Gene Y22D7AR.12 in Caenorhabditis elegans

Synonym: CELE_Y22D7AR.12, Y22D7AR.12

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP210_AA protein Get Run
CeleP210_AA_776-1056 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 778-1074 1.1e-126 416.8 In-house 1-289 (290) alignment 
Range on Protein: 778-1074
Range on HMM: 1-289/290.0
LISIKLEALTFNTRWVESHAMDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFPSNLCMILTQAPQAKNlgdpyavirISKRNSTIEKFLWMAMQEG
|.|....|....|..|..|.||.|....|.  .||.|||||||..|.||||..|..|..|..||||.||.|.         ..|||||||||.|||.|| 
lrskestavllktdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqeki.........tekrnStiekfwwmakqEk

VKHVVQLCERTLPRSNTSDdEydACSVYVPDNVGEELKFEGVTMKCtdCKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDM
||.||.|||.. ...|||. .  ||. |||..|||||||.|.|.||  ..||..|.||.| .|||||| .|||..|....|| |....|..||.|.|...
vkqvVmlcefeeksantsl.f..aCakYvpesvgeelkfkgltvkC..kskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqk

VNASKTPVIVHCYDGRSRSACFAYMELACQMVA-KNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGAMMRLMEVGKATCRNEFE-----EYQQWYNEW
|.||||||||||.||.||||..|...|..|..| ...||.....||||.|.||.......|.||...|......||.......|.|     |....|...
vkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeeketykki

YQT
.|.
kql
0040438 (Phosphotyrosine protein) phosphatases II 777-1062 2e-50 167.2 In-house 26-289 (317) alignment 
Range on Protein: 777-1062
Range on HMM: 26-289/317.0
ELISIKLEaLTFNTRWVESHAMDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFPS-NLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQ
.|.|.||.  .  ....|.. ...     . . .|| |. .|..|...||.||.|..|. .  .|.||.|.                ..|.|.|..| ..
dllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl................pntvedFwrmvwe

EGVKHVVQLCErtlprsnTSDDEYDACSVYVPDnvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLAL
.||...| |.|       . ...   |  | |.  ||.|.....|........  ......|.. |.  .| ...| .|..| ||   ..|.||...|..
qgvtvivmLte.......leelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldf

LDMVNAS----KTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGAMMRLMEVGKATCRNEFE
|..|...    ..||.||| .| .|...|. ..|..... |.  |.   |.| | ..|.. .   | | | .. ... |. ... .. .|. 
leavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselk
0036941 (Phosphotyrosine protein) phosphatases II 792-1047 8.3e-45 148.7 In-house 36-275 (297) alignment 
Range on Protein: 792-1047
Range on HMM: 36-275/297.0
WVESHAMDHRAQNALAPGNRVALkgygKRLSDGYIHASFVSFPS-NLCMILTQAPQAknlgdpyaviriskrnSTIEKFLWMAMQEGVKHVVQLCERTLp
..|   ...       . .|| |    .  ...||.||.|.... .  .|.||.|.                 .|.|.| .| ....|...| |.| .  
lpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlp................ntvedFWrmvweqnvtvIvmltelve.

rsntsdDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA------SKT
      ..   |  | |...||.|.....|........ ..|.. .|.. |.. .. ...| .|..| ||   ..||||...|.....|.       |..
......lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsgg

PVIVHCYDGRSRSACFAYMELACQMVA---KNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGAMM
||.||| .| .||..|. ..|..|..    |.  |.   |.| |...|.. .   | | | ..  ..
pvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0050432 (Phosphotyrosine protein) phosphatases II 779-1044 6e-42 139.4 In-house 52-294 (308) alignment 
Range on Protein: 779-1044
Range on HMM: 52-294/308.0
ISIKLEALTFNTRWVESHAMDHRAQNALAPGNRVALkgygkRLSDGYIHASFVSFP---SNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQ
 |.|    .. ....| . .           .|| |       ...||.||.|...   ..  .|.||.|                 ..|.|.| .| ..
lsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPl................pntvedFwrmvwe

EGVKHVVQLCERTLprsntsdDEYDACSVYVPDNVG-EELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLA
..|...| |.. .        ..   |  | |...| . |.....| .......  .|.. .|.. ... .| ...| .|..| .|   ..|.||. .|.
qnvrvIvmLtklve.......ngrekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilld

LLDMVNAS--KTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYG
.|..|. |  . |..||| .| .|...|. ..|..... |.  |.   |.| | ..|.. .   | | | .. 
flelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyra
Y_phosphatase Protein-tyrosine phosphatase 807-1042 8.1e-42 138.6 Pfam-A 13-230 (235) alignment 
Range on Protein: 807-1042
Range on HMM: 13-230/235.0
APGNRVALKGYGKRLSdgYIHASFV-SFPSNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCERTLPrsntsDDeyDACSVY
.  .|| |||....    ||.|..| .....  .|.||.|                 .||||.| .| .|| || .|.|.. .       ..   .|. |
ydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPl................kstiedFWrmvwqekvkvivmltsleek.....gr..ekcaqY

VPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKFDDLKE--FTFNHYWYRGWGKSSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACF
.|.. .|.|... ......  .|| ..|. .|.. .| .. ..  .......| .| ....||||| .| |...|. ||    .||.||| .| .|...|
wpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtf

AYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAI
. ........ ....|    ..| | | |.... . |.|.| .
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly
Y_phosphatase Protein-tyrosine phosphatase 807-1042 8.1e-42 138.6 In-house 13-230 (235) alignment 
Range on Protein: 807-1042
Range on HMM: 13-230/235.0
APGNRVALKGYGKRLSdgYIHASFV-SFPSNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCERTLPrsntsDDeyDACSVY
.  .|| |||....    ||.|..| .....  .|.||.|                 .||||.| .| .|| || .|.|.. .       ..   .|. |
ydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPl................kstiedFWrmvwqekvkvivmltsleek.....gr..ekcaqY

VPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKFDDLKE--FTFNHYWYRGWGKSSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACF
.|.. .|.|... ......  .|| ..|. .|.. .| .. ..  .......| .| ....||||| .| |...|. ||    .||.||| .| .|...|
wpeeeeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtf

AYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAI
. ........ ....|    ..| | | |.... . |.|.| .
valdilleqleaeeevdvlqivkelRkqRpgmvqsleqYifly
0039614 (Phosphotyrosine protein) phosphatases II 784-1047 2.6e-41 137.4 In-house 47-287 (297) alignment 
Range on Protein: 784-1047
Range on HMM: 47-287/297.0
EalTFNTRWVESHAMDHRAQNALAPGNRVALKGYGKR-LSDGYIHASFVSFPS--NLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKH
.  .  ....|.  .         . .|| ||..... |.. ||.||.|....  .  .|.||.|. .                |.|.|..|  ..||..
d..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe................tvedFwrmvweqgvtv

VVQLCErtlprsnTSDDEYdACSVYVPDNVGeelKFEGVTMKCTDCKKefNDEVEIRVVVVKFDDLKeFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA
.| |..       . ...   |  | |...|   .....| .......  .| . .|.  |. ..   .| .|..| ||   ..|.|....| .|..|. 
ivmLtk.......lvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtnnges.rtvthfqytgwpdhgvppslellleflelvre

------SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGAMM
      ...||.||| .| .|...|. . |..... |.  |.   |.| | ..| . .  .. | | .. ...
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0045450 (Phosphotyrosine protein) phosphatases II 788-1047 3.2e-41 137.4 In-house 48-302 (307) alignment 
Range on Protein: 788-1047
Range on HMM: 48-302/307.0
FNTRWVESHAMDHRAQNALAPGNRVALKGYGKR-LSDGYIHASFVSFP---------SNLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEG
  ....|.. .       . . .|| |. ....  ...||.||.| .|         ... .|.||.|. .                |.|.|..|  ..|
siallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe................tvedFwrmlweqg

VKHVVQLCERTlprsntsDDEYDACSVYVPDNvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKF--DDLKEFTFNHYWYRGWGKSSIPESPKTMLALL
|...| |.| .       ...   |  | ||. |||| .. .|..... ..   |.. .|.. |.    . ...| .|..| ||   ..|.|....|...
vtvivmltelv.......elgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfi

DMVNA------SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDS---VTSRVALKALMKMRANLFVKDEEYAFAIYGAMM
..|..      ...||.||| .| .|...|. . |..... |.     |. . |.| | ..| . .   | | | .. ...
eevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 790-1044 5.5e-41 136.2 In-house 6-241 (249) alignment 
Range on Protein: 790-1044
Range on HMM: 6-241/249.0
TRWVESHAMDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFP-SNLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCERT
....|.. ..        . .|| |. ....  ..||.||..... ..  .|.||.|  .                |.|.|..|  ..|....| |.. .
allpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe................tvedfwrmlwelgitvivmLtslv

LPrsntsddEYDACSVYVPDnvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA------S
 .       ..  |  | |.  |..|.....| .......  .|.. .|.. ...  | ...| .|..| .|   ..|.|....|.....|.       .
el.......grekcaqywpl..ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpk

KTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYG
..||.||| .| .|...|. . |..... |.  |.   |.| | ..| . .  .| | | .. 
ggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 791-1043 3.7e-40 133.3 In-house 5-237 (245) alignment 
Range on Protein: 791-1043
Range on HMM: 5-237/245.0
RWVESHAMDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFPS-NLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCERTL
...|.. .    .  . . .|| |. .| .| ..||.||.|...  .  .|.||.|...                |.|.|..|  ..|....| |.| . 
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe................tvedfwrmlwelgittivmLteeee

prsntsdDEYDACSVYVPDnvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA-----SKT
       ..   |  | |.  ||.|.....|........  .|.. .|.. |.   | .... .||.| .|   ..|......| .|..|.      |..
.......lgrvkcaqywpl..gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsng

PVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIY
||.||| .|..|...|. . |..... |.  |.   |.| | ..| . .  .. | | ..
pvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflye
0043336 (Phosphotyrosine protein) phosphatases II 783-1043 6.4e-40 132.8 In-house 34-271 (278) alignment 
Range on Protein: 783-1043
Range on HMM: 34-271/278.0
LeALTFNTRWVESHAMDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFPS-NLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHV
|   .  ....|.. .       . . .|| |. .|..|...||.||.|.... .  .|.||.|. .                |.|.| .|  ..||...
l.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe................tvedFwrmvwelgvtti

VQLCERTLprsntsdDEYDACSVYVPdnvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA
| |.| .        ..   |  | |   |. |.....| .......  .| . .|.  |.   | ...| .||.| ||   ..|||....| .| .|. 
vmLtelve.......lgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

----SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIY
    |..||.||| .| .|...|. ..|..... |.  |.   |.| | ..|.. .  .. | | ..
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflye
0047943 (Phosphotyrosine protein) phosphatases II 787-1043 6.8e-40 132.6 In-house 30-266 (273) alignment 
Range on Protein: 787-1043
Range on HMM: 30-266/273.0
TFNTRWVESHAMDHRAQNALAPGNRVALkgygKRLSDGYIHASFVSF-PSNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLC
.  ....| . ..          .|| |    .  ...||.||.|.. ...  .|.||.|                 ..|.|.|..| ....|...| |.
ysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPl................pntvedfwrmvweqnvrviVmLt

ERTLprsntsdDEYDACSVYVPDNVGE-ELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA---
| .        ..   |  | |...|| .|... .| .......  .| . .|.. ... .. ...| .|..| ||   ..|.|.. .| ....|.    
elve.......lgrekcaqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

---SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIY
   |..||.||| .| .|...|. ..|..... |.  |.   |.| | ..| . .   | | | ..
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
DSPc_SM00195 798-1047 1.1e-39 131.8 In-house 29-259 (263) alignment 
Range on Protein: 798-1047
Range on HMM: 29-259/263.0
MDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFP-SNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCERTLPrsntsd
..   .  .   .|| ||   |. .. ||.|...... ..  .|.||.|.                .||.|.| .| ..|.|| .| |.|          
knRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl................pstvedFWrmvweekvkiivmlteeeen......

dEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFnDEVEIRVVVVKFDD-LKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASKT----PVIVHCYD
 .   |. |.|.. |.. .|. .. |.....|.  ||...|.. .....  .......|.|..| ....|.|.| .|.|| .|. ||     |..||| .
.gkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAiYGAMM
| .|...|. ...... ..... |     .|.| | |.... ..|.|.|. | |..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi.yeail
PTPc_SM00194 798-1047 1.1e-39 131.8 In-house 29-259 (263) alignment 
Range on Protein: 798-1047
Range on HMM: 29-259/263.0
MDHRAQNALAPGNRVALKGYGKRLSDGYIHASFVSFP-SNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCERTLPrsntsd
..   .  .   .|| ||   |. .. ||.|...... ..  .|.||.|.                .||.|.| .| ..|.|| .| |.|          
knRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl................pstvedFWrmvweekvkiivmlteeeen......

dEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFnDEVEIRVVVVKFDD-LKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASKT----PVIVHCYD
 .   |. |.|.. |.. .|. .. |.....|.  ||...|.. .....  .......|.|..| ....|.|.| .|.|| .|. ||     |..||| .
.gkekcdrywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsa

GRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAiYGAMM
| .|...|. ...... ..... |     .|.| | |.... ..|.|.|. | |..
GvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi.yeail
0046845 (Phosphotyrosine protein) phosphatases II 805-1047 1.4e-39 131.6 In-house 38-272 (284) alignment 
Range on Protein: 805-1047
Range on HMM: 38-272/284.0
ALAPGNRVALKGYGKR-LSDGYIHASFVSFP------SNLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCERTLprsntsdD
     .|| || ....  ...||.||.|...      ..  .|.||.|                 ..|.|.| .| ....|...| |.| .        .
lpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPl................pntvedFwrmvweqnvrvIVmltelve.......n

EYDACSVYVPDNvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKFD--DLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNAS------KTPVIVHC
..  |. | |.. || |.....| .......  .| . .|.. ...   . ...| .|..| .|   ..|.||. .|..|..|. .      . |..|||
grekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHC

YDGRSRSACFAYMELACQMVAKND---SVTSRVALKALMKMRANLFVKDEEYAFAIYGAMM
 .| .|...|. ..|..... |..    |.   |.| | ..| . .   | | | .. ...
saGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealle
0051299 (Phosphotyrosine protein) phosphatases II 806-1045 2.8e-39 130.7 In-house 60-282 (288) alignment 
Range on Protein: 806-1045
Range on HMM: 60-282/288.0
LAPGNRVALKGYGKRLSDGYIHASFVSF-PSNLCMILTQAPQAknlgdpyaviriskrnSTIEKFLWMAMQEGVKHVVQLCERTLprsntsdDEYDACSV
    .|| |. ...  ...||.||.... ...  .|.||.|                  .|.|.| .| ....|...| |.. .        ...  |  
pydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp................ntvedFWrmvweqnvrvIvmltklve.......lgrekcaq

YVPDnvGEELKFEGVTMKCTDCKKefNDEVEIRVVVVKF-----DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNAS----KTPVIVHCYDGRSR
| |.  |. |... .| .......  .|.. .|.. |.       | ...| .|..| .|   ..|.||. .|..| .|. .    . ||.||| .| .|
Ywpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgR

SACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGA
...|. ..|..... |.  |.   |.| | ..| ...   | | | .. .
tgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyeal
0045098 (Phosphotyrosine protein) phosphatases II 795-1043 1.4e-33 111.9 In-house 33-266 (278) alignment 
Range on Protein: 795-1043
Range on HMM: 33-266/278.0
SHAMDHRAQNALAPGNRVAlkgygkrlsdGYIHASFVSFPsNLCMILTQAPQAknlgdpyaviriskrnSTIEKFLWMAMQEGVKHVVQLCErtlprsnT
. ...   .    . .||           .||.||..... .  .|.||.|                  ||...|. |  ..|....| |.|        
nldknRykdilpydhsrVk..........dYINAsyidgy.pkkfIatqgPlp................stvadfwrmlwelgitvivmlte.......l

SDDEYDACSVYVPDnvGEELKFEGVTMKCTDCKKEfnDEVEIRVVVVKF-----DDLKEFTFNHYWYRGWGKSSIPESP--KTMLALLDMVNA-------
 ...   |  | |.  |. | ....| ......    |.. .|.  |        ||......|..| .|   ..|..|  | .| ||.....       
velgrekcaqywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

----------SKTPVIVHCYDGRSRSACFAYMELACQMVakNDSVTSRVALKALMKMRAN-LFVKDEEYAFAIY
          |..||.|||. | .|..... . | ....  .. |.   |.| | ..| .  .   | | | ..
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflye
0037934 (Phosphotyrosine protein) phosphatases II 808-1042 3e-27 91.2 In-house 23-235 (243) alignment 
Range on Protein: 808-1042
Range on HMM: 23-235/243.0
PGNRVALKGygkrlsDGYIHASFVSFPSNlcMILTQAPQAKNLGDpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCERT-LPRSntsddeydACSVYV
. .|| |.|      ..||.|...  . .  .|.||.|  ... |            . ..|. |  ..|....| |.| . | |          |  | 
dhsrvkleg......sdyinanliyvtpr..liatqgPlpetved............dlasfwrmlwelgitvivmltelvElgre........kcaqyw

PdnvGEElKFEGVTMKCTDCKKefNDEVEIRVVVVKF--DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVN------------ASKTPVIVHCYDG
|   ||.  ....| ......    |.. .|.....    |  ...  ||.| .|   ..|.||. .|..||.|.             |. ||.|||. |
p...gev.tygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

RSRSACFAYMELACQMVakndSVTSRVALKALMKMRAN-LFVKDEEYAFAI
..|..... . | ....    .|.   |.| | ..| .  .   . | | .
vgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrfly
WSN Domain of unknown function 1-59 2.7e-24 74.9 Pfam-A 10-68 (69) alignment 
Range on Protein: 1-59
Range on HMM: 10-68/69.0
MQMITRIINGIYLQQGLSTKSIPSEELVSELLNLGSVTTSQIAAIDTAKLKTVVDKINE
...| |..||||||.||...|||......||||.||...||. .||..|||. ..|..|
lsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 862-1051 2.8e-23 77.1 In-house 99-283 (301) alignment 
Range on Protein: 862-1051
Range on HMM: 99-283/301.0
RNSTIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVK--FDDLKEFTFNHYWYRGW
 ..| | |  | .|  |...| |...        ... . |. |.| ...|.|. .  ..| .. .. .|...  | . |.   ....  |  || |  |
lkntsedfwamlvqydvekivmlgqkv.......ekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysew

GKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGAMMRLME
 .  .|.|   .  |...|  |. |..||| .|  || .|   |   . |  .  .    ||| | . | |   . .   .   |.. ||. 
tdrgvPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlik
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 863-1066 3.2e-23 77.1 In-house 38-236 (255) alignment 
Range on Protein: 863-1066
Range on HMM: 38-236/255.0
NSTIEKFLWMAMQEGVKHVVQLCERTLprsntsdDEYDACSVYVPDNVGEELKFEGVTMKCTDckkEFNDEV-EIRVVVVKFDDL-KEFTFNHYWYRGWG
  |..||. . .| . . || ||. .        .. . || | | .  | ||.. |.. .|.     .| |   .... .. .  |  | .|| |.|| 
sltvdkfyqtivqtktevvvmlcdfae.......egvekcssyfplekdeklkladvnvtttk...ssadvvlrtleitstlgekkkthtvkhysykGWi

KSSIPESPKTMLALLDMVNASkTPVIVHCYDGRSRSACFAYMELACQ--MVAKNDSVTSRVALKAL----MKMRANLFVKDEEYAFAIYGAMmRLMeVGK
.   || .. .| .| .|  |  .|.|||  |  ||| |. .||. |  . . . . |  .  . |     ..|.    .  . ||.|.  .  |.   |
eknaPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl.dlv.fpk

ATCRNEFEEYQQ
.   ....| ..
geleakyqeirk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 862-1040 4.9e-21 69.6 In-house 103-274 (290) alignment 
Range on Protein: 862-1040
Range on HMM: 103-274/290.0
RNSTIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGK
 ..|.  .  | .||.|  .| |||         .|    |. | |.. || | |  .|. |.  ... .. .   . | . |. ||  ..|.  . |  
lkdtvidiwrmvlqekvaaivmlceli.......edGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpd

SSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAF
 |.. |  ..| .| ..     ||.|||  |  |.  |. .| . |.. .  ..      .|| . |.|    | .|  
ksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqyla
subfamily_hpo-7_pd Subfamily hpo-7 864-1066 5.1e-21 69.7 In-house 45-242 (263) alignment 
Range on Protein: 864-1066
Range on HMM: 45-242/263.0
STIEKFLWMAMQEGVKHVVQLCERTLprsntsdDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKefnDE-VEIRVVVVKFD-DLKEFTFNHYWYRGWGK
 ||.||. .  | . . || ||. .        .. . || | | .  | .|.. |.. .|. ..   |  .  ....  ..   |  |..|| |.|| .
qtidkfyqtivqtktevvvmLcDfne.......egvekcssyfPlekdekqklanvnvcttkvqs...dvllktlellstlgeKkkthtvkhysykgWie

SSIPESPKTMLALLDMVNASkTPVIVHCYDGRSRSACFAYMELACQ--MVAKNDSVTSRVALKAL----MKMRANLFVKDEEYAFAIYgamMRLMEVGKA
   || .. .| .|...  |  ...|||  |  ||| |. .||. |  . . . . |  .    |     ..|.    .    ||.|.   | |  | ..
kndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil...mvLdfvlnn

TCRNEFE-EYQQ
  ..| | .||.
fakgeleakyqe
0051429 (Phosphotyrosine protein) phosphatases II 863-1061 5.5e-19 64.3 In-house 32-240 (272) alignment 
Range on Protein: 863-1061
Range on HMM: 32-240/272.0
NSTIEKFLWMaMQEGVKHVVQLCERTLPRSNTSDD---EYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGW
. |.. | ..  ..|.|..| |.. .   ..  |      . . . ..|.. ..  .  ...... ..   .  .   ... ...  . ... |..|..|
pltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdw

GKSSIPESPktMLALLDMVNAsKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVT--------SRVALKALMKMRANLFVKDEEYAFA---IYGAMMR
   ..|...  .|.||..... . ||.|||. |..|..... . |  . | ... |          . |.. |...|.. .  .| |.|    .  ....
pdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrs

LMEVGKATCRNEF
|..|  .. .  .
llsvraeyllaal
0041856 (Phosphotyrosine protein) phosphatases II 822-1043 5.8e-19 63.8 In-house 18-165 (182) alignment 
Range on Protein: 822-1043
Range on HMM: 18-165/182.0
SDGYIHASFVSFPSNL-CMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCertlprsntsddeydaCSVYVPdnvgeelkfegvt
   ||.|... ..     .|.||.|  .                |...|| |  ..|....| |.                .  | |             
dldyInanlylgslpatrfiatqgplls................tvadflrmlkelgittivnlt................eelywp.............

mkctdckkE-FndeveirvvvvkfddlkEFTFNHYWYRGWGKSSIPEsPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMvakndSVTSRV
        | .                 | .  .|.| .|   ..|. . ..|.....|.... ||.|||  |..|..... . | ...     .|. . 
........ell.................erlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

ALKALMKMRANLFVKDEEYAFAIY
|.| . ..| . ..  . | |  .
avklvrsrRpgmvitpnqyfflql
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 794-1055 3e-18 61.0 In-house 45-288 (305) alignment 
Range on Protein: 794-1055
Range on HMM: 45-288/305.0
ESHAMDHRAQNALAPGNRVALKGYGKRLSDGYIHASFV-SFPSNLCMILTQAPqaknlgdpYaviriskrNSTIEKFLWMAMQEGVKHVVQLCertlprs
...| .. ... | . .|. |.   .     || ||.| .. .. . |..|.|                 ..|.. |  . ..| |...|.|.       
ankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgP........l........kntvadfWrliveekvstivmlt.......

NTSDDEYDACSVYVPDNVGEELKFEGVTMKCTDcKKEFNDEVEIRVVVVK-FDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVN----ASKT-PVI
.. ... | |  | |....|. .|. .... .. .|...| .| .. . .  .| .. |  .|    |    .|... ..| |.. |.     .|  |..
klveggkdkCrqYWpesktekkefgefsvelks.ektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpll

VHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKA
||| .| .|.  |  ...| . . | ..|     ||.| . | ..  . ..| | .. |.  |.. |..
VhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvf.lhdaldelitcgdt
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 864-1051 1.1e-17 59.1 In-house 101-280 (288) alignment 
Range on Protein: 864-1051
Range on HMM: 101-280/288.0
STIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPDNvGEELKFEGVTMKCTDCKkEFNDEVEIRVVVVkfDDLKEFTFNHYWYRGWGKSS
.|...|  .  .. .. .| | |         ...   |  | ||. ... ..  ||.. .. | | .| |. .. ..   . .|.. ..| | .|   .
dtvndfWelvyenktstivmltelv.......eggktkCeeYWPda.dkpknyGsvtvtlvesk.eledfvlrkllle..kkkteleitqyqylaWpdhg

IPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLME
.||| . .|.||..|. ..     |.|||| .|  |.  |  .. . ..| ..| .    ... | | ||.|  . . | | || ... |.|
vPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYef.iyevllslie
0051082 (Phosphotyrosine protein) phosphatases II 824-1041 1.5e-17 59.1 In-house 4-145 (151) alignment 
Range on Protein: 824-1041
Range on HMM: 4-145/151.0
GYIHASFVSfPSnlcMILTQAPQAknlgdpyaviriskrnstieKFLWMAMQEGVKHVVQLCERTLPRsntsddeydACSVYVPDNVgeelkfegvtmkc
.||..|.|  .    ......| |                     || .  ..|.|..| |.. . .           |  |.|..              
dyinfsyvt.gg...lyrsggpla....................dflellkelgiktivnlrseeerg.........ycpeylpelg.............

tdckkefndeveirvvvvkfddlkeFTFNHYWYRGWGKSSIPESPKTMLALLDMVNAS-KTPVIVHCYDGRSRSACFAYMELACQMvakndsVTSRVALK
                         ... |... .|   ..|.|....|..|.....  . ||.|||  |..|....... | ...      |.   ||.
.........................ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleeale

ALMKMRANLFVKDEEYAFA
 ....| ...   ... | 
eyrlkrpgvvqpnqqflfq
subfamily_Ptp69D_pd Subfamily Ptp69D 809-1063 4.1e-17 57.3 In-house 62-300 (307) alignment 
Range on Protein: 809-1063
Range on HMM: 62-300/307.0
GNRVALKGYGKRLSDGYIHASFV-SFPSNLCMILTQAPqaknlgdpyavirIskrNSTIEKFLWMAMQEGVKHVVQLcertlprSNTSDDEYDACSVYVP
 .|| ||    . .  || |||. ..  .   |  |.|             .   ..||. |  | ..  |. .| |       || .. . . |. | |
ktRvkLkkingkedsdYinasfikgykekkkfiaaqdP.............v...eatigDfWRmiaeqevtlivml.......snlteknrkkcakYWp

DNvgEELKFEGVTMKCTDC----------------KKEFNDEveirvvvvkfDDLKEftFNHYWYRGWGKSSIPESPKTMLALLDMV----NASKTPVIV
..  .| ... . .|. .                 |.| ...          .| ..     | | ||  | .||.....| |...|    . ...|..|
ie..devqygdilvklvseekhsdyiiReldvskkkeesgev..........edsrk..vvqyhytgWkDskvPevargllklieqvrelyklnrsPivv

HCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVG-KATCRNEFEE
||  | .||. |  ...  | . ..|.|      | | . |  |. . | | | .| |..  .. |    . ...|.
hCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvf.lyralldyssygdtdedvddled
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 807-1047 8e-17 56.1 In-house 32-261 (270) alignment 
Range on Protein: 807-1047
Range on HMM: 32-261/270.0
APGNRVALKGYGKRLSDGYIHASFVSfpsnlcmiltqapQAKNLGDPYaVIRISKRNSTIEKFLWMAMQEGVKHVvqlcertLPRSNTSDDEYDACSVYV
 |  || |.   .     || | .|               ...    | .   .  ..|...|. | ..| |. .       .  ..  ..  . |..| 
sPatRvrleeleedsataYinAnyvr.............GfdgekkkY.iaamgPlpttlksfwrmiweekvtai.......vmttgleEkgrkkCerYW

PDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKfDDLKEFTFNHYWYRGWGKSSIPESPK------TMLALLDMV-----NAS-KTPVIVHCYDGRS
| ...|..|.|  ..| . ...| ..   .. . .. .. .|    |.||  |   ..|...        .|..|  |     . . ..|..||| .|  
paepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvg

RSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAiYGAMM
|. ..  .. |.... .. .|     ...| | | .|  . |.|.|. | |..
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl.ykavv
0043147 (Phosphotyrosine protein) phosphatases II 824-1043 8.2e-17 56.9 In-house 6-155 (172) alignment 
Range on Protein: 824-1043
Range on HMM: 6-155/172.0
GYIHASFVSFPSNL-CMILTQAPqaknlgdpyaviriskRNSTIEKFLWMAMQEGVKHVVQLCERtlprsntsddeydacsvyvpdnvgeelkfegvtmk
 ||.||.....      | ||.|                 ..|...|. |  ..|..|.| |.|.                                   
dyinasyldlyyipdrfiatqgp................lrntladfwrmlkelgithivnltel...................................

ctdckkefndeveirvvvVKFDDLKEFTFNHYWYRGWGKSSIPeSPKTMLALLDMVNA-----SKTPVIVHCYDGRSRSACFAYMELACqmvaknDSVTS
                  ..  .| | .  .|.| .|   . | ... .| .|. ..      .. ||.|||. | .|..... . | .       ... 
..................lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsl

RVALKALMKMRANLFVKDEEYAFAIY
  |.. . ..| . .  .. | |  |
eeavalvrekRpgavqnpsqyrflyy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 862-1044 1.1e-16 55.4 In-house 105-283 (305) alignment 
Range on Protein: 862-1044
Range on HMM: 105-283/305.0
RNSTIEKFLWMAMQEGVKHVVQLCErTLprsntsDDEYDACSVYVPDNVGEELKFE-GVTMKCTDCKKEFNDEVEIR--VVVVKFDDLKEFTFNHYWYRG
 . ||..| || .|. |...| ||  |.      .     |. | |   || |..  |. ..     | .. . ||.  .. . .   ....  |  .  
ldqtidefwwmviqnkveqivmlck.tv......elgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwte

WGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVA-LKALMKMRANLFVKDEEYAFaIYG
|    .|    | | ||  .  || |..|||  |  |.     .|   . .|.| ..      .|||   ||    .| .| | |. 
wpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylf.ihr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 860-1029 1.3e-16 55.5 In-house 89-251 (288) alignment 
Range on Protein: 860-1029
Range on HMM: 89-251/288.0
SKRNSTIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPDNVGEELKFEGVtmkCTDCKKEFND-EVEIRVVVVKFDDLKEFT--FNHYWY
.  |.|||..  | ....|...| |||         .   ..  .| | ..||. ..  .   ||. ||. .| .  ..| ...     | .    .  .
aPlngtieelWkmllesdveyivmlcell.......ekGkeksaeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhl

RGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRA
. | . ..||. .. | ||..... . |..||.  |  |.. .. . .| ...  .| .. |  |. | . | 
leWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsllaklreerf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 789-1043 3e-16 54.3 In-house 21-261 (274) alignment 
Range on Protein: 789-1043
Range on HMM: 21-261/274.0
NTRWVESHAMDHRAQNALA-PGNRVALKGYGKR-LSDGYIHASFVSFPS--NLCMILTQAPQAKNLGDPYAVIRiskrnstiekflwmamqegvkhvVQL
.   |  ..   | .. |  .  || |.    .     || | ..  ..  . . . || | .. . | . .|                         . 
eeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiy.......................qee

CERTLPRSNTSDDEYDACSVYVPDNVGEEL--KFEGVTMKCTDCKKefNDEVEIRVVVVKFDDLkEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASK
..  .   . .. . . |.|| ||. . |.  ....| .| .. ..  ... ..| .|.|     | .  ||||  |     |....|.| |.. |. |.
vqvivmltklkeaneqkCavyfPdaedyeiserygdveikvekive..rndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesr

-------TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIY
       .||.|||  |  |  ||  ...|.. . ..  |        |   |  .  ..| | . |.
eeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyel.ih
subfamily_PTPN23_pd Subfamily PTPN23 810-1039 4.4e-16 53.5 In-house 58-269 (288) alignment 
Range on Protein: 810-1039
Range on HMM: 58-269/288.0
NRVALKgygkRLSDGYIHASFVSF--PSNLCMILTQAPQAKNLGDpyaviriskrnstiekFLWMAMQEGVKHVVQLCERtlprsntSDDEYDACSVYVP
||| |.       | || ||||    |   ..| ||||... |.|                |  | ... .. .| | ..       .. .   .. | |
nRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnD................FWlmvyeqkssviVmllsk.......eelgkpkvdrYwP

DNVGEELKFEGVTMKCTDcKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA--------SKTPVIVHCYDGRSRSACF
 . ||  ||. ... . . ..| .  ||  . .   |  .  .  |  .  | .  .|.||.|.|..|| |..        ||||..|||  |  |.  |
edkgetvkfgdlsvtlks.vretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvf

AYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYA
| .  | . . |.. ..  . .   ..      |...|  
alvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql
subfamily_PTPN3_pd Subfamily PTPN3 863-1047 8.2e-16 52.7 In-house 94-272 (280) alignment 
Range on Protein: 863-1047
Range on HMM: 94-272/280.0
NSTIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPDnVGEELKFEGVTMKCTDCkkEFNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGK
..| ..|  |  .. .. .| | . .       ..    |  | |.  ..||.. . ..||. .  . . .. .| .|.|  .  .| .  .  |  |  
aktatdfWqmvweqksslivmlttlv.......erGrvkChqyWPe.tedeleygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpd

SSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIyGAMM
...|.... .| ... |.. .    .||.|||  |  |.  .  .|.| ... ....|     .. .   ||.|    . | |    |..
hgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvC.eail
PTPc_DSPc_SM00012 952-1043 3e-15 51.7 In-house 3-101 (105) alignment 
Range on Protein: 952-1043
Range on HMM: 3-101/105.0
NHYWYRGWGKSSIPESPKTMLALLDMVNASKT------PVIVHCYDGRSRSACFAYMELACQMVAKN-DSVTSRVALKALMKMRANLFVKDEEYAFAIY
.||.| || . ..||... .| ||. |. .|.      ||.||| .| .|...|. .....|.. |. ..|     .|.|.|.|....  .|.| | . 
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr
0049772 (Phosphotyrosine protein) phosphatases II 794-1074 4.2e-15 51.7 In-house 45-300 (314) alignment 
Range on Protein: 794-1074
Range on HMM: 45-300/314.0
ESHAMDHRAQNALAPgNRVALKGYGKRlSDGYIHASFVSFPsnLCMILTQApqaknlgdpyavirisKRNSTIEKF----------LWMA--MQEGVKHV
. . ..   .   |. ||| |.|.. . . .||.||.|. .  |  | ||.                ... |.. |          . |    .  |  .
lnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf..lkfIatqg................pleitvvdfreepvlyyngwrmvlrgdlnvrdi

VQ---------------------LCERTLPRsntsddeydacSVYVPDNVGEELkfegvtmkctdckK------EFndeveirvvvvkfddlkEFTFNHY
|                      |.. . .            . ... .. .               .       |                 | .  .|
vmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk.............eelydpelf.................erlgiky

WYRGWGKSSIPeSPKTMLALLDMVNA--SKTPVIVHCYDGRSRSAC--FAYMELACQmvakndSVTSRVALKALMKMRA-----NLFVKDEEYAFAiYGA
..  .   | | ... ....|.....   ..||.||| .|..|...  .|.. . ..       |. . ||. ....|      ...   |.| |  . |
lripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll......gvsleealedvrlkRpinpnpgfieqleqyefi.lea

MMRLMEVGKatcrNEFEEYQQWYNEWYQT
.. ...  |    ...| ..... . .|.
lleylkflk....kfyeyleenlldglql
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 810-1047 7.7e-15 49.4 In-house 63-284 (305) alignment 
Range on Protein: 810-1047
Range on HMM: 63-284/305.0
NRVALKGygkRLSDGYIHASFVSFPSNL-CMILTQAPQAKNLGDpyaviriskrnstiekFLWMAMQEGVKHVVQLCertlprsNTSDDEYDACSVYVPD
||| |.|        |||| .|| |.|   .| ||||  |   |                | .| .|. |. .  ||       |  .     |. | . 
nrvkleg...pwpheyihanyvstptnpkrfictqaplektcad................fwymclqdkveaifmlc.......nllekgakkcleyfas

NVGEELKFE----GVTMKCTDC-----KKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACF
. ...|.||     ...|.  .     .|. . .|.  |.|..    |    .|| .  |    .| .  ..| ||    .|| |..|||  |  |.   
kdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsv

AYMELACQ-MVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMM
  .|  .. ..| .    .   |. . . | |    |..| | ..  ..
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylf.vhqvil
subfamily_PTPRK_pd Subfamily PTPRK 863-1056 1.8e-14 48.3 In-house 96-283 (314) alignment 
Range on Protein: 863-1056
Range on HMM: 96-283/314.0
NSTIEKFLWMAMQEGVKHVVQLCERtlpRsntsDDEYDACSVYVPDNVGEelkFEGVTMKCTDCkkEFNDEVEIRVVVVKF---DDLKEFTFNHYWYRGW
..|.. |  .  .|.   .| | |         .     |. | |..      .. . ... ..  | . |. .|.  |.       .  . ... . ||
qetvkdfWrlvydencasivmltel...v....evgrvkClkyWPedtev...ygdikvelvet..ellaelvvrifrveklargqeeirevrqfqflgW

GKSSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKA
 .  .| | ...|.|.  |..|.     ...|||  |  |. .|  ..  ..|. ... |    | |.| . . |.    | | | || ...    .|..
pdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykf.iydvileaclcget

T
.
a
subfamily_PTPN12_pd Subfamily PTPN12 810-1050 4.3e-14 47.1 In-house 55-277 (290) alignment 
Range on Protein: 810-1050
Range on HMM: 55-277/290.0
NRVALKGYGKRLSDGYIHASFVSFPSNLC-MILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPD
.|| |.   .   ..|| |.|.  ... .  | .|.| .|                |.. |  | ..  |. || .|.         . .   |  | |.
srvelskieeeegsdYinanfikgvegkleyiaaqgPLpk................tlddfWrmiweknveivvmaCrev.......elgkkkCerYWpe

NVGEELKFEGVTMKCTDcKKEFNDEVEIRVVVVKFDDlKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA----SKTPVIVHCYDGRSRSACFAYMEL
...|||.|. ....... .| ..|.  || . |.... .. ... . |. |    .|.|.|..|.|...|.     ...|..|||  |  |      ...
egeeelefgefevtlee.ekavdddflirtLkveaqk.esrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidy

ACQMVAKNDSVTSRVALKALMKM---RANLFVKDEEYAFaIYGAMMRLM
. ... ..    .    . ....   || |    | | . .| |.. |.
vrellkaekipeeldvfdlvlelrkqraalvqtkeqyel.vykavaelv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 836-1013 4.4e-14 46.6 In-house 73-252 (302) alignment 
Range on Protein: 836-1013
Range on HMM: 73-252/302.0
NLCMILTQAPQAK--NLGDpYAVIRISKRNSTIEKFLWMAMQEGVKHVVQLCErtlprsnTSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKK---EF
..  |..| |     .. .  .   |  ..||.||.  .  |  |  |||||.         .||   |. |  |.||.||||   |.|  . |.   ||
eikwimaqGpmdGtekkek.vskkpivpkkstlekhwalieqynvaivvqlcs.......fvedeekkcaeyysdkvggelkfgrytvktvsvktdleef

NDEVEIRVVVVKFDDL-----KEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKND
 |  ....  |.. .      ...| .   . .| .   |. ..| | .|   .. |. |.|||  |  |.  .  .    |. .|..
tdkksfklytveiknekkkkkvkktvdilafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkk
subfamily_PTPRD_pd Subfamily PTPRD 863-1084 9.1e-14 46.0 In-house 101-320 (564) alignment 
Range on Protein: 863-1084
Range on HMM: 101-320/564.0
NSTIEKFLWMAMQEGVKHVVQLcertlprSNTSDDEYDACSVYVPDNvGeELKFEGVTMKCTDCKkEFNDeVEIRVVV-VKFDDLKEFTFNHYWYRGWGK
..||| |  | ... .. .| |       ..... . . |. | |.. | . .....| . .... |..| .|||     | .. .  . ... .  |  
aetiedFWRmvweqnsstiVml.......tkleEkgkvkchkYWPek.g.tetygeltVtleeee.elad.yeirtfklkkkkssesreVrqFhFtsWPd

SSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKATC
. .|||....|.|.. |.|..     |..|||  |  |. .|  ..   . . ... |  .  .||| | |  .  . | |.| |. |..  .. |.   
hgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiF.iheailealacgntev

RneFEEYQQWYNEWYQ-------TLFNARKTSLE
.   |...|  ..  .       | ...    |.
e..senlkqhlqkLaeveedtemtgleleFqrLa
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 810-1053 1.1e-13 46.2 In-house 71-293 (298) alignment 
Range on Protein: 810-1053
Range on HMM: 71-293/298.0
NRVALKGYGKRLSDGYIHASFVSfpsnlcmiltqAPQAKNlgdPYAVIRiSKRNSTIEKFLWMAMQEGVKHVVQLcertlprSNTSDDEYDACSVYVPDN
 || |.   .     || |||..           | . .|   .. . .    ..|.| |  | ..| .. .| |        |. . .   .. | ||.
sRvvLekedadeesdYiNAsflh...........aykgrn...afiatq.aPltetvedFWrmvteedigtiVml.......tnleeldktkyhkywPde

VGEelKFEGVTMKCTDcKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASK-----TPVIVHCYDGRSRSACFAYMEL
  |  ... .|..    |.|| | .  .. | | .  || .  .  .  |   ..||  ...|.||. |.||.     .||||.| .|  ||  |  .. 
gke..tygeitvslls.keefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaids

ACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVG
  . | |. .|  . ..|.| | |...    |.|.| || |... .. .
vlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvf.iyeavlealdsf
0046846 (Phosphotyrosine protein) phosphatases II 857-1042 1.2e-13 46.7 In-house 27-166 (176) alignment 
Range on Protein: 857-1042
Range on HMM: 27-166/176.0
IRISKRNSTIEKFLWMAMQEGVKHVVQLCERTLPRS-N------------Tsddeydacsvyvpdnvgeelkfegvtmkctdckkefndeveirvvvvkf
.     ..|...|| |  ..|...|| |.|..   . .                                                              
atqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.................................................

ddlkeftfnHYWYRGWGKSSIPESpKTMLALLDMVNASK---TPVIVHCYDGRSRSACFAYmelaCQMVAKNDSVTSRVALKALMKMRA-NLFVKDEEYA
         .|.. .|   ..|.. . .| ||....       ||.|||. |..|.....     . .. ..  ..   ||. . ..|  . .  .| | 
.........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplgavqtpeQyr

FAI
|  
fly
0044763 (Phosphotyrosine protein) phosphatases II 825-1032 1.9e-13 46.0 In-house 20-154 (178) alignment 
Range on Protein: 825-1032
Range on HMM: 20-154/178.0
YIHASFVSfPSnlcMILTQAPQaknlgdpyaviriskrnstiEKFLWMAMQEGVKHVVQLCERTLPRSNTsddeydaCSVYVPDNVGeelkfegvtmkct
||.||..  |    ..|...|.                    ...| .  ..|..|.| |.| . .  .        |  | |.. |             
yinaseil.pg...lylgslpp....................addlellkelgithivnlteelelgflk.......cdpywpeeag.............

dckkefndeveirvvvvkfddlkeftfNHYWYRGWGKSSIPESPKTMLALLDMVN----ASKTPVIVHCYDGRSRSACFAYMELACQMvakndSVTSRVA
                            .| . ..  .. |.... .|.......     .. ||.|||. |..||.... . | ...     ...   |
...........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleea

LKALMKMRAnLF
.. . ..|   .
ielvrerRp.iv
0036282 (Phosphotyrosine protein) phosphatases II 824-1029 2e-13 45.9 In-house 3-150 (174) alignment 
Range on Protein: 824-1029
Range on HMM: 3-150/174.0
GYIHASFVSFPSNL-CMILTQAPQAknlgdpyaviriskrnstiekFLWMAMQEGVKHVVQLCERTLPRSNTSDDEYDAcsvyvpdnvgeelkfegvtmk
 ||.||....   .   |..|.| |                     |. |  ..|...||.|.|   . .    . .                       
dyinaspldlsyitprliagqgpla.....................fwemlkelgittvvmlleekelglykcinywpe.....................

ctdckkefndeveirvvvvkFDDLKEFTFNHYWYRGWGKSSIPESPKtMLALLDMVNAS-----KTPVIVHCYDGRSRSACFAYMELACQMVAkndsVTS
                    . .  | .  .|.| .|   . |.... .| ... |.       . ||.|||  |..|..... . | ...       . 
....................lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....esl

RVALKALMKMR---A
. ||. . ..|    
vdaldlvrelRlqrp
subfamily_PTPRB_pd Subfamily PTPRB 810-1053 2.9e-13 44.5 In-house 66-288 (293) alignment 
Range on Protein: 810-1053
Range on HMM: 66-288/293.0
NRVALKGYGKRLSDGYIHASFVS-FPSNLCMILTQAPQAKNLGDPYAVIrISKRNSTIekflwMAMQEGVKHVVQLCERTLPRSntsddeydacsvyvpd
.|| |.   .. .. || |.... . |.   | || |  . . | . ..   |. |.|     . . . | .  . ||.  |.                 
srvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmv.wekkssii.....vmltqlvekgkvkCeeYWPad................

nvGEELKFEGVTMKCTdcKKEFNDEVEIRVVVVKFdDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVN------ASKTPVIVHCYDGRSRSACFAYM
   |.  .  .... .  ..|  ..  || . ..  . .| . ..| .  |    .||..||.|... .|.      |||.|..|||  |  |.  |  .
..eepvlyGdikvtlv..aeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial

ELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVG
.   | . ..| |     . .| . |..|    ..| | |. ....|.. .
drllqaieeedyvdifgivaelReeRnllvqtekqYif.ihqcvldllrkk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 786-1055 3.8e-13 44.2 In-house 38-288 (319) alignment 
Range on Protein: 786-1055
Range on HMM: 38-288/319.0
LTFNTRWVESHAMDHRAQNALA-PGNRVALKGYGKRLSDGYIHASFV-SFPSNLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQ
 ||..   |      | || ||    ||.|. .    .  || |||. ..  .   | |||| ..                ||| |  |  .|..  || 
dtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen................tiedfWrmvWeeessivvm

LCERtlprsntSDDEYDACSVYVPDNVGEElkfEGVTMKCTDCKKEfNDEVEIRVVVVK--FDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNAS
|..        ..     .. | |..  ||    |  .   . ..|  ....|| . ..   ....  .  |. |  |    .||. ...|.||  .. |
ltkl.......veklkvklkkywpeenfee...yGrlivtleeeee.ledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

-----KTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKA
     . |..||| .|  |   |  .. . . | ..  .      . |   |  .  . | | | || |..  .|.|..
rektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkf.iyealleaveagdt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 810-1055 4.1e-13 44.1 In-house 63-293 (325) alignment 
Range on Protein: 810-1055
Range on HMM: 63-293/325.0
NRVALKGYGKRLSDGYIHASFVS-FPSNLCMILTQAPQAKNLGDPYAVIRISKrnstiekflwmamqegvkhvvqlCERtLPRSNTSDDEYDACSVYVPD
.|| |.  ..  |  || ||..  .     .. .|||... ..| . ..   .                       |   .   |  | . | |.|| |.
srvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.......................csv.vvvlneldlgkdrcavywpk

NVGEELKFEGVTMKCTDCkKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA----------SKTPVIVHCYDGRSRSAC
..|.  .| |. .|     .|. | |  .. | . .. .  . . . ...|     .. | |....|..|.|          . ||..||| .|  |.  
emgksktfGglevklrti.eeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

FAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKA
|. .  | . | .. .|     .| | | | ..    ..| . || |..  .  |..
fislysalakvieesrvdifgfvkklrkdrpsmvetvdqyil.iyealveaymsgnt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 861-1088 4.8e-13 43.5 In-house 90-311 (312) alignment 
Range on Protein: 861-1088
Range on HMM: 90-311/312.0
KRNSTIEKFLWMAMQEGVKHVVQLCErtlprsnTSDDEYDACSVYVPDNVGE-ELK-FEGVTMKCTDCK--KEFNDEVEIRV--VVVKFdDLKEFTFNHY
  ..|. .|  .|.  |   .. ||          .|  . |. |. | ||  .|.     |  ||. .     .| .  ||  ||||    .|  .|||
plentcthfwqlalslgstsiillcg.......fvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvka.tgqesklnhy

WYRGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAIYGAMMRLMEVGK
 .  |    .|.|  | | ||  |.  | ||| ||  |  |.  .| .|     . .      . ..  | | ||       .| .|.   .  |.  | 
qwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

aTCRNEfEEYQQwYNEWYQTlFNARKTSLEEKAK
   ||| .|. . ..| |    .|.|  ...|..
.ykrne.qewtk.fketyak.ikakklkikdksr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 863-1032 5.1e-13 43.6 In-house 85-253 (285) alignment 
Range on Protein: 863-1032
Range on HMM: 85-253/285.0
NSTIEKFLWMAMQEGVKHVVQLCerTLprsntSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFND-EVEIRVVVVKFDDLK--EFTFNHYWYRGW
  |.  |  |  || . .|. ||  ||      .   . |..| |...|| .||    .  |.||.|     .   . |.. .|     . .||     |
petlsdfwhmiyqekiayvlmlc..tl.....feggvekcalyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpww

GKSSIPESPKTMLALLD---MVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLF
     ||  . |. |      ||  ..|. |||  |  |.| |  .. |   . .|  .     .. .  || .  
pdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenpniemldivremramrfqav
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 862-1048 1.4e-12 42.1 In-house 96-275 (315) alignment 
Range on Protein: 862-1048
Range on HMM: 96-275/315.0
RNSTIEKFLWMAMQEGVKHVVQLCERtlprsntSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKeFNDEVEIRVVVVKFDDLKEFTfnHYWYRGWGK
 ..... |  | .|| |  .| . ..       ....   |  | ||. ..  .|  . ..  . .    | |  ..|. | .. .  |   . ...| .
lkasvddfwrmvlqekvttivmvtkk.......qegdkikcrqywPdrkadsvefGsikvellslea.dtdgvarklvtrkseesrtvt..qfqftewPd

SSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMR
  ...   ..| |.  | |..     ...|||  |  |.  .  ..   . .....||     .| | . |  |   .||||| ||.|.. 
kGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyaf.iydavle
0049260 (Phosphotyrosine protein) phosphatases II 863-1038 1.4e-12 43.1 In-house 19-139 (152) alignment 
Range on Protein: 863-1038
Range on HMM: 19-139/152.0
NSTIEKFLWMAMQEGVKHVVQLCERTLPRSNTSDDEYdacsvyvpdnvgeelkfegvtmkctdckkefndeveirvvvvkfddlkeftfnHYWYRGWGKS
. |...|. |  . |....| |.|..       .  .                                                     .| .  |  .
pntladfwrmlkelgittivmltellelgklkceqyi.....................................................qylhlpwpDh

SIPESPKTMLALLDMV----NASKTPVIVHCYDGRSRSACFAYMELACqmvaknDSVTSRVALKALMKMRANLFVKDEEY
. |...  .| ||...      .. ||.|||. | .|..... . | .        |.   |.. . ..| . .   . .
gvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgql
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 864-1052 1.5e-12 42.2 In-house 63-244 (250) alignment 
Range on Protein: 864-1052
Range on HMM: 63-244/250.0
STIEKFLWMAMQEGVKHVVQLcertlprSNTSDDEYDaCSVYVPDNVGEelKFEGVTMKCTDcKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSS
.|||.|  | ..| .. .| |       .| .. |   .. | | .. |  |. .||..  . |.|| | .  .... |    .| .  .. .  |   .
atiedfWrmvleeksgtivmL.......tnLkesekt.yhqywPvekae..kyGdvtvslls.keefadytkrklklskakkaderivrqlhfvvWPdkg

IPESPKTMLALLDMVNASK-----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEV
.||  ...|.||. |.||.     .||||.|  | .|| .|  ..   . . |.  |  .  .|.| | | .     | | | .| .... .. 
vPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf.vyeiilkalds
subfamily_egg_pd Subfamily egg 811-1074 2.1e-12 41.3 In-house 56-294 (307) alignment 
Range on Protein: 811-1074
Range on HMM: 56-294/307.0
RVALKGYGKRLSDGYIHASFVSFPS-NLCMILTQAPQaKNlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCERTLPrsntsddeyDACSVYVPDN
||.|.    . .| .|||  |.       .||.|||  ||               | . |  | .|| |...| |  |  .         . |  | |  
rvklelrrGqylddfihanrvkGkpllnefilaqapl.kn...............tvddfwrmvfqeevqyivmltsrkes.........erceyywpka

VGEELKF--EGVTMKCTDCKKEFNDEVEIRVVVVKFDDlKEFTFNHYWYRGWGKSSIPESPKTMLALLDmvNASkTPVIVHCYDGRSRSACFAYMELACQ
  . |..   .. ... . ... .    .  . .   | .|  |  .|   . .||   ||  .| .|   |.| .||.|....| |..|..  .|.|  
esdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwqgdvnnssdvysplrvlrklr..nls.kpvvvqdilGvskaatlvaieiall

MVAKNdSVTSRVALKALM--KMRANLFVKDEEYAFAIYGAMMRLMEVGKATCRNEFEEYQQWYNEWYQT
 . .   .|  . |.| .  ..| .| |.     . .|  .. ..    .....   .|..| .|  . 
sllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldvdyerwleersek
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 862-1047 1e-11 38.6 In-house 95-273 (515) alignment 
Range on Protein: 862-1047
Range on HMM: 95-273/515.0
RNSTIEKFLWMAMQEGVKHVVQLCERtlprsntSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKkEFNDEVEIRVVVVKFDDLKefTFNHYWYRGWGK
 ..... |  . .|| |  .. . ..       ....   |. | ||  |. .||  . ..    .    . .  .. |.| || .  |   . . .| .
nkasvddfWrlvlqenvttiamvtkl.......kegdkikcgkyWPdkpgdsvkfGsikvelvsle.actggikrkltvlkgddsr..tvtqfhfteWPd

SSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMM
  .|.  ...| |.  | |..     |.|.||  |  |   .  ..     ... ..|     .. . . |  |   .|.||| ||||..
kGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyaf.iygavl
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 820-1010 1.1e-11 38.9 In-house 63-228 (281) alignment 
Range on Protein: 820-1010
Range on HMM: 63-228/281.0
RLSDGYIHASFVSFPS-NLCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCERTlprsntsDDEYDACSVYVPDNVGEELKFEG
. |  |||| ..  |  .   |||| |.                . |   |  |  ||    .| ||. .       . . . |. |.| |    |.|. 
knstdyihanyirspflkrgyiltqgpk................ketradfwrmiwqenttaivmlcqfl.......etnrekcaeyfprnahcclqfdk

VTMKCTDCKKEfNDEVEIRVVVvKFDDLKEfTFNHYWYRGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVA
....  |   . .  |  |. .  ..        |. .. |    .||| . || .|  . |  || ..||  |  ||  .  .|.| | . 
lsvsyedstvn.kslvttrlnl.syegetr.lithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsih
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 810-1065 1.3e-11 39.5 In-house 40-271 (284) alignment 
Range on Protein: 810-1065
Range on HMM: 40-271/284.0
NRVALKG-YGKRLSDgYIHASFVS-FPSNLCMILTQAPQAKNLGDPYAVIRISKrNSTIEKFLwmamqegvkhvvqlcertlprsntsddeYDACSVYVP
|.| |.   |.  || || |||.. . ..   | || |.   | | . .|  ..  |||  .                              | || | |
nvvklerliGeefsd.yinasfitGyqrkdkyiatqGPldntladfWrmiweyn.cstivllt............................kdkcsqywp

DNVGEELKFEGVTMKCTDCKKEFNDeVEIRVVV-VKFDDLKEftFNHYWYRGWGKSSIPESPKTMLALLDMV------NASKTPVIVHCYDGRSRSACFA
 .. .. .   | ..  .  .|.    .|..    |  | ..   . . ..|| .   |..|  ...|.. |      .  .....|||  |  |.  . 
lkivikeerfkvkvdsveeseeyvv.rdielsedgkekdirk..irqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

YMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKAT-CRNEFEEYQ
 ..   ... ... |     .. | . | .|  .  .| | || |..    .|..  .  .|  | 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf.iysalleehlfghsdvalpdfpayl
0048076 (Phosphotyrosine protein) phosphatases II 945-1042 1.5e-11 39.7 In-house 41-136 (145) alignment 
Range on Protein: 945-1042
Range on HMM: 41-136/145.0
DLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNAS---KTPVIVHCYDGRSRSACFAYMELACQmvaknDSVTSRVALKALMKMRANLFVKDEEYAFA
.| | .  .|.| .|   ..|......|..|.....    . ||.|||. |..|..... . |  .      .|.   ||. . ..| . .  .. . | 
ellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrfl

I
.
y
subfamily_PTPN1_pd Subfamily PTPN1 864-1029 1.9e-11 38.2 In-house 82-248 (290) alignment 
Range on Protein: 864-1029
Range on HMM: 82-248/290.0
STIEKFLWMAMQEGVKHVVQLcERTLprsntsDDEYDACSVYVP-DNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKFDD-LKEFTFNHYWYRGWGK
.|.. |  |  ..  | || | .. .      . |   |  | | ..  .||..| ...| .  ..| ...  .|.. ..     .  .  |. |  |  
ntvdhfWqmvWeqkskavvml.nkvv......ekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpd

SSIPESPKTMLALLDMVNAS------KTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRA
 ..|||| ..| .|  |  |      . |...||  |  ||  |. ..     . |.| ..|    | |...| 
fgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 810-1056 2.1e-11 38.7 In-house 76-297 (319) alignment 
Range on Protein: 810-1056
Range on HMM: 76-297/319.0
NRVALKG-YGKRLSDgYIHASFVS-FPSNLCMILTQAPQAKNLGDPYAVIRISKrNSTIEKFLwmamqegvkhvvqlcertlprsntsddeYDACSVYVP
|.| |.   |.  || || ||||. . ..   | .| |.   | | . .|  ..  |||  .                              | || | |
nvvklerliGeefsd.yinasfvtGyqrkdkyiaaqGPldntladfWrmiweyn.cstivllt............................kdkcsqywp

DNVGEELKFEGVTMKCTDCKKEFNDeVEIRVVV-VKFDDLKEftFNHYWYRGWGKSSIPESPKTMLALLDMV------NASKTPVIVHCYDGRSRSACFA
 .. .. .   | ..  .  .|.    .|..    |  | ..   . . ..|| .   |..|  .. |.. |      .  .....|||  |  |.  . 
lkivikeerfkvkvdsveetaeyvv.rdielsedgkekdirk..itqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyi

YMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKAT
 ..   ... ... |     .. | . | .|  .  .| | || |..    .|.. 
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykf.iysalleehlfghsd
0048179 (Phosphotyrosine protein) phosphatases II 905-1039 3.1e-11 38.7 In-house 48-135 (144) alignment 
Range on Protein: 905-1039
Range on HMM: 48-135/144.0
YvpdnvgeelkfegvtmkctdckkefndeveirvvvvkfddlkeftFNHYWYRGWGKSSIPESPKTMLALLDMVNAS---KTPVIVHCYDGRSRSACFAY
.                                               .|.. .|   ..|.... .|..|.....    . ||.|||. |..|..... 
e.............................................giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlva

MELACqmvaKNDsVTSRVALKALMKMRANLFVKDEEYA
. |      |.. ..   ||. . ..| . .  .. . 
aylmk....klg.lsleealalvrsrrpgavpnpgqlr
subfamily_PTPRG_pd Subfamily PTPRG 864-1059 3.2e-11 37.1 In-house 102-296 (563) alignment 
Range on Protein: 864-1059
Range on HMM: 102-296/563.0
STIEKFLWMAMQEGVKHVVQLcertlprSNTSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFN-DEVEIRVVVVKFDDL--KEFTFNHYWYRGWG
.|.. |  |  .. |. .| .       .|  ...   | || | .  |...   ||.. .. .   .  .. |. . .|  .   .| .  .| |  | 
dtfddFWrmiWeqnvaiivmi.......tnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP

KSSIPESPKTMLALLDMVNASK----TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKAT
  . ||..   |      .|..     |..|||  | .|.  .  ..   . . ....|     || .  .| .|. . |.| | .. |.. ..  ..  
dhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYif.lhdalleaiaskete

CRN
  .
lla
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 794-1022 3.7e-11 37.4 In-house 44-256 (290) alignment 
Range on Protein: 794-1022
Range on HMM: 44-256/290.0
ESHAMDHRAQNALAP-GNRVALKGYGKR--LSDGYIHASFVS-FPSNLCMILTQAPQAKNLGDPYAVIriSKRNSTIEKFLWMAMQEGVkhvvQLCERTL
.|     | .| . .  ||. |.  ...   .. ||.|...  .  .   |.||.|  . | | . .|   ....||   |   ..||     . |    
ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkli..wqekvtiivmltniieegk....vkCqqYW

PRSNTSDdeYDACSVYVpdnvgeelkfegvtmkctdCKKEFNDEVEIRVVVVKFDD--LKEFTFNHYWYRGWGKSS-IPESPKTMLALLDMVN----ASK
| |.|..  |.  |. .                    . |  .|  .| . || ..   .. .  .|    | .   ...    .|..  |..      .
pdsdtka..ygefsikl...................lneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgn

TPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALK
|...||| |. .||| |  .. . . . ..  .     ||
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 861-1038 4.6e-11 37.3 In-house 90-266 (307) alignment 
Range on Protein: 861-1038
Range on HMM: 90-266/307.0
KRNSTIEKFLWMAMQEGVKHVVQLCERtLPRSNTsddeydACSVYVPDNVGEELKFE----GVTMKCTDCKKEFNDEVEIRVVVVKFDD-LKEFTFNHYW
 ...|. .|  ||.|| |. |. ||.  .  ..        |  | | . |..| |      ....   .||   ||  | |  .| |   |  | .|. 
plentqysfwamaiqekvesvimlckv.ielaki......kceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlq

YRGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMEL-ACQMVAKNDSVTSRVALKALMKMRANLFVKDEEY
.  |    .|.   | . ||. |.  . ||.|||  |  ||     . |   .|.|  .    .  .. | . |     .. .|
wenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy
subfamily_PTPN13_pd Subfamily PTPN13 899-1050 5.9e-11 37.2 In-house 116-269 (273) alignment 
Range on Protein: 899-1050
Range on HMM: 116-269/273.0
YDACSVYVPDNVGEELKFEG-VTMKCTDCKKefNDEVEIRVVVVK-FDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVN---ASKTPVIVHCYDGR
   |  | |.. ...|| .. ....  . .|   |.  .| . ||  .  .     |  .  |   ..| |.. .| ..  |.    ...|..|||  | 
kvkchrywPesknkklkvsnrlevellkvqk..ldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGi

SRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLM
 ||  .  .. . ...... ..  .  .. | . |  .   .. | | .| |.. ..
GrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyif.vykailevl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 800-1051 6e-11 37.0 In-house 45-277 (281) alignment 
Range on Protein: 800-1051
Range on HMM: 45-277/281.0
HRAQNALAP-GNRVALKGYGKRLSDGYIHASFVS-FPSNLCMILTQAPqaknlgdpyaVIriskrnSTIEKFLWMAMQEGVKHVVQLCERtLprsntsDD
.| .|  |    || ..   .  .  || |.||. . ..   | ||.|          |       .....| .| ... |. .| . .  .      . 
nrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgP..........vP......aslvafWqmvweqkvsaivmvtre.i......ea

EYDACSVYVPDNVgEELKFEGVTMKCTDcKKEFNDEVEiRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMV-----NASKTPVIVHCYDG
.   |  | ||.  .|||.  ||.| |  ..| .  .| |.. .. .. .. . ..  |  |    .|...| .|   . |     . .|.|...||  |
gklkChrYWPddn.selkygdvtvksta.eeekatyie.rkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaG

RSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVK-DEEYAFaIYGAMMRLME
  |. ..  .. ... |... . ..  |. | .. . ||.|.    |.| .| |... ..
vGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyef.vykavldald
subfamily_PTPN6_pd Subfamily PTPN6 863-1050 7.4e-11 36.6 In-house 108-297 (306) alignment 
Range on Protein: 863-1050
Range on HMM: 108-297/306.0
NSTIEKFLWMAMQEGVKHVVQLCertlprsNTSDDEYDACSVYVPDNVGEELkFEGVTMKCTDCkkEFNDEVEIRVVVVK--FDDLKEFTFNHYWYRGWG
..|.. |  |..||  . .| .        .  .   . |. | ||.  .|  .  .......   . ... ..| ..|.   .. .| .  .| .. | 
ettvsdFWrmvwqensrvivmtt.......kevErgkekCarYWPdeeekee.yGkisvtnvse..ksladYilRelsvskkkkkkeerevfqyhfksWP

KSSIPESPKTMLALLDMVNAS--------KTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVT---SRVALKALMKMRANLFVKDEEYAFaIYGAMMRL
  ..|..|...|..|. ||.         . |..||| .|  |   |  ...  ... |.   .    . . | . . |  |   .. | | .| |.   
dhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykf.vykaikky

M
.
i
subfamily_PTPRN_pd Subfamily PTPRN 810-1042 9.8e-11 35.9 In-house 71-285 (297) alignment 
Range on Protein: 810-1042
Range on HMM: 71-285/297.0
NRVALKGYGKRLSDGYIHASFVS--FPSNLCMILTQAPQAknlgdpyaviriskrnSTIEKFLWMAMQEGVKHVVQLCErtlprsnTSDDEYDACSVYVP
.|| ||   .. .. || ||..    | . . | ||.| |                ||. .|  |  ..||  .|.|..        ....  .|. | |
srvklkeeasaeksdyinasaildhdprapayiatqgpla................stvadfwqmvweqGvvvivnltr.......leeegvkqckrywp

DNVGEELKFEGVTMKCtdcKKEFNDEVEIRVVVVKF-DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNAS----KTPVIVHCYDGRSRSACFAYM
|.  |  ..  | .     .. . |.  .|   .|  .  .  |   . .  | ....| |.|..| .   || |     .|..|||.||  |. ..  .
deGsevyhiyevhlvs...ehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyili

ELACQMVAKND-SVTSRVALKALMKMRANLFVKDEEYAFAI
.| .. ..|    .    .|. |   |..|    ... ||.
dlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefal
subfamily_CG7180_pd Subfamily CG7180 861-1047 1.1e-10 35.7 In-house 93-287 (296) alignment 
Range on Protein: 861-1047
Range on HMM: 93-287/296.0
KRNSTIEKFLWMAMQEGVKHVVQLCertlprsNTSDDEYdACSVYVPDNVgeELKFEGVTMKCTDCKKEFNdEVEIRVVVV----------KFDDLKEFT
 ...|...|  .  .|... || |.       .| | .   .  |.| .   . ..  . .. .  |.  |  .   . ..          |  . .. .
pkketvdefWrlvydeeisavvvLt.......ktfdfak.mypsywpnks..keqygeifveiveekqyan.lkirtfkltkkivalteqekqvkaetRi

FNHYWYRGWGK-SSIPESPKTMLALLDMVNA---------SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAF
  .. .. |    ..| | .... |. .|.           . ||.|.. ||.|||  .  .. . ..| |.. |    |.| | . | .|  . ||| .
vklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYky

aIYGAMM
 ||  . 
.iYdvll
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 865-1059 2.2e-10 35.0 In-house 104-288 (315) alignment 
Range on Protein: 865-1059
Range on HMM: 104-288/315.0
TIEKFLWMAMQEGVKHVVQLcertlprSNTSDDEYDACSVYVPDNvgeELKFEGVTMkcTDCKKEFNDEVEIRVVVVKFDD-LKEFtfNHYWYRGWGKSS
... |  . ..| . ..| |       .|. ..|   .  | ||.   .. .  .|.  |  ..| |.|. .| . | |.| ..|     . |  | .. 
svkdfwrlvfeedigkivml.......tnlvegekrkaekywpdk...kviyGkitv..trkseevnteytvrtlsvvfgdnirev..vqlhytswpdmg

IPESPKTMLALLDMVN----ASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKATCRN
.|..  ... |   |.    .| ....||| .|  |.  |  ..   . .  .. .    ... . ..| ..    |.| | || |..  . .| ..  .
vpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqf.iydalletfvcgdtsiaq
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 801-1047 1.6e-09 32.3 In-house 56-281 (297) alignment 
Range on Protein: 801-1047
Range on HMM: 56-281/297.0
RAQNALA-PGNRVALKGYGKRLSDGYIHASFVSFPSNlCMILTQAPQaknlgdpyaviriskrNSTIEKFLWMAMQEGVKHVVQLCErtlprSNTSDDey
| .| |    .|| |.  ..  .  |. ||||    .  .| || |.                ..|.. |  | ..| |. .| | .      | .|.  
RYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPm................katvadfWamvldeqvstivmlnd.....dnerdk..

dACSVYVPDNVGEElkFEGVTMKCTdCKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPE--SPKTMLALLDMVNA-----SKTPVIVHCYDG
  |  | .|.   .  |  |... . . .| .  ..  ..| | .  ..   . | .  | . ....  | ...| |.. |.      ...|..|||  |
.kcaryWsdkgvtt..fGdvsvvll.svsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaG

RSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMM
  | . .  ..     . ....|     .| | . | .|   .|.|.| .| |..
vGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykf.vyvavl
subfamily_PTPRA_pd Subfamily PTPRA 893-1055 2e-09 31.8 In-house 134-300 (330) alignment 
Range on Protein: 893-1055
Range on HMM: 134-300/330.0
NTSDDEYDACSVYVPDNvGeELKFEGVTMKCTDCKKefNDEVEIRVVVVK-FDD----LKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASK----T
.  . . . |  | ||. |  . .  ....  |..     .. .| ..|.   |     |.   . . ...| .  .|  |. || ||  |.. .     
elkerkeekcaqywPde.G.lvtyGnirvevedetv..lvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

PVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKA
|..|||  |  |.  |  ..   ..|  .  |    ..| | . |...   || | | || ...     | .
pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef.iykvlleyylygdt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 804-1050 5.6e-09 30.1 In-house 49-293 (301) alignment 
Range on Protein: 804-1050
Range on HMM: 49-293/301.0
NALAPGNRVALKGYGK--RLSDGYIHASFVSFPS-NLCMILTQAPQAKNLGDPYAVIRISKRNStIEkfLWMAMQEGVKHVvqlCERTLPRSNTSDDEYD
..  . ||. ||   .    .  || ||...  | .   | .|.|  | | | . .|   |  | |     . ..|| |.    ||.  |.|.....|. 
itvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvs.iv..mvtnlkegtksk...ceqywpnseaeseefg

ACSVYVPD-NVGEELKFEGVTMKCTDCKkefNDEVEIRVVVVKFDDlKEFTFNHYWYRGWGKSSIPESPKTMLALLDMV-----NASKTPVIVHCYDGRS
  .| . . .|  .     ...| .|     |.   .| . || |  .  .   .    | .  .   |.|.|  .| |       .. ||.||| |. |
pftvtlvneqvyPdfvirqlnvkiqdgs...nngyierkfkvksdk.sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVs

RSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAfAIYGAMMRLM
||  .  ....   .  .  |      ||. . .       | |   || .. . .
rsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqyt.siydvidmyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 795-1031 1.7e-08 28.7 In-house 32-247 (283) alignment 
Range on Protein: 795-1031
Range on HMM: 32-247/283.0
SHAMDHRAQNALA-PGNRVALKGYGKrlsdGYIHASFVSFpsnlcmiltqaPQAKNLGDPYaVIRISKRNSTIEKFLWMAMQEGVKHVVQLcertlprSN
 .    | |. ..   .|| ||   .     || |.|.              . .. .  | .|  |  . |.  |  |  .| .  .| |       ..
enkrknrnqeivpadqwrvelksesr....dyinavfipv...........sksykqdkky.iiaqsPldrtvvdfWkmvfdekitaivml.......tk

TSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFndevEIRVVVVKFD--DLKEFTFNHYWYRGWgKSSIPESPKTML-----ALLDMVNASKTPVI
  .|.  .|| | | .  |.     ||..    .. |     |. .... .    ...   || . .|  .  ....   |           .  |.|..
lqedlrikCsqyWPkrGsedyGeftvtlrkettsnsf....iikelllrvnssakstlllahyqvidW.leygeqaiinslvkfnkvislqteskkgPiv

VHCYDGRSRSACFAYMELACQMvAKNDSVTSRVALKALMKMRANL
|||  |  |.| |  .  . .  |. .||    |    |. .   
vhCstgiGrtavfiaasasvkd.altesvvdvfavvkimreqrmm
subfamily_PTPN14_pd Subfamily PTPN14 785-1048 2.1e-08 28.5 In-house 38-294 (300) alignment 
Range on Protein: 785-1048
Range on HMM: 38-294/300.0
ALTFNTRWVESHAMDHRAQNALA-PGNRVALKGYGKRlSDGYIHASFVSFPSNlcmiltqaPQAKNlgdpYAVIRiSKRNSTIEKFLWMAMQEGVKHVVQ
  ...|  ..  |   | .. |    ||| |.   .  |.||| || .. .           . ..    | | . .  . |...|  |  ..||. .|.
dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvg........gkers....yivaq.gPleltvqdfWqmvWeqgvqlivm

LCERtlprsntSDDEYDACSVYVPDNVG--EELKFEGVTMKcTDCKKEFNDEVEIRVVVVKFDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA-
| |         .|  . .  |.|..    ....|.   .  |  ... .  . . . .  .   .| |  |  |  | .  .|| .|..|  |..|.. 
ltee.......eedgkeksfkyfPkleskkktvefgkfkvt.tkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsv

------------SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMR
            || ||.||| .|  |.      .|  . . .|...  . .|. | . |  |      | | .| ....
rrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkf.vYkvlik
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 895-1056 6.2e-08 27.1 In-house 124-286 (318) alignment 
Range on Protein: 895-1056
Range on HMM: 124-286/318.0
SDDEYDACSVYVPDNVGeeLKFEGVTMKCTDcKKEFNDEVeIRVVVVKFDDLK-EFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASK-----TPVIVH
..   . .  | |..     ... .... .. ..|..| | .| . |. .. . . .   | |  |  ...|||. ..|.|.  |.. .     .|..||
eergkakvhryWPskgs..rsygklvvelke.evelsdyv.lrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMMRLMEVGKAT
|  |  |   |  ..   . ....  |      | | . |  .   .. | | || ...  .. |.. 
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyef.iydvllealasgdte
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 809-1047 1.9e-07 24.8 In-house 59-233 (392) alignment 
Range on Protein: 809-1047
Range on HMM: 59-233/392.0
GNRVALKGYGKRLSDGYIHASFV-SFPSNLCMILTQAPQAKNLGDPYAVIrISKRNSTIEkfLWMAMQEGVkhvvqlcertlprsntsddeydacsvyvp
 .|| |.       . |. ||.. || .. ..| .|.|.|  | | . ..   .. .||   .   ..||                              
sarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmv.fqenvttia..mvtklkegd.............................

dnvgeelkfegvtmkctdckkefndeveirvvvvKFDDLKEFTfnHYWYRGWGKSSIPESPKTMLALLDMVNASK---T-PVIVHCYDGRSRSACFAYME
                                  | || .  .   . .  |  . .|.   ..| ..  |.|     | |.|.||  |  |..    ..
..................................kgddartva..qfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

LACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFaIYGAMM
       |   |     .  . . |  .   .|.||| ||||..
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyaf.iygavl
PTPc_motif_SM00404 944-1018 2.8e-07 25.5 In-house 42-116 (140) alignment 
Range on Protein: 944-1018
Range on HMM: 42-116/140.0
DDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSR
.  ..|.. ... .  .|. . .  . .|. .. ...... |.|||. | ||||... ..| ...  . ... . 
kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayef
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 801-1012 1.3e-06 22.6 In-house 52-241 (287) alignment 
Range on Protein: 801-1012
Range on HMM: 52-241/287.0
RAQNALAP-GNRVALKgygkRLSDGYIHASFV-SFPSNLCMILTQAPQAKnlgdpyaviriskrnsTIEKFLWMAMQEGVKHVVQLCERtlprsntSDDE
| .. | |  .|| ||       . || |.|. .. ..   |....| ..                |. .|  .  .. |. .| ||.         ...
Rltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfn................tarnfWkliddrnvtaivmlcqe.......kend

YDACSVYVPDNVGeeLKFEGVTMKCTDckKEFNDEVEIRVVVVKFDD--LKEFTFNHYWYRGWGKSS-IPESPKTMLALLDMVN----ASKTPVIVHCYD
 ..|  | |..    . .   ... ..  .| |... .| . || ..   .. . . | .  | .   ..|    .| . .|.      ..|...||| |
eevcyqyWpeeks..vvlGeynielln..eevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsd

GRSRSACFAYMELACQMVAKN
.  ||| |  .. . . . ..
tvGrsamfcaaattinkckte
subfamily_PTPN9_pd Subfamily PTPN9 899-1042 2e-06 22.1 In-house 124-283 (297) alignment 
Range on Protein: 899-1042
Range on HMM: 124-283/297.0
YDACSVYVPDNVGEELKFEGVTMKCTDckKEFNDEVEIRVVVVK-FDDLKEFTFNHYWYRGWGKSSIPESPKTMLALLDMVNA-----------------
   |. | |.. ..  .|  ....  .   | ... ..||...|  .. .. .  |. . .|    .|.| ...| .|..|                   
rlkcgqyWpleeessaefgdlsvsnve..veeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghp

SKTPVIVHCYDGRSRSACFAYMELACQMVAKNDSVTSRVALKALMKMRANLFVKDEEYAFAI
|. |..|||  |  |.  |. .... . . . . |  . ..| | . ||     .| |.|  
sgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcy
subfamily_CG42327_pd Subfamily CG42327 854-981 4.1e-06 20.7 In-house 74-193 (319) alignment 
Range on Protein: 854-981
Range on HMM: 74-193/319.0
YAVIRISKRNSTiEKFLWMAMQEGVKHVVQLCErtlprsnTSDDEYDACSVYVPDNVGEELKFEGVTMKCTDCKKEFNDEVEIRVVVVKFD-DLKEFTFN
|   ..|  .|.  .|  .  .   . .|||..        |.   . |. |.| . . . .     .. |  ..| .|.  |  ...|   . .     
yiaaqvsledss.sdfwrtvweqqsrvivqltd.......lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelt

HYWYrGWGKSSIPESPKTMLALLDMVNAS
||||  | .. .| ......|.|  |..|
hywy.kwleaevPaeeaaliamllevrss
DSPc Dual specificity phosphatase, catalytic domain 961-1026 5.3e-06 21.3 Pfam-A 52-112 (133) alignment 
Range on Protein: 961-1026
Range on HMM: 52-112/133.0
KSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELacqMvaKNDSVTSRVALKALMK
.. | .  . . . .. . ...  |.|||. | ||||... . |   |  | ...... |.... .
etkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl...m..ktknlslneAyefvke
DSPc Dual specificity phosphatase, catalytic domain 961-1026 5.3e-06 21.3 In-house 52-112 (133) alignment 
Range on Protein: 961-1026
Range on HMM: 52-112/133.0
KSSIPESPKTMLALLDMVNASKTPVIVHCYDGRSRSACFAYMELacqMvaKNDSVTSRVALKALMK
.. | .  . . . .. . ...  |.|||. | ||||... . |   |  | ...... |.... .
etkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYl...m..ktknlslneAyefvke