Synonym: CELE_W09C5.7, CELE_W09C5.7
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
subfamily_INPP5F_pd | Subfamily INPP5F | 52-547 | 1.2e-166 | 547.5 | In-house | 6-532 (951) | alignment | ||
Range on Protein: 52-547
Range on HMM: 6-532/951.0
LIGKISF--DEQHFLFFVVDSSVVACYRGTSAESSHSIRRIERVIAINVKSDGSVIKSQITPGSGTKLKQGTEKIMKFFAEKVTKA--------------
.||||.. .|...|..| .||...... ...||.... .||||.........| .... . ..|.....||.. .|...|.
vigkillvseeerkLvivsessilgllpvqkkeskkevvaiervakldlsekdskelekeectgliglielegkiivatiegkskvnnkkwdlididssg
--------------EPRPALLDDVLKLFNDsKDFYFCRSRDVTISSQKYFEKREAHTS---EDSFFWNKRMVGNLGEAKISD--KFTCPIMQGYVATSQL
. . ||... ||..| ..||.... |.| . || ......... ...||||| .. .| ... .. .|..|..||.|.|...
ylqlkeekeqneeeklekrlleelkkllsd.gsFYysldfDltntlqkrgleeksestddwderFfWNkfllkdlinyrdkldkefltpviqGfvetkei
EITdqiNAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQRGFKYRPPLIINRSVEETHGVFTEHFKRLK
.|. .. ...|.|||||..|||.|. |||||. .||||||||||||.. .. |||.|.|||.||||.|.| ||.|.. |.||.|||...|.||||..
sie...klkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqsgkkykpkikitrseeetqpaFdehfkeql
AHYDTpLVAVSLVDQRGRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDR
.|.. .| |.|..|...| |.... |.. |....||....||.|....| .|.....||.......|..|....|....|...||||.||||.|||||
kkygk.vvivnllsqkssekklskaykeqllkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldr
TNLVQGQISLFVVLQQAQRLGIFGPLCEPP-EVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAIN
||.|| .||. |. .| ..||.| | .. . | |.|.....||||||.||.|||||.|||||.||.|||||.||.||||.|.|||||...||..|||.|.
tNvvqqaiskavlelqleklglfepessiddeellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvid
IVTGQTEADENAEEEENEKEEEENISRMVTET
...|.....|..| ....|||.|. .| |
lllGklpkqevvelidpkkeekeeelrekeek
|
|||||||||
subfamily_SAC1_pd | Subfamily SAC1 | 142-524 | 1e-114 | 374.7 | In-house | 68-456 (458) | alignment | ||
Range on Protein: 142-524
Range on HMM: 68-456/458.0
LDDVLKLFNDSKDFYFCRSRDVTISSQKYFEK--------REAHTSEDSFFWNKRMVGNLGEAKISDKFTCPIMQGYVATSQLEITDQinaYLTITIISR
..|.| .|..|||. |.| | |. . .. .. ||||| .. .| . . ..|. |...|.. ...|.. . .. ..|||
ylkllelvlksetfYfsytydltnslqrlekvtsaalkerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnak...eikfilisR
RSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQRGF-KYRPPLIINrSVEETHGVFTEHFKRLKAHYdTPLVAVSLVDQR
|| |||.|| .||.|. ||||||||| |... .. |||| |||||..|||.. ||.| . .. . |... |..|.......| . | |.||||.
RsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsFvqvRGsiPllWsqkpnLkykPkvkls.esedsldafkkhldeqiely.genvlvnLvdqk
GRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQ
|.|..| ... . ....... . .|| |..|| ...|..|| ..|..|. .|. ........|..|||||||||||||||||.|| .. |. .|
GsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlklLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkq
AQRLGI--FGPLCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEAD
..||. . .| . | .... .||||.| .|.|||||.||| | || | |.|.|...||.||.|||| .| .||..|....|.. ..
leslgvlateskledsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrve
|
|||||||||
Sac_COG5329 | 52-538 | 3.3e-112 | 367.5 | In-house | 64-536 (1070) | alignment | |||
Range on Protein: 52-538
Range on HMM: 64-536/1070.0
LIGKISFDEQHFLFFVVDSSVVAcyrgtSAESSHSIRRIERVIAINVKSDgSVIKSQITPgsgtkL----KQ-GTEkimkffaekvtkaeprpallDD--
..| | . .. || .. ..| || ...| .|. | |... . . ...| . .. . | .
vlGlielegslflivitgkskva.....qvipgetiykilavdfislnnn.kwddeeies.....deasteklrse....................hpcs
VLKLFNDSKDFYFCRSRDVTISSQKY-FEKREAHTS--EDSFFWNKR----MVGNLGEAKISDK-------FTCPIMQGYVATSQLEITDQinaYLTITI
|| . ||| . |.| . || .|. |. . ...|.||. .. . .... .| | .. .|.. | . .. . ..|.
elkkLlsngsFYfStdfditntLqkrlkeelelsvdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkk...tiaLtl
ISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQ-RGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYDTpLVAVSLV
|||||..|||.|.|.||.|. .||||||||| |. .. ||.| |||||.||.| .. . |.. |.||.|.| .| .||..| | .. | |.
ISRrSskragtRflarGvDddGnvanFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGd.vhivNLl
DQRGRELPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCW-VDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFV
.. ..| .| .|. .|. . .. .... .||.|.... .|.... |. .|..|.. |. |.|.... |.||.||||.|||||||..| .||. |
ktKssEieLseryekhlklsekpkihlteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrv
VLQQAQRLGIFGPLCEPpeVLVQTMQTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEADENAE
.|.| . ... . . ..| ....|||||| || .| || |||...|| | | . | ..| .|.||.|. |...|.||....|. . .|. |
lleqfrsikvisaidde..dflqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeave
EEENEKEEEE
.. .| .
lydpineyvn
|
|||||||||
subfamily_Synaptojanin_pd | Subfamily Synaptojanin | 143-531 | 1.3e-74 | 243.0 | In-house | 64-446 (754) | alignment | ||
Range on Protein: 143-531
Range on HMM: 64-446/754.0
DDVLKLFNdSKDFYFCRSRDVT--ISSQKYFEKREA-HTSEDSFFWNKRMVGNLGEAKI-SDKFTCPIMQGYVATSQLEITDQInayLTITIISRRSTRR
.. ||.. |. |||. |.| . .. .. ..|. ......||||. . .| .. .|.. ..| | | . .... ...||| |. |
ielkklla.sgtfyfsssadsasrldlslsaqrrkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakq...akaalisrlscer
AGARYLRRGIDEASNVANFVETELILNIFEHELSFVQCRGSIPVFWSQRGFKYRP-PLIINRSVEETHGVFTEHFKRLKAHYDTpLVAVSLVDQRGRELP
|| |. ||... ||||||||| .. . .. .|||| |||.|.||.| | . . ..|..| .. | |.. ||..| . | |.|. ... |
aGtrfnvrGvndeGnvanfveteqvillddkvtsfvqirGsvPlfWeqPGlqvGshkvklsrgfeasaaafdrhleqlkeryGe.vvivnllGskegeev
LAQRFLEH-CVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEET-LKTIGFcWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQR
| . | .| .. ..|| | .|| ||...| . .||..|.. . .. |.. .| .. | .||...|.||.|.||.||||||| || ..| |. .| .
lskafkkhlkasehakdvpfvkfdyhqkvkggkkeklekllkkqlklflesasf.flskgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlea
LGiFGPLCEPPEVLVQTMQTMWADNGDVISTQYAGTAALKGDVTrngerklMGVMKDGYNSASRYYLTHTKDAQRQKAINIVT-GQTEADENAEEEE
|. . . . . ......| ||| ||. |||| ||.|.. .. .||| | .| |...|.||... |.| .| |..
lk.lsskesvvsrfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgarsvartiqnnfldsskqeaidllllgntyveeladkar
|
|||||||||
Syja_N | SacI homology domain | 52-371 | 3.6e-74 | 240.8 | Pfam-A | 4-318 (319) | alignment | ||
Range on Protein: 52-371
Range on HMM: 4-318/319.0
LIGKISFDEQHFLFFVVDSSVVACYRgtsaeSSHSIRRIERVIAINVKSDGSVIKSQItpgsgtklkQgtekimkffaEKVTKAEPRPALLDDVLKLFnD
..| |.......|... ... || .| .|.| .|..| .|...|. . . . . || .. . || . ||.
ilGlirllsesyllvitkrekvakir.....gehpiykiksvefiplnseeeessaie.........e..........ekeeeekeeekllkllkkll.s
SKDFYFCRSRDVTISSQKYFEKRE-A-----------HTSEDSFFWNKRMVGNLGEAK-ISDKFTCPIMQGYVATSQLEITdqINAYLTITIISRRSTRR
|. |||. . |.| | |. .||.| . . .. |.||. .. .| |.| .....|..||.| ....|. . ...|.|||||..|
sgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievk..skkkveltLIsRrsvkr
AGARYLRRGIDEASNVANFVETELILNIF----EHELSFVQCRGSIPVFWSQ-RGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYdTPLVAVSLVDQRG
||.||||||||. .|||||||||.|. . .. .||||.|||.|.||.| .....|. |.|| |.. .|..|||.|. .| . |.|.|....|
aGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLlekkg
RELPLAQRFLEHCVKA-----DDNDVTFFSFDLHQHCRGLNFQ
|| .| ... |.. | ..... . .||.|..|.| .|.
rEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
|
|||||||||
Syja_N | SacI homology domain | 52-371 | 3.6e-74 | 240.8 | In-house | 4-318 (319) | alignment | ||
Range on Protein: 52-371
Range on HMM: 4-318/319.0
LIGKISFDEQHFLFFVVDSSVVACYRgtsaeSSHSIRRIERVIAINVKSDGSVIKSQItpgsgtklkQgtekimkffaEKVTKAEPRPALLDDVLKLFnD
..| |.......|... ... || .| .|.| .|..| .|...|. . . . . || .. . || . ||.
ilGlirllsesyllvitkrekvakir.....gehpiykiksvefiplnseeeessaie.........e..........ekeeeekeeekllkllkkll.s
SKDFYFCRSRDVTISSQKYFEKRE-A-----------HTSEDSFFWNKRMVGNLGEAK-ISDKFTCPIMQGYVATSQLEITdqINAYLTITIISRRSTRR
|. |||. . |.| | |. .||.| . . .. |.||. .. .| |.| .....|..||.| ....|. . ...|.|||||..|
sgsfYfSydyDltrslqrksekeeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievk..skkkveltLIsRrsvkr
AGARYLRRGIDEASNVANFVETELILNIF----EHELSFVQCRGSIPVFWSQ-RGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYdTPLVAVSLVDQRG
||.||||||||. .|||||||||.|. . .. .||||.|||.|.||.| .....|. |.|| |.. .|..|||.|. .| . |.|.|....|
aGtRylrRGidddGnvANfvEtEqivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrY.gkivvvnLlekkg
RELPLAQRFLEHCVKA-----DDNDVTFFSFDLHQHCRGLNFQ
|| .| ... |.. | ..... . .||.|..|.| .|.
rEkkLseayeelinklnkklkekkklkyiefDfhkeckgkkfe
|
|||||||||
subfamily_FIG4_pd | Subfamily FIG4 | 173-524 | 1.1e-60 | 196.6 | In-house | 179-544 (569) | alignment | ||
Range on Protein: 173-524
Range on HMM: 179-544/569.0
KREAHTSEDSFFWNKRMVGNLGEAKISDKFTCPIMQGYVATSQLEITDQinaYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELIL----N-IF
. . .... | ||. .. | . . .. |. |.| |.... . ...|.|.|||.. ||||.|.||.... .||| |||| |. . .
eakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgk...siyvtliarrsskfaGarflkrGvnnkGdvaneveteqivheasegsl
EH--ELSFVQCRGSIPVFWSQR--GFKYRPPLIINRsVEETHGVFTEHFKRLKAHYDTPLVAVSLVDQ---RGRELPLAQRFlEHCVK------ADDNDV
.. |||| |||.|..||| .. .||. |.. |. . . ||..| .| .|.. . || . | || | . | |.... ... .
dsdryssfvqlrGsvPlyWsqdasklvtkPpikidv.vdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleef.eaaieylneflPeekkl
TFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQSQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGIFG-PLCEPPEVLVQTM
.. |.|... . . . |..| . |...|. |. .. | ...|.|.|||||.||||||| | |. . | ..||| . | .|. .
kyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiidesklefdsdvvrll
QTMWADNGDVISTQYAGTAALKGDVTRNGERKLMGVMKDGYNSASRYYLTHTKDAQRQKAINIVTGQTEAD
. .. | || .. ||.|. . | . ... .| .. .||| .||..|.|||. |. .
eelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspr
|
|||||||||
hSac2 | Inositol phosphatase | 529-620 | 1.3e-20 | 62.1 | Pfam-A | 2-96 (115) | alignment | ||
Range on Protein: 529-620
Range on HMM: 2-96/115.0
EEENEKEEEENISRMVTETIQFLVPTQQTVIAGWGLINAFQSS---DEIDTVVILTRSNLYIVTYEIDGEKMTDVQIVALEDINTIQTGTSGNNR
....| |.|| ..... . ....|.....| || |... .|. .| ..|..||.. ||...| . ||.|... ..||.|..|. || ..
skdpeiereelreqaiekckklvlpddeeliggWlLvsidhsnktlteeervLLLTdkalyvckYDfetekvtqferidLesikkieiGtysest
|