Gene Y113G7C.1 in Caenorhabditis elegans

Synonym: CELE_Y113G7C.1, Y113G7C.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP206_AA protein Get Run
CeleP206_AA_1147-1429 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1148-1444 2.3e-170 560.1 In-house 4-300 (301) alignment 
Range on Protein: 1148-1444
Range on HMM: 4-300/301.0
GDMKVWIISQDHQDADKTARFYNATMDQVYVTTLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTC
 ....||||.|..|.||||.|||.|...|.|||.|||..|.|..||.||||||. ||||| |||||...|||||||||||||.|||||||||||||.||.
kkiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlknts

EDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDT
||||||.|...|.||.||. .|||...||. |.......|||||||.|......|||......|.| |.|.||||...||||||...|.||..||.|...
edfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshael

FELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMTLGAVYRLIREYNFNMRMHTDLMKDFD
|.|||||||||.||||||||||||..|||||||||||||.||.|||||||||||||||.|||..|||||||||.|||||.||.|.|.........||
fdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeqlamfd
0036941 (Phosphotyrosine protein) phosphatases II 1186-1436 2.6e-66 219.3 In-house 31-287 (297) alignment 
Range on Protein: 1186-1436
Range on HMM: 31-287/297.0
MTKSLGYLHKDKHRYDGVPCKPLTAVEVmDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPP
.. .|   ...|.||  ... . | | . |...   |.|...........||||||||.||.|||| |.  .||  | ||.  ||.. .||| |. .. .
lsvallpenleknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleeg

SKLDIGRFQITTQSRQLILRDNVIERKLLVKDTtGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK------SENPIVVHCSAGIGRTTAFIGTE
. |  |.|..|..| . .| |... |.| |.|| |. |..||||... .||| ..| .. . ....|||.|      |..|..||||||.||. .||. .
esltygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaad

YLAREVE---NDPKIELTEALKHLREHRWKGVQMRSQLYWMtLGAVYRLIREYNFNMRMH
.. . .|     ... . ||.|.|||.|.  ||. .|....   |.. |.. ... ... 
lmlqqledklkeggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepll
0040438 (Phosphotyrosine protein) phosphatases II 1178-1447 6.2e-66 218.2 In-house 27-293 (317) alignment 
Range on Protein: 1178-1447
Range on HMM: 27-293/317.0
VTTLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRVP---IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVK
. .|..|... .. . .|||.||  ... . . | . . |.. .   |.|...... ....||||||||.||.|||| |.  ..|  | ||.  .|....
llslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgre

KCAVYFASdpPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTtGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIG
||| |. .   ..| .|.|..|..| .    .... |.| |.|. |. |. ||||...  ||| ..|... . ....|.|...    ..|..||||||.|
kcaqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvg

RTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMtlgavYRLIREYNFNMRMHTDLMKDFDRVV
|| .||. ... . .|   .. ..||.|.|||.|...||. .|....     |....||  .  . ..... . ...
RtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl.....ydalleylkrkltlepaselklkll
0045450 (Phosphotyrosine protein) phosphatases II 1148-1417 4.3e-64 212.5 In-house 9-296 (307) alignment 
Range on Protein: 1148-1417
Range on HMM: 9-296/307.0
GDMKVWIISQDHQDADKTARFYNATMDQVYVTTLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRVP----IHANWI--------PTHGHPHR
 |.....  .  . .|  .... .  . . ||. . .... .| . .|||.||  ... . | | ... .....    |.|...        ... ....
idalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrk

FIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDpPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKFEPKTVTHYQHVKW
||||||||..|.|||| |.  ..|  | ||.  ||.. .||| |. ..  ..| .|.|..|. | .    |... |.| |.|. |..|. ||||... .|
fIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgw

PDRDTPKTHVDTFELMELVKK------SENPIVVHCSAGIGRTTAFIGTEYLAREVENDPK---IELTEALKHLREHRWKGVQMRSQLYWM
|| ..|..  ......|.|.|      ...|..||||||.||| .||.  .. | .|....   . | ||.|.|||.|...||  .|... 
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 1181-1418 3.9e-62 205.7 In-house 55-292 (308) alignment 
Range on Protein: 1181-1418
Range on HMM: 55-292/308.0
LDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVmdNGKRVPIHANWIPTH--GHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAV
 .  ... .|   .|||.||  ...   . | .  ...   |.|......  ..|..||||||||.||.|||| |.  .||  | ||.  ||....||| 
kplleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaq

YFASDPP-SKLDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS--ENPIVVHCSAGIGRTTAF
|. ...  . | .|.|..|. | .   .|... |.| .... .. | .||||...  ||| ..|    . ....|||.||  ..|||||||||.||| .|
Ywplelgggsleygkftvtllseev..lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtf

IGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMT
|  ..| . .| . .. . ||.|.|||.|.  ||  .|.... 
ialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfly
0047943 (Phosphotyrosine protein) phosphatases II 1183-1417 1.1e-60 200.8 In-house 27-264 (273) alignment 
Range on Protein: 1183-1417
Range on HMM: 27-264/273.0
KDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVmDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAS
  ... .|   .|||.||  ...   . | . ..|.   |.|...... ....||||||||.||.|||| |.  .||  | ||.  ||.. .||| |. .
lltysvallpenkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpl

DPPS-KLDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKFePKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK------SENPIVVHCSAGIGRTTAF
.  . .|  |.|..|. | .   .|... |.| ....  .  ..||||... .||| ..| .  . .|..|||.|      |..|.|||||||.||| .|
eggelsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

IGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
|  ..| . .|   .. . ||.|.||..|. .||  .|....
ialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0039614 (Phosphotyrosine protein) phosphatases II 1166-1417 2.2e-59 196.7 In-house 32-281 (297) alignment 
Range on Protein: 1166-1417
Range on HMM: 32-281/297.0
ARFYNATMDQVYVTTldkDnMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGK----RVPIHANWIPTHGH-PHRFIATQGPLDNTCEDFWAMCVYHNVD
 ....  .. . ..    | .. .| . .|||.||  ... . . | . ....       |.|...... . ...||||||||..|.|||| |.  ..| 
tllllefeellslkp...d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvt

KIAMLCLNVEKNVkKCAVYFASDPPsklDIGRFQITTQSRQLilRDNVIERKLLVKDtTGkfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK----
 | ||.  ||... ||| |. ..       |.|..|. . .   .|... |.| |.. .|  |..||||.|...||| ..| .. . .|..|||..    
vivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.ng..esrtvthfqytgwpdhgvppslellleflelvrealae

--SENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
  ...|..||||||.||| .||.  .. . .|   .. . ||.|.|||.|...||. ||... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 1184-1417 6e-59 195.2 In-house 39-278 (288) alignment 
Range on Protein: 1184-1417
Range on HMM: 39-278/288.0
DNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGK---RVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYF
 ... .|   ...|.||  ...   . | . . ..      |.|..|... ....||||||||.||.|||| |.  .||  | ||.  ||....||| |.
ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYw

ASdpPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTT---GKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTT
 .   ..| .|....|. | .    |... |.| |....   |. |..||||... .||| ..| .  . .....||.|.    ..|.|||||||.||| 
pl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtg

AFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
.||  ..| . .|.  .... ||.|.|||.|.  ||. .|... 
tfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
0046845 (Phosphotyrosine protein) phosphatases II 1184-1419 8.2e-59 194.6 In-house 18-268 (284) alignment 
Range on Protein: 1184-1419
Range on HMM: 18-268/284.0
DNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKR----VPIHANWIPTH-----GHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVK
 ... .| . ...|.||  ...   . | .   ...      |.|......      ....||||||||.||.|||| |.  .||  | ||.  ||....
lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengre

KCAVYFASDpPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS------ENPIVVHCSAG
||| |. ..  ..| .|.|..|. |..   .|... |.| ....  . |..||||... .|||...| .  | .|...||...      ..|||||||||
kcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaG

IGRTTAFIGTEYLAREVENDP---KIELTEALKHLREHRWKGVQMRSQLYWMTL
.||| .||  ..| . .|..    .. . ||.|.|||.|.  ||. .|...   
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvye
DSPc_SM00195 1185-1418 9.4e-59 194.2 In-house 17-255 (263) alignment 
Range on Protein: 1185-1418
Range on HMM: 17-255/263.0
NMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNG---KRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFA
..|..     |.|.||  ...   | |.. ..    .   |.||.| .. .....|||||||..|.|||| |.. ..|  |.||. ..|.. .||. |. 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SDPPSKLDIGRFQITTQSRQLILrDNVIERKLLVKDTTGkFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSEN----PIVVHCSAGIGRTTAFIG
..  .| ..|........ .    |..| |.| .. ..   |...||.||. .|||...|... ...||.. ||||..    |||||||||.||| .|. 
eesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

TEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMT
.... ...|.. |... | .|.||..| . ||.. |. .. 
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy
PTPc_SM00194 1185-1418 9.4e-59 194.2 In-house 17-255 (263) alignment 
Range on Protein: 1185-1418
Range on HMM: 17-255/263.0
NMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNG---KRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFA
..|..     |.|.||  ...   | |.. ..    .   |.||.| .. .....|||||||..|.|||| |.. ..|  |.||. ..|.. .||. |. 
etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdrywp

SDPPSKLDIGRFQITTQSRQLILrDNVIERKLLVKDTTGkFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSEN----PIVVHCSAGIGRTTAFIG
..  .| ..|........ .    |..| |.| .. ..   |...||.||. .|||...|... ...||.. ||||..    |||||||||.||| .|. 
eesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtfvt

TEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMT
.... ...|.. |... | .|.||..| . ||.. |. .. 
idiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiy
0043336 (Phosphotyrosine protein) phosphatases II 1180-1416 1.4e-58 193.9 In-house 31-268 (278) alignment 
Range on Protein: 1180-1416
Range on HMM: 31-268/278.0
TLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRVP---IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKC
. ..|... .| . .|||.||  ... . . | . . |.. .   |.|...... .|..||||||||..|.|||| |.  ..|  | ||.  ||....||
sfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkc

AVYFAsdpPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDtTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK----SENPIVVHCSAGIGRT
| |.     . | .|.|..|... .    |... |.| |.. .|. |..|||||....||| ..| .  . ..... |..    |..|..||||||.|||
aqYwp...ggsltygdftvtllkeeh..lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRT

TAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
 .||. ..| . .|.  .. | ||.|.|||.|.. ||. ||...
GtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf
Y_phosphatase Protein-tyrosine phosphatase 1194-1417 5.5e-57 188.2 Pfam-A 1-229 (235) alignment 
Range on Protein: 1194-1417
Range on HMM: 1-229/235.0
HKDKHRYDGVPCKPLTAVEV-MDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGR
.|.|.||  ...   | |..  ..|.   |.||.. .. ....||||||||..|.||||.|.. ..|  |.||. ..||. .||| |. ..   .|  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FQITTQSRQLILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSE----NPIVVHCSAGIGRTTAFIGTEYLAREVEND
.........    .... ||| .|..... |...|..... .|||...|..  . ..|.. |.||.    .|.|||||||.|||  |.  ..| ...|..
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

PKIELTEALKHLREHRWKGVQMRSQLYWM
 .... ...|.||..| . ||  .|....
eevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 1194-1417 5.5e-57 188.2 In-house 1-229 (235) alignment 
Range on Protein: 1194-1417
Range on HMM: 1-229/235.0
HKDKHRYDGVPCKPLTAVEV-MDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGR
.|.|.||  ...   | |..  ..|.   |.||.. .. ....||||||||..|.||||.|.. ..|  |.||. ..||. .||| |. ..   .|  |.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

FQITTQSRQLILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSE----NPIVVHCSAGIGRTTAFIGTEYLAREVEND
.........    .... ||| .|..... |...|..... .|||...|..  . ..|.. |.||.    .|.|||||||.|||  |.  ..| ...|..
ikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleae

PKIELTEALKHLREHRWKGVQMRSQLYWM
 .... ...|.||..| . ||  .|....
eevdvlqivkelRkqRpgmvqsleqYifl
0040439 (Phosphotyrosine protein) phosphatases II 1185-1416 1.7e-56 186.9 In-house 2-237 (249) alignment 
Range on Protein: 1185-1416
Range on HMM: 2-237/249.0
NMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRVP---IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFA
... .| . .|||.||  ... . . | . . ... .   |.|..|..  ...|||||||||..|.|||| |.  ...  | ||.  ||.. .||| |. 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SdpPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTtGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK------SENPIVVHCSAGIGRTTAF
.   . | .|.|..|. | .    |... |.| .... .. |. ||.|.|...||| ..|..  |.....|.|.|      ...|..||||||.||| .|
l..ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

IGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
|.  .. . .|   .. | ||.|.||..|...||. .|...
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
0042113 (Phosphotyrosine protein) phosphatases II 1192-1417 5e-56 185.2 In-house 7-235 (245) alignment 
Range on Protein: 1192-1417
Range on HMM: 7-235/245.0
YLHKDKHRYDGVPCKPLTAVEVMDNGKRV---PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASdpPSKL
. .|||.||  ... . | | ... | .    .|.|...... ....||||||||..|.|||| |.  ...  | ||.  .|.. .||| |. .   ..|
penkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..gesl

DIGRFQITTQSRQLilRDNVIERKLLVKDtTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK-----SENPIVVHCSAGIGRTTAFIGTEYLAR
 .|.|..|. | .    |... |.| |.. .|..|...|.||... ||| ..| .. . ....|.|.|     |..|..||||||.||| .||.  ....
tygdftvtllseeh..lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

EVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
 .|   .. | ||.|.||..|.. ||. ||....
qlekelgvsleeavkelrsqRpgavqtpsqyrfl
0045098 (Phosphotyrosine protein) phosphatases II 1182-1418 4.2e-55 182.4 In-house 21-265 (278) alignment 
Range on Protein: 1182-1418
Range on HMM: 21-265/278.0
DKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEvmDngkrvPIHANWIPTHghPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFA
. . .| .|   ..||.||  ... . . |   |      |.|..|...  |..||||||||..|..||| |.  ...  | ||.  ||....||| |. 
ipseitpalylgnldknRykdilpydhsrVk..d.....YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

SdpPSKLDIGRFQITTQSRQLIlrDNVIERKLLVKDT---TGKFEPKTVTHYQHVKWPDRDTPKTH--VDTFELMELVKK-----------------SEN
.   . | .|.|..|..| . .  |... |.||| ..      .|. .|||.. . ||| ..| ..     .||.| ...                 |..
e..ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIVVHCSAGIGRTTAFIGTEYLAREVenDPKIELTEALKHLREHRWK-GVQMRSQLYWMT
|..||||||.||| ....  .. . .  .... | ||.|.||..|.   ||. .|.... 
pvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfly
0037934 (Phosphotyrosine protein) phosphatases II 1187-1416 2.7e-50 166.5 In-house 3-233 (243) alignment 
Range on Protein: 1187-1416
Range on HMM: 3-233/243.0
TKSLGYLHKDKHRYDGVPCKPLTAVEVmdNGkRVPIHANWIPTHGhphRFIATQGPLDNTCED----FWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAs
. .| . ...|.|| .... . . | .  .|    |.||.|.  .   |.|||||||..|.||    || |.  .... | ||.  ||....||| |.  
siallpenlsknrysdilpydhsrvkl..eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

dpPSKlDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVK------------KSENPIVVHCSAGIG
   ..  .|.|..|. | .    |... |.||.. .  . ....|.||... ||| ..| .. |  .... |.            .|..|..||||||.|
..gev.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTTAFIGTEYLAREVendpKIELTEALKHLREHRWK-GVQMRSQLYW
|| ..|   .. . .    .. | ||.|.|||.|.  .|| .||...
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrf
subfamily_PTPRD_pd Subfamily PTPRD 1222-1435 1.3e-44 147.8 In-house 79-290 (564) alignment 
Range on Protein: 1222-1435
Range on HMM: 79-290/564.0
IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDpPsKLDIGRFQITTQSRQLIlrDNVIERKLLVkDTTGK
| |..| .. ... .||||||| .|.|||| |.  .|.  | ||   .||. .||. |. ..   .  .|....| .. . .   ... |.. .  .. .
INAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeel..adyeirtfkl.kkkks

FEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQlYWM
 | ..|.......|||.. |..  .  .|.. |...    . |||||||||.||| .||  ... . .... .... . .|.||..|   || ..| |  
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQ.YiF

TLGAVYRLIREYNFNMRM
   |..  .  .| ....
iheailealacgnteves
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1194-1416 7.5e-44 144.7 In-house 48-278 (305) alignment 
Range on Protein: 1194-1416
Range on HMM: 48-278/305.0
HKDKHRYDGVPCKPLTAVEVMDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIG--
...| ||  | |     | .        ||||.. |   |.||| || ||..|| ||| ||. ..|..| |||  .||  |||. ||||.   .|..   
eagknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeek

RFQITT---QSRQLILRDN---VIERKLLVKDTTGKFEpKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREV
  .|.     | .| .|..   ....  || . .|.   . ||||  . ||||  | . .  .||.|  . |  ||||||||||||| . .  ||.  ..
gqkisvkfessvtlkfrkdakakvtetvlviegpgeka.rkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildql

ENDPKIELTEA-LKHLREHRWKGVQMRSQLYW
 .  .|| |.  |...|| | . .|   |  .
lagqiiedtdkilqkireqrnnsiqtdaqylf
subfamily_PTPRB_pd Subfamily PTPRB 1162-1417 4.8e-41 135.7 In-house 21-277 (293) alignment 
Range on Protein: 1162-1417
Range on HMM: 21-277/293.0
ADKTARFYNaTMDQVYVTTLDKdNMTKSLGYLHKDKHRYDGVPCKPLTAVEV---MDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHN
||  .|| .  ....     |. .....     ..| ||  .     . |..    |. .   | ||.|| .  |. |||||||| .| .||| |.  ..
adsdlrfse.eyeelkavgkdq.avkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekk

VDKIAMLCLNVEKNVKKCAVYFASDPPSKlDIGRFQITTQSRQLilRDNVIERKLLVKDttgKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK--
.  | ||   |||  .||  |. .|  .    |  ..| .. .    .. . |.|...    . | ..|..|... ||| . |..     .... |..  
ssiivmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeee..ledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

----SENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
    |..|||||||||.||| .||  . | ...|..  ....  . .|||.|   ||  .|  ..
ektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi
subfamily_PTPN12_pd Subfamily PTPN12 1220-1427 4.9e-41 135.5 In-house 69-278 (290) alignment 
Range on Protein: 1220-1427
Range on HMM: 69-278/290.0
VPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLILRDnVIERKLLVKDTt
  | ||.|     ....||.|||| .| .||| |  ..||  . |.| .|| . |||. |...   ..| .| |..|... . .  |  . | | |.   
dYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd.flirtLkveaq.

gkFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK----SENPIVVHCSAGIGRTTAFIGTEYLAREVEN---DPKIELTEALKHLREHRWKGVQMRS
   | ..|. ... .|||...|... . .||.|||..    ...|.|||||||.||| . |  .|  . ...   ...... . . .||..|   || . 
..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtke

QlYWMTLGAVYRLIR
| | .   ||  |..
q.yelvykavaelvq
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1181-1416 1.2e-40 134.4 In-house 33-270 (288) alignment 
Range on Protein: 1181-1416
Range on HMM: 33-270/288.0
LDKDN-MTKSLGYLHKDKHRYDGVPCKPLTAVEVMD---NGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKC
|.|..  |..     ..| ||  .     ..|.. .   . .   | |..|  ... ...||||||| .| .||| .   ...  |.||   ||.. .||
lektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkC

AVYFASDPPSKlDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKFepkTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS--E--NPIVVHCSAGIGRT
  |. ..   |   | ...| .. .    .....||||.. .....   ..|.||.  ||| . |. . . .||.. || .  .  .||.||||||.|||
eeYWPdadkpk.nyGsvtvtlveske..ledfvlrklllekkktel...eitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrt

TAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
  ||  . |  .||.. .|........||..|   ||  .|  .
gtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYef
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1195-1417 1.3e-40 134.3 In-house 42-268 (281) alignment 
Range on Protein: 1195-1417
Range on HMM: 42-268/281.0
KDKHRYDGVPCKPLTAVEVMDNG---KRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAsDPPSKLDIG
. |.||  .     | |.| .|    .   | ||..|.   ....||||||. .....|| | . ..|..|.|.  ..|..  ||  |.  |. |.| .|
vlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnselkyg

RFQITTQSRQLilRDNVIERKLLVKDTTGkfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELV-----KKSENPIVVHCSAGIGRTTAFIGTEYLAREVE
 .........   . . ||||. .. ..|  |...|.. ....|||   |.|  . .|  . |     ||.. |.|.|||||.||| ..|. . |...||
dvtvkstaeee..katyierkfkleresg..etreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkave

ND-PKIELTEALKHLREHRWKGVQMRSQLYWM
.. ....... ...||..|   ||   |  ..
aeleeldvkavvaelrkernlmvqtvvqyefv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1193-1417 1.7e-40 133.5 In-house 54-281 (305) alignment 
Range on Protein: 1193-1417
Range on HMM: 54-281/305.0
LHKDKHRYDGVPCKPLTAVEVMDNGKRVPIHANWIPTHGHP-HRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIG
. . | ||. |||. ..|| . .      ||||..     | .|||..|||||.| ..|| | . ..|..| |||  ||    ||| |.      ||.. 
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

RFQI--TTQSRQLILRDNVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLA-REVEND
   .       . . ||. |.  ||    .|. .  .| | |  .||||  |  .. ..||.  .. |. ||||||||||||| . .  ||.  .  || 
sgivvenvsgskpmerdaeiqitllnltysgd.qkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenk

PKIELTEALKHLREHRWKGVQMRSQLYWM
|   . | .| ||..|   .|   |  ..
pcppmpelvkalrdqrafsiqndvqylfi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1186-1417 3.2e-40 133.0 In-house 33-269 (307) alignment 
Range on Protein: 1186-1417
Range on HMM: 33-269/307.0
MTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRV-PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDP
.|        || ||. |.|.  . . |  .|     ||||.. .  .|..||..||||.||  .||||.. ..|. . |||  .|    ||  |.  . 
vtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywplee

PSKLDIGRFQITTQSR-----QLILRDNVIERKLLVKDTTGKfePKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTE
  ||  |    |         .|   ...|.   |  | ..|   .|..|.|  .|||| .|.. . . .|.| |.  .||.|||||||.||. . ..  
gqklvfgeapntisvanlgakklapdedlinvttlkvdwaqk..srtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivais

YLARE-VENDPKIELTEALKHLREHRWKGVQMRSQLYWM
..    ..     .. . .. ||..|   .|   |  ..
lvqdkmiaGinckdmkklveelrsqrhyaiqteaqylyl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1196-1419 4.4e-40 132.2 In-house 58-276 (290) alignment 
Range on Protein: 1196-1419
Range on HMM: 58-276/290.0
DKHRYDGVPCKPLTAVEVMDNGKRVPIHANWIptHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQI
 | ||  |.|   | | . | ..   .|||..  .|    || |||.| .|  |.| | . ..|  | |||  .|.   ||. |.       | .| . .
kknrykdvvcndktrvilkdGydGdyvhanyv..kGlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitv

TTQSRQlILRDNVIERKLLVKDTTGKFePKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTE
.    .    .|.| . | |.|       . . |.. . |||.  ... .  . ..  ..|   |.||||||||||| .|.  |  .. . .  ...| .
lcseed.dkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlld

ALKHLREHRWKGVQMRSQlYWMTL
  . ||. | . ||.  | | . .
lvralrnsrlnsvqvdiq.ylalv
subfamily_PTPN13_pd Subfamily PTPN13 1192-1416 1.7e-39 130.8 In-house 35-260 (273) alignment 
Range on Protein: 1192-1416
Range on HMM: 35-260/273.0
YLHKDKHRYDGVPCKPLTAVEVMDNGKrvPIHANWI--PTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLD
  .||| ||  |     | |.. |.|    | |..|  |   . ...||.|||| .|..||| |    ... |||. |..||.  ||  |. .   .|| 
kenkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklk

IG-RFQITTQsrQLILRDNVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFEL---MELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREV
.  |....    ..  .|.   |.| |||.  . | . |.| . ||||| ..|.. ..  ..   .  ..... ||||||||||||. ..|  . .   .
vsnrlevell..kvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvlgli

ENDPKIELTEALKHLREHRWKGVQMRSQLYW
|.| .....| ...||| |   || . |  .
erdkefdvkeivrklreqrqgvvqtkdqyif
subfamily_PTPN3_pd Subfamily PTPN3 1195-1417 5.3e-39 128.8 In-house 42-267 (280) alignment 
Range on Protein: 1195-1417
Range on HMM: 42-267/280.0
KDKHRYDGVPCKPLTAVEVMDNGKrVPIHANW----IPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASdPPSKLDI
 .| ||  .     | |.. .. .   | ||.    ||..|   |.|||||||..|..||| |   ...  | ||  .||.  .||  |. . .  .|. 
lsknryrdilpydatrvklkeset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeley

GRFQITTQSRqlILRDNVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVE
|.|... ...    . ... |.|..||.. | | ..... |.. ||| . |. . | .|..| |.|     |.|.|||||||||||  .|  |     .|
gefsvkceke..detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalie

NDPKIELTEALKHLREHRWKGVQMRSQLYWM
.  ..   . ....|. |   ||  ||  ..
aaepvypldivrtmrdqramlvqtasqykfv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1182-1434 1e-38 128.2 In-house 36-291 (319) alignment 
Range on Protein: 1182-1434
Range on HMM: 36-291/319.0
DKDNMTKSLGYLHKDKHRYDGVPCKPLTAV---EVMDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAV
..|.....     |.| ||  .     | |   |. .  .   | |..| .. . ..|||||.||.|| |||| |   ...  . ||.  |||   |.  
vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkk

YFASDPPSklDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSE-----NPIVVHCSAGIGRTT
|. .  .   . ||. .| ....    ...| ||| ..  ... | ..|.|.|. .||| | |..     .|.. ..||       |||||||||.||| 
ywpeenfe..eyGrlivtleeeee..ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtG

AFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQlYWMTLGAVYRLIREYNFNMR
.||  .     |...  ... .  ..||  |   ||  .| | .   |.   .  .. ...
tfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq.Ykfiyealleaveagdteie
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1164-1414 3.4e-38 126.5 In-house 23-272 (305) alignment 
Range on Protein: 1164-1414
Range on HMM: 23-272/305.0
KTARFYNATMDQVYVTTLDKDNMTKSLGYLHkDKHRYDgVPCKPLTAVEVMDngKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIA
.    |.. ...   . ..|... |.   |. ..  .|      ||. | .|  ..  | |... .. . ...|..||||.|| .||| . |   | .| 
gleaqykslyeeeesidvgkkeankaknrlk.eitlld.ddriiltekesld..dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLIlrDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----EN
||.  || . .||  |..     | ..|.|... .|.. .   . ||||| .    .. | .||..||  .|||   |..     .|.. |.|.    ..
mltklveggkdkCrqYWpesktekkefgefsvelksekta..sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

-PIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
 |..||||||.||| .||  .     ....  ... | ||.||..| | ||   | 
vpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqY
0041856 (Phosphotyrosine protein) phosphatases II 1195-1421 4.7e-38 126.0 In-house 2-167 (182) alignment 
Range on Protein: 1195-1421
Range on HMM: 2-167/182.0
KDKHRYDGVPCKPLTAvevmdngKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClnveknvkkCAVYFAsdppskldigrfq
.||.||  ... . .            |.||..    .. |||||||||..|..||. |   ...  | .|.         .  |..             
ldknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.............

ittqsrqlilrdnvierkllvkdttgKFEPKTVTHYQHVKWPDRDTPKtHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREvendpKIELT
                          .........|... ||| ..|    ......| |.....|..||||||.||| ....  .. .      .. |.
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvsle

EALKHLREHRWKGVQMRSQLYWMTLGA
||.|..|..|...|.. .|...  | .
eavklvrsrRpgmvitpnqyfflqlal
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1193-1418 6.5e-37 122.0 In-house 34-263 (285) alignment 
Range on Protein: 1193-1418
Range on HMM: 34-263/285.0
LHKDKHRYDGVPCKPLTAVeVMDNGKRVPIHANWIPTHGHP-HRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIG
   |  ||  | |   | | |. |  |  |||.|.   |.    .|.||||| .|  ||| |    ..  . |||  .|  |.|||.|.       . .|
anpdlnryadvrcieetrv.vlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfg

RFQIT-TQSRQLILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK---SENPIVVHCSAGIGRTTAFIGTEYLAREVEN
...|| |. ..  .   ...   ...      ||  . | |   |||. .|.      || . |||    |.||.||||||.|||..|.| .| .  . .
kyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirime

DPKIELTEALKHLREHRWKGVQMRSQLYWMT
.|.||. . .. .|  |.. || . |. .. 
npniemldivremramrfqavqshmqflfly
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1198-1417 6.6e-37 121.9 In-house 24-256 (270) alignment 
Range on Protein: 1198-1417
Range on HMM: 24-256/270.0
HRYDGVPCKPLTAVEVM---DNGKRVPIHANWIP-THGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRF
 || ..  .| | | .    .. .   | ||...  .|.....||..|||..| ..|| | . ..|  |.|.   .||. |||..|....| .|...   
nRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledg

QITTQSRQLILRDNVIERKLLVKdTTGKFepKTVTHYQHVKWPDRDTPKTHV---DTFELMELVKKS---------ENPIVVHCSAGIGRTTAFIGTEYL
.|.. . .   ..  | ..| .. ..|.   . ..|.....|||.  |...    .| .|......          ..|..||||||.|||  .| ... 
kikvlalseekeegyiltrlrle.ekgee..rrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDia

AREVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
 | .|.. |..... ...||..| . ||   |  ..
vrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1186-1418 2e-36 120.6 In-house 38-272 (318) alignment 
Range on Protein: 1186-1418
Range on HMM: 38-272/318.0
MTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRV---PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAS
 .|||    | | ||  .     | |.. .  . .    | ||.|. . . . .||.|.|| .|.|||| |    |   | ||   .|.  .|.. |. |
slkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPs

DPPSKldIGRFQITTQSRQliLRDNVIERKLLVKDtTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSE-----NPIVVHCSAGIGRTTAFIG
. . .  .|. ... ...     .. . |.. |.  |.. | ..|  |.. .|||...|.  ..  .|.  |.| .     .|||||||||.|||  || 
kgsrs..ygklvvelkeev..elsdyvlrefkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfia

TEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQlYWMT
 . | . ....  ... .  |.|||.|   || ..| | . 
vdillerikaealvDvfqtvkqlreqrnlmvqtedq.yefi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1195-1415 2.3e-36 120.3 In-house 29-258 (274) alignment 
Range on Protein: 1195-1415
Range on HMM: 29-258/274.0
KDKHRYDGVPCKPLTAVEVMDNGK----RVPIHANWIPTH-GHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLD
. | ||  .   . . | .  .         | ||.|    .. . ..|||||| || .||| |  ...|..| ||    |.| .||||||  .   ...
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

IGRFQITTQSRQLILRDNVIERKLLVKDTTGkfePKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSE-------NPIVVHCSAGIGRTTAFIGTEYLA
    ..  . .. . |..   |||..| ..    ...|.|| . .|||...|.     ..|.. |..|.        |.||||||||||| .||...   
erygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

REVENDPKIELTEALKHLREHRWKGVQMRSQLY
|..... .... .   .|| .|   || ..|  
rqlreeivvdvlkivcnlrldrGGmvqtseqye
0043147 (Phosphotyrosine protein) phosphatases II 1221-1417 2.9e-36 120.1 In-house 7-153 (172) alignment 
Range on Protein: 1221-1417
Range on HMM: 7-153/172.0
PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClNVeknvkkcavyfasdppskldigrfqittqsrqlilrdnvierkllvkDTTG
 |.|...... .|.|||||||||.||..|||.|.  .... | .|. .                                                 ...
yinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnlt.el...............................................lydp

KFEPKTVTHYQHVKWPDRDTPkTHVDTFELMELVKK-----SENPIVVHCSAGIGRTTAFIGTEYLArevendPKIELTEALKHLREHRWKGVQMRSQLY
... ... .|... ||| ..| .     |..|....     ...|..||||||.||| ...   ..        .. | ||....||.|...||  ||..
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqyr

WM
. 
fl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1197-1434 2.1e-35 117.2 In-house 46-281 (288) alignment 
Range on Protein: 1197-1434
Range on HMM: 46-281/288.0
KHRYDGVPCKPLTAVEVMDNGKrVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQIT
. ||. .|.  .| | . |. .   |.|| .... ...|.| .| ||. | | .| | .  .|. | |||  .||  .| |.|| |    |  |||.   
rdryenlprcditrvklsddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctv

TQSRQlILRDNVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEA
.. ..    | ...  ||    .|. |.. | .    .|.|   |. ..  . |.| .|. ..|||||.|||.|||...| .   .. .  |  . . . 
vkkkr.adidklvkvsllriskege.ekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsl

LKHLREHRWKGVQMRSQ-LYWMTLGAVYRLIREYNFNMR
|..|||.| | .|   | ||   .   . |.. |. .  
laklreerfkaiqtemqylyvhrcvleelllkkykvlre
subfamily_PTPRG_pd Subfamily PTPRG 1221-1432 8.8e-35 114.9 In-house 78-293 (563) alignment 
Range on Protein: 1221-1432
Range on HMM: 78-293/563.0
PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSklDIGRFQITTQSRQLILRDNVieRKLLVKDTTG
 | ||.|  . . . |||||||| .|..||| |   .||  | |.   ||.. .|| ||. .| .   ..| .|.| .... .   .|  |.| .|..  
YinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdese..tygalqvtlieeevlalytv..rtlviknlkl

K-----FEPKTVTHYQHVKWPDRDTPKTHvdTFELMELVKKSE------NPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQ
|      . |.|..|.  |||| ..|.    ...|.  .|.|        |||||||||.|||  .|  . | ...... .... . |||.| .|   ||
kkkkqcdteklvrqyhytkWPdhgvPehs..lpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvq

MRSQLYWMtLGAVYRLIREYNFN
 . | ...   |.  .|.  . .
teEqYifl.hdalleaiaskete
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1222-1415 1.4e-34 114.3 In-house 79-273 (290) alignment 
Range on Protein: 1222-1415
Range on HMM: 79-273/290.0
IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDpPSKLdIGRFQITTQSRQLILrdNVIERKLLVKDTTGK
|.| .|  . . ...||||||. ||  ||| . . ..|  | ||.  .|.. .||  |...  ..|  .| |.|. .. . .   . ||||| ||... .
inAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetln..eyierklevknknsa

FEPKTVTHYQHVKWPDRD---TPKTHVDTFELMEL--VKKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLY
 ....||.||   |.. .    |.| . ..| |.    |. ...||||||...||.  |. ..     .. .  |.. . ||..|  . . ||   |. 
gakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq
subfamily_PTPN9_pd Subfamily PTPN9 1195-1417 6.4e-34 112.3 In-house 43-282 (297) alignment 
Range on Protein: 1195-1417
Range on HMM: 43-282/297.0
KDKHRYDGVPCKPLTAVEVMD---NGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIG
  | ||  | |   | | .     . .   |.||..  . ... ||||||||..|..||| |   ..|  | |    ||.   ||. |. ..  |  . |
leknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefg

RFQITTQSRQliLRDNVIERKLLVKDTTgKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK-----------------SENPIVVHCSAGIGRTTA
 ..... . .   ...  .|.| .|... . | ..|||.| . |||  .|..  . ....| |..                 |. ||||||||||||| .
dlsvsnveve..eeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGt

FIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWM
||  ..   ..|.  .....|..|.||. |   .|.  | .. 
fitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefc
0051429 (Phosphotyrosine protein) phosphatases II 1222-1422 1.4e-33 112.1 In-house 7-222 (272) alignment 
Range on Protein: 1222-1422
Range on HMM: 7-222/272.0
IHANWIPTHGH---PHRFIATQGPLDNTCEDFWAMcVYHNVDKIAMLCLNVEKNVKKCAVYFA----------SDPPSKLDIGRFQITTQSRQliLRDNV
|.|..... |.   |.|.....|||..|..|||..   .... | .|.  .|..  ||  | .          .| .    .|.. .|..| .  | ...
iNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee..llldy

IERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHvdTFELMELVKKsENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIE--------LTEALKHL
| |.||.. . .  |. .|.|...  |||. .|.      ||.||. . ..|..||||||..||  ..   .|.. |. .  ..        | ||...|
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

REHRWKGVQMRSQLYWMTLGAV
|..| . ||   |...    ..
raqrpgavqteeqylflyeall
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1169-1416 3.4e-33 109.9 In-house 25-269 (287) alignment 
Range on Protein: 1169-1416
Range on HMM: 25-269/287.0
YNATMDQVyvtTLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMdNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLN
  ....||   | ..|..| ..    ||| |.  .  .    | .  . .   | | .| .. . ..||....|. ||  .|| .   .||  | ||| .
qftvleqv...tqredevthniasqnkdknRltqilvpdnyrvllk.gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqe

VEKNVKKCAVYFASDPPskLDIGRFQITTQSRQliLRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRD---TPKTHVDTFELME--LVKKSENPIVV
 |.. ..|  |....    . .| ..|.  ...    ...||||| || .. . ....|. ||  .|...    .|.| .  .| |     |... .|||
kendeevcyqyWpeeks..vvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivv

HCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
|||...||.. |.  .   ......  |.. . ||. |  . . ||  .|   
hCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykf
0049260 (Phosphotyrosine protein) phosphatases II 1227-1417 4e-33 109.6 In-house 2-142 (152) alignment 
Range on Protein: 1227-1417
Range on HMM: 2-142/152.0
IPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFasdppskldigrfqittqsrqlilrdnvierkllvkdttgkfepkt
|. ...|..|||||||..||..||| |   .... | ||.  .|..  ||. |.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

vtHYQHVKWPDRDTPKTHVDTFELMELV----KKSENPIVVHCSAGIGRTTAFIGTEYLArevendPKIELTEALKHLREHRWKGVQMRSQLYWM
  .|.|. |||  .|. .    .|....    .....|..||||||.||| ...   ..        ...| ||....||.|...|.  .||.. 
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1218-1416 1.1e-32 108.5 In-house 83-281 (298) alignment 
Range on Protein: 1218-1416
Range on HMM: 83-281/298.0
KRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKldIGRFQITTQSRQLilRDNVIERKLLVKD
.   | | .. .. . . |||||.|| .| |||| | . ...  | ||   .|..  |.  |. ..   .   |..... .|..     ..| ||| |..
esdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegket..ygeitvsllskee..fadlivrklkvsk

TTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS-----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRS
.. . . ..| . ....|||...|...   ..|.. |..|     ..|..|.||||.||. .||  . .   |... .... ...| ||..| . || ..
kkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqtee

QLYW
|  .
qYvf
subfamily_Ptp69D_pd Subfamily Ptp69D 1221-1430 1.6e-32 107.8 In-house 78-286 (307) alignment 
Range on Protein: 1221-1430
Range on HMM: 78-286/307.0
PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDppSKLDIGrfQITTQSRQLILRDNVIERKLLVKDTTG
 | |..| .. . ..||| |.|...| .||| |    .|  | ||    ||| |||| |.. .   .   |  .|  .  .    .. |.|.| |  .  
YinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie..devqyg..dilvklvseekhsdyiiReldvskkke

K----FEPKTVTHYQHVKWPDRDTPKTHVDTFELMELV----KKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRS
.     . . |. |..  |.|   |..    ..|.| |    |... ||||||||| ||.. |.  . |  ..... |... |  |.||..|   ||   
esgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsle

QLYWmtlgaVYRLIREYN
|  .     .|| . .|.
qYvf.....lyralldys
subfamily_PTPN6_pd Subfamily PTPN6 1208-1429 1.8e-31 104.2 In-house 68-296 (306) alignment 
Range on Protein: 1208-1429
Range on HMM: 68-296/306.0
LTAVEVMDNGKRV--PIHANWIP--THGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLdIGRFQITTQSRQli
 | | . ...      | || |   ..|. ...||||| |..| .||| | .  |   | |.  .||.. .||| |. .   ..   |. ..|. | .  
htrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek..

LRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS--------ENPIVVHCSAGIGRTTAFIGTEYLAREVE---NDPKIE
  .. | |.|.|. .. | | ..| .|.. .||| ..||      ...| |..         . ||||||||||||| .|| .. | . .|   .| .|.
sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadid

LTEALKHLREHRWKGVQMRSQlYWMtlgaVYRLIREY
. .. | .||.|   ||. .| | .    ||. |..|
iqklvksvreqrsglvqteqq.ykf....vykaikky
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1222-1430 2.4e-31 104.0 In-house 82-284 (297) alignment 
Range on Protein: 1222-1430
Range on HMM: 82-284/297.0
IHANWIPTHGHphRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClNVEKNVKKCAVYFASDPPSKldIGRFQITTQSRQliLRDNVIERKLLVKDTTGK
. | ....  |  |.|.|| | ..| .||||| . ..|  |.||  . ... |||| |.. .  ..   |   ....| .   |   |.|.| |.    |
vnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln.ddnerdkkcaryWsdkgvtt..fGdvsvvllsvs..ereGfikrelevtkgkak

FEpKTVTHYQHVKWPDRDTPK--THVDTFELMELVKK-----SENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
 . . |  ||.|.|||.. ..  .     .|.. |.|     .|.|..|||.||.|||. ..  .    |.... .... . .|.||..| . || . | 
ar.rvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqy

YWmtlgaVYRLIREYN
 .     || .. |. 
kf.....vyvavleal
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1222-1416 2.8e-31 103.6 In-house 40-233 (250) alignment 
Range on Protein: 1222-1416
Range on HMM: 40-233/250.0
IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClNVEKNVKKCAVYFASDPPSKldIGRFQITTQSRQLIlrDNVIERKLLVKDTTgK
| | .. ..   . |||||||| .| |||| | . .... | ||  |.. . |..  |.  . . |   |  ...  |..     ... ||| .  .. |
inasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLt.nLkesektyhqywPvekaek..yGdvtvsllskeef..adytkrklklskak.k

FEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSE-----NPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
 . ..| ....| |||.  |..    .||.. |..|.     .|..|.||||.||. |||  . .   .... .... . .| ||..| . |. ..|  .
aderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf
0036282 (Phosphotyrosine protein) phosphatases II 1222-1416 1.1e-30 101.9 In-house 5-161 (174) alignment 
Range on Protein: 1222-1416
Range on HMM: 5-161/174.0
IHANWIPTHGHPHRFIATQGPLDntcedFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASdppskldigrfqittqsrqlilrdnvierkllvkdtTGK
|.|...  .  . |.||.||||.     ||.|.  ...  . ||.  .|..  ||  |. .                                    . .
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lre

FEPKTVTHYQHVKWPDRDTPKTHVdTFELMELVKKS-----ENPIVVHCSAGIGRTTAFIGTEYLAREVEnDPKIELTEALKHLREHRWKGVQMRSQLYW
.. ... .|... |||. .| ...  .|....|..      ..|..||||||.||| ....  .. |  .  . ..  . .. || .| ..||. ||...
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
subfamily_PTPRA_pd Subfamily PTPRA 1222-1431 3.3e-30 100.1 In-house 89-296 (330) alignment 
Range on Protein: 1222-1431
Range on HMM: 89-296/330.0
IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDppSKLDIGRFQITTQSRQLIlRDNVIeRKLLVK---DT
| | .|  . . ..|||.|||...| |||| |   ..   | ||    |.. .||| |. ..    .  |  ... .  ...  |  . ||.||.   |.
inasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPde..GlvtyGnirvevedetvl.vdytv.rkflvqqlpda

TGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
| . ... |. .    |||   | . .  ..|.. |||      .|||||||||.||| .||  . .   |. . |... |..|.||  | . ||   | 
trekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqy

YWmtlgaVYRLIREYNF
 .     .|. ..|| .
ef.....iykvlleyyl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1194-1438 3.9e-30 99.6 In-house 43-288 (312) alignment 
Range on Protein: 1194-1438
Range on HMM: 43-288/312.0
HKDKHRYDGVPCKPLTAVEVMdNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFaSDPPSKLDIGRF
 ||  ||  . |       .    .   ||||..    .| ||..|||||.|||  || ...      | .||  ||   .||| |  ||  . .|.   
fkdlnrypniqcwdrgrftla.gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi.sdivgfvdledh

QITTQSRQLI-----LRDNVIERKLLVK-DTTGKfEPKtVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVEN
.. |..   |      .|..  | | |   .||. | | . |||   |||   | .   .. |.  |||  .|.. |||||.||| ...  | .   .  
rvyteycteieiggkskdkithrvlkvvvkatgq.esk.lnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrh

DPKIELTEALKHLREHRWKGVQMRSQlYWMTLGAVYRLIREYNFNMRMHTD
  | .. ...  ||  | . |..  | | ..| .|  ..    .  | . .
prkqnvkdsfvllrkdrarsvrvfpq.yvyalrcvleflyskglykrneqe
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1221-1414 4.9e-30 99.5 In-house 79-268 (315) alignment 
Range on Protein: 1221-1414
Range on HMM: 79-268/315.0
PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDppsKLDIGRFQITTQSRQLilRDNVIERKLlvkDTTG
 . ||.|. . ...|.||.|||. .. .||| .   ... || ||   ||.. .|.  |.  .   |.  |.. .| .| .    ...  | |    .. 
yvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseev..nteytvrtl...svvf

KFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKK----SENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
. . ..|  ...  ||| . ||  .   .|.  ||.    |  .||||||||.||| .||  . .  ..| .  |.. .... .|. | | ||.  | 
gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqy
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1211-1444 8e-30 98.7 In-house 63-297 (315) alignment 
Range on Protein: 1211-1444
Range on HMM: 63-297/315.0
VEVMDN-GKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLilRDNVI
.||.|.  ..  | |  |..  . . .||.||||. . .||| | . ..|  |.|.    | .  ||. |.        . | ..... | .     . .
leviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellslea..dtdgv

ERKLLVKDTTgkfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRW
 ||| ....    | .||| .|  .|||. ..|     ..|.  || .    | ...||||||.|||  .|  .    ....   ... . .| ||..| 
arklvtrkse...esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrp

KGVQMRSQlYWMTLGAVYRLI--REYNFNMRMHTDLMKDFD
. || . . | .  .||   .  |.    .   || ..|. 
ylvqteee.yafiydavledllwrntlilvihftdhlqdlh
0046846 (Phosphotyrosine protein) phosphatases II 1218-1416 1.2e-29 98.8 In-house 11-164 (176) alignment 
Range on Protein: 1218-1416
Range on HMM: 11-164/176.0
KRVPIHANWIPTHghphRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLdigrfqittqsrqlilrdnvierkllvkd
  . |.||.| ..    |.||||||| .|..||..|   .... . .|.  ||..  ||. |.      ..                             
dldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.............................

ttgkfepktvtHYQHVKWPDRDTPKThVDTFELMELVKKSE---NPIVVHCSAGIGRTTAFIGTEYLARevenDPKIELTEALKHLREHRW-KGVQMRSQ
           .|.|. ||| ..|    . .||.|....     .|..|||||||||| ...    | .    .  . . |||...||.|. . || ..|
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

LYW
...
yrf
subfamily_PTPRK_pd Subfamily PTPRK 1212-1415 2.3e-29 97.2 In-house 63-267 (314) alignment 
Range on Protein: 1212-1415
Range on HMM: 63-267/314.0
EVMDNG-KRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSkldIGRFQITTQSRQLilRDNVIE
 ..|.  .   | |..| .. .|. ||.|||||..| .||| .   .|   | ||   ||.   ||  |.  |       | ....  . .|    ... 
itidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetel..laelvv

RKLLVKD-TTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRW
| . |.  . |. | ..| ..|...||| |.|.     ..|.  ||||    . .|||||||| ||| .||  . .   .|..  ... .| | ||... 
rifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkv

KGVQMRSQLY
  |.   |  
nmveteeqyk
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1171-1417 2.9e-29 96.9 In-house 13-257 (283) alignment 
Range on Protein: 1171-1417
Range on HMM: 13-257/283.0
ATMDQVYVTTLDKDNMTkslGYLHKDKHRYDGVPCKPLTAVEVMDNgKRVPIHANWIP---THGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCL
 ..... |  || |  .      .| | |.. .  .    ||.  .  |  | | .||    . . ...|..|.|||.|  ||| |   ...  | ||  
evlkrlsvpdldadias...adenkrknrnqeivpadqwrvelkse.srdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

NVEKNVKKCAVYFASDppSKLDIGRFQITTQSRqlILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWpDRDTPKTHVDTF----ELMELVK-KSENPIV
  | . .||. |. ..     | | | .| .       .  | ..||..  .   .   ..||| . |     ... ....     .. | . . . |||
lqedlrikCsqyWPkr..GsedyGeftvtlrke..ttsnsfiikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPiv

VHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQlYWM
||||.|||||..||.      ..  .  ... . .| .||.|   || . | | .
vhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldq.ykl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1212-1423 3.6e-29 96.2 In-house 63-273 (515) alignment 
Range on Protein: 1212-1423
Range on HMM: 63-273/515.0
EVM-DNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLilRDNVIE
||. || .   . |  ||.    . .||.|||.. . .||| . . .||  |||.    | .  ||. |.   |   .  | ... . | .     . | 
evindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea..ctggik

RKLLVKDTTGkfePKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSEN----PIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWK
||| |         .||| ..  .|||. .||     . |.  || ...    |...|||||.|||  .|  .    ....   ... . .. .|..| .
rkltvlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpy

GVQMRSQlYWMTLGAVY
 || . | | .  ||| 
lvqtqeq.yafiygavl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1203-1434 2e-28 94.3 In-house 27-268 (290) alignment 
Range on Protein: 1203-1434
Range on HMM: 27-268/290.0
VPCKPLTAVEVMDNGKRVP---IHANWIpTHGHPHRFIATQGPLDNT-------CEDFWAMCVYHNVDKIAMLCLNVEKNVK----KCAVYFASDPPSKL
||    | |   . |||     |||| . |  .  |.|.|| |. ..        |.|| |    .|... ||| . ||. .     || |.      .|
vpLveatrvvLkgygkrfnddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeel

DIGRFQITTqsRQLILRDNVIERKLLVKdtTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVE-N
 .. ...     . .  |.|..|.|.||   .. |. ||||.. . | .. .....    .|.. ||.|. |..|||  || |  |.   .     .   
kfkgltvkC..kskekeddvetRelvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaet

DPKIELTEALKHLREHRWKGVQMRSQLYWMTLGAVYRLIREYNFNMR
  ...|...|| ||..| . ..   .| ..  |.| ..|....  ..
sgsvkledvlkalrkqralaitsalelafvdagivllaievldqfae
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1221-1419 2.9e-28 94.1 In-house 91-285 (319) alignment 
Range on Protein: 1221-1419
Range on HMM: 91-285/319.0
PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClnveknVKKCAVYFASDPPSKldIGRFQITTQSRQLIlrDNVIERKLLVKDTTG
 | | ..  . .. ..||.||||||| .||| |   .|.  | .|        .||. |.  .   |   .||..  .| .    .. . |.. . . . 
yinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsveet..aeyvvrdielsedgk

KFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELV----K--KSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
. . . .| .    |||   |.  .| . |.. |    .  . ...||||||||.||| ..|  . |   .... .... . .. ||. | . ||   | 
ekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqy

YWMTL
...  
kfiys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1222-1420 3.7e-28 93.8 In-house 56-250 (284) alignment 
Range on Protein: 1222-1420
Range on HMM: 56-250/284.0
IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClnveknVKKCAVYFASDPPSKldIGRFQITTQSRQLilRDNVIERKLLVKDTTGK
| | .|  . .....|||||||||| .||| |   .|.  | .|        .||. |.  .   |   .||..  .| .    .. . |.. . . . .
inasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik..eerfkvkvdsvee..seeyvvrdielsedgke

FEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVK------KSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLY
 . .... .    |||   |.  .| . |.. |.      . ...||||||||.||| ..|  . |   .... .... . .. ||. | . ||   | .
kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

WMTLG
..   
fiysa
subfamily_PTPN1_pd Subfamily PTPN1 1193-1417 5.9e-28 92.4 In-house 31-263 (290) alignment 
Range on Protein: 1193-1417
Range on HMM: 31-263/290.0
LHKDKHRYDGVPCKPLTAVEvMDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPP-SKLDIG
  ... ||  |     . .. .....   | |. .  .   ...| ||||| ||.. || |   ..   . ||   |||.  ||| |. ..   ..| . 
enrnlnryrdvspydhsrik.leradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellle

--RFQITTQSRQliLRDNVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS------ENPIVVHCSAGIGRTTAFIGTEYLAR
  .....  |..   ... . |.| ... . . | ....|. ...|||   |..    ....  |..|        | |.||||||||. .|.  . .  
dtklkvklisee..rksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclv

EVENDPK---IELTEALKHLREHRWKGVQMRSQLYWM
..|.  .   ... . | .||..|   .|   || . 
liekkddlssvdikkvllelrkyrlGliqtadqlrfs
subfamily_PTPN14_pd Subfamily PTPN14 1231-1414 2.2e-27 90.9 In-house 90-285 (300) alignment 
Range on Protein: 1231-1414
Range on HMM: 90-285/300.0
GHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASD--PPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKfEPKTVT
|. . .|..||||..|..||| |   ..|. |.||  . |.  .|.  || ..    .... |.|..||. ..    | || ..| .|    | | .|| 
gkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsed..sdsvittglklkhlpsk.eertvw

HYQHVKWPDRDTPKTHVDTFELMELVK-------------KSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
| |.. |||.. |.   . .. .| |.             .|. |..||||||.|||   | .. |   .|.. .|.. ..|..||| |   ||  .| 
hlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqY
subfamily_PTPN23_pd Subfamily PTPN23 1235-1416 3.2e-27 90.1 In-house 84-271 (288) alignment 
Range on Protein: 1235-1416
Range on HMM: 84-271/288.0
RFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLilRDNVIERKLLVKdTTGKFEPKTVTHYQHVK
 |||||.||..|  ||| | .   .  | ||  . |.. .|.. |. .|       | ...| .| .    ....||.| .. | .. . |.|.| |  .
dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvre..tethvervlkle.tldadavksvshlqlts

WPDRDTPKTHVDTFELMELVKK--------SENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKI-ELTEALKHLREHRWKGVQMRSQLYW
||.   |..  . ..... |..        |. |.|||||||.||| .|      .||.|... . .. . ...||| |   || ..||  
WpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkf
0049772 (Phosphotyrosine protein) phosphatases II 1171-1409 4.3e-26 87.8 In-house 23-263 (314) alignment 
Range on Protein: 1171-1409
Range on HMM: 23-263/314.0
ATMDQVYVTTLDKDNMTKSLGYLHKDKHRYDGVPCKPlTAVEVmD---NGKRVPIHANWIPTHghpHRFIATQGPLDNTCEDF----------WAMCV--
......  ..| .  ....  .|..|| ||  ... . . | . .   .     |.|... ..    .||||||||..|..||          | | .  
lvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrg

YHNVDKIAM---------------------LCLNVEKNvkkcavyfasDPPSKLDIGRFQittqsrqlilrdnvierkllvkDTT--GKFEPKTVTHYQH
 .||  | |                     |.   ...          . |.  |.  ..                      . .  ... .... .| .
dlnvrdivmsrdevladelsrLdaAlgKtpllildgng..........neptaadlellk......................eelydpelferlgikylr

VKWPDRDTPkTHVDTFELMELVKK--SENPIVVHCSAGIGRTTAFIGTEYLAREVendpKIELTEALKHLREHRW----KGVQ
. .|| ..| .  |  |..|....   ..|..|||.||.|||. |. . || .      .. | |||...|. |     .|  
ipvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfi
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1198-1417 1.5e-25 84.6 In-house 42-269 (287) alignment 
Range on Protein: 1198-1417
Range on HMM: 42-269/287.0
HRYDGVPCKPLTAVEVMDNGKR--VPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDpPSKLDIGRFQI
 ||  |     | | .  .|.     | ||..... . ..|||.|||.  |  ||| . . ...  ....  .||.  .||  |.       . .| . .
nryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysv

TTQSRQLILRDnVIERKLLVKDTTGKfEPKTVTHYQHVKWPDRDTPKTHVD-------TFELMELVKKSE--NPIVVHCSAGIGRTTAFIGTEYLAREVE
.  ...    .    | | . |  .. | . |  .. ..|||.  . | |          . .|| ....   |.|||...||||.  .. |  | .  |
vlldydikePe.ygvralrlidletr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrle

NDPKIELTEALKHLREHRWKGVQMRSQLYWM
.  ... . .. .|||.|   ||   ||  .
dlGrvdvaavvirlreyraalvqavvqlrll
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1246-1406 7e-25 82.5 In-house 40-202 (255) alignment 
Range on Protein: 1246-1406
Range on HMM: 40-202/255.0
TCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSrqlILRDNVIeRKLLVKDTTG-KFEPKTVTHYQHVKWPDRDTPKTH
| . |. . |  . ....|||   |..|.||  ||  .   || .   ..||        | |. | | .  | | | . .||.||..  |... .|.  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk...ssadvvl.rtleitstlgekkkthtvkhysykGWieknaPela

VDTFELMELVKKSeNPIVVHCSAGIGRTTAFIGTEYLAR----EVENDP--KIELTEALKHLREHRWK
 .  ... .|..|  ..|||||.||||..||. .|.. .     ... .  ...  . |..||..| .
reilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkr
0044763 (Phosphotyrosine protein) phosphatases II 1212-1418 1.4e-24 82.1 In-house 11-164 (178) alignment 
Range on Protein: 1212-1418
Range on HMM: 11-164/178.0
EVMDNGKRVPIHANWIPthghPHRFIATQGPldntcEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPskldigrfqittqsrqlilrdnvier
....     .|.|..|     |. ......|     .|....   .... | .|. ..| .  ||  |. ..                            
nleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..........................

kllvkdttgkfepktvTHYQHVKWPDRDTPKTHVDTFELMELVK----KSENPIVVHCSAGIGRTTAFIGTEYLAREvendpKIELTEALKHLREHRWkG
                 .|.|. .|| ..|     ..|..|...    ....|..||||||.||.....   .. .      .. | ||....||.|. .
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.i

VQMRSQLYWMT
|. ..||... 
vpnpgqlrqLy
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1214-1414 1.8e-24 81.5 In-house 71-277 (325) alignment 
Range on Protein: 1214-1414
Range on HMM: 71-277/325.0
MDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIaMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLIlRDNViERKL
 |...   | |... ..   . |.|.| || .| .|.| . .  .   . ..   .... ..||||.  .       | ...  .. . |  | |  |.|
kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvv.vvlneldlgkdrcavywpkemgksktfGglevklrtieei.sdyv.hrvl

LVKDTTgKFEPKTVTHYQHVKWPDRDTPK---THVDTFELMELV-------KKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREH
 ||..  | | ..|  .|.  |.|  ..|   | .   .|.. |        |.  ||.||||||.||| .||    .. .| .. .... . .|.||..
dvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkd

RWKGVQMRSQL
| . |.   | 
rpsmvetvdqy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1195-1387 3.9e-24 79.8 In-house 38-229 (281) alignment 
Range on Protein: 1195-1387
Range on HMM: 38-229/281.0
KDKHRYDGVPCKPLTAVEV---MDNGKR-VPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDI
. | ||  .||  .. |..   | | .    ||||.| .    . .| ||||  .|  ||| |    |   | |||  .| | .||| ||  .    |..
nkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqf

GRFQITTQSRQlILRDNVIERKLLVKDTtgkfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVEN
 .. .. .    . .  |  |  |  .     | . .||.   .||| . |..    ....  ..    | |.|||||.||. ...  |   . . .
dklsvsyedst.vnkslvttrlnlsyeg....etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihs
subfamily_hpo-7_pd Subfamily hpo-7 1245-1404 1.4e-23 78.2 In-house 45-206 (263) alignment 
Range on Protein: 1245-1404
Range on HMM: 45-206/263.0
NTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLilrDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDTPKTH
.| . |. . |  . ....|||   |..|.||  ||  .   |. .   ...|   |    | ..  . |..    | . .||.||... |...  |.  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWiekndpela

VDTFELMELVKKSeNPIVVHCSAGIGRTTAFIGTEYLAR----EVENDP--KIELTEALKHLREHR
 . .........|  ..|||||.||||. ||  .| . .     ... .  ...  . |..||..|
reilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssr
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1222-1415 4.8e-23 76.6 In-house 32-229 (237) alignment 
Range on Protein: 1222-1415
Range on HMM: 32-229/237.0
IHANWIPT-HGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKlDIGRFQITTQSRQlILRDNVIERKLLVKDTTG
| |...    | |...||.||||...|.||| |    .   | ||   .|.| .||  |. |    .   | . .. . ..  . |  .   ||.| .| 
inatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa.aygvltvslkkke.efsdytvrslllskrltl

KfEPKTVTHYQHVKWPDRDTPKTHVDTFELM-ELVKKSEN-----PIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
| | . .  ||   ||||  |.     . .  .....|.      | ..|||||.|||  |.  . . |. ..   ... . .. . | |   .| . | 
k.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqy

Y
 
v
WSN Domain of unknown function 173-239 1.2e-22 69.5 Pfam-A 2-68 (69) alignment 
Range on Protein: 173-239
Range on HMM: 2-68/69.0
NPADFLNHITVVAHVSNGITLQAGLMNGSIPIVEVVDELLDLGSAKVADLVSFKEDKITALVSKLKE
.....|......|.| |||.|||||.|||||| .|..|||..||.....|.....||. . . ||.|
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_PTPRN_pd Subfamily PTPRN 1235-1422 4.2e-22 73.2 In-house 101-288 (297) alignment 
Range on Protein: 1235-1422
Range on HMM: 101-288/297.0
RFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIgrFQITTQSRQlILRDNVIERKLLVKDTTGKfEPKTVTHYQHVK
 .||||||| .|  ||| |   . |  | .|.   |..||.|. |.  .  .  .|  ...   |   |  |. . | . .|.   . | .||| . .. 
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhi..yevhlvseh.iwcddylvrsfylknlqts.etrtvtqfhfls

WPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREV-ENDPKIELTEALKHLREHRWKGVQMRSQLYwMTLGAV
||....| .    .|.   | ||      |||||||.| ||| ..|  . .   .     .|... .|.|||. | . |. ..|.  ..|.||
wpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe.faltav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1230-1419 1.1e-21 72.1 In-house 47-234 (239) alignment 
Range on Protein: 1230-1419
Range on HMM: 47-234/239.0
HGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAsDPPSKLdiGRFQITTQsRQLILRDNVIerKLLVKDTTGKFEPKTVTH
 | |. .||||| .  .. ||| |        | ||   .|   |||  |.  |  ||     ...| . .  .. | .|  . .|    |. | . | .
dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsky..cnlrvtlr.ktevfadyii..rtfvmsqvgqteeryvyq

YQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMTL
|.   |||.  |.     . |   . |       | |.|||||.||| ||.  . . |. ...  ... . .| .|| | . ||   |  .. |
yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1241-1419 1.1e-21 71.5 In-house 98-282 (302) alignment 
Range on Protein: 1241-1419
Range on HMM: 98-282/302.0
GPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLILRDNVIERKLLV------KDTTGKFEPKTVTHYQHVK
 |  .|.| .||.   .||  .. ||  ||.. |||| |.. .   .|  ||. ..| | .  | .    ... .       . . |  .|||   ..  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDRDTPKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMTL
|||  .||    .....   .   . ..||||||.||| ...   |      ..   .| . .. .|. |.  ||  .|| .. |
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylll
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1230-1419 1.2e-21 71.9 In-house 48-235 (239) alignment 
Range on Protein: 1230-1419
Range on HMM: 48-235/239.0
HGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAsDPPSKLdiGRFQITTQsRQLILRDNVIerKLLVKDTTGKFEPKTVTH
 | |. .||||| .  .. ||| |        | ||   .|   |||  |.  |  ||     ...| . .  .. | .|  . .|    |. | . | .
dgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsky..cnlrvtlr.ktevfadyii..rtfvmsqvgqteeryvyq

YQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYWMTL
|.   |||.  |.     . |   . |       | |.|||||.||| ||.  . . |. ...  ... . .| .|| | . ||   |  .. |
yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1218-1417 1.8e-21 71.1 In-house 71-271 (439) alignment 
Range on Protein: 1218-1417
Range on HMM: 71-271/439.0
KRV----PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLClNVEKNVKkcavYFASDPPSKldIGRFQITtQSRQLILRDNVIER-K
  |     | ||.|  .  .. .|||||| ..|..||| . . ... .| ||. |. .  |    |. ||       |   .    |.. | . ||   |
pgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt.nlvesyk....ywpsdaevc..ygdiavr.vdrnielpnyvirgfk

LLVKDTTGKFEpKTVTHYQHVKWPDRDTPKTHVDTFELMELV-----KKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKG
.. .  |.. | .|| ..... |||.. |       ...  .     |.   |.|||||||.||| . |  .    ..  . |...   .| ||..| . 
vfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqm

VQMRSQLYWM
||   |  ..
vqalcqyvfi
0051082 (Phosphotyrosine protein) phosphatases II 1221-1416 3.6e-21 70.8 In-house 5-144 (151) alignment 
Range on Protein: 1221-1416
Range on HMM: 5-144/151.0
PIHANWIPTHghphrFIATQGPLDntceDFWAMCVYHNVDKIAMLCLNVEKNvkKCAVYFASDPpskldigrfqittqsrqlilrdnvierkllvkdttg
.|.....  .     .....|||.    ||...   .... | .|.  .| .  .|. |. .                                      
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

kfepKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS-ENPIVVHCSAGIGRTTAFIGTEYLAREvendpkIELTEALKHLREHRWKGVQMRSQLYW
     .|.|.. . ||| ..| .     |..||. .  ..|..||||||.||| ....   ...       . | |||...|..|.  ||   | . 
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1149-1414 5.1e-21 69.5 In-house 13-279 (310) alignment 
Range on Protein: 1149-1414
Range on HMM: 13-279/310.0
DMKVWIISQDHQDADKTARFYNaTMDQVYVTTLDKDNMTKslgYLHKdkHRYDGVPCKPLTAVEVMDNGKR--VPIHANWIPTHGHPHRFIATQGPLDNT
 .. .||. ..   .  .. |   .|    ..|  . ..|   |.||   ||  | |.  . | .  .  |    ||||.. |      || .||||. |
alenfiiateklgieglvkqyr.kldakqdssltyeaykk...ymhk..nrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqht

CEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKlDIGRFQITTQ---SRQL---ILRDNVIERKLLVKDTTGKFEPKTVTHYQHVKWPDRDT
  ||| |      . | .||  .|.   ||  |. |   ..   |  ..|     | ..    |    .  .. | .   ...   |.  .  .||||  
iidfwrmifqeraesilllckvgeegrpkcvgywpslgvte.tygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgv

PKTHVDTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
|  .. |     | .    | |||||||..|. . .  ..    ...  |... |   .|. .| . .|   | 
pdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqy
PTPc_DSPc_SM00012 1326-1414 2.7e-20 67.9 In-house 1-96 (105) alignment 
Range on Protein: 1326-1414
Range on HMM: 1-96/105.0
TVTHYQHVKWPDRDTPKTHVDTFELMELVKKSEN------PIVVHCSAGIGRTTAFIGTEYLAREVEND-PKIELTEALKHLREHRWKGVQMRSQL
||.||.. .|||  .|..  . .||.. |||..|      |.|||||||.|||  |.  ..| . .|.   .... . .|.||..| . ||.  | 
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
0048076 (Phosphotyrosine protein) phosphatases II 1317-1418 4.2e-20 67.3 In-house 37-136 (145) alignment 
Range on Protein: 1317-1418
Range on HMM: 37-136/145.0
DTTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS---ENPIVVHCSAGIGRTTAFIGTEYLARevendPKIELTEALKHLREHRWKGVQMRSQ
 .. ... .....|... |||...|  . .  |..|....    ..|..||||||.|||.....   . .      .. | |||...|..|...|.  .|
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

LYWMT
|... 
lrfly
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1207-1379 3e-19 63.8 In-house 58-247 (301) alignment 
Range on Protein: 1207-1379
Range on HMM: 58-247/301.0
PLTAVEVMDNGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQ----L
 |.  . .|  .|  | |..|    . ..|||.|||...|  ||| . . . . .| |..   |.  .||  |. .   .. . | |..| .. |     
ilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdf

ILR-----------DNVIERKLLVKDTTgkfEPKTVTHYQHVKWPDRDT---PKTHVDTFE--LMELVKKSENPIVVHCSAGIGRTTAFIGTE
..|           .. ||||. || .    ....|. .| ..||.      |.| .   .  ..   | .  |.|||||....|.  ..  .
virqlnvkiqdgsnngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvs
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1211-1424 4.8e-19 63.0 In-house 64-234 (392) alignment 
Range on Protein: 1211-1424
Range on HMM: 64-234/392.0
VEVMD-NGKRVPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNvkkcavyfasdppskldigrfqittqsrqlilrdnvi
.||.|   ..  . | .||.    . .||.|||   . .||| |   .||  |||.    | .                                     
leviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....................................

erkllvkdtTGKfEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRW
          |. . .||. .. ..|||.| ||     ..... ||        |...|||||.|||   |  . .    ..   ... . .  .|..| 
.........kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrp

KGVQMRSQlYWMTLGAVYR
  || . | | .  |||  
ymvqtkeq.yafiygavle
subfamily_egg_pd Subfamily egg 1180-1446 1.1e-18 61.9 In-house 26-287 (307) alignment 
Range on Protein: 1180-1446
Range on HMM: 26-287/307.0
TLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEV-MDNGKRV--PIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKnvKKC
. |. ..|...   ...| |   |.||  . |.. . .|. .   |||| .  .     || .| || || .||| |    .|. | ||  ..|   ..|
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

AVYFASDPPSKLDI--GRFQITTQSRQLIlRDNVIE-RKLLVkdTTGKFEPKTVTHYQhvkWPDRDTPKTHvDTFELMELVKKSENPIVVHCSAGIGRTT
  |.   .   | .  | ..|..   .    | .    || .    |. | . . |.|   .  . . . .   .... ....  .|.||..  |. ...
eyywpkaesdslvtvpGslrienlkvdsk.adplfrvtklkl..vGgddeerflehwq...gdvnnssdvy.splrvlrklrnlskpvvvqdilGvskaa

AFIGTEYLAREVENDP--KIELTEALKHLREHRWKGVQmrSQLYWMTlgaVYRLIRE-YNFNMRMHTDLMKDFDRV
...  |    ..   |  |  . .| . || .|   |.  | | ..    ||||.   .   .    .|  |..| 
tlvaieiallsllrGpitkslvlravvflrlrrrlsve..svllylf...vyrlvlfffrdvigsakeldvdyerw
0048179 (Phosphotyrosine protein) phosphatases II 1318-1417 1.3e-18 62.6 In-house 40-137 (144) alignment 
Range on Protein: 1318-1417
Range on HMM: 40-137/144.0
TTGKFEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS---ENPIVVHCSAGIGRTTAFIGTEYLArevenDPKIELTEALKHLREHRWKGVQMRSQL
    |. .....|.|. |||...|    .  |..|....    ..|..||||||.|||....    .        .. | |||...|..|. .|. ..||
yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgql

YWM
...
rfL
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1180-1414 5.8e-18 59.9 In-house 19-248 (267) alignment 
Range on Protein: 1180-1414
Range on HMM: 19-248/267.0
TLDKDNMTKSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKRvPIHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAvy
. .. ....|..   ....|.| .     | | . .. .   | | .. ..   . ||.||.||.||  ||. .   ..|  | .|    . |...    
sdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee.yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfw..

fasdPPSKLDIGRFQITTQSRQLILRDNVIerKLLVKDTTGKFE-PKTVTHYQHVKWPDRDTPKTHVDT-FELM--ELVKKSENPIVVHCSAGIGRTTAF
    ||   .  ..|  |  . |   .|    .... .   | |  . || | . ||      | ..   | ..  . ... ..|.||.||.|.||. .|
....PPkmgqakkyqdltvehslekeendy..qiitlelkfknesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtf

IGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
.  .   . . ..   .. . |...|. |   |. . . 
lvidsqleraktegvsdifdflrkirsqriglvdtkery
subfamily_CG7180_pd Subfamily CG7180 1222-1414 3.1e-17 57.2 In-house 73-279 (296) alignment 
Range on Protein: 1222-1414
Range on HMM: 73-279/296.0
IHANWIPTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVkKCAVYFASDPpsKLDIGRFQITTQSR----QLILRDNVIERK---LL
| | .. .. ... .| |..| ..| ..|| .   .... . .|. . . .  ..  |.  .   | . | . . . .     .|  |   . .|   | 
inavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalt

VKDTTGKFEPKTVTHYQHVKWPD-RDTPKTHVDTFELM---ELVKK-S-----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHR
 ...  | | ..|...|  .|.     |       ||.   .|...       |.|.||..| | .|. .... .     ||.. .... ||.| ||..|
eqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsR

WKGVQMRSQL
 . |..  . 
pqLvenveeY
subfamily_ptpA1_pd Subfamily ptpA1 1220-1379 6.6e-17 56.3 In-house 76-250 (418) alignment 
Range on Protein: 1220-1379
Range on HMM: 76-250/418.0
VPIHANWIPThGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASD----PPSKLDIGRFQITTQSRQLILRDNVIERKLLV
  | ||.|    .|..||.||||| ||  ||| |     .  | ||  . |.   ||  |.  .      |    |   . | | .|.   .  ||... 
dyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiit

KDTTGKFEPKT--VTHYQHVKWPDRDTPKtHVDTF-ELMELV--------KKS--ENPIVVHCSAGIGRTTAFIGTE
..    || .|  .|.||.  |||.. |  | . | .|.  .          |  . ||.||||||.||| .|  . 
rnirltfegetrditqyqyegwpdhnipd.htqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1222-1347 2.5e-14 47.8 In-house 62-188 (297) alignment 
Range on Protein: 1222-1347
Range on HMM: 62-188/297.0
IHANWI--PTHGHPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRQLILRDNVIERKLLVKDTt
| |...  |   .. ..| .||||..| .||| . . ..|  |.|..   |   .||| |. |    .|  | . .   |.     |.||  .| .    
inadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr.

gkFEPKTVTHYQHVKWPDRDTPKT--HVDT
   | . |.| |.. |||   |     .. 
..sesrvvrhvqflswpdhGvpsdledlvr
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1234-1404 5.6e-14 46.8 In-house 5-183 (199) alignment 
Range on Protein: 1234-1404
Range on HMM: 5-183/199.0
HRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNvEKNVK-KCAVYFASDPPSKLDIGRFQITTQSRQlILRDNVIERKLLVKDTTGKFEPKTVTHYQH
.|.|||| || .|  ||| |       .| |.  . .|| .   ..|...   .    | . .||..      | .|   .|...||     . ..||| 
rryiatqhplretmadfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqf

VKWPDRDTPKTHVD-TF--ELMELVKKSE----NPIVVHCSAGIGRTTAFIGTEYLAREVEND--PKIELTEALKHLREHR
  | .. ||.  .   |     |. || |     |..|||| | | |  |.  .   |  |.     ..| |  | ||. |
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1234-1404 7.2e-14 46.4 In-house 4-182 (198) alignment 
Range on Protein: 1234-1404
Range on HMM: 4-182/198.0
HRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNvEKNVK-KCAVYFASDPPSKLDIGRFQITTQSRQlILRDNVIERKLLVKDTTGKFEPKTVTHYQH
.|.|||| || .|  ||| |       .| |.  . .|| .   ..|...   .    | . .||..      | .|   .|...||     . ..||| 
rryiatqhplretladfwqmvwetgsghivmvndd.qknkeadypfywpttesgtgkygslsvttktit.tkpdytitaliltnnttappstreishyqf

VKWPDRDTPKTHVD-TF--ELMELVKKSE----NPIVVHCSAGIGRTTAFIGTEYLAREVEND--PKIELTEALKHLREHR
  | .. ||.  .   |     |. || |     |..|||| | | |  |.  .   |  |.     ..| |  | ||. |
tswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar
subfamily_CG42327_pd Subfamily CG42327 1174-1344 1.2e-11 38.8 In-house 22-180 (319) alignment 
Range on Protein: 1174-1344
Range on HMM: 22-180/319.0
DQVYVTTLDKDNMTKSlgylhkdkhrydgVPCKP--LTAVEVMDNGKRVPIHANWIPTHG-HPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVE
|.| ||. ||... ..             ||  .   .  .. |. |   ..|...  .   |  .||.| .|...  ||| .    .   |  |.   |
devPvtskdksrvinv.............vPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlse

KNVKKCAVYFASD--PPSKLDIGRFQITTQSRQLilRDNVIERKLLVKDTTGKfEPKTVTHYQHvKWPDRDTPKTH
. .|.|| |. .    ...   | ...| . |.   .|. .   ||.|   .. | . .||| . ||.. . |  .
lGikvcaeylPtketldntslyGdilvtlkgrev..kdryaistlllkrvdke.esrelthywy.kwleaevPaee
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1234-1282 1.3e-10 35.6 In-house 104-152 (350) alignment 
Range on Protein: 1234-1282
Range on HMM: 104-152/350.0
HRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAS
...||||.|| .| .||. ...  .|  | .|  .|| |..||  |.  
fkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqe
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1188-1429 8.7e-10 32.7 In-house 41-278 (303) alignment 
Range on Protein: 1188-1429
Range on HMM: 41-278/303.0
KSLGYLHKDKHRYDGVPCKPLTAVEVMDNGKrvpIHANWIPTHGHpHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSK
|       || |.  | |   . |.. |      |||...  . . .. | || ||  |. ||| | .  .|  . .|  . | .     . |  .    
knqfvknmdknrfvdvicldhskvklsdssy...ihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdfl

LDIGRFQITTQSRQLILRDNVIERKLLVKDTTGkfepKTVTHYQHV-KWPDRDTPKT-----HVDTFELMELVKKS--ENPIVVHCSAGIGRTTAFI--G
    |.    . ... | |    . | | . .     |.  | .|  .||  . |         . ..|  ...|    .| |    .| ||. .|    
kfeersirvgefkrvelgdgwvlkvlsvsngdy....ksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfe

TEYLAREVEnDPKIELTEALKHLREHRWKGVQMRSQLywmtlGAVYRLIREY
| .|.   | .. ..|   |. .|. | . ||  ||.       || |. |.
tahlslhse.qasldlvkclenvrngrlhavqnlsqf.....svvytllaeh
subfamily_eak_pd Subfamily eak 1235-1363 8.9e-10 32.5 In-house 94-216 (332) alignment 
Range on Protein: 1235-1363
Range on HMM: 94-216/332.0
RFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFASDPPSKLDIGRFQITTQSRqlILRDNVIERKLLVKDTTgkfEPKTVTHYQHVK
..| |  . ..    || | .  .   | .|  .||....|   ||  .   .|. | .......   . |...  |.| ..      | . | ||.   
kyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildverkef..vkrniletrllelskGn...ethrvlhykvfG

WPDRDTPKTHvDTFELMELVKKSENPIVV
| . ..|| . | . | . .|.   . ..
wtettlpkye.dflalrkvmkevGvllli
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1322-1416 1.9e-09 31.4 In-house 86-185 (440) alignment 
Range on Protein: 1322-1416
Range on HMM: 86-185/440.0
FEPKTVTHYQHVKWPDRDTPKTHVDTFELMELVKKS-----ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
 | .|. .|..  |||.  ||     ..... |..|     . |..|||||| |||   |  . . ||..   .|..   .. .|. | . ||   |  .
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf
PTEN_1 1329-1416 4.8e-09 31.3 In-house 96-184 (196) alignment 
Range on Protein: 1329-1416
Range on HMM: 96-184/196.0
HYQHVKWPDRDTPKTHVDTFELMELVKK-----SENPIVVHCSAGIGRTtAFIGTEYLAREVEndpkIELTEALKHLREHRWKGV-QMRSQLYW
 | |. ..|  .|  .    .. ..        ..| ..||| ||.||. ...   || .           |||...||.|..|  ...||  .
eylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRs.GtvvaayLmykgk....ltadeAlelvrekRppgapnspsqerl
0038934 (Phosphotyrosine protein) phosphatases II 1326-1419 1.3e-08 30.2 In-house 78-169 (194) alignment 
Range on Protein: 1326-1419
Range on HMM: 78-169/194.0
TVTHYQHVKWPDRDTPKTHVDTFELMELV-----KKSENPIVVHCSAGIGRTTAFIGTeYLAREVendpKIELTEALKHLREHRWKGVqmRSQLYWMTL
   .| .  .||. |. .   ... ..||     ..... ..||| ||.|||  ...  ||        .. . ||....|| | ...  ..| |.  |
agieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa.YLiyrl....gmsaeeAialfrekRpgai..pnqdyleal
subfamily_CG42327_pd Subfamily CG42327 1355-1416 3.4e-07 24.2 In-house 244-306 (319) alignment 
Range on Protein: 1355-1416
Range on HMM: 244-306/319.0
KKSENPIVVHCSAGIGRTTAFIGTEYLAREVEND-PKIELTEALKHLREHRWKGVQMRSQLYW
..|  |.||||| |.|||   | ..   |..|.    ... . . ..|. | . |. . |  .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef
subfamily_PTPDC1_pd Subfamily PTPDC1 1322-1415 6.5e-07 24.0 In-house 78-166 (182) alignment 
Range on Protein: 1322-1415
Range on HMM: 78-166/182.0
FEPKTVTHYQhVKWPDRDT--PKTHVDTFELMELVKKSEnPIVVHCSAGIGRTTAFIGTeYLAREVendpKIELTEALKHLREHRWKGVQMRSQLY
.  . ...|. . |.| ..   .. .|   ... . . .  . ||| || |||   | . ||        ...  .|.| .|..| | .| |.|. 
lmeqgiyvyn.fgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliac.ylvyak....rltaekaiklvrskrpksiqtreqve
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1353-1386 1.2e-06 22.5 In-house 257-290 (350) alignment 
Range on Protein: 1353-1386
Range on HMM: 257-290/350.0
LVKKSENPIVVHCSAGIGRTTAFIGTEYLAREVE
| ..  .||.||||||.|||  ..  ..|  ..|
ldnarsspilvhCsaGvGrtGtlvtlDsllsdfe
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1232-1282 1.5e-06 21.8 In-house 105-155 (349) alignment 
Range on Protein: 1232-1282
Range on HMM: 105-155/349.0
HPHRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLCLNVEKNVKKCAVYFAS
  ...|||| ||  | .||. . .  .|  .  |  . |....|| .|.  
vekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1358-1414 3.1e-06 21.3 In-house 228-284 (297) alignment 
Range on Protein: 1358-1414
Range on HMM: 228-284/297.0
ENPIVVHCSAGIGRTTAFIGTEYLAREVENDPKIELTEALKHLREHRWKGVQMRSQL
. ...||||||.||.   . .. ..  . ..   . .  |..||| | . ||   | 
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqf
Borrelia_P83 Borrelia P83/100 protein 975-1151 4.1e-06 11.6 Pfam-A 194-338 (489) alignment 
Range on Protein: 975-1151
Range on HMM: 194-338/489.0
VNKRKEPVDFptlavviplvamllagvaiggflfrqhkiheKDREEEKKRKTQDfQDQQDADIERAEADEQRRKMNVERAKKDEERAKKDKRDAEERRKK
|..|.. ||                                |.|| ... | .. . ....| .  .||....|... ... | .| .  ..  |... .
velrrdivDl...............................keresqedakraq.vlkeeldkkqkdadkakkkadtaednadkqrkevreklqeaknlp

DEERAKKDKEDAKKAKEDQEKIDKLAAEVKEREEKSLARHEKEEEDEKRRLKEEEDVKQLNKERAMEREEQLIGDMK
.. . .. ||| | |.| . .|.|   |.|...|. .  .... || |.  |.||   .  .. | .  |.. .|..
epadvsskkedkkvaeekkreiekaqkeikkkdeeakkakdakaedlkkeskaeekeaedkeleakkereevaeDlq
subfamily_PTEN_pd Subfamily PTEN 1354-1416 4.6e-06 21.7 In-house 110-171 (184) alignment 
Range on Protein: 1354-1416
Range on HMM: 110-171/184.0
VKKSENPIVVHCSAGIGRTTAFIGTeYLAREVENDPKIELTEALKHLREHRWKGVQMRSQLYW
 ....| .|||| || |||   | . ||  .   . . | .|  .. | .  |||.. ||. .
eedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRY
PTPc_motif_SM00404 1346-1410 6e-06 21.2 In-house 68-126 (140) alignment 
Range on Protein: 1346-1410
Range on HMM: 68-126/140.0
DTFELMELVKKSENPIVVHCSAGIGRTTAFIGTEYLAREvendpKIELTEALKHLREHRwKGVQM
 . . .| ..|..  ..||| ||. |. ..|  ... ..     ...| ||.. ..| | . .. 
kvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr.....qlslaeayefvkerR.piisp
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1234-1295 8.1e-06 19.4 In-house 236-293 (440) alignment 
Range on Protein: 1234-1295
Range on HMM: 236-293/440.0
HRFIATQGPLDNTCEDFWAMCVYHNVDKIAMLclNvEKNVKKCAVYFASDPPSkLDIGRFQI
  ||||| ||| |  ||| .   ...  | ||  | . | | |..|.  .  | . .| | .
nafiatqmpldstvldfwrlvhdyristiiml..n.qlndktcsiywpvntrs.vtfgpftv