Gene W03F11.4 in Caenorhabditis elegans

Synonym: CELE_W03F11.4, W03F11.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf7
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP199_AA protein Get Run
CeleP199_AA_923-1227 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 925-1240 1.8e-173 569.9 In-house 1-302 (302) alignment 
Range on Protein: 925-1240
Range on HMM: 1-302/302.0
IGADRKLHRTAGEFFHEYFEHGYEMCKKKTGNLLEKDVSERRKQMFICYPQTMPKLVDFNNDrFINANLMEIDGVKWIMTQGPMDGTEHVqeekknaekr
|||||||..|..|.|.||.|...|..||||...||||.|||||..|||.|.||.|||||.|| |||||....|..||||.||||||||..          
igadrklnktlleefleyveraleklkkktstnlekdiserrkslficepktmaklvdfknd.finanvlkldeikwimaqGpmdGtekk..........

ksgEKVSKKPIVPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQFTDKQTAKVYTIEFHNNKVLMKV
   ||||||||||||.|.||.|..||.|....|.|||.|.||.|.|||||||..|.||.||||||||||||...|..||||...|.||.|..|.|. .||
...ekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkv

PFPVKILAFSGWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
...|.|||||.|||||||.|..|||||.|.|||.|.|||||||.||||||||||||||||||||..|.|....|.|||.|||||||.||||||.|||.||
kktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk

ALMEKAGVLFWDNYNA
.||||||||......|
glmekagvlylrsfda
0040438 (Phosphotyrosine protein) phosphatases II 959-1263 2e-54 180.4 In-house 41-310 (317) alignment 
Range on Protein: 959-1263
Range on HMM: 41-310/317.0
EKDVSERRKQMFICYPQTMPKLVDFNN---DRFINANLMEID--GVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFWGMIEEYR
..  . .|   ...|...  || ....   . .|||.....   . |.|.||||.                              ..| |.|| |. |..
penkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl..............................pntvedFwrmvweqg

TGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNkvLMKVPFPVKILAFSGWPDHGAPAEPHTALDIIK
..|.  |....|.| .|||.|...  ......|..||...|.||       ..  ...|.|. ..    . .. |... . ||||||.|  | . ||...
vtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.......lagitlrtlevedl..gdsesrtvthfhytgWpdhgvppspdllldfle

YCESF----KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEKAGvlfWDNYNALHYYYDKLQ
.....    .. |||||| |||||||..|. . .... | .  |.  .|. .|..|.|||||..|....  .. . |. |     . ... |.....||.
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt...lepaselklkllkll

TDYYEPYLKKDEKD
. .. .  | .||.
iplalddvklkeke
0036941 (Phosphotyrosine protein) phosphatases II 960-1235 4.4e-53 175.9 In-house 38-286 (297) alignment 
Range on Protein: 960-1235
Range on HMM: 38-286/297.0
KDVSERRKQMFICYPQTMPKLvDFNNDRFINANLMEIDG--VKWIMTQGPMDgtehvqeekknaekrksgekvskkpivpkkDTREKFWGMIEEYRTGVV
. ..  |   ...|..|. || | ... .|||..... .   |.|.||||..                              .| |.|| |. |... |.
enleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlp..............................ntvedFWrmvweqnvtvI

AQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENldqftDKQTAKVYTIEFHNNkvLMKVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCES
  |... |.| .|||.|...|. .....|..||...|||.      .... ...|.|  ..    . .. |... . ||||||.|  | . ||.|.....
vmltelvelgrekcaqywpleegesltygdftvtllsvevv.....llddytlrtlevtdt..gngesrtvthfhytgwpdhgvpespaslldfielvrk

------FKTNVLVHCSVGVGRTGTLVAIKYGIQLCS---KQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEKAGVLFW
       .. |||||| ||||.||..|. . .|.     |..  |.  .|  .| .|.|||||..|....  .. . |. |  .. .
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl
Y_phosphatase Protein-tyrosine phosphatase 964-1223 7.8e-52 171.4 Pfam-A 4-234 (235) alignment 
Range on Protein: 964-1223
Range on HMM: 4-234/235.0
ERRKQMFICYPQTMPKLVDFNN-DRFINANLM---EiDGVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFWGMIEEYRTGVVAQ
 .| .....| .|. || . ..   .|||| .   . .  |.|.||||.                              |.| |.|| |. .... |...
knRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPl..............................kstiedFWrmvwqekvkvivm

LCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVsveenLDQFTDKQTAKVYTIEFHNNK--VlmkVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCES
|.. .| |..|||.|...| ......|...|...      .. .|..   ....| ...|       .. || | . .|||||.|..|.  ||.|. .|.
ltsleekgrekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvek

FK----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCIT
 |    ..|.|||| |||||||.||... .. ....|  |.  .|  .|..| |.||...|.|..  .|.
skeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 964-1223 7.8e-52 171.4 In-house 4-234 (235) alignment 
Range on Protein: 964-1223
Range on HMM: 4-234/235.0
ERRKQMFICYPQTMPKLVDFNN-DRFINANLM---EiDGVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFWGMIEEYRTGVVAQ
 .| .....| .|. || . ..   .|||| .   . .  |.|.||||.                              |.| |.|| |. .... |...
knRykdilpydktrvklkgsegpsdYInAnyvkgyk.ekkkfIatQgPl..............................kstiedFWrmvwqekvkvivm

LCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVsveenLDQFTDKQTAKVYTIEFHNNK--VlmkVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCES
|.. .| |..|||.|...| ......|...|...      .. .|..   ....| ...|       .. || | . .|||||.|..|.  ||.|. .|.
ltsleekgrekcaqYwpeeeeesltygdikvelk.....ekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvek

FK----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCIT
 |    ..|.|||| |||||||.||... .. ....|  |.  .|  .|..| |.||...|.|..  .|.
skeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0050432 (Phosphotyrosine protein) phosphatases II 962-1227 1.2e-51 171.2 In-house 69-300 (308) alignment 
Range on Protein: 962-1227
Range on HMM: 69-300/308.0
VSERRKQMFICYPQTMPKLvDfNNDRFINANLMEID----GVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFWGMIEEYRTGVV
..  |   ...| ..  || | ... .|||... .       |.|.||||.                              ..| |.|| |. |... |.
kdkNrykdilpydhsRVkl.d.egsdYInAsyvdgyssklprkfIatqgPl..............................pntvedFwrmvweqnvrvI

AQLCQFKEDGENKCAEYYSTEVK-GEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNKVLmkVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCE
  |... |.| .|||.|. .|.. | ...|..||...|.|.       ... .|.|.|  |..      . |... . .|||||.| .|   ||......
vmLtklvengrekcaqYwplelgggsleygkftvtllseev.......lddytvrtleltnlgdg..esrtvthfhytnWpdhgvPpspeilldflelvr

SF--KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALM
..  . ...|||| |||||||..|. . ...  |.   |.  .|  .| .|.|.|||..|....  .. . |.
kslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0045450 (Phosphotyrosine protein) phosphatases II 924-1227 2e-50 167.7 In-house 14-305 (307) alignment 
Range on Protein: 924-1227
Range on HMM: 14-305/307.0
SIGADRKLHRTAGEFFHEYFEHGYEMCK----KKTGNLLEKDVSERRKQMFICYPQTMPKLVDFNN----DRFINANLMEI----------DGVKWIMTQ
.. . ..|...  . ... ||. .....    . .  ||..  . .| . ...|..|  || . ..    . .|||. . .           . |.|.||
llllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

GPMDGtehvqeekknaekrksgekvskkpivpkkdTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKGEMKFGRYTVKTVSVEEnldqftdK
||...                              | |.|| |. |....|.  |....|.| .|||.|...| ..|. .|..||...|.|.       .
gPlpe..............................tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.......l

QTAKVYTIEFHNnkV-LMKVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCES------FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEV---SDMA
.  .|.|.| ..      . .. |... . ||||||.|  . ..||.|.....       .. |||||| |||||||..|. . ...  |...    |. 
dgytvrtlevtd..ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdll

LVVDPVRACRYGAVQTEQQLIYMLLCITKALM
 .|. .|..|.||||...|...   .. . |.
eavkllreqRpgavqnpeqyrflyeallelll
DSPc_SM00195 952-1226 2.6e-50 166.5 In-house 17-262 (263) alignment 
Range on Protein: 952-1226
Range on HMM: 17-262/263.0
KKTGNLLEKDVSERRKQMFICYPQTMPKLVDFN---NDRFINANLMEID--GVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFW
..| .  .| .|  | .....| .|  || . .   .. .|||| ....    |.|.||||.                              ..| |.||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl..............................pstvedFW

GMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLdqftdkQTAKVYTIEFHNNKVlmKVPFPVKILAFSGWPDHGAPAEPH
 |. | .. ... |....|.|..||..|.  | .|...||...||.|.||.        .  ...|.|  ...   . .. |. . . .|||||.| ...
rmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstk

TALDIIKYCESFKT----NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
  |........ |      ..|||| |||||||.|.|.. .. .....  |.  .|  .|  | |.|||..|....  .| ...
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 952-1226 2.6e-50 166.5 In-house 17-262 (263) alignment 
Range on Protein: 952-1226
Range on HMM: 17-262/263.0
KKTGNLLEKDVSERRKQMFICYPQTMPKLVDFN---NDRFINANLMEID--GVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFW
..| .  .| .|  | .....| .|  || . .   .. .|||| ....    |.|.||||.                              ..| |.||
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl..............................pstvedFW

GMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLdqftdkQTAKVYTIEFHNNKVlmKVPFPVKILAFSGWPDHGAPAEPH
 |. | .. ... |....|.|..||..|.  | .|...||...||.|.||.        .  ...|.|  ...   . .. |. . . .|||||.| ...
rmvweekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkk......deiilrtleltkegk..eetrkvtqyqyknWpdhgvpdstk

TALDIIKYCESFKT----NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
  |........ |      ..|||| |||||||.|.|.. .. .....  |.  .|  .|  | |.|||..|....  .| ...
svlellravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0047943 (Phosphotyrosine protein) phosphatases II 962-1224 3.2e-49 163.2 In-house 39-270 (273) alignment 
Range on Protein: 962-1224
Range on HMM: 39-270/273.0
VSERRKQMFICYPQTMPKLvDFNNDRFINANLMEI--DGVKWIMTQGPMdgtehvqeekknaekrksgekvskkpivpkKDTREKFWGMIEEYRTGVVAQ
 .  | . ...| ... || . ... .|||....    . |.|.||||.                              ..| |.|| |. |... |.  
kdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPl..............................pntvedfwrmvweqnvrviVm

LCQFKEDGENKCAEYYSTEVKG-EMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNKvlMKVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCES-
|... |.| .||| |...|. . ....|..||...|.|.       |.. .|.|.|  |..   . .. |... . ||||||.|. .   |..|..... 
LtelvelgrekcaqYwpleggelsltygkftvtllseet.......kddytvrtleltnlg..tgesrtvthfhytgwpdhgvppslesllefielvrka

-----FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
      .. |.|||| |||||||..|. . ...  |    |.  .|  .| .|.|.|||..|....  .. .
lealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0045098 (Phosphotyrosine protein) phosphatases II 952-1226 4e-48 159.6 In-house 24-272 (278) alignment 
Range on Protein: 952-1226
Range on HMM: 24-272/278.0
KKTGNLLEKDVSERRKQMFICYPQTMPKlvdfnnDrFINANLMEIDGVKWIMTQGPMDgtehvqeekknaekrksgekvskkpivpkkDTREKFWGMIEE
. | .|......  |   ...|.... |      | .|||..... . |.|.||||..                              .| ..|| |. |
eitpalylgnldknRykdilpydhsrVk......d.YINAsyidgypkkfIatqgPlp..............................stvadfwrmlwe

YRTGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVEENldqftDKQTAKVYTIEFHNNKVLMKVPFPVKILAFSGWPDHGAPAEP--HTAL
... |.  |....|.| .|||.|.    .| . .|..||...|.|..     |. |  .....  ...     .. |..| . .|||||.| .|     |
lgitvivmltelvelgrekcaqywpe..ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksfl

DIIKYCES-----------------FKTNVLVHCSVGVGRTGTLVAIKYGIQLCskQEVSDMALVVDPVRACRYG-AVQTEQQLIYMLLCITKAL
........                  .. |||||| ||||||||||. . ..|.  ... |.  .|. .| .| | |||...|....  .. . |
ellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
0039614 (Phosphotyrosine protein) phosphatases II 934-1228 1e-47 158.4 In-house 29-291 (297) alignment 
Range on Protein: 934-1228
Range on HMM: 29-291/297.0
TAGEFFHEYFEHGYEMCKKKTGNLLEKDVSERRKQMFICYPQTMPKLVDFNN----DRFINANLMEIDGV---KWIMTQGPMDGtehvqeekknaekrks
.   .... ||. ...   ..  ||.. .. .| . ...|.... || ....    . .|||....   .   |.|.||||...                
nsktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe................

gekvskkpivpkkdTREKFWGMIEEYRTGVVAQLCQFKEDGEnKCAEYYSTEVKgemKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNnkvlMKVPF
              | |.|| |. |... |.  |....|.|  |||.|...|.    ..|..||....||.       ..  .|.|.|  |     . ..
..............tvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh.......ldgytvrtlevtn....ngesr

PVKILAFSGWPDHGAPAEPHTALDIIKYCES------FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLL
 |. . . ||||||.|  . . |........       .. |||||| |||||||..|. . .... |    |.  .|. .| .|.|||||..|...   
tvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflyd

CITKALME
.. . |. 
allellkr
0046845 (Phosphotyrosine protein) phosphatases II 953-1228 1.3e-47 157.9 In-house 20-276 (284) alignment 
Range on Protein: 953-1228
Range on HMM: 20-276/284.0
KTGNLLEKDVSERRKQMFICYPQTMPKLVDFNN----DRFINANLMEID-------GVKWIMTQGPMDgtehvqeekknaekrksgekvskkpivpkkDT
 .  ||.. .|  | . ...| ..  ||  ...    . .|||....           |.|.||||..                              .|
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlp..............................nt

REKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKGEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNKVlMKVPFPVKILAFSGWPDHGA
 |.|| |. |... |.  |... |.| .||| |...| .. ...|..||...|.|.       |.. .|.|.|  |...  . .. |... . .|||||.
vedFwrmvweqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.......kddytvrtleltnlgy.tgesrtvthfhytswpdhgv

PAEPHTALDIIKYCESF------KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQE---VSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
|..|   |.........      .  ..|||| |||||||..|. . ...  |..   . |.  .|  .| .|.|.|||..|...   ..  .|. 
ppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
0051299 (Phosphotyrosine protein) phosphatases II 957-1225 1.9e-47 157.5 In-house 45-285 (288) alignment 
Range on Protein: 957-1225
Range on HMM: 45-285/288.0
LLEKDVSERRKQMFICYPQTMPKLVDFNN---DRFINANLMEI--DGVKWIMTQGPMDgtehvqeekknaekrksgekvskkpivpkkDTREKFWGMIEE
||.. ..  | . ...| ..  || ....   . .|||.....   . |.|.||||..                              .| |.|| |. |
llpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp..............................ntvedFWrmvwe

YRTGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNKV--LMKVPFPVKILAFSGWPDHGAPAEPHTAL
... |.  |... |.| .||| |...  .| ...|..||...|.|.       ... .|.|.|  |...    . .. |... . .|||||.|  |   |
qnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev.......lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspelll

DIIKYCESF----KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKA
|..... ..    .  |.|||| |||||||..|. . ...  |... |.  .|  .| .|.|.|||..|...   ..  .
dflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0040439 (Phosphotyrosine protein) phosphatases II 958-1226 1.4e-45 151.2 In-house 8-246 (249) alignment 
Range on Protein: 958-1226
Range on HMM: 8-246/249.0
LEKDVSERRKQMFICYPQTMPKLVDFNN---DRFINANLMEID--GVKWIMTQGPMDGtehvqeekknaekrksgekvskkpivpkkdTREKFWGMIEEY
|..... .| . ...|.....|| ....   . .|||....    . ..|.||||...                              | |.|| |. |.
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..............................tvedfwrmlwel

RTGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNkvLMKVPFPVKILAFSGWPDHGAPAEPHTALDII
. .|.  |....| | .|||.|...  .|....|..||...|||.       |.  .|.|.| .|.    . .. |. . . .|||||.|  . ..||.|
gitvivmLtslvelgrekcaqywpl..ggsleygdftvtllsvev.......kddytvrtleltnl..ydgesrtvlhiqytdwpdhgvppsfedlldfi

KYCES------FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
.....       .. |||||| |||||||..|. . ...  |    |.  .|. .| .|.||||...|... . .. . |
eavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0043336 (Phosphotyrosine protein) phosphatases II 956-1222 1.8e-45 151.0 In-house 40-273 (278) alignment 
Range on Protein: 956-1222
Range on HMM: 40-273/278.0
NLLEKDVSERRKQMFICYPQTMPKLVDFNN---DRFINANLMEID--GVKWIMTQGPMDGtehvqeekknaekrksgekvskkpivpkkdTREKFWGMIE
 ||.. .. .|   ...|.... || ....   . .|||....    . |.|.||||...                              | |.|| |. 
allpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe..............................tvedFwrmvw

EYRTGVVAQLCQFKEDGENKCAEYYStevKGEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNnkVLMKVPFPVKILAFSGWPDHGAPAEPHTALD
|... ..  |....|.| .|||.|..   .| ...|..||.....|.       ... .|.|.| .|     . .. | .. . ||||||.|  . . ||
elgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.......lddytvrtlevtn..lgdgesrtvthyhylgwpdhgvpeslsllld

IIKYCES----FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCI
..|.  .     .. |||||| |||||||..|. . ...  |    |.  .|. .| .|.|||||..|...   ..
flkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0042113 (Phosphotyrosine protein) phosphatases II 960-1223 2.3e-42 140.5 In-house 8-240 (245) alignment 
Range on Protein: 960-1223
Range on HMM: 8-240/245.0
KDVSERRKQMFICYPQTMPKLVDFNND---RFINANLMEID---GVkWIMTQGPMDGtehvqeekknaekrksgekvskkpivpkkdTREKFWGMIEEYR
.... .|   ...|..|. || . ..|    .|||...  .   .  .|.||||...                              | |.|| |. |..
enkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk.fiatqgPlpe..............................tvedfwrmlwelg

TGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVEEnldqftdKQTAKVYTIEFHNNkvLMKVPFPVKILAFSGWPDHGAPAEPHTALDIIK
  ..  |... |.| .|||.|...  ......|..||...|.|        ... .|.|.| .|.    . .. |  . . .|||||.|  . . ||...
ittivmLteeeelgrvkcaqywpl..gesltygdftvtllseeh.......lddytvrtlevtnl..gddesrevihyhylpwpdhgvpdllellldfle

YCES-----FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCIT
....      .. |||||| |||||||..|. . ...  |    ..  .|. .| .|.|||||..|....  .. 
fvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0037934 (Phosphotyrosine protein) phosphatases II 957-1222 5.6e-42 139.3 In-house 6-238 (243) alignment 
Range on Protein: 957-1222
Range on HMM: 6-238/243.0
LLEKDVSERRKQMFICYPQTMPKLvdfNNDRFINANLMEIDGvKWIMTQGPMDGTEhvqeekknaekrksgekvskkpivpkKDTREKFWGMIEEYRTGV
||. ..|..| . ...|.... ||   ... .|||||... . ..| ||||...|                           .|. ..|| |. |....|
llpenlsknrysdilpydhsrvkl...egsdyinanliyvtp.rliatqgPlpetv..........................eddlasfwrmlwelgitv

VAQLCQFKEDGENKCAEYYStevkGEMKFGRYTVKTVSVEEnldqfTDKQTAKVYTIEFHNNKVLMkvpFPVKILAFSGWPDHGAPAEPHTALDIIKYCE
.  |....| | .|||.|..    ||. .|..||...|.|.     .|. |  ....| .. . |    . |  . . .|||||.| .|   ||..... 
ivmltelvElgrekcaqywp....gevtygdftvtllseeh.....lddytvrtlllenldlddlt...rlvihyhylpwpdhgvPdspedlldfldevr

SF------------KTNVLVHCSVGVGRTGTLVAIKYGIQLCskqEvSDMALVVDPVRACRYG-AVQTEQQLIYMLLCI
.|            .  |||||| ||||||||.|. . ..|.   .  |.  .|. .|..| | ||||..|...   ..
efieellsllaldsggpvlVHCsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_PTPRB_pd Subfamily PTPRB 1037-1229 7.5e-31 102.2 In-house 102-288 (293) alignment 
Range on Protein: 1037-1229
Range on HMM: 102-288/293.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgEMKFGRYTVKTVSvEENLDQFTDKQtakvYTIEFhnnkvlMKVPFPVKILAFSGW
|  .|...|| |. | .. ..  | |  | |  || ||. .. . .. .|  .|. |. ||.|.... ..    ..||        |    |. . |  |
PlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadee.pvlyGdikvtlva.eeeledwvire....lkiek......ekeerkvrqyhftsW

PDHGAPAEPHTALDIIKYCESFK------TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEK
|||| | ...| ||...  .. .      . ..|||| |||||||..|..  .|  ..... |.. .|  .|  |   ||||.| |..  |. . |..|
pdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_PTPRD_pd Subfamily PTPRD 1037-1230 4.3e-30 99.9 In-house 99-285 (564) alignment 
Range on Protein: 1037-1230
Range on HMM: 99-285/564.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKgEMKFGRYTVKTVSvEENLDQFTdkqtakVYTIEFhNNKVLMKVpFPVKILAFSGW
|...| | || |. |... ..  | . .| |..||..|. .. . . ..|..||. .. ||.| ...      . |..  ..|  ...   |.   |  |
PlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtlee.eeeladye......irtfkl.kkkksses.reVrqFhFtsW

PDHGAPAEPHTALDIIKYCESFKT----NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEKA
||||.| .. . ||.|. ... ..     ..|||| ||||||| ..|.. ..   .... |.  .|  .|. |   ||||.| |..   | .||    
PdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1037-1218 5.3e-30 99.6 In-house 97-275 (305) alignment 
Range on Protein: 1037-1218
Range on HMM: 97-275/305.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSvEENLDQFTDKQTAKVYTIEfhnnkvlMKVPFPVKILAFSGW
| |.| . || .| |... .. .|.. .|.|..||  |. .... ...||...|.  | |..  ... ..       |        |    |  . .  |
PlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelks.ektasdyieRklkisiede.......dkesrtvlqyqltdW

PDHGAPAEPHTALDIIKYCESF-----KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYM
|||| | .. . |..||  .       .. .||||| ||||||. .|..  .. . | || |.. |.  .|  | ..||| .|  ..
PdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvfl
subfamily_PTPN12_pd Subfamily PTPN12 1037-1227 1.7e-29 97.6 In-house 91-278 (290) alignment 
Range on Protein: 1037-1227
Range on HMM: 91-278/290.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSvEEnldQFTDKQTAKVYTIEFHNNKVLmkvpfpVKILAFSGW
|  .| . || || |... .|  .|.  | | .||. |.. |.. |..|| ..|.. . |.   ...|  . .  ..|.....        |. . .  |
PLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtlee.ek...avdddflirtLkveaqkesrk......vyqfhYtaW

PDHGAPAEPHTALDIIKYCESFKT----NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEV---SDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALM
|||| |. ... |..|.  .....     ..|||| |||||||..|| |  .|  .. .    |.  .|  .|  |  .|||..|  ..  .... . 
PDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1037-1222 1.2e-28 94.9 In-house 99-279 (290) alignment 
Range on Protein: 1037-1222
Range on HMM: 99-279/290.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKGEMkFGRYTVKTvSVEENLDQFTDKqtakvyTIEFHNNKVLmKVPFPVKILAFSGW
| ..|  .|| .| . .. ..  |.. .|.|..||  |.... . .. .| ...|  . ||.|.... .      ..| .|..   . .  |. . .. |
pvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikl.lneetlneyier......klevknknsa.gakqsvtqyqitnw

PDHGAPAEPHTALDIIKYCES-----FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCI
...|  ..|.| | .|.  .       .| ..|||| .|||.....|.. .|. | .. | |.  |.   | .. | |||.||. ..   .
dstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqiv
subfamily_PTPN13_pd Subfamily PTPN13 1037-1226 2.2e-28 94.3 In-house 85-269 (273) alignment 
Range on Protein: 1037-1226
Range on HMM: 85-269/273.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMK-FGRYTVKTVSVeENLDQFTdkqtakVYTIEFHNNKVLMKvpFPVKILAFSG
|  .| . || |. | .. |.| . . ||.|. ||  |.  . . ..|  .|..|. . | ..||.|.      | ... ....        |  | |  
PlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkv.qkldgfv......vralavkdsesges..revahlnfvk

WPDHGAPAEPHTALDIIKYCESFKT---NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
||||| |...   | ....  ...|    ..|||| |.||.|||..|.  ..| ....  |.  .|  .|  | | |||..| |..   | ..|
wPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1037-1219 4.1e-27 89.6 In-house 102-276 (290) alignment 
Range on Protein: 1037-1219
Range on HMM: 102-276/290.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVkTVSVEENLDQFTDKQTAKVYTIEFHNNKVLMKvpfpvkiLAFSGW
. |||   .| |. . .. ..  ||.  |||  ||..||  .    . || .|| . | |.. |. . |.|  |   .   ...| .       |    |
alkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitv.lcseeddkdaniikktlsvrdkdsGkehklkh.......lkiksw

PDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
||.  .    . | ...        | |||| |.|||||.|||. |.|.  .    |.. .|  .| .| ..|| . | . ..
pdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalv
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 985-1228 4.5e-27 89.9 In-house 45-261 (290) alignment 
Range on Protein: 985-1228
Range on HMM: 45-261/290.0
NDRFINANLMEI-DGVKWIMTQGPMDGTehvqeekknaekrksgekvskkpIVPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGEN----KCAEYYSTEV
|| .| || . . .|.. |.|| |   .                       .  .. | |||| |. . .   | .||.|.|  .|     ||.|. ..|
nddyiHAnrvtcpnglrliltqsPqeki.......................tekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesv

KGEMKFGRYTVKTVSVEENldqftDKQTAKVYTIEFHNNKvlmkvPFPVKILAFSGWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAI
 .|.||.  |||  | |..     |    .  ...| ...     .| |.   ..|| .  .. .. |.|..|.. .  || |.|||  |. |  .| ||
geelkfkgltvkCkskeke.....ddvetRelvvkfddee.....eftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaai

KYGIQLCS-KQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
. | |.   ...   .. |.. .|  |  |......| ...  |   ..|
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
subfamily_PTPRA_pd Subfamily PTPRA 1037-1219 7.4e-27 89.1 In-house 109-288 (330) alignment 
Range on Protein: 1037-1219
Range on HMM: 109-288/330.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkGEMKFGRYTVktvSVEENldQFTDKQTAKVYTIEFHNNKVLMKVPFPVKILAFSGW
||..| | || || |...  .  | ..||  |.||| |. .|  | . .|  .|   .||..  . . . | . . ..  ...   | .  |. . | .|
PkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirv...evede..tvlvdytvrkflvqqlpdatrekksrlvrqfhftsw

PDHGAPAEPHTALDIIKYCESFK----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
|| | |.||   |...|  .. .      . |||| |||||||.....  ..    ... |.  .|  .|. |   |||..|  .. 
PdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiy
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1036-1224 1.4e-26 88.2 In-house 97-277 (288) alignment 
Range on Protein: 1036-1224
Range on HMM: 97-277/288.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgEMKFGRYTVKTVSVEEnLDQFTDKQTAKVytiefhnnkvLMKVPFPVKILAFSG
 |  || ..|| .. |..|  .. | .. |.|..|| ||. .. | . ..|  ||. |...| |..|. ..  ..            |  . .. ... .
gPladtvndfWelvyenktstivmltelveggktkCeeYWPdadk.pknyGsvtvtlveske.ledfvlrkllle..........kkkteleitqyqyla

WPDHGAPAEPHTALDIIKYCESFK----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
||||| |.  .  |....  .  .     ...|||| ||||||| .|..  |.   .... |.| .|  .|  |   |||..| ...  .. .
WpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1036-1219 1.9e-26 87.7 In-house 71-257 (270) alignment 
Range on Protein: 1036-1219
Range on HMM: 71-257/270.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQFTDKQTAKVYtIEFHNNKVLmkvPFpvkilAFSG
 |.. | ..|| || | ..  .. . ...|.| .||. |...|.| ..|.   ..|.....|. ...  ..  ..   . ......    |      .  
gPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlv...Hf.....wynt

WPDHGAPAEPH---TALDII-------KYCESFKT--NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
|||||.| |.    .. ...       .......    .||||| ||||||||.|. ....| ....  |.. ... .|  |   ||. .|  .. 
WpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefly
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1037-1221 2e-26 87.7 In-house 94-273 (287) alignment 
Range on Protein: 1037-1221
Range on HMM: 94-273/287.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgeMKFGRYTVKTVSVEeNLDQFTDKQtakvytIEFHNNKVlMKVPFPVKILAFSGW
|  .|  .|| .|.. .  ..  ||| ||. |..| .|...|    . .| |... .. |   .... ..      .| .|..   . .  ||   .  |
PmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellnee.vnagyierk......levknknk.agdkqqvkqyqitnW

PDHGAPAEPHTALDIIKYC-----ESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLC
...|  .|| | | .|.        . .| ..|||| .|||.....|.  .|. | .. | |.  |..  |  . |.||| .| ...   
dstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindi
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1037-1229 2.7e-26 87.3 In-house 90-274 (288) alignment 
Range on Protein: 1037-1229
Range on HMM: 90-274/288.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDqftdkQTAKVYTIefHNNKVLMKVPfPVKILAFSGW
| . | |..| |. |     .  ||.. | | .| |||. ...  ....||.   .    ...|     .. || ..  ...|.  .    |||| .  |
PlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradid.....klvkvsll..riskegeekv.ivkilhlleW

PDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEK
.|.| | .  . | ...  .|..  ..||.| ||||||||. |   ..    .. . .  ..   |. |. |.|||.| .|.  |. . |. |
dddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllk
0041856 (Phosphotyrosine protein) phosphatases II 964-1227 3.7e-26 87.2 In-house 4-172 (182) alignment 
Range on Protein: 964-1227
Range on HMM: 4-172/182.0
ERRKQMFICYPQTMpklvdfnNDRFINANLMEIDGVK--WIMTQGPMDGtehvqeekknaekrksgekvskkpivpkkdTREKFWGMIEEYRTGVVAQLC
 .| . ...|....       .  .|||||.  .     .|.||||...                              | ..|. |. |.. ...  |.
knrysdilpydhsr.......dldyInanlylgslpatrfiatqgplls..............................tvadflrmlkelgittivnlt

qfkedgenkCAEYYSTEVkgemkfgrytvktvsveenldqftdkqtakvytiefhnnkvlmkvPFPVKILAFSGWPDHGAPAePHTALDIIKYCESFKTN
         .  |. ...                                             .  .  . . .|||||.|  ....||.|. ... . .
.........eelywpell.............................................erlgiqylylpwpDhgvpd.ldelldfieevleeggp

VLVHCSVGVGRTGTLVAIKygiqLCSKQEvSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALM
|||||| ||||||||||.     |. |..  ..  .|. || .| |.|.|..|...  |..   |.
vlVHCsaGvgRtgtlvaay....lmkklg.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1039-1228 5.6e-26 86.3 In-house 94-278 (281) alignment 
Range on Protein: 1039-1228
Range on HMM: 94-278/281.0
KDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYStEVKGEMKFGRYTVKTVSVEENldqftDKQTAKVYTIEFHNNKvlmkvPFPVKILAFSGWPD
 .. ..|| |. |..  ... . .  | |  ||  |.  . . |.|.| .|||... ||.      .   .....| ....     .  |. ||.  |||
PaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeek.....atyierkfkleresge.....treveqlaytaWPd

HGAPAEPHTALDIIKYC---ESFKT--NVLVHCSVGVGRTGTLVAIKYGIQLCSKQ-EVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
||.||...  |.  |     .. ||   ...||| ||||||| .|.   .. .... |  |.  ||  .|  |   |||  |  .. . . .||..
hGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
0051429 (Phosphotyrosine protein) phosphatases II 1039-1252 7.5e-26 86.8 In-house 32-247 (272) alignment 
Range on Protein: 1039-1252
Range on HMM: 32-247/272.0
KDTREKFWGMiEEYRTGVVAQLCQFKEDGENKCAEYYS----------TEVKGEMKFGRYTVKTVSVEENLDqftdkqtAKVYTIEFHNnKVLMKVPFPV
. | . || . .|..  ..  |..  | | .||  |             ..  .. .|...|...|.|  ||         ..... .. .. .. .. |
pltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld.......yilrellltl.llsagearev

KILAFSGWPDHGAPAEPhtALDIIKYCESfKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSD--------MALVVDPVRACRYGAVQTEQQLIYMLL
 .| . .|||||.| |.   |...... . . .|||||| |..||||.||. . ..  |.. . |        .. .|. .||.| ||||||.|... . 
mhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflye

CITKAlmekAGVLFWDNYNALHYYYDKLQTDY
.. ..    .  |.  ....|....| ....|
allel....lrsllsvraeyllaaldaideey
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1036-1225 1.4e-25 85.1 In-house 98-282 (319) alignment 
Range on Protein: 1036-1225
Range on HMM: 98-282/319.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgeMKFGRYTVKtVSVEENLDQFTDKQtakvYTIEFHNNKVLMkvpFPVKILAFSG
 |...| | || |. |... .|  |.. .| .. |. .|...|    ...||..|. .  ||.|...  ..     ... ....|       ||   .  
aPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf..eeyGrlivt.leeeeeledyiirk....lklnkkssevet...Revkhfqyte

WPDHGAPAEPHTALDIIKYCESFKTN-----VLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKA
||||. | .  . ||..|  .  . .     . |||| ||||||| ....  ..  ....| |.  .|  .|. |   ||...| ...   . .|
WpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1037-1227 1.9e-25 84.5 In-house 60-243 (250) alignment 
Range on Protein: 1037-1227
Range on HMM: 60-243/250.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENkCAEYYSTEVKgeMKFGRYTVKTVSVEEnldqFTDKQTAKVYTIEFHNNKVLMkvpfpVKILAFSGW
| ..| |.|| |. |. .|..  | ..|| ... . .|. .|.    |.|  ||.  | ||    |.| .. |.   . ....  .     |. | |  |
PlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka..ekyGdvtvsllskee....fadytkrklklskakkaderi.....vrqlhfvvW

PDHGAPAEPHTALDIIKYCESFKTN-----VLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALM
|| | |.. ...|...|  .. . .     |.|.|| ||||.|. .||.  ..   |..| |.  |.  .|. | .||....| ...   | ||| 
PdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1037-1229 2.5e-25 84.1 In-house 90-280 (307) alignment 
Range on Protein: 1037-1229
Range on HMM: 90-280/307.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRyTVKTVSVEeNLDQ---FTDKQTAKVYTIEFHNNKvlmkVPFPVKILAF
|...|. .|| |. . .   |  ||.  | .. || .|.  |   .. ||  . .|.||. ||       |..  .| |..    .        .. | .
plentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfge.apntisva.nlgakklapdedlinvttlkvdwaq....ksrtiqhlqw

SGWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGI-QLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEK
. |||.|.|    ||.....  .  .  |.|||| ||||.||.||| .   .. . ..  ||  .|. .|. |  |.||| | .|.   . . ..|.
enwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflel
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1037-1226 3.1e-25 84.1 In-house 107-290 (298) alignment 
Range on Protein: 1037-1226
Range on HMM: 107-290/298.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkGEMKFGRYTVktvsveenlDQFTDKQTAKVYTIEFHNNKVLMKVPFPVKILAFSGW
| . | | || |. |.  |..  | . .| .. |. .|. .|  |. ..|. ||         .   ... |.. . ... .|   .    |. | |. |
PltetvedFWrmvteedigtiVmltnleeldktkyhkywPde..gketygeitv.........sllskeefadlivrklkvskkkeekerevrqlhftsW

PDHGAPAEPHTALDIIKYCESFK-----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
||.|.|.. .. ||...  .  .     . |.|.|| ||||.|| .||.  ..   |..| |.  ||  .|. | ||||||.| ...   . .||
pdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPN3_pd Subfamily PTPN3 1037-1228 4.7e-25 83.0 In-house 92-277 (280) alignment 
Range on Protein: 1037-1228
Range on HMM: 92-277/280.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTeVKGEMKFGRYTVKTVSVEENlDQFTDKQtakvYTIefHNNKvlMKVPFPVKILAFSGW
| ..| ..|| |. | .. ..  | .  |.|  || .|. .  . |...|...||  . .|.  ..  ..     ..  ....   |   ..  | .  |
PlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedet.ksyvlre....lvl..kdke..tkeerkilqlqylaW

PDHGAPAEPHTALDIIKYCESFK----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
|||| | ...  |....  .. .    . |.|||| |.|||| |....  ..|  ..|   .  .|  .|  |   |||..|  ..  .| |. .|
pdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1039-1221 1.1e-24 81.9 In-house 83-265 (274) alignment 
Range on Protein: 1039-1221
Range on HMM: 83-265/274.0
KDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKfGRYTVKTVSVEENL--DQFTDKQTAKVYTIEFHNnkvlmkvpfpVKILAFSGW
  | . || || . .. |.  | ..||  |.|||.|. .. . |.. .||.   . ||. .  .... ..    |... ..          ||   .. |
pntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis.erygdveikvekiverndysvrklvlkylerers..........vkhywytdW

PDHGAPAEPHTALDIIKYCESFK-------TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQ--LIYMLLC
||| .| ...| ||...  |. .       . |.|||| |.||||  .||. ...   ...| |.  .|  .|  | | |||..|  ||.  ||
PdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1037-1224 1.2e-24 81.6 In-house 96-285 (305) alignment 
Range on Protein: 1037-1224
Range on HMM: 96-285/305.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVK-TVSVEEN-LDQFTDKQTAKVYTIEFHNNKVLMKVpFPVKILAFS
| ..|   || |  . .   .  ||...| | .||.||.... | ...|     | .| .|     .|...  |||   ..  .    |.   |.   . 
plektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgeka.rkvthyhwi

GWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGI-QLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
 ||| | ||   . |.... . . |  . |||| |.||||..| ..| . || . | . |   ..  .|  |  ..||..| ...   | .
dwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqviln
subfamily_PTPN6_pd Subfamily PTPN6 1039-1220 1.5e-24 81.5 In-house 108-291 (306) alignment 
Range on Protein: 1039-1220
Range on HMM: 108-291/306.0
KDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMkFGRYTVKTVSVeENLDQFTDKQTaKVYTIefhnnkVLMKVPFPVKILAFSGWPD
..| . || |. .  . |.  . .  | |..||| |. .| . |. .|...|..||  ..|.... ..  .|  .         |    |  . |  |||
ettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvse.ksladYilRel.svskk......kkkkeerevfqyhfksWPd

HGAPAEPHTALDIIKYC----ESFK----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEV---SDMALVVDPVRACRYGAVQTEQQLIYMLL
|| |..| . || ..      |...      ..|||| |.|||||.. |   ..| .|. .    |.  .|  ||. | | ||||||  ..  
hgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvyk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1036-1228 1.9e-24 80.7 In-house 93-278 (515) alignment 
Range on Protein: 1036-1228
Range on HMM: 93-278/515.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQFtdKQTAKVytIefHNNKvlMKVpfpVKILAFSG
 |.| . . || .. ....  .| . . ||.   ||..|.       .||| . |..||.|   .    |.. .|  .  ....  ..    |    | .
gPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggi..krkltv..l..kgdd..srt...vtqfhfte

WPDHGAPAEPHTALDIIKYCES----FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
|||.|.| .  . | .||   .    ..  ...||| |||||| ...|.  .    . .. |.  .|  .|. |   |||..|  ..   .   |. 
WPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllw
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1037-1226 4.9e-24 80.0 In-house 97-280 (318) alignment 
Range on Protein: 1037-1226
Range on HMM: 97-280/318.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVeENLDQFTdkqtAKVYTIEfhNNKvlMKVPFPVKILAFSGW
|  .| | || |. |  . |.  | | .| | .|.. |.    || ...|. .|.  .   .|....     . ....  ...  ..    |.   .  |
PlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs..kgsrsygklvvelkee.velsdyv....lrefkvt..rte..eeesrqvrqyhytsW

PDHGAPAEPHTALDIIKYCESFK-----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
||.| |... . ||...  .. .     . ..|||| ||||||. .|..  ..   .... |.  .|  .|  |   ||||.| ...   ...||
pdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1037-1226 7e-24 79.1 In-house 98-281 (301) alignment 
Range on Protein: 1037-1226
Range on HMM: 98-281/301.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQFTDKQTAKVYTiefHNNKVLMKVpfpVKILAFSGW
| |.|.| || |.  |    .. |.|. |. |.||.||...... ... ||...|... |  |.. . |.| .|       .|.  .    |    .| |
Plkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtleved...stgkfatrt...vthyqysew

PDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
.|.| |       |...     .  ..|||| |.||. .... .|  .    .   ...  .  .|  |. .|||..|| .| |     |
tdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrl
WSN Domain of unknown function 46-112 7.6e-24 73.4 Pfam-A 2-68 (69) alignment 
Range on Protein: 46-112
Range on HMM: 2-68/69.0
TLSDSLPNFKSLARLANGISLEIGLIDGSIPSDDAIAELLHTGPVKLQEVINLNTTAIDTAITELEN
 |...| .....||..|||.|. |||.||||.||.|||||. |...|......... ... ...|..
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_PTPRG_pd Subfamily PTPRG 1037-1266 1.1e-23 78.3 In-house 99-326 (563) alignment 
Range on Protein: 1037-1266
Range on HMM: 99-326/563.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTevKGEMKFGRYTVKTVSVEENLdQFTdKQTAKVYTIEFHNNKVlMKVPFPVKILAFSGW
| ||| . || || | .. ..  . ...|.| .||  |. .   . ...|  .|. .. |      | ..| ..  .. ...|  ..    |.   .. |
plkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevla.lyt.vrtlviknlklkkkkq.cdteklvrqyhytkW

PDHGAPAEPHTALDIIKYCESFKTN----VLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEKAGV
||||.|  .   |  .|  .  . .    ..|||| |||||||.....  ..   .... ..  ..  .|| |   |||| | |..   . .|.. |   
PdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiaskete

LFWDNYNALHYYYDKLQTDYyEPYLKKDEKDPEL
|  .. ..|.     |. .| .  .. . ||  .
llaeqveelknctpyleqqy.kniiqfqpkdihi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1036-1230 5.8e-23 76.2 In-house 94-281 (315) alignment 
Range on Protein: 1036-1230
Range on HMM: 94-281/315.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENldqfTDKQTAKVYTIEFHNNKVlmkvpfpVKILAFSG
 |.| . . || |. ....  .. . . .|.   ||. |.  .    ..|| . |...|.| .    ||  . |. | . .. .        |    | .
gPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslead....tdgvarklvtrkseesrt.......vtqfqfte

WPDHGAPAEPHTALDIIKYCESF----KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEKA
|||.|.. .  . | .||   .     . ..||||| |||||| ...|.  ..   .... |.  .|  .|| |   ||||..  ..   . . |. . 
wPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrn
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1037-1226 6e-23 76.0 In-house 93-293 (301) alignment 
Range on Protein: 1037-1226
Range on HMM: 93-293/301.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSvEENLDQFTDKQTAkVYTIEFHN--------NKVLMKVPFPV
| | |   || .| ....  .  ... ||. ..|| .|...  . . .||  ||. |. | .. .|. .| . |   .  |        ..   | .  |
pmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvn.eqvyPdfvirqln.vkiqdgsnngyierkfkvksdksswdv

KILAFSGWPDHGAPAEPHTALDIIK-----YCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCIT
  |    ||..|   ||.| | .|           .  |.|||| .|.|.|. ...  |.  |  . | |.  |.  ||  . |||.| .| . .   |.
lqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

KAL
. |
myl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 981-1220 6.7e-23 75.7 In-house 36-261 (281) alignment 
Range on Protein: 981-1220
Range on HMM: 36-261/281.0
VDFNNDRFINANLMEIDGVKWIMTQGPMDGTEHVQEEKKNAEKRKSGEKVSKKpivPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVK
|. ...|..|   ..|  |.  .     . |.... .   .   | |  ...    |||.||  || || .  |  .  |||| |   .|||||.  . .
vnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqg...pkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnah

GEMKFGRYTVKTVSVEENLDQFTDKqtakvYTIEFHNNKVLMkvpfpvKILAFSGWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIK
  ..| ...|.      |    | .       . .  .  |.          .  |||   |      | |..   .  |  ..||| ||||.|||.|..
cclqfdklsvsyedstvnkslvttr.....lnlsyegetrli......thwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmave

YGIQL-CSKQEVSDMALVVDPVRA-CRYGAVQTEQQliYMLL
  .|   |.  . |.  .|  .|   |  .||| ||  |||.
ialqsihshftlpdikqivshlrvtgraasvqtlqq..ymli
PTPc_DSPc_SM00012 1128-1222 1.7e-22 74.9 In-house 2-103 (105) alignment 
Range on Protein: 1128-1222
Range on HMM: 2-103/105.0
VKILAFSGWPDHGAPAEPHTALDIIKYCESFKT------NVLVHCSVGVGRTGTLVAIKYGIQLCSKQ-EVSDMALVVDPVRACRYGAVQTEQQLIYMLL
|| . ..||||||.| |..  |.........|.      .|.|||| |||||||.||. . .| ..|. .  |.  .|  .|  | |.||||.| .... 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

CI
..
al
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1037-1229 2.1e-22 74.1 In-house 104-292 (305) alignment 
Range on Protein: 1037-1229
Range on HMM: 104-292/305.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKGE---MKFGrYTVKTVSVEENLDQFTDKQTAkVYTIEFHNNKVlMkvpfPVKILAF
|  .| ..|| |. . .   .  ||.  | |  |||.|. .  .||   .| |   |. ||    ... .. | . .  . .  ..  |     |. | .
pldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa.qgeklelksg.ivvenvsgskpmerdaeiqit.llnltysgdqk.m....svrhlqw

SGWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQ-LCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEK
. ||| | |    |.|...      |  ..|||| |.|||||.|||.| .. .. ....  |  .|  .|  |  ..|.. | ...   . . ..||
tewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
0036282 (Phosphotyrosine protein) phosphatases II 1039-1218 2.2e-22 75.0 In-house 27-162 (174) alignment 
Range on Protein: 1039-1218
Range on HMM: 27-162/174.0
KdtrekFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTevkgemkfgrytvktvsveenldqftdkqtakvytiefhnnkVLMKVPFPVKILAFSGWPD
.     || |. |..  .| .|.. ||.|  ||  |...                                                  .  . . .|||
a.....fwemlkelgittvvmlleekelglykcinywpe..........................................lredlerlgiqylylpwpD

HGAPAEPHtALDIIKYCESF-----KTNVLVHCSVGVGRTGTLVAIKYGIQLCSkQEVSDMALVVDPVRACRYGAVQTEQQLIYM
||.|  .   |...|..|..     .  |||||| ||||||||||. . ...   . . |   .|  .| .| |.|||..|... 
hgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfl
0043147 (Phosphotyrosine protein) phosphatases II 988-1219 3.8e-22 74.3 In-house 7-154 (172) alignment 
Range on Protein: 988-1219
Range on HMM: 7-154/172.0
FINANLMEIDGV--KWIMTQGPmdgtehvqeekknaekrksgekvskkpivpKKDTREKFWGMIEEYRTGVVAQLCQFkedgenkcaeyystevkgemkf
.|||.....  .  ..|.||||                                 | ..|| |. |.  ...  |...                      
yinasyldlyyipdrfiatqgp..............................lrntladfwrmlkelgithivnltel......................

grytvktvsveenldqftdkqtakvytiefhnNKVLMKVPFPVKILAFSGWPDHGAPaEPHTALDIIKYCES-----FKTNVLVHCSVGVGRTGTLVAIK
                                 .   ..   .  . . .|||||.|  .   |........      .  |||||| ||||||||||. 
................................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

YGIqlcskQ-EvsDMALVVDPVRACRYGAVQTEQQLIYML
. .     .    ..  .|. ||..| ||||...|... .
lml.....lgl..sleeavalvrekRpgavqnpsqyrfly
subfamily_PTPRK_pd Subfamily PTPRK 1036-1227 4.5e-22 73.3 In-house 93-278 (314) alignment 
Range on Protein: 1036-1227
Range on HMM: 93-278/314.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkGEMkFGRYTVKTVSVEENLDQFtdkqtAKVYTIEFhnNKVLMKVPFPVKILAFSG
 |...| . || .. ....  .  | ...| |  || .|.  .  .|. .|   |. |..| . .       ......|    .  ..    |. . | |
gPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tev.ygdikvelvetellaelv.....vrifrvek..largqeeirevrqfqflg

WPDHGAPAEPHTALDIIKYCESFKT----NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALM
||||. | . .. |....  .. .     ...|||| | ||||| .||.  ...  ...| |.  .|  .|. .   |.||.| ...   |  | .
WpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileacl
0049260 (Phosphotyrosine protein) phosphatases II 1037-1218 5.1e-22 73.6 In-house 17-142 (152) alignment 
Range on Protein: 1037-1218
Range on HMM: 17-142/152.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYstevkgemkfgrytvktvsveenldqftdkqtakvytiefhnnkvlmkvpfpvkILAFSGW
|   | ..|| |. |.  ...  |... |.|. ||..|.                                                         .  |
pgpntladfwrmlkelgittivmltellelgklkceqyi......................................................qylhlpw

PDHGAPAEPHTALDIIKY----CESFKTNVLVHCSVGVGRTGTLVAIKYGIqlcskqEVSDMALVVDPVRACRYGAVQTEQQLIYM
||||.|  .   |....     ... . .|||||| ||||||||||. . .         ..  .|. ||..| |||....||.. 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
0046846 (Phosphotyrosine protein) phosphatases II 1036-1221 6.3e-22 73.6 In-house 30-168 (176) alignment 
Range on Protein: 1036-1221
Range on HMM: 30-168/176.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMkfgrytvktvsveenldqftdkqtakvytiefhnnkvlmkvpfpvkILAFSG
 |  .| ..|. |. |.. ..|  |.. .| |  ||. |.. . | ..                                                 . .
gplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............................................qylhlp

WPDHGAPAEpHTALDIIKYCESFK---TNVLVHCSVGVGRTGTLVAIKygiqLCSKQEVSDMALVVDPVRACRY-GAVQTEQQLIYMLLC
|||||.|      |.........     .|||||| |.||||||||.     |. ..   ..  ... ||..|  |||||..|. .   .
wpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyrflyef
subfamily_PTPN23_pd Subfamily PTPN23 1037-1227 7.6e-22 72.4 In-house 91-284 (288) alignment 
Range on Protein: 1037-1227
Range on HMM: 91-284/288.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEEnldqfTDKQTAKVYTIEFHNNKVLMKVpfpvKILAFSGW
|.. |   || |. | .. |.  | . .| |..|...|. ..    .||| ..|   ||.|     |..   .| ..|.....   .|    . | .  |
PlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre.....tethvervlkletldadavksv....shlqltsW

PDHGAPAEPHTALDIIKYCES--------FKTNVLVHCSVGVGRTGTLVAIKYGIQLC-SKQEVSDMALVVDPVRACRYGAVQTEQQLIYML---LCITK
|..|.|| |.| |....  ||         || ..|||| ||||||..  .   ..    .. . |.  ||  .|. |   ||...||  ..   |. ..
pelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

ALM
  .
rvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1037-1224 8.1e-22 72.5 In-house 83-268 (285) alignment 
Range on Protein: 1037-1224
Range on HMM: 83-268/285.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQFTDKQTAKVYtiefhNNKVLMKVPFPVKILAFSGW
|  .|   || || . .   |  || . | | .||| ||  ..   .|||.| .    ..|.    |  ..  |      | .     |. .. .    |
plpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvi.....ntedasseplymnhvqvpww

PDHGAPAEPHTALDIIKYCES---FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
||. || . .  ... |. .     .. . |||| ||||| |.| | |      ..   .|  .|  .|| |. |||.  |.... . . .
pdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1037-1249 1.7e-21 71.9 In-house 112-311 (319) alignment 
Range on Protein: 1037-1249
Range on HMM: 112-311/319.0
PKKDTREKFWGMIEEYRTGVVAQLCqfkedgENKCAEYYSTevKGEMKFGRYTVKTVSVEENLDqftdkqtAKVYTIEFHNnKVLMKVPFPVKILAFSGW
|...| . || || ||..  .  |       ..||..|.    |...| .|. ||  ||||  .         |  ||  . .  .|    ..   | ||
PldntladfWrmiweyncstivllt......kdkcsqywpl..kivikeerfkvkvdsveetae.......yvvrdielse.dgkekdirkitqfhflGw

PDHGAPAEPHTALDIIKY------CESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK-ALMEK
||.| |  |   . ..|        |  ..|..|||| ||||||. ....  ..   ...  |.  .|  .|  |   ||   |  ..   . .  |. .
pdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh

AGVLFWDnynaLHYYYDKLQ
. | . |    .  |...| 
sdvampd....fpayleels
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1037-1251 1.9e-21 71.8 In-house 76-277 (284) alignment 
Range on Protein: 1037-1251
Range on HMM: 76-277/284.0
PKKDTREKFWGMIEEYRTGVVAQLCqfkedgENKCAEYYSTevKGEMKFGRYTVKTVSVEENLDqftdkqtAKVYTIEFHNnKVLMKVPFPVKILAFSGW
|...| . || || ||..  .  |       ..||..|.    |...| .|. ||  ||||  .         |  ||  . .  .|    ..   | ||
PldntladfWrmiweyncstivllt......kdkcsqywpl..kivikeerfkvkvdsveesee.......yvvrdielse.dgkekdirkirqfhflgw

PDHGAPAEPHTALDIIKY------CESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK-ALMEK
||.| |  |   . ..|        |  ..|..|||| ||||||. ....  ..   ...  |.  .|  .|  |   ||   |  ..   . .  |. .
pdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfgh

AGVLFWDnynaLHYYYDKLQTD
. | . |    .  |...| ..
sdvalpd....fpayleelsnk
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 988-1223 2.3e-21 71.0 In-house 21-218 (255) alignment 
Range on Protein: 988-1223
Range on HMM: 21-218/255.0
FinanlmeidgvkwimtqgpmdgTEHVQEEKKNaeKRKSGEKVskkpivpkkdTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGR
                       ||||. ||..  |||. . .          | .||. .|   .| ||. || |.|.| .|| .|. .|  . .|.  
c......................tehvkPekdk..krknlysl..........tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklklad

YTVKTVSveenldqftDKQTAKVYTIEFHNNKVLMKVPFPVKILAFSGWPDHGAPAEPHTALDIIKYCESFkTNVLVHCSVGVGRTGTLVAIKYGIQ--L
 .| |             .   . |.|   .    |    ||   . ||... || ...  | |.|        |.|||| |.||. ..| . .  |  .
vnvtttk.........ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmi

C--SKQEVS--DMALVVDPVRACRYGAVQTEQQLIYMLLCIT
    . |    |   ... .|  | .|..|  || . .| . 
rsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1037-1230 5.1e-21 69.7 In-house 90-280 (312) alignment 
Range on Protein: 1037-1230
Range on HMM: 90-280/312.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYStEVKGEMKFGRYTVKTVSVEE--NLDQFTDKQTAKVYTIEFHNNKVLMKVpfpvKILAFS
| ..|  .|| .     .  .  || | ||| .|||.| | .. | ...  . | | .. |     .  || | .|  .  .      |.    .   ..
plentcthfwqlalslgstsiillcgfvedgsekcakyis.divgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl....nhyqwa

GWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGI---QLCSKQEVSDMALVvdpVRACRYGAVQTEQQLIYMLLCITKALMEKA
 ||||| |    ||| ..      |  |. ||| ||||||||. |.  |   .   ||.| |. ..   .|  |  .|..  | .| | |. . |. |.
swpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_Ptp69D_pd Subfamily Ptp69D 1037-1220 1.1e-20 69.1 In-house 99-280 (307) alignment 
Range on Protein: 1037-1220
Range on HMM: 99-280/307.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkGEMKFGRYTVKTVSVEEnLDQFTDKQtakVYTIEFHNNKVLMKVPFPVKILAFSGW
|   | . || || |    ..  | . .|  ..||| |.. |   |...|   ||.|| |.  .... ..   ..  . ...   ..    |    . ||
PveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseek.hsdyiiRe...ldvskkkeesgevedsrkvvqyhytgW

PDHGAPAEPHTALDIIKYCESF----KTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLL
.|  .|  ... |..|.  ..     .. ..|||| ||||.|..||..  .| . . .  |.  .|  .|  |   ||  .| ...  
kDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyr
subfamily_PTPN14_pd Subfamily PTPN14 1037-1219 1.2e-20 68.7 In-house 101-289 (300) alignment 
Range on Protein: 1037-1219
Range on HMM: 101-289/300.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTE--VKGEMKFGRYTVKTvsveenldQFTDkQTAKVYTIEFHNNKVLMKVPFPVKILAFS
| . | ..|| |. |  . ....| . .||| .|. .|.  .   | ...||.. | |        .|.. .. .| |. .. . .. |    | .| . 
PleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt........kfse.dsdsvittglklkhlpskeertvwhlqyt

GWPDHGAPAEPHTALDIIKYCESFKT-------------NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
 ||||| | .... |. ..  .| .               |||||| |||||| |.     |.   ..|. |.  |.. .|  |   |||  |  .. 
DWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvY
subfamily_hpo-7_pd Subfamily hpo-7 988-1228 1.9e-20 67.9 In-house 24-229 (263) alignment 
Range on Protein: 988-1228
Range on HMM: 24-229/263.0
FinanlmeidgvkwimtqgpmdgTEHVQEEKKNaeKRKSGEKVskkpivpKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGR
                       |||.. || .  |||. . .         .| .||. .|.  .| ||. || |.|.| .|| .|. .|  . .|.  
c......................tehfkPekdk..krknlysl.......lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklan

YTVKTVSVEEnlDQFtdKQTaKVYTIEFHNNKVLMKvpfpVKILAFSGWPDHGAPAEPHTALDIIKYCESFkTNVLVHCSVGVGRTGTLVAIKYGIQ--L
 .| |  | .  |    ..| .. .  . . | . .    ||   . ||... .| ...  | |.|       .. |||| |.||.   . .    |  .
vnvcttkvqs..dvl..lkt.lellstlgeKkktht....vkhysykgWiekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmi

C--SKQEVS--DMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
    . .    |   ... .|  | .|..|  || . .| . . ...
rsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvln
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1036-1228 2.3e-20 67.9 In-house 99-286 (297) alignment 
Range on Protein: 1036-1228
Range on HMM: 99-286/297.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGEnKCAEYYSTevKGEMKFGRYTVKTVSVEENLDqFTDKqtakvyTIEFHNNKVlmKVPFPVKILAFSG
 |.|.| . || |. .... ... | . .|  . ||| |.|   || ..||  .|.. ||.|    | ..      ..|  ..|   |.   ||   |  
mPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd..kgvttfGdvsvvllsvsereG.fikr......elevtkgka..karrvvkqyqfve

WPDHGAPA--EPHTALDIIKYC-ESFKT----NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALME
|||.  .   . .. |..|.   ..|..     .||||. |||||| |..|.  .    ...  |.  .|  .|  |   |||..|  ..   . .||. 
WPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0051082 (Phosphotyrosine protein) phosphatases II 1043-1222 2.2e-19 65.0 In-house 23-149 (151) alignment 
Range on Protein: 1043-1222
Range on HMM: 23-149/151.0
EKFWGMIEEYRTGVVAQLCQFKEDGenKCAEYYSTEVkgemkfgrytvktvsveenldqftdkqtakvytiefhnnkvlmkvpFPVKILAFSGWPDHGAP
. |. ...|.   ..  |.. .| |  .|.||.  .                                               . |. . . .|||.| |
adflellkelgiktivnlrseeerg..ycpeylpelg..............................................ievlhipildwpdpglp

AEPHTALDIIKYCESF-KTNVLVHCSVGVGRTGTLVAIKYGIqLCskqevSDMALVVDPVRACRYGAVQTEQQLIYMLLCI
  ....|........  . .|||||| |.||||||||.   . |       ... ... .|..| |.||..|| .. |...
lsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_PTPN9_pd Subfamily PTPN9 1037-1222 3.5e-19 64.0 In-house 93-286 (297) alignment 
Range on Protein: 1037-1222
Range on HMM: 93-286/297.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQfTdKQTAKVYTIEFHNNKVLMKvpfpvkiLAFSGW
| | | . || |. | .. |.    .. | |  ||..|. .| .  ..|| ..|..|.|||. |  . ... ... .. .... ..          | .|
plkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedy.k.vrvleiknvkteesrkvth.......fqflsW

PDHGAPAEPHTALDIIKYCESFK-----------------TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
||.| | . .. ||...   . .                   ..|||| |.|||||.... . ..   .... |.  .|  .|. |  ..||..|  .  
PdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcy

LCI
|..
lav
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1037-1220 4.2e-19 63.5 In-house 83-258 (283) alignment 
Range on Protein: 1037-1220
Range on HMM: 83-258/283.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkGEMKFGRYTVkTVSVEENLDQFTDKQTAKVYTIEfHNNKVLmkvpfpVKILAFSGW
| ..|.  || |. . .   .  | ...|| . ||. |.  .  | ...| .|| |.  |   . |. |.    .     ....|      .    . .|
PldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkr..GsedyGeftv.tlrkettsnsfiikelllrvnss.akstll......lahyqvidW

PDHGAPAEPHTA--LDIIK--YCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQliYMLL
 . |  |   .   .. ..    || |. ..|||| |.|||....|.   ..    . | |.  ||  .|  | .|||| .|  |.|.
leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldq..yklv
subfamily_PTPN1_pd Subfamily PTPN1 1037-1224 1e-18 62.1 In-house 79-269 (290) alignment 
Range on Protein: 1037-1224
Range on HMM: 79-269/290.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVK-GEMKFG--RYTVKTVSVEEnLDQFTdKQTAKVYTIEFHNNKVLMKvpfpvkiLAF
|  .| . || |. | ..  |  | .. | ...|||.|. .. .  |...   ...|| .| |.  ...|  .. ..  .. .. .....         .
PlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseer.ksyyt.vrllelenlktqetreilh.......fhy

SGWPDHGAPAEPHTALDIIKYCE---SFKT---NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEV---SDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
  ||| | |  | . |. .  .    |...    ...||| |.||.||.. .   . |  |..     |.  |.  .|  | | .|| .|| .  | | .
ttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
0049772 (Phosphotyrosine protein) phosphatases II 966-1222 8e-18 60.7 In-house 51-276 (314) alignment 
Range on Protein: 966-1222
Range on HMM: 51-276/314.0
RKQMFICYPqTMPKL--VDFNNDRFINANLMEIDgVKWIMTQGpmdgtehvqeekknaekrksgekvskkpivPKKDTREKF----------WGMI--EE
| . ..... .  .|  .....  .|||. .     |.| |||                              |.. | . |          | |.  ..
ryldilpad.nrvilpglpvsgsdyinasyvdgf.lkfIatqg..............................pleitvvdfreepvlyyngwrmvlrgd

YRTGVVAQ---------------------LCQFKEDGenkcaeyystevkgemkfgrytvkTVSVEENLDQFTdkqtakvytiefhnnKVLMKVPFP---
... ..                       |... . |                           ....|...                ..|   ...   
lnvrdivmsrdevladelsrLdaAlgKtpllildgng........................neptaadlellk...............eelydpelferl

-VKILAFsGWPDHGAPaEPHTALDIIKYCES--FKTNVLVHCSVGVGRTGTLVAIKYgiqLCSKQEVsDMALVVDPVRACRY-----GAVQTEQQLIYML
 .| | .  .||..||  .   .......|.   ...|||||. |.|||||.|.. |   |.... | ... ... ||..|.     |.... .|....|
gikylri.pvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfieqleqyefil

LCI
 ..
eal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1037-1221 9.4e-18 59.2 In-house 100-276 (315) alignment 
Range on Protein: 1037-1221
Range on HMM: 100-276/315.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkgEMKFGRYTVKTVSvEENLDQFTdkqtAKVYTIEFHNNkVLmKvpfpVKILAFSGW
|.  . . || .. |.  | .  | .  |. ..|. .|.  .   .. .|..||  .| ||  ...|     . ... | .| .  .    |  | .. |
pnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrks.eevnteyt....vrtlsvvfgdn.ir.e....vvqlhytsw

PDHGAPAEPHTALDIIKYCESFKTN----VLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQ--LIYMLLC
|| | |.   . ...|.    ..||    ..|||| |||||||.....  ..    ... |.  ..  ||. | ..||. .|  .||  | 
pdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydall
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 991-1219 1.2e-17 58.6 In-house 45-270 (287) alignment 
Range on Protein: 991-1219
Range on HMM: 45-270/287.0
ANLMEIDGVKWIMTQGPMDGTEHVQEEKKNAEKRKSGEKVSKKPIvpkKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKGEMKFGRYTV
|... ||  . .... .  |....  .   . ...    ... ||     |  .|| .. | |. .|. . .  |.. .|| .|.    .  |. | |.|
advlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPi...aatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysv

KTVSVEENLDQFTdKQTAKVYTIEFHNNKVlmkvpfpVKILAFSGWPDHGAPAE----PHTALDIIKYCESFK-----TNVLVHCSVGVGRTGTLVAIKY
  .. .    ...  .. ..  .| .. .|       || | .  |||....         .||. .. |  .       ..||..||.||.|.|.|.  
vlldydikePeyg.vralrlidletrearv.......vkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlv

GIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
 ..   .    |.| ||  .|  | . ||.  || .. 
lvsrledlGrvdvaavvirlreyraalvqavvqlrlly
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1035-1228 3.2e-17 57.7 In-house 97-290 (325) alignment 
Range on Protein: 1035-1228
Range on HMM: 97-290/325.0
IVPKKDTREKFWGMIEEYRTGVVAQLCQFkEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEEnldqFTDKqTAKVYTIEFHNnkvlMKVPFPVKILAFS
 .|. .| . .| .. ..|. ||  | .. . |...|| |.  |.    .||   || ...||    ..|    .|. .   .          || . . 
qaPltatindlWrlvldWrcsvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtiee....isdy.vhrvldvkqvk....kGetrsvkqfqlq

GWPDHGAPAEPHTALDIIKYC----ESFKT------NVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
.|.| | .  | | . |..      |  ..       .||||| ||||||.....   ..   ..   |.  .|  .|. |   |.|  | | .  ....
swddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve

ALME
|.| 
ayms
subfamily_PTPRN_pd Subfamily PTPRN 1037-1224 6.5e-17 56.2 In-house 108-290 (297) alignment 
Range on Protein: 1037-1224
Range on HMM: 108-290/297.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvkGEMKFGRYTVKTVSVEENLDQFTDKqtaKVYTIEFHNNKVLMkvpfpVKILAFSGW
|  .|  .|| |. |  . |. .|.. .|.| ..|..|.  |  |.  .. | |. ||     |..  .     |  ......        |  . |  |
plastvadfwqmvweqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcddylvr...sfylknlqtsetrt.....vtqfhflsw

PDHGAPAEPHTALDII-KYCESFK---TNVLVHCSVGVGRTGTLVAIKYGIQLCSK-QEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
|..|.||.... |.   |   |..   . ..|||| |.||||. ..|   ..   |     |.|  .. .|  | | |.|..|. ..| ....
peegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0044763 (Phosphotyrosine protein) phosphatases II 1043-1222 8.9e-17 56.7 In-house 38-167 (178) alignment 
Range on Protein: 1043-1222
Range on HMM: 38-167/178.0
EKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgemkfgrytvktvsveenldqftdkqtakvytiefhnnkvlmkvpfpVKILAFsGWPDHGAP
.... .. |.  ...  |.. .| | .|| .|. .|                                                 .. | . ..||||.|
addlellkelgithivnlteelelgflkcdpywpeeag...............................................iqylhi.pipDhgvp

AEPHTALDIIKYCE----SFKTNVLVHCSVGVGRTGTLVAIKYGIQLcskqEVsDMALVVDPVRACRYgAVQTEQQLIYMLLCI
  .   |......|    . . .|||||| ||||.|||||. . ..|     . ..  ... ||..|  .|... || ..... 
dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpnpgqlrqLyefe
0048179 (Phosphotyrosine protein) phosphatases II 1124-1219 1.2e-16 56.2 In-house 45-138 (144) alignment 
Range on Protein: 1124-1219
Range on HMM: 45-138/144.0
VPFPVKILAFSGWPDHGAPAEPHTALDIIKYCESF---KTNVLVHCSVGVGRTGTLVAIKygiqLCSKQEvSDMALVVDPVRACRYGAVQTEQQLIYML
. ...  . . .|||||.|  ..  |......|..   . .|||||| ||||||||||.     |. |.   ..  ... ||..|.|||....||...|
leregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrfLl
0048076 (Phosphotyrosine protein) phosphatases II 1130-1222 3.2e-16 54.8 In-house 49-139 (145) alignment 
Range on Protein: 1130-1222
Range on HMM: 49-139/145.0
ILAFSGWPDHGAPAEPHTALDIIKYCESF---KTNVLVHCSVGVGRTGTLVAIKygiqLCSKQEvSDMALVVDPVRACRYGAVQTEQQLIYMLLCI
 . . .|||||.|  . . |......|..   . .|||||| ||||||||||.     |. ..   ..  ... ||..| |||....||.......
qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealelvrsqrpgavpnpgqlrflyefe
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1037-1219 2.7e-14 48.0 In-house 53-232 (237) alignment 
Range on Protein: 1037-1219
Range on HMM: 53-232/237.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEvKGEMKFGRYTVktvSVEENlDQFTDKqTAKVYTIEFhnNKVLMKVPFpVKILAFSGW
| . . . || |. . .  |.  |  . |  | || .|.    .    .| .||   |.  . ..|.|  | . ...    .  | .| . ..   |. |
plesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaaygvltv...slkkk.eefsdy.tvrslllsk..rltlkevrl.ihqyqftsw

PDHGAPAEPHTALD----IIKYCES--FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYML
||.| | .  . |     ||.  .     .  ..||| |||||| .. |   .. . ...| |.   |  .   |   .||..| ... 
pdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfih
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1033-1226 2.8e-14 47.4 In-house 95-279 (439) alignment 
Range on Protein: 1033-1226
Range on HMM: 95-279/439.0
KPIVPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGEnkcaeYYSTEvkGEMKFGRYTVKtVSVEENLDQFTDKqTAKVYtiefhNNKVLMKVPFPVKILA
.  .|||.| ..|| .. | .|  . .|... |        |. ..  .|. .|  .|. |  . .| ... .   ||.     |..   .    |  . 
atqgpkkettddfwrlviekktvtivmltnlvesyk.....ywpsd..aevcygdiavr.vdrnielpnyvir.gfkvf.....nerdttekertvlqfh

FSGWPDHGAPAEPHTALDIIKYCESFK-----TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKAL
.  |||.  ||.    || ..  .| .       |.|||| |||||||..|.   ..    ..  |.  .|  .|  |   ||.  | ...  .. . .
yiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_CG7180_pd Subfamily CG7180 1037-1227 4.6e-13 43.5 In-house 93-291 (296) alignment 
Range on Protein: 1037-1227
Range on HMM: 93-291/296.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGEnKCAEYYSTEVkgEMKFGRYTVKTVSVEE--NLDQFTDKQTAKVYTIEFHNNKVLMKVPFpVKILAFS
|||.| ..|| .. .  .  |  |..  .  . .. .|.  .   . ..|   |..|....  || . | | | |. ..  ....| ...   || . . 
pkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRi.vklfqlt

GWPD-HGAPAEPHTALDIIKYCESFKTNV---------LVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITK
 |.  .  |    . .....  .... .|         .|..| |..|.|  .||   ..| .|.|  |.   |  .|  | . |.. ..  |.   . .
eWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlle

ALM
|..
avl
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1038-1218 5.4e-12 39.9 In-house 103-282 (310) alignment 
Range on Protein: 1038-1218
Range on HMM: 103-282/310.0
KKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEmKFGRYTVktVSVEENLDQFTDKQTAKVYT---IEFHNNKVLMKvPFPVKILAFS
 . |   || || . |.  .  ||.  |.|  ||  |. .    |  .|   |    . |  ..|   . |  .    .   ..   .|  . |... . 
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvte.tygcirv..tnlsesseefeicnlavtfvpdnvpvdeqpanlk.elrvslikwp

GWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYM
 ||| | | |   ..     ..  .  ..|||| |..|....||.|. |.   . .  |.  |.  ..  |.  .||| | ...
nwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqylii
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1037-1144 1.4e-11 38.8 In-house 84-182 (297) alignment 
Range on Protein: 1037-1144
Range on HMM: 84-182/297.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSveENLDQFTDKQTAKVyTIEFHNNKVLmkvpfpVKILAFSGW
| ..| . || .. |   .|.. .....||| .||| |.   |.. .| | . |. .|  .  |.|   . ... .. . ...        |.   | .|
plsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvvefls..stsdefdrviltel.qliyrsesrv......vrhvqflsw

PDHGAPAE
|||| |..
pdhGvpsd
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1043-1223 8.3e-11 36.5 In-house 65-237 (239) alignment 
Range on Protein: 1043-1223
Range on HMM: 65-237/239.0
EKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgemKFGRYTVKTVSVeenlDQFTDKQTaKVytieFHNNKVLMKVPFPVKILAFSGWPDHGAP
  || |. . |  |.  |  . |  ..|| .|.        |.    |         . |.|    .     |  ..|       |    |. |||.| |
gdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kycnlrvtlrkt....evfadyii.rt....fvmsqvgqteeryvyqyhftvwpdkgvp

AEPHTALDI----IKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCIT
    . | .     |         ..||| ||||||... |   .. . ||.  |.   |  .|  |   ||| .| ... |.. 
qyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1036-1229 1.4e-10 35.1 In-house 95-239 (392) alignment 
Range on Protein: 1036-1229
Range on HMM: 95-239/392.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGenkcaeyystevkgemkfgrytvktvsveenldqftdkqtakvytiefhnnkvlmK--VPFPVKILAF
 |.  . . || |. . ..  .| . ..||                                                         |      |    |
gpnaaslddfwrmvfqenvttiamvtklkegd.......................................................kgddartvaqfhf

SGWPDHGAPAEPHTALDIIKYCE----SFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKALMEK
. |||.. |    . | .||  .    ..   ...||| |||||| ...|   .  . |  . |.  .|  .|  |   |||..|  ..  .. . |. .
tewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwr
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1043-1222 1.4e-10 35.7 In-house 66-237 (239) alignment 
Range on Protein: 1043-1222
Range on HMM: 66-237/239.0
EKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKgemKFGRYTVKTVSVeenlDQFTDKQTaKVytieFHNNKVLMKVPFPVKILAFSGWPDHGAP
  || |. . |  |.  |  . |  ..|| .|.        |.    |         . |.|    .     |  ..|       |    |. |||.| |
gdfwrmmwqerrcvivmltglieghkkkchqywpdsts...kycnlrvtlrkt....evfadyii.rt....fvmsqvgqteeryvyqyhftvwpdkgvp

AEPHTALDI----IKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCI
    . | .     |         ..||| ||||||... |   .. . ||.  |.   |  .|  |   ||| .| ... |..
qyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1039-1218 2.2e-09 31.7 In-house 82-251 (267) alignment 
Range on Protein: 1039-1218
Range on HMM: 82-251/267.0
KDTREKFWGMIEEYRTGVVAQLCQFkedGENKCAEYYSTEVKGEMKFGRYTVktvsvEENLDQFTDKQTAKVYTIEFHNNKVlmkvpFPVKILAFSGWPD
| |  .|. .| ...  |.  | .    ....   ..  ..    |.   ||     | .|..  .     .  ..|.|.       . | .  .  |  
kntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltv.....ehslekeendyqiitlelkfknesa.....hnvtlyyykkwni

---HGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYM
        .|  ..   .  |     ..|.|| ||||.||.. |.  ..   ...|||.   .  .|  | | |.| .. ||.
ntnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyi
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1037-1181 6.4e-09 30.0 In-house 112-284 (350) alignment 
Range on Protein: 1037-1181
Range on HMM: 112-284/350.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTE-VKG-EMKFGRYTVKTVSVEENLDQFTDKQTAKV------YTIEFHNNKVLMKV----
| . | ..|. .| .    |.  | .  | . .|| .|.    ...  .|.     .......     .| ..  .         . ..|. |...    
PlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaa

--PFPVKILAFSGWPDHGAPAEPHTALDIIK---------YCESF-----KTNVLVHCSVGVGRTGTLVAIKY
  |. |  | .  |.| .   .|.  | ...         ..||.      . .||||| |||||||||.. .
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDs
0038934 (Phosphotyrosine protein) phosphatases II 1135-1215 1.6e-08 30.0 In-house 86-166 (194) alignment 
Range on Protein: 1135-1215
Range on HMM: 86-166/194.0
GWPDHGAPAEPHTALDIIKYCESFKTN-----VLVHCSVGVGRTGTLVAIKYGIQLCSkqevsDMALVVDPVRACRYGAVQTEQQL
 .||.|..    . |.... .. |  .     |.|||  |.||||||||      |.      ..   .. .| .| ||... ..|
pfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgm.....saeeAialfrekRpgaipnqdyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1129-1233 2.4e-08 27.8 In-house 92-201 (440) alignment 
Range on Protein: 1129-1233
Range on HMM: 92-201/440.0
KILAFSGWPDHGAPAEPHTALDIIKYCES-----FKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCIT
|   . ||||.| |      | .|.  .       .  .|||||.|.|||| ..|.   .. . . .  |.  ... .|  |   ||| .|  ..  .. 
kqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvheavl

KALMEKAGVL
..|.    ..
egllcgdtli
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1160-1220 4.2e-08 27.4 In-house 229-289 (297) alignment 
Range on Protein: 1160-1220
Range on HMM: 229-289/297.0
TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLL
. .||||| ||||.| .|  .  ..   |. . |.| ..  .|  |   ||| .|  ..  
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyd
TMEM154 TMEM154 protein family 802-875 5.5e-08 24.3 Pfam-A 21-94 (146) alignment 
Range on Protein: 802-875
Range on HMM: 21-94/146.0
PQPPSSAASLTPAPsaaQNAPSIAPSTTEASEEESS--GSMLWIIIGAVVV-VLIILVILLYLKCMRKEPKEDPTVS
  ..|. || |      . . .. .. .| ||....    .| ||| .||  .|...|..|  |. ||  |...|  
tvtastlasvtdpe...tlsanvnleegelseksadqaelvlmiiiPsvvLillllvvvilvikkkrkrrKqeetse
subfamily_CG42327_pd Subfamily CG42327 1160-1217 6.1e-08 26.7 In-house 248-306 (319) alignment 
Range on Protein: 1160-1217
Range on HMM: 248-306/319.0
TNVLVHCSVGVGRTGTLVAIKYGIQLCSKQ-EVSDMALVVDPVRACRYGAVQTEQQLIY
  . |||| ||||||...|    |.   .  .  |.  .|  ||  |  ||.| .|  .
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef
subfamily_PTPDC1_pd Subfamily PTPDC1 1134-1215 7.8e-08 27.0 In-house 88-165 (182) alignment 
Range on Protein: 1134-1215
Range on HMM: 88-165/182.0
SGWPDHGAPAePHTALDIIKYCESF--KTNVLVHCSVGVGRTGTLVAIkygIQLCSKQEVSDMAlvVDPVRACRYGAVQTEQQL
 ||.|.|...  ...|||.|  ..   . .| |||  | |||| |.|    . . .|.  .. |  .. ||. |  ..|| .|.
fgwkDygvas.leriLdivkvvafalqegkvavhChaGlGrtGvliac...ylvyakrltaeka..iklvrskrpksiqtreqv
DUF3753 Protein of unknown function (DUF3753) 831-864 3.8e-07 16.4 Pfam-A 39-72 (72) alignment 
Range on Protein: 831-864
Range on HMM: 39-72/72.0
ASEEESSGSMLWIIIGAVVVVLIILVILLYLKCM
...|.|| .. ..||  ..||...|...|||| .
kkkensssniiiliiliiivvivvllvflyLklv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1037-1213 4.5e-07 24.2 In-house 12-190 (198) alignment 
Range on Protein: 1037-1213
Range on HMM: 12-190/198.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVeenldqfTDKQTAKVYTIEFHNNKVLMKVPFPVKILAFSGW
| ..|   || |. |  .| .  . . . . |   . |..|   |  |.|  .| | ..       | |    . .. . ||         .    |. |
plretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.......ttkpdytitaliltnnttappstreishyqftsw

PDHGAPAEPHT------ALDII-KYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQL--CSKQEVSDMALVVDPVRACRYGAVQTEQ
 .. .|           . ..  || .   . |.|||| | | || .||.  |..    ||  | |.  |   .| .| | . . |
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1037-1213 5.1e-07 24.0 In-house 13-191 (199) alignment 
Range on Protein: 1037-1213
Range on HMM: 13-191/199.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVeenldqfTDKQTAKVYTIEFHNNKVLMKVPFPVKILAFSGW
| ..|   || |. |  .| .  . . . . |   . |..|   |  |.|  .| | ..       | |    . .. . ||         .    |. |
plretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttkti.......ttkpdytitaliltnnttappstreishyqftsw

PDHGAPAEPHT------ALDII-KYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQL--CSKQEVSDMALVVDPVRACRYGAVQTEQ
 .. .|           . ..  || .   . |.|||| | | || .||.  |..    ||  | |.  |   .| .| | . . |
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq
subfamily_CDC14_pd Subfamily CDC14 1150-1215 5.3e-07 23.8 In-house 254-314 (328) alignment 
Range on Protein: 1150-1215
Range on HMM: 254-314/328.0
DIIKYCESFKTNVLVHCSVGVGRTGTLVAIkYgiqLCSKQEVSdMALVVDPVRACRYGAVQTEQQL
  .. .|. . .. |||  |.||||||.|  |   |  . ...  | ..  .| || | | . || 
kfleiaekaeGaiavhCkaGLGrtGtLiac.y...lmkhyrft.aaeaiawlricrPGsvigpqqk
PTPc_motif_SM00404 1148-1179 5.5e-07 24.6 In-house 69-100 (140) alignment 
Range on Protein: 1148-1179
Range on HMM: 69-100/140.0
ALDIIKYCESFKTNVLVHCSVGVGRTGTLVAI
.||.|. .|. ...||||| .|| |..||.. 
vldfienaekkggkvlVHCqaGvSRSatliia
SSFA2_C Sperm-specific antigen 2 C-terminus 582-681 6e-07 15.7 Pfam-A 61-162 (179) alignment 
Range on Protein: 582-681
Range on HMM: 61-162/179.0
RQHLEILQKSGQSMKSADGREALALKTSFTDSQNTVKDLAL-AVRGLTQINKLMQ-IRGSLDALKGDFTEIQEAAAKALSSENVAEINKLNGLRDALKKT
|. |..|... | .      .   | ..   .|..||.|   .|. |  . . ..  |  |  |   ..  |    . || |.  |...|..||.|... 
rrvLkdlrdtlqnlsqysvvrGqdlaaarystqrsvkpLyectvqElevvrrslnlFreqledlElallrqqalvyqdlseEeReEaeqLqtLRkavRqe

LD
|.
lq
subfamily_CG42327_pd Subfamily CG42327 1036-1102 7e-07 23.2 In-house 79-146 (319) alignment 
Range on Protein: 1036-1102
Range on HMM: 79-146/319.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVK--GEMKFGRYTVkTVSVEENLDQF
|. .|.  .|| .. | .. |. ||..  | | ..||||. |.    ..  .| . | |.   |  |..
vsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyGdilv.tlkgrevkdry
subfamily_ptpA1_pd Subfamily ptpA1 1037-1178 7.1e-07 23.3 In-house 97-248 (418) alignment 
Range on Protein: 1037-1178
Range on HMM: 97-248/418.0
PKKDTREKFWGMIEEYRTGVVAQLCQFKEDGENKCAEYYSTEVKGEmKFGRY-----TVKTVSVEeNLDQFTDKQtAKVYTiefHNNKV-LMKVPFPVKI
|  .|   || |. | |  ..  | .  |.   ||  |.  .. || .|  |      . | |||  ..   | .  .. |   .| .. .      .  
plpntiadfwrmvwenrcriivmlsresencrikcdrywpeqigge.qfsiygngnevfgtysve.lveviqdpe.reiit...rnirltfegetrditq

LAFSGWPDHGAPAEPHTALDIIK--------YCES--FKTNVLVHCSVGVGRTGTLVA
  . |||||  |   .   ....           |   .  ..|||| |||||||...
yqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfct
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1036-1222 1e-06 22.4 In-house 97-281 (302) alignment 
Range on Protein: 1036-1222
Range on HMM: 97-281/302.0
VPKKDTR---EKFWGMIEEYRTGVVAQLCQfKEDGENKCAEYYSTEVKGEMKFGRYTVKTVSVEENLDQFtDKQTAKVYTIEFHNnKVLMKVpfpvkiLA
.||.|.    |.|| |. . .   |  | . .|. ..   |.. ..     ..|.  | .  ||.  ..  .. .  |   .. |  ||..|        
lpkvdsedsveeFWrmvfqekivsvvilvg.eeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsn.svlanv......yv

FSGWPDHGAPAEPH----TALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCI
.. |...  | .      || .. .  .. . |...    |.|| |....    ..   |..   .. .|  .|. |  ||.. .| . . ...
ltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_DSP15_pd Subfamily DSP15 1094-1179 1.3e-06 22.6 In-house 15-98 (151) alignment 
Range on Protein: 1094-1179
Range on HMM: 15-98/151.0
SVEENLDQFTDKQTAKVYTIEFHNNKVLMKvpFPVKILAFSGWPDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAI
 . .. .. ..|. ... ...  ..|.| .  .  |..| |  |.       . . ..|  | . . |||||| .|| |  |||..
rdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvva
PTEN_1 1135-1178 1.8e-06 22.9 In-house 101-149 (196) alignment 
Range on Protein: 1135-1178
Range on HMM: 101-149/196.0
GWPDHGAPaEPHTALDIIKYCESF------KTNVLVHCSVGVGRTGTLVA
...|||||   .  .||.| ...       . .|||||  |.||.||.||
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1163-1225 1.9e-06 22.2 In-house 2-64 (69) alignment 
Range on Protein: 1163-1225
Range on HMM: 2-64/69.0
LVHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKA
.|||| | |||||..||   .     . . |.   |  .| ||   |  |.. |..   . .|
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1164-1225 3.5e-06 21.3 In-house 2-63 (69) alignment 
Range on Protein: 1164-1225
Range on HMM: 2-63/69.0
VHCSVGVGRTGTLVAIKYGIQLCSKQEVSDMALVVDPVRACRYGAVQTEQQLIYMLLCITKA
|||| | |||||..||   .     . . |.   |  .| ||   |  | . ...   ...|
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_egg_pd Subfamily egg 1036-1186 3.9e-06 20.8 In-house 90-228 (307) alignment 
Range on Protein: 1036-1186
Range on HMM: 90-228/307.0
VPKKDTREKFWGMIEEYRTGVVAQLCQFKEDgeNKCAEYYSTEVKGEMKF--GRYTVKTVSVEENLDQFTDKQTAKVytI--EfhnnkvlmkvpfpVKIL
 | |.| . || |. . .   .  |   ||   ..|  |.    .  ...  | . .... |... | .      |.  .  .              . .
aplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl..vGgd.............deer

AFSGW-PDHGAPAEPHTALDIIKYCESFKTNVLVHCSVGVGRTGTLVAIKYGIQLC
    |  |    .. .. | ...      . |.|..  || ...|||||.  .   
flehwqgdvnnssdvysplrvlrklrnlskpvvvqdilGvskaatlvaieiallsl
DSPc Dual specificity phosphatase, catalytic domain 1148-1178 8.5e-06 20.7 Pfam-A 62-92 (133) alignment 
Range on Protein: 1148-1178
Range on HMM: 62-92/133.0
ALDIIKYCESFKTNVLVHCSVGVGRTGTLVA
| ..|. .|. . .|||||  |. |..||..
avefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 1148-1178 8.5e-06 20.7 In-house 62-92 (133) alignment 
Range on Protein: 1148-1178
Range on HMM: 62-92/133.0
ALDIIKYCESFKTNVLVHCSVGVGRTGTLVA
| ..|. .|. . .|||||  |. |..||..
avefiekaeqkgkkvlVHCqaGisRSatlii