  |  ||. |  ..|  .|.  .  |
vynfgwkDygvasl.eriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkef

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 122-174 1e-08 29.3 In-house 219-285 (350) alignment
Range on Protein: 122-174
Range on HMM: 219-285/350.0
ILYFSGWPDH---GAPQEAYPALE------MLKFCESYK-----KNVLVHCSAGVGRTGTLVAIKYG
 |..  |.|      |..  .|||         |.||.      . .|||||||||||||||.. . 
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsl

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 117-172 1.3e-08 28.6 In-house 88-148 (440) alignment
Range on Protein: 117-172
Range on HMM: 88-148/440.0
KKTVDILYFSGWPDHGAPQEAYPALEMLKFC-ESYKK----NVLVHCSAGVGRTGTLVAIK
 .|.   .. ||||.| |. | | |.|..   || .|     .|||||||.|||| ..|. 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavd

PTEN_1 127-170 1.5e-08 29.7 In-house 101-149 (196) alignment
Range on Protein: 127-170
Range on HMM: 101-149/196.0
GWPDHGAPqEAYPALEMLKFCESY------KKNVLVHCSAGVGRTGTLVA
...|||||      ....| ....      ...||||| ||.||.||.||
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 152-184 3.5e-08 27.2 In-house 266-298 (349) alignment
Range on Protein: 152-184
Range on HMM: 266-298/349.0
KNVLVHCSAGVGRTGTLVAIKYGIELLIMPVRQ
  .||||||| ||||.|| . . ...|... ..
stllvhcsaGcGrtGvlvtldlllsileplqne

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 29-175 1.1e-07 26.1 In-house 80-216 (267) alignment
Range on Protein: 29-175
Range on HMM: 80-216/267.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEekkCAEYYSDKVGGVLKFgrySLKTIDvkTDLKEftDKKGFTLYTVEItnsKKKDAPKKTVDILYFSGW
| | |  ... || ...|.. | |    ...      ..  |.|   |.      |..    |..  ... . . |.|.   | |.   . | . |.  |
plkntitdfltvihdqkvpvivlltkvftdn...irlfwPPkmgqakky...qdltve..hslek..eendyqiitlel...kfknesahnvtlyyykkw

PDHGAPQEA-YPALEML--KFCESYKKNVLVHCSAGVGRTGTLVAIKYGI
      .    | . .|  .  |   . ..|.||.||||.||.. |.  .
nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsql

subfamily_CDC14_pd Subfamily CDC14 142-193 1.4e-07 25.7 In-house 254-311 (328) alignment
Range on Protein: 142-193
Range on HMM: 254-311/328.0
EMLKFCESYKKNVLVHCSAGVGRTGTLVAI----KYGIE--LLIMPVRQCRYGAVQDE
..|. .|. . .. ||| ||.||||||.|     .|..     |  .| || | |   
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigp

subfamily_CG42327_pd Subfamily CG42327 29-145 4.4e-07 23.9 In-house 80-188 (319) alignment
Range on Protein: 29-145
Range on HMM: 80-188/319.0
PKKSTCEKHWAVIDQHNVAICVQLCSFVEGEEKKCAEYYSDKVGGVlKFGRYSlktiDVKTDLKEFTDKKGFTLYTVEITNSKKKDAPKKTvdILYFsGW
. ...  . | .. . .  . |||..  |   |.||||.  | ..      |     |..  ||.   |. . . |. . . .|. . . |    ..  |
sledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld.ntslyG....dilvtlkgrevkdryaistlllkrvdkeesrelt..hywy.kw

PDHGAPQEAYPALEMLK
.. . | |  . . || 
leaevPaeeaaliamll

subfamily_PRL_pd Subfamily PRL 141-199 9.4e-07 23.0 In-house 80-142 (151) alignment
Range on Protein: 141-199
Range on HMM: 80-142/151.0
LEMLKFCESYKKNVLVHCSAGVGRTGTLVAIK---YGIEL--LIMPVRQCRYGAVQdESQITYL
| . ||.|. |. | ||| ||.||.  |||.     |..    .  .|. | ||.  . |...|
llkekfkeepkstvavhcvaGlGraPvlvalalieaGmkyedavefirekrrgain.skqlkfl

subfamily_DSP15_pd Subfamily DSP15 106-171 2.9e-06 21.4 In-house 33-98 (151) alignment
Range on Protein: 106-171
Range on HMM: 33-98/151.0
EITNSKKKDAPKKTVDILYFSGWPDHGAPQEAYPALEMLKFCESYKKNVLVHCSAGVGRTGTLVAI
 . ...||  ....  ..  |  |.    .    . |..  | . ..|||||| ||| |  |||..
svhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva

subfamily_PTPN9_pd Subfamily PTPN9 154-178 5e-06 20.8 In-house 226-250 (297) alignment
Range on Protein: 154-178
Range on HMM: 226-250/297.0
VLVHCSAGVGRTGTLVAIKYGIELL
..||||||.|||||.... . .. |
ivvhcsaGiGrtGtfitldiclsrl