Gene T23G7.5 in Caenorhabditis elegans

Synonym: CELE_T23G7.5, pir-1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP11
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP187_AA protein Get Run
CeleP187_AA_33-206 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP11_pd Subfamily DSP11 25-205 2e-86 282.4 In-house 1-178 (178) alignment 
Range on Protein: 25-205
Range on HMM: 1-178/178.0
LPDRWNIYDNVGRDIDGTRFVPFKTPLDSSFfdGKNMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVnEREDL
.||||. |..||..|.||||..|||||..||  .|....| .|..|.|.. .|..||..|||||||||||||||.|..|.|||||||||||||| ..|.|
vPdrwkkykpvgdkiegtrfiafktPlkesf..dkkveeekrftpkdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhev.pkeel

VQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERKKK
|..|..|||||........||||||||||.||||||||||.|||..|...|||..||..|||..|||.|.|.|...|..||
vkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdLkklekdkk
0038934 (Phosphotyrosine protein) phosphatases II 25-201 2.3e-49 163.0 In-house 2-173 (194) alignment 
Range on Protein: 25-201
Range on HMM: 2-173/194.0
LPDRWNIYDNVGRDIDGtRFVPFKTPLDSSFFDGknMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDL
|||||  |..||. | | ||..||.||..|...   .. ...|....|... .. |...|||||||||.||| ..|. ..|..|||| .|.. .    ..
lPdrwlkyervgdiitg.rfiafkvPlsgsldky..ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPslei

VQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAE
...|...|.||.  .|. |....|||..||.|||.|...|.| . ..|| .|| .|.  |.. ... .| . |..  
llrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkry
subfamily_RNGTT_pd Subfamily RNGTT 26-199 5e-47 154.0 In-house 1-169 (189) alignment 
Range on Protein: 26-199
Range on HMM: 1-169/189.0
PDRWNIYDNVGRDIDGtRFVPFKTPLDSSFFdgKNMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLV
|.||      |. |.. .|.|||||| ...   .... | .|  . |.|  .  ....|||||||||.|||.| |  ..|.|| ||.| |. .   .. |
PerWlnCPrkgkliae.kflpfktplskryd..ddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqv

QDFINAVKEFVNdkENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYE
. ||. |.||..  .|  ..|||||||| ||||.||. |.... ..|...|...|   |   . .|.| | |..
kefiklveeffk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellr
DSPc Dual specificity phosphatase, catalytic domain 66-203 1.5e-31 104.0 Pfam-A 2-133 (133) alignment 
Range on Protein: 66-203
Range on HMM: 2-133/133.0
QFGVKTLISLAQQANKQIGLVIDLTNTDRYYkkteWADHGVKYLKLNCPGHEvnEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYM
..| |. .|||......| |||..|.. .      .|..  .. .|..| ..  |.|. .........||... |..|| . |||..|..|...||..|.
ylgskstaslalleklgitlvinvtkevpnn....naikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

IDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
.. .|.|...|.......|.. .........|.|.|||
mktknlslneAyefvkerrskispnagflrqLleyerk
DSPc Dual specificity phosphatase, catalytic domain 66-203 1.5e-31 104.0 In-house 2-133 (133) alignment 
Range on Protein: 66-203
Range on HMM: 2-133/133.0
QFGVKTLISLAQQANKQIGLVIDLTNTDRYYkkteWADHGVKYLKLNCPGHEvnEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYM
..| |. .|||......| |||..|.. .      .|..  .. .|..| ..  |.|. .........||... |..|| . |||..|..|...||..|.
ylgskstaslalleklgitlvinvtkevpnn....naikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl

IDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
.. .|.|...|.......|.. .........|.|.|||
mktknlslneAyefvkerrskispnagflrqLleyerk
0036282 (Phosphotyrosine protein) phosphatases II 38-202 1.5e-29 98.3 In-house 13-167 (174) alignment 
Range on Protein: 38-202
Range on HMM: 13-167/174.0
DIDGTRFVPFKTPLDssffdgkNMPVELQFGVKTLISLAQQANKQIGLVIDLTNTDRYYkkteWADHGVKYLKLNCPGHEVNEREDlVQDFINAVKEFVN
 .  .|.. .. ||.       ...   ..|..|...| .   ......|......|..    . ..|..||.|..|.|.| . .  ...|...|.|...
syitprliagqgpla.......fwemlkelgittvvmlleekelglykcinywpelred....lerlgiqylylpwpDhgvpdlsi.llefvkfveeals

DkeNDGKLIGVHCTHGLNRTGYLICRYMIDVDNY-SASDAISMFEYYR---GHPMEREHYKKSLYEAER
.  ..|. . |||..|..|||.|.. |.. .  . |. ||....   |   ..  ..... . ||. |.
e..dpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
PTPc_motif_SM00404 59-203 1.3e-27 91.4 In-house 3-140 (140) alignment 
Range on Protein: 59-203
Range on HMM: 3-140/140.0
KNMPVELQFGVKTLIS-LAQQANKQIGLVIDLTNTDRYYkktewaDHGVKYLKLNCPgH-EvnEREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNR
...  .|..| |. .. .|......| .||..|.. .        ..  ..  |..| . .  ...| .......|..|... |..|. . |||..|..|
srilphlylgskskaqnpallkklgithvinvteevslt......kensgfqilqip.ldd..nekdklskyldkvldfienaekkggkvlVHCqaGvSR

TGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
...||. |... ...|...|.......| . .........|.| |.|
SatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
0044763 (Phosphotyrosine protein) phosphatases II 79-204 2.2e-24 81.5 In-house 45-170 (178) alignment 
Range on Protein: 79-204
Range on HMM: 45-170/178.0
ANKQIGLVIDLTNTDRYY----KKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSAS
 .  |.....||......     .  . ..|..||....|.| | .  . ...|.....|...   ..|. . |||..|..|.|.|.. |.. . ..|. 
kelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkklglsle

DAISMFEYYRGhPMEREHYKKSLYEAERKK
.||...  .|   ...... . ||| |.. 
eaielvrerRp.ivpnpgqlrqLyefelrl
0041856 (Phosphotyrosine protein) phosphatases II 42-206 7.3e-24 79.8 In-house 34-172 (182) alignment 
Range on Protein: 42-206
Range on HMM: 34-172/182.0
TRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAqqankqiglvidltntDRYYKKTEWADHGVKYLKLNCPGHEVNErEDLVQDFINAVKEfvndken
|||. ...||.|.. |  .|  ||  |..|...|.                ...|  ... ..|..||.|..|.|.| .  | . |||..|.|       
trfiatqgpllstvadflrmlkel..gittivnlt................eelywpellerlgiqylylpwpDhgvpd.ldelldfieevle.......

DGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERKKKY
.|. . |||..|..|||.|.. |.. . ..|. .|....  .| .  .....   |. |.. ...
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0040438 (Phosphotyrosine protein) phosphatases II 40-203 1.5e-23 79.0 In-house 70-274 (317) alignment 
Range on Protein: 40-203
Range on HMM: 70-274/317.0
D--------------GTRFVPFKTPLDSSFFDGKNMPVELqfgvktlislaqqankQIGLVIDLTNTDRYY-----------------------KKTEWa
|              ...|. ...||.....|  .|  |.                ...... ||... .                        ...|. 
dsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweq................gvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.

DHGVKYLKLNC-------------------PGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAIS
..|.....| .                   | | | .  ||..||..||.|. .   ..|. . |||..|..|||..|. |..        .... .|. 
lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavk

MFEYYRGHPMEREHYKKSLYEAERK
..  .|.. .. . . . ||.|...
elreqRpgavqtpeqyrflydalle
0048076 (Phosphotyrosine protein) phosphatases II 71-202 8.2e-23 76.1 In-house 18-140 (145) alignment 
Range on Protein: 71-202
Range on HMM: 18-140/145.0
TLISLAQQANKQIGLVIDLTNTDRYYKktewaDHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNDkendGKLIGVHCTHGLNRTGYLICRYMIDVDN
| ..|.. .. .|..|..||.. ....     ..|..|| |..|.|.| .  .|...|.....|....    |. . |||..|..|||.|.. |..   .
taldlellkdlgittvlnltselelle.....rlgiqylylpwpDhgvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmlllg

YSASDAISMFEYYRGHPMEREHYKKSLYEAER
.|. .|. ..  .| .  ..... . |||.|.
vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 71-202 2.1e-22 74.9 In-house 18-142 (144) alignment 
Range on Protein: 71-202
Range on HMM: 18-142/144.0
TLISLAQQANKQIGLVIDLTNTdryYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkenDGKLIGVHCTHGLNRTGYLICRYMIDVDN
|...|.. .. .|..||.||..   | .... ..|..||.|..|.|.| .  .|...|.....|...    .|. . |||..|..|||.|.. |.. . .
taldlellkklgittvinltee...yepefleregiqylhlpwpDhgvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmkklg

YSASDAISMFEYYRGHPMEREHYKKSLYEAER
.|. .|. ..  .| .  . ... . |.| |.
lsleealalvrsrrpgavpnpgqlrfLleyek
0043147 (Phosphotyrosine protein) phosphatases II 79-204 3.3e-22 74.5 In-house 41-160 (172) alignment 
Range on Protein: 79-204
Range on HMM: 41-160/172.0
ANKQIGLVIDLTntDRYYKKTEWADHGVKYLKLNCPGHEVNeREDLVQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDvDNYSASDAIS
 ...|.....||  ...| ..   ..|..|| |..| | |    .|...|.. ..|..   ...|. . |||..|..|||.|.. |..   ..|. .|..
kelgithivnlt..ellydpellerlgiqylylpwpDhgvp.llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeava

MFEYYRGHPMEREHYKKSLYEAERKK
..   |..  . ... . ||. |.. 
lvrekRpgavqnpsqyrflyyfekll
0040439 (Phosphotyrosine protein) phosphatases II 40-202 6.1e-22 73.9 In-house 52-243 (249) alignment 
Range on Protein: 40-202
Range on HMM: 52-243/249.0
DGTRFVPFKTPLDSSFFDGKNMPVElqfgvktlislaqqanKQIGLVIDLTNTDRY-------------------------------------------Y
 ..||. ...||.... |  .|  |                 .|. ...||.....                                           |
ikrrfiatqgPlpetvedfwrmlwe................lgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnly

KKTEWADHGVKYlkLNCPGHEVNEREDLVQDFINAVKEFVNDKeNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMERE
....   ... |  ...| | | .  . . |||.||......  ..|. . |||..|..|||..|. |..        .... .|....  .|..  . .
dgesrtvlhiqy..tdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

HYKKSLYEAER
.. . ||||..
eqyrflyeall
0043336 (Phosphotyrosine protein) phosphatases II 36-201 1.1e-21 73.0 In-house 68-273 (278) alignment 
Range on Protein: 36-201
Range on HMM: 68-273/278.0
GRDID--------------GTRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAQQAN-----------------------------KQIGLVIDLTNT
| | |              ...|. ...||.... |  .|  ||  ||.|...| .                                ..   |..|. |
ggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwel..gvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevt

DRYYKKTewaDHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHP
.......    ... |  |. | |.| |  .|..||..||.|...   .... . |||..|..|||..|. |..     .  .... .|....  .|.. 
nlgdges...rtvthyhylgwpdhgvpeslsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpga

MEREHYKKSLYEAE
.. . . . ||||.
vqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 80-202 1.7e-21 72.2 In-house 74-240 (245) alignment 
Range on Protein: 80-202
Range on HMM: 74-240/245.0
NKQIGLVIDLTNTDRYYK-----------------------------------------KTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVND
. .|  ...||... . .                                         .. .  ... |. |..|.| | .  .|..||...|......
elgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae

keNDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAER
  .... . |||..|..|||..|. |..        ..|. .|. ..  .|..  . ... . ||||..
..dsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 79-202 1.8e-21 72.2 In-house 69-239 (243) alignment 
Range on Protein: 79-202
Range on HMM: 69-239/243.0
ANKQIGLVIDLTNTD----------------------------------------RYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVND
 . .|. ...||...                                        .... ...  ....|. |. |.| | .  . ..||...|.||...
welgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefiee

-----KENDGKLIGVHCTHGLNRTGYLICRYMIDVD-NYSASDAISMFEYYRGH-PMEREHYKKSLYEAER
     ....|. . |||..|..|||.||. |..    .... .|. ..   |..   . ... . ||||..
llsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 3-203 3.4e-21 71.7 In-house 55-302 (307) alignment 
Range on Protein: 3-203
Range on HMM: 55-302/307.0
NYHHNHNYQHRPRGYERLPGKRLPD-------------RWNIYDNVGRDIDGTRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAQQANK--------
| . |      |  . |   . |..             |....  ..  . ...|. ...||.... |  .|  |.  ||.....| .   .        
nkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweq..gvtvivmltelvelgrekcaqy

--------QIGLvidltNTDRYYKKTEWADHGVKYLKLNC------------------PGHEVNEREDLVQDFINAVKEFVNDKeNDGKLIGVHCTHGLN
        ..|       | ..........  | .|.. .                  |.| | .  . . |||..|......  ..|. . |||..|..
wPdegeeltygn.....ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleel.pkggpvlVHCsaGvg

RTGYLICRYMIDVDN--------YSASDAISMFEYYRGHPMEREHYKKSLYEAERK
|||..|. |.. .          ... .|....   |..  . ... . ||||...
RtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0049772 (Phosphotyrosine protein) phosphatases II 57-206 8.2e-21 70.5 In-house 167-275 (314) alignment 
Range on Protein: 57-206
Range on HMM: 167-275/314.0
DgknmpvelqfgvktlislaqqankqiglvidltntDRYYKKTEWADHGVKYLKLNCPGHEVNeREDLVQDFINAVKEFvndkeNDGKLIGVHCTHGLNR
                                    ...| .  . ..|.||| ...|.....  .. ...|.....|.     ..|. . |||..| .|
k...................................eelydpelferlgikylripvpDgsap.lledfdeflefieea.....dkggpvlvHCkaGkgR

TG-YLICRYMIDVDNYSASDAISMFEYYRGhPMEREHYKKSLYEAERKKKY
|| .... |..   ..|. .|....   |     .... ..| . | . ..
tgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilea
0049260 (Phosphotyrosine protein) phosphatases II 77-202 8.3e-21 69.7 In-house 26-147 (152) alignment 
Range on Protein: 77-202
Range on HMM: 26-147/152.0
QQANKQIGLVIDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFvndKENDGKLIGVHCTHGLNRTGYLICRYMIDvDNYSASDA
 .  |. |  . .. |...... .. ... .|| |..| | | . ..|..... .....   ....|. . |||..|..||| |.. |..   ..|. .|
wrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleea

ISMFEYYRGHPMEREHYKKSLYEAER
....   | .  . ... . ||| |.
valvrekRpgavpnpgqlrflyefek
0039614 (Phosphotyrosine protein) phosphatases II 81-203 4.4e-19 64.5 In-house 124-287 (297) alignment 
Range on Protein: 81-203
Range on HMM: 124-287/297.0
KQIGLVIDLTNTDRY--------------------YKKTEWADHGVK-----------------YLKLNCPGHEVNEREDLVQDFINAVKEFVNDKeNDG
 ..  .. ||... .                    . ...  ..|..                 .. .. | | | .  .|...|...|.|...   ..|
qgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael.pkg

KLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKSLYEAERK
. . |||..|..|||..|. |..        .... .|....  .|..  . ... . ||.|...
gpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0046846 (Phosphotyrosine protein) phosphatases II 77-202 6e-19 63.9 In-house 42-170 (176) alignment 
Range on Protein: 77-202
Range on HMM: 42-170/176.0
QQANKQIGLVIDLTNTD-------RYYKKTeWADHGVKYLKLNCPGHEVNEReDLVQDFINAVKEFVNDKendgKLIGVHCTHGLNRTGYLICRYMIDV-
.  . .|..|..||.          .| .  . ..|..|| |. | | | .  .|.........|.....    . . ||| .|..||| |.. |..   
mlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlvaayllele

DNYSASDAISMFEYYRG-HPMEREHYKKSLYEAER
 ..|. .|....  .|  .  . ... . |||.|.
kglsveealalvreqRplgavqtpeQyrflyefel
0045098 (Phosphotyrosine protein) phosphatases II 41-203 1.9e-18 62.3 In-house 63-270 (278) alignment 
Range on Protein: 41-203
Range on HMM: 63-270/278.0
GTRFVPFKTPLDSSFFDGKNMPVELqfGVKTLISLAQ------------------------------QANKQIGLVIDLTNTDRYYKKTEWADHGVKYLK
...|. .  ||.| . |  .|  ||  |......|..                                . .   ...|. |. .......  .||..|.
pkkfIatqgPlpstvadfwrmlwel..gitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

L-NCPGHEVNERE--DLVQDFINAVKEFVN----------DKENDGKLIGVHCTHGLNRTGYLICRYMIDVD---NYSASDAISMFEYYRGH-PMEREHY
. . | |.| . .  . ...... ..|...            ...|. . ||| .|..||| |.. |..      .... .|....  .|..   . .. 
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

KKSLYEAERK
 . |||....
yrflyeflle
0051082 (Phosphotyrosine protein) phosphatases II 76-186 3.5e-18 61.1 In-house 27-134 (151) alignment 
Range on Protein: 76-186
Range on HMM: 27-134/151.0
AQQANKQIGLVIDLTNTD-RYYKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeNDGKLIGVHCTHGLNRTGYLICRYMIDvDNYSAS
.. .. .|  ...|.... |.| .  . ..|...| . .... .   ... . ........ .   .... . |||..|..||| |.. |..   ..|. 
ellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lgvsle

DAISMFEYYRGH
.|....  .|..
ealeeyrlkrpg
PTPc_DSPc_SM00012 94-201 5.2e-17 57.3 In-house 3-97 (105) alignment 
Range on Protein: 94-201
Range on HMM: 3-97/105.0
RYYKKTEWADHgvkylklN----CpghevnereDLVQDFINAVKEFVNDKENdGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPME
. |. |.| ||       .    .         | . ....|||.. |..|. .| . ||| .| .|||.... ...  .... .. ...|.. .   ..
khyhytgwpdh.......gvPees.........dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkq

REHYKKSLYEAE
|... .....  
Rpgmvqteeqyl
PTEN_1 75-188 5.5e-17 57.2 In-house 60-175 (196) alignment 
Range on Protein: 75-188
Range on HMM: 60-175/196.0
LAQQANKQIGLVIDLTNTDRY----YKKTEWADHGVKYLKLNCPGHEVNEReDLVQDFINAVKEFVNDKENdGKLIGVHCTHGLNRTGYLICRYMIDVDN
| ..  . | ||..|.. . .    | ..|. ..||.||..  . | .    . ..|... ..| .  ..| |. . |||..||.|.| ... |..   .
ldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsl.selfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvvaayLmykgk

YSASDAISMFEYYRGHPM
..| .|....   | . .
ltadeAlelvrekRppga
0048567 (Phosphotyrosine protein) phosphatases II 122-188 4.1e-15 50.5 In-house 53-122 (157) alignment 
Range on Protein: 122-188
Range on HMM: 53-122/157.0
EDLVQDFINAVKEFVNDKENDGKLIGVHCTHGL---NRTGYLICRYMIDVDNYSASDAISMFEYYRGHPM
 ... .||. ...| .. |. || | |||..||    ||..||. |.| . ......|| .. ..| . .
lailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsv
0051429 (Phosphotyrosine protein) phosphatases II 71-202 4.8e-14 48.2 In-house 34-222 (272) alignment 
Range on Protein: 71-202
Range on HMM: 34-222/272.0
TLISLAQQANKQIGLVIDLTNTDRYYKKT-EWADHGVKYLKLNCPGHEVNERE-----------------------------------------------
|  .... .. .|  ..||.... . .   ..  .|..|| |....... . .                                               
taadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

----DLVQDFINAVKEfvndkendGKLIGVHCTHGLNRTGYLICRYMIDvDNYS--------------ASDAISMFEYYRGHPMEREHYKKSLYEAER
    . . ...... .        |. . |||..| .||| ... ...   . |              . .|...   .| .  . |.  . ||||..
gvpqeallellellld........ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall
0046845 (Phosphotyrosine protein) phosphatases II 88-200 1.1e-13 46.6 In-house 152-269 (284) alignment 
Range on Protein: 88-200
Range on HMM: 152-269/284.0
DLTNTDRYYKKTEWADHGvkYLKLNCPGHEVNEREDLVQDFINAVKEFVNDkENDGKLIGVHCTHGLNRTGYLICRYMIDVD--------NYSASDAISM
 |. |.  |.. .   .   .  .. | | | .  . ...|...|.|. ..  ..|. | ||| .|..|||..|. ...           .... .|...
tleltnlgytgesrtvth..fhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkr

FEYYRGHPMEREHYKKSLYEA
.  .| .  . .   . .|||
lreqRpgmvqtleqyrfvyea
0050432 (Phosphotyrosine protein) phosphatases II 107-200 2.3e-12 42.3 In-house 184-294 (308) alignment 
Range on Protein: 107-200
Range on HMM: 184-294/308.0
K-----------------YLKLNCPGHEVNEREDLVQDFINAVKEFVndkenDGKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYR
                  .  .|.| | | .  . . ||...|...      .|. | ||| .|..||| .|. ...        . .. .|. ..  .|
rtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR

GHPMEREHYKKSLYEA
 .  . . . . ||.|
pgmvqtpeqylflyra
0047943 (Phosphotyrosine protein) phosphatases II 102-199 3.5e-12 41.8 In-house 165-266 (273) alignment 
Range on Protein: 102-199
Range on HMM: 165-266/273.0
ADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNDKENDgKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKS
  .   .. .. | | | .  . . .||..|... .   .. . . ||| .|..||| .|. ...        . .. .|. ..  .| .  . . . . 
srtvthfhytgwpdhgvppslesllefielvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrf

LYE
|||
lye
0051299 (Phosphotyrosine protein) phosphatases II 88-198 7.6e-12 40.7 In-house 122-279 (288) alignment 
Range on Protein: 88-198
Range on HMM: 122-279/288.0
DLTNTDR--------Y-------------------------------------YKKTEWADHGVKYLKLNCPGHEVNEREDLVQDFINAVKEFVNdkeND
 ||...         |                                     .....   .   .  .| | | | .  .|. ||...|... .   ..
mltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala...sg

GKLIGVHCTHGLNRTGYLICRYMI-----DVDNYSASDAISMFEYYRGHPMEREHYKKSLY
|. . ||| .|..||| .|. ...          .. .|. ..  .| .  . .   . .|
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvy
0036941 (Phosphotyrosine protein) phosphatases II 108-205 2.1e-11 39.1 In-house 173-277 (297) alignment 
Range on Protein: 108-205
Range on HMM: 173-277/297.0
YLKLNCPGHEVNEREDLVQDFINAVKEFVnDKENDGKLIGVHCTHGLNRTGYLICRYMI--------DVDNYSASDAISMFEYYRGHPMEREHYKKSLYE
.  .. | | | |  . . |||..|...  .. ..|. . ||| .|..|.| .|. ...           ...  .|. ..  .| .  . .   . |||
fhytgwpdhgvpespaslldfielvrkvl.kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflye

AERKKK
|. .  
allell
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 81-204 3.8e-11 36.7 In-house 30-147 (148) alignment 
Range on Protein: 81-204
Range on HMM: 30-147/148.0
KQIGLViDLTNTDRyYKKTEWADHGVKYLklNCPGHEvNEREDLVQDFiNAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF
|..|.   . |. .  ..  ....|..||  ... .. ...||| . | . . .||. ....|. . ||.. |  |   |   ..|| .. |  .|. . 
kalgvt.rivnatk.erdnaldqrgieYl..hvaldD.kpkedlsaiF.ediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalv

EYYRGHPMEREHYKKSLYEAERKK
.  | .  ..  . | |.| |...
kskrryvdpnlgfLkqLaeleqae
subfamily_PTEN_pd Subfamily PTEN 92-185 5.3e-10 34.6 In-house 69-157 (184) alignment 
Range on Protein: 92-185
Range on HMM: 69-157/184.0
TDRYYKKTEWadhGVKYLKLNCPGHEVNeREDLVQDFINAVKEFVNdkENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSAS-DAISMFEYYRG
..|.|....      .  ....  |.   . .|...... ......  |.. ... |||  |  ||| ||. |..    .. . .|...|.  | 
serkydskkf...dgrvavypfdDhnpp.plelleeivediekwle..edkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_PTPDC1_pd Subfamily PTPDC1 68-185 9.7e-10 33.2 In-house 46-156 (182) alignment 
Range on Protein: 68-185
Range on HMM: 46-156/182.0
GVKTLISLAQQANKQ-IGLviDLTNTDRYYKKTEWADHGVKYLKLNCPGHEVNEREDLVqDFINAVKEFVndkeNDGkLIGVHCTHGLNRTGYLICRYMI
|.|..| | .. .    |    | ..   |.. .....|. . ..  . ..|.  | .. | .  |.  .    ..|  ..|||  || ||| ||. |..
gikavinLqekgehasCGa..gleesGfsYdlealmeqgiyvynfgwkDygvasleriL.divkvvafal....qeg.kvavhChaGlGrtGvliacylv

DVDNYSASDAISMFEYYRG
 .....|..||..    | 
yakrltaekaiklvrskrp
subfamily_PTPMT1_pd Subfamily PTPMT1 98-199 2.7e-09 31.7 In-house 66-163 (171) alignment 
Range on Protein: 98-199
Range on HMM: 66-163/171.0
KTEWADHGVKYLKLNCPGHE-VNEREDLvqdfINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKS
. ||  .||..|.|. . .    ..|.|     ..| ||...  ..|| . |||  |  |.. |.  |..  .. |  .|... .  | .   ...  | 
teewkklgveqlqlatvDfteapdlekl....ekgv.efiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwka

LYE
|.|
lqe
subfamily_DSP23_pd Subfamily DSP23 125-197 2.9e-09 31.8 In-house 70-138 (148) alignment 
Range on Protein: 125-197
Range on HMM: 70-138/148.0
VQDFINAvkefVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHPMEREHYKKSL
|..|..     |.. |. .. ..|||  |  ||| ..  |..   . .|..||.     |   .|    .| .
vvefvrv....veeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsvetveqeklv
subfamily_VSP_pd Subfamily VSP 93-192 6.2e-09 30.1 In-house 84-178 (212) alignment 
Range on Protein: 93-192
Range on HMM: 84-178/212.0
DRYYKKTEWaDHGVKylKLNCPGHEVNEREDLVQdFINAVKEFVNDKENdgKLIGVHCTHGLNRTGYLICRYMIDVDNYS-ASDAISMFEYYRGHPMERE
.| | .. . .. ||  ...   |.| . |.|.. | . |||.... ..  ... .||  | .||| ..| ...  . .. | ...  |   | .  | |
eraydekyf.nnrvk..riliddhnvpkleellv.ftkevkewlekdlk..nvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktege

H
.
k
subfamily_CDC14_pd Subfamily CDC14 81-181 1.3e-08 29.1 In-house 211-301 (328) alignment 
Range on Protein: 81-181
Range on HMM: 211-301/328.0
KQIGLVIDLTNTdrYYKKTEWADHGVKYLKLNCPGHEVNErEDLVQDFINAVKEFvndkendGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF
...  |. | .    |..... |.|...  |      . . . .|. |......           | |||  || ||| ||  |..   ...|..||. .
nnvttvvrLnkk..lYdakkftdaGfdhkDlffiDGstPs.daivkkfleiaeka.......eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawl

E
 
r
subfamily_DSP12_pd Subfamily DSP12 78-183 1.7e-08 29.0 In-house 23-122 (155) alignment 
Range on Protein: 78-183
Range on HMM: 23-122/155.0
QANKQIGLVIDLTNTDRYYKKTEWADHGvkYLKLNCPGhevNEREDLVQDfINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAI
... .|  |. .....    |...      ......     ...||...  .. . .|...  .... . |||. |. |   ..  |..  .. | ..|.
lkelkithvlsvikeelpehklkkgkvs..tkfiqilD...epeediLsh.ldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAl

SMFEYY
.. .  
klvkek
subfamily_DSP10_pd Subfamily DSP10 81-180 1.6e-07 25.3 In-house 38-129 (159) alignment 
Range on Protein: 81-180
Range on HMM: 38-129/159.0
KQIGLVIDLTNTDRyykkTEWADHGVKYLKLNCpghEVNEREDLVQDFINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMF
 .|  |...|..      .|......|| ...    . .....| | | .|. ||...  . |. . |||  |. |   ..  |..   | | .||  . 
lnitavlnvttsvP....nefeeealkYkripv...sDtskqnlkqyfeeal.efieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfv
subfamily_DSP1_pd Subfamily DSP1 107-184 4.8e-07 24.0 In-house 63-136 (163) alignment 
Range on Protein: 107-184
Range on HMM: 63-136/163.0
KYLKLNCpghEVNEREDLVQDFiNAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYR
.| ||.    | ....|. . | . | ||... .. .  . .||  |. |   |.  |..  ...| ..|  .    |
eYkklkl...eDspkadislvf.eeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrR
subfamily_DSP19_pd Subfamily DSP19 120-185 6.8e-07 23.7 In-house 66-131 (152) alignment 
Range on Protein: 120-185
Range on HMM: 66-131/152.0
EREDLVQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRG
. |  . ...... .|...  .    . |||  |  |.  ..  |..   . | ..|...    | 
lpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp
subfamily_DSP6_pd Subfamily DSP6 82-179 1.7e-06 21.7 In-house 39-129 (158) alignment 
Range on Protein: 82-179
Range on HMM: 39-129/158.0
QIGLVIDLTNT-DRYYKKTEwadhGVKYLKLNCPGHevnEREDLVQDFINAVkEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISM
.|  |...|.  .  .....     .|||..    |     ..| . | .|. ||...  .. . . |||  |. |.  ..  |..   ..|  ||  .
kikyvlnvtsnlpnkfeesg....elkylqipiedh...lsqnlakffPeai.efidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydl
subfamily_PRL_pd Subfamily PRL 93-182 1.9e-06 22.0 In-house 43-128 (151) alignment 
Range on Protein: 93-182
Range on HMM: 43-128/151.0
DRYYKKTEWADHGVKYLKLNCPGHEVnEREDLVQDFINAVKEFVndKENDGKLIGVHCTHGLNRTGYLICRYMIDVdNYSASDAISMFEY
.  |....  ..|.. | |.     |   |..|..... .||    ||. .. ..|||  || |.  |..  .|.    .  ||...   
eptydteklekegievldlafddGav.PpeevveeWlellkekf..keepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefire
Y_phosphatase Protein-tyrosine phosphatase 94-165 2.9e-06 22.3 Pfam-A 136-192 (235) alignment 
Range on Protein: 94-165
Range on HMM: 136-192/235.0
RYYKKTEWADHGvkylklnC--PghevneredlVQ---DFINAVKEFVndkENDGKLIGVHCTHGLNRTGYLICRYM
. .  |.| |||       .             ..   |.|..|..     |.. . . ||| .| .||| ...  .
kqlhytnWpdhg.......vpes..........pkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldi
Y_phosphatase Protein-tyrosine phosphatase 94-165 2.9e-06 22.3 In-house 136-192 (235) alignment 
Range on Protein: 94-165
Range on HMM: 136-192/235.0
RYYKKTEWADHGvkylklnC--PghevneredlVQ---DFINAVKEFVndkENDGKLIGVHCTHGLNRTGYLICRYM
. .  |.| |||       .             ..   |.|..|..     |.. . . ||| .| .||| ...  .
kqlhytnWpdhg.......vpes..........pkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldi
subfamily_DSP15_pd Subfamily DSP15 125-187 2.9e-06 21.5 In-house 60-122 (151) alignment 
Range on Protein: 125-187
Range on HMM: 60-122/151.0
VQDFINAVKEFVNDKENDGKLIGVHCTHGLNRTGYLICRYMIDVDNYSASDAISMFEYYRGHP
.. |..   ||. .    .. . |||  |. |   |.  |.. | ...  ||... .. |   
lskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsva
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 108-185 4.2e-06 21.0 In-house 183-257 (319) alignment 
Range on Protein: 108-185
Range on HMM: 183-257/319.0
YLKLNCPGHEVNEREDLVQDFINAVKEFVNDKENdgKLIGVHCTHGLNRTGYLICrYMIDVDNYSASDAISMFEYYRG
.  .. | |.| |.  .. |... ... .. ...  . | |||  |  |||  |    . ... .   .. .|.. . 
fqyteWpdhdvPekatslldllkrirksrektqs..gPivvhCsaGvGRtGtfiv.ldamlervkeegvlDvfstvsr
subfamily_PTPRB_pd Subfamily PTPRB 111-181 4.4e-06 20.9 In-house 187-255 (293) alignment 
Range on Protein: 111-181
Range on HMM: 187-255/293.0
LNCPGHEVNEREDLVQDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLICRYMIdVDNYSASDAISMFE
.  | |.| |. . . ||...|.| ........ .. |||  |. ||| .|.  .. ... . .| . .| 
tsWpdhgvPektktlldfvrtvreaiektaskrPiv.vhCsaGvGRtGtfialdrl.lqaieeedyvdifg
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 95-162 5.1e-06 20.7 In-house 156-216 (270) alignment 
Range on Protein: 95-162
Range on HMM: 156-216/270.0
YYKKTEWADHGVKYLKlncpGHeVNEREDLVqDFINAVKEFVNDKENDGKLIgVHCTHGLNRTGYLIC
 .  ..| ||||   .    .. . . ..|.   ..||... ..... . |. |||. |..||| || 
HfwyntWpdhgvpree....ds.slstdqll.kmlravrrsekeldkaePll.vHcsaGvgRtGtlia