Gene Y18H1A.1 in Caenorhabditis elegans

Synonym: CELE_Y18H1A.1, Y18H1A.1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf4
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP208_AA protein Get Run
CeleP208_AA_168-436 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 161-450 7.6e-124 407.0 In-house 3-300 (302) alignment 
Range on Protein: 161-450
Range on HMM: 3-300/302.0
LTGGADKWVGEAVAKNWMDSIDTAEVKKEYDKLQSQKIDVEKdCKTWKSNPKFNQSEDFPALDSNLVKLG---KDYVNISLVDVP-LGRNVHLGQAPVTN
.. ...|||.|..||....|.||||||||..|....|.|.|| ||..|.|.|.|||||.|.||||||||.   ..|||.| |.|| |.|...|.| |...
veeekekWveeeeakklvksldtaevkkefkkidtmkvdlek.CkafkknlkknqsedvpildsnlvkleaepdsyvnaskvevPeltrsiilaQlpkvd

TE---ETFWKAVFDKRITHIDLLVGDETI-----EFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQA
.|   |.||..||...|.....|||.|..     |.||||..||..||.|..|||.||.......|..|||.|.|||||...||.|..|||...|| |.|
sedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya

IAIKEALGLnyFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGDKK
 .||.| ..  | .|..|||...||| .||||||.||.|||||...... .||.|..|||||||||||||||..||.||||.||..||||||||.|..||
eliktaakv..fakkikadentvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkkk

PT
 .
ee
0036941 (Phosphotyrosine protein) phosphatases II 174-444 1.2e-47 158.0 In-house 3-286 (297) alignment 
Range on Protein: 174-444
Range on HMM: 3-286/297.0
AKNWMDSIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGKD---YVNISLVDVPL-GRNVHLGQAPVTNTEETFWKAVFDKR
.| .......| ..||...|.. ... ....  .. | . |.. |....|.. |||...   |.| |.||..  .|.  . |.|  || | ||. |.. .
lkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

ITHIDLLVGDETIEF------FPKKAEDYTNYGQMWINNRRVEYV-NDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLL
.|.|  |. ..  ..      .| . ... .||........||.| .||. .. .||...|...| ....  . .|  . ||   |. ..    .. .| 
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

KAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDT--KLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAE
..| ..  .. .  | ||.| |.|. .... ...  |  ...| ..||..|.||| || .. ||. ||  ||...||| ||.  
llpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl
0040438 (Phosphotyrosine protein) phosphatases II 167-453 5.7e-47 155.9 In-house 1-294 (317) alignment 
Range on Protein: 167-453
Range on HMM: 1-294/317.0
KWVGEAVAKNWMDSIDTAEVKKEYDKLQSQKIDvEKDCKTWKSNPKFNQSEDFPALDSNLVKLG-------KDYVNISLVDVPL-GRNVHLGQAPVTNTE
|....  | ....  |   ...|. .|.|.|.| . ..  .. |...|.. |.. .|.. |||         ||.| |.||.|  .|.  . |.|  || 
kvldlllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntv

ETFWKAVFDKRITHIDLLVGDE------TIEFFPKkaEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVP--LKQAIA
| ||. |.. ..|.|  |.  |        ...|   .....||....... .|. ....  . .||...|.|.| ....    .|  ..||  ... ..
edFwrmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

IKEALGLNYfllKaPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLaEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTKPAEGDKKPT
. ||.  ..   . . ..  .. .  | ||.|.|.|. .... ....  .... ..|| .|.||| || .. ||. ||  ||...|.|.|..   ..|  
fleavreal...e.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklk

LSN
| .
llk
0050432 (Phosphotyrosine protein) phosphatases II 165-441 3.7e-45 150.0 In-house 23-305 (308) alignment 
Range on Protein: 165-441
Range on HMM: 23-305/308.0
ADKWVGEAVAKNWMDSIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKL--GKDYVNISLVDVP---LGRNVHLGQAPVTNTEE
  |.  . ..| ... .|.  ...|. .|.|.|.. | ..  .. | ..|.. |....|.. |||  | ||.| |.||..   | |   . |.|  || |
slklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssklprkfIatqgPlpntve

TFWKAVFDKRITHIDLLVGDET------IEFFPKKAE-DYTNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKqaiaIK
 ||. |.. ....|  |   .        ...| . . ....||.........|  .||. .. .|....|...|.....    ||. . || .    ..
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhytnWpdhgvPps....pe

EALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTK
. | .  .. |   ..  .. .  | ||.| |.|| .... ....  .. . ..|| .|.||| .| .. ||. ||  ||...|.|.||
illdflelvrkslpggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltk
0043336 (Phosphotyrosine protein) phosphatases II 168-435 1.6e-43 144.5 In-house 4-277 (278) alignment 
Range on Protein: 168-435
Range on HMM: 4-277/278.0
WVGEAVAKNWMDSIDTAEVKKEYDKLQSQKIdVEKDCKTWKSNPKFNQSEDFPALDSNLVKLG-------KDYVNISLVDVPL-GRNVHLGQAPVTNTEE
. . . | ...   . . ...|. .|.|.|.  ....  .. | ..|.. |....|...|||         ||.| |.||..  .|.. . |.| ..|.|
vkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetve

TFWKAVFDKRITHIDLLVGDE------TIEFFPkkaEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKE
 ||. |.. ..|.|  |....        ...|   .....||.........|. .||. .. .||...|...| ....    .|  ..||   .. .. 
dFwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldf

ALGLNYFLLkaPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLaEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
   .. .|   . ..  .. .  | ||.|.|.|| .... ... . .... ..|| .|.||| || .. ||  ||  ||...
lkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyealleyl
0047943 (Phosphotyrosine protein) phosphatases II 175-435 2.8e-42 140.5 In-house 3-272 (273) alignment 
Range on Protein: 175-435
Range on HMM: 3-272/273.0
KNWMDSIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKL---GKDYVNISLVDV-PLGRNVHLGQAPVTNTEETFWKAVFDKRI
. .... ... ...|...|.|.|..... .  .. | ..|.. |....|.. |||   | ||.| |.||. .|.|.  . |.|  || | ||. |.....
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

THIDLLVGDETI------EFFPKKAED-YTNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLLK
..|  |. ..         ..| . .. ...||.........|. .||.. . .|....|...| ....    .|  . ||   .. ..    .. .| .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

APADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
.| ..  .. .  | ||.| |.|| .... . ..  .... ..|| .||||| .| ...||. ||  ||...
lpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 157-440 9.3e-41 135.6 In-house 5-294 (297) alignment 
Range on Protein: 157-440
Range on HMM: 5-294/297.0
HKSSLTGGADKWVGEAVAKNWMDSIDTAEVKKEYDKLQSQKIDveKDCKTWKSNPKFNQSEDFPALDSNLVKLG--------KDYVNISLVDVPL--GRN
....|.    ..  ..... ...  ..  ...|. .|.|.|.|  . .  .. | ..|.. |....|.. |||          ||.| |.||..   .|.
rdallesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

VHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDE-----TIEFFPKKAEdytNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSnsIICNVTVISNWKVD
. . |.| ..| | ||. |.. ..|.|  |   .       ...| . .   .||........||. .|..... .||...|.|   ....    .|  .
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg...tygdftvtllkveh.ldgytvrtlevtnnges..rtvthfqytgwpdh

TVPLKQAIAIKEALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVT
.||   .. ..    .. .| ..| ..   . .  | ||.|.|.|.  ... ....  .... ..|| .|.||| || .. ||  ||  ||...|.|.|
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0046845 (Phosphotyrosine protein) phosphatases II 186-441 1.2e-38 128.6 In-house 2-280 (284) alignment 
Range on Protein: 186-441
Range on HMM: 2-280/284.0
VKKEYDKLQSQKIDV--EKDCKTWKSNPKFNQSEDFPALDSNLVKLG--------KDYVNISLVDVP------LGRNVHLGQAPVTNTEETFWKAVFDKR
...|. .|.|.....  . ..  .. | . |.. |....|.. |||          ||.| |.||..        ..  . |.|. || | ||. |....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

ITHIDLLVGDE------TIEFFPKKaEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPHG-CSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLL
...|  | . .         ..| . ... .||.........|. .||. .. .|....| ...|.....  . .|  . ||   .. ..    .. .| 
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

KAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLA--EPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTK
. | ..  .. .  | ||.|.|.|| .. . ....    .. . ..|| .|.||| .| .. ||. .|  ||...|.|.|.
nlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0045450 (Phosphotyrosine protein) phosphatases II 184-437 2e-38 128.2 In-house 27-306 (307) alignment 
Range on Protein: 184-437
Range on HMM: 27-306/307.0
AEVKKEYDKLQSQKI--DVEKDCKTWKSNPKFNQSEDFPALDSNLVKL--------GKDYVNISLVDVP---------LGRNVHLGQAPVTNTEETFWKA
. ..||. ||.|...    | ..  .. | ..|.. |....|.. |||        . ||.| | |.||         |.|.  . |.|  .| | ||. 
tgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrm

VFDKRITHIDLLVGDETI------EFFPKKaEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPH-GCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGL
......|.|  | ...        ...| . ... .||.........|.  |.. .. .|| .. |...|.....    .|  ..||   .....    .
lweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

NYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAE--PCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
. .| . | ..  .. .  | ||.|.|.|. ..   ...      ... ..|| .|.||| || .. ||. ||  ||....|
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelllk
0051299 (Phosphotyrosine protein) phosphatases II 183-436 4.8e-38 126.6 In-house 22-287 (288) alignment 
Range on Protein: 183-436
Range on HMM: 22-287/288.0
TAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKL-------GKDYVNISLVDV-PLGRNVHLGQAPVTNTEETFWKAVFDKRITHID
.. ...|...|.|...|..  .  .. | . |.. |....|.. |||       | ||.| |..|. .|.|   . |.|  || | ||. |.......| 
ltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIv

LLVGDE------TIEFFPKkaEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPH----GCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLLka
 | . .         ..|   .....||.........|  .||.  . .||...    |...|.....    ||  . ||      ..    .. .|   
mltklvelgrekcaqYwpl..ggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala..

PADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
. .   .. .  | ||.| |.|| .... ....  .. . ..|| .|.||| .| ...||  .|  ||...|
sgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
0040439 (Phosphotyrosine protein) phosphatases II 202-437 5.9e-36 119.7 In-house 3-248 (249) alignment 
Range on Protein: 202-437
Range on HMM: 3-248/249.0
KDCKTWKSNPKFNQSEDFPALDSNLVKLGK-------DYVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDETI------EFFPK
...  .. |.. |.. |....|.. |||.        ||.| |..|..  .|.. . |.| ..| | ||. ... .||.|  |  ..        ...| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

kaEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLAL
  .....||........||. .||.... .|........|. ...  . .|  . ||   .....    .. .| ..| ..  .. .  | ||.|.|.|.
..ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

AVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
  ... ....  . .. ..|| .||||| || .. ||. ||  ||....|
ylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyeallelllk
DSPc_SM00195 186-436 3.7e-34 113.6 In-house 2-263 (263) alignment 
Range on Protein: 186-436
Range on HMM: 2-263/263.0
VKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGK-------DYVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLV
.|.|..||.... . |.... .|.| . |......  |.. ||| |       ||.| . ....   ... . |.|  .| | ||. |...... |  |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GDET------IEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVP--LKQAIAIKEALGL----Nyfllkap
 .|.       ...|.........|.. .....|| ..|.. .  .|.  .|....  ...  . ||.   ||   |. ... .|.      .       
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

aDEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 ..  ....  | ||.| |... .... ....   . | .|||..|.|||..|... ||  .|  .|..||
.sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 186-436 3.7e-34 113.6 In-house 2-263 (263) alignment 
Range on Protein: 186-436
Range on HMM: 2-263/263.0
VKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGK-------DYVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLV
.|.|..||.... . |.... .|.| . |......  |.. ||| |       ||.| . ....   ... . |.|  .| | ||. |...... |  |.
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

GDET------IEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVP--LKQAIAIKEALGL----Nyfllkap
 .|.       ...|.........|.. .....|| ..|.. .  .|.  .|....  ...  . ||.   ||   |. ... .|.      .       
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

aDEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 ..  ....  | ||.| |... .... ....   . | .|||..|.|||..|... ||  .|  .|..||
.sgpivVhCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
0042113 (Phosphotyrosine protein) phosphatases II 203-436 4.6e-34 113.3 In-house 2-244 (245) alignment 
Range on Protein: 203-436
Range on HMM: 2-244/245.0
DCKTWKSNPKFNQSEDFPALDSNLVKLG-------KDYVNISLVDVPL-GRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDE------TIEFFPKk
..  .. |...|...|....|...|||         ||.| |.||..   ... ..|.| ..| | ||. ... .||.|  |  .|        ...|  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

aEDYTNYGQMWINNRRVEYvNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLLKaPADEHAMIVSPRGAGRAGYFLALA
 .....||.........|. .||.... .||...|.. |  ...    .|  ..||   .. ..    .. .| . ....  .. .  | ||.|.|.|. 
.gesltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaGvgRtGtfiaay

VAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
 ... ...   . .. ..|| .||||| || .. ||  ||  ||...|
lmleqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
Y_phosphatase Protein-tyrosine phosphatase 210-431 2.8e-33 110.7 Pfam-A 1-233 (235) alignment 
Range on Protein: 210-431
Range on HMM: 1-233/235.0
NPKFNQSEDFPALDSNLVKL----G-KDYVNISLVD-VPLGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDETI------EFFPKKAEDYTNYGQ
| | |...|... |.. |||    | .||.| . |.  .  ... . |.|. .| | ||. |...... | .|. .|        ...|.. |....||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MWINNRrVEYV-NDDVYRFAIEVVPHGCSNS---IIcNVTVISNWKVDTVP--LKQAIAIKEALGLNYfllkAPADEHAMIVSPRGAGRAGYFLALAVAV
. .... ..   ... | .    . . ...|   .. ..  . ||.  .||   |. . . ...  .     .. ..  ....  |.||.| |.|| ...
ikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldill

NTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISL
. ....   . . .|||..|.||| .|.|. ||. ||  .
eqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 210-431 2.8e-33 110.7 In-house 1-233 (235) alignment 
Range on Protein: 210-431
Range on HMM: 1-233/235.0
NPKFNQSEDFPALDSNLVKL----G-KDYVNISLVD-VPLGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDETI------EFFPKKAEDYTNYGQ
| | |...|... |.. |||    | .||.| . |.  .  ... . |.|. .| | ||. |...... | .|. .|        ...|.. |....||.
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

MWINNRrVEYV-NDDVYRFAIEVVPHGCSNS---IIcNVTVISNWKVDTVP--LKQAIAIKEALGLNYfllkAPADEHAMIVSPRGAGRAGYFLALAVAV
. .... ..   ... | .    . . ...|   .. ..  . ||.  .||   |. . . ...  .     .. ..  ....  |.||.| |.|| ...
ikvelk.ekekedekeytlrklelkkkkeesekrev.kqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldill

NTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISL
. ....   . . .|||..|.||| .|.|. ||. ||  .
eqleaeee.vdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 256-461 2e-29 96.3 In-house 129-329 (346) alignment 
Range on Protein: 256-461
Range on HMM: 129-329/346.0
NTEETFWKAVFDKRITHIDLLVGDE-----TIEFFPKKAEDYTNYGQMWINNRRVEyVNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIA
   | ||  .....|  . |.| |.     |  .|  .   |   |.|.||||| . |  |   ..|||.| | |.|.||.|   . ||    | |    
sfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrrad.vsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpi

IKEalgLNYFLL-KAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLaEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKvtkpAEGDKKP
||    .  ||  |   .    .||  |.|||  |.    |.| ..  . || | .|.|.|. ||| .|.|| ||.|.|  .. .| .|      | |.|
ikm...ihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngi.epniceimknikqqrpggvesfaqyasiyaivfdyiark....rggkkap

TlsNKYIYKKSV
   ||.| .   
v..nkdinrfid
0045098 (Phosphotyrosine protein) phosphatases II 189-437 9.4e-22 73.1 In-house 12-274 (278) alignment 
Range on Protein: 189-437
Range on HMM: 12-274/278.0
EYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKlgkDYVNISLVDVPlGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDETI------
|.. | .. |  |  .  . .| ..|   |....|.. ||   ||.| |..|.. ...  . |.|  .| . ||. ... .||.|  | . .        
efefllllgipseitpalylgnldknRykdilpydhsrVk...dYINAsyidgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

EFFPKkaEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPH---GCSNSIICNVTVISNWKVDTVPLKQA-IAIKEALGLNYFLLK------------APA
...|   ... .||......  .|...| ..|. . .  .       |   ..  . .|   .||       . |.|      ||             . 
qywpe..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

DEHAMIVSPRGAGRAGYFLALAVAVNTIdtKlAEPCIADIVKSIRSQRPR-AVDSFCQYCSLYISLLYFIKK
..   .    | ||.| . |.      .  .    .. ..|| .|||||  || .. ||  ||  ||.....
ggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 177-438 9e-20 65.9 In-house 14-282 (288) alignment 
Range on Protein: 177-438
Range on HMM: 14-282/288.0
WMDSIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGK-------DYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDK
 ..  . .....||..| . . . ...      | | |. ..  ..| . ||| |       ||.| | .|.  ......  |.|...| . ||. |...
kksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyen

RITHI---DLL-VGDE-T-IEFFPKkAEDYTNYGQMWINNRRVEYVNDDVYRfAIEVVpHGCSNSIICNVTvISNWKVDTVPLKQAiaikEALGLNYFL-
... |     |  |.. . .|..|. |.. .|||.. .  . .. ..| | |  .... .  ..  | .      |  . ||  .|    . |.| . . 
ktstivmltelveggktkCeeYWPd.adkpknyGsvtvtlveskeledfvlr.kllle.kkkteleitqyq.ylaWpdhgvPeska....pllellrqvk

LKAPADEHAMI-VSPRGAGRAGYFLALAVAVNTIDTkLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
   .||   .| .   | ||.| |.||  .......      .|..|. .| ||.  |.   ||  .|  ||  |...
vanqadtgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 181-435 2.6e-16 54.7 In-house 24-290 (298) alignment 
Range on Protein: 181-435
Range on HMM: 24-290/298.0
IDTAEVKKEYDKLQSQKIDVEKDCK---TWKSNPKFNQSEDFPALDSNLVKLGK-------DYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKR
 . .  ..|. .|.| . ..|...|     ..| | |   |  ||||  | | |       ||.| | ..   ||| ..  |||.|.| | ||. | .. 
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteed

ITHIDLLVGD------ETIEFFPKKAEdyTNYGQMWINNRRVEYVnDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYflLK
|. | .|         .  ...|.. .  ..||.. .. .. |    |.    ..|  .  ...        ..|   .|| ..   ..     .    .
igtiVmltnleeldktkyhkywPdegk..etygeitvsllskeef.adlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra..sq

APADEHAMIVSP-RGAGRAGYFLALAVAVNTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
  | ....||    | ||.| | |.   .. . ..     . ..|| .| .|| ||..  ||  .|   | ..
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqv.vDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 187-438 1e-14 49.3 In-house 18-279 (281) alignment 
Range on Protein: 187-438
Range on HMM: 18-279/281.0
KKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKL-------GKDYVNISLVDVPLGRN-VHLGQAPVTNTEETFWKAVFDKRITHIDLLVG
..||.||..  .|      . . | . |.  .  | |   ||.         ||.| . |.   | .     |.|| .. ..||. |...... | ..  
ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtr

D---ETI---EFFPkKAEDYTNYGQMWINNRRVEYVNDDVYRfAIEVVPHGCSNSIICNVTViSNWKVDTVPLKQAiaikEALGLNYFL--LKAPADEHA
.   . .    ..|   .  ..||.. ... . |  .  . |  ...  ... .  . ...   .|    || . .    | |.    .  |. .  ...
eieagklkChrYWP.ddnselkygdvtvkstaeeekatyier.kfkleresgetreveqlay.taWPdhGvPattk....ellefrkevlkltekktkap

MIV-SPRGAGRAGYFLALAVAVNTIDTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
...    | ||.| ..||  .|......|.|  . ..|...| .|   | .  ||  .|  .|  ..|.
lvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN13_pd Subfamily PTPN13 179-436 3.5e-14 47.7 In-house 6-270 (273) alignment 
Range on Protein: 179-436
Range on HMM: 6-270/273.0
DSIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGKD--YVNISLVDVPLGRNVH---LGQAPVTNTEETFWKAVFDKRITHI
. .|  . ..|...|.  |   . .    |.| . |.  .    |   ||||..  |.| ||. ||.| . .   . | |. .| . ||. |.... . |
kkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

DLLVGDET---I---EFFPKKAEDYTN-YGQMWINNRRVEYVNDDVYRfAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFllKApa
 ..  .     .    ..|..... .  .... ... .|.  .. | | |..|     ..|.        .|    || . |  .. .  .. .  .   
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvr.alavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrl..qt..

DEHAMIVS-PRGAGRAGYFLALAVAVNTIDTKLaEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
|.  ..|    | ||.| .... |... |. .  |  . .||...| ||   | .  ||   | ..|. .|
dagPivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 182-437 7.3e-14 46.5 In-house 21-285 (319) alignment 
Range on Protein: 182-437
Range on HMM: 21-285/319.0
DTAEVKKEYDKLQSQKIDVEKDCKTwKSNPKFNQSEDFPALDSNLVKL-------GKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHI
 .  ..||. .|.  . |  . ... . | | |. ..  | |   |.|       | ||.| | .|    |. ..  |||. || | ||. |.....  .
getllekefkllkeavndtfdsask.eenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessiv

DLLVGD-ETIEFFPKKAEDYTN---YGQMWINNRRVEYVNDDVY-RFAIEVVPHGCSNSIICNVtVISNWKVDTVPLKQAiAIKEALGLNYFLLKAPADE
 .| .. | .. . ||  ...|   ||.. ..    |  .| .  .. ..          . .     .|  . || |   .. . |.      . . . 
vmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhf.qyteWpdhdvPekat.slldllkrirksrektqsg

HAMIVSPRGAGRAGYFLALAVAVNTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
  ..    |.|| | |..| .... .    .   .  .|. .| ||.  |.   ||  .|  || ... 
PivvhCsaGvGRtGtfivldamlervkeegv.lDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 231-432 8.7e-14 46.3 In-house 37-239 (250) alignment 
Range on Protein: 231-432
Range on HMM: 37-239/250.0
KDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLLV-----GDETIEFFPkkAEDYTNYGQMWINNRRVEYVNDDVYRfAIEVVPHGC
 ||.| | ...  .|. ..  |.|...| | ||. |... .. | .|      . .  ...|  .|  ..||.. ..    |   | . |  . .  .  
sdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywP..vekaekyGdvtvsllskeefadytkr.klklskakk

SNSIICNVTVISNWKVDTVPLKQAIAIKeaLGLNYFLLKAPADEHAMIVS-PRGAGRAGYFLALAVAVNTIDTKLaEPCIADIVKSIRSQRPRAVDSFCQ
... |       .|   .|| .   ...  |  .    .  |..  .||    | ||.| |.|.   .. . ..     . ...| .| .||.||.|  |
aderivrqlhfvvWPdkgvPevatavLe..llkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkek.vvdvfkvikvlrkdrphavesleq

YCSLYISLL
| ..|  .|
yvfvyeiil
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 182-433 1.2e-13 45.9 In-house 20-281 (305) alignment 
Range on Protein: 182-433
Range on HMM: 20-281/305.0
DTAEVKKEYDKLQSQKIDVEKDCKTwkSNPKFNQSEDFPALDSNLVKL-------GKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHI
.. .....|..|....  .. ..|.   | . |....   || . ..|        .||.| | ||   ... ..  |.|. || . ||. ... ....|
sdkgleaqykslyeeeesidvgkke..ankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

DLLV----GDE--TIEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNyFLLKAPAD
 .|.    |..     ..|..  . ...|.. .. .  . ..| . |     . .. ..|       . .|  . || . .  ..    ..    |   .
vmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvq.kdqkkdkg

EHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLY
   ...   | ||.| |.|. .|.. . .   .  .....| .||.|. .| .  || .|.  |  
vpllVhCsagvgRtGvfiavdialerlkkE.evvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 230-455 1.2e-13 46.2 In-house 52-278 (284) alignment 
Range on Protein: 230-455
Range on HMM: 52-278/284.0
GKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLLVGDETIEFFPKKAEdyTNYGQMWINNRRVEYVNDDVYRfAIEVVPHGCS--N
. ||.| | .     .. ..  | |  || . ||. ... ... | ||  |   ...|.|..   ..... ..   ||  .. | |  ||.  .|     
fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivlltkdkcsqywplkiv..ikeerfkvkvdsveeseeyvvr.dielsedgkekdi

SIICNVtVISNWKVDTVPLKQAIAIKEALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCS
  | .   .  |    ||   .  ..    ....  |    .  ..    |.||.| ...| | .. .. .     . ..|. .| ||.. |....||  
rkirqf.hflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkee.kqvdvynfvrdlrqqrntlvqdlvqykf

LYISLLY---FIKKKVTKPAEGDKKPTLSNKY
.|..||    | .  |. |        ||||.
iysalleehlfghsdvalpdfpayleelsnks
PTPc_DSPc_SM00012 336-432 1.4e-13 46.3 In-house 8-104 (105) alignment 
Range on Protein: 336-432
Range on HMM: 8-104/105.0
SNWKVDTVPLKQAIAIKEALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLL
..|.   || ..   ..    .. .  |.   .  ....  |.||.|.| ||..... ....  |..| .|||..|.|||..|... ||. ||  ||
tgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_PTPRB_pd Subfamily PTPRB 182-439 1.7e-13 45.3 In-house 23-289 (293) alignment 
Range on Protein: 182-439
Range on HMM: 23-289/293.0
DTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKL-------GKDYVNISLVDV-PLGRNVHLGQAPVTNTEETFWKAVFDKRITHI
. .....||..|.. . | .... . . | . |. ..  . | . |||       |.||.| . ..     |.    | |. .| . ||. |..|. . |
sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssii

DLLVG-----D-ETIEFFPKKAEDYtNYGQMWINNRRVEYVNDDVYR-FAIEVvphGCSNSIICNVTvISNWKVDTVPLKQAIAIKEALGLNYFLLKAPA
 .|            |..|.. |.  .||.. ..    | ..| | | ..||    . ..  . .      |    || | .  ..    ..  . |. .
vmltqlvekgkvkCeeYWPadeepv.lyGdikvtlvaeeeledwvirelkiek...ekeerkvrqyh.ftsWpdhgvPektktlldfvrtvreaiektas

DEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKV
..  ..    | ||.| |.||   ...|...     |. || ..|..|   | .  ||  .. ..| ...|| 
krPivvhCsaGvGRtGtfialdrllqaieee.dyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_CG7180_pd Subfamily CG7180 231-435 1.9e-13 44.7 In-house 70-290 (296) alignment 
Range on Protein: 231-435
Range on HMM: 70-290/296.0
KDYVNISLVDVPLGRNVH-LGQAPVTNTEETFWKAVFDKRITHIDLLVG--DET---IEFFPKKAedYTNYGQMWINNRRVE-YVNDDVYRFAIEVV--P
.||.| . ||  |  . .   .||...| . ||. |.|. |  .  |    | .    ...|.|.   ..||.. ..  ... | |   . | .      
sdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks..keqygeifveiveekqyanlkirtfkltkkiva

H------GCSNSIICNVTVISNWKV-DTVPLKQAIAIKEALGLNYFLLKA---PADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIR
          .  |. .  .  |.. | |||  .  |.     . .  |.   |  .  ..||. ||.|.| .||. .... .. .  |  . . || .|
lteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelveke.eevdvFeavktlr

SQRPRAVDSFCQYCSLYISLLYFI
 .||. |..  .|  .|  || ..
rsRpqLvenveeYkyiYdvlleav
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 230-455 3.2e-13 44.7 In-house 88-314 (319) alignment 
Range on Protein: 230-455
Range on HMM: 88-314/319.0
GKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLLVGDETIEFFPKKAEdyTNYGQMWINNRRVEYVNDDVYRfAIEVVPHGCSNS-
. ||.| | |.    .. ..  | |  || . ||. ... ... | ||  |   ...|.|..   ..... ..   ||  .. | |  ||.  .|  .  
fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivlltkdkcsqywplkiv..ikeerfkvkvdsveetaeyvvr.dielsedgkekdi

-IICNVtVISNWKVDTVPLKQaIAIKEALG-LNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYC
  | .   .  |    ||    . .   .  ....  |    .  ..    |.||.| ...| | .. .. .     . ..|. .| ||.. |... || 
rkitqf.hflGwpdvGvpdyp.sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee.kqvdvynfvrdlrqqrntlvqdlvqyk

SLYISLLY---FIKKKVTKPAEGDKKPTLSNKY
 .|..||    | .  |. |        ||||.
fiysalleehlfghsdvampdfpayleelsnks
subfamily_Ptp69D_pd Subfamily Ptp69D 185-438 3.6e-13 44.3 In-house 23-289 (307) alignment 
Range on Protein: 185-438
Range on HMM: 23-289/307.0
EVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGK-------DYVNISLVDVPLGRNV-HLGQAPVTNTEETFWKAVFDKRITHIDLL
 ..|||.||....|| .      | |   |..||  | |.. ||| |       ||.| | .     ..     |.|| .| . ||. . .. .| | .|
glakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

VGDETIEF--FPKK--AEDYTNYGQMWINNRRVEYVNDDVYRfAIEVVPHG-CSNSIICNVTVI----SNWKvD-TVPlKQAIAIKEALGLNYFLLKAPa
   .  .    .|    || ..||.. ..  . |  .| . | ...|   . .|. .  .  |.     .|| | .|| ..| .. . .   . | |   
snlteknrkkcakYWpiedevqygdilvklvseekhsdyiiR.eldvskkkeesgevedsrkvvqyhytgWk.DskvP.evargllklieqvrelykln.

DEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
    ..    |.||.| |.||.. .. . .   .  | ..|| .||||.  |.|. ||  || .|| .... 
rsPivvhCsaGvgrsgifvaldsllqqlkae.dkvdifetvkdLrsqRnllvqsleqYvflyralldyssyg
subfamily_PTPRK_pd Subfamily PTPRK 178-431 4.6e-13 43.7 In-house 16-273 (314) alignment 
Range on Protein: 178-431
Range on HMM: 16-273/314.0
MDSIDTAEVKKEYDKLQSQkidveKDCKTWKSNPKFNQSEDFPALDSNLVKL----GK---DYVNISLVDVPLGRNVH-LGQAPVTNTEETFWKAVFDKR
.   ..  .|.||. |         |.   . | . |.|.|  | |  .|.|    |    ||.| .|.|     . .   | |. .| . ||. |.|..
lkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyden

ITHIDLL---VGDE---TIEFFPkkaEDYTNYGQMWINNRRVEYVNDDVYR-FAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNyfLL
 . | .|   |       ....|   || . ||.. ..  ..|  .. | | |..| . .| ..  . .     .|    || ..   .|    ..    
casivmltelvevgrvkClkyWP...edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvk..ks

KAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAEpCIADIVKSIRSQRPRAVDSFCQYCSLYISL
... .   ..    ||||.| |.|... .. |...     .  .||..||...  |.   ||  .|  .
qeeeaGrivvhCsaGaGrtGtfiaidivldmieregvv.dvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN3_pd Subfamily PTPN3 178-425 9.6e-13 42.7 In-house 9-265 (280) alignment 
Range on Protein: 178-425
Range on HMM: 9-265/280.0
MDSIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLG---KDYVNISLVDVPLGR--NV---HLGQAPVTNTEETFWKAVFDKR
 ..... .| .....|  .| ... ..     | . |.  |  . |.  |||    .||.| . |.. .     |      | |...| . ||. |....
keglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqk

ITHIDLLVGD------ETIEFFPKkAEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPHGCSNSIICNVTVIsNWKVDTVPLKQAIAIKEALGLNYflLK
.. | .|            ...|.  || ..||.. .. .. .  .  |.|  .    .   .  | ..  . .|   .|| ..|  ..    ..   |.
sslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqyl.aWpdhgvPddsadflefvervrk..lr

APADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYC
. ..|  ..    | ||.| ...| .|.  |...  .  . |||. .| ||   |..  || 
sgkeePvvvhCsaGigrtGvlilletalalieaa.epvypldivrtmrdqramlvqtasqyk
subfamily_PTPN23_pd Subfamily PTPN23 183-436 2.1e-12 41.5 In-house 14-281 (288) alignment 
Range on Protein: 183-436
Range on HMM: 14-281/288.0
TAEVKKEYDKLQSQKI--DVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGK---DYVNISLVD--VPLGRNVHLGQAPVTNTEETFWKAVFDKRITHIDL
.....|.. .|....     .. .   | ... |.|.|    |.| ||| .   ||.| | |   .|   .    |||  .|   ||. |....   | .
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVm

LVGDETI------EFFPKKAEDYTNYGQMWINNRRVEYVNDDVyRFAIEVVPHGCSNSI-ICNVtVISNWKVDTVPL--KQAIAIKEALGLNYFLLKAPA
|.  |        ...|.. .. ...|.. .  ..|.  .  | .  ...  .. ..   .. .  . .|    ||   .. ... ..    |   . ..
llskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethv.ervlkletldadavksvshl.qltsWpelGvPasPetllqfldevesayeavqrks

DEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIK
.   ..    | ||.| |  .  ||. ....   . | ..|. .| ||   |    |.  .|   |  ..
ktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 167-434 3.2e-12 40.7 In-house 8-278 (303) alignment 
Range on Protein: 167-434
Range on HMM: 8-278/303.0
KWVGeaVAKNWMDSiDTAEVKKEYDKLQSqKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGK-DYVNISLVDVPLGRNVHLGQAPVTNTEETFWKAV
|| .  .||. .|  |.    .|..|. |  .  .   . . .| . |.  |   ||   |||    |.  | ...   ..  | | |.. |   ||. .
kwkl..lakrtlde.daniavnefekvvs.ylppsvsknqfvknmdknrfvdvicldhskvklsdssyihasyleldsskkailtqlplshtaadfwqmi

FDKRITHIDLLVGDETIEF------FPkKAEDYTNYGQMWINNRRVEYVN-DDVYRFAIEVVPHGCSNSIIcNVTVISNWKVDTVPLK-QAIAIKEALGL
 ....  . ||. |   .       || . .|. .. .  |       |.  | . . .  |  |  .|..  |    .|  ...| .  .  .|.   |
ieqkvkcvlllltdseydklggdsvfp.rnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksfl.hvhhykawphnsipsdgspkfvkqiwql

NYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYF
. .| |    . .. .|  | |||| |  .  |  .. .. |   .   .. .|  |  ||. ..|.  .|  |   
qsvlrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 231-435 7.4e-12 40.0 In-house 76-288 (325) alignment 
Range on Protein: 231-435
Range on HMM: 76-288/325.0
KDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLL-----VGDETIEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYR-FAIEVVPHG
 ||.| | .    ...| |  ||| |.| . .|. |.| | . . .|       |.   ..||.  .  ..| . .. | .| . | |.| . .  | .|
sdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkG

CSNSIicNVTVISNWK---VDTVPLKQaIAIKEALGLNYFLLKA--PADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAV
 . |.  .   .  |.   |.  |    |.| . .      ..|   |    ..    | ||.| |..|  |.. . .. ..  | . || .| .||  |
etrsv..kqfqlqswddmGvqkrpatl.isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakviee.srvdifgfvkklrkdrpsmv

DSFCQYCSLYISLLYFI
..  ||  .| .|  ..
etvdqyiliyealveay
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 182-435 7.6e-12 39.7 In-house 18-283 (290) alignment 
Range on Protein: 182-435
Range on HMM: 18-283/290.0
DTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLG-----KD----YVNISLVD-VPLGRNVHLGQAPVTNTEETFWKAVFDKRIT
 .   .... .|.| . . .   .. .|| . | ....   | | . |      ||    |.| . ..     ..  . |.||.||   ||| . ....|
gnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvt

HIDLLVG------DETIEFFPKKaeDYTNYGQMWINNRRVEYVNdDVYRFAIEVVPHGC-SNSIICNVTVISNWKVDTvPLKQAIAIKEALGLNYFLLKA
 | .|.       ..   ..|..  | ..||.. |.    | .| .  .  .||  .    .. .     |.||. .   ...  .|  ..   |   . 
iivmltniieegkvkCqqYWpds..dtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstg.kvtnpqtillvieemyktqrk

PADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
. ..  ..    . ||.. |.|.|...|   |.     . ...|| |.|.|  | .  ||  ..  .|  .
rgntsivvHCSdtvgrsavfcaaattinkcktegv.idvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 202-435 9.8e-12 39.4 In-house 39-278 (287) alignment 
Range on Protein: 202-435
Range on HMM: 39-278/287.0
KDCKTWKSNPKFNQSEDFPALDSNLVKL---GKDYVNISLVDVPLGRNVH-LGQAPVTNTEETFWKAVFDKRITHIDLLVGDE------TIEFFPKKAEd
   .  ..| . |.....   | . | |    .||.| . .|    .. . . ..|..||   ||| . |...| | .|. ..        ...|...  
vthniasqnkdknRltqilvpdnyrvllkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.

yTNYGQMWINNRRVEyVNDDVYRFAIEVVPHG-CSNSIICNVTVISNWKVDT-VPLKQAIAIkeALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAV
 . .|.  |.    | ||...    .||  ..  ..    .   | ||.    |. .|.| .   .   |   . ...   ..    . ||.. |.| |.
.vvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtill..vieemyktqrkrgntsivvhCsdtvGrsamfcaaat

AVNTIDTKLAEpCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
..|  .|  .   . ...|| | |.| .|    ||  ..  .| ..
tinkckteGvi.Dvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_PTPN12_pd Subfamily PTPN12 230-440 4.1e-11 37.3 In-house 67-282 (290) alignment 
Range on Protein: 230-440
Range on HMM: 67-282/290.0
GKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLLVGD------ETIEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRFAIEVVPH
|.||.| ...  . |.  ..  |.|...| . ||. ...|... . ..             ..|.. |. ...|.. ... . . |.||    ...|  .
gsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq

GCSNsIIcNVTVISNWKVDTVPLKQAIAIKEALGLNYFllKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAEPC--IADIVKSIRSQRPRAVDS
. |. .. .     .|    || ..   ..    .. .  .   |.  ..    | ||.|  .|.  . . . ..  ...  . |.| ..| ||. .| .
kesr.kv.yqfhYtaWPDhgvPssaksllelielvrel..qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqt

FCQYCSLYISLLYFIKKKVT
  ||  .| ... ...|...
keqyelvykavaelvqkele
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 183-433 4.5e-11 37.3 In-house 5-257 (267) alignment 
Range on Protein: 183-433
Range on HMM: 5-257/267.0
TAEVKKEYDKLQSQKIDVEK-DCKTWKSNPKFNQSEDFPALDSNLVKL---GKDYVNISLVDVPLGRNVH-LGQAPVTNTEETFWKAVFDKRITHIDLLV
  |..||.....    .  .  .   . | ..|. .|    | . | |    ..|.| | |.    .| . . | |. ||   |.. . |.... | || 
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

--G-DETIEFFPKKAEDYTNYGQMWINnRRVEYVNDDVYRFAIEVVphgCSNSIICNVTVI--SNWKVDTvplKQAIAIKEALGLNYFLLKAPADEHAMI
  . |.   |.| |  .  .| .. .. . .|  ..|    ..|.      |    |||.    .|...|   ..   .|  .|.        ..   ..
kvftdnirlfwPPkmgqakkyqdltve.hslekeendyqiitlelk...fknesahnvtlyyykkwnint...nnkpylkplfgilaknqlengnrPlvv

VSPRGAGRAGYFLALAVAVNTIDTKLAEpCIADIVKSIRSQRPRAVDSFCQYCSLYISLLY
    | ||.| || .   .. . |      | | .. |||||.  ||.  .|  .. .|  
acsdGvGrsGtflvidsqleraktegvs.difdflrkirsqriglvdtkeryiyihellae
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 197-425 8e-11 36.3 In-house 20-256 (283) alignment 
Range on Protein: 197-425
Range on HMM: 20-256/283.0
KIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKL---GKDYVNISLVDV----PLGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLV---GDETI---E
  | . |... . |...|. ..  . | . |.|    .||.| . . |      ...    |.|. .|   ||| |||..|| | .|     |. |    
vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

FFPKKAEdyTNYGQMWINNRRvEYVNDDVYRFAIEVVPHG-CSNSIICNVTVISNWkvdtVPLKQAIAIKEALGLNYFLLKAPADEHAMIV--SPRGAGR
..||.     .||.. .  |. |. ..   .  . .   . . ....     . .|    .   .   |   . .|    .    ... ||     | ||
yWPkrGs..edyGeftvtlrk.ettsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstgiGr

AGYFLALAVAVNTIDTKLAEpCIADIVKSIRSQRPRAVDSFCQYC
.. |.|....|. . |.     .  .|| .| ||. || .  || 
tavfiaasasvkdaltesvv.dvfavvkimreqrmmavqtldqyk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 186-440 8.7e-11 36.4 In-house 22-285 (318) alignment 
Range on Protein: 186-440
Range on HMM: 22-285/318.0
VKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVK-------LGKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLLV
...||..|. ..  | .   . . | . |.  .  | |.  ||        | ||.| . .|    .. ..  |||...| | ||. |...  . | .| 
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

GDE------TIEFFPKKaeDYTNYGQMWINNRRVEYVNDDVYRfAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIkEALGlNYFLLKAPADEHAM
  |         ..|.|  . ..||.. .. .    ..| | |  ..|  .....| .     . .|    || . |  . . .. .    .........
qeeergkakvhryWPsk..gsrsygklvvelkeevelsdyvlr.efkvtrteeeesrqvrqyhytsWpdegvpesgasll.dlvr.qvskaqqksgagpi

IVS-PRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVT
.|    | ||.| |.|. . .. |    |   . ..|| .|.||.  |    ||  .|  || ...   |
vvhCsaGvGrtGvfiavdillerikae.alvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdt
subfamily_PTPRA_pd Subfamily PTPRA 231-434 1.1e-10 35.9 In-house 86-294 (330) alignment 
Range on Protein: 231-434
Range on HMM: 86-294/330.0
KDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLLVG------DETIEFFPKkaEDYTNYGQMWINNRRVEY-VNDDVYRFAIEVVPH
 ||.| | .|    .. ..  | | ..| | ||. ..... . | .|        .    ..|.  |    ||.. .. . ..  |.  |  | .. .|.
sdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd..eGlvtyGnirvevedetvlvdytvrkflvqqlpd

GCSNSIICNV--TVISNWKVDTVPLKQAIAIKeALGLNYFLLKAPADehAMIV-SPRGAGRAGYFLALAVAVNTIDTKLAEpCIADIVKSIRSQRPRAVD
.. .     |       |    || .    .|  |     | .  |.  ...|    |.||.| |..|   .. . ..     . ..||..| |||. | 
atrekksrlvrqfhftswPdvGvPfepiGmlk.llkkvkklnqqsag..pivvhcsaGvGrtGtfivldavlervkaerkv.dvfefvkrlrlqrpqmvq

SFCQYCSLYISLLYF
.  ||  .|  || .
tdeqyefiykvlley
subfamily_egg_pd Subfamily egg 241-443 3.3e-10 34.1 In-house 79-278 (307) alignment 
Range on Protein: 241-443
Range on HMM: 79-278/307.0
VPLGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGD---ETIE-FFPKKAEDYTNY--GQMWINNRRVEYVNDDVYRFAIEVVpHGCSnsiiCNVTV
 ||  .  | |||. || . ||. || ... .| .|      |  | ..||  .|   .  | . |.| .|.   | ..| .   .  |       .   
kpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgd....deerf

ISNWKVDTVPLKQaiaIKEalGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVN-TIDTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLY
.  |. |   . .   .     |. . .   . . ... .  |  .|. ..|. .|.   .   .    .   |. .| .|. .|.|  .|  .|  .|.
lehwqgdvnnssd...vys..plrvlrklrnlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

FIKKKVTKPA
|..  .    
ffrdvigsak
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 228-432 6.8e-10 33.4 In-house 74-276 (315) alignment 
Range on Protein: 228-432
Range on HMM: 74-276/315.0
KLGKDYVNISLVDVPLGRNVHLG-QAPVTNTEETFWKAVFDKRITHIDLLVGdeTIEFFPKKAEDYTN-----YGQMWINnRRVEYVNDDVYRFAIEVVp
. . |||| ...|    .. ... |.| ... . ||. ||.. |..| .| .  ..|   .||| |       ||.. .  |. | ||...   .. || 
dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn..lvegekrkaekywpdkkviyGkitvt.rkseevnteytvrtlsvv.

hgcSNSIICNVT--VISNWKVDTVPlKQAIAIKEALGLNYFLLKAPAdEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAEPcIADIVKSIRSQRPRAVD
   ... | .|    .. |    || | .|.. .         .. .    ..    | ||.| |..|   .. .... |   . .... .|..| ..|.
...fgdnirevvqlhytswpdmgvp.kytiplmnlirtvkqhhtnsv.gaivvhcsaGvGrtGtfitldavldqaeaenaid.vynfitgvrqnrikmvq

SFCQYCSLYISLL
.  ||  .|  ||
vaeqyqfiydall
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 250-434 9e-10 32.6 In-house 96-278 (439) alignment 
Range on Protein: 250-434
Range on HMM: 96-278/439.0
GQAPVTNTEETFWKAVFDKRITHIDLLV-GDETIEFFPKKAEdyTNYGQMWIN-NRRVEYVNDDVYRFAIEVVP-HGCSNSIICNVTVIsNWKVDTVPLk
 |.|  .| ..||. |..|. ..|  |    |.  ..| .||  . ||.. .  .| .|  |  .  | .     ..  .  . ..  |  |    ||  
tqgpkkettddfwrlviekktvtivmltnlvesykywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyi.awpdknvpa.

QAIAIKEALG-LNYfllKAPADEHAMIV--SPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYF
||  . . |  .|        .|   .|     | ||.|  .|| .|.. . ..  .  |  ||| .| || . |...|||  .| ..|  
qashvldflrains...andkeeygpvvvhcsagvGrtGtiialdialeqlkle.nkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 180-439 9.1e-10 33.0 In-house 15-275 (288) alignment 
Range on Protein: 180-439
Range on HMM: 15-275/288.0
SIDTAEVKKEYDKlqSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLGKD---YVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDL
.|  . .||||    | .   ..  ... .||  .. |. |  |   |||  |   |..  .|      | .   |||.  | | .|| .... . .| .
qiaveglkkeyrd..spneasidiidsfianptrdryenlprcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivm

LV-----G-DETIEFFPKKAEDYTNYGQMwINNRRVEYVN-DDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEalgLNYFllkAPADE
|      | ... |.|| |  . . .|..  .  ...... | . . ..  . .   ...|  .  . .|. |.|| .    ..    |. .      ..
lcellekGkeksaeyfPsklGekarigrl.ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrl...levl...kslqk

HAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKV
  .. |  |.||.| .    .|....  .     |  .... | .| .|. .  ||  ..  .|. .  | 
PivvhssaGvGrtgtlililialeslrld.dflgirsllaklreerfkaiqtemqylyvhrcvleelllkk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 214-434 1.7e-09 31.7 In-house 41-268 (281) alignment 
Range on Protein: 214-434
Range on HMM: 41-268/281.0
NQSEDFPALDSNLVKL--------GKDYVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVG------DETIEFFPKKAEDYTNYGQM
|.  . |.||   |.|          ||.    .  | | |   | | |  .|   ||. ....  | | .|.       ..  |.||..|    .. ..
nrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdkl

WINNRRvEYVNDDVyrfaievVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLNYFLLKAPAdEHAMIVSPRGAGRAGYFLALAVAVNTIDTKL
 ..      ||  .       |      |   .  .|. |     |  |     | .      ..| .    .|    | ||.| ..|. .|...| ...
svsyed.stvnksl.......vttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirars.tppvihcsagvgrsgtlmaveialqsihshf

AEPCIADIVKSIRS-QRPRAVDSFCQYCSLYISLLYF
. | | .||  .|   |  .|... ||  ..  || |
tlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_PTPRG_pd Subfamily PTPRG 184-441 1.8e-09 31.4 In-house 19-293 (563) alignment 
Range on Protein: 184-441
Range on HMM: 19-293/563.0
AEVKKEYDKLQSQKIDVEKDCKT--WKSNPKFNQSEDFPALDSNLVKL-------GK-DYVNISLVDVPLGRNVH-LGQAPVTNTEETFWKAVFDKRITH
  ...|...|||. |. . |...   ..| . |   .  | |.  |||       .| ||.| . .|     . .   | |...| . ||. ..... . 
igfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

IDLLVG------DETIEFFPKkaEDYTNYGQMWINNRRVEYV-NDDVYRFAIEVVPHGCSNSiICNVTVISNWKVDTVPLKqAIAIKEALGLNYFLLKAP
| ..         .   ..||  ..  .||.. ..  . | .    | .. |. .     ..   .. .. ...  . | . .   ...  |..   .. 
ivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkq.cdteklvrqyhytkWPdh.gvPehslpvLifvkkssa

ADEH---AMIV-SPRGAGRAGYFLALAVAVNTIDTKLAEpCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKVTK
| ..    ..|    |.||.| ...|   .. | .. |   . ...| ||.||.  | .  ||  |.  ||  |. | |.
ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenav.nvfgflkhiraqRnflvqteEqYiflhdalleaiaskete
subfamily_PTPN6_pd Subfamily PTPN6 178-438 4.6e-09 30.7 In-house 20-300 (306) alignment 
Range on Protein: 178-438
Range on HMM: 20-300/306.0
MDSIDTAEVKKEYDKLQSQKI--DVEKDCKTWKSNPKFNQSEDFPALDSNLVKL------GKDYVNISLVD--VPLGRNVHL-GQAPVTNTEETFWKAVF
 .|.. | ...|...|| ..    ....  . ..| . |. .     | . |.|      |.||.| . ..  |.  .. ..  |  ...| . ||. |.
eeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvw

DKRITHIDLLV------GDETIEFFPKKAEDYTnYGQMWINNRRVEYVNDDVYR-FAIEVVPHGCSNSIICNVTvISNWKVDTVPLKQAIAIKEALGLNY
..  . | ..        .  . ..|.. |. . ||.. ..| . .  .| ..| . .. . .. ..  . .     .|    || ..   ..    .| 
qensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyh.fksWPdhgvpkdpgavLdfledvnr

FLLKAP-ADEHAMIVS-PRGAGRAGYFLALAVAVNTIDTKL--AEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
   .   |.. ...|    | || | |. . . ...| .|   |.  | ..|||.|.||   |    ||  .| .. ..|..|
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 205-440 5.3e-09 30.4 In-house 30-276 (285) alignment 
Range on Protein: 205-440
Range on HMM: 30-276/285.0
KTWKSNPKFNQSEDFPALDSNLVKL---GKDYVNISLVDVPLGRN--VHLGQAPVTNTEETFWKAVFDKRITHIDLLVG------DETIEFFPKKAEDYT
 ....|| .|.  |  ...   | |    .||.  | . .|   .      | |. .|   ||. .....|... .|.       ..   ..|.|  .  
tayeanpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

NYGQMWIN--NRRVEYVNDDVYRF-AIEVVPHGCSNSIICNVTVIsNWKVDTVPLKQAIAIKEalgLNYFLLKAPADEHAMIV-SPRGAGRAGYFLALAV
..|.  |   . . | .   ..   ..      .|. .  |   .  |  | .  ..|  . |   |  .. |    |. . |    | ||.  |. .  
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqv.pwwpdqlapedarpmie...lykwvkkvnpkekpicvhcsagvgrtatfvgidy

AVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLL-YFIKKKVT
|   |  .  .  . |||. .|. | .||.|. |.  ||. |. ||| . | 
atirimen.pniemldivremramrfqavqshmqflflyvvlmeyfigegvv
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 182-433 6.9e-09 30.0 In-house 17-275 (315) alignment 
Range on Protein: 182-433
Range on HMM: 17-275/315.0
DTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKfNQSEDFPALDSNLVKL-------GKDYVNISLVDV-PLGRNVHLGQAPVTNTEETFWKAVFDKRITHI
 || . .|.  |   .|  .. ...    .| |. ..   |||. |||        .||.| | .      .     |.|   . . ||. |.....| |
htalfseefhdlpdPdiyrqrvaretinfkk.nryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvtti

DLLV----GDE--TIEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRFAieVVPHGCSNSIICNvTVISNWKVDTVPLKQAIAIKEALGLNYFllkAPAD
 ..     ||      ..|..  | ...|.. ..   .|   | | |    |. .. .   . .     .|    |. ...  .|    .         .
vmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtq.fqftewPdkGvdkqtssllklikevkad...ngkk

EHAMIVS-PRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLY
|....|    |.||.| ....   |. |  .     . ..|| .|..||  | .  .|  .| ..| 
efsllvhcsaGvGrtGvvisidevvaqikrt.rsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_PTPN9_pd Subfamily PTPN9 184-437 3.6e-08 27.8 In-house 16-292 (297) alignment 
Range on Protein: 184-437
Range on HMM: 16-292/297.0
AEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLG-------KDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDL
  ..||| .......  . ..   ..| . |. .|   .|.  |.|         ||.| . ||    .. ..  | |. .| . ||. |.....  | .
rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivm

LVG------DETIEFFPKKAEDYTNYGQMWINNRRVEYVNDDVY-RFAIEVVPHGCSNSIIC-NVTVISNWKV-----DTVPLKQAIAIKEALGLNYFL-
             ...|.. |. ...|.. ..|  ||  .| .   . |. | .. | ...   ..   .. |     . . .....  | ||  ...  
ttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgd

-LKAPADEHAMIV-SPRGAGRAGYFLALAVAVNTIDTkLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
  | ....  ..|    | ||.| | .| .... ... ..   . . || .|.||  ..    ||   |...| . ..
ewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 250-437 5.4e-08 27.3 In-house 78-270 (274) alignment 
Range on Protein: 250-437
Range on HMM: 78-270/274.0
GQAPVTNTEETFWKAVFDKRITHIDLLVG-DE-----TIEFFPKKAED--YTNYGQMWINNRRVeyVNDDVYRFAIEVVPHGCSnSIICNVTVISNWKVD
 | |..|| . ||. .. .... | .|    |       ..||.. .     .||.. |... .  |. . |.    |. .  . .  .     ..|   
tqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeiserygdveikveki..verndysvrklvlkyler.ersvkhywytdWPdh

TVPLKQAIAIKEALGLNYFLLKAPADEHAMIV-SPRGAGRAGYFLALAVAVNTIDTKLAePCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKK
 .| .    ..  |  .    .. |   ...|    | ||.| |.|  .||. .. .     .  ||  .| .|   |..  ||  ..  |  . |.
ksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeiv.vdvlkivcnlrldrGGmvqtseqyelihralclylkr
0051429 (Phosphotyrosine protein) phosphatases II 231-438 6.2e-08 28.2 In-house 4-228 (272) alignment 
Range on Protein: 231-438
Range on HMM: 4-228/272.0
KDYVNISLVDVPlGR----N-VHLGQAPVTNTEETFWKAvFDKRITHIDLLVGDETIEFFP----------------KKAEDYTNYGQMWINNRRVEYVN
 .|.| . |. . ||    . . ....| ..|.. ||.   . .|..|  | ..| .....                  ..   .||.... .  .|. .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DDVYRFAIEVVPHGCSNSIICNVTVISNWKVDTVPLKQAIAIKEALGLnyfllkapaDEHAMIVSPRGAGRAGYFLALAVAVNTIDTK-------LAEPC
| ..|. . .  .. ...    . .  .|  . || .. ... |.|           ..  ..    | .| | . ||   .  ..         | . .
dyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnly

IADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKK
....|. .|.||| || .  ||  ||  || .... 
leeaveelraqrpgavqteeqylflyeallellrsl
subfamily_PTPN14_pd Subfamily PTPN14 180-302 7.7e-08 26.7 In-house 19-158 (300) alignment 
Range on Protein: 180-302
Range on HMM: 19-158/300.0
SIDTAEVKKEYDKLQSQKIDVEKDCKTWKSNPKFNQSEDFPALDSNLVKLG------KDYVNISLVDVPLGRNV---HLGQAPVTNTEETFWKAVFDKRI
 .. ..| .||.... .. | . .. . . | . |. .|.   . | |.|       ..|.| | . |..| .       |.|. .| . ||. |... .
kleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgv

THIDLLVGD------ETIEFFPKK--AEDYTNYGQMWINN
. | .|  .       ....|||.   ..  ..|.  . .
qlivmlteeeedgkeksfkyfPkleskkktvefgkfkvtt
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 231-434 9.2e-08 26.5 In-house 79-283 (297) alignment 
Range on Protein: 231-434
Range on HMM: 79-283/297.0
KDYVNISLVDVPLGRNVHlGQAPVTNTEETFWKAVFDKRITHIDLLVGDETIE-----FFPKKAedYTNYGQMWINNRRVEYVNDDVYRfAIEVVPHGCS
 |||| | | .   | .   | |  .| . ||. |.|.... | .|  |.  .     ....|.   |..|.. .    |.  .  . |  .||      
sDyvnasfvkgnkhrlit.tqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkg..vttfGdvsvvllsvsereGfikr.elevtkgkak

NSIICNVTVISNWKVDTVPLKQ-AIAIKEALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKlAEPCIADIVKSIRSQRPRAVDSFCQY
.  . .     .| ...|. |. | .. . .       .  |.   ..    | ||.| .|..   |  .  .  |  | ..|| .| .||  |    ||
arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakre.kevdifglvkklrqerpylvqtkeqy

CSLYISLLYF
  .|  .| .
kfvyvavlea
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 250-438 1.9e-07 25.3 In-house 69-267 (270) alignment 
Range on Protein: 250-438
Range on HMM: 69-267/270.0
GQAPVTNTEETFWKAVFDKRITHIDLLVG------DETIEFFPKKAEDYTNYGQMWINNRRVEYVNDDVYRF-AIEVVPHGCSNSIIcnVTVISNWKVDT
 ..|. .| . ||. ..... | | .. |      ..   ..|..... ... .. |. . .. .... |..  ...  .| .. ..       .|  ..
amgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlv..HfwyntWpdhg

VPLKQAIAIKeALGLNYFLLKA--PADEH-----AMIVSPRGAGRAGYFLALAVAVNTIDTKLAEPCiADIVKSIRSQRPRAVDSFCQYCSLYISLLYFI
|| ..  ... .  | . | .     .|.      ..    | ||.| ..||  ||......    . . |.. .| .|.  |.   ||  || ... ..
vpreedssls.tdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiavrlLeetkkvdv.laiieelRkdRmalvqhpeqyeflykavveya

KKK
...
err
0041856 (Phosphotyrosine protein) phosphatases II 210-439 5e-07 25.0 In-house 1-175 (182) alignment 
Range on Protein: 210-439
Range on HMM: 1-175/182.0
NPKFNQSEDFPALDSNLvklGKDYVNISLVDVPLGR-NVHLGQAPVTNTEETFWKAVFDKRITHIDLLVgdeTIEFFPkkaedytnygqmwinnrrveyv
| . |  .|..  | ..   . ||.| .|.. .|   . .. |.|  .| . |.. . . .||.|  |        .|                      
nldknrysdilpydhsr...dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...eelywp......................

nDDVYRFAIEVVPHGCSNSIICNvtvisnwkvdTV----------PlkqaiaikealglnyfllkapADEHAMIVSPRGAGRAGYFLALAVAVNTidtkl
 ....|  |... ...    ...          .                                  ..   .    | ||.|.. |. .         
.ellerlgiqylylpwpDhgvpd..........ldelldfieevle.....................eggpvlVHCsaGvgRtgtlvaaylmkkl.....

aEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKV
 .  . ..|| .||.|| .| .  ||  |.  ||.... |.
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_PTPRD_pd Subfamily PTPRD 182-301 8.6e-07 23.0 In-house 308-441 (564) alignment 
Range on Protein: 182-301
Range on HMM: 308-441/564.0
DTAEVKKEYDKLQ-SQKIDVEKD-CKTWKSNPKFNQSEDFPALDSNLVKLG-------KDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRIT
.......|...|. ...|..|.  . | . | | |.  .  ||.|. |.|         ||.| | ..   ... ..  |||..|| | ||. |... ..
emtgleleFqrLatakeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntvedfwrmvweeevk

HIDLLVGDET--IEFFPKKAED--YTNYGQMWIN
 | .| . |    |.. .   |   |.||.. |.
iivmltkleekleeesseyysdleatkyGeitik
0043147 (Phosphotyrosine protein) phosphatases II 231-428 1.5e-06 23.6 In-house 5-154 (172) alignment 
Range on Protein: 231-428
Range on HMM: 5-154/172.0
KDYVNISLVDVPLG-RNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGDetieffpkkaedytnygqmwinnrrveyvnddvyrfaievvPHGCSNSII
 ||.| |..|..   ...  .|.|  || . ||. . .. ||||  | .                                           . ...   
sdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................lydpeller

CNVTVISNWKVDTVPLkQAIAIKEALGLNYFLLKAPADEHAMIVSPRGAGRAGYFLALAVAVntidTKLaepCIADIVKSIRSQRPRAVDSFCQYCSLY
 .....     |  .   .  . |.| . . ||    ..   .    | ||.|.. |.         .|    . ..|. .|..|| || .. ||  ||
lgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml....lgl...sleeavalvrekRpgavqnpsqyrfly
subfamily_PTPN1_pd Subfamily PTPN1 203-310 1.6e-06 22.0 In-house 25-140 (290) alignment 
Range on Protein: 203-310
Range on HMM: 25-140/290.0
DCKTWKSNPKFNQSEDFPALDSNLVKLG---KDYVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLvgDETIEFFPKKAEDYTNYGQ-
     ..| . |.  |    |   .||    .||.| |||... . |.  | | |..|| . ||. |....   . .|  .. .|    |  .|   |. 
reaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml..nkvvekeqikcaqywPqgee

---MWIN--NRRVEYVND
   . ..  . .|.... 
ekellledtklkvklise
subfamily_eak_pd Subfamily eak 231-439 1.7e-06 21.7 In-house 78-309 (332) alignment 
Range on Protein: 231-439
Range on HMM: 78-309/332.0
KDYVNISLVDVP-LGRNVHLGQAPVTNTEETFWKAVFDKRITHIDLLVGD--ETIE----FFPKKAEDYTNYGQMWINnrRVEYVNDDVYRFAIEVVPHG
. |.| ||.. . .||.  |  ..  .    ||. |....   |  |. |  . .|    .||.|. .  ..|.. ..  | |.|. .....   ..  |
lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildve..rkefvkrniletrllelskG

CSNSIICNVTVIsNWKVDTVPLKQ-AIAIKEAL---G-LN----------YFL---LKAPADEHAMIVSPRGAGRAGYFLALAVAVNTIDTKLAE-PCIA
     .   .|   |   |.|  .  .|.....   | |.           .|    ..|     .| | ||. ||| |. . . .. || |  .   . 
nethrvlhykvf.GwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysve

DIVKSIRSQRPRAVDSFCQYCSLYISLLYFIKKKV
|..  ..|.|  .|    |.  .|  .| ..... 
dlilkvkskrihsvlvalqhsfiyeivldyllrrn
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 223-432 1.8e-06 21.3 In-house 56-273 (515) alignment 
Range on Protein: 223-432
Range on HMM: 56-273/515.0
DSNLVKL-------GKDYVNISLVDVPLG-RNVHLGQAPVTNTEETFWKAVFDKRITHIDLLV----GDET--IEFFPKKAEDYTNYGQMWINNRRVEYV
||. |||        .||.| | .      .     |.|   . . ||. |.....| | ..     ||     ...|.|  |  ..|.. ..   .|  
dsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleac

NDDVYRfAIEVVPHGCsNSIICNvTVISNWKVDTVPLKqaiaikeALGLNYFLLKAPAD----EHAMIVS-PRGAGRAGYFLALAVAVNTIDTKLAePCI
 . . |  ..|.        .       .|    || .       .  |  .. .  ||    .|..|.    |.||.| ....   |  . |  .   .
tggikr.kltvlkgdd.srtvtq.fhfteWPdkGvpkh.......tssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrm.vdv

ADIVKSIRSQRPRAVDSFCQYCSLYISLL
 ..|. || .||  |    ||  .|  .|
fnfvtnirqkrpylvqtqeqyafiygavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 249-432 3.8e-06 21.2 In-house 55-237 (239) alignment 
Range on Protein: 249-432
Range on HMM: 55-237/239.0
LGQAPVTNTEETFWKAVFDKRITHIDLLVGdeTIEFFPKKAEDYT-----NYGQMWINNRRVEYVNDDVYRFAIeVVPHGCSNSIICNVTVISNWKVDTV
  |  |. .   ||. ....|   | .| |   || . ||. .|      .| .. .  |. | . | . |  . .   | ..        .. |    |
atqgcveissgdfwrmmwqerrcvivmltg..lieghkkkchqywpdstskycnlrvtlrktevfadyiirtfv.msqvgqteeryvyqyhftvwpdkgv

PlKQAIAIkeaLGLNYFLLK--APADEHAMIVSPRGAGRAGYFLALAVAVNTIdTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISLL
| . | |.   |||   . |   |     .|    | ||.| || .   .     |     | . ||.|| .||. |..  ||  .....|
p.qyatav...lglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 249-431 4.2e-06 21.1 In-house 56-237 (239) alignment 
Range on Protein: 249-431
Range on HMM: 56-237/239.0
LGQAPVTNTEETFWKAVFDKRITHIDLLVGdeTIEFFPKKAEDYT-----NYGQMWINNRRVEYVNDDVYRFAIeVVPHGCSNSIICNVTVISNWKVDTV
  |  |. .   ||. ....|   | .| |   || . ||. .|      .| .. .  |. | . | . |  . .   | ..        .. |    |
atqgcveissgdfwrmmwqerrcvivmltg..lieghkkkchqywpdstskycnlrvtlrktevfadyiirtfv.msqvgqteeryvyqyhftvwpdkgv

PlKQAIAIkeaLGLNYFLLK--APADEHAMIVSPRGAGRAGYFLALAVAVNTIdTKLAEPCIADIVKSIRSQRPRAVDSFCQYCSLYISL
| . | |.   |||   . |   |     .|    | ||.| || .   .     |     | . ||.|| .||. |..  ||  .....
p.qyatav...lglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa.kkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 183-432 5.3e-06 20.1 In-house 19-233 (392) alignment 
Range on Protein: 183-432
Range on HMM: 19-233/392.0
TAEVKKEYDKLQSQKIDVEKDCKTwKSNPKFNQSEDFPALDSNLVKL-------GKDYVNISLV-DVPLGRNVHLGQAPVTNTEETFWKAVFDKRITHID
.| . .|.  | . .|  .. ... . | | |. ..   .||. |||        .||.| | .  .   .     |.| . . . ||. ||....| | 
salffeefhdlpgpdiypqtvaqk.einlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttia

LLVG----DetieffpkkaedytnygqmwinnrrveyvnddvyrfaievvpHGCSNSIiCNVTVISNWKVDTVPLKQAIAIKEALGlnyflLKAPADEHA
..      |                                          .| ..   .    ...|  . || . .  .|         .||   ...
mvtklkegd..........................................kgddart.vaqfhftewPdkdvpkhtssllkfike.....vkadfGqyt

---MIVSPRGAGRAGYFLALAVAVNTI-DTKLAEpcIADIVKSIRSQRPRAVDSFCQYCSLYISLL
   .|    | ||.|  ...   |     |.. .  . ..|  || .||  |..  ||. .| ..|
hpliihcsagvgrtgvvisidsvvahakktrmvd..vfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 225-435 6.4e-06 20.2 In-house 59-277 (287) alignment 
Range on Protein: 225-435
Range on HMM: 59-277/287.0
NLVKLGKDYVNISLVDVPLGRNVHL-GQAPVTNTEETFWKAVFDKRITHIDLL---VGDETIE---FFPKKaEDYTNYGQMWINNRRVEYVNDDVYRFAI
.  .|| ||.|   |      . ..  |.|.. |   ||.||...| . . ..   | .   .   ..|.. |     |   .     .  . .    |.
aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvral

EVVPHGCSN-SIICNVTVIsNWKVDTVPLKQAIAIKEALGL-NYFLLKAPADEHA--MIVSPRGAGRAGYFLALAVAVNTIdTKLAEPCIADIVKSIRSQ
 ..     .  .. .. .. .|  ....      |. .|   ..  |.  |.|    ..    |.||.| .||. | |.    .| .  .| .|  .| .
rlidletrearvvkqldll.swPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrl.edlGrvdvaavvirlrey

RPRAVDSFCQYCSLYISLLYFI
|   | .  |.  || .|  . 
raalvqavvqlrllyealvtyy
0049772 (Phosphotyrosine protein) phosphatases II 209-438 8.3e-06 21.2 In-house 45-283 (314) alignment 
Range on Protein: 209-438
Range on HMM: 45-283/314.0
SNPKFNQSEDFPALDsNLVKLG------KDYVNISLVDVPlgRNVHLGQAPVTNTEETF----------WKAVFDKRITHIDLLV---------------
 |.. | . |..  | |.|.|.       || |.| || .  ..    |.|  .| . |          |. |..  .  .|.                 
lnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf..lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLda

------GDETIEFFpkkAEDYTNYGQMWInnrrveyvnddvyrfaiEVV--PHGCSNSIICNVTVisNWKVDTVPLKQAiaikeALGLNYFLLKAPADEH
        .  ...   .|    . ...                  |..  |. ... .|  . .  ..  ...|| .       . .  |...|.... 
AlgKtpllildgng...neptaadlellk.................eelydpelferlgikylri..pvpDgsaplled.....fdeflefieeadkggp

AMIVSPRGAGRAGYFLALAVAVNTIDtklaePCIADIVKSIRSQRP-----RAVDSFCQYCSLYISLLYFIKKK
  .    | ||.| |...|  .   .      ....... .|..||     ... ...||.  .  ||...|..
vlvHCkaGkgRtgtfvvaaylmkllg.....vsleealedvrlkRpinpnpgfieqleqyefilealleylkfl