Gene T22C1.8 in Caenorhabditis elegans

Synonym: CELE_T22C1.8, T22C1.8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf9
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP186_AA protein Get Run
CeleP186_AA_111-384 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 106-385 2.2e-170 559.8 In-house 8-290 (290) alignment
Range on Protein: 106-385
Range on HMM: 8-290/290.0
DVQKKVFFKFASDAVKKNPPEYSVEFMTKVKPY-PGQPMERKIFDANP--TKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGLNAPFILTQGATAATV
 || ..|.|||||.||||..|...|...|.||| |.|..||||||.|.  .|||||||||||.|||||.||.||||.|||||.||.|.|||||||...||
svqteafekfasdvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGydGdyvhanyvkGlkamfiltqGalkdtv

IDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLR
||.||||...|.|.||||||..|||||||.||||||.||..|||..|.|||.||||||||||.|||||..|.||||.||||..|||||..|..||.||||
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallr

MLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWD
.|.|.|.|||||.|||||||||||||||||..||||.||||||||...|||||||..|.||||||.|||.||...|||..|..
tlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdfkyie

0050432 (Phosphotyrosine protein) phosphatases II 122-380 3.6e-81 268.2 In-house 39-301 (308) alignment
Range on Protein: 122-380
Range on HMM: 39-301/308.0
KNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILsdGGDGDYIHANYVNGL----NAPFILTQGATAATVIDFWRMVVHTKTAYI
...  .. ||..  . .|  ...   . .| .||||||....| .||.|  ... |||.|.||.|     .  ||.||| .  || |||||| . .. .|
ldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvI

VMLCEVMEDGKAKCAQYYPEKAG-EAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA--SGPV
|||.. .|.|. |||||.|.. | . ...| .|. .  |.  ......||| ..|...|......|.| ..||| .||.|. .||..| .||.   .||.
vmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpi

TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
 ||||||.||||||.|.. .|. |  ....|.... . ||  |.|..|   ||. | ..|. | |.
vVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0036941 (Phosphotyrosine protein) phosphatases II 129-383 8.6e-79 260.2 In-house 17-282 (297) alignment
Range on Protein: 129-383
Range on HMM: 17-282/297.0
VEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILsDGGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMED
 ||.. .. ..  ...  .. .| .||||||....| |||.| |... |||.|.||.| .    ||.||| .  || |||||| . ..  ||||.|..|.
kefeellpllllgslsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvel

GKAKCAQYYPEKAGEAMTFGAWTILCSLEDDK-DANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPVTVHCS
|. |||||.|.. || .|.| .|. .  .. . ..... ||| | ...||......|.| ..||| .||.|.  ||...  ||.       .||| ||||
grekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCs

AGIGRTGTFVAIEACLQILT---DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGY
||.||.|||.|.. .|| |      ...|.| . . ||. |.|..|   ||. | ..|... | . .
aGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt

0040438 (Phosphotyrosine protein) phosphatases II 113-385 1.6e-77 256.2 In-house 6-283 (317) alignment
Range on Protein: 113-385
Range on HMM: 6-283/317.0
FKFASDAVKKNPPEYSVEFMTKVKPYPGqPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNGL--NAPFILTQGATAATVIDFWR
 ..  | .|..    . ||..  .  .  ...  .. .|. ||||.|....| .||.||. |     |||.|.||.|   .  ||.||| .  || ||||
llalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV
|| . .. .||||.| .|.|. |||||.|.  || .|.| .|. .  |.  .|.|. ||| | . .........|.| ..||| .|| |.  ||..| .|
mvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

RTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWD
|.|    .||| ||||||.||||||.|.. .|. |  ....|.  . . ||. |.|..|   ||. | ..|..| | .... 
realedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltle

0046845 (Phosphotyrosine protein) phosphatases II 132-380 1e-76 253.3 In-house 7-276 (284) alignment
Range on Protein: 132-380
Range on HMM: 7-276/284.0
MTKVKPYP--GQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD----GDYIHANYVNGL-------NAPFILTQGATAATVIDFWRMVVHTKTAYIV
.. .. ..    ...  .. .| .||||||....| .||.|.  ..    .|||.|.||.|        .  ||.||| .  || |||||| . .. .||
eellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIV

MLCEVMEDGKAKCAQYYPEKaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA------S
||.| .|.|. |||||.|.. || .|.| .|. .  |.  . ....|||...|.. .|......|.| .||||..|| |.  ||..| .||..      .
mltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgg

GPVTVHCSAGIGRTGTFVAIEACLQILTDGK---ELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
||. ||||||.||||||.|.. .|. |  ..   ..|.|.. . ||. | |..|   ||. . ..|..| | 
gpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl

0051299 (Phosphotyrosine protein) phosphatases II 112-377 4e-76 251.5 In-house 10-285 (288) alignment
Range on Protein: 112-377
Range on HMM: 10-285/288.0
FFKFASDAVKKNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNG--LNAPFILTQGATAATVIDFW
..|.    .....  .  || . .. .|  ..   .. .| .||||.|....| .||.||. ..   .|||.|.|..|  |.  ||.||| .  || |||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

RMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNV----DNGKEHILKHLHTKSWPDRCVPNSTMALLR
||| . .. .||||....|.|. |||||.|.  |. .|.| .|. .  |.  ......||| |.|.     .|.... .|.| ..||| .||.|. .||.
rmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellld

MLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
.| .||.|    .||| ||||||.||||||.|.. .|. |  ....|.|.. . ||. | |..|   ||. . ..|. |
flrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

DSPc_SM00195 137-377 1.4e-75 249.4 In-house 12-261 (263) alignment
Range on Protein: 137-377
Range on HMM: 12-261/263.0
PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKC
 .. .... .....| .|||||.....| |||.|..     . |||.|||..|   .  .|.||| .  || ||||||...|. .||||.| .|.|| ||
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

AQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGT
..|.||..|. .|||  .. .  .. |...||.|||.... .. ... ..... |.|||. ||.||. .|..|  |..     |||. ||||||.|||||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgt

FVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||.|. .|. |...|..|.  ....||..|.|..| . ||.........|
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 137-377 1.4e-75 249.4 In-house 12-261 (263) alignment
Range on Protein: 137-377
Range on HMM: 12-261/263.0
PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKC
 .. .... .....| .|||||.....| |||.|..     . |||.|||..|   .  .|.||| .  || ||||||...|. .||||.| .|.|| ||
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

AQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGT
..|.||..|. .|||  .. .  .. |...||.|||.... .. ... ..... |.|||. ||.||. .|..|  |..     |||. ||||||.|||||
drywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgt

FVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||.|. .|. |...|..|.  ....||..|.|..| . ||.........|
fvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

0047943 (Phosphotyrosine protein) phosphatases II 127-377 1.7e-75 249.3 In-house 14-271 (273) alignment
Range on Protein: 127-377
Range on HMM: 14-271/273.0
YSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILsDGGDGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVM
.  || . .. .|  ...  .. .| .||||||....| .||.| ..|. |||.|.||.|  |.  ||.||| .  || |||||| . .. .||||.|..
lleefelllslkplltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelv

EDGKAKCAQYYPEKAGE-AMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPVTVH
|.|. |||||.|.. ||  .|.| .|. .  |.  ......||| ..|...|.... .|.| ..||| .|| |.  ||... .||.       .||| ||
elgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVH

CSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||||.||||||.|.. .|. |  ....|.| . . ||. | |..|   ||. | ..|..|
CsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

Y_phosphatase Protein-tyrosine phosphatase 151-375 3.4e-73 241.3 Pfam-A 1-234 (235) alignment
Range on Protein: 151-375
Range on HMM: 1-234/235.0
NPTKNRYKDVVCNDITRVIL-SDGGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA
| .||||||... | ||| | ...|. |||.||||.|   .  ||.||| .  |. ||||||.. |. .||||....| |. |||||.||. .| .|.| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

WTILCS-LEDDKDANIIKRTLSVRNVDNGK-EHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS----GPVTVHCSAGIGRTGTFVAIEACLQILTDG
 .. .   | ....... |.|.... .. . ....|.|| ..|||..||.|. .||...  |.. .    |||.||||||.||||||||....|. |...
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

KELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
.|.|.| ... ||..|.|..|   ||..|.....
eevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 151-375 3.4e-73 241.3 In-house 1-234 (235) alignment
Range on Protein: 151-375
Range on HMM: 1-234/235.0
NPTKNRYKDVVCNDITRVIL-SDGGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA
| .||||||... | ||| | ...|. |||.||||.|   .  ||.||| .  |. ||||||.. |. .||||....| |. |||||.||. .| .|.| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

WTILCS-LEDDKDANIIKRTLSVRNVDNGK-EHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS----GPVTVHCSAGIGRTGTFVAIEACLQILTDG
 .. .   | ....... |.|.... .. . ....|.|| ..|||..||.|. .||...  |.. .    |||.||||||.||||||||....|. |...
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

KELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
.|.|.| ... ||..|.|..|   ||..|.....
eevdvlqivkelRkqRpgmvqsleqYiflykail

0045450 (Phosphotyrosine protein) phosphatases II 122-379 1.1e-71 237.4 In-house 26-305 (307) alignment
Range on Protein: 122-379
Range on HMM: 26-305/307.0
KNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDG----GDGDYIHANYV--------NG--LNAPFILTQGATAATVIDFWR
..  .   | . .|....  ...   . .| .||||||....| |||.||.     .|.|||.|.||        .|  |.  ||.||| .  || ||||
ltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwr

MVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNV-DNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYI
|. . .. .||||.| .|.|. |||||.|.. || .|.| .|. .  |.  ..... ||| | .   .|......|.| ..||| .|| |.  ||... .
mlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VRT------ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKE---LDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
||.       .||| ||||||.||||||.|.  .|. | ....   .||| . . ||. | |..|   ||. | ..|. . .
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

0039614 (Phosphotyrosine protein) phosphatases II 128-379 5.9e-70 231.4 In-house 35-290 (297) alignment
Range on Protein: 128-379
Range on HMM: 35-290/297.0
SVEFMTKVKPYPgqPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD----GDYIHANYVNGLNA---PFILTQGATAATVIDFWRMVVHTKTAYIVML
  ||.. ..  |  ...   . .| .||||||....| .||.|.. ..     |||.|.||.| .     ||.||| .  || |||||| . .. .||||
llefeellslkp..dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmL

CEVMEDGKaKCAQYYPEKAGeamTFGAWTILCSLEDDkDANIIKRTLSVRNvdNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPV
.. .|.|. |||||.||. |   |.| .|. .  ..  ..... |||.|.|  ||......|..  .||| .||.|.  ||..| .||.       .|||
tklvelgr.kcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpv

TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
 ||||||.||||||.|.  .|. |  ....|.| . . ||. | |..| . ||. | ..|. . |
lVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0043336 (Phosphotyrosine protein) phosphatases II 112-377 6.8e-70 231.0 In-house 7-276 (278) alignment
Range on Protein: 112-377
Range on HMM: 7-276/278.0
FFKFASDAVKKNPPEYSVEFMTKVKPYPgQPMERKIFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGL--NAPFILTQGATAATVIDFW
. |.  . .....  .. || .  .  .  ...  .. .| .||||||....| .||.||. |   | |||.|.||.|   .  ||.||| .  || |||
llkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFw

RMVVHTKTAYIVMLCEVMEDGKAKCAQYYPekaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYI
||| . ..  ||||.| .|.|. |||||.|   |. .|.| .|. .  |.  ..... ||| | |  .|....  |.| ..||| .|| |.  ||..| .
rmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

VRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
||.     .||| ||||||.||||||.|.. .|. | .....||. . . ||. |.|..| . ||. | ..|. |
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

0045098 (Phosphotyrosine protein) phosphatases II 128-379 6.4e-67 221.2 In-house 10-273 (278) alignment
Range on Protein: 128-379
Range on HMM: 10-273/278.0
SVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVIlsdggdgDYIHANYVNGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDG
. ||  .. ... . ..  ..  |  ||||||....| .||.       |||.|.|..| .  ||.||| .  || |||||. . .. .||||.|..|.|
llefefllllgipseitpalylgnldknRykdilpydhsrVk.......dYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KAKCAQYYPEkaGEAMTFGAWTILCSLEDDKdANIIKRTLSVRNV----DNGKEHILKHLHTKSWPDRCVPNST--MALLRMLYIVRT------------
. |||||.||  |. .|.| .|. .  |.    ....||| |.|.     ..... ..||| ..||| .||...  . .|..|  .|             
rekcaqywpe..ggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

-----ASGPVTVHCSAGIGRTGTFVAIEACLQILtdGKELDLLGTCRALRNSRAG-SIQVDIQYMALVQILINYGK
      .||| ||||||.|||||.||.  .|. |  .. .||| . . ||. | | ..|   ||. | . |. . .
lllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0040439 (Phosphotyrosine protein) phosphatases II 143-379 1.2e-64 213.7 In-house 3-247 (249) alignment
Range on Protein: 143-379
Range on HMM: 3-247/249.0
MERKIFDANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPE
..  .. .|. ||||.|....| .||.||.   . ..|||.|.|..|   .  ||.||| .  || |||||. . .  .||||.. .| |. |||||.|.
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

kaGEAMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT------ASGPVTVHCSAGIGRTGTFVAI
  |. ...| .|. .  ..   .... ||| . |. .|...  .|..  .|||  || |.  ||... .||.       .||| ||||||.||||||.|.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

EACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
  .|. |   ...||. . . ||. | |..| . ||. | ..|. . .
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll

subfamily_PTPRD_pd Subfamily PTPRD 130-377 1.9e-64 213.3 In-house 28-280 (564) alignment
Range on Protein: 130-377
Range on HMM: 28-280/564.0
EFMtKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVM
|.  |... .  ..|    .||  ||||...|  | .||.||      . ||| |....| ...  .| ||| .| |. ||||||   ... |||| .. 
eyk.kieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkle

EDGKAKCAQYYPEKaGeAMTFGAWTILCSlEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----ASGPVTVHCSA
| || ||..|.||| |   |.|  |.  . |  . |... ||..... .. . .  .. |  ||||..||.|. .||...  ||.     .||..|||||
EkgkvkchkYWPek.g.tetygeltVtle.eeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa

GIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
|.||||||..|.|.|. ... | .|. .. .|||. |   .|   ||. . ... ..
GVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea

0042113 (Phosphotyrosine protein) phosphatases II 147-377 2.6e-63 209.0 In-house 5-242 (245) alignment
Range on Protein: 147-377
Range on HMM: 5-242/245.0
IFDANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGE
.. .|..||||.|....| |||.||. |   | |||.|.||.|   .  ||.||| .. || |||||. . .  .||||.| .|.|. |||||.|.  ||
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..ge

AMTFGAWTILCSLEDDkDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLQ
 .|.| .|. .  |.  ..... |||.| |. .....   |.|  .||| .||...  ||..| .||.     ..||| ||||||.||||||.|.  .|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
 |   ....|  . . ||. | |..| . ||. | ..|...
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0037934 (Phosphotyrosine protein) phosphatases II 146-376 9.5e-60 197.5 In-house 5-240 (243) alignment
Range on Protein: 146-376
Range on HMM: 5-240/243.0
KIFDANPTKNRYKDVVCNDITRVILsDGgdGDYIHANYVNGLNApFILTQGATAATVID----FWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPekaGE
 .. .| .||||.|....| .||.| .|  .|||.||......  .|.||| .  || |    ||||. . .. .||||.| .| |. |||||.|   ||
allpenlsknrysdilpydhsrvkl.eg..sdyinanliyvtpr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp...ge

AmTFGAWTILCSLEDDKdANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVR------------TASGPVTVHCSAGIGRTGTF
  |.| .|. .  |  . .... |||...|.| .. ..   |.|  .||| .||.|.  ||..| .||              .||| ||||||.|||||.
v.tygdftvtllseehl.ddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

VAIEACLQILtdgkELDLLGTCRALRNSRAG-SIQVDIQYMALVQILIN
.|.  .|. |    ..||. . . ||. | | ..|   ||. | ..|. 
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPRB_pd Subfamily PTPRB 110-377 2.7e-59 195.6 In-house 10-284 (293) alignment
Range on Protein: 110-377
Range on HMM: 10-284/293.0
KVFFKFASDAVKKNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNAP--FILTQGATAATVID
. | .. ..  ...  ..| |. .  .    | ..     .| .||||....  | .|| |   .|  . ||| |||..|.|.|  || |||    || |
ekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvdd

FWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgEAMTFGAWTILCSLEDDKDaNIIKRTLSVRNvdNGKEHILKHLHTKSWPDRCVPNSTMALLRML
|||||  .|.  |||| ...| || || .|.|..  |....|  ..    |.... . . |.|....  . .|. ....| .||||  ||..| .||...
fWrmvwekkssiivmltqlvekgkvkCeeYWPade.epvlyGdikvtlvaeeele.dwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfv

YIVRTAS------GPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
. ||.|       .|..||||||.||||||.|..  || ...   .|..|.  .||..|.  .|   ||. . | ....
rtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

subfamily_PTPN3_pd Subfamily PTPN3 139-374 2.7e-58 192.1 In-house 29-271 (280) alignment
Range on Protein: 139-374
Range on HMM: 29-271/280.0
PGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVN------GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCA
||  ..     .| .||||.|..  |.|||.|...   ||| |||||      ||   .| |||  | |. |||.|| . |.  |||| ...|.|. || 
pglaisaarkpenlsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

QYYPEkAGEAMTFGAWTILCSLEdDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTF
||.||  .. ...| ... |. | |.. ... | | ... .. .|. . .|   .||| .||...  .|...  ||..    . || ||||||||||| .
qyWPe.tedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvl

VAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
...| .|...   ...  |   | .|. ||  .|   ||  . . .
illetalalieaaepvypldivrtmrdqramlvqtasqykfvCeai

subfamily_PTPN9_pd Subfamily PTPN9 146-378 4.9e-58 191.5 In-house 37-290 (297) alignment
Range on Protein: 146-378
Range on HMM: 37-290/297.0
KIFDANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAG
    || .||||.||.| | ||| |.        |||.||.|.| .    || |||.   || ||||||   ..  |||   |.| |. ||.||.|.. .
sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

EAMTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS-----------------GPVTVHCSAGIG
... ||  ..  ..|...  .  .|.| ..||.....  . |    ||||  ||.|...|| .|  || .                   |. ||||||||
ssaefgdlsv.snveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
|||||.... ||. | .   .|.  | . ||. || |||.. ||.   . ...| 
rtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 147-377 1.8e-57 189.9 In-house 52-289 (298) alignment
Range on Protein: 147-377
Range on HMM: 52-289/298.0
IFDANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKagE
  ..|  |||| |..  | .||.|..     ..||| | .... .   .||.||.   .|| ||||||.. . . |||| .. | .| |. .|.|..  .
rkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..g

AMTFGAWTILCsLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT---ASG--PVTVHCSAGIGRTGTFVAIEACLQ
. |.|  |.   |.... |..|.|.| | . .. ||. ...||  ||||..||. . ..| .|  ||.    .|  ||.|.||||.||.|||.||.. |.
ketygeitvsl.lskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvle

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
 .   . .|.. . ..||..|.|..|   ||. . .. ...
rvkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 150-377 8.5e-57 187.4 In-house 46-278 (288) alignment
Range on Protein: 150-377
Range on HMM: 46-278/288.0
ANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkAGEAMT
 | .||||....  | .|| | .   . . ||| |.|..| .    .| |||  |.|| |||..|  .||  |||| |..|.|| || .|.|. |..   
vnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPd.adkpkn

FGAWTILCSlEDDKDANIIKRTLSVRnvDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTD
.|  |.    |. .  ....|.| .    ...|  ..... ..|||  ||.|.. || .|..| .|    .||..||||||.||||||.|..| .. .  
yGsvtvtlv.eskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidavee

GKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
 . .|..||   ||..||  .|.  ||. . ..|.. 
edyiDvagtvaklRkqRallvqtlkqYefiyevllsl

subfamily_PTPN12_pd Subfamily PTPN12 149-375 3.7e-56 185.2 In-house 38-274 (290) alignment
Range on Protein: 149-375
Range on HMM: 38-274/290.0
DANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
. | .||||||..  | .|| ||      . ||| ||...| .    .| .||  ..|. |||||. ....  .||.|...| || ||..|.||. .|..
eenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeel

TFGAWTILCSLEDDKDANIIKRTLSVRNVdnGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILT
.||. .. .. |.  | ... ||| |..   ....... .| ..|||. ||.|.  ||...  ||.     . |. ||||||.||||| .||.   ..| 
efgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellk

DGKE---LDLLGTCRALRNSRAGSIQVDIQYMALVQILI
..|    ||.    . ||. ||  .|   ||  . . ..
aekipeeldvfdlvlelrkqraalvqtkeqyelvykava

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 149-378 1.9e-55 182.6 In-house 53-289 (305) alignment
Range on Protein: 149-378
Range on HMM: 53-289/305.0
DANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGLNAP---FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTF
| . |||||.|| |.| . | |..    ||||||||     |   || .||    |. .|| ||.. |   |||||  .| || |||||.|   || ...
diaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

GAWTILCS----LEDDKDANIIKRTLSVRNvDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDG
 .  ..         ..||.|   .| .     ...  ..||.   |||| ||   .. | .|  .| .  |. |||||||||||| ||||  |. ... 
ksgivvenvsgskpmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaen

KELDLL-GTCRALRNSRAGSIQVDIQYMALVQILINYG
|.   .    .|||. || ||| |.||. . ....|| 
kpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 147-396 3.4e-55 182.3 In-house 42-299 (318) alignment
Range on Protein: 147-396
Range on HMM: 42-299/318.0
IFDANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAge
. ..| .|||| ...  | ||| |..     . ||| |||..| ..   .| .|.  . |. ||||||   ..| |||| ...| ||||...|.|.|   
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskg..

AMTFGAWTILCSlEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTAS-----GPVTVHCSAGIGRTGTFVAIEACLQ
....|. ..  . |. . .. . |...|.. .. .. . .  |  ||||. ||.|.. || ..  |..|      ||..||||||.||||.|.|... |.
srsygklvvelk.eevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdille

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD-NGYWDDSDLDDRVELL
 . . . .|...| . ||. |   .|.. ||  . ..|... .  . . | ||| .|.. |
rikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirel

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 107-386 2e-54 179.4 In-house 4-295 (305) alignment
Range on Protein: 107-386
Range on HMM: 4-295/305.0
VQKKVFFKFASDAVKKNPPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGLNAP--FILTQGATAATVID
 |||   ||   ...| |     ||..  .    . |.      .  ||||||| | |  || |      .|||||||     |  || ||     |  |
qqkkqilkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcad

FWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAW----------TILCSLEDDKDANIIKRTLSVRNVdNGKEHILKHLHTKSWPDRCVP
|| | .  |  .| |||...| |  ||..|.. | .. ..|             .   ....| .|.. .  | .     .| .  .| |   |||| ||
fwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegp.gekarkvthyhwidwpdrgvp

NSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLG-TCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWDD
 . .|.| .|   |.. ||..|||||||||||. | .|  |. |  |. ..      . .|. |  ||| | ||. . |...|| ....  |.
aadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkllde

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 140-377 8e-54 177.7 In-house 30-276 (307) alignment
Range on Protein: 140-377
Range on HMM: 30-276/307.0
GQPMERKIFDANPTKNRYKDVVCNDITRVILS-DGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYP
 . .  . |.||. ||||.|| | | .|...  ||   |||||||.     |  || .||   .|. .|| |..  |   ..|||.|.| .| || ||.|
pegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywp

EKAGEAMTFGAWTILCSLED------DKDANIIKRTlSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVA
 . |. ..||  .   |...        | ..|. | ... .  .|   ..||  . |||| ||.  .. . .|  ||    || ||||||.||.|| ||
leegqklvfgeapntisvanlgakklapdedlinvt.tlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtiva

IEACLQILTDGKE-LDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
|    . . .|..  |.    . ||. |  .|| ..||. | ..|..|
islvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 140-377 1.5e-53 176.9 In-house 35-282 (305) alignment
Range on Protein: 140-377
Range on HMM: 35-282/305.0
GQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQY
..... .  .|| .|||.|...  |  |.||.   .    ||| |.||.| .    .|..||    || ||||..|..|.  ||||....|.|| || ||
eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqY

YPEKAGEAMTFGAWTILCSLEdDKDANIIKRTLSVRNV-DNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA---S-G-PVTVHCSAGIGRTGTF
.||. .| . ||  ..  . |  . .. |.| |.. .  .. ... . ...  .|||  ||... .||...  |. .   . | |..||||||.||||.|
Wpesktekkefgefsvelkse.ktasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvf

VAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
.|..  |. |   ...|. .  ..||..| . .|   ||. | ..| ..
iavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 149-393 2.2e-53 176.4 In-house 46-299 (319) alignment
Range on Protein: 149-393
Range on HMM: 46-299/319.0
DANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKagEAM
. | .||||....  | |||.||.     . ||| |....| .    || ||.  . |. |||||| . ..  .|||... | .| |. .|.||.  . .
eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee..nfe

TFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGK-EHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLQI
..| ...   .|... ...|.| |....  .      .|| . ..|||  ||.....|| .|  .|       |||..||||||.||||||....| |. 
eyGrliv.tleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamler

LTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNG-YWDDSDLDDRV
.     ||.  | . ||  |   .|   ||  . ..|... .      .  || ||.
vkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

subfamily_PTPRA_pd Subfamily PTPRA 148-378 1.1e-52 174.0 In-house 55-295 (330) alignment
Range on Protein: 148-378
Range on HMM: 55-295/330.0
FDANPTKNRYKDVVCNDITRVILSD--G-GDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgeA
 . |  |||. ... .| .|||||   |  . ||| | ...| .    || .||  . || |||||.   |.| |||| |. |  . |||||.|..   .
keenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeG..l

MTFGAWTIlcSLEDDKD-ANIIKRTLSVRNVDNG----KEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----ASGPVTVHCSAGIGRTGTFVAIEA
.|.|  ..  ..||..   ..  | . |... ..    |. ... .| .||||  ||  .. .|..|  |..     .||..||||||.||||||....|
vtyGnirv..evedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivlda

CLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
 |. .   . .|. .. . ||. |.  .| | ||  . ..| .| 
vlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN6_pd Subfamily PTPN6 150-380 2.5e-52 172.8 In-house 53-299 (306) alignment
Range on Protein: 150-380
Range on HMM: 53-299/306.0
ANPTKNRYKDVVCNDITRVIL-SDGGDG-DYIHANYVN----GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
 | .||||| ..  | ||||| ...  | ||| |||..    | .. .| |||.  .|| ||||||.  ..  |||. . .| || |||.|.|..  . .
enkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

tFGAWTILCSLEdDKDANIIKRTLSVRN-VDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEAC
 .|  .. .  | .. |. | |.||| .  ....|. . ..| |||||  ||... |.| .|  |..         .||. |||||||||||||. |.. 
.yGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDil

LQILTDG---KELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
|....      ..|.  . . .|. | | .|.. ||  . ... .| . 
lkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 150-377 5.3e-52 171.5 In-house 8-241 (250) alignment
Range on Protein: 150-377
Range on HMM: 8-241/250.0
ANPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAkCAQYYPEKagEAMT
.|  |||| |..  | .||.|       . ||| | ...| .    || |||   ||. ||||||.. |.. |||| .. | .|  . ||.| .  .| .
qnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve..kaek

FGAWTILcSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLQILT
.|  |.   |.... |...||.| . .  . .| |...||  .|||..||. . | | .|  |..      ..|| |.||||.||.|.|.||.| |. | 
yGdvtvs.llskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
  | .|.    ..||. | ....   ||. . .|....
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_PTPN13_pd Subfamily PTPN13 119-375 9.6e-52 170.9 In-house 7-266 (273) alignment
Range on Protein: 119-375
Range on HMM: 7-266/273.0
AVKKNPPEYSVEFMTKVKPYPGQPMERKifDANPTKNRYKDVVCNDITRVILSDGGDgdYIHANYVNGL----NAPFILTQGATAATVIDFWRMVVHTKT
..... |.   . . ..||     . .|  ..| .||||..|.  | |||.|.| |   || |....      .  .|..||    || |||.||   |.
kldqqqPaeefkelrelkpldtcevgkk..kenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqka

AYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVR---TAS
  |.|.    |.|| || .|.||.... ..      .  |.  |  .   |.| |.... |. . . ||.  .|||  ||.|.. ||...  ||   | .
eviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtda

GPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
||. |||||||||.||...|.. |...   ||.|.  . | ||. | | .| . ||.   ....
gPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykail

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 142-380 1.4e-51 170.2 In-house 20-270 (274) alignment
Range on Protein: 142-380
Range on HMM: 20-270/274.0
PMERKIFDaNPTKNRYKDVVCNDITRVIL----SDGGDGDYIHANYVNGLN---APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQY
. | ..|  . ||||||... |. .||.|    |.  | .|| |||. | .     .. |||  . || |||||. ....  |||| .. |  ..|||.|
qeeldvfg.sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

YPEKAGE--AMTFGAWTILCSLEDDKDANIIkRTLSVRNVDNGKEhiLKHLHTKSWPDRCVPNSTMALLRMLYIVRTA-------SGPVTVHCSAGIGRT
.|.. .   . ..|   |  .   ...   . |.|..... . ..  .||    .|||. .|... .||...  |...        .|| ||||||||||
fPdaedyeiserygdveikvekiverndysv.rklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrt

GTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
| |.||. ... | . . .|.|..   ||  | | .| . ||  . ..|. | | 
GcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 141-376 1.5e-51 170.1 In-house 31-274 (281) alignment
Range on Protein: 141-376
Range on HMM: 31-274/281.0
QPMERKIFDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYY
.. .    |.| .||||...|  | ||| .   ..  . ||| ||.|.|.  .. .| |||   |.. .||.||. .|   |||. . .| || || .|.
ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYW

PEKAgEAMTFGAWTILcSLEDDKDANIIKRTLSVrNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVA
|... .....|  |.  |..  . |. |.|.... . ..|..  ...|. ..|||  ||..|..||     |.         |. .|||||.|||||..|
Pddn.selkygdvtvk.staeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyia

IEACLQIL-TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
..  .. . .. .|||.  . . ||..|   .|  .||  . .....
lDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 146-376 5.3e-51 168.4 In-house 38-269 (288) alignment
Range on Protein: 146-376
Range on HMM: 38-269/288.0
KIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
. | ||||..||... . ||||| |||  |  ||.|| |   .    .| .|    .|.  .|.|....   |||||||..| || | |.|.| | ||..
dsfianptrdryenlprcditrvklsddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

TFGAWtilCSLEDDKDANiIKRTLSV---RNVDNGKEHI-LKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT
 .|     |.   .| |. |.....|   |.  .|.|.. .|.|| . |.| .||.. .. ||.| ....   |. ||.|||.|||||.. |   |. | 
rigrl...ctvvkkkrad.idklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslr

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
    | .   .  ||..|  .||.  ||. . ... .
lddflgirsllaklreerfkaiqtemqylyvhrcvle

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 151-378 1.7e-50 166.5 In-house 20-264 (270) alignment
Range on Protein: 151-378
Range on HMM: 20-264/270.0
NPTKNRYKDVVCNDITRVILSDGG---DGDYIHANYVNGL---NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGE--A
... |||.|.. .  |||.|..        || ||||.|    .. .| ..| ...|. .||||....|.  |||. ...|.|. ||..|.|....|  .
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

MTFGAWTIlCSLEDDKDANIIKRTLSVRnvDNGKEHILKHLHTKSWPDRCVPNSTM------ALLRMLYIVR-----TAS-GPVTVHCSAGIGRTGTFVA
...|  .. ..|.. |.   |.. | ..  ..|.|. | | . ..|||. ||...        ||.||  ||     ..  .|. ||||||.|||||..|
ledgkikv.lalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlia

IEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
.. ....|   |..|.|   ..||. |   .|   ||  | . ...| 
lDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_PTPN23_pd Subfamily PTPN23 149-378 4.5e-49 161.8 In-house 41-280 (288) alignment
Range on Protein: 149-378
Range on HMM: 41-280/288.0
DANPTKNRYKDVVCNDITRVILSdGGDGDYIHANYVNGLNA---PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTF
  ...|||..|..  | .|| |  |.  ||| | .|..| .   .|| ||.  . |. |||.||.. |.  |||| .  | || |...|.||. ||...|
klyseknrsrdilPyDhnRvklr.gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkf

GAWTILCSLEDDKDaNIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEACLQI
|. .. .. . . . . ..|.|...  |. . . ..||...|||.  ||.|   ||..|  |..        .  |. ||||||.||||.|  . | .. 
gdlsvtlksvrete.thvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

LTDGKEL-DLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
|. |. | |..   . ||. |  ..|   |.  . .. ... 
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_PTPRK_pd Subfamily PTPRK 149-372 9.9e-49 160.8 In-house 41-271 (314) alignment
Range on Protein: 149-372
Range on HMM: 41-271/314.0
DANPTKNRYKDVVCNDITRVILSD--GG-DGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgeaM
| | .|||..|..  | .||.|    |  . ||| |..... . |  || |||    || ||||.| . ..| |||| |..| |. || .|.||..   .
denreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedt...e

TFGAWTILCsLEDDKDANIIKRTLSVRNVDNGKE--HILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----ASGPVTVHCSAGIGRTGTFVAIEACLQI
..|   . . .| . .|....|...|...  |.|  .......  .|||  ||.|  .||...  | .      |.. |||||| ||||||.||.  |..
vygdikvel.vetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldm

LTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
.   . .|.  . ..||...   ...  ||. . .
ieregvvdvfnavktlrsrkvnmveteeqykfiyd

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-381 1.6e-48 159.9 In-house 37-280 (287) alignment
Range on Protein: 150-381
Range on HMM: 37-280/287.0
ANPTKNRYKDVVCNDITRVILSDGGD--GDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKaGEAMTF
|.  |||| ||.  | |||.||  |.   ||| |||| . .    || .||  |||| ||||.|..|..| ....   .|... || .|.||.    |  
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrv

GAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV-------RTAS--GPVTVHCSAGIGRTGTFVAIEACLQ
| ...     | |. .   |.| . ...  . ...| |.  ||||. .. ....|.|.   |       | ||  ||. ||...||||.|...|. ....
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDN
 | |  ..|   .   ||. ||. .|  .|.  |.. |. | | |
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 149-372 4.6e-48 158.6 In-house 41-270 (515) alignment
Range on Protein: 149-372
Range on HMM: 41-270/515.0
DANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
. | .|||||...  | .||.|    |  . ||. | |......   .| .||   |.| ||||.|.. ... |.|. .  |. | ||..|.|.| |...
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

TFGAWTI-LCSLEDdkDANIIKRTLSVRNVDNgkEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASG----PVTVHCSAGIGRTGTFVAIEACLQIL
 ||   . | |||   ... |||.| |   |.   . .   | . |||. ||. | .||...  |..  |    |. .|||||.|||| ...|. ..   
kfGsikvelvslea..ctggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
 ... .|.. . . .|. |   .| . ||  . .
kttrmvdvfnfvtnirqkrpylvqtqeqyafiyg

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 133-382 6.7e-48 158.1 In-house 17-274 (285) alignment
Range on Protein: 133-382
Range on HMM: 17-274/285.0
TKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDgGDGDYIHANYVN--GL-NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKA
 |.| |         ..|||  ||| || | . |||.| .  | |||||...   |  .. .| |||    |. |||.|. . | ||..||| ..| |  
dkikgymppnctytayeanpdlnryadvrcieetrvvlkn.hdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggve

KCAQYYPEKAGEAMTFGAWTI-LCSLEDDKDANIIKRTLSVRNVDNGKEH--ILKHLHTKSWPDRCVPNSTMALLRMLYI---VRTASGPVTVHCSAGIG
||| ||||| || . || . | |   ...  |  |  .|.| | ..       ..|..   |||.  |. .  .. .      |     |. ||||||.|
kcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvg

RTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNG
|| ||| |. .   . .  ....|   | .|  |  ..|  .|.. |  .|..|   .|
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigeg

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 148-374 8e-48 157.9 In-house 41-273 (315) alignment
Range on Protein: 148-374
Range on HMM: 41-273/315.0
FDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEA
 . | .|||||...  | .||.|    |  | ||| | |.....    .| .||   |.| ||||||...|.. |||. .  |. | ||.||.|.. ...
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

MTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNgkEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASG----PVTVHCSAGIGRTGTFVAIEACLQIL
. ||.. .   |. . |.. ..| | .|. ..   . .   . . |||. |.. | .||...  |..  |    .. ||||||.|||| ...|. ... .
vefGsikv.ellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqi

TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
 ... .|.. . . ||. |   .| . .|  . ...
krtrsvdvfnfvknlrakrpylvqteeeyafiydav

subfamily_PTPN1_pd Subfamily PTPN1 148-370 1.1e-47 157.2 In-house 29-267 (290) alignment
Range on Protein: 148-370
Range on HMM: 29-267/290.0
FDANPTKNRYKDVVCNDITRVILSDGgDGDYIHANYVN--GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAG-EAMT
...| ..|||.||   | .|..| .. | ||| |. |.   ..  .|||||  . ||  ||.|| . |.  .||| .|.| .. |||||.|..   ....
lpenrnlnryrdvspydhsriklera.dndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekell

FG-AWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA------SGPVTVHCSAGIGRTGTFVAIEACLQI
.  .   .  .. ..  . . |.| . |.   . . . | |  .|||  ||.|  |.|..|. || .       ||. .||||||||.|||. ...||  
ledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvl

LTDGKE---LDLLGTCRALRNSRAGSIQVDIQ----YMAL
. . ..   .|.  .  .||. | | ||   |    |.|.
iekkddlssvdikkvllelrkyrlGliqtadqlrfsylai

subfamily_PTPRG_pd Subfamily PTPRG 149-376 1.7e-47 156.9 In-house 45-285 (563) alignment
Range on Protein: 149-376
Range on HMM: 45-285/563.0
DANPTKNRYKDVVCNDITRVILSD--GGDG--DYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkaGEA
  |  |||| ..|  | .|| ||.  | ..  ||| |||..| .    || |||. . |. |||||.   ..| |||. .. |.|. || .|.|.   |.
penkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..des

MTFGAWTILCSlEDDKDANIIKRTLSVRN--VDNGK----EHILKHLHTKSWPDRCVPNSTMALLRML----YIVRTASGPVTVHCSAGIGRTGTFVAIE
.|.|| ..    | .. |   .|||...|  ....|    |.  .. |  .||| .||....  | .     .  ... ||..||||||.|||||.....
etygalqvtli.eeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivld

ACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
. |. . . .  ...|. . .|  |   .|   ||. | ..|..
tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalle

subfamily_Ptp69D_pd Subfamily Ptp69D 149-391 1.9e-47 156.9 In-house 46-300 (307) alignment
Range on Protein: 149-391
Range on HMM: 46-300/307.0
DANPTKNRYKDVVCNDITRVILSD---GGDGDYIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKagEAM
. |  ||||.|..  | |||.|.      | ||| |....|   .  ||  |.   ||. |||||.   .   |||| .. |  ..|||.|.|.   . .
kenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..dev

TFGAWTILCSlEDDKDANIIKRTLSVRNVDN------GKEHILKHlHTKSWPDRCVPNSTMALLRMLYIV----RTASGPVTVHCSAGIGRTGTFVAIEA
 .|   . .  . .|  . |.|.|.| ....       . ..... | ..|.|  ||... .||.... |    ..  .|..|||||| ||.|.|||.. 
qygdilvklv.seekhsdyiiReldvskkkeesgevedsrkvvqy.hytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvalds

CLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK-DNGYWDDSDLDD
 || |   ...|.  | . ||. |   .|   ||. | . |..| .  .   |  ||.|
llqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddled

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 150-375 3e-47 156.1 In-house 48-276 (315) alignment
Range on Protein: 150-375
Range on HMM: 48-276/315.0
ANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKageAMT
 |  |||| ...  | .|| |       . ||. ||...| | .  .| .||  .|.| ||||.| . . . |||| ...|. | |. .|.|.|    ..
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kvi

FGAWTILCSLEdDKDANIIKRTLSVRNVDNGKEHIlkHLHTKSWPDRCVPNSTMALLRMLYIVR---T-ASGPVTVHCSAGIGRTGTFVAIEACLQILTD
.|  |.    | ..  ..  |||||   || .| .   ||  ||||  ||..|..|. .   |.   | . |.. ||||||.||||||....| |. .  
yGkitvtrkse.evnteytvrtlsvvfgdnirevv..qlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaea

GKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
 . .|.   .. .|. | . .||  ||  . ..|.
enaidvynfitgvrqnrikmvqvaeqyqfiydall

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 151-375 1.1e-46 154.3 In-house 51-281 (297) alignment
Range on Protein: 151-375
Range on HMM: 51-281/297.0
NPTKNRYKDVVCNDITRVILSDGGD---GDYIHANYVNGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKaKCAQYYPEKAgeAMTFGA
|  |.|||...  |  ||.|   .|    ||. | .|.| .  .| ||    ||| |||.||.. ... |||| .  |  | |||.|...|.   .||| 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg..vttfGd

WTILCSLEDdKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPN--STMALLRMLYIVR-----TASGPVTVHCSAGIGRTGTFVAIEACLQILTD
 ... .  . .    |||.|.|.. .. .....|  .  .|||. |..  |. .|| ..  ||     .|.||. |||.||.|||| ...|. ..    .
vsvvllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakr

GKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
 ||.|..|. . ||..|   .| . ||  . ....
ekevdifglvkklrqerpylvqtkeqykfvyvavl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 142-378 2.3e-46 153.0 In-house 37-283 (290) alignment
Range on Protein: 142-378
Range on HMM: 37-283/290.0
PMERKIFDANPTKNRYKDVVCNDITRVILS-DGGDGD----YIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQY
 .....   | ..||....| .|  |..|   .|. |    ||.| |..|   .  .|.||| .  |..|||..... |.. ||||....|.|| || ||
tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqY

YPEKaGEAMtFGAWTILCSLEDDKDaNIIKRTLSVRNVDN-GKEHILKHLHTKSWPDRC-VPNSTMALLRMLYIVR----TASGPVTVHCSAGIGRTGTF
.|.. . .. .| ..|  . |   . ..|.|.|.|.| .. |......... ..|..   |.| .  || .  ...    .  ... ||||...||...|
Wpds.dtka.ygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavf

VAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
.|..  ..        |..   . .|  . ||.|   ||  ..||...| 
caaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 112-377 1.6e-44 147.0 In-house 7-277 (287) alignment
Range on Protein: 112-377
Range on HMM: 7-277/287.0
FFKFASDAVKKNPPEYSVEFMTKVK-PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSdGGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRM
| .|. .  .|.  ...  |..  .     . .  .|   |  |||.....  |  ||.|  | . ||| | ...| .    ||....  . |. .||..
fgefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfWkl

VVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGeaMTFGAWTILCSLEDdKDANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRC-VPNSTMALLRMLYI
. . .   |||||. .|. . .| ||.||..   ...| ..|    |. . |. |.|.| |.| . .|... .|  .  .|...  |..    || .   
iddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieem

VRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
..|    . ... ||||...||...|.|..  ..       .|..   .  |  . ||.|   ||. ...|...|
yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivley

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 150-378 1.6e-44 146.7 In-house 36-269 (281) alignment
Range on Protein: 150-378
Range on HMM: 36-269/281.0
ANPTKNRYKDVVCNDITRVILS----DGGDGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAM
 |  |||| .. | ||.|| |     .    |||||||.    |.  .|||||    |  |||||. . .|. |||||...|  . |||.|.| .|  ..
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahccl

TFGAWTIlcSLEDDKdANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGK-
 |   ..  | ||    |    |  .    .|. ... |   | |||  ||.|.  .|..|  .|. | |  .|||||.||.||..|.| .|| .     
qfdklsv..syedst.vnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshft

ELDLLGTCRALRN-SRAGSIQVDIQYMALVQILINYG
  |.      ||   || |.|   ||| . ..|...|
lpdikqivshlrvtgraasvqtlqqymliwkvlldfg

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 147-377 1.6e-43 144.1 In-house 44-287 (325) alignment
Range on Protein: 147-377
Range on HMM: 44-287/325.0
IFDANPTKNRYKDVVCNDITRVILS---DGGDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMlCEVMEDGKAKCAQYYPEKAGE
   .|  |||.|.||  | .||.|    | .. ||| |.|..       |. .|   .||. |.||.|.  ... .|.  .... || .||.|.|.. |.
mkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywpkemgk

AMTFGAWTI-LCSLEDDkdANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV-------RT---ASGPVTVHCSAGIGRTGTFVA
. |||.  . | ..|.   .. ..| | |..|..|.   .| .. .||.|  |..   .|. .| .|       ..   ||.|. ||||||.||||.|..
sktfGglevklrtieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfis

IEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
. . |. . .  ..|..|  . ||. |   ..   ||. . . |...
lysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 147-379 5.9e-41 135.0 In-house 48-291 (310) alignment
Range on Protein: 147-379
Range on HMM: 48-291/310.0
IFDANPTKNRYKDVVCNDITRVILS--DGGDGDYIHANYV--NGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkAGEA
 .  .  |||| |||| | .|| |       .||||||||  | | . || .||    |.||||||.   ..  |..|| |.|.|. ||  |.|   | .
aykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvt

MTFGAWTILCSLEDDKDANIIKR--TLSVRNVD------NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEAC
 |.|   .    |  .. .| .   |.   ||       | ||  .. ..   |||| ||.     .    . .   ||. ||||||..|... ||..  
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklk

LQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
.. |  |...|.      |..|||  || ..||. . .. | . .
idkldrglkvdaeevktellksraiciqtelqyliidrvriifar

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 126-376 1.6e-40 134.4 In-house 35-289 (319) alignment
Range on Protein: 126-376
Range on HMM: 35-289/319.0
EYSVEFMTKVK-PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILS--DGGD-GDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVM
.. |||    | . ..  ..    | |  |||. ...  | ..| |   .| .  ||| | .|.|   .  .| .||    |. |||||.   ... ||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LCevmedgKAKCAQYYPEKAGEAMTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGKEHIlKHLHTKSWPDRCVPNSTMALLRMLYIVR------TASGP
|       | ||.||.| |. .    .   .  |.|. ..  . .  ||     ... .| .  | . |||  ||.... |.|..  ||          .
lt......kdkcsqywplkivikeerfkvkv.dsveetaeyvvrdielsedgkekdirki.tqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhran

VTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
. ||||||.||||....... |. . . | .|.  . | ||. |   .|  .||. .   |..
ivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 132-372 5.8e-40 131.9 In-house 15-260 (283) alignment
Range on Protein: 132-372
Range on HMM: 15-260/283.0
MTKVKpYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVN-----GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMED
. ..   | .. . .  | |..|||....|  |  || |      ||| | ..        .  .| .|.    ||.|||.|| . | . |||| ...||
lkrls.vpdldadiasadenkrknrnqeivpadqwrvelksesr.dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqed

GKAKCAQYYPEKAgeAMTFGAWTILCSLEDDKDAnIIKRTLSVRNVDNGKEHI-LKHLHTKSWpDRCVPNSTMALLRMLYIV-----RTASGPVTVHCSA
 . ||.||.|..   .. .| .|.    |  ...  |.. | .|.    |. . | |     |   . ... .  |  .  |     .   ||. ||||.
lrikCsqyWPkrG..sedyGeftvtlrkettsns.fiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPivvhCst

GIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
|||||..|.|. | .. .     .|.  . . .|. | . .|   ||. . .
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhe

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 137-376 1.1e-39 131.6 In-house 11-253 (284) alignment
Range on Protein: 137-376
Range on HMM: 11-253/284.0
PYPGQPMERKIFDANPTKNRYKDVVCNDITRVILS--DGGD-GDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCevmedgKAKC
. .|  ..    | |  |||. ...  | ..| |   .| .  ||| | ...|   .  .| |||    |. |||||.   ... ||.|       | ||
gvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkc

AQYYPEKAGEAMTFGAWTIlCSLEDDKDANIIKRTLSVRNVDNGKEHIlKHLHTKSWPDRCVPNSTMALLRMLYIVR------TASGPVTVHCSAGIGRT
.||.| |. .    .   .  |.|. ..  . .  ||     ... .| .  | . |||  ||.... |.|..  ||          .. ||||||.|||
sqywplkivikeerfkvkv.dsveeseeyvvrdielsedgkekdirki.rqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

GTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
|....... |. . . | .|.  . | ||. |   .|  .||. .   |..
gvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 151-374 5.1e-39 128.9 In-house 3-235 (237) alignment
Range on Protein: 151-374
Range on HMM: 3-235/237.0
NPTKNRYKDVVCNDITRVILSD-GGDGDYIHANYVNGLN---APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAgEAMTFG
|  |||| ..|. | .||.|   |.. ||| |.|..|..     .| .||   ..  |||.||   | . ||||  ..|  . || .|.|.   .  ..|
nkiknrygnivaydhsrvvlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstd.qpaayg

AWTI-LCSLEDDKDANIIKRTLSVRNVDNGKeHILKHLHTKSWPDRCVPNSTMALLRMLY--IVRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILT
 .|. |.  |.  |  .   .||.|   ..   ...  .  ||||| ||. | ||||.    | |.     |||  .|||||.|||| |. |.| |.   
vltvslkkkeefsdytvrslllskrltlkev.rlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
. | .|.     .. . |   ||.  ||. . | .
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 153-367 7.8e-39 128.2 In-house 52-270 (301) alignment
Range on Protein: 153-367
Range on HMM: 52-270/301.0
TKNRYKDVVCNDITRVILSDGGDGDYIHANYVN--GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTI
 |.||. | |.  | | . . |    ||||...  |    || |||   .|  ||| |.|. .   ||||.. .|. . ||..|.| | .| .  | ..|
dkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfki

LCSLED-DKDANIIKRTLSVRNVD-NGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLG
    ..   . .|.|||| |..   . . . . |   ..|.|| ||.| . |  .. .|. .  |. |||||||||. .|.. |   . .   ....|  
kiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptielte

TCRALRNSRAGSIQVDIQY
. . ||. |  ..|   | 
alkhlrehrwngvqtnsql

0041856 (Phosphotyrosine protein) phosphatases II 151-376 3.7e-38 126.3 In-house 1-169 (182) alignment
Range on Protein: 151-376
Range on HMM: 1-169/182.0
NPTKNRYKDVVCNDITRvilsdggDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCevmedgkakCAQYYPekageamtfgaw
| .||||.|....| .|       | |||.||.. |   .  ||.||| .  || ||.||. . .  .||.|.         . .|.|            
nldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

tilcsleddkdaniikrtlsvrnvdNGKEHILKHLHTKSWPDRCVPNsTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQIltdgkELDLLG
                         .  |.   ...  .||| .||. .  ||... .|.  .||| ||||||.|||||.||.  ...      ...|  
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

TCRALRNSRAGSIQVDIQYMALVQILIN
. . .|. | |...   ||  | ..|  
avklvrsrRpgmvitpnqyfflqlalle

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 166-367 8.6e-38 125.1 In-house 33-248 (290) alignment
Range on Protein: 166-367
Range on HMM: 33-248/290.0
TRVILSDGGD---GDYIHANYVNG-LNAPFILTQ-------GATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKA----KCAQYYPEKAGEAMTFGAWTI
|||.| . |     ||||||.|    .  .||||          ..|. .|| |.   |   .|||||..|  .      ||.|.||..|| ..|.  |.
trvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltv

LCsLEDDKDANIIKRTLSVrNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT-DGKELDLLGT
 |  .  |. ....|.| | . |...|. ..|   |.| .. |...|  || ..  |..   || |||  || |  .. ||.   | .    ... |   
kC.kskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledv

CRALRNSRAGSIQVDIQY
  |||. ||  |. ....
lkalrkqralaitsalel

0051429 (Phosphotyrosine protein) phosphatases II 176-386 1.8e-37 124.8 In-house 4-256 (272) alignment
Range on Protein: 176-386
Range on HMM: 4-256/272.0
GDYIHANYVNGLnAP------FILTQGATAATVIDFWRMvVHTKTAYIVMLCEVMEDGKAKCAQYYP----------EKAGEAMTFGAWTILCSLEDDKD
..||.|..|.|.         .....| . .|. ||||.  . .  .||.|....| |. || .| |          . . . ...||... .  |  ..
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

ANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTmaLLRMLYIVRTaSGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELD--------LLGTCR
  |. . | .. ...|. . . |||  .|||..|| ..  ||..| .... .||| ||||||..||||.||.  .|. ...   .|        |... .
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeave

ALRNSRAGSIQVDIQYMALVQILINY-----------------------GKDNGYWDD
 ||  |.|..| . ||. | ..|...                       |  .||  |
elraqrpgavqteeqylflyeallellrsllsvraeyllaaldaideeyGsvegYLrd

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 154-385 2.8e-37 123.1 In-house 46-283 (312) alignment
Range on Protein: 154-385
Range on HMM: 46-283/312.0
KNRYKDVVCNDITRVILSdGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGE--AMTFGAWT
 ||| .. | |  |  |. | .  |||||.|.    |  |. |||.   |.  ||....   .. |..|| ..|||  |||.|  .  |         .|
lnrypniqcwdrgrftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyt

ILCS---LEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDL
  |.   .      .| .| | |     |.|  |.|    ||||  .|.|  . ||.|  |.    ||  |||||.|||||.. ||. .  |   .  ..
eycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnv

LGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGYWD
  .   ||. || |..|  ||.  .......   .| . 
kdsfvllrkdrarsvrvfpqyvyalrcvleflyskglyk

subfamily_PTPN14_pd Subfamily PTPN14 148-379 5.4e-37 122.4 In-house 46-297 (300) alignment
Range on Protein: 148-379
Range on HMM: 46-297/300.0
FDANPTKNRYKDVVCNDITRVILSDG--GDGDYIHANY----VNGLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEK--A
 . |  |||.|||.  . .|| ||     . .|| |      | | .  .| .||    || |||.||  .... |||| |  |||| |. .|.|..   
lpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPklesk

GEAMTFGAWTILCSLEDDKDAnIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMAL---LRMLYIVRTA----------SGPVTVHCSAGIGRTG
 . ..|| . .   . .| |. .| ..| .. .  ..|  . ||  . |||. ||.        |...  || .          . || ||||||.||||
kktvefgkfkvttkfsedsds.vittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtG

TFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
  .  .  .. |  ..|.|.  . . ||. |   .|   ||  . ..||.| |
vlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 151-374 9.6e-36 118.1 In-house 48-275 (439) alignment
Range on Protein: 151-374
Range on HMM: 48-275/439.0
NPTKNRYKDVVCNDITRVILS---DGGDGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKakcaqYYPEKAgeAMTF
. ||||||||.  | |||.|          || |||..|   .  .| ||| .  |. ||||.|.. ||. ||||....|  |     |.| .|   . .
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsda..evcy

GAWTILCSLEDDKDANIIkRTLSVR-NVDN-GKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA-----SGPVTVHCSAGIGRTGTFVAIEACLQIL
|  .. .  . .    .| | . |  . |.  ||. . ..|  .|||. ||  .  .| .|  . .|      ||| ||||||.||||| .|.. .|. |
gdiavrvdrnielpnyvi.rgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeql

TDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
   ...|. |  . ||. |   .|   ||. . . .
klenkvdikgivkvlrkqrkqmvqalcqyvfiynav

subfamily_CG7180_pd Subfamily CG7180 150-376 2.7e-35 116.5 In-house 41-288 (296) alignment
Range on Protein: 150-376
Range on HMM: 41-288/296.0
ANPTKNRYKDVVCNDITRVILSD--G-GDGDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKaKCAQYYPEKAgeAMT
 |  |||. .||  | .||.|.   |  . ||| | ||...   . .| |.. .  || .|||.|   ..  .|.|.....  | .. .|.|.|.     
enreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keq

FGAWTiLCSLEDDKDANIIKRTLSVRNV----------DNGKEHILKHLHTKSWPD-RCVPNSTMALLRMLYIVRT---------ASGPVTVHCSAGIGR
.|    .  .| .. ||. .||. .              . .. |.|... . |.    || || ||. ..  ||.           ||| |..| | .|
ygeif.veiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasR

TGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILIN
.| ..||.|.|. .   .|.|. .  . ||.|| . ..   .|. . ..| .
sGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 151-370 1.1e-34 114.7 In-house 8-233 (239) alignment
Range on Protein: 151-370
Range on HMM: 8-233/239.0
NPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVN---GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMT
| .|||| ..|  | .||.|   |.    ||| |.|.    |    .| |||. ...  |||||. . . . ||||  ..|  | || ||.|. . .   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

FGawTILCslEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTD
.     |   . .  |. | ||. . .| . .|. . . |   |||. ||. . |.| .   .       . |  .|||||.||||.|. |.| |.    
lr..vtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

GKELDLLGTCRALRNSRAGSIQVDIQYMAL
 | .|..   .|.|. |   .|   ||. .
qktvdifnyvkairedrphmvqtseqyvfi

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 151-370 1.1e-34 114.6 In-house 7-232 (239) alignment
Range on Protein: 151-370
Range on HMM: 7-232/239.0
NPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVN---GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMT
| .|||| ..|  | .||.|   |.    ||| |.|.    |    .| |||. ...  |||||. . . . ||||  ..|  | || ||.|. . .   
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycn

FGawTILCslEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA----SGPVTVHCSAGIGRTGTFVAIEACLQILTD
.     |   . .  |. | ||. . .| . .|. . . |   |||. ||. . |.| .   .       . |  .|||||.||||.|. |.| |.    
lr..vtlr..ktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakk

GKELDLLGTCRALRNSRAGSIQVDIQYMAL
 | .|..   .|.|. |   .|   ||. .
qktvdifnyvkairedrphmvqtseqyvfi

0036282 (Phosphotyrosine protein) phosphatases II 176-372 4.1e-34 113.2 In-house 2-164 (174) alignment
Range on Protein: 176-372
Range on HMM: 2-164/174.0
GDYIHANYVNGLNAP--FILTQGATAatvidFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEkageamtfgawtilcsleddkdaniikrtlsvrnVD
 |||.|.....   .  .|..|| .|     ||.|. . .  ..|||.| .|.|. || .|.||                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..................................lr

NGKEHILKHLHTKSWPDRCVPNSTMaLLRMLYIVRTA-----SGPVTVHCSAGIGRTGTFVAIEACLQILTdGKELDLLGTCRALRNSRAGSIQVDIQYM
.  |.   ...   |||..||.... ||... .|..|     .||| ||||||.|||||.||.  .|. |   .  | | . |.||. | |..| . ||.
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyr

ALVQ
 | .
flyy

0046846 (Phosphotyrosine protein) phosphatases II 169-375 6.6e-34 112.6 In-house 5-170 (176) alignment
Range on Protein: 169-375
Range on HMM: 5-170/176.0
ILSDGGDGDYIHANYVNGlnAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMtfgawtilcsleddkdaniikrtls
.| ...| |||.||.. |  . .| ||| .  |. ||..|. . .  ..|.|.| .| |. ||..|.||  .. .                         
llgldldldyinanlilg..srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

vrnvdngkehilkHLHTKSWPDRCVPNStMALLRMLYIVRTAS---GPVTVHCSAGIGRTGTFVAIEaclqIL-TdGKELDLLGTCRALRNSRA-GSIQV
             . .   ||| .||..  .||..| ..|.|    ||| ||||||||||||.||.     .| . .| |... . . .|. |  |..| 
.............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llel.ekglsveealalvreqRplgavqt

DIQYMALVQILI
. ||  | . . 
peQyrflyefel

0049772 (Phosphotyrosine protein) phosphatases II 148-377 9.7e-34 112.9 In-house 43-279 (314) alignment
Range on Protein: 148-377
Range on HMM: 43-279/314.0
FDANPTKNRYKDVVCNDiTRVIL--SDGGDGDYIHANYVNGLnAPFILTQGATAATVIDF----------WRMVV--HTKTAYIVM--------------
. .|..||||.|... | .||||   .. . |||.|.||.|    || ||| .  ||.||          ||||.    .. .|||              
lflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLd

-------LCEVMEDGkakcaqyypekageamtfgawtilcSLEDDKDANIIKrtlsvrN-------VdngKEHILKHLHTkSWPDRCVPnSTMALLRMLY
       |..... |                         .. . .|   .|      .       .   .....|.|..  .|| ..| ..  ....| 
aAlgKtpllildgng.........................neptaadlellk......eelydpelf...erlgikylri.pvpDgsap.lledfdefle

IVRT--ASGPVTVHCSAGIGRTGTFVAIEACLQILtdgkELDLLGTCRALRNSRA-----GSIQVDIQYMALVQILINY
....  . ||| |||.||.|||||||..  ..  |     ..|  . . .|. |      |.|.  .||    ..| .|
fieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley

subfamily_egg_pd Subfamily egg 142-380 1.2e-32 107.9 In-house 31-272 (307) alignment
Range on Protein: 142-380
Range on HMM: 31-272/307.0
PMERKIFDANPTKNRYKDVVCNDITRVILS--DGG-DGDYIHANYVNG--LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDgkAKCAQYYP
.... . | | .| | | | |.| .|| |    |   .|.||||.|.|  |   |||.|     || ||||||   .  |||||    |    .|  |.|
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

EKAGEAMTF--GAWTILCSLEDDKdANIIKRTLSVRNVDNGKEHilKHLHTKSWPDRCVpNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEAC
    ... .  |.  | .   |.| |. . |   .. |   .|   ..|    .  . . .     ||.|  .| .| || |..  |. ...|.||||  
kaesdslvtvpGslrienlkvdsk.adplfrvtklklvGgddee..rflehwqgdvnns.sdvysplrvlrklrnlskpvvvqdilGvskaatlvaieia

LQILTDGK--ELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKD
|  |  |      .| ..  ||  |  |..  ..|. . .... . .|
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd

subfamily_PTPRN_pd Subfamily PTPRN 149-368 2.9e-32 106.6 In-house 54-282 (297) alignment
Range on Protein: 149-368
Range on HMM: 54-282/297.0
DANPTKNRYKDVVCNDITRVILSDG---GDGDYIHANYVNG---LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEa
. | .|||.|.|.  | .|| |..     . ||| |  .      .. .| |||  |.|| |||.|| .  .. ||.|... |.|  .|..|.|..  | 
eknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGse.

mTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLY----IVRTASGPVTVHCSAGIGRTGTFVAIEACLQIL
 ..... .    |     . . |.. ..|... .   .  .|  |||.. || |. .|| .        |  | |. ||||.| ||||....|.  |. |
.vyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrl

TDG-KELDLLGTCRALRNSRAGSIQVDIQYM
. | ||.|.  |   ||. |.| ..   |. 
lkGvkeidiaatlehlrdqrpglvktkdqfe

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 143-377 4.6e-32 105.9 In-house 32-292 (301) alignment
Range on Protein: 143-377
Range on HMM: 32-292/301.0
MERKIFDANPTKNRYKDVVCNDITRVILSDGG-----DGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYY
.. .. ..| . ||.|...  |  |.||.          .|| |.|..| .    || .||    |..||||.... |.. |||...  |. |.|| ||.
ctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqyw

PEKAGEAMTFGAWTILCSLEDDkDANIIKRTLSV-----------------RNVDngKEHILKHLHTKSWPDRCVPNSTMALLRML--YIVRT---ASGP
|.   |  .||  |.. . |     . . | |.|                 ..    . . .  |.  .||.  |       |. .   | |.     ||
pnseaeseefgpftvtlvneqv.yPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggp

VTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
| ||||....|.|......  |         |. .  .|.| |. | ..   ||. . ...  |
vvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy

0043147 (Phosphotyrosine protein) phosphatases II 175-371 5.7e-32 106.2 In-house 4-154 (172) alignment
Range on Protein: 175-371
Range on HMM: 4-154/172.0
DGDYIHANYVNGLNAP--FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVmedgkakcaqyypekageamtfgawtilcsleddkdaniikrtlsvRNV
. |||.|.|...   |  || ||| .  |. |||||. . .  .||.|.|                                                . 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..............................................lyd

DNGKEHILKHLHTKSWPDRCVPnSTMALLRMLYIVRT-----ASGPVTVHCSAGIGRTGTFVAIEACLqiltdgKELDLLGTCRALRNSRAGSIQVDIQY
  . |.   ...  .||| .|| ..  ||..| ....      .||| ||||||.|||||.||.  .|      . |.|. . . .|. | |..| . ||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

MALV
. | 
rfly

0049260 (Phosphotyrosine protein) phosphatases II 189-371 4.9e-31 102.9 In-house 9-143 (152) alignment
Range on Protein: 189-371
Range on HMM: 9-143/152.0
APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYpekageamtfgawtilcsleddkdaniikrtlsvrnvdngkehilkHLHTKSW
 .|| ||| .  |. |||||. . .  .||||.| .|.|| ||.||.                                              . .   |
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................qylhlpw

PDRCVPNSTMALLRMLYIV----RTASGPVTVHCSAGIGRTGTFVAIEACLqiltdgKELDLLGTCRALRNSRAGSIQVDIQYMALV
|| .||.... || .| ..    .  .||| ||||||.|||||.||.  .|      . ..|. . . .|. | |...   |.. | 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 200-372 2.4e-29 96.8 In-house 102-282 (302) alignment
Range on Protein: 200-372
Range on HMM: 102-282/302.0
ATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTIL-CSLEDDKDANIIKRTLSVRNVDNG-------KEHILKHLHTKSWPDR
 |.  .| .. . ..| .| ||...||.. |||.|| .| |. ..|| .|.   |...| .    |... . .|.         ... .. |.  .||| 
stlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdh

CVPNSTMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
  |. . . | .|    .    | ||||||.|||||.|||   .|. .  |  |||     .|. | |..| . | . |. 
GapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 148-370 3.9e-29 96.2 In-house 42-228 (392) alignment
Range on Protein: 148-370
Range on HMM: 42-228/392.0
FDANPTKNRYKDVVCNDITRVIL---SDGGDGDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGkakcaqyypekagea
 . |  |||||...  | .||.|    |  | ||. | |......   .| .||  ||.. |||||| . ... |.|. .. |                 
keinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...............

mtfgawtilcsleddkdaniikrtlsvrnvdNG-KEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTASGPVT----VHCSAGIGRTGTFVAIEACLQI
                               .| . .     |   |||. ||. | .||...  |..  |  |    .|||||.||||  ..|.. .  
...............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvah

LTDGKELDLLGTCRALRNSRAGSIQVDIQYMAL
    . .|..     .|. |   .|.. ||  .
akktrmvdvfnfvtnirrkrpymvqtkeqyafi

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 200-368 9.4e-29 95.2 In-house 39-211 (255) alignment
Range on Protein: 200-368
Range on HMM: 39-211/255.0
ATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLeddKDANIIKRTLSVRNV-D-NGKEHILKHLHTKSWPDRCVPNST
 ||  |....| |||  .||||.  |.|. || .|.| .  | . .   .. ..      |... ||| .        | | .|| . | |...  |. .
ltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

MALLRMLYIVRTAsGPVTVHCSAGIGRTGTFVAIEACLQ------ILTDGKELDLLGTCRALRNSRAGSIQVDIQYM
  .| .| .|| .  .| ||||.||||. .|| .|   |        |.  ||| |   . ||..|...|.  .|  
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqla

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 146-378 3.9e-28 93.2 In-house 28-259 (267) alignment
Range on Protein: 146-378
Range on HMM: 28-259/267.0
KIFDANPTKNRYKDVVCNDITRVILSDGGDgDYIHANYVNGLN--APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDgkaKCAQYYPEKAGEAM
 |   |  .||. |..  | |||||..  . .|| | ||.| .    ||.||..   |. ||. .. . | . ||.|  | .|   .  ...| | |.| 
siaeknqernrlddnlpyddtrvilrtkee.eyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftd...nirlfwPPkmgqak

TFGAWTILCSLEDD-KDANIIKRTLSVRNvdnGKEHILKHLHTKSWPDRCVPNSTM-ALLRMLY--IVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT
 .   |.  ||| . .| .||   | ..|      | .   . | |      .  .  |. .|    .  .. |. |.||.|.||.|||. |.. |. . 
kyqdltvehslekeendyqiitlelkfkn...esahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerak

DGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYG
    .|.    | .|. | | ...  .|. . ..| .| 
tegvsdifdflrkirsqriglvdtkeryiyihellaeya

0051082 (Phosphotyrosine protein) phosphatases II 177-371 9.7e-27 88.8 In-house 4-146 (151) alignment
Range on Protein: 177-371
Range on HMM: 4-146/151.0
DYIHANYVNGLnapFILTQGATAatviDFWRMVVHTKTAYIVMLCEVMEDGkaKCAQYYPEKAgeamtfgawtilcsleddkdaniikrtlsvrnvdngk
|||...|| |    .....| .|    ||.... . .  .||.|.. .| |  .|..|.||                                       
dyinfsyvtgg...lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.....................................

eHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA-SGPVTVHCSAGIGRTGTFVAIEACLQIltdgkeLDLLGTCRALRNSRAGSIQVDIQYMALV
 . ..|..  .|||  .| |. |.|..| ...   .||| ||||||.|||||.||.  .|.       ..|  . . .| .| |..|   |.. . 
.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

subfamily_ptpA1_pd Subfamily ptpA1 150-332 1.6e-26 88.0 In-house 46-250 (418) alignment
Range on Protein: 150-332
Range on HMM: 46-250/418.0
ANPTKNRYKDVVCNDITRVILS---DGGDGDYIHANYVNGLN-APFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGE-A--
 | .|||| ...  . ||| |    |    ||| |||..|     || |||    |. ||||||   .   ||||    |. . || .|.||. |     
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

------MTFGAWTI-LCSLEDDKDANIIKRTlsVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRT----------ASGPVTVHCSAGIGRT
        ||.... |  . .| . .|| |   .|   .|. . . . . . |||. .|. |  . ..|. .               |. ||||||.|||
iygngnevfgtysvelveviqdpereiitrn..irltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrt

GTFVAIE
|||..  
gtfctav

subfamily_hpo-7_pd Subfamily hpo-7 201-368 2.1e-26 87.4 In-house 46-217 (263) alignment
Range on Protein: 201-368
Range on HMM: 46-217/263.0
TVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDDkdaNIIKRTLSVRN-VD-NGKEHILKHLHTKSWPDRCVPNSTM
|.  |....| |||  .||||.  |.|. || .|.| .  | . .   .. ..   .   .....|| . . ..   | | .||   | |...  |. . 
tidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpelar

ALLRMLYIVRTAsGPVTVHCSAGIGRTGTFVAIEACLQ------ILTDGKELDLLGTCRALRNSRAGSIQVDIQYM
  |..| ..|    .. ||||.||||.  |. .|   |        |.  ||| |   . ||.||...|.  .|  
eilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLa

PTPc_DSPc_SM00012 280-375 3.1e-26 87.0 In-house 2-104 (105) alignment
Range on Protein: 280-375
Range on HMM: 2-104/105.0
LKHLHTKSWPDRCVPNSTMALLRMLYIVRTASG------PVTVHCSAGIGRTGTFVAIEACLQILTDG-KELDLLGTCRALRNSRAGSIQVDIQYMALVQ
.||.| ..||| .||... ..|..|  |..         || ||||||.||||||||.. .|| |... ||.|.. ....||..|.|..| . ||. | .
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ILI
.|.
all

0044763 (Phosphotyrosine protein) phosphatases II 173-376 9.7e-26 85.9 In-house 15-169 (178) alignment
Range on Protein: 173-376
Range on HMM: 15-169/178.0
GGDGDYIHANYVNGLnapFILTQGATaatvIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGeamtfgawtilcsleddkdaniikrtlsvrnv
   .|||.|... .    ..|..  .     |.....   .  .||.|.| .| |. || .|.||.||                                
lersdyinaseilpg...lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................................

dngkehiLKHLHTkSWPDRCVPNSTMALLRMLYIVR----TASGPVTVHCSAGIGRTGTFVAIEACLQIltdgkELDLLGTCRALRNSRAgSIQVDIQYM
       ...||.  .|| .||...  .|... ...    .  ||| ||||||.||.||.||.  ...       |.|    . .|. |   .. . |. 
.......iqylhi.pipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnpgqlr

ALVQILIN
 | ..   
qLyefelr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 153-303 1.8e-25 84.4 In-house 35-189 (297) alignment
Range on Protein: 153-303
Range on HMM: 35-189/297.0
TKNRYKDVVCNDITRVILSDGG-DGDYIHANYVNGLNAP----FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGA
 ||||.|..  | ||| |  .  . ||| |.||   . .    .||.|| . ||| |||..|..     |||.... |||. ||| |.|.  .| .. | 
rknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagd

WTI--LCSLEDDKDANIIkRTLSVRNVdnGKEHILKHLHTKSWPDRCVPNSTMALLRM
  .  | |  |. |  |.   | .      ..  ..|    ||||  ||.    | |.
vvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrf

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 110-383 1.6e-23 77.8 In-house 7-284 (303) alignment
Range on Protein: 110-383
Range on HMM: 7-284/303.0
KVFFKFASDAVKKNpPEYSVEFMTKVKPYPGQPMERKIFDANPTKNRYKDVVCNDITRVILSDggdGDYIHANYVNgLN--APFILTQGATAATVIDFWR
. .   | . ....  . .|. . ||  |    . .. |  |  |||. ||.| | ..| |||     ||||.|.. |.     ||||   . |  |||.
qkwkllakrtlded.aniavnefekvvsylppsvsknqfvknmdknrfvdvicldhskvklsd...ssyihasyle.ldsskkailtqlplshtaadfwq

MVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKaGEAMTFGAWTILcsLEDDKDANIIK-RTLSVRNVDNGKEHILKHLH-TKSWPDRCVPNS-TMALLRML
|... |   ...|    |  |      .|..  . . |   .|   . . |  .. .  .| |  | ||. . . |.|  |.||   .|.  .  ... .
miieqkvkcvlllltdseydklggdsvfprn.qdflkfeersir..vgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqi

YI----VR--TASGPVTVHCSAGIGRTGTFVAIEA-CLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDNGY
.     .|  . | |      .| ||.|||  .|.  | . ..   |||.     .|| |  ..|   |.  .  .| ..  |||.
wqlqsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 146-381 3.2e-21 70.0 In-house 46-288 (302) alignment
Range on Protein: 146-381
Range on HMM: 46-288/302.0
KIFDANPTKNRYKDVVCNDITRVILSDGgDGDYIHANYVN--GLNAPFILTQGATAATV---IDFWRMVVHTKTAYIVMLCEVMEDGKaKCAQYYPEKAG
|.| .|. ||. .|| . | ..|.|.     .|..|  |.   |. . ||.| ..  ..    .||||| . | . .|.|    |  |    ...|.|.|
kafkknlkknqsedvpildsnlvkleae.pdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksg

EAMTFGAWTILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIV----RTASGPVTVHCSAGIGRTGTFVAIEACLQ
.  ..|.  .     . ....  . .. |   .     . .  ... |..  || .  .| .    |      |. .. .    |.|| |.|..  . ..
dykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

ILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGKDN
 |..|||     . ...|. |. ...  .||. |  .|. |.| .
klqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

subfamily_CG42327_pd Subfamily CG42327 153-309 6.4e-21 69.3 In-house 30-192 (319) alignment
Range on Protein: 153-309
Range on HMM: 30-192/319.0
TKNRYKDVVCNDITRVILSDGGDGD---YIHANYVNGLNA---PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMT--
 |.|. .||    |||.|   || |   |..|.|| | .     .| .| .   .  ||||.|   ..  || |... | |  .||.|.| |..   |  
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

FGAWTILCSLEDDKDANIIkRTLSVRNVDNGKEHILKHLHTkSWPDRCVPNSTMALLRMLYIVRT
.| . .     . ||  .|  || ...||. .   | |     |..  || .  ||. ||  ||.
yGdilvtlkgrevkdryai.stlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs

0048076 (Phosphotyrosine protein) phosphatases II 233-374 7.7e-21 69.7 In-house 1-139 (145) alignment
Range on Protein: 233-374
Range on HMM: 1-139/145.0
QYYPEKAGEAMTFGAWTILCSLEDDKDANiIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVPNSTMALLRMLYIVRTA---SGPVTVHCSAGIGRTGTFV
.|.| .  . . .| ..  ..||  || . |.. |.. .  .. |.   ...  .|||..||...  ||..| ....|    ||| ||||||.|||||.|
pywpseilpglylgslptaldlellkdlg.ittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

AIEACLQiltdgKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
|.  .|.     . ..|  . . .|. | |... . |.  | . .
aaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefe

0048179 (Phosphotyrosine protein) phosphatases II 241-372 3.9e-19 64.3 In-house 9-139 (144) alignment
Range on Protein: 241-372
Range on HMM: 9-139/144.0
EAMTFGAWTILCSLEDDKDANIiKRTLSVRNVDNGKEHILK--HLHTKSWPDRCVPNSTMALLRMLYIVRTA---SGPVTVHCSAGIGRTGTFVAIEACL
. . .| .  ...||  |. .| .  .....     . .    ...  .|||..||...  ||..| ....|   .||| ||||||.|||||.||.  ..
pglylgslptaldlellkklgi.ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk

qiltD-GkeLDLLGTCRALRNSRAGSIQVDIQYMALVQ
      |  |.|  . . .|. | |... . |.. | .
....klg..lsleealalvrsrrpgavpnpgqlrfLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 277-399 1.2e-14 48.5 In-house 88-216 (440) alignment
Range on Protein: 277-399
Range on HMM: 88-216/440.0
EHILKHLHTKSWPDRCVPNSTMALLRMLYIVR-----TASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALV
 . ||. | ..|||. ||. .  .|.|.  |      ...||. |||||| ||||  .|... |.      ..|..    ..||.|   .|.  ||  . 
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QILIN-YGKDNGYWDDSDLDDRVELLTWN
. ...     .    . |. .||| . | 
eavlegllcgdtliledditerveqiqwp

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 191-368 1.8e-14 48.4 In-house 6-193 (198) alignment
Range on Protein: 191-368
Range on HMM: 6-193/198.0
FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDD-KDANIIKRTLSVRNVDNGKEHILKHLHTKSWP
.| || .   |. |||.||  | . .|||. .   . .|  . |.|     .  .|. .. .       |  |    |.           . |    || 
yiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DRCVPNSTMALlRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKE--LDLLGTCRALRNSRAGSIQVDIQYM
..  || .. .  ..   |            || |||| | | || |||..  ..   . |   .||.  .. ||..| | |    .| 
ekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 191-368 2e-14 48.3 In-house 7-194 (199) alignment
Range on Protein: 191-368
Range on HMM: 7-194/199.0
FILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEDD-KDANIIKRTLSVRNVDNGKEHILKHLHTKSWP
.| || .   |. |||.||  | . .|||. .   . .|  . |.|     .  .|. .. .       |  |    |.           . |    || 
yiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftswk

DRCVPNSTMALlRMLYIVRT--------ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKE--LDLLGTCRALRNSRAGSIQVDIQYM
..  || .. .  ..   |            || |||| | | || |||..  ..   . |   .||.  .. ||..| | |    .| 
ekttpnvalfv.gfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 153-239 3.9e-13 43.8 In-house 49-154 (350) alignment
Range on Protein: 153-239
Range on HMM: 49-154/350.0
TKNRYKDVVCNDITRVILSD-----------GGDGDYIHANYVNG------LNAPF--ILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQ
.|||||...  . .||.|                 ||| |||..        |. |  | ||. .  || ||...... |   |..| . .| .  || .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YYPEKA
|..| .
YWqegs

subfamily_eak_pd Subfamily eak 187-295 4.7e-12 39.9 In-house 91-196 (332) alignment
Range on Protein: 187-295
Range on HMM: 91-196/332.0
LNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWTILCSLEdDKDANIIKRTLSVRNVDngKEHILKHLHTK
.   .|||  |    |  ||.||.  |.  ||.| | .| .  |  .|.|.|. | . || . . .     | ...  | | ..  .  . | ..| .  
vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef.vkrniletrllelskGn..ethrvlhykvf

SWPDRCVPN
 | .  .| 
Gwtettlpk

subfamily_CG42327_pd Subfamily CG42327 308-379 6.2e-12 39.8 In-house 244-316 (319) alignment
Range on Protein: 308-379
Range on HMM: 244-316/319.0
RTASGPVTVHCSAGIGRTGTFVAIEACLQILTDG-KELDLLGTCRALRNSRAGSIQVDIQYMALVQILINYGK
|   ||..|||| |.||||. .| .  .. | .  . .|.  .   .|. || ...   ||  . ..| .| |
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 149-295 6.8e-11 36.2 In-house 94-238 (244) alignment
Range on Protein: 149-295
Range on HMM: 94-238/244.0
DANPTKNRYKDVVCNDITRVILSDGGDGD-YIHANYVNGL--NAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGkakcaQYYPEKagEAMTF
  |  |||    .  |. || || |  |. || | .|  |   | .||||   | | .|||.|..  .   .|.|  | |.      .|.|.   | . .
pnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds..eplew

GAWTILCSLEDDKD-ANIIKRTLSVRNVDNGKEHILKHLHTKSWP-DRCVPN
    |  .| |  .  ||    | .    |     |  .    || |   ||
yeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgttpn

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 145-226 3.3e-09 30.7 In-house 31-122 (347) alignment
Range on Protein: 145-226
Range on HMM: 31-122/347.0
RKIFDANPTKNRYKDVVCNDITRVILSDG----GD----GDYIHANYVNGLNA--PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMED
 . .. . .||| |||  .| |||.||      .       || | ...  ||   .||||     || |||.||  || . .| . | ..|
svewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 280-336 7.2e-09 29.8 In-house 217-287 (350) alignment
Range on Protein: 280-336
Range on HMM: 217-287/350.0
LKHLHTKSWPDR---CVPNSTMALLR-----------MLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQ
. .|. | |.|      |.| .  |             ...    | |. ||||||.|||||.|...  |.
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDslls

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 313-372 6.2e-08 26.8 In-house 230-289 (297) alignment
Range on Protein: 313-372
Range on HMM: 230-289/297.0
PVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQ
.. ||||||.||.|  |  .. |..|  ..  |     . ||. ||  .|   |.  | .
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 302-339 7.4e-08 26.1 In-house 256-293 (349) alignment
Range on Protein: 302-339
Range on HMM: 256-293/349.0
RMLYIVRTASGPVTVHCSAGIGRTGTFVAIEACLQILT
  ||.    . .. |||||| ||||..| ..  |.||.
arlyldtdqlstllvhcsaGcGrtGvlvtldlllsile

subfamily_CDC14_pd Subfamily CDC14 290-331 1.3e-07 25.7 In-house 243-283 (328) alignment
Range on Protein: 290-331
Range on HMM: 243-283/328.0
DRCVPNStMALLRMLYIVRTASGPVTVHCSAGIGRTGTFVAI
|  .|.. . . ..| |. .|.| ..||| ||.|||||..| 
DGstPsd.aivkkfleiaekaeGaiavhCkaGLGrtGtLiac

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 315-375 1.6e-07 25.6 In-house 2-62 (69) alignment
Range on Protein: 315-375
Range on HMM: 2-62/69.0
TVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILI
 ||||.| ||||||.||   .  .   | .|..   . .|  |   .  .|.|. .   |.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalv

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 190-252 3.2e-07 24.0 In-house 237-295 (440) alignment
Range on Protein: 190-252
Range on HMM: 237-295/440.0
PFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEdgkAKCAQYYPEKAgEAMTFGAWTILC
 || ||    .||.||||.|   . . |.|| .. .     |. |.| ..  ..||| .|.  
afiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvnt.rsvtfgpftvgh

subfamily_PTPDC1_pd Subfamily PTPDC1 286-369 4.7e-07 24.4 In-house 88-167 (182) alignment
Range on Protein: 286-369
Range on HMM: 88-167/182.0
KSWPDRCVPnSTMALLRMLYIVRTA--SGPVTVHCSAGIGRTGTFVAieaCLQILTdgKELDLLGTCRALRNSRAGSIQVDIQYMA
 .|.|  |. |   .| .  .|  |   | |.||| || ||||  .|   |  . .  |.|.   . . .|. |. |||   |   
fgwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvlia...cylvya..krltaekaiklvrskrpksiqtreqvel

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 316-374 5.6e-07 23.8 In-house 2-60 (69) alignment
Range on Protein: 316-374
Range on HMM: 2-60/69.0
VHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQIL
||||.| ||||||.||   .  .   | .|..   . .|  |   .  . .|| . . |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal

0038934 (Phosphotyrosine protein) phosphatases II 287-330 6.5e-07 24.7 In-house 86-134 (194) alignment
Range on Protein: 287-330
Range on HMM: 86-134/194.0
SWPDRCVPNSTMALLRMLYIV-----RTASGPVTVHCSAGIGRTGTFVA
 .||.... |.  ||| | .|     . ..| | ||| ||.|||||.||
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 139-187 1.3e-06 22.5 In-house 36-84 (95) alignment
Range on Protein: 139-187
Range on HMM: 36-84/95.0
PGQPMERKIFDANPTKNRYKDVVCNDITRVILSDGGDGDYIHANYVNGL
 | |      .||  |||. ...  | |||.|.   | ||| | .|.| 
sgapytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 169-289 1.4e-06 22.7 In-house 11-122 (130) alignment
Range on Protein: 169-289
Range on HMM: 11-122/130.0
IlsdggDGDYIHANYVN--GLNAPFILTQGATAATVIDFWRMVVHTKTAYIVMLCEVMEDGkakcaQYYPEKagEAMTFGAWTILCSLEDDKDANIIKR-
      . .||.|..|   |  | ..||| . |.| .|||.|...     .|.|  | |.      .|.|.   | . .    |. .| | .. . ||  
q.....gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpds..ePlewyeediivtltdrdefknikas

TLSVRNVDNGKEHILKHLHTKSWP
 | . .  |   . |  ..   ||
nleiesdlneshqaltmfqisnwp

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 119-231 3e-06 20.9 In-house 5-118 (332) alignment
Range on Protein: 119-231
Range on HMM: 5-118/332.0
AVKKNPPEYSVEFMTKVKPYPGQpmeRKIFDANPTKNRYKDVVCNDITRVILS-DGGDGDYIHANYVNGLN--APFILTQGAT-AATVIDFWRMVVHTKT
||  . ||   .. |    ||        |  |   ||   . | | .|| |. . |  |.  |..|.| .  . .|..|      |   |||||   | 
avtvegpellnqmhtsamtypnt...ydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkp

AYIVMLCEVMEDGKAKC
. |... .. |  | |.
smilvfgdidekqkrka

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 195-377 3.2e-06 20.0 In-house 124-308 (346) alignment
Range on Protein: 195-377
Range on HMM: 124-308/346.0
QGATAATVIDFWRMVVHTKTAyIVMLCEVMEDGKAKCAQYYPEKAGEAMTFGAWtILCSLEDDKDANIIKRTLSVRNVDNGKEHILKHLHTKSWPDRCVP
|    . | ||| |. . .   .| |    .  |   .  . .. |     |   ..     |   .  . |. |    |    | .  |   |     |
qmenesfvedfwymiyqeqih.lvylmvpddklkntttslfndenggyqytgkm.finnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqp

NSTMALLRMLYIVRT----ASGPVTVHCSAGIGRTGTFVAIEACLQILTDGKELDLLGTCRALRNSRAGSIQVDIQYMALVQILINY
  |. ...|..   .     .  | |    | ||. .|.     .. | .| | ...   ..... | |...   || ..  |...|
pktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdy

PTPc_motif_SM00404 300-332 9.7e-06 20.5 In-house 69-101 (140) alignment
Range on Protein: 300-332
Range on HMM: 69-101/140.0
LLRMLYIVRTASGPVTVHCSAGIGRTGTFVAIE
.|...  ...  | | ||| ||. |..|... .
vldfienaekkggkvlVHCqaGvSRSatliiaY