Gene Y22D7AR.7 in Caenorhabditis elegans

Synonym: CELE_Y22D7AR.7, Y22D7AR.7

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf1
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP212_AA protein Get Run
CeleP212_AA_445-706 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 440-734 2e-118 389.8 In-house 2-289 (290) alignment
Range on Protein: 440-734
Range on HMM: 2-289/290.0
TSKSPTEVLKEyvtkllakdsekiksvgmTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGLQLILTQSPLHKI-LDKASTVFKF
.||..|.||..                  |||||||...||.|.|||.||||.|...|.|...|..||||..|||||.|||||||..||  ...||..||
rskestavllk..................tdyvkkhemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekf

WWAVRQERVTHIVMLGQVNEEDANWNRMFCK-YFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKL
||...||.|...|||....|..||.... |. |.|||.....|..|....|...|...|||.|.|||....|.||||||.|.|.|....|.|..||||.|
wwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsl

IKNVKCSKTPVIVH---GISRN-----IDLGYQMFA-LNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAYDPTAVPDDITKIMNYLTEAF
|..||.||||||||   ||||.     |.||||..| .........|||.||.... ......|..|...||...|.|..|..| .....|.... .|..
iqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaeekety

TTWFKI
......
kkikql

0040438 (Phosphotyrosine protein) phosphatases II 465-735 4.1e-43 143.3 In-house 34-307 (317) alignment
Range on Protein: 465-735
Range on HMM: 34-307/317.0
SVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEedaNW
.  .. ... ... .    ..  ..|| |.. |..| ||. .|. ...|| . . |.||.||       .||..||. | ...||.|||| .  |   ..
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPl......pntvedFwrmvweqgvtvivmLtelee...lg

NRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS----KTPVIVH---GISR
......|.|.  .. ...|.|.. ....||..... ||| |.. ......||||. |..|   .||.. ..||.... |. .    ..||.||   |..|
rekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgR

N-----IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAYDPTAVPDDITKIMNYLTEAFTTWFKID
      ..| ....  ... .. ...| ||... | |  |  | | .. ...|    .  . ... ..|....|.. . ...|..
tGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvklk

0036941 (Phosphotyrosine protein) phosphatases II 469-704 1.5e-40 134.7 In-house 34-277 (297) alignment
Range on Protein: 469-704
Range on HMM: 34-277/297.0
TDYVKKHSLEQREELPLVMATRVPLnvhgSRLTSDFFHANRIKCPN-GLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMF
. ...  .. .    .    ||| |    .   ||...|. ..... . . |.|| ||.      .|| .||. | ...||.|||| .. |   ..  ..
allpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlp......ntvedFWrmvweqnvtvIvmltelve...lgrekc

CKYFPESADGIVKIGGFKISCCDMEE--DEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISR
..|.|.  .. .. |.|.. . ..|.  ..|.  ||| |.. ......||||. |..|   .|||. ..||..|. |.       |..||.||   |..|
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

N-----IDLGYQMFA---LNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
      .|| .|..     ... ......|.||... | | ..  | | .. .... 
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

0045450 (Phosphotyrosine protein) phosphatases II 438-703 2.5e-37 124.7 In-house 20-303 (307) alignment
Range on Protein: 438-703
Range on HMM: 20-303/307.0
KLTSKSPTEVLKEYVtKLLAKDSEKIKSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSR-LTSDFFHANRIKCP---------NGLQLILTQSPLHK
.|. ...| .|||.  |||    . . .  .. ... ... .  . ..   ||| |.. ...  .||...|. ...|         .... |.||.||..
lllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

ildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanWNRMFCKYFPESaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY--EKEKEFTVTHHLYKSWSMC
      || .||. .....||.|||| .  |    .... ..|.|.. .. . .| |.. . ..|.....  ||| |..  ......||||. |..|   
......tvedFwrmlweqgvtvivmltelvel...grekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdh

SVPENSKTLLKLIKNVKC------SKTPVIVH---GISR-----NIDLGYQMFALNKK---TTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
.||.. ..||..|. |.       ...||.||   |..|      ..| ....  ...    .. ...| ||... | |  |  | | .. ....
gvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0051299 (Phosphotyrosine protein) phosphatases II 477-704 2e-36 121.3 In-house 52-286 (288) alignment
Range on Protein: 477-704
Range on HMM: 52-286/288.0
LEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKC-PNGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPEsa
  .   ..    .|| |.| ..  .||. .|. |.. ... . |.|| ||.      .|| .||. | ...|..|||| .. |   . .. ...|.|.  
knRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp......ntvedFWrmvweqnvrvIvmltklve...lgrekcaqYwpl..

DGIVKIGGFKISCCDMEEDEDVEERTLVVQY-----EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS----KTPVIVH---GISR-----NID
.| ...| ... . ..|...|.  ||| |..      .....||||. |..|   .||.. . ||.... |. .    . ||.||   |..|      .|
ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfiald

LGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
| ....  ... .. ...| ||..  | |  |  | | .. ...|.
llleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

0050432 (Phosphotyrosine protein) phosphatases II 474-704 2.4e-36 121.1 In-house 68-299 (308) alignment
Range on Protein: 474-704
Range on HMM: 68-299/308.0
KHSLEQREELPLVMATRVPLnvhgsRLTSDFFHANRIKCP---NGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKY
 ... .    .    .|| |       .||. .|. ....   .  . |.||.||       .|| .||. | ...|..|||| .  |   |    ...|
nkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPl......pntvedFwrmvweqnvrvIvmLtklve...ngrekcaqY

FPESAD-GIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS--KTPVIVH---GISR-----NID
.|.. . |....|.|.. . ..|...|.  ||| ... ......||||  |..|   .||.. . ||.... |. |  . |..||   |..|      .|
wplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfiald

LGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
| ....  ... .. ...| ||..  | |  |  | | .. ...|.
llleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleyl

0046845 (Phosphotyrosine protein) phosphatases II 479-704 5.1e-36 119.9 In-house 33-274 (284) alignment
Range on Protein: 479-704
Range on HMM: 33-274/284.0
QREELPLVMATRVPLNVHGSR-LTSDFFHANRIKCP------NGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYF
.   ..    .|| |.. ...  .||...|. ....      .  . |.|| || .      || .||. | ...|..|||| .  |   | . ....|.
RykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpn......tvedFwrmvweqnvrvIVmltelve...ngrekcaqYw

PESaDGIVKIGGFKISCCDMEEDEDVEERTLVVQYE--KEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS------KTPVIVH---GISR-----
|.. .. ...|.|.. . ..|...|.  ||| ....  .....||||. |.||   .||.... ||.... |. .      . |..||   |..|     
ple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfi

NIDLGYQMFALNK---KTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
 .|| ....  ..   . .. ...| ||..  | | ..  | | .. ...|.
aldllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

0047943 (Phosphotyrosine protein) phosphatases II 473-703 2.6e-35 117.6 In-house 37-271 (273) alignment
Range on Protein: 473-703
Range on HMM: 37-271/273.0
KKHSLEQREELPLVMATRVPLnvhgSRLTSDFFHANRIKCPN-GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYF
. ... .   .. .  .|| |    .  .||. .|. ....| . . |.|| ||       .|| .||. | ...|..|||| .. |   .... ...|.
enkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPl......pntvedfwrmvweqnvrviVmLtelve...lgrekcaqYw

PESADG-IVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISRN----
|.. ..  .. | |.. . ..|...|.  ||| ... . ....||||..|..|   .||.. . ||..|. |.       |..||.||   |..|     
pleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfi

-IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
 .|| ....  ... .. ...| |||.  | |. |  | | .. ...|
aldllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0043336 (Phosphotyrosine protein) phosphatases II 477-703 2.5e-34 114.4 In-house 48-276 (278) alignment
Range on Protein: 477-703
Range on HMM: 48-276/278.0
LEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPesa
. .    ..   .|| |.. |..| ||. .|. ....| . . |.|| ||..      || .||. |....||.|||| .  |   ...  ...|.|   
knrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe......tvedFwrmvwelgvttivmLtelve...lgrvkcaqYwp...

DGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC----SKTPVIVH---GISRN-----IDLGYQ
.| ...|.|.. . ..|...|.  ||| | .  . ...||||. |..|   .|||. ..||...| |.     |..||.||   |..|      ..| ..
ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllle

MFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
..  ... .. ...| ||... | |. |  | | .. ...|
qlekeggvdleeavkelreqRpgavqtpsqyrflyealley

0039614 (Phosphotyrosine protein) phosphatases II 482-703 2.9e-34 114.3 In-house 64-288 (297) alignment
Range on Protein: 482-703
Range on HMM: 64-288/297.0
ELPLVMATRVPLNVHGSR-LTSDFFHANRIKCPN--GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNrMFCKYFPESADgi
. .    .|| |.. ... | ||. .|. .....  . . |.|| ||..      || .||. |....||.|||| . .|   ... ....|.||. .  
dilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpe......tvedFwrmvweqgvtvivmLtklve...lgr.kcaqywpeegg..

vKIGGFKISCCDMEEDEDVEERTLVVQYeKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISRN-----IDLGYQMF
 . |.|.. . . |.....  ||| |.. .....||||..| .|   .||.....||.... |.       ...||.||   |..|      ..| ....
.tygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleql

ALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
  ... .. ...| ||... | |. |  | | .. ....
ekeggvdvleavkelreqRpgavqtpsqyrflydallel

DSPc_SM00195 449-702 4.1e-34 113.5 In-house 3-260 (263) alignment
Range on Protein: 449-702
Range on HMM: 3-260/263.0
KEYVTKLLAKDSEKikSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLhkildkASTVFKFWWAVRQERV
||...||....|.|  ..  ..  |..|  . .. .... ||| |.   .. .||. .|| ||.. .  . |.|| ||       ||| .||. | .|.|
keefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......pstvedFWrmvweekv

THIVMLGQVNEEdanWNRMFCKYFPESADGIVKIGGFKISCCDMEEDE-DVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
. |||| . .|.    ..   .|.||...|  ..| ... . . |... ... ||| ...|. |....||.. ||.|   .||.. | .|.|.. || ||
kiivmlteeeen...gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

T----PVIVH---GISRN-----IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFM
     |..||   |..|      ||. .. .. .||  . ...|.||..  | | .  .| |..  |  
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

PTPc_SM00194 449-702 4.1e-34 113.5 In-house 3-260 (263) alignment
Range on Protein: 449-702
Range on HMM: 3-260/263.0
KEYVTKLLAKDSEKikSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLhkildkASTVFKFWWAVRQERV
||...||....|.|  ..  ..  |..|  . .. .... ||| |.   .. .||. .|| ||.. .  . |.|| ||       ||| .||. | .|.|
keefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPl......pstvedFWrmvweekv

THIVMLGQVNEEdanWNRMFCKYFPESADGIVKIGGFKISCCDMEEDE-DVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
. |||| . .|.    ..   .|.||...|  ..| ... . . |... ... ||| ...|. |....||.. ||.|   .||.. | .|.|.. || ||
kiivmlteeeen...gkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksk

T----PVIVH---GISRN-----IDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFM
     |..||   |..|      ||. .. .. .||  . ...|.||..  | | .  .| |..  |  
stssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaile

0042113 (Phosphotyrosine protein) phosphatases II 474-702 3.7e-32 107.1 In-house 9-241 (245) alignment
Range on Protein: 474-702
Range on HMM: 9-241/245.0
KHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFP
 ... . .. ..   ||| |...|..| ||. .|. .....   ..|.|| ||..      || .||. ......|.|||| .  |   ..   ...|.|
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe......tvedfwrmlwelgittivmLteeee...lgrvkcaqywp

EsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC-----SKTPVIVH---GISR-----NID
.  ......|.|.. . ..| ..|.  ||| |..  . ....|.|..| .|   .||.....||.... |.      |..||.||   |..|      ..
l..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

LGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFM
| ....  ... .. ...| |||.. | |. |  | | .. ...
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0040439 (Phosphotyrosine protein) phosphatases II 474-703 8.4e-31 102.9 In-house 11-245 (249) alignment
Range on Protein: 474-703
Range on HMM: 11-245/249.0
KHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanWNRMFCKYFP
 ... .    .    .|| |.. ...  ||. .|. |.... . ..|.|| ||..      || .||. ......|.|||| .  |    ..  ...|.|
nkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe......tvedfwrmlwelgitvivmLtslvel...grekcaqywp

EsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC------SKTPVIVH---GISR-----NI
.  .| ...|.|.. . ..|. .|.  ||| ... .. ...||.|  | .|   .||.. ..||..|. |.       ...||.||   |..|      .
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMY
.| ....  ... .. ...| |||.. | |. |  | | .. ....
ylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

Y_phosphatase Protein-tyrosine phosphatase 484-697 1.6e-30 101.6 Pfam-A 11-230 (235) alignment
Range on Protein: 484-697
Range on HMM: 11-230/235.0
PLVMATRVPLnvHGSRLTSDFFHANRIK-CPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESADGIVKIG
.    ||| |  .||  .||. .|| .|  ..  ..|.|| ||       ||. .||. | ||.|. |||| ...|..    . . .|.||. .. .. |
lpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPl......kstiedFWrmvwqekvkvivmltsleekgr...ekcaqYwpeeeeesltyg

GFKISCC-DME-EDEDVEERTLVVQYEKEKE--FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVH---GISRN-----IDLGYQMFAL
 .|. .  . . .....  |.| .. .||..  ..|... |..|   .|||..| ||.||..|. ||    .||.||   |..|      .|.  ...  
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

NKKTTFVSVLKSLRSHCEGPVMQPIEYGFAI
....  ....|.||..  | | .  .| | .
eeevdvlqivkelRkqRpgmvqsleqYifly

Y_phosphatase Protein-tyrosine phosphatase 484-697 1.6e-30 101.6 In-house 11-230 (235) alignment
Range on Protein: 484-697
Range on HMM: 11-230/235.0
PLVMATRVPLnvHGSRLTSDFFHANRIK-CPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESADGIVKIG
.    ||| |  .||  .||. .|| .|  ..  ..|.|| ||       ||. .||. | ||.|. |||| ...|..    . . .|.||. .. .. |
lpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPl......kstiedFWrmvwqekvkvivmltsleekgr...ekcaqYwpeeeeesltyg

GFKISCC-DME-EDEDVEERTLVVQYEKEKE--FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVH---GISRN-----IDLGYQMFAL
 .|. .  . . .....  |.| .. .||..  ..|... |..|   .|||..| ||.||..|. ||    .||.||   |..|      .|.  ...  
dikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

NKKTTFVSVLKSLRSHCEGPVMQPIEYGFAI
....  ....|.||..  | | .  .| | .
eeevdvlqivkelRkqRpgmvqsleqYifly

0045098 (Phosphotyrosine protein) phosphatases II 488-655 2.4e-25 84.9 In-house 47-219 (278) alignment
Range on Protein: 488-655
Range on HMM: 47-219/278.0
ATRVPlnvhgsrltsDFFHANRIKCPnGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsaDGIVKIGGFKIS
 .||           |. .|. |... . . |.|| ||       ||| .||  ......|.|||| .. | . .    ...|.||  .| . .|.|.. 
hsrVk..........dYINAsyidgy.pkkfIatqgPlp......stvadfwrmlwelgitvivmltelvelgre...kcaqywpe..ggsltygdftvt

CCDMEEDEDVEERTLVVQY-----EKEKEFTVTHHLYKSWSMCSVPENS--KTLLKLIKNVKC-----------------SKTPVIVH---GISR
. ..|. .|.  ||| |..     |  ....|||. |..|   .||...  | .|.|.. ..                  |..||.||   |..|
llseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

0037934 (Phosphotyrosine protein) phosphatases II 489-655 4.8e-22 74.1 In-house 25-191 (243) alignment
Range on Protein: 489-655
Range on HMM: 25-191/243.0
TRVPLnvHGsrltSDFFHANRIKCPNglQLILTQSPLHKildkasTVFK----FWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPesaDGIvKIGGF
.|| |   |    ||...|| |....  .||.|| || .      ||.     ||  . ....|.|||| .  |   ..    ..|.|   ...  .|.|
srvkl..eg....sdyinanliyvtp..rliatqgPlpe......tveddlasfwrmlwelgitvivmltelvE...lgrekcaqywp...gev.tygdf

KISCCDMEEDEDVEERTLVVQY--EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVK------------CSKTPVIVH---GISR
.. . ..|. .|.  |||....  ... ...|.|..| .|   .||.. . ||.... |.             |. ||.||   |..|
tvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 469-655 3.7e-21 70.2 In-house 46-227 (301) alignment
Range on Protein: 469-655
Range on HMM: 46-227/301.0
TDYVKKHSlEQREELPLVMATRVPLNVHGSRLTsdfFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedaNWNRMF
  |..|.  ......|    | | . |.| |.     ||| |. . .  ..| ||.||.      .|   ||  . |  | .||||||  |   ..... 
yaylpkdk.hryptvPckPstavevivdGkrvP...ihanwiptsGhphrfiatqgPlk......ntsedfwamlvqydvekivmlgqkve...kleekc

CKYFPESADGIVKIGGFKISCCDMEE--DEDVEERTLVVQYEKE--KEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVH---GISR
 .|.| .    ..|| |||   ..|   .... .||| |.   .  .  ||||. |..|.   ||.    | .|.. || |. |..||   || |
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 438-680 7.4e-21 69.0 In-house 20-259 (290) alignment
Range on Protein: 438-680
Range on HMM: 20-259/290.0
KLTSKSPTEVLKEYVTKLLAKDSEKIKSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGsrlTSDFFHANRIKCPNGlQLILTQSPLhkildkASTVFK
. ..|.. |. |||..||      .     . |   .   ..  ...    ||| |.  .     |. ||| .|  .   .|||| .|      ..||. 
dvvkknvdelakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkdGy...dGdyvhanyvkGlka.mfiltqGal......kdtvid

FWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADGIVKIGGFKISCCDM-EEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLL
.|  | ||.|. |||| .. |.    .    .|.|| .  .. .| . . |.   ..|...  .|| |.  .. ||  . |.  |||   ||.  . .||
iwrmvlqekvaaivmlceliedG...kakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlall

KLIKNVKCSKTPVIVH---GISR-----NIDLGYQMFALNKKTTFVSVLKSLR
.... ..    ||.||   || |      |. | |..   |.   . . ..||
rtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralr

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 532-708 1.1e-20 68.9 In-house 38-225 (255) alignment
Range on Protein: 532-708
Range on HMM: 38-225/255.0
ASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYE-KEKEFTVTHHLYKSWSMCSVPEN
. || ||. .. | . . .|||.  .||. .      .|||   |.  |.   .... .   |  .  .... ..  | |  ||.|. || |     ||.
sltvdkfyqtivqtktevvvmlcdfaeegve...kcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

SKTLLKLIKNVKCSKtPVIVH---GISRN-----IDLGYQ--MFALNKKTT----FVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAY
.. .|...| |. || .|.||   || |      ..| ||  . .|..  |    ..|.|. |||. .. . .|..  |.|. .. . | . 
areilnilkvvrdsk.svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkg

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 481-653 5.7e-20 66.1 In-house 44-208 (281) alignment
Range on Protein: 481-653
Range on HMM: 44-208/281.0
EELPLVMATRVPLNV-HGSRLTSDFFHANRIKCPNG-LQLILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRM-FCKYFPESADG
 ..| .  .|| |.|    . ..|. ||| |. |      |||| |      |  |   ||  . ||  | |||| |. |     ||   ..|||  |  
lnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgp......kketradfwrmiwqenttaivmlcqflet....nrekcaeyfprnahc

IVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKEFtVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHGI
 ...  . .|  |   .. .    | . || |  . .|| |.| |    ||| |. .||.......  || ..|  
clqfdklsvsyedstvnkslvttrlnlsyegetrl.ithwlwkewpdwqvpessevmlkilrkirarstppvihcs

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 483-651 5.7e-20 65.9 In-house 53-215 (515) alignment
Range on Protein: 483-651
Range on HMM: 53-215/515.0
LPLvMATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKI
||.   .|| |.|      ||.| |  |.  .     | .| |..      ..|  ||  | ||.|| |.|. . .|.|        ||.|.     || 
lPy.dsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnk......asvddfWrlvlqenvttiamvtklkegdki...kcgkyWPdkpgdsvkf

GGFKISCCDMEEDEDVEERTLVVQYEKEkEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT----PVIVH
| .|..   .| . .   |.| |  ...   ||| . .. |    ||.....||||||.||...     |.|.|
Gsikvelvsleactggikrkltvlkgdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliih

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 480-651 1.1e-19 65.5 In-house 51-216 (315) alignment
Range on Protein: 480-651
Range on HMM: 51-216/315.0
REELPLVmATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRM-FCKYFPESADG
.. |||   .|| |.|      ||.. |  ||  .     | .| ||.      ..|  ||  | ||.|| |||. . .|.|    ..   .|.|.    
knilPld.sarvkleviddsPdsdyinasyiksvdddkayiasqgPlk......asvddfwrmvlqekvttivmvtkkqegd....kikcrqywPdrkad

IVKIGGFKISCCDMEEDEDVEERTLvVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT----PVIVH
 |. | .|..  ..| | |   | | |  . |.  ||| . .. |    |.... .||||||.||...     ...||
svefGsikvellsleadtdgvarkl.vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvh

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 488-646 9.1e-19 62.6 In-house 42-195 (274) alignment
Range on Protein: 488-646
Range on HMM: 42-195/274.0
ATRVPLNVHGSRLT-SDFFHANRIKCPNGLQ--LILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRM-FCKYFPESADG--IVKI
 .|| |. . |.   |..  || || ... .   . || ||      ..||. ||  . ||.|. |||| ...|.    |.    .|||.. |     . 
nsrvllesessededssyinanyikGydeeskayvatqGPl......pntvadfWrmiyqeevqvivmltklkea....neqkCavyfPdaedyeisery

GGFKISCCDMEEDEDVEERTLVVQYEKEkEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT
|...|   .. | .| . |.||..| .. | .|.|..| .|    .|.. .|||.|...|. |..
gdveikvekiverndysvrklvlkyler.ersvkhywytdWPdhksPddantlldlvleveesre

subfamily_hpo-7_pd Subfamily hpo-7 533-708 1.3e-18 61.9 In-house 45-231 (263) alignment
Range on Protein: 533-708
Range on HMM: 45-231/263.0
STVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYE-KEKEFTVTHHLYKSWSMCSVPENS
 |. ||. ...| . . .|||.  |||. .      .|||   |.  |.   .... .. .|  .  . |. . . | |  ||.|. || |     ||..
qtidkfyqtivqtktevvvmLcDfneegve...kcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

KTLLKLIKNVKCSKTpVIVH---GISRN-----IDLGYQ--MFALNKKTT----FVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYAFEAY
.  |...| .. ||  ..||   || |      ..| ||  . .|..  |    ..|.|. |||. .. . .|.   |.|. .. . ....
reilnilkvarnsks.lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 454-653 2.8e-18 61.1 In-house 29-227 (305) alignment
Range on Protein: 454-653
Range on HMM: 29-227/305.0
KLLAKDsEKIKSVGMTDYvKKHSlEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVM
|.|... |.   || ..  .|.. .. .|  |    |. |. . |   ||.  |. ..  ..  . |..|.||.      .||  ||  . .|.|..|||
kslyee.eesidvgkkea.nkak.nrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlk......ntvadfWrliveekvstivm

LGQVNEEDANWNRMfckYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQY--EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC----SK-
| .. |.. .  |.   |.|||    ...| |..   . .. .|  || | .    |.... ||...   .|    ||. . .||.|||.|.     .| 
ltklveggkdkCrq...YWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkg

TPVIVH---GI
.|..||   |.
vpllVhCsagv

subfamily_PTPN3_pd Subfamily PTPN3 503-652 5e-18 60.0 In-house 66-215 (280) alignment
Range on Protein: 503-652
Range on HMM: 66-215/280.0
DFFHANRIKC--PN---GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADgIVKIGGFKISCCDMEEDEDV
|.  || ..   |      . | || ||      |.|. .||  | ..... |||| .. |.        ..|.||. |  .. |.|.. |   .|.. .
dyinanyvnmeipstglvnryiatqGPl......aktatdfWqmvweqksslivmlttlverG...rvkChqyWPeted.eleygefsvkcekedetksy

EERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVHG
  | ||.. .. ..| ....  | .|.  .||..|. .|.....|.  .    .||.|| 
vlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

subfamily_PTPRB_pd Subfamily PTPRB 477-651 7.8e-18 59.5 In-house 54-224 (293) alignment
Range on Protein: 477-651
Range on HMM: 54-224/293.0
LEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPES
 .. ...    ..|| |.   .. .||.  || |.  |   . | || ||..      || .||  | ..... |||| |. |.     .. | .|.|. 
knrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe......tvddfWrmvwekkssiivmltqlvekg....kvkCeeYWPad

ADGIvKIGGFKISCCDMEEDEDVEERTLVVQYeKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVK------CSKTPVIVH
 . .   |  |..    || ||   |.| ..  ...| .|... ..||.   |||..||||.....|.      .||.|..||
eepv.lyGdikvtlvaeeeledwvirelkiek.ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 433-651 1.4e-17 58.7 In-house 9-218 (288) alignment
Range on Protein: 433-651
Range on HMM: 9-218/288.0
FEKDEKLTSKSPTEVLKEYVTkLLAKDSEKIKSVGMTDyVKKHSLEQREELPLVmATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLhkildk
 .|  |   .. |.. .|| . | | ...| ...|    | ..    |. ||.   .|| |.      ..|.  |. |.  ..  . | ||.||      
vakvakksarnrtgfseeyns.Laalektksvtagrla.vnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPl......

ASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsADGIVKIGGFKISCCDMEEDEDVEERTLVVQyEKEKEFTVTHHLYKSWSMCSVPENS
|.|| .||  | ..... |||| .. |.. .      .|.|. ||  .. | ...   . .| ||. .|.| ..  |..|...|.. |..|.  .|||..
adtvndfWelvyenktstivmltelveggkt...kCeeYWPd.adkpknyGsvtvtlveskeledfvlrkllle.kkkteleitqyqylaWpdhgvPesk

KTLLKLIKNVKCSKT----PVIVH
. ||.|...|| ...    |.|||
apllellrqvkvanqadtgpiivh

subfamily_Ptp69D_pd Subfamily Ptp69D 482-652 1.4e-17 58.8 In-house 56-226 (307) alignment
Range on Protein: 482-652
Range on HMM: 56-226/307.0
ELPLVMATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEedanWNR-MFCKYFPESadGIV
..     ||| |..   . .||.  |. ||   .  . |  | |.       .|.. ||  . .  || |||| ...|    .||    ||.|.    .|
dikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve......atigDfWRmiaeqevtlivmlsnlte....knrkkcakYWpie..dev

KIGGFKISCCDMEEDEDVEERTLVVQYEK------EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNV----KCSKTPVIVHG
. |   . . . |. .|  .|.| |   |      |..  |. . |..|    ||| ...|||||..|    | ...|..|| 
qygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhC

subfamily_PTPN23_pd Subfamily PTPN23 489-651 3.3e-17 57.2 In-house 58-218 (288) alignment
Range on Protein: 489-651
Range on HMM: 58-218/288.0
TRVPLNvhgsRLTSDFFHANRIK--CPNGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANWNRmfcKYFPESADGIVKIGGFKI
.|| |.      . |.  |  .|   |   ..| ||.||.      ||.  ||  | ....  |||| . .| . . .    .|.||. .  || | ...
nRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlq......stlnDFWlmvyeqkssviVmllskeelgkpkvd...rYwPedkgetvkfgdlsv

SCCDMEEDEDVEERTLVVQYEKEKE-FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC--------SKTPVIVH
.. . .| | . ||.| .. .....  .|.|  ..||.   ||.  .|||.....|.         ||||..||
tlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvh

subfamily_PTPN12_pd Subfamily PTPN12 488-651 7.3e-17 56.2 In-house 54-213 (290) alignment
Range on Protein: 488-651
Range on HMM: 54-213/290.0
ATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPESADGIVKIGGFK
 .|| |. . .   ||.  || || ..| |. | .|.||      . |.  ||  . . .|. .||. .. | .    .. | .|.||. .  ...| |.
ksrvelskieeeegsdYinanfikgvegkleyiaaqgPL......pktlddfWrmiweknveivvmaCrevelg....kkkCerYWpeegeeelefgefe

ISCCDMEE-DEDVEERTLVVQYEKEKEfTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK----TPVIVH
... . .  |.|   ||| |. .||.  .|.   |..|    ||.. |.||.||..|.. .    .|..||
vtleeekavdddflirtLkveaqkesr.kvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvh

subfamily_PTPRK_pd Subfamily PTPRK 496-650 1.6e-16 55.1 In-house 65-215 (314) alignment
Range on Protein: 496-650
Range on HMM: 65-215/314.0
HGSRLTSDFFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVnEEDANWNrmFCKYFPESADGivkIGGFKISCCDMEED
      ||.  |. |    .  . | || ||.      .||  ||  | .|. . |||| ..  | ....   .||.|| ..     | .|. . ..| .
idgdpssdyinaalidsykrpaafivtqgPlq......etvkdfWrlvydencasivmltel.vevgrvk..ClkyWPedtev...ygdikvelvetell

EDVEERTLVVQY---EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTP----VIV
...  |.. |.     .|.  .| .  . .|..  || . ..||||...|| |. .    ..|
aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 489-651 2e-16 54.9 In-house 24-181 (250) alignment
Range on Protein: 489-651
Range on HMM: 24-181/250.0
TRVPLNVHGSRLTSDFFHANRIKCPNGLQ-LILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrmFCKYFPesADGIVKIGGFKIS
.|| |. . .   ||.  |  ..  .. .  | ||.||..      |. .||  | .| .. |||| ...|.. .    . .|.|  ...  | |. ..|
srvvLekekgdkesdyinasflhgyderkafiatqgPlqa......tiedfWrmvleeksgtivmLtnLkesekt....yhqywP..vekaekyGdvtvs

CCDMEEDEDVEERTLVVQYEKEK-EFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC-----SKTPVIVH
  . ||  |.. |.|..  .|.. | .| .  . .|   .|||. .. |.|.|.|.       ..||||.
llskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivq

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 489-651 3.6e-16 54.3 In-house 71-229 (298) alignment
Range on Protein: 489-651
Range on HMM: 71-229/298.0
TRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESadGIVKIGGFKIS
.|| |. . .   ||.  |  ..  .|    |.|| ||..      ||  ||  | .| .. |||| ...| |      . ||.|..  |  . | ...|
sRvvLekedadeesdYiNAsflhaykgrnafiatqaPlte......tvedFWrmvteedigtiVmltnleeldkt...kyhkywPde..gketygeitvs

CCDMEEDEDVEERTLVV-QYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC-----SKTPVIVH
    ||  |.. |.| | ....||| .| .  . ||.  .||||....|.|...|.       ..||||.
llskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivq

subfamily_PTPRD_pd Subfamily PTPRD 489-651 5.6e-16 53.3 In-house 63-220 (564) alignment
Range on Protein: 489-651
Range on HMM: 63-220/564.0
TRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESaDgIVKIGGFKIS
.|| |.       ||.  |. |.  .   . | || ||      |.|.  ||  | ..... |||| ...|.. .    . ||.||. .   ..|.....
sRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPl......aetiedFWRmvweqnsstiVmltkleEkgkv...kchkYWPek.g.tetygeltVt

CCDMEEDEDVEERTLVVQYEKEKE-FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS----KTPVIVH
  . || .|.| ||. .. .|..|  .|..  . ||    |||. ..||.||..|. .    . |..||
leeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVh

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 464-704 8.2e-16 52.8 In-house 10-264 (270) alignment
Range on Protein: 464-704
Range on HMM: 10-264/270.0
KSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLTSDFFHANRIKCPN--GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDA
..  . ...... |   ...    |||| |.   .  .. .. || ..  .    . | ...||      ..|...||  . .|.|| |||. ...|.  
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPl......pttlksfwrmiweekvtaivmttgleEkgr

NwnrmFC-KYFPESADGIVKIGGFKISCCDMEED--EDVEERTLVVQyEKEKEFTVTHHLYKSWSMCSVPENSK------TLLKLIKNVK--CS---K-T
.     | .|.|....  ||.   ||. . ..|   |    . | .. || .|  ..|. |..|   .||...        |||....|.  ..   | .
k....kCerYWpaepkekvkledgkikvlalseekeegyiltrlrle.ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae

PVIVH---GISR-----NIDLGYQMFALNKKTTFVSVLKSLRSHCEGPVMQPIEYGFAIYGIFMYA
|..||   |. |      .| . ..   .||   ..... || .    | .| .| |.  .. .||
PllvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya

subfamily_PTPN9_pd Subfamily PTPN9 484-645 1.1e-15 52.4 In-house 52-206 (297) alignment
Range on Protein: 484-645
Range on HMM: 52-206/297.0
PLVMATRVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPESADGIVKI
  .  ||| |.      .||. .|| .   .    .| || ||.|      ||  ||  | ...|  |||  .| |.     |. | .|.|.. .   . 
lcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkk......tvsdfWrmvWeqevlvivmttrvverg....rlkcgqyWpleeessaef

GGFKISCCDMEEDEDVEERTLVVQY-EKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
| ...|  ..|| || ..|.|...  ..|.. .|||. . ||    ||.....||.....|.  .
gdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 501-655 1.2e-15 51.9 In-house 79-234 (305) alignment
Range on Protein: 501-655
Range on HMM: 79-234/305.0
TSDFFHANRIKCPN--GLQLILTQSPLHKILDkastvfKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADGIVKI-GGF---KIS-CCDMEE
 ||. ||| . ||     ..| .| || . .|      .||| | |..| .|||| .  |     .   ..|.| .    ... .|    ..| .  || 
psdyihanyvgcpmipekrficaqgpldqtid......efwwmviqnkveqivmlcktvelg...klkcaqywpaaqgeklelksgivvenvsgskpmer

DEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHG---ISR
| ...  .| . |  .....| |  .  |    ||    | |.|.  .. || |..||    | |
daeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigr

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 488-651 3.8e-15 50.8 In-house 55-214 (281) alignment
Range on Protein: 488-651
Range on HMM: 55-214/281.0
ATRVPLNVHGSRLTSDFFHANRIKC-PNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRMFC-KYFPESADgIVKIGGFK
|||| .. . .  ..|.  || ..   .  . | ||.|.       ... .||. | ...|. |||. .  |.    ... | .|.|. .   .|.| ..
atrvkvtpneenkntDYinanfvpgykgekeyiatqgPv......PaslvafWqmvweqkvsaivmvtreiea....gklkChrYWPddns.elkygdvt

ISCCDMEEDEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNV-KCS----KTPVIVH
..    || .   ||.. .. |. .. .|..  |..|    ||...| ||.  |.| |..    |.|...|
vkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvih

subfamily_PTPN6_pd Subfamily PTPN6 480-644 1.9e-14 48.4 In-house 61-218 (306) alignment
Range on Protein: 480-644
Range on HMM: 61-218/306.0
REELPLvMATRVPLNvHGSRLTSDFFHANRIK--CPN-GLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESAD
.  ||    ||| |. . |   ||.  || ||   ..   . | ||  |       .||  ||  | ||  . |||. . .|   .   . ..|.|.. .
knilPf.Dhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgcl......ettvsdFWrmvwqensrvivmttkevErgke...kCarYWPdeee

GIVkIGGFKISCCDMEEDEDVEERTLVVQ--YEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS
     |  ...... .. .| . |.|.|.   .|..| .| .. .|||   .||.. ...|.....|.  
kee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrk

subfamily_egg_pd Subfamily egg 484-653 3.1e-14 47.4 In-house 50-209 (307) alignment
Range on Protein: 484-653
Range on HMM: 50-209/307.0
PLVMATRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanwnrMFCK-YFPESADGIVKI
.    .|| |...  . . || ||||.|      ..||.|.||        ||  ||  | ||.| .||||    |         |. |.| . .  ...
hckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkn......tvddfwrmvfqeevqyivmltsrkes......erceyywpkaesdslvt

--GGFKISCCDMEEDEDVEER--TLVVQYEKEKEFTVtHHLYKSWSMCSvpeNSKTLLKLIKNVKCSKTPVIVHGI
  |...| . ....  |   |   | .   ...|  .  |    .   |   .  . |.... ..   .||.|. |
vpGslrienlkvdskadplfrvtklklvGgddeerfl.ehwqgdvnnss...dvysplrvlrklrnlskpvvvqdi

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 440-652 3.8e-14 47.1 In-house 17-226 (305) alignment
Range on Protein: 440-652
Range on HMM: 17-226/305.0
TSKSPTEVLKEYVTKLLAKDSEKIKSVGMTdyvKKHSLEQREELPLVMATRVPLnvHGsRLTSDFFHANRIKCP-NGLQLILTQSPLHKildkasTVFKF
  |.|. . .|.|.    .| ||.|.   .   ...  ..  ..  .   || |  .|     .. ||| .  | |  ..| ||.||.|      |   |
lekgpaglraefvamkrfndfekmkafkea...qeagknrykdvgcldnnrvkl..eg.pwpheyihanyvstptnpkrfictqaplek......tcadf

WWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESADGIVK--IGGFKIS---------CCDMEEDEDVEERTLVVQYEKEKEFTVTHHLYKSWSMCSV
|.   |..|  | || .. |  |   .  ..||.   . ...   .| |||             . . .|.|  ||..   ||   |||. .  |    |
wymclqdkveaifmlcnllekga...kkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgv

PENSKTLLKLIKNVKCSKTPVIVHG
|    ..|.|... . || |..|| 
paadlailellekarpskgpivvhc

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 445-694 4.2e-14 47.1 In-house 19-273 (290) alignment
Range on Protein: 445-694
Range on HMM: 19-273/290.0
TEVLKEYVTKLLAKDSEKIKSVGMTDyvkKHSLEQREELPLVM-ATRVPLNVHGSR--LTSDFFHANRIK-CPNGLQLILTQSPLHKildkasTVFKFWW
.|  ..  ..| . .||.   ||.|    . .| .| .  .|    |..|.  ...   | .. .|  ||   .  | |.||.|...      |. .|| 
negfrnqfkmldsgesehtvtvglts...snkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn......tlvdFWk

AVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESaDGIVkIGGFKISCCDMEEDEDVEERTLVVQYEKE--KEFTVTHHLYKSWSMCSVPENSKTLLKLI
 . ||.|| |||| ...||.        .|.|.| |    .| |.|   . |. ..  ||.| |. ...  .. .||..  ..|      .| .| | .|
liwqekvtiivmltniieegk...vkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvi

KN-----VKCSKTPVIVH---GISRNIDLGYQMFALNK-----KTTFVSVLKSLRSHCEGPVMQPIEYG
..      |  .|...||   ...|   .   . ..||         ..||||.|.   | |    .| 
eemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 487-651 4.3e-14 47.3 In-house 64-223 (297) alignment
Range on Protein: 487-651
Range on HMM: 64-223/297.0
MATRVPLNVHGSRLTSDFFHANRIKCPNGlQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnrMFCKYFPESadGIVKIGGFKI
   || |.. ..   ||.. |  .|  .  .|| || | .      .||  ||  | .|.|. |||| . ||.|        .|....  |... |   .
dssRvkLaivnddpdsDyvnasfvkgnkh.rlittqmPmk......atvadfWamvldeqvstivmlnddnerdk....kcaryWsdk..gvttfGdvsv

SCCDMEEDEDVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPE--NSKTLLKLIKNVKCS-----KTPVIVH
    ..| |   .|.|.|. .|  ..  |  . . .|   .|..  . ..|||||..|. .     ..|..||
vllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 478-651 8.4e-14 46.3 In-house 49-222 (319) alignment
Range on Protein: 478-651
Range on HMM: 49-222/319.0
EQREELPLVMA---TRVPLNVHGSRLTSDFFHANRIKCPNG-LQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRMFCKYFPE
...   . ..|   ||| |        ||.  |. |   .   . | ||.||..      |.  ||  | .|..  .||| ...|.     ....| ...
kkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen......tiedfWrmvWeeessivvmltklvek....lkvklkkywp

SADgIVKIGGFKISCCDMEEDEDVEERTLVVQYeKEKEF---TVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK-----TPVIVH
... ... | . .   . || ||.. | | ..  |  |    .|.|. |..|.   |||....||.|.|... |.      |..||
een.feeyGrlivtleeeeeledyiirklklnk.kssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvh

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 515-652 9.9e-14 46.0 In-house 85-218 (287) alignment
Range on Protein: 515-652
Range on HMM: 85-218/287.0
GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADgiVKIGGFKISCCDMEEDEDVEERTLVVQYEK--EKEF
  . |...||. .      |. .||  . ...|| |||| | .|.| .   .  .|.||..   | .| ..|.  . |  ... ||.| |. ..  ... 
kkafiiaesPmfn......tarnfWkliddrnvtaivmlcqekendee...vcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkq

TVTHHLYKSWSMCS-VPENSKTLLKLIKN----VKCSKTPVIVHG
.|. . . .|     |.|    || . .      | ..|...|| 
qvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

subfamily_PTPN13_pd Subfamily PTPN13 479-654 3.3e-13 44.6 In-house 43-214 (273) alignment
Range on Protein: 479-654
Range on HMM: 43-214/273.0
QREELPlVMATRVPLNVHGSrltsdFFHANRIKCP---NGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwnRMFC-KYFPES
 |. || . .|||.|. .|.     .  |. || |   .  . |..| || .      ||  ||  | . ... |.|. .  |..    .. | .|.|||
yrnvlP.ydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPe......tvkdfwqmvweqkaeviamvtlekekg....kvkchrywPes

ADGIVKIGG-FKISCCDMEEDEDVEERTLVVQYEKE-KEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK---TPVIVH---GIS
..  .|. . ....  .... ..   |.| |.  .  .   |.|  . .|   .|| ... ||.....|.  .   .|..||   || 
knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiG

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 467-660 9.4e-13 42.8 In-house 36-222 (288) alignment
Range on Protein: 467-660
Range on HMM: 36-222/288.0
GMTDYVKKHSLEQREELPLVMATRVPLNvhgsrLTSDFFHANRIKC--PNGLQLILTQSPLhKildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDANWN
 .. .... . .. |.||   .||| |.       .||. | ..    ..  .|| .|.|| .     .|. ..|  . .. | .|||| .. |   .  
iidsfianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPl.n.....gtieelWkmllesdveyivmlcellekGkeks

rmfCKYFPESADGIVKIGGFkisCCDMEEDEDVEERTLVV---QYEKEKEFT--VTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVH---GISRN
    .|||      ..|| .   | .. .. .  .....|   . .|| | .  | .  .. |   .|||| .. |.|.. .|  . |..||   |. | 
...aeyfPsklGekarigrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrt

IDLG
  | 
gtli

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 512-652 5.2e-12 40.2 In-house 71-206 (283) alignment
Range on Protein: 512-652
Range on HMM: 71-206/283.0
CPNGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQYE--KE
  .. . | .||||..      ||  ||  | .|..| |||| .. |.    .   ..|.|.  .| .. | | ..  .    .    . |.....   .
ykqdkkyiiaqsPldr......tvvdfWkmvfdekitaivmltklqedl...rikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssak

KEFTVTHHLYKSWSMCSVPENSKTL--LKLIKN--VKCSKTPVIVHG
... ..|. .  |  ..      .|  . ...    .  |.|..|| 
stlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhC

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 464-651 1.2e-11 39.3 In-house 37-219 (318) alignment
Range on Protein: 464-651
Range on HMM: 37-219/318.0
KSVGMTDYVKKHSLEQREELPLvMATRVPLNVHGSRLTSDFFHANRIKCPNGL-QLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDan
 |.  .. | |.       |.    ||| |.   .  .||.  || |   .   . | .|.||      . |.  ||  | .   . |||| |..|.   
tslkslepvnkaknryanilay.dhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPl......petieDfWrmvWeqnsavivmltqeeerg..

wNRMFCKYFPESadGIVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKE-FTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK-----TPVIVH
  .   .|.|..  |  ..|  ..   .  | .|   |.. |. ..|.|  .|  . | ||.  .|||.. .||.|...|.  .     .|..||
.kakvhryWPsk..gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 480-652 1.4e-11 39.0 In-house 47-216 (307) alignment
Range on Protein: 480-652
Range on HMM: 47-216/307.0
REELPLVMATRVPLNVHGsrLTSDFFHANRIKC-PNGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEdanwNRMFCK-YFPEsADG
 .... .  .|. ....|  |.||. ||| .    .  ..| .| ||.      .|...||  . ||.|  ..|| .| |      .. |. |.|   .|
yqdvkcqdkgrivvkfdg..lasdyihanylgiaikpkkficaqgple......ntqysfwamaiqekvesvimlckviel....akikceqywpl.eeg

IVK---IGGFKI-----SCCDMEEDEDVEER-TLVVQYEkEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHG
  .     .  |      .  .  |||. .  || |..  .|  |..|  .. |    ||.   | . |.. |.  . ||.|| 
qklvfgeapntisvanlgakklapdedlinvttlkvdwa.qksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhc

subfamily_PTPN1_pd Subfamily PTPN1 500-645 1.7e-11 38.4 In-house 54-195 (290) alignment
Range on Protein: 500-645
Range on HMM: 54-195/290.0
LTSDFFHANRIKCPN-GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESAD-GIVKIG--GFKISCCDMEEDE
   |.  |. .. ..   . |||| || .      ||  ||  | ...   .||| .| |.. .      .|.|.  .   ...    .|.     |. .
adndyinaslveleeakrsyiltqGPlpn......tvdhfWqmvWeqkskavvmlnkvvekeqi...kcaqywPqgeeekellledtklkvkliseerks

DVEERTLVVQYEKEK-EFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
    |.| ..  | .   ...|. | .|.  .|||   ..||.. .|. | 
yytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresG

subfamily_PTPRA_pd Subfamily PTPRA 490-645 3.2e-11 37.7 In-house 74-224 (330) alignment
Range on Protein: 490-645
Range on HMM: 74-224/330.0
RVPLNVHGSRLTSDFFHANRIKCPN-GLQLILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsaDGIVKIGGFKISC
|| |.|     .||.  |  |.  .   . | .| |      |. ||  ||  . . . . |||| ...| . .      .|.|.  .|.|  |  ... 
rvilsvkeGveesdyinasfidGykekdkfiaaqGP......keetvedfwrmiweqksativmltelkerkee...kcaqywPd..eGlvtyGnirvev

CDMEEDEDVEERTLVVQ-----YEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
 |... .|.  | ..||      ...|.  |.   ..||    || ... .|||.|.||  .
edetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkkln

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 490-646 7.7e-11 36.5 In-house 65-209 (315) alignment
Range on Protein: 490-646
Range on HMM: 65-209/315.0
RVPLNVHGSRLTSDFFHANRIKCPNGLQ-LILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESadgIVKIGGFKISC
|| | .      ||.  || |.  |  .  | .|.|.      ...|  ||  | .| ...|||| .. |..   .|.  ||.|.     |  | . .. 
rvqlpllendphsdyvnanfidGynkkrryiaaqgpn......vasvkdfwrlvfeedigkivmltnlvege...krkaekywpdk...kviyGkitvtr

CDMEEDEDVEERTLVVQYEKeKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKT
 . |  ...  ||| | ... .  .|    | ||    ||. . .|..||..||  .|
kseevnteytvrtlsvvfgd.nirevvqlhytswpdmgvpkytiplmnlirtvkqhht

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 480-651 2.1e-10 34.6 In-house 52-175 (392) alignment
Range on Protein: 480-651
Range on HMM: 52-175/392.0
REELPLVmATRVPLNVHGSRLTSDFFHANRIKCP-NGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDanwnrmfckyfpesadgi
.. ||.  ..|| |.|      ||.. |  |..  |    | .|.|       |...  ||  | ||.|| |.|. ...| |                  
knilpyd.sarvkleviddipdsdylnasyipsfdnekayiasqgpn......aaslddfwrmvfqenvttiamvtklkegd..................

vkiggfkisccdmeededveertlvvqyEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK---T-PVIVH
                              ..  ||. . .  |    ||. . .|||.||.||.     | |.|.|
............................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliih

subfamily_PTPRG_pd Subfamily PTPRG 489-652 2.1e-10 34.4 In-house 62-227 (563) alignment
Range on Protein: 489-652
Range on HMM: 62-227/563.0
TRVPLN-VHGSRLTSDFFHANRIKCP-NGLQLILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPEsaDGIVKIGGFKI
.|| |. . |   . |.  || |.    . . | || ||.      .|.  ||  . ...|. |||. ...|. .   |    |.|.  |. ...| ...
sRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk......dtfddFWrmiWeqnvaiivmitnlvergr...rkcdvYWPk..desetygalqv

SCCDMEEDEDVEERTLVVQY---EK----EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS-KT---PVIVHG
   . |      .||||..    .|    ..| .|... | .|  ..||| |   |. .|  . . |.   |..|| 
tlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 489-642 2.4e-10 35.0 In-house 18-163 (237) alignment
Range on Protein: 489-642
Range on HMM: 18-163/237.0
TRVPLNVHGSRltSDFFHANRIKCPNGL--QLILTQSPLHKILDkastvfKFWWAVRQERVTHIVMLGQVNEEdanwNRMFC-KYFPeSADGIVKIGGFK
.|| |.  ||   ||.  |. .|  .|   . | .| ||    |       ||  | ||. . ||||  . |     |.. | ||.| |.|     | . 
srvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscd......dfwqmvwqekcsvivmltglieg....nelkchkywp.stdqpaaygvlt

ISCCDMEEDEDVEERTLVVQYEK-EKEFTVTH-HLYKSWSMCSVPENSKTLLKLIKNVK
.| .  ||  |   |.|.....   ||  . | . . ||    ||... .||.. ||. 
vslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrknii

0041856 (Phosphotyrosine protein) phosphatases II 502-652 2.8e-10 35.6 In-house 19-119 (182) alignment
Range on Protein: 502-652
Range on HMM: 19-119/182.0
SDFFHANRIKCPNGL-QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGqvneedanwnrmFCKYFPesadgivkiggfkisccdmeededveer
.|. .|| . ..    . |.|| || .      || .|.  ......|.||.|              . |.|                            
ldyInanlylgslpatrfiatqgplls......tvadflrmlkelgittivnlt............eelywp............................

tlvvqyeKEKEFTVTHHLYKSWSMCSVPEnSKTLLKLIKNVKCSKTPVIVH---G
       .. | .....|| .|   .||.   .||..|. |. .. ||.||   |
.......ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaG

subfamily_PTPRN_pd Subfamily PTPRN 481-653 3.7e-10 34.0 In-house 64-232 (297) alignment
Range on Protein: 481-653
Range on HMM: 64-232/297.0
EELPLvMATRVPLNVHGSRLTSDFFHANRIK--CPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGI
. ||    .|| |. . |. .||.  |  |    |     | ||.||      |||| .||  | .. |. ||.| ...||. .      .|.|.    .
avlpy.dhsrvklkeeasaeksdyinasaildhdprapayiatqgpl......astvadfwqmvweqGvvvivnltrleeegvk...qckrywpdeGsev

VKIGGFKISCCDMEEDeDVEERTLVV-QYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVK----CSKTPVIVHGI
 .|   ..    .  | |   |.. . . ....  |||   . ||   .|| ..|.||.. . |        .|..||. 
yhiyevhlvsehiwcd.dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcs

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 451-655 6.1e-10 33.0 In-house 14-234 (302) alignment
Range on Protein: 451-655
Range on HMM: 14-234/302.0
YVTKLLAKDSEKIKSVGMTDYVKKHSlEQREELPLVMATRVPLNVHgsrLTSDFFHANRIKCpNGLQLILTQSPLH------K-----ILDKASTVFKFW
.  . . .  ||.|    | . |. | |.|..| .     ..  |    . .||  || .|  .... |..| |.       |     |  | ||. |.|
efleyveraleklkkktstnlekdis.errkslficepktmaklvd...fkndfinanvlkl.deikwimaqGpmdGtekkekvskkpivpkkstlekhw

WAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPESADGIVKIGGFKISCCDMEEDED--VEERTLVV--------QYEKEKEFTVTHHLYKSWSMCSVPE
  . | .|. .| | .. |..   .. . .|. .  .| .| | . .   ....| .   . .....        . .|....||   .. .|     |.
alieqynvaivvqlcsfvede...ekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsawpdhGapk

NSKTLLKLIKNVKCSKTPVIVH---GISR
...| |...|  .. |. |.||   |. |
eaytaldilkfcesykknvlvhcsaGvGr

subfamily_PTPN14_pd Subfamily PTPN14 481-643 2.3e-09 31.6 In-house 57-214 (300) alignment
Range on Protein: 481-643
Range on HMM: 57-214/300.0
EELPLvMATRVPLNVHGSRlTSDFFHANRIKCPNG---LQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDanwNRMFCKYFPES--A
. ||    .|| |.      ....  | .|| . |   .. | .|.||..      || .||  | .. |. |||| . .|.    .    ||||..   
dvlPy.ednrvelsptken.stgyinassikvsvggkersyivaqgPlel......tvqdfWqmvWeqgvqlivmlteeeedg...keksfkyfPklesk

DGIVKIGGFKISCCDMEEDEDVEERTLVVQYEK-EKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKC
   |. | ||..    |. . |  ..| ...   ..| || |  |. |.   |||. |. |. ...|. 
kktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqs

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 489-641 4.5e-09 30.5 In-house 53-197 (287) alignment
Range on Protein: 489-641
Range on HMM: 53-197/287.0
TRVpLNVHGSRLTSDFFHANRIKC-PNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEdANwNRmFCKYFPESaDGIVKIGGFKIS
||| | .. ..| ||.  || .    .  . | .|.|.      |.|| .|| || ..|.. .... .  || |  ..   ||.||  .  ...||. . 
trv.llsaegelGsdyinanyvasytddeafiaaqgPi......aatvrdfwravletrsasvitmtrevee.ar.lk.cykywPer.evPmrvGGysvv

CCDMEED-EDVEERTLVVQYEKEKEFTVTHHL-YKSWSMCSVPENSKTLLKLIKNV
  | .    .   |.| .   . .|  | . | . ||   ...  .  |.... .|
lldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldv

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 469-652 4.6e-09 30.7 In-house 30-210 (285) alignment
Range on Protein: 469-652
Range on HMM: 30-210/285.0
TDYVKKHSLEQREELPLVMATRVPLNVHGsrltSDFFHANRIKCPNGLQ--LILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrM
| |  .  |..  ..  .  ||| |. |      |. ||. .. |   |   | || || .      |.  ||  . ||......||  . |   .    
tayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpe......tlsdfwhmiyqekiayvlmlctlfeggve...k

FCKYFPESADGIVKIGGFKISCCDMEEDED---VEERTLVVQYE-KEKEFT-VTHHLYKSWSMCSVPENSKTLLKL---IKNVKCSKTPVIVHG
 . |.||    .||.| ..|.  . .|.     . .   |.. |    |   . |     |     ||... ...|   .|.|.  ..|. || 
calyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhc

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 495-643 5e-09 30.4 In-house 52-196 (297) alignment
Range on Protein: 495-643
Range on HMM: 52-196/297.0
VHGSRLTSDFFHANRIKCPN---GLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDM
. ..   .|.  |. .  |.    |. ||.| ||..      ||  ||  | .. |  |||. ...|.  .       |.|.. ..  | | . .     
llrviterdyinadyvvfpdeeadlkyilaqGplsa......tvddfwtlvaeqdvrvivmvaklqedGrd...kcapywpsvvqerlkagdvvveflss

EEDE--DVEErTLVVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNV-KC
  ||   |   | .  . ....  |.|  . ||    || . . | ..  .|  |
tsdefdrvil.telqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 488-645 1e-08 29.7 In-house 62-211 (325) alignment
Range on Protein: 488-645
Range on HMM: 62-211/325.0
ATRVPLNVHGSRLTSDFFHANRIKCPNGLQL-ILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrmFCKYFPESADGIVKIGGFKI
 .|| |.  .    ||.. |. ..   . .  . .|.||      ..|.  .|  | . | . .|.| ...... .     ..|.|.     .. ||...
ksrvvletkkddpssdyinasylrddkkkdvflaaqaPl......tatindlWrlvldWrcsvvvvlneldlgkdr....cavywpkemgksktfGglev

SCCDMEEDEDVEERTLVVQYEKEK-EFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSK
.   .||  |   | | |.  |.    .|    ..||    |..   ||. ... ||  .
klrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

subfamily_ptpA1_pd Subfamily ptpA1 481-659 5.3e-08 27.0 In-house 54-232 (418) alignment
Range on Protein: 481-659
Range on HMM: 54-232/418.0
EELPLVMATRVPLNVHGSRLTSDFFHANRIKCPNGLQLILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEE-----DANWNR-MFCKYFPES
 ..  |  ||| |.    .  ||.  || |      |.| || ||        |.  ||  | ..|.  |||| . .|.     |  |   .  . |   
tnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgpl......pntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiy

ADGIVKIGGFKISCCDMEEDEDVEE--RTLVVQYEKEKEfTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPvIVHGISRNIDL
 .|   .| . .   .. .| . |   | . . .| |    .|.. |. |    .|. .. . .|....   .   |.    ||. .
gngnevfgtysvelveviqdpereiitrnirltfegetr.ditqyqyegwpdhnipdhtqpfrqllhsitnrqnq.iipssdrnvpi

0036282 (Phosphotyrosine protein) phosphatases II 517-651 7.2e-08 27.8 In-house 18-110 (174) alignment
Range on Protein: 517-651
Range on HMM: 18-110/174.0
QLILTQSPLHkildkastvfkFWWAVRQERVTHIVMLGQVNEedaNWNRMFCKYFPEsadgivkiggfkisccdmeededveertlvvqYEKEKEFTVTH
 ||..| ||            ||  ......|..||| . .|   . . ... |.||                                . .  | .. .
rliagqgpla...........fwemlkelgittvvmlleeke...lglykcinywpe................................lredlerlgiq

HLYKSWSMCSVPENSKtLLKLIKNVKCS-----KTPVIVH
.||  |   .||. |. ||...| |.       . ||.||
ylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

0043147 (Phosphotyrosine protein) phosphatases II 503-651 7.4e-08 27.8 In-house 6-106 (172) alignment
Range on Protein: 503-651
Range on HMM: 6-106/172.0
DFFHANRIKCPNGL-QLILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGQVneedanwnrmfckyfpesadgivkiggfkisccdmeededveert
|. .|. ....    ..| || |        .|. .||  .... .||||.| .                                              
dyinasyldlyyipdrfiatqgp......lrntladfwrmlkelgithivnltel.............................................

lvVQYEKEKEFTVTHHLYKSWSMCSVPeNSKTLLKLIKNVKC-----SKTPVIVH
  . . .  | .. ..|| .|   .|| ... ||.... ..      .. ||.||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVH

0051429 (Phosphotyrosine protein) phosphatases II 502-651 1.2e-07 27.2 In-house 4-156 (272) alignment
Range on Protein: 502-651
Range on HMM: 4-156/272.0
SDFFHANRIKCPngLQ------LILTQSPLHKildkasTVFKFWWAvRQERVTHIVMLGQVNEEDANW-----N--RMFCKYFPESADGIVKIGGFKISC
|. ..|. .. .   .      |.... ||.       |.  ||.  .......||.| ...| ...         | ..  ......  . .| . . .
sgyiNardvggy..grvvkpgrlyrsggplpl......taadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtl

CDMEEDEDVEERTLVVQYE--KEKEFTVTHHLYKSWSMCSVP-ENSKTLLKLIKNvkcsKTPVIVH
  .|  .|.  |.|.. ..   .. ..|.| .| .|   .|| |  ..||.|. .    . ||.||
lseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld....ggpvlvH

subfamily_eak_pd Subfamily eak 532-642 1.3e-07 25.3 In-house 103-208 (332) alignment
Range on Protein: 532-642
Range on HMM: 103-208/332.0
ASTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPESADGIVKIGGFKISCCDMEEDEDVEERTLVVQYEKEKeFTVTHHLYKSWSMCSVPENS
 . || ||  | ...   ||.| .  |.. .    . ||||. .   .| | ... . .  . . .| | |...   |    | |. .  |.  ..|   
edkvfafwqmvleqkspaivqlledvelkle...ksdkyfpdktreelkfGildverkefvkrniletrllelskGnet.hrvlhykvfGwtettlpkye

kTLLKLIKNVK
  .| | | .|
.dflalrkvmk

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 470-598 1.8e-07 24.9 In-house 47-165 (302) alignment
Range on Protein: 470-598
Range on HMM: 47-165/302.0
DYVKKHSLEQREELPLVMATRVPLNvhgsRLTSDFFHANRIKCP-NGLQLILTQSPLHkilDKASTVFKFWWAVRQERVTHIVMLgqVNEEDANWnrMFC
 . |. .  | |..|.. ...| |.        .. .| ... |  . ..||.| |     | .. | .|| .| ||.....|.|  | ||. .    . 
afkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkv...dsedsveeFWrmvfqekivsvvil..vgeeelkk..tls

KYFPESADGIVKIGGFKISCCDMEEDEDVE
..||. ..  .. | . .     |. |. .
elfpkksgdykeygkmfvNnrkVekaeeek

0051082 (Phosphotyrosine protein) phosphatases II 502-651 1.8e-07 26.4 In-house 3-98 (151) alignment
Range on Protein: 502-651
Range on HMM: 3-98/151.0
SDFFHANRIKcPNglqLILTQSPLHkildkastvfKFWWAVRQERVTHIVMLGQVNEEDanwnrMFCKYFPESAdgivkiggfkisccdmeededveert
||.......  ..   |.... ||.           |.  .... ...||.| .  | .     .. .|.||                            
sdyinfsyvt.gg...lyrsggpla..........dflellkelgiktivnlrseeerg.....ycpeylpelg..........................

lvvqyekekeFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCS-KTPVIVH
          ..|.|  . .|.  ..|.. ...|.... .    . ||.||
..........ievlhipildwpdpglplsfdavleflellldkkngpvlvH

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 464-562 7.7e-07 23.0 In-house 42-134 (310) alignment
Range on Protein: 464-562
Range on HMM: 42-134/310.0
KSVGMTDYVKKHSLEQREELPLVMATRVPLNVHGSRLtSDFFHANRIKCpNGL--QLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDA
 |. .  | |.   ..  ..    ..|| |..  ||   |. ||| .|  | |   .| .| || .      |.  ||  . |||   |..| .| ||  
ssltyeaykkymhknrysdvvcldtsrvklkidksry.edyihanyvkt.nylrstficsqgplqh......tiidfwrmifqeraesilllckvgeegr

N
 
p

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 519-642 1.3e-06 23.2 In-house 71-179 (284) alignment
Range on Protein: 519-642
Range on HMM: 71-179/284.0
ILTQSPLHkildkaSTVFKFWWAVRQERVTHIVMLGqvneedanwNRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKE-FTVTH
| || ||        |.  ||  . . ... ||.|          . . ..|.|   .. .| . ||..   .|| |.   | . .    |||.  ... 
iatqGPld......ntladfWrmiweyncstivllt.........kdkcsqywpl..kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirq

HLYKSWSMCSVPENSKTLLKLIKNVK
. .. |    ||. .  |..|.|.|.
fhflgwpdvgvpdypsdlmrlvkkvr

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 519-642 1.5e-06 22.8 In-house 107-215 (319) alignment
Range on Protein: 519-642
Range on HMM: 107-215/319.0
ILTQSPlhkildKASTVFKFWWAVRQERVTHIVMLGqvneedanwNRMFCKYFPEsaDGIVKIGGFKISCCDMEEDEDVEERTLVVQY-EKEKE-FTVTH
| .| |      .  |.  ||  . . ... ||.|          . . ..|.|   .. .| . ||..   .|| ..   | . .    |||.   .| 
iaaqGP......ldntladfWrmiweyncstivllt.........kdkcsqywpl..kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitq

HLYKSWSMCSVPENSKTLLKLIKNVK
. .. |    ||. .  |..|.|.|.
fhflGwpdvGvpdypsdlmrlvkkvr

subfamily_CG42327_pd Subfamily CG42327 487-644 2e-06 21.7 In-house 41-193 (319) alignment
Range on Protein: 487-644
Range on HMM: 41-193/319.0
MATRVPLNVHGSRLTSDFFHANRIKCPNGLQL--ILTQSPLhkildkASTVFKFWWAVRQERVTHIVMLGQVNEEDAnwnRMFCKYFPESA--DGIVKIG
  ||| |.  |.   . ...|. .. ..  .   | .| .|       ..  .||  | . .   || | .. |      ..  .|.| ..  |.    |
PetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsl......edsssdfwrtvweqqsrvivqltdlselGi...kvcaeylPtketldntslyG

GFKISCCDMEEDEDVEERTLVVQ-YEKEKEFTVTHHLYkSWSMCSVPENSKTLLKLIKNVKCS
 ....  . | ..     ||...  .||.   .||. |  |  . || . ..|. .. .|. |
dilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 504-652 3.5e-06 20.9 In-house 69-216 (312) alignment
Range on Protein: 504-652
Range on HMM: 69-216/312.0
FFHANRIK-CPNGLQLILTQSPLHKildkasTVFKFWWAVRQERVTHIVMLGQVNEEDANwnrMFCKYFPEsADGIVKIGGFKI---SCCDMEE----DE
. ||| .| | .  ... ||.||..      |. .||  .     | |..|  . |. ..     .||  .   |.|..   ..   .| ..|      .
yihanfvkictkperfvctqgplen......tcthfwqlalslgstsiillcgfvedgse...kcakyisd.ivgfvdledhrvyteycteieiggkskd

DVEERTL-VVQYEKEKEFTVTHHLYKSWSMCSVPENSKTLLKLIKNVKCSKTPVIVHG
 .  | | ||     .|  . |. . ||    .|.   | |.|.  ||  | ||| | 
kithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahc

0046846 (Phosphotyrosine protein) phosphatases II 500-652 3.7e-06 22.3 In-house 10-116 (176) alignment
Range on Protein: 500-652
Range on HMM: 10-116/176.0
LTSDFFHANRIKCPnglqliltqSPLHKILDKASTVFKFWWAVRQERVTHIVMLGQVNEEDANWNRMFCKYFPESADgivkiggfkisccdmeededvee
| .|. .|| | ..          |. .  .  .|. .|.  ......|..|.| .  | .  .   ..... .                          
ldldyinanlilgs.........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

rtlvvqyekekeftvtHHLYKSWSMCSVPENsKTLLKLIKNV---KCSKTPVIVHG
                ..|.  |   .||.  . ||.|.. .     .. ||.|| 
................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHC