Gene Y39A3A.4 in Caenorhabditis elegans

Synonym: CELE_Y39A3A.4, CELE_Y39A3A.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP213_AA protein Get Run
CeleP213_AA_40-329 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 32-267 9.8e-169 554.7 In-house 3-241 (310) alignment 
Range on Protein: 32-267
Range on HMM: 3-241/310.0
TEEDHLQYLKALENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGP
|.. ||.|||||||||..||||||.||||||||||||||.||||.||.||||||||.||||||.|||||||||||..|||||||||||||||||||||||
tddhhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgp

LQHTIIDFWRMIFQERAESILLLCKVGREGRPR---YWPSLGVTETYGCIRVTNFSESSEEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPD
|||||||||||||||||||||||||||.||||.   ||||||||||||||||||.||||||||||||||||||||||||||||||..|||||||||||||
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

CGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKDRLYVVC
.|||||||||||||||||||||||||||||||||||||.
rgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvv
0051299 (Phosphotyrosine protein) phosphatases II 42-267 3.1e-49 163.3 In-house 9-237 (288) alignment 
Range on Protein: 42-267
Range on HMM: 9-237/288.0
ALENFIFSTEKLGIDGLVKQYRKLDAKQ-DPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDF
 |....  . . |. || .....| ... |..|.. .. ....|||| |....|.|||||.  ..  ..|||.|.|... .|  .||. ||||..|. ||
ellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedF

WRMIFQERAESILLLCKVGREG---RPRYWPSlGVTETYGCIRVTNFSESSeefeiCNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKC
|||..... . |  |.|.   |    ..|||. | ..||| |.||. || .     ..  ....   ...|    . | ..|  . ..|||| ||||   
WrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

HTVPQRLLAQVR----HGPCVVHCSAGKDRLYVVC
. .    |..      .||.|||||||..|  ...
llldflrlvrkalasgggpvvVHCsaGvgRtgtfi
0040438 (Phosphotyrosine protein) phosphatases II 43-262 1.3e-48 161.3 In-house 5-222 (317) alignment 
Range on Protein: 43-262
Range on HMM: 5-222/317.0
LENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|.....   |..  .| .....|.  . .. .. .. . ..|||| |....|.|||||. ...  . |||.|.||.. .|. .||. ||||..|. ||||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIFQERAESILLLCKVGREG---RPRYWPSlGVTETYGCIRVTNFSES-SEEFEICNLAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDekCH
|..... ..|. |..    |     .|||. | | ||| ..||. ||   ..... .| |.   |.          | ..|  . ...||| |||.   .
mvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgds..........esrtvthfhytgWpdhgvpp..sp

TVPQRLLAQVR------HGPCVVHCSAGKDR
.  ...| .||      .||..||||||..|
dllldfleavrealedpggpvlVHCsaGvgR
0036941 (Phosphotyrosine protein) phosphatases II 50-262 1.4e-48 161.1 In-house 7-220 (297) alignment 
Range on Protein: 50-262
Range on HMM: 7-220/297.0
TEKLGIDGLVKQYRKLDA-KQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
...|.. .| |....|.  . ..||.. .. ....|||| |....|..||||   .. . |||.|.||.. .|  .||. ||||..|. |||||..... 
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

ESILLLCKV---GREGRPRYWPSL-GVTETYGCIRVTNFSESS---EEFEICNLAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTVPQ
..|. |...   |||  ..|||.  | . ||| ..||. |...   ... . .| ||.. ..          | ..|  . ...||| |||.   . .  
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..........esrtvthfhytgwpdhgvpespaslldf

RLLAQV------RHGPCVVHCSAGKDR
  |..       ..|| .||||||. |
ielvrkvlkllpsggpvlVHCsaGvgR
0045450 (Phosphotyrosine protein) phosphatases II 35-262 1.8e-48 161.2 In-house 6-247 (307) alignment 
Range on Protein: 35-262
Range on HMM: 6-247/307.0
DHLQYLKALENFIFSTEKLGIDGLVKQYRKLDAKQDP---SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS--RHGDYIHANYV--------KTNYL
...  .. |. ... . . .. || |...||   ...   . .. .. . ..|||| |....|..||||.  ..   ..|||.|.||        .. .|
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

RSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRP---RYWPSLGVTETYGCIRVTNFSESSEE-FEICNLAVTFVpdnvpvdeqPANLEGLR
  .||. ||||..|. |||||..... . |. |..    ||.   .|||. | . ||| ..||. ||. .. . . .| ||             . |...
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.........dgtgesrt

VSLIKWPNWPDCGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGKDR
|  . ...||| |||.   ...    ...       ..||..||||||..|
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR
0050432 (Phosphotyrosine protein) phosphatases II 41-262 2.2e-48 160.5 In-house 27-245 (308) alignment 
Range on Protein: 41-262
Range on HMM: 27-245/308.0
KALENFIFSTEKLGIDGLVKQYRKLDAKQD-PSLTYDAYTKYMHKNRYCDVVCLDNSRVKLkidkSRHGDYIHANYVKTN--YLRSTFICSQGPLQHTII
  |.   .  ..|.. .| .....| .... .. .. .  . ..|||| |....|.|||||    . . |||.|.||..   .|. .||. ||||..|. 
svldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMIFQERAESILLLCKVGREGR---PRYWPSL--GVTETYGCIRVTNFSESSeE--FEICNLAVTFVPdnvpvdeqpaNLEGLRVSLIKWPNWPDCG
|||||..... . |  |.|    ||   ..|||.   | ...|| ..||. || . .  . . .| .|..           . | ..|  . ..|||| |
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlg..........dgesrtvthfhytnWpdhg

VPD--EKCHTVPQRLLAQVRHGPCVVHCSAGKDR
||.  | . .  ...  . ..||.|||||||  |
vPpspeilldflelvrkslpggpivVHCsaGvGR
0046845 (Phosphotyrosine protein) phosphatases II 58-267 2e-47 157.3 In-house 2-222 (284) alignment 
Range on Protein: 58-267
Range on HMM: 2-222/284.0
LVKQYRKLDAKQDP---SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS--RHGDYIHANYVKTN-----YLRSTFICSQGPLQHTIIDFWRMIFQER
| .....|   . .   ||.. .. ....|||| |....|.||||||  ..   ..|||.|.||..      | . .||. ||||..|. |||||.....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AESILLLCKVGREG---RPRYWPSLGVTETYGCIRVTNFSESS-EEFEICNLAVTFVPDnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPD------EKCH
.. |  |..    |    ..|||. | . ||| ..||. ||   . . . .| .|..           . | ..|  . ...||| |||.      | ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.........tgesrtvthfhytswpdhgvppspedlleflr

TVPQRLLAQVRHGPCVVHCSAGKDRLYVVC
.| . | .  ..|| |||||||. |  ...
lvrellenlpgggpivVHCsaGvgRtGtfi
0047943 (Phosphotyrosine protein) phosphatases II 50-267 5.9e-46 152.5 In-house 6-223 (273) alignment 
Range on Protein: 50-267
Range on HMM: 6-223/273.0
TEKLGIDGLVKQYRKLDAKQD-PSLTYDAYTKYMHKNRYCDVVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
...||...| .....|   ..  . .. .. ....|||| |....|.|||||   .. . |||.|.||.. .|  .||. ||||..|. |||||......
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ESILLLCKVGREGR---PRYWPSLGV--TETYGCIRVTNFSESS-EEFEICNLAVTFVPdnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDEKCHTVPQR
. |  |...   ||   ..|||. |   ..||| ..||. || . . . . .| .|..           . | . |  . ...||| |||.   . .   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg..........tgesrtvthfhytgwpdhgvppslesllefi

LLAQV------RHGPCVVHCSAGKDRLYVVC
 |..       ..|| |||||||. |  ...
elvrkalealpsngpvvVHCsaGvgRtgtfi
0039614 (Phosphotyrosine protein) phosphatases II 39-262 2.2e-45 150.8 In-house 15-235 (297) alignment 
Range on Protein: 39-262
Range on HMM: 15-235/297.0
YLKALENFIFSTEKLGIDGLVKQYRKLDAKQDPsLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS--RHGDYIHANYVKTNYL-RSTFICSQGPLQHT
.|..|. ... . .... .| ... .|   ...  .. .  . ..|||| |....|.||||||  ..   . |||.|.||.. .|   .||..||||..|
plsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IIDFWRMIFQERAESILLLCKVGREG--RPRYWPSLGVteTYGCIRVTNFSES-SEEFEICNLAVTFvpDNVPvdeqpanlegLRVSLIKWPNWPDCGVP
. |||||..... ..|. |.|    |   ..|||. |   ||| ..||. ..   . . . .| ||   .. .          . |  . ...||| |||
vedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..nges..........rtvthfqytgwpdhgvp

DEKCHTVPQRLLAQV------RHGPCVVHCSAGKDR
.   .      |..       ..||..||||||..|
pslellleflelvrealaelpkggpvlVHCsaGvgR
DSPc_SM00195 59-267 2.9e-45 150.0 In-house 3-213 (263) alignment 
Range on Protein: 59-267
Range on HMM: 3-213/263.0
VKQYRKLDAKQDP-SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
 ....||.... | . |  .  | ..|||| .... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VGRE---GRPRYWPSL-GVTETYGCIRVTNFSESSEE--FEICNLAVTFVPDnvpvdeqpanLEGLRVSLIKWPNWPDCGVPD--EKCHTVPQRLLAQVR
   .      ||||.  | .||.| |.|.. .. ...  ... .| .|.  .           |  .|  ... |||| ||||  ...  . . .  . .
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksks

--HGPCVVHCSAGKDRLYVVC
  .||.||||||| .|  ...
tssgpivVhCsaGvgRtgtfv
PTPc_SM00194 59-267 2.9e-45 150.0 In-house 3-213 (263) alignment 
Range on Protein: 59-267
Range on HMM: 3-213/263.0
VKQYRKLDAKQDP-SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
 ....||.... | . |  .  | ..|||| .... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VGRE---GRPRYWPSL-GVTETYGCIRVTNFSESSEE--FEICNLAVTFVPDnvpvdeqpanLEGLRVSLIKWPNWPDCGVPD--EKCHTVPQRLLAQVR
   .      ||||.  | .||.| |.|.. .. ...  ... .| .|.  .           |  .|  ... |||| ||||  ...  . . .  . .
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksks

--HGPCVVHCSAGKDRLYVVC
  .||.||||||| .|  ...
tssgpivVhCsaGvgRtgtfv
0043336 (Phosphotyrosine protein) phosphatases II 43-262 6e-45 149.2 In-house 7-223 (278) alignment 
Range on Protein: 43-262
Range on HMM: 7-223/278.0
LENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|....    . .  .| ... .|.  . .. .. .. . ..|||| |....|.|||||. .... . |||.|.||..     .||..||||..|. ||||
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

MIFQERAESILLLCKVGREG---RPRYWPslGVTETYGCIRVTNFSES-SEEFEICNLAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDekCH
|..... ..|. |..    |     .|||  | ..||| ..||. .|   . . . .| ||   |.          | . |  . ...||| |||.    
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdg..........esrtvthyhylgwpdhgvpe..sl

TVPQRLLAQ------VRHGPCVVHCSAGKDR
.  ...| .       ..|| .||||||..|
sllldflkavrealedsngpvlVHCsaGvgR
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 265-331 1.2e-44 147.1 In-house 61-127 (310) alignment 
Range on Protein: 265-331
Range on HMM: 61-127/310.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
|||||.|||||||||||..||||||||||||||||||||||||||||||||||||||||||||||||
vvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck
0045098 (Phosphotyrosine protein) phosphatases II 64-262 1.1e-43 145.0 In-house 16-219 (278) alignment 
Range on Protein: 64-262
Range on HMM: 16-219/278.0
KLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKlkidksrhgDYIHANYVKTNylRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKV---GRE
.|   .  . |.  | . ..|||| |....|.||||         |||.|.|...   . .||. ||||..|. |||||..... ..|. |...   |||
llllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

GRPRYWPSlGVTETYGCIRVTNFSESSEefeicNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQV-------------
  ..|||. | ..||| ..||..||.       .  .. .   . .  ....|| . |  .....||| |||..  ..  ..|| ..             
kcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

------RHGPCVVHCSAGKDR
      ..||..||||||..|
slllldsggpvlVHCsaGvgR
0040439 (Phosphotyrosine protein) phosphatases II 74-262 1.4e-41 138.1 In-house 4-192 (249) alignment 
Range on Protein: 74-262
Range on HMM: 4-192/249.0
TYDAYTKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWPSl
..  . . ..|||| |....|.|||||.| ..  ..|||.|.|... |   .||. ||||..|. |||||..... ..|. |..     ||.  .|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GVTETYGCIRVTNFSESSeE--FEICNLAVTFVpdnvpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGKD
| . .|| ..||..|. . .  . . .| .|..           . | ..|  | ...||| |||.   ...    ...       ..||..||||||..
ggsleygdftvtllsvev.kddytvrtleltnl..........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

R
|
R
Y_phosphatase Protein-tyrosine phosphatase 82-262 5e-41 136.0 Pfam-A 2-183 (235) alignment 
Range on Protein: 82-262
Range on HMM: 2-183/235.0
MHKNRYCDVVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGR---EGRPRYWP-SLGVTETYGC
..|||| |... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|...     |  ..||| . . ..||| 
kkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

IRVTNF-SES--SEEFEICNLAVTFVPDNVpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGKDR
|.|..  .|.  ..|. . .| ..   ..          |  .|. . . |||| |||... . .   ...  .   ..||.|||||||  |
ikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgR
Y_phosphatase Protein-tyrosine phosphatase 82-262 5e-41 136.0 In-house 2-183 (235) alignment 
Range on Protein: 82-262
Range on HMM: 2-183/235.0
MHKNRYCDVVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGR---EGRPRYWP-SLGVTETYGC
..|||| |... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|...     |  ..||| . . ..||| 
kkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

IRVTNF-SES--SEEFEICNLAVTFVPDNVpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGKDR
|.|..  .|.  ..|. . .| ..   ..          |  .|. . . |||| |||... . .   ...  .   ..||.|||||||  |
ikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgR
subfamily_PTPRD_pd Subfamily PTPRD 56-262 6.1e-40 132.4 In-house 23-227 (564) alignment 
Range on Protein: 56-262
Range on HMM: 23-227/564.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
  . ..|.|.. .|  . .  ..    .|||| ..|  |.|||.| |...    ||| |.....   | ..| .||||..|| |||||..... ..| .|
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

CKVGREGR---PRYWPSLGvTETYGCIRVTNFS-ESSEEFEICNLAVtFVPDnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDEKCHTVP----QRLLAQ
 |.  .|.    .|||. | ||||| . ||  . |  ...||... .    .         . |   |   .. .||| |||.. .. .      | |..
tkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkk.........ssesreVrqFhFtsWPdhgvpesatslLdlirkvralne

VRHGPCVVHCSAGKDR
  .|| |||||||  |
pdagPivVhCSaGVGR
0042113 (Phosphotyrosine protein) phosphatases II 78-262 7.8e-40 132.2 In-house 6-189 (245) alignment 
Range on Protein: 78-262
Range on HMM: 6-189/245.0
YTKYMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSlGVTE
. . ..|||| |....|..||||. |... . |||.|.||.. .   .||..||||..|. |||||..... ..|. |..    ||   ..|||. | . 
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

TYGCIRVTNFSESSeEFEICNLAVTFVPDnvpvdeqpANLEGLRVSLIKWPNWPDCGVPD-----EKCHTVPQRLLAQVRHGPCVVHCSAGKDR
||| ..||. || . . ...   .. ...         . | . |  . . .||| ||||     ....   .. ||. ..||..||||||..|
tygdftvtllseeh.lddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgR
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 46-262 7.1e-38 125.3 In-house 6-222 (307) alignment 
Range on Protein: 46-262
Range on HMM: 6-222/307.0
FIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQ
..  | . |.. || ..|.|  |.  ..| .|..   .|||| || | |..|. .|.|     |||||||. .      |||.||||. |. .|| |. |
wvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

ERAESILLLCKVGREGR---PRYWPSLGvtetyGciRVTNFSESSEEFEICNLAV-TFVPDNVPVDEQPANLE----GLRVSLIKWPNWPDCGVPDEKCH
|. ||...||||   ..    .|||        |  .   |.|...   . || . .. ||.  ..    ...       .. ..| |||| |||. .  
ekvesvimlckvielakikceqywplee.....g..qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt

TVPQRLLAQVRHGPCVVHCSAGKDR
..      .  . | |||||||  |
ainlleavrydtnpvvvhcsaGvGr
subfamily_PTPRG_pd Subfamily PTPRG 54-260 3.9e-37 122.7 In-house 17-231 (563) alignment 
Range on Protein: 54-260
Range on HMM: 17-231/563.0
GIDGLVKQYRKLDAKQDPS-LTYDA--YTKYMHKNRYCDVVCLDNSRVKLKIDKSRHG--DYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
|  |. ... .|  .  .. |....   ..  .||||...|  |.|||||.     ..  ||| |||..  .    || .||||..|. ||||||.....
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

ESILLLCK---VGREGRPRYWPSlGVTETYGCIRVTNFSEsseEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHT---VPQR
. | .. .    ||.  ..|||.   .|||| ..||  .|   |  ..    |.|  |. ....    . ..|   ....|||.|||. .      | ..
aiivmitnlvergrrkcdvYWPk.desetygalqvtliee...evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

LLAQVR-HGPCVVHCSAGK
  |. .  || ||||||| 
saankaeaGPivvHcsaGv
subfamily_PTPRB_pd Subfamily PTPRB 56-262 4.8e-36 119.3 In-house 25-231 (293) alignment 
Range on Protein: 56-262
Range on HMM: 25-231/293.0
DGLVKQYRKLDA-KQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILL
 .....| .| | ..| . . .  ..   |||| ...  |.||||| ....... ||| |||.. .  .  || .|||| .|. |||||....... |..
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LCKVGREGR---PRYWPSLGVTETYGCIRVTNFSES-SEEFEICNLAVTFvpdnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDEKC------HTVPQRL
| ..  .|.    .|||.   . .|| |.||  .|.  |.. | .|...             . |  .|   ..  ||| |||..        .|| ...
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek............ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

LAQVRHGPCVVHCSAGKDR
  . ...| |||||||  |
ektaskrPivvhCsaGvGR
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 41-262 2e-35 117.5 In-house 12-236 (298) alignment 
Range on Protein: 41-262
Range on HMM: 12-236/298.0
KALENFIFSTEKLGIDGLVKQYRKLDAKQD--PSLTYD--AYTKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHT
.||...   ..| .. |. .....|.. ..  .. ...   ...  .||||.|.. || ||| |.  |.  ..||| | ....   |..|| .|.||..|
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

IIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGvTETYGCIRVTNFSES-SEEFEICNLAVTfvpdnvpvdEQPANlEGLRVSLIKWPNWPDCGV
. |||||. .| ...| .| ..   ..   ..|||. | .|||| |.|.  |.    ......|.|.         ..  . .  .|  ... .||| ||
vedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvsllskeefadlivrklkvs.........kkkee.kerevrqlhftsWpdkgv

PDEKCHTVPQRL---LAQVRHG--PCVVHCSAGKDR
| ...  .  .      | . |  | .|.|||| .|
penatsvldllrkvrasqqqagnkpvivqCsaGvgR
subfamily_PTPN6_pd Subfamily PTPN6 48-262 5.4e-35 115.9 In-house 21-240 (306) alignment 
Range on Protein: 48-262
Range on HMM: 21-240/306.0
FSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYL--RSTFICSQGPLQHTIIDFWRMIFQ
 |.|| |.    .. .. .||.  | .  | .....||||  ..  |..||.|| ..    ||| |||.|..    . ..| .|| |..|. |||||..|
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

ERAESILLLCKV---GREGRPRYWPSLGVTETYGCIRVTNFSESS-EEFEICNLAVTFVpdnvpvdeqPANLEGLRVSLIKWPNWPDCGVPDEKCHT---
| .. |... |    |.|   ||||.   .|.|| |.||| ||.| ..... .| |. .           . |  .|   .. .||| ||| .. .    
ensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.........kkkkeerevfqyhfksWPdhgvpkdpgavLdf

---VPQRLLA--QVRHGPCVVHCSAGKDR
   | ..     . ..|| |||||||  |
ledvnrkqeeleeaeagpivvhCsaGiGR
0037934 (Phosphotyrosine protein) phosphatases II 81-262 6.1e-35 116.3 In-house 10-191 (243) alignment 
Range on Protein: 81-262
Range on HMM: 10-191/243.0
YMHKNRYCDVVCLDNSRVKLkidksRHGDYIHANYVKTNylrSTFICSQGPLQHTIID----FWRMIFQERAESILLLCKV---GREGRPRYWPslGVTe
 ..||||.|....|.|||||       .|||.||...      ..|..||||..|. |    ||||..... ..|. |..    |||. ..|||  | . 
nlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.

TYGCIRVTNFSESSEE-FEICNLAVTFVP-DNVPvdeqpanlegLRVSLIKWPNWPDCGVPDE--KCHTVPQR----------LLAQVRHGPCVVHCSAG
||| ..||. ||.. . . . .| .. .. |...          . |  . . .||| ||||.   .    .           |||  ..||..||||||
tygdftvtllseehlddytvrtlllenldlddlt..........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

KDR
..|
vgR
subfamily_Ptp69D_pd Subfamily Ptp69D 55-263 7.2e-35 115.6 In-house 21-233 (307) alignment 
Range on Protein: 55-263
Range on HMM: 21-233/307.0
IDGLVKQYRKLDAKQDP-SLTYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESIL
  ||.| |.|| |.. . | .  .      |||| |..  |. ||||| |  . . ||| |...|.   . .||..|.|.. || |||||| .   . | 
dfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

LLCKVGREGR---PRYWPSLgVTETYGCIRVTNFSES-SEEFEICNLAVTFVPDNVPvdEQpanLEGLRVSLIKWPNWPDCGVPdEKCHTVP---QRL--
.| ...   |   ..|||    .  || | |.  ||.  ... | .| |. . ....  |     .  .|   .. .|.|  || | ....    ...  
mlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesg..ev...edsrkvvqyhytgWkDskvP.evargllklieqvre

LAQVRHGPCVVHCSAGKDRL
| .  ..| ||||||| .| 
lyklnrsPivvhCsaGvgrs
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 81-262 1e-34 114.7 In-house 48-232 (305) alignment 
Range on Protein: 81-262
Range on HMM: 48-232/305.0
YMHKNRYCDVVCLDNSRVKLkiDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRP---RYWPSLGVTE---T
  .|||| || |||| ||||  . .   .||||||| |      |||.| ||..|  ||| | .|.. |.|..||..   |      |..|    .    
eagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

YGCIRVTNFSESSEEFEICNLAVTFVPDNVPVDEQPANlEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKDR
 .  ...   |||..... . | . | . | | | | . . ..|.  .| .||| |||      .     |.. .|| |||||||  |
ekgqkisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigr
subfamily_PTPN12_pd Subfamily PTPN12 77-267 1.4e-33 111.1 In-house 36-225 (290) alignment 
Range on Protein: 77-267
Range on HMM: 36-225/290.0
AYTKYMHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVT
  .. ..|||| |..  |.|||.|. ... .  ||| ||..|  . . ..| .|||| .|. ||||||.. . | ....|..   |.    ||||. | .
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

ET-YGCIRVTNFSESS--EEFEICNLAVTFVpdnvpvdeqpanLEGLRVSLIKWPNWPDCGVPDEKCHTVP----QRLLAQVRHGPCVVHCSAGKDRLYV
|. .| ..||. .|    ..| |  |.|..              |  .|  ... .||| |||  . . .      | | .  . | |||||||  |  .
elefgefevtleeekavdddflirtLkveaq............kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGt

VC
..
ii
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 42-262 2.8e-33 109.9 In-house 10-234 (305) alignment 
Range on Protein: 42-262
Range on HMM: 10-234/305.0
ALENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTK------YMHKNRYCDVVCLDNSRVKLkiDKSRHGDYIHANYVKTNYLR-STFICSQGPLQH
 .|.|.  .  .|.| | ...|.|     | .|  |.         . |||| || | |.| |||  ||    ||||||||    .    |||.||||..
iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldq

TIIDFWRMIFQERAESILLLCKVGREG---RPRYWPSL-GVT-ETYGCIRVTNFSESSEEFEICNLAVTFVpdNVPV-DEQPanlegLRVSLIKWPNWPD
|| .|| |. |.. | |..|||    |     .|||   |   |  . | | | | |       .. .| .  |.    .|      . |  ..| .|||
tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll..nltysgdqk.....msvrhlqwtewpd

CGVPDekCHTVPQRLLAQVRH--GPCVVHCSAGKDR
 |||   |.     ||. .|    | |||||||  |
rgvpp..ckltslellsairgskvpivvhcsagigr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 50-265 3.6e-33 110.0 In-house 14-229 (318) alignment 
Range on Protein: 50-265
Range on HMM: 14-229/318.0
TEKLGIDGLVKQYRKLDAKQDPSLTYDAYTK-YMHKNRYCDVVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQER
 .. |   | ..| .|. ... . .... ..   .|||| ...  |..||||.  . .   ||| |||.  .  . ..| .|.|| .|| |||||...  
lresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqn

AESILLLCKVGREGR---PRYWPSLGvTETYGCIRVTNfsesSEEFEICNLAVTfvpdNVPVDEQPANlEGLRVSLIKWPNWPDCGVPDEKCHTVP----
.  |..| ..  .|.    ||||| | ...|| ..|.     .||.|. .. .     .. | ..  . |   |   .. .||| |||.. .. .     
savivmltqeeergkakvhryWPskg.srsygklvvel....keevelsdyvlr....efkvtrteee.esrqvrqyhytsWpdegvpesgaslldlvrq

-QRLLAQVRHGPCVVHCSAGKDRLYV
 ..  ..  .|| |||||||  |  |
vskaqqksgagpivvhCsaGvGrtGv
subfamily_PTPN3_pd Subfamily PTPN3 53-265 6.4e-33 108.9 In-house 12-224 (280) alignment 
Range on Protein: 53-265
Range on HMM: 12-224/280.0
LGIDGLVKQYRKLDAKQD-PSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLR----STFICSQGPLQHTIIDFWRMIFQER
|    ...|. .|  |.   ...    .. ..|||| |..  |. |||||  ..   ||| ||||. .         .| .||||..|  |||.|.....
lesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqk

AESILLLCKVGREGR---PRYWPSLGVTETYGCIRVTNFSEsseefeicNLAVTFVPDNVPVDEQPANlEGLRVSLIKWPNWPDCGVPDEKCHTVP----
.. |..|  .  .||    .|||. . . .||...|.  .|        .   ..|  .. . .. .. |  ..  ... .||| ||||.. . .     
sslivmlttlverGrvkChqyWPetedeleygefsvkceke........detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefver

QRLLAQVRHGPCVVHCSAGKDRLYV
 | | .... | ||||||| .|  |
vrklrsgkeePvvvhCsaGigrtGv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 81-262 7.5e-33 108.8 In-house 9-188 (250) alignment 
Range on Protein: 81-262
Range on HMM: 9-188/250.0
YMHKNRYCDVVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG--RPRYWPSlGVTETYGC
  .|||| |.. ||.||| |. .|  .. ||| | ....   |..|| .|||||.|| |||||...| ...|..| ..  ..   ..|||   ..|.|| 
nkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv.ekaekyGd

IRVTNFSES-SEEFEICNLAVTfvpDNVPVDEQpanleglRVSLIKWPNWPDCGVPDEKCHTV-----PQRLLAQVRHGPCVVHCSAGKDR
..|. .|.    .... .| ..    .   ||.        |  ... .||| |||..    .      |.   |.  .| .|.||||  |
vtvsllskeefadytkrklkls...kakkader.......ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 42-262 9.1e-33 108.1 In-house 13-229 (290) alignment 
Range on Protein: 42-262
Range on HMM: 13-229/290.0
ALENFIFSTEKLGIDGLVKQYRKLDAKQDP-----SLTYDAYTKYmHKNRYCDVVCLDNSRVKLKidKSRHGDYIHANYVKTnyLRSTFICSQGPLQHTI
|.|.|  .. | ..|.| |.| .      |        .|. |.. .|||| |||| | .|| ||     .|||.||||||   |...|| .||.|. |.
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntef.kknrykdvvcndktrvilk..dGydGdyvhanyvkG..lkamfiltqGalkdtv

IDFWRMIFQERAESILLLCKVGREGRPR---YWPS-LGVTETYGCIRVTNFSESSEEFEICNLAVTFVpDNVpvDEQPAnleglRVSLIKWPNWPDCGVP
||.|||. ||..  | .||..  .|...   |.|   | . |.| | |.   |.... .|    ..   |    . .       ..  .|   |||  |.
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvr.dkd..sGkeh.....klkhlkikswpdksva

DEKCHTVpqRLLAQVR--HGPCVVHCSAGKDR
  .   .  |.|  .|   || |||||||  |
lstlall..rtlrilrkasGpvvvhcsaGiGr
subfamily_PTPN23_pd Subfamily PTPN23 57-268 4.7e-32 105.9 In-house 16-231 (288) alignment 
Range on Protein: 57-268
Range on HMM: 16-231/288.0
GLVKQYRKLDAKQDPS---LTYDAYTKYMHKNRYCDVVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRS-TFICSQGPLQHTIIDFWRMIFQERAESIL
.| |....|. |||      .  .  .| .|||. |..  |..||||.   . . ||| | .||     . .||..|.||| |. |||.|....... | 
aldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

LLCKVGREGRP---RYWPS-LGVTETYGCIRVTNFSESSEEfeicnlavTFVPDNVPVDEQPANLEgLRVSLIKWPNWPDCGVPD------EKCHTVPQR
.| .    |.|   ||||.  | |...| ..||  |. . |        |.|  .. .. ..|.     ||.... .||. |||.      .  . | . 
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete........thvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldevesa

--LLAQVRHGPCVVHCSAGKDRLYVVCL
     .  . | ||||||| .|  |..|
yeavqrksktPlvvhCsaGvgRtgvfal
subfamily_PTPN9_pd Subfamily PTPN9 44-238 5.8e-32 105.9 In-house 4-195 (297) alignment 
Range on Protein: 44-238
Range on HMM: 4-195/297.0
ENFIFSTEKLGIDGLVKQYRKLDAKQDPS-LTYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|...   .. |. ||.|.| .. ...    ...      ..|||| ||.|.|..||.|. .|.  . |||.||.|     . .||  ||||..|. ||||
eelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MIFQERAESILLLCKVGREGR---PRYWP-SLGVTETYGCIRVTNFSES-SEEFEICNLAVtfvpDNVPVDeqpanlEGLRVSLIKWPNWPDCGVPDEKC
|......  |..  .|  .||    .||| . . .. .| ..|.| .   .|....  | .    .||  .      |  .|.  .   ||| |||..  
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei....knvkte......esrkvthfqflsWPdyGvPssaa

HT
  
sl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 52-259 8.4e-32 105.4 In-house 17-222 (288) alignment 
Range on Protein: 52-259
Range on HMM: 17-222/288.0
KLGIDGLVKQYRKL-DAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAE
. . .|....|..|   ... | |    ..  .|||| ... .|  |||||  .. .  ||| |.|.. .  . ..|..||||..|. |||.........
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

SILLLCKV---GREGRPRYWPSLGVTETYGCIRVTNFSESSEEfEICNLAVTFVpdnvpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQ
 |. | ..   |..   .|||. .  . || . ||  ..  .| .. .  .  .           . . |..   ..  ||| |||. |   .  .   .
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskele.dfvlrkllle..........kkkteleitqyqylaWpdhgvPeskapllellrqvk

VR----HGPCVVHCSAG
|      || .||||||
vanqadtgpiivhCsaG
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 54-262 1.5e-31 104.5 In-house 13-221 (281) alignment 
Range on Protein: 54-262
Range on HMM: 13-221/281.0
GIDGLVKQYRKLDA--KQDPSlTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAES
   |....|.|| |   .... |     . ..|||| ..|  |..|||. . ... . ||| ||.|..      .| .|||. ... .||.|....... 
dnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

ILLLCKVGREGR---PRYWPSLGVTETYGCIRVTNFSESSEEfeicnlavTFVPDNVPVdEQpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLA--
| .. .   .|.    ||||    . .|| ..|.. .|....        |..  .. . |.  . |  .|. ... .||| |||..  . .  |     
ivmvtreieagklkChrYWPddnselkygdvtvkstaeeeka........tyierkfkl.er.esgetreveqlaytaWPdhGvPattkellefrkevlk

-QVR--HGPCVVHCSAGKDR
 . .  . | |.|||||  |
ltekktkaplvihCsaGvGr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 41-262 3.4e-31 103.5 In-house 7-229 (305) alignment 
Range on Protein: 41-262
Range on HMM: 7-229/305.0
KALENFIFSTEKLGIDGLVKQYRKLDAKqDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDF
. |...|.....   .|| .||..|  . . |.  .  ..  .|||. ... ||..|..|. ..| .  ||| |.||..   . ..| .||||..|. ||
ddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf

WRMIFQERAESILLLCKVGREGR---PRYWPSLG-VTETYGCIRVTNFSE-SSEEFEICNLAVTFVPDnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDE
||.|..|. ..|..|.|.  .|.    .|||     .. .| . |.  || . ... . .| ...  .         . |.  |.  .  .||| |||..
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.........dkesrtvlqyqltdWPdhGvpqf

KCH--TVPQRLLAQVRHG---PCVVHCSAGKDR
     .. .|.  . ...   | .||||||  |
atsllslikrvqkdqkkdkgvpllVhCsagvgR
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 46-262 3.8e-31 102.8 In-house 1-213 (281) alignment 
Range on Protein: 46-262
Range on HMM: 1-213/281.0
FIFSTEKLGIDGLVKQYRKLDAKqDPSLTYDAYTK--YMHKNRYCDVVCLDNSRVKLKI--DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
| .|..|. .| . ... .|     ||    .. .    .|||| .. ||| |||.||.   .    |||||||... .|.  .| .||| . |  ||||
famssqkmtlddfkqefsnlpgd.ppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwr

MIFQERAESILLLCKVGREGR---PRYWPslgvTETYGCIRVTNFSESSEEFEICNLAVTfVPDNVPVDEqpanlEGLRVSLIKWPNWPDCGVPDEKCht
||.|| . .|..||..    |     |.|     ... |... ..| | |.  . .  ||    |.  .      |   ..   | .|||  ||.     
miwqenttaivmlcqfletnrekcaeyfp....rnahcclqfdklsvsyedstvnkslvt.trlnlsyeg.....etrlithwlwkewpdwqvpesse..

VPQRLLA--QVRHGPCVVHCSAGKDR
|  ..|   . |  | |.|||||  |
vmlkilrkirarstppvihcsagvgr
subfamily_PTPRA_pd Subfamily PTPRA 79-263 5.1e-31 102.8 In-house 56-242 (330) alignment 
Range on Protein: 79-263
Range on HMM: 56-242/330.0
TKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGRE---GRPRYWPSLGVTeT
 . ..|||. ...  | ||| |   .   . ||| | ...    . .|| .|||...|. ||||||.. .. .|..| ..         .|||. |.  |
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv.t

YGCIRVT-NFSESSEEFEICNLAVTFVPDNVPVDEQpaNLeglrVSLIKWPNWPDCGVPDEKCHTVP----QRLLAQVRHGPCVVHCSAGKDRL
|| |||. . .. .... . .. |. .||.   ...   |    |. ...  ||| ||| |    .      . | |.  || |||||||  | 
yGnirvevedetvlvdytvrkflvqqlpdatrekks..rl....vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrt
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 79-262 9.1e-31 101.9 In-house 26-214 (274) alignment 
Range on Protein: 79-262
Range on HMM: 26-214/274.0
TKYMHKNRYCDVVCLDNSRVKLKIDKSRH--GDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLG--
..  .||||....  .|||| |. ..|..   .|| |||.|  ..   ...  ||||..|. ||||||.||... |..| |.  . .    .|.|     
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

-VTETYGCIRVTNFSE-SSEEFEICNLAVTFVPDNVPvdeqpanleglrVSLIKWPNWPDCGVPDEK------CHTVPQ-RLLAQVRHGPCVVHCSAGKD
 ..|.|| . ... .  . ..... .| .  . ..              |  . ...|||  .||.       .. | . |  .. . .| |||||||  
eiserygdveikvekiverndysvrklvlkylerers............vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiG

R
|
r
subfamily_PTPRK_pd Subfamily PTPRK 82-263 1.5e-30 101.1 In-house 44-224 (314) alignment 
Range on Protein: 82-263
Range on HMM: 44-224/314.0
MHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG---RPRYWPSLgvTETYGC
 .|||. |..  |.|||.|. ||   . ||| |... .    . ||  |||||.|. ||||....|.. ||..| ..  .|     .|||    ||.|| 
reknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tevygd

IRVTNFSESSEEfEICNlaVTFVPDNvpvdEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTV---PQ-RLLAQVRHGPCVVHCSAGKDRL
|.|.  . . .. |. .   .|   .     . .  |   |  ... .||| .|| ..   .    .     . ..|. |||||||  | 
ikvelvetella.elvv..rifrvek....largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 43-262 2.2e-30 100.8 In-house 10-229 (319) alignment 
Range on Protein: 43-262
Range on HMM: 10-229/319.0
LENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|.. .   .. |  .| |....|.  .. ...     .  .|||| ...  |..||.| ..| .   ||| |... .   |. ||  |.||..|| ||||
LkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MIFQERAESILLLCKVGREGR---PRYWPSLGvTETYGCIRVTNFS-ESSEEFEICNLAvtfvpdnvpVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCH
|...|..  ...|.|.  ...    .|||.    |.|| . ||  . |  |...| .|          .... ...|  .|.  .. .||| .||..   
mvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklk.........lnkkssevetRevkhfqyteWpdhdvPekats

TVP--QRL---LAQVRHGPCVVHCSAGKDR
 .   .|.     .  .|| |||||||  |
lldllkrirksrektqsgPivvhCsaGvGR
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 74-263 9.1e-28 92.5 In-house 54-238 (319) alignment 
Range on Protein: 74-263
Range on HMM: 54-238/319.0
TYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCkvgREGRPRYWPSLGV-
|.    .   |||. ...  |...|||. ..     ||| | .|.    .  .| .||||. |. ||||||.. .. .|.||    ..   .|||  .| 
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplkivi

TETYGCIRVTNFSESSEefeicnlavtFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCSAGKDRL
.|  . ..|.   |..|          .|  .. . |.  . .  ..   ..  ||| ||||     .    . | | .  .   . |||||||  | 
keerfkvkvdsveetae..........yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt
0041856 (Phosphotyrosine protein) phosphatases II 82-262 1.3e-27 92.0 In-house 2-122 (182) alignment 
Range on Protein: 82-262
Range on HMM: 2-122/182.0
MHKNRYCDVVCLDNSRvklkidksrHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCkvgregRPRYWPslgvtetygcirvt
..|||| |... |.||         . |||.||..  ..  ..||. ||||..|. ||.||. ...  .|. |.       ..|||              
ldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp..............

nfsesseefeicnlavtfvpdnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDekcH--TVPQRLLAQVRHGPCVVHCSAGKDR
                              .|.   .  ... .||| ||||      ..     .. ..||..||||||..|
..............................ellerlgiqylylpwpDhgvpd...ldelldfieevleeggpvlVHCsaGvgR
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 74-263 1.8e-27 91.6 In-house 18-202 (284) alignment 
Range on Protein: 74-263
Range on HMM: 18-202/284.0
TYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCkvgREGRPRYWPSLGV-
|.    .   |||. ...  |...|||. ..     ||| | ...    .  .| .||||. |. ||||||.. .. .|.||    ..   .|||  .| 
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplkivi

TETYGCIRVTNFSESSEefeicnlavtFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCSAGKDRL
.|  . ..|.  .||.|          .|  .. . |.  . .  ..   ..  ||| ||||   . .    . | | .  .   . |||||||  | 
keerfkvkvdsveesee..........yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 43-260 4.6e-27 89.6 In-house 7-227 (290) alignment 
Range on Protein: 43-260
Range on HMM: 7-227/290.0
LENFIFSTEKLGIDGLVKQYRKLDAKQ-DPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKiDKSRHGD----YIHANYVKTNYLRSTFICSQGPLQHTII
. .|.   .. | .|  .|. .||. . . . |..  ..  ..||. ..|  |. |. |. ..| | |    ||.| |.|    .  .|  |||...|..
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLr.pisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

DFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVTEtYGCIRVTNFSESSEEfEICNLAVTfvpdnvpVDEQPANLEGLRVSLIKWPNWPDCG-V--
|||..| ||.   |..|...  ||.     |||. .... || ....  .|.. . |. .  .        | .. .. .   |   .  ||.. | |  
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierkle.......vknknsagakqsvtqyqitnwdstgkvtn

PDEKCHTVPQRLLAQVRH--GPCVVHCSAGK
|    ... ..   | ..  .. |||||.. 
pqtillvieemyktqrkrgntsivvHCSdtv
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 56-262 5.2e-27 89.6 In-house 24-225 (315) alignment 
Range on Protein: 56-262
Range on HMM: 24-225/315.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|. ..|  .   |   |     ..  .|||| ...  |.|||.|  ...  | ||. ||...    .  .|..|||.  .. ||||..|.|    |..|
ngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml

CKVGREG-R--PRYWPSLgvTETYGCIRVTNFSESSE-EFEICNLAVTFvPDNVpvdeqpAnleglRVSLIKWPNWPDCGVPDEKCHTV------PQRLL
 ..  .  |   .|||      .|| | ||  ||  . |. .  |.|.|  ||.             |  ...  ||| |||      .       |   
tnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvf.gdni......r.....evvqlhytswpdmgvpkytiplmnlirtvkqhht

AQVrhGPCVVHCSAGKDR
..|  |. |||||||. |
nsv..gaivvhcsaGvGr
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 47-262 8.5e-26 85.6 In-house 10-217 (288) alignment 
Range on Protein: 47-262
Range on HMM: 10-217/288.0
IFSTEKLGIDGLVKQYRKLdAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKiDKSRHgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQE
|    . ...|| |.||    .. .  . |.. .   ..|| .. . | .||||. | .    ||.|| | ..  .  .||.| ||. ||  .|.|....
irlvlqiaveglkkeyrds.pneasidiidsfianptrdryenlprcditrvkls.ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmlles

RAESILLLCKVGREG---RPRYWPSLgVTETYGCIRVTNFSESSEeFEICN-LAVTFVPDNVPVDEQPanleglRVSLIKWPNWPDCGVPDEkcHTVPQR
  | |..||..   |      |.||  . |.    |. .    .   .|   . |. .  . ...|.        |  . . .|.| |||..  .  | |
dveyivmlcellekGkeksaeyfPsk.lGekarigrlctvvkkkr.adidklvkvsllriskegeekv......ivkilhlleWdddgvPen..ylsplr

LLAQVR--HGPCVVHCSAGKDR
||  ..  . | |||.|||  |
llevlkslqkPivvhssaGvGr
0051429 (Phosphotyrosine protein) phosphatases II 108-262 1e-25 86.4 In-house 4-163 (272) alignment 
Range on Protein: 108-262
Range on HMM: 4-163/272.0
GDYIHANYVKTNYL---RSTFICSQGPLQHTIIDFWRMiFQERAESILLLCKVG---REGRPRYWP-----------SLGVTETYGCIRVTNFSESSEEF
..||.|..|....    . ....|.|||..|. ||||.  ...  .|. |...    |.. .||||           .   | .||..|||..||.  ..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

eicnlavtFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAqvrHGPCVVHCSAGKDR
        .. ..  .  .  . |...| .. . .||| |||.| .... . ||.   .||..|||||||||
........yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdR
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 64-262 2.4e-25 84.1 In-house 18-216 (285) alignment 
Range on Protein: 64-262
Range on HMM: 18-216/285.0
KLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKidkSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---R
|.     |  || ||      |||.|| |....|| ||    .  |||||....     .||.| .||||  |. |||.||.||.   .|.|| .     
kikgymppnctytayeanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv

EGRPRYWP-SLGVTETYGCIRVTnFSESSEEfeicNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVP-QRLLAQV--RHGPCVVH
|    |.|  ||    .|   .| ..|  ||     .| | .     .. . |. | | .  .. | |||   |..    .   . . .|  .  | .||
ekcalyypeklgevvkfgkyeit.lteckee....aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvh

CSAGKDR
||||  |
csagvgr
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 56-264 1.2e-24 81.6 In-house 15-241 (301) alignment 
Range on Protein: 56-264
Range on HMM: 15-241/301.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS---RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESIL
... .||..|. ..| | |     .  . ||. ... .|. |. ||  ..    . .|| |.|..    .  || .|||...|..||||.|.||.  ||.
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

LLCKVGR---EGRPRYWPS-LGVTETYGCIRVTNFSES-SEEFEICNLAVTFVpDNVP---VD---EQPANLEGLRVSLIKWPNWPDCGV---PDEKCHT
 ...      .   .|||.    .|..| . ||  .|    .| | .|.|.   |      .    .  .. ..  |  ..  .||. ||   |    . 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq.dgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

VPQRLLAQ--VRHGPCVVHCSAGKDRLY
. . . .|  .  || |||||..  |  
iddvihrqqkigggpvvVHCSdtVsrsG
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 44-262 1.7e-24 81.3 In-house 8-224 (287) alignment 
Range on Protein: 44-262
Range on HMM: 8-224/287.0
ENFIFSTEKLGIDGLVKQYRKLDA--KQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
 .|. . .. | .|  .|.  |.   ... ..| .  ..  .|||. ...  || || ||    .| ||| | ....   .  || ...|. .|. .||.
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWk

MIFQERAESILLLCKV---GREGRPRYWPSLGVtETYGCIRVTNFSESSEEfeicnlavTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCG-VPDEKC-
.| ... . |..||.     .|   .|||.     ..|  ...  .|  ..         ..  .. | ..  . . ..|   .  ||.. | |.. .  
liddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevna........gyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

-HTVPQRLLAQVRH--GPCVVHCSAGKDR
   . ..  .| ..  .. |||||..  |
llvieemyktqrkrgntsivvhCsdtvGr
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 80-260 2.1e-24 80.8 In-house 37-221 (287) alignment 
Range on Protein: 80-260
Range on HMM: 37-221/287.0
KYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPR---YWPSLGVTETYG
  ..||||.||. .|..|| |  .     ||| |||| .     .||..|||.  |. ||||.....|. |.... .   |.| .   |||   |    |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

CIRVTNFSESSEEFEICNLAVTFVpdnvPVDEQPANLeglrVSLIKWPNWPDCGVPDE-----------KCHTVPQRLLaqVRHGPCVVHCSAGK
   |. .. .  | | .  |.  .     .. . |..    |  ... .||| ...             | |   .|       || |||...| 
GysvvlldydikePeygvralrli....dletrearv....vkqldllswPdkvlaPtavglirfvldvkqhielarda..sevGPlvvhddvGi
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 80-267 2.9e-24 80.5 In-house 43-228 (315) alignment 
Range on Protein: 80-267
Range on HMM: 43-228/315.0
KYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPS-LGVTET
  ..|||| ... ||..||||  ||.| . ||| | |.|.     ..|.|||||. .. |||||..||.. .| .. |  .. .    .|||   . .  
infkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsve

YGCIRVTNFSESSEEFEICNLAVTFVPDnvpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTVpqRLLAQVR------HGPCVVHCSAGKDRLYVVC
.| |.|. .| ..    .    ||   .           |  .|.  .. .||| ||. .    .  .|. .|.      . . .||||||  |  ||.
fGsikvellsleadtdgvarklvtrkse...........esrtvtqfqftewPdkGvdkqtssll..klikevkadngkkefsllvhcsaGvGrtGvvi
subfamily_egg_pd Subfamily egg 69-194 3e-24 80.3 In-house 28-161 (307) alignment 
Range on Protein: 69-194
Range on HMM: 28-161/307.0
QDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC-KVGREGRPRYW
.. |||  |   ...| |   | | | |||||.. . .. .|.||||.|| . |  .||..| ||. |  |||||.|||. . |..|  ..  |  . ||
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyyw

PSLGV---TETYGCIRVTNFSESSE---EFEICN
|           | .|..|.   |.    | . .
pkaesdslvtvpGslrienlkvdskadplfrvtk
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 63-263 4.3e-24 80.0 In-house 2-211 (270) alignment 
Range on Protein: 63-263
Range on HMM: 2-211/270.0
RKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVK-TNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGRE
..|| ..  . .  ....  . ||| |..   ..||.|. ...  .  || ||||.  .  . ..|...|||. |. .|||||..|....|... ..  .
keldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

GR---PRYWPSLG---VTETYGCIRVTNFSESSEEFeicnlavtFVPDNVPVDEQPanlEGLRVSLIKWPNWPDCGVPDEKC-HTVPQRLL---AQV---
||    ||||.     |. ..| |.|.. ||. ||.        ..  .. . |.    |  |.    . .||| ||| |.   . .. ||   ..|   
grkkCerYWpaepkekvkledgkikvlalseekeeg........yiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrs

-----RHGPCVVHCSAGKDRL
     . .|..|||||| .| 
ekeldkaePllvHcsaGvgRt
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 60-267 6.2e-24 79.4 In-house 13-217 (283) alignment 
Range on Protein: 60-267
Range on HMM: 13-217/283.0
KQYRKLDAKQDPSlTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVK--TNY-LRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.....|   . .. . ..  .  .|||. ..|  |. ||.|| .     ||| | ..    .|     .| .|.||..|..|||.|.|.|.. .|..| |
evlkrlsvpdlda.diasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

VGREGR---PRYWPSLGvTETYGCIRVTNFSES-SEEFEICNLAVTFVpdnvpvdeqPANLEGLRVSLIKWPNWPDCGvPDEKCHTV-----PQRLLAQV
.  . |    .|||. | .| ||   ||   |  |. | | .| .             .  . | ..  .  .| ..| ..    ..      . |  . 
lqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvn.........ssakstlllahyqvidWleyg.eqaiinslvkfnkvislqtes

RHGPCVVHCSAGKDRLYVVC
..|| |||||.|  |  | .
kkgPivvhCstgiGrtavfi
0049772 (Phosphotyrosine protein) phosphatases II 66-262 6.4e-24 80.7 In-house 31-225 (314) alignment 
Range on Protein: 66-262
Range on HMM: 31-225/314.0
DAKQDPSLTYDAYTKYMHKNRYCDVVCLDnSRVKLKIDKSRHGDYIHANYVKTNylrSTFICSQGPLQHTIIDF----------WRMIFQERAESILLLC
 . .. ...   . . ..|||| |... | .||.|.    .  |||.|.||..     .||..||||..|..||          |||....   .. . .
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------KVGREGRPrywpslgvtetygcI----------RvtnfsesseefeicnlavtfvpdnvpvDEQ--PANLEGLRVSLIK
                       .  |..                         .                           .|.  |  .|.| . .. 
srdevladelsrLdaAlgKtpllildgng..............neptaadlellk...........................eelydpelferlgikylr

WpNWPDCGVPDEKCHTVPQRLLAQ-VRHGPCVVHCSAGKDR
. ..|| ..|...      ... .  ..|| .|||.|||.|
i.pvpDgsaplledfdeflefieeadkggpvlvHCkaGkgR
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 56-262 6.7e-24 79.6 In-house 23-234 (325) alignment 
Range on Protein: 56-262
Range on HMM: 23-234/325.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
||. ...  | ...  . .  .  . . |||. .|| ||.||| |.  | . . ||| |.|....  . .|. .| || .|| |.||.... |.  ...|
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl

CKV--GREGRPRYWPSL-GVTETYGCIRVTNFseSSEEFeiCnlavTFVPDNVPVdEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVP---------QR
 ..  | .    |||   | . |.| ..|     . ||.        .|   . |  |. . | . |   ..  |.| ||.   .  ..         .|
neldlgkdrcavywpkemgksktfGglevklr..tieei..s....dyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

LLA-QVRHGPCVVHCSAGKDR
. |     .| .||||||  |
vtantkastpilvhcsaGvGr
subfamily_PTPN13_pd Subfamily PTPN13 79-263 9.7e-24 79.1 In-house 35-216 (273) alignment 
Range on Protein: 79-263
Range on HMM: 35-216/273.0
TKYMHKNRYCDVVCLDNSRVKLKIDKSrhgdYIHANYVKTNYLRST--FICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVTE
 . ..|||| .|.  |..||||. . .    || |...| .    .  .| .|||| .|. |||.|... .|| | .. .   .|.    ||||.    .
kenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

T--YGCIRVTNFSesseefeICNLAvTFVPDNVPVDEQpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQ-RLLAQV--RHGPCVVHCSAGKDRL
.  .. ..|..         . .|  .||  .. | .. .  |  .|. ... .||| ||| .  . .   . ....   .|| |||||||  | 
lkvsnrlevellk.......vqkld.gfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrs
subfamily_PTPN1_pd Subfamily PTPN1 79-268 9.8e-24 78.6 In-house 30-220 (290) alignment 
Range on Protein: 79-268
Range on HMM: 30-220/290.0
TKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVTETY
 .   .||| ||   | ||.||. ..    ||| |. |. . ..  .| .|||| .|.  ||.|...... ....| ||  ...    .|||.   ... 
penrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

G----CIRVTNFSE-SSEEFEICNLAVTFvpdnvpvdeqPANLEGLRVSLIKWPNWPDCGVPDEKCHTVpqRLLAQVR--------HGPCVVHCSAGKDR
      ..|.  || ..... .  | ..               |   ..  ..  ||| |||.     .  ..| .||        .|| |.|||||  |
lledtklkvkliseerksyytvrllelen..........lktqetreilhfhyttwpdfgvpespaafl..kflfkvresGslssdvGpavihcsaGiGr

LYVVCL
   .||
sGtfcl
DSPc_SM00195 265-331 1.2e-23 79.2 In-house 35-102 (263) alignment 
Range on Protein: 265-331
Range on HMM: 35-102/263.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
ilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte
PTPc_SM00194 265-331 1.2e-23 79.2 In-house 35-102 (263) alignment 
Range on Protein: 265-331
Range on HMM: 35-102/263.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
ilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 83-267 1.3e-23 77.9 In-house 45-227 (515) alignment 
Range on Protein: 83-267
Range on HMM: 45-227/515.0
HKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRP---RYWPS-LGVTETYGC
.|||| ... .|..||||  |. . | ||. | |...     ..|.||||.. .. ||||...||.   | .. |  .. .    .|||   | .  .| 
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

IRVTNFSESSEEFEICNlAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTvpQRLLAQVR--H----GPCVVHCSAGKDRLYVVC
|.|   | ..    |    .| . ..          .   |   .. .||| ||| .       .|. .|.  |     | ..|||||  |  ||.
ikvelvsleactggikr.kltvlkgd..........dsrtvtqfhfteWPdkGvpkhtssl..lklikevkadhgqythpliihcsaGvGrtGvvi
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 81-267 3.4e-23 77.2 In-house 51-235 (297) alignment 
Range on Protein: 81-267
Range on HMM: 51-235/297.0
YMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLrsTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG--RPRYWPSLGVTEtYGC
 ..|.|| ...  | |||||.|  .    ||. | .||.|     .|..| | . |. |||.|...|..  |..| .  ..     |||.  |||. .| 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt.fGd

IRVTNFSESSEEfeicnlavTFVPDNVPVDEQPANLEGLrVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVR-------HGPCVVHCSAGKDRLYVVC
. |.  | |. |         |.  .. | .. |  . . |   .. .|||  |. ..  .  . |. .||       .|| .|||.||  |  |..
vsvvllsvsere........Gfikrelevtkgkakarrv.vkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll
subfamily_ptpA1_pd Subfamily ptpA1 57-267 5.6e-23 76.3 In-house 22-247 (418) alignment 
Range on Protein: 57-267
Range on HMM: 22-247/418.0
GLVKQYRKLDAKQDPSLTYDAYTKY-MHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRsTFICSQGPLQHTIIDFWRMIFQERAESILLL
 . ...| |.    || | .   |.   |||| ... .. .||.|| |.     ||| |||.   | .  |||.||||  || |||||....|.  |..|
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivml

CKVGREGR---PRYWPSLGVTETYGCIRVTNfsESSEEFEICNLAVTFVPDNVP-VDEQPANLEGL--RVSLIKWPNWPDCGVPDEK------CHTVPQR
 .   . |    ||||     | .      |  |    . .  . |   |.      .    .||    ..  ..  |||  .||         |.. .|
sresencrikcdrywpeqiggeqfsiygngn..evfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

----LLAQVRHGPCVVHCSAGKDRLYVVC
    . .  |  | .||||||  |   .|
qnqiipssdrnvpiivhcsagvgrtgtfc
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 71-277 1e-22 75.2 In-house 40-241 (439) alignment 
Range on Protein: 71-277
Range on HMM: 40-241/439.0
PSLTYDAYTKymHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRprYWPSL
 ||. . | .   |||| ||. .| .|| | .|    |  || |||.|  |    .| .||| ..|  ||||.......  |. |...    .  |||| 
aslaaqeydq..tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsd

GVTeTYGCIRVTnfseSSEEFEICNLAVTFVpdNVPVDEQPANLEgLRVSLIKWPNWPDCGVPDEKCHTVPQ-RLLA----QVRHGPCVVHCSAGKDRLY
. .  || | |        . |. | ..  .  .|  . . .. |   |  ...  |||  || .  | .   | .     .   || |||||||  |  
aev.cygdiavr....vdrnielpnyvirgf..kvfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtG

-VVCLDNSRVKLKI
 ...|| .  .||.
tiialdialeqlkl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 75-270 1.1e-22 75.1 In-house 37-230 (312) alignment 
Range on Protein: 75-270
Range on HMM: 37-230/312.0
YDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSlgVTET
  |. |.   ||| .. | |  |  |  |.     |||||.||       |.|.||||. |.  ||.. .   . ||.||| .  .|  .      ... 
ctaflkfkdlnrypniqcwdrgrftlagden...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcaky..isdi

YGCIRVT---NFSESSEEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDeKCHTVpQRLLAQVRH--GPCVVHCSAGKDRLYVVCLD
 | . .     ..|.  | ||   .   .   |      |  .  ..   .|  ||| |.||  | |  .|||. |..   | . |||||  |   ..| 
vgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpd.scdta.lrllsavkkdkkpviahcsagvgrtgtlali

N
.
e
0051299 (Phosphotyrosine protein) phosphatases II 265-331 1.3e-22 76.0 In-house 58-125 (288) alignment 
Range on Protein: 265-331
Range on HMM: 58-125/288.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||.  ..  ..|||.|.|... .|  .||. ||||..|. |||||..... . |  |.|
ilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltk
0036941 (Phosphotyrosine protein) phosphatases II 265-331 1.4e-22 75.8 In-house 48-111 (297) alignment 
Range on Protein: 265-331
Range on HMM: 48-111/297.0
VVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|..||||   .. . |||.|.||.. .|  .||. ||||..|. |||||..... ..|. |..
ilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte
0050432 (Phosphotyrosine protein) phosphatases II 265-331 1.5e-22 75.8 In-house 77-141 (308) alignment 
Range on Protein: 265-331
Range on HMM: 77-141/308.0
VVCLDNSRVKLkidkSRHGDYIHANYVKTN--YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||    . . |||.|.||..   .|. .||. ||||..|. |||||..... . |  |.|
ilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtk
0046845 (Phosphotyrosine protein) phosphatases II 265-331 2.6e-22 75.0 In-house 37-110 (284) alignment 
Range on Protein: 265-331
Range on HMM: 37-110/284.0
VVCLDNSRVKLKIDKS--RHGDYIHANYVKTN-----YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.||||||  ..   ..|||.|.||..      | . .||. ||||..|. |||||....... |  |..
ilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlte
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 83-263 2.8e-22 74.1 In-house 5-186 (237) alignment 
Range on Protein: 83-263
Range on HMM: 5-186/237.0
HKNRYCDVVCLDNSRVKLKIDKSRhGDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKV---GREGRPRYWPSLGVTETYGCI
 |||| ..|. | ||| ||   |   ||| |.|.|  .    ..|..||||. .  |||.|..||.   |..|  .    ..   .||||    ..|| .
iknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvl

RVTNfsESSEEFEICNLAVTFVPDNVPVDeqpanleGLRV-SLIKWPNWPDCGVPDEKCHTV--PQRLLAQVRH----GPCVVHCSAGKDRL
 |.      |||    .    .  .. .        ..|.    ..  ||| |||.. .  .   .... . .|    || ..|||||  | 
tvsl..kkkeefsdytvrslllskrltlk.......evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrt
subfamily_PTPN14_pd Subfamily PTPN14 62-268 3.8e-22 73.6 In-house 29-248 (300) alignment 
Range on Protein: 62-268
Range on HMM: 29-248/300.0
YRKLDAKQDPSLTY-DAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNY--LRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKV-
| ..  |.  .|..  .  .  .|||. ||.  ...||.|.  |  . .|| |  .|.     . ..| .||||..|. |||.|....  . |..| .  
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

--GREGRPRYWPSLG---VTETYGCIRV-TNFSESSEEFEICNLAVTFVPDNvpvdEQpanlegLRVSLIKWPNWPDCGVPDE---------KCHTVPQR
  |.|   .|.|.|.    | ..|  .| |.|||.|. .    | . ..| .    |.        |  ... .||| |||..         . . | ..
edgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk....ee......rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

LLAQV----RHGPCVVHCSAGKDRLYVVCL
   .|    .. | .||||||  |  |. |
tnseveskeskPPvlvhCsaGvGrtGvlil
0040438 (Phosphotyrosine protein) phosphatases II 265-331 4.2e-22 74.2 In-house 52-119 (317) alignment 
Range on Protein: 265-331
Range on HMM: 52-119/317.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||. ...  . |||.|.||.. .|. .||. ||||..|. |||||..... ..|. |..
ilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLte
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 81-266 4.3e-22 73.1 In-house 45-186 (392) alignment 
Range on Protein: 81-266
Range on HMM: 45-186/392.0
YMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVgREGRprywpslgvtetygcir
 ..|||| ... .|..||||  || . . ||. | |...     ..|.||||   .. |||||.|||.. .| .. |. .||                  
nlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl.kegd.................

vtnfsesseefeicnlavtfvpdnvpvdeqpaN-LEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHG----PCVVHCSAGKDRLYVV
                                .  .   |.  .. .||| .||   .  .      .. .|    | ..|||||  |  ||
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvv
Y_phosphatase Protein-tyrosine phosphatase 265-331 5.7e-22 73.6 Pfam-A 10-75 (235) alignment 
Range on Protein: 265-331
Range on HMM: 10-75/235.0
VVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|..
ilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmlts
Y_phosphatase Protein-tyrosine phosphatase 265-331 5.7e-22 73.6 In-house 10-75 (235) alignment 
Range on Protein: 265-331
Range on HMM: 10-75/235.0
VVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|..
ilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmlts
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 77-235 1.5e-21 71.5 In-house 29-183 (297) alignment 
Range on Protein: 77-235
Range on HMM: 29-183/297.0
AYTKYMHKNRYCDVVCLDNSRVKLKIDKsRHGDYIHANYVKT--NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPR---YWPSL-G
     ..|||| |..  |..||||.       ||| |.||    .     .|..||||. |. |||......    | ...|.  .|| .   ||||  .
krnsslrknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

VTETYGCIRVTNFSESSEEFEICNLavTFVP--DNvpvdeqpanLEGLRVSLIKWPNWPDCGVPDEK
   . | . |   |. |.||.   |  | .               |   |  ... .||| ||| . 
erlkagdvvveflsstsdefdrvil..telqliyr.........sesrvvrhvqflswpdhGvpsdl
0047943 (Phosphotyrosine protein) phosphatases II 265-331 2.3e-21 71.9 In-house 47-110 (273) alignment 
Range on Protein: 265-331
Range on HMM: 47-110/273.0
VVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||   .. . |||.|.||.. .|  .||. ||||..|. |||||....... |  |..
ilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLte
0045450 (Phosphotyrosine protein) phosphatases II 265-331 2.8e-21 72.0 In-house 64-140 (307) alignment 
Range on Protein: 265-331
Range on HMM: 64-140/307.0
VVCLDNSRVKLKIDKS--RHGDYIHANYV--------KTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|..||||.  ..   ..|||.|.||        .. .|  .||. ||||..|. |||||..... . |. |..
ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmlte
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-155 9.1e-21 68.7 In-house 25-115 (303) alignment 
Range on Protein: 59-155
Range on HMM: 25-115/303.0
VKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKiDKSrhgdYIHANYVKTNYLRSTfICSQGPLQHTIIDFWRMIFQERAESILLLC
|... |. .   ||.. . . | |.|||..||.||| |.|||  | |    ||||.|.. .  . . | .| ||.||  |||.|| ...   .||| 
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls.dss....yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllll
subfamily_CG7180_pd Subfamily CG7180 79-263 1.4e-20 68.1 In-house 40-237 (296) alignment 
Range on Protein: 79-263
Range on HMM: 40-237/296.0
TKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR--PRYWPSLGvTETY
.. . |||. .||  |. || | |.|   . ||| | || .      .|  ..| ..|. .|||....| ....  |.|..   .  | |||  .  | |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqy

GCIRVTNFS-ESSEEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPD-CGVPDE-----KCHTVPQRLLAQV----RHGPCVVHCSAGKDRL
| | |   . ..  ...| .. .|     .   |.. . |   | |...  |.    ||       .     . .  .|     .|| ||..| |. | 
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs
0043147 (Phosphotyrosine protein) phosphatases II 107-262 3.1e-20 68.1 In-house 4-113 (172) alignment 
Range on Protein: 107-262
Range on HMM: 4-113/172.0
HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVgregrprywpslgvtetygcirvtnfsesseefeicnlavtfvpdnvpv
. |||.|.|....|    ||. ||||..|. |||||. ..    |. |..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

dEQPANLEGLRVSLIKWPNWPDCGVPdEKCHTVP-----QRLLAQVRHGPCVVHCSAGKDR
 . .. |.   .  . . .||| |||    .        ..|||. ..||..||||||..|
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgR
0039614 (Phosphotyrosine protein) phosphatases II 265-331 4.2e-20 67.8 In-house 65-134 (297) alignment 
Range on Protein: 265-331
Range on HMM: 65-134/297.0
VVCLDNSRVKLKIDKS--RHGDYIHANYVKTNYL-RSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.||||||  ..   . |||.|.||.. .|   .||..||||..|. |||||..... ..|. |.|
ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtk
0043336 (Phosphotyrosine protein) phosphatases II 265-331 4.5e-20 67.7 In-house 54-121 (278) alignment 
Range on Protein: 265-331
Range on HMM: 54-121/278.0
VVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||. .... . |||.|.||..     .||..||||..|. |||||..... ..|. |..
ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 265-330 1.1e-19 65.3 In-house 57-120 (305) alignment 
Range on Protein: 265-330
Range on HMM: 57-120/305.0
VVCLDNSRVKLkiDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
| |||| ||||  . .   .||||||| |      |||.| ||..|  ||| | .|.. |.|..||
vgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc
0040439 (Phosphotyrosine protein) phosphatases II 265-331 1.9e-19 65.7 In-house 20-87 (249) alignment 
Range on Protein: 265-331
Range on HMM: 20-87/249.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||.| ..  ..|||.|.|... |   .||. ||||..|. |||||..... ..|. |..
ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLts
0045098 (Phosphotyrosine protein) phosphatases II 265-330 3.9e-19 64.6 In-house 42-96 (278) alignment 
Range on Protein: 265-330
Range on HMM: 42-96/278.0
VVCLDNSRVKlkidksrhgDYIHANYVKTNylRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
....|.||||         |||.|.|...   . .||. ||||..|. |||||..... ..|. |.
ilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 264-331 4.6e-19 63.2 In-house 45-114 (281) alignment 
Range on Protein: 264-331
Range on HMM: 45-114/281.0
YVVCLDNSRVKLKI--DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
 . ||| |||.||.   .    |||||||... .|.  .| .||| . |  ||||||.|| . .|..||.
nipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq
0046846 (Phosphotyrosine protein) phosphatases II 106-262 6.9e-19 63.7 In-house 10-122 (176) alignment 
Range on Protein: 106-262
Range on HMM: 10-122/176.0
RHGDYIHANYVKTNYlrstFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSlgvTETYGCirvtnfsesseefeicnlavtfvpd
 . |||.||.. ...    .|. |||| .|. ||..|..... . .. |..    ||   |.|||     |..|.                         
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.........................

nvpvdeqpanleglrvsLIKWPNWPDCGVPDEK--CHTVPQRLLAQVRHGPCVVHCSAGKDR
                  ... .||| |||| .  .. . .   |. ..|| .||||||. |
.................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigR
0036282 (Phosphotyrosine protein) phosphatases II 108-267 7.7e-19 63.5 In-house 2-122 (174) alignment 
Range on Protein: 108-267
Range on HMM: 2-122/174.0
GDYIHANYVKTNYLRSTFICSQGPLQhtiidFWRMIFQERAESILLLCKVGR---EGRPRYWPSlgvtetygcirvtnfsesseefeicnlavtfvpdnv
 |||.|.... .|  . .|..||||.     ||.|..... .... |..      .. ..|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

pvdeqPANLEGLRVSLIKWPNWPDCGVPDE----KCHTVPQRLLAQVRHGPCVVHCSAGKDRLYVVC
       . .   .  ... .||| ||||     ..    .. |.. ..||..||||||..|  ...
.....lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlv
subfamily_PTPRD_pd Subfamily PTPRD 265-330 8e-19 62.7 In-house 57-123 (564) alignment 
Range on Protein: 265-330
Range on HMM: 57-123/564.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.|  |.|||.| |...    ||| |.....   | ..| .||||..|| |||||..... ..| .| 
ivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt
subfamily_egg_pd Subfamily egg 264-329 1e-18 62.1 In-house 48-114 (307) alignment 
Range on Protein: 264-329
Range on HMM: 48-114/307.0
YVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
 | | | |||||.. . .. .|.||||.|| . |  .||..| ||. |  |||||.|||. . |..|
rvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 82-262 2.6e-18 60.8 In-house 51-227 (301) alignment 
Range on Protein: 82-262
Range on HMM: 51-227/301.0
MHKNRYCDVVCLDNSRVKLKIDKSRHGdyIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSLGvTETYGCIRVT
 .|.||  | |  .. |..  |  |    ||||...|.     ||..||||. |  ||| |. |   | | .|..   .   .    |  ...   ... 
kdkhryptvPckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylp.vkisekldig

NFSESSEEFEICnLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKDR
 |.   .. |   |    .  .. | .   ...   |   .. .|.| |||  . ..     |..  . | |||||||  |
rfkikiknkeli.lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGr
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 265-330 5e-18 59.8 In-house 65-126 (290) alignment 
Range on Protein: 265-330
Range on HMM: 65-126/290.0
VVCLDNSRVKLKidKSRHGDYIHANYVKTnyLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
||| | .|| ||     .|||.||||||   |...|| .||.|. |.||.|||. ||..  | .||
vvcndktrvilk..dGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlc
subfamily_PTPRN_pd Subfamily PTPRN 75-266 6.3e-18 59.5 In-house 50-241 (297) alignment 
Range on Protein: 75-266
Range on HMM: 50-241/297.0
YDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLR-STFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG---RPRYWPSL
     |...|||. .|.  |.|||||| . |. . ||| |  .  .  | ...| .|||| .|. |||.|.... .  |. |...  ||     ||||  
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

GvTETYGCIRVTNFSES--SEEFeicnLAVTFVPDNVPVDeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTVPQRL-LA---QVRHGPCVVHCSAGKDRL
| .|.|.   |   ||   ....    |  .|   |.  .      |   |.  ..  ||. ||| .    .  |  .    . |  | |||||.|  | 
G.sevyhiyevhlvsehiwcddy....lvrsfylknlqts......etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrt

YVV
 | 
Gvy
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 83-262 6.5e-18 59.8 In-house 10-187 (239) alignment 
Range on Protein: 83-262
Range on HMM: 10-187/239.0
HKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWPSlgVTETYGC
 ||||...|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|  .    ..   .|||    |  |  
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stskycn

IRVTNfsESSEEFeICNLAVTFVPDNVpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGKDR
.|||     .| |    .  |||  .|       . |   |   ..  ||| |||.     .  |  .  .      | |.|||||  |
lrvtl..rktevf.adyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 83-262 7.6e-18 59.5 In-house 9-186 (239) alignment 
Range on Protein: 83-262
Range on HMM: 9-186/239.0
HKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWPSlgVTETYGC
 ||||...|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|  .    ..   .|||    |  |  
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stskycn

IRVTNfsESSEEFeICNLAVTFVPDNVpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGKDR
.|||     .| |    .  |||  .|       . |   |   ..  ||| |||.     .  |  .  .      | |.|||||  |
lrvtl..rktevf.adyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr
subfamily_PTPRB_pd Subfamily PTPRB 265-330 7.9e-18 59.5 In-house 60-126 (293) alignment 
Range on Protein: 265-330
Range on HMM: 60-126/293.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
..  |.||||| ....... ||| |||.. .  .  || .|||| .|. |||||....... |..| 
ilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmlt
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 265-331 8.1e-18 59.5 In-house 50-115 (307) alignment 
Range on Protein: 265-331
Range on HMM: 50-115/307.0
VVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
| | |..|. .|.|     |||||||. .      |||.||||. |. .|| |. ||. ||...|||
vkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck
0042113 (Phosphotyrosine protein) phosphatases II 265-331 1.2e-17 59.7 In-house 18-85 (245) alignment 
Range on Protein: 265-331
Range on HMM: 18-85/245.0
VVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|..||||. |... . |||.|.||.. .   .||..||||..|. |||||..... ..|. |..
ilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLte
subfamily_PTPN12_pd Subfamily PTPN12 265-331 2.1e-17 57.9 In-house 49-116 (290) alignment 
Range on Protein: 265-331
Range on HMM: 49-116/290.0
VVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
..  |.|||.|. ... .  ||| ||..|  . . ..| .|||| .|. ||||||.. . | ....|.
ilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 266-331 4.5e-17 57.2 In-house 56-122 (305) alignment 
Range on Protein: 266-331
Range on HMM: 56-122/305.0
VCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
. ||..|..|. ..| .  ||| |.||..   . ..| .||||..|. ||||.|..|. ..|..|.|
tlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 265-329 5.9e-17 56.7 In-house 18-83 (250) alignment 
Range on Protein: 265-329
Range on HMM: 18-83/250.0
VVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.. ||.||| |. .|  .. ||| | ....   |..|| .|||||.|| |||||...| ...|..|
iialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmL
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 265-331 9.7e-17 55.5 In-house 64-129 (305) alignment 
Range on Protein: 265-331
Range on HMM: 64-129/305.0
VVCLDNSRVKlkIDKSRHGDYIHANYVKTNYLR-STFICSQGPLQHTIIDFWRMIFQERAESILLLCK
| | |.| ||  .||    ||||||||    .    |||.||||..|| .|| |. |.. | |..|||
vpcqdqsavk..ldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlck
subfamily_PTPN9_pd Subfamily PTPN9 265-329 1.2e-16 55.6 In-house 51-116 (297) alignment 
Range on Protein: 265-329
Range on HMM: 51-116/297.0
VVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|.|.|..||.|. .|.  . |||.||.|     . .||  ||||..|. |||||......  |.. 
vlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 265-329 1.4e-16 55.7 In-house 65-130 (298) alignment 
Range on Protein: 265-329
Range on HMM: 65-130/298.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.. || ||| |.  |.  ..||| | ....   |..|| .|.||..|. |||||. .| ...| .|
iialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVml
0051082 (Phosphotyrosine protein) phosphatases II 108-262 3.8e-16 54.5 In-house 3-105 (151) alignment 
Range on Protein: 108-262
Range on HMM: 3-105/151.0
GDYIHANYVKTNylrstFICSQGPLQhtiiDFWRMIFQERAESILLLCKVG-REGRPRYWPSLGvtetygcirvtnfsesseefeicnlavtfvpdnvpv
 |||...||  .     ...|.|||.    ||.... ..   .|. |..   |.  |.|.|.||                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

deqpanlegLRVSLIKWPNWPDCGVPD--EKCHTVPQRLLAqVRHGPCVVHCSAGKDR
         ..|  | ...||| |.|.  . .  . . ||.  ..||..|||||||.|
.........ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgR
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 265-330 5e-16 53.6 In-house 55-121 (318) alignment 
Range on Protein: 265-330
Range on HMM: 55-121/318.0
VVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
..  |..||||.  . .   ||| |||.  .  . ..| .|.|| .|| |||||...  .  |..| 
ilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 81-205 7e-16 52.9 In-house 47-187 (350) alignment 
Range on Protein: 81-205
Range on HMM: 47-187/350.0
YMHKNRYCDVVCLDNSRVKLK--------IDKSR-HGDYIHANYVKTN----YLRSTF--ICSQGPLQHTIIDFWRMIFQERAESILLLCK---VGREGR
 . |||| ...  . ||||||        ...|    ||| |||.| .       . |  |  |.||. |. ||...|..   . || | .    ..|  
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

PRYWPSLGVTETygCIRVTNFSESSEEFEICNLAVTFVPDNVP
 |||. ... .    .....  |.  . . . | .. |  . .
yrYWqegsyddi..tvklaskwenimgindsslysadvkkeas
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 265-329 7.1e-16 53.1 In-house 56-121 (288) alignment 
Range on Protein: 265-329
Range on HMM: 56-121/288.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.. .|  |||||  .. .  ||| |.|.. .  . ..|..||||..|. |||......... |. |
ilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 268-330 8.9e-16 52.8 In-house 40-105 (274) alignment 
Range on Protein: 268-330
Range on HMM: 40-105/274.0
LDNSRVKLKIDKSRH--GDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 .|||| |. ..|..   .|| |||.|  ..   ...  ||||..|. ||||||.||... |..| 
nensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt
0049260 (Phosphotyrosine protein) phosphatases II 118-262 9.2e-16 53.4 In-house 4-102 (152) alignment 
Range on Protein: 118-262
Range on HMM: 4-102/152.0
TNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWpslgvtetygcirvtnfsesseefeicnlavtfvpdnvpvdeqpanle
  .    ||. |||. .|. |||||. .  .  |. |..     ... ..|.                                                
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................

glrvsLIKWPNWPDCGVPDEKCHTVPQRLL----AQVRHGPCVVHCSAGKDR
      ... .||| ||||   .     |.    |. ..||..||||||..|
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgR
subfamily_PTPRG_pd Subfamily PTPRG 264-329 1.6e-15 51.3 In-house 55-122 (563) alignment 
Range on Protein: 264-329
Range on HMM: 55-122/563.0
YVVCLDNSRVKLKIDKSRHG--DYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
 .|  |.|||||.     ..  ||| |||..  .    || .||||..|. ||||||...... | ..
nivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmi
subfamily_Ptp69D_pd Subfamily Ptp69D 266-329 1.7e-15 52.0 In-house 58-122 (307) alignment 
Range on Protein: 266-329
Range on HMM: 58-122/307.0
VCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.  |. ||||| |  . . ||| |...|.   . .||..|.|.. || |||||| .   . | .|
kafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml
subfamily_PTPRK_pd Subfamily PTPRK 265-329 2.1e-15 51.4 In-house 52-117 (314) alignment 
Range on Protein: 265-329
Range on HMM: 52-117/314.0
VVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
..  |.|||.|. ||   . ||| |... .    . ||  |||||.|. ||||....|.. ||..|
ilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivml
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 80-199 2.3e-15 51.3 In-house 32-150 (267) alignment 
Range on Protein: 80-199
Range on HMM: 32-150/267.0
KYMHKNRYCDVVCLDNSRVKLKIDKSRhgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSL-GVTETYGCI
|   .||. |..  |..|| |.  .     || | ||.. . . .||  |.||. || ||. .| ...   | || ||. .  ...||   | .. |  .
knqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdl

RVTNFSESSE-EFEICNLAVTF
 |    |  | ...|  | . |
tvehslekeendyqiitlelkf
subfamily_PTPN6_pd Subfamily PTPN6 265-328 2.4e-15 51.3 In-house 63-128 (306) alignment 
Range on Protein: 265-328
Range on HMM: 63-128/306.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNYL--RSTFICSQGPLQHTIIDFWRMIFQERAESILL
..  |..||.|| ..    ||| |||.|..    . ..| .|| |..|. |||||..|| .. |..
ilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 260-331 4.4e-15 50.5 In-house 51-124 (319) alignment 
Range on Protein: 260-331
Range on HMM: 51-124/319.0
KDRLY-VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
|.|   ..  |..||.| ..| .   ||| |... .   |. ||  |.||..|| |||||...|..  ...|.|
knryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk
0037934 (Phosphotyrosine protein) phosphatases II 265-331 5.8e-15 51.0 In-house 19-81 (243) alignment 
Range on Protein: 265-331
Range on HMM: 19-81/243.0
VVCLDNSRVKLkidksRHGDYIHANYVKTNylrSTFICSQGPLQHTIID----FWRMIFQERAESILLLCK
....|.|||||       .|||.||...      ..|..||||..|. |    ||||..... ..|. |..
ilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmlte
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 265-329 7.7e-15 49.7 In-house 50-115 (281) alignment 
Range on Protein: 265-329
Range on HMM: 50-115/281.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|  |..|||. . ... . ||| ||.|..      .| .|||. ... .||.|....... | ..
ivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv
subfamily_ptpA1_pd Subfamily ptpA1 265-330 1.1e-14 49.0 In-house 56-121 (418) alignment 
Range on Protein: 265-330
Range on HMM: 56-121/418.0
VVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRsTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.. .. .||.|| |.     ||| |||.   | .  |||.||||  || |||||....|.  |..| 
ilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmls
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 264-330 1.7e-14 49.0 In-house 33-100 (284) alignment 
Range on Protein: 264-330
Range on HMM: 33-100/284.0
YVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 ..  |...|||. ..     ||| | ...    .  .| .||||. |. ||||||.. .. .|.|| 
hilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 264-330 1.7e-14 48.9 In-house 69-136 (319) alignment 
Range on Protein: 264-330
Range on HMM: 69-136/319.0
YVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 ..  |...|||. ..     ||| | .|.    .  .| .||||. |. ||||||.. .. .|.|| 
nilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 267-330 1.9e-14 48.2 In-house 55-119 (315) alignment 
Range on Protein: 267-330
Range on HMM: 55-119/315.0
CLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 ||..||||  ||.| . ||| | |.|.     ..|.|||||. .. |||||..||.. .| .. 
PldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt
subfamily_CG42327_pd Subfamily CG42327 83-236 2.1e-14 47.9 In-house 30-181 (319) alignment 
Range on Protein: 83-236
Range on HMM: 30-181/319.0
HKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG---RPRYWPS---LGVTET
 |.|. .|| | ..|| |. | .  .  |..|.||.     .. .|..| .|. .  ||||.... ..  |. |...   |    ..|.|.   |  |..
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YGCIRVTN-FSESSEEFEICNLAVTfvpdNVPVDEQpanleglRVSLIKWPNWPDCGVPDEKC
|| |.||    |. ... |  | .     .|  .|        |     | .|....|| |. 
yGdilvtlkgrevkdryaistlllk....rvdkees.......relthywykwleaevPaeea
subfamily_PTPRA_pd Subfamily PTPRA 265-330 3.6e-14 47.4 In-house 67-133 (330) alignment 
Range on Protein: 265-330
Range on HMM: 67-133/330.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
..  | ||| |   .   . ||| | ...    . .|| .|||...|. ||||||.. .. .|..| 
ilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 265-331 3.7e-14 47.4 In-house 56-119 (287) alignment 
Range on Protein: 265-331
Range on HMM: 56-119/287.0
VVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
..  || || ||    .| ||| | ....   .  || ...|. .|. .||..| ... . |..||.
ilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcq
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 265-329 5e-14 46.7 In-house 47-111 (287) alignment 
Range on Protein: 265-329
Range on HMM: 47-111/287.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|. .|..|| |  .     ||| |||| .     .||..|||.  |. ||||.....|. |....
vlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 266-330 5.8e-14 46.3 In-house 55-120 (392) alignment 
Range on Protein: 266-330
Range on HMM: 55-120/392.0
VCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
. .|..||||  || . . ||. | |...     ..|.||||   .. |||||.|||.. .| .. 
lpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 267-330 6e-14 46.0 In-house 54-118 (515) alignment 
Range on Protein: 267-330
Range on HMM: 54-118/515.0
CLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 .|..||||  |. . | ||. | |...     ..|.||||.. .. ||||...||.   | .. 
PydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 265-331 6.4e-14 46.5 In-house 55-124 (290) alignment 
Range on Protein: 265-331
Range on HMM: 55-124/290.0
VVCLDNSRVKLKiDKSRHGD----YIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.|  |. |. |. ..| | |    ||.| |.|    .  .|  |||...|..|||..| ||.   |..|..
ivvyddnritLr.pisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltn
subfamily_PTPN23_pd Subfamily PTPN23 266-330 7.7e-14 46.2 In-house 53-115 (288) alignment 
Range on Protein: 266-330
Range on HMM: 53-115/288.0
VCLDNSRVKLKidkSRHGDYIHANYVKTNYLRS-TFICSQGPLQHTIIDFWRMIFQERAESILLLC
.  |..||||.   . . ||| | .||     . .||..|.||| |. |||.|....... | .| 
lPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 265-329 1e-13 46.2 In-house 57-122 (325) alignment 
Range on Protein: 265-329
Range on HMM: 57-122/325.0
VVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|| ||.||| |.  | . . ||| |.|....  . .|. .| || .|| |.||.... |.  ...|
vvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 265-331 1.3e-13 45.5 In-house 42-108 (283) alignment 
Range on Protein: 265-331
Range on HMM: 42-108/283.0
VVCLDNSRVKLKIDKSrhgDYIHANYVK--TNY-LRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.|  |. ||.|| .     ||| | ..    .|     .| .|.||..|..|||.|.|.|.. .|..| |
ivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 279-330 1.3e-13 45.4 In-house 66-117 (301) alignment 
Range on Protein: 279-330
Range on HMM: 66-117/301.0
KSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.. . .|| |.|..    .  || .|||...|..||||.|.||.  ||. ..
dlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 265-329 2e-13 45.0 In-house 58-123 (315) alignment 
Range on Protein: 265-329
Range on HMM: 58-123/315.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
..  |.|||.|  ...  | ||. ||...    .  .|..|||.  .. ||||..|.|    |..|
iiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 265-330 3.6e-13 44.1 In-house 44-107 (285) alignment 
Range on Protein: 265-330
Range on HMM: 44-107/285.0
VVCLDNSRVKLKidkSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
| |....|| ||    .  |||||....     .||.| .||||  |. |||.||.||.   .|.||
vrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlc
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 268-329 5.1e-13 43.8 In-house 63-123 (297) alignment 
Range on Protein: 268-329
Range on HMM: 63-123/297.0
LDNSRVKLKIDKSR-HGDYIHANYVKTNYLrsTFICSQGPLQHTIIDFWRMIFQERAESILLL
 | |||||.|  .    ||. | .||.|     .|..| | . |. |||.|...|..  |..|
ydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 270-329 5.9e-13 43.4 In-house 34-95 (270) alignment 
Range on Protein: 270-329
Range on HMM: 34-95/270.0
NSRVKL-KIDKSRHGDYIHANYVK-TNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
..||.| ....  .  || ||||.  .  . ..|...|||. |. .|||||..|....|...
atRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt
subfamily_PTPN1_pd Subfamily PTPN1 266-330 6.7e-13 43.0 In-house 42-103 (290) alignment 
Range on Protein: 266-330
Range on HMM: 42-103/290.0
VCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
   | ||.||. ..    ||| |. |. . ..  .| .|||| .|.  ||.|...... ....| 
spydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmln
subfamily_PTPN3_pd Subfamily PTPN3 266-329 7.1e-13 43.1 In-house 51-115 (280) alignment 
Range on Protein: 266-329
Range on HMM: 51-115/280.0
VCLDNSRVKLKidKSRHgDYIHANYVKTNYLR----STFICSQGPLQHTIIDFWRMIFQERAESILLL
.  |. |||||  .|.  ||| ||||. .         .| .||||..|  |||.|....... |..|
lpydatrvklk..eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 264-329 1.8e-12 41.5 In-house 55-114 (303) alignment 
Range on Protein: 264-329
Range on HMM: 55-114/303.0
YVVCLDNSRVKLKiDKSrhgdYIHANYVKTNYLRSTfICSQGPLQHTIIDFWRMIFQERAESILLL
 |.||| |.|||  | |    ||||.|.. .  . . | .| ||.||  |||.|| ...   .|||
dvicldhskvkls.dss....yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlll
0044763 (Phosphotyrosine protein) phosphatases II 106-262 3.9e-12 41.7 In-house 16-123 (178) alignment 
Range on Protein: 106-262
Range on HMM: 16-123/178.0
RHGDYIHANYVKTNylrsTFICSQGPlqhtiIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVtetygcirvtnfsesseefeicnlavtfvpd
  .|||.|...  .     ...|..|      |..... ..   .|. |..  . |.   ..|||.                                  
ersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

nvpvdeqpanleglrvSLIKWPNWPDCGVPDEKCHTVPQRLLA---Q-VRHGPCVVHCSAGKDR
                   .. ..|| ||||   |.     .    .  ..||..||||||..|
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgR
0041856 (Phosphotyrosine protein) phosphatases II 276-330 8.4e-12 40.5 In-house 12-66 (182) alignment 
Range on Protein: 276-330
Range on HMM: 12-66/182.0
KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 .| ||. |||.||..  ..  ..||. ||||..|. ||.||. ...  .|. |.
pydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 265-331 1.3e-11 39.1 In-house 52-115 (288) alignment 
Range on Protein: 265-331
Range on HMM: 52-115/288.0
VVCLDNSRVKLKiDKSRHgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
. . | .||||. | .    ||.|| | ..  .  .||.| ||. ||  .|.|....  | |..||.
lprcditrvkls.ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce
0049772 (Phosphotyrosine protein) phosphatases II 265-320 1.7e-11 39.9 In-house 55-116 (314) alignment 
Range on Protein: 265-320
Range on HMM: 55-116/314.0
VVCLDnSRVKLKIDKSRHGDYIHANYVKTNylrSTFICSQGPLQHTIIDF----------WRMIFQ
... | .||.|.    .  |||.|.||..     .||..||||..|..||          |||...
ilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr
subfamily_CG7180_pd Subfamily CG7180 265-331 2e-11 38.1 In-house 51-118 (296) alignment 
Range on Protein: 265-331
Range on HMM: 51-118/296.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
||  |. || | |.|   . ||| | || .      .|  ..| ..|. .|||....| ....  |.|
vvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 82-261 2.4e-11 38.3 In-house 19-203 (290) alignment 
Range on Protein: 82-261
Range on HMM: 19-203/290.0
MHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKT-NYLRstFICSQGPLQHT-------IIDFWRMIFQERAESILLLCKVGREGRP-------RY
 ....  .|  . ..|| ||  ..|   ||||||.|.  | ||  .| .| |....       | .|| |. ||.....  ||..  . .        .|
hemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPS-LGVTETYGCIRVTNF-SESSEEFEICNLAVTFvpdnvpvD-EQPanlegLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKD
 |   |   ... . |     |  ...|. .| |.|       | |..     . |   .  .| .. |....   .      . .. | .|||  |  
vpesvgeelkfkgltvkCkskekeddvetRelvvkf.......ddeee.....ftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiS
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 67-176 3.1e-11 37.3 In-house 81-188 (244) alignment 
Range on Protein: 67-176
Range on HMM: 81-188/244.0
AKQDPSLTYDAYTK-YMHKNRYCDVVCLDNSRVKLKiDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGrpRY
 . |||.  ||.     .|||    . .| .|| |    |    || | .|      . .| .| ||  | .|||.|...   . ...|  |  |    |
irpdpsvmkdafnpnnswknregaglpfdfnrvpls.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed..ey

WPSLGVTETYG
||     | | 
wpdseplewye
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 73-156 3.9e-11 37.0 In-house 26-109 (332) alignment 
Range on Protein: 73-156
Range on HMM: 26-109/332.0
LTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPL-QHTIIDFWRMIFQERAESILLLCK
 ||| . . |  ||   . |.| |||.|  .   . |.  |..|     .|..| .| |. .||   ||||. . .   ||..  
ntydkflnnmdmnriphlycfdhsrvelapqdg.kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 53-182 5.1e-11 36.5 In-house 23-155 (302) alignment 
Range on Protein: 53-182
Range on HMM: 23-155/302.0
LGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKsrhGDYIHANYVKTNYLRSTFICSQGPLQHTI---IDFWRMIFQERAE
|    . |.. |.|. . .     |. | ..||.  || .||. .|||.  .    .|..|  |.   |. . | .| | . .     .||||.|||.  
ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

SILLLCKVGREGR--PRYWP-SLGVTETYGCIRVTN
|. .| .     .    ..|   |  ..|| ..| |
svvilvgeeelkktlselfpkksgdykeygkmfvNn
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 265-330 5.1e-11 36.7 In-house 57-123 (439) alignment 
Range on Protein: 265-330
Range on HMM: 57-123/439.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
|. .| .|| | .|    |  || |||.|  |    .| .||| ..|  ||||.......  |. |.
vgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 265-329 7.3e-11 36.7 In-house 12-76 (237) alignment 
Range on Protein: 265-329
Range on HMM: 12-76/237.0
VVCLDNSRVKLKIDKSRhGDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|. | ||| ||   |   ||| |.|.|  .    ..|..||||. .  |||.|..||.   |..|
ivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivml
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 270-331 8.5e-11 36.1 In-house 64-123 (301) alignment 
Range on Protein: 270-331
Range on HMM: 64-123/301.0
NSRVKLKIDKSRHgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.. |..  |  |    ||||...|.     ||..||||. |  ||| |. |   | | .|..
stavevivdGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgq
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 266-329 1.4e-10 35.5 In-house 43-107 (297) alignment 
Range on Protein: 266-329
Range on HMM: 43-107/297.0
VCLDNSRVKLKIDKsRHGDYIHANYVKT--NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.  |..||||.       ||| |.||    .     .|..||||. |. |||......    | ..
latddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv
subfamily_PTPN14_pd Subfamily PTPN14 265-329 2e-10 35.2 In-house 58-124 (300) alignment 
Range on Protein: 265-329
Range on HMM: 58-124/300.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNY--LRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|.  ...||.|.  |  . .|| |  .|.     . ..| .||||..|. |||.|....  . |..|
vlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml
0043147 (Phosphotyrosine protein) phosphatases II 282-331 3e-10 35.6 In-house 4-53 (172) alignment 
Range on Protein: 282-331
Range on HMM: 4-53/172.0
HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
. |||.|.|....|    ||. ||||..|. |||||. ..    |. |..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnlte
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 67-150 3.3e-10 34.0 In-house 23-112 (347) alignment 
Range on Protein: 67-150
Range on HMM: 23-112/347.0
AKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHG------DYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAES
.   . .|.  . | . |||  ||   |..|| |  .||. .       || | ..| .  .  .| .| || .|. |||.|..  .   
nyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 260-330 6.8e-10 33.6 In-house 22-99 (290) alignment 
Range on Protein: 260-330
Range on HMM: 22-99/290.0
KDRLYVVCLDNSRVKLKIDKSRH-GDYIHANYVKT-NYLRstFICSQGPLQHT-------IIDFWRMIFQERAESILLLC
. || |  . ..|| ||  ..|   ||||||.|.  | ||  .| .| |....       | .|| |. ||.....  ||
dqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlc
subfamily_PTPN13_pd Subfamily PTPN13 265-329 7.8e-10 33.5 In-house 46-108 (273) alignment 
Range on Protein: 265-329
Range on HMM: 46-108/273.0
VVCLDNSRVKLKIDKSrhgdYIHANYVKTNYLRST--FICSQGPLQHTIIDFWRMIFQERAESILLL
|.  |..||||. . .    || |...| .    .  .| .|||| .|. |||.|... .|| | ..
vlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 265-330 1.5e-09 32.0 In-house 52-114 (312) alignment 
Range on Protein: 265-330
Range on HMM: 52-114/312.0
VVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
. | |  |  |  |.     |||||.||       |.|.||||. |.  ||.. .   . ||.|||
iqcwdrgrftlagden...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 265-329 1.7e-09 32.2 In-house 17-83 (239) alignment 
Range on Protein: 265-329
Range on HMM: 17-83/239.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|
ivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 265-329 1.7e-09 32.2 In-house 16-82 (239) alignment 
Range on Protein: 265-329
Range on HMM: 16-82/239.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|
ivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml
subfamily_PTPRN_pd Subfamily PTPRN 261-330 2e-09 31.6 In-house 60-132 (297) alignment 
Range on Protein: 261-330
Range on HMM: 60-132/297.0
DR-LYVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLR-STFICSQGPLQHTIIDFWRMIFQERAESILLLC
.|   |.  |.|||||| . |. . ||| |  .  .  | ...| .|||| .|. |||.|.... .  |. |.
nrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 264-330 2.4e-09 31.6 In-house 41-104 (267) alignment 
Range on Protein: 264-330
Range on HMM: 41-104/267.0
YVVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
...  |..|| |.    .  .|| | ||.. . . .||  |.||. || ||. .| ...   | || 
dnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 82-205 1.4e-08 28.4 In-house 49-190 (349) alignment 
Range on Protein: 82-205
Range on HMM: 49-190/349.0
MHKNRYCDVVCLDNSRVKLKID---------------KSRHGDYIHANYVKTNYLR--STFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR--
. |||| |..  . ||||||                  ..  ||| |||.|   .     .|. | ||  |. ||...|  .. . .| | .   ..   
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

-PRYWPSLGVTETygCIRVTNFSESSEEFEICNLAVTFVPDNVP
  .||  |  ..    ... | |. . . . . | |  | |. .
cdiywqelsysni..tvklqnsslyianvqGnslrvstvkdtdn
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 270-329 2.8e-08 27.9 In-house 61-135 (350) alignment 
Range on Protein: 270-329
Range on HMM: 61-135/350.0
NSRVKLK--------IDKS-RHGDYIHANYVKTN----YLRSTF--ICSQGPLQHTIIDFWRMIFQERAESILLL
 ||||||        ...| .  ||| |||.| .       . |  |  |.||. |. ||...|..   . || |
hsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl
0046846 (Phosphotyrosine protein) phosphatases II 280-330 6.2e-08 28.1 In-house 9-55 (176) alignment 
Range on Protein: 280-330
Range on HMM: 9-55/176.0
SRHGDYIHANYVKTNYlrstFICSQGPLQHTIIDFWRMIFQERAESILLLC
  . |||.||.. ...    .|. |||| .|. ||..|..... . .. |.
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlt
0051429 (Phosphotyrosine protein) phosphatases II 283-330 8.2e-08 27.7 In-house 4-53 (272) alignment 
Range on Protein: 283-330
Range on HMM: 4-53/272.0
GDYIHANYVKTNYL---RSTFICSQGPLQHTIIDFWRMiFQERAESILLLC
..||.|..|....    . ....|.|||..|. ||||.  ...  .|. |.
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLr
PTPc_DSPc_SM00012 218-267 8.8e-08 27.7 In-house 2-57 (105) alignment 
Range on Protein: 218-267
Range on HMM: 2-57/105.0
VSLIKWPNWPDCGVPDEKchTVPQRLLAQVRH--------GPCVVHCSAGKDRLYVVC
|. .....|||.|||.|   .   .||..|..        .|.||||||| .|  ...
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfv
0036282 (Phosphotyrosine protein) phosphatases II 283-331 1.4e-07 26.9 In-house 2-45 (174) alignment 
Range on Protein: 283-331
Range on HMM: 2-45/174.0
GDYIHANYVKTNYLRSTFICSQGPLQhtiidFWRMIFQERAESILLLCK
 |||.|.... .|  . .|..||||.     ||.|..... .... |..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 123-182 2.1e-07 24.6 In-house 236-295 (440) alignment 
Range on Protein: 123-182
Range on HMM: 236-295/440.0
STFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSLGVTETYGCIRVTN
 .||..| ||. |..||||.. . |  .|..| ..       |||    . |.| . |  
nafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvgh
0048179 (Phosphotyrosine protein) phosphatases II 186-262 2.6e-07 26.0 In-house 19-96 (144) alignment 
Range on Protein: 186-262
Range on HMM: 19-96/144.0
SSEEFEICNLAVTFVPDNVPvdEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQ-----RLLAqvRHGPCVVHCSAGKDR
...  ....| .| | . ..  | . . ..  .  . . .||| ||||   .         ..|.  ..||..||||||..|
aldlellkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgR
0048076 (Phosphotyrosine protein) phosphatases II 181-262 3.3e-07 25.6 In-house 14-94 (145) alignment 
Range on Protein: 181-262
Range on HMM: 14-94/145.0
TNFSESSEEFEICNLAVTFVPDNvPVDEQPANlegLRVSLIKWPNWPDCGVPDE--KCHTVPQRLLAQV-RHGPCVVHCSAGKDR
 ..   ..  ....| .| | .    ...        .  . . .|||.||||      .. . . . . ..||..||||||..|
gslptaldlellkdlgittvlnl.tselelle...rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgR
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 102-192 5.7e-07 23.9 In-house 7-94 (130) alignment 
Range on Protein: 102-192
Range on HMM: 7-94/130.0
IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREgrPRYWPSLGVTETYGCiRVTNFSESSEEFEI
... .  .||.|..|      . .. .| ||  | .|||.|...   . ...|  |  |    |||     | |   ...  .   .||. 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..deywpdsePlewyee.diivtltdrdefkn
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 264-328 9.7e-07 22.6 In-house 42-105 (332) alignment 
Range on Protein: 264-328
Range on HMM: 42-105/332.0
YVVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPL-QHTIIDFWRMIFqERAESILL
.. |.| |||.|  .   . |.  |..|     .|..| .| |. .||   ||||.  ||  |..|
hlycfdhsrvelapqdg.kddfynaswvdgyskksayifaqapfndhteyvfwrmvs.erkpsmil
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 266-329 1.6e-06 21.7 In-house 61-124 (302) alignment 
Range on Protein: 266-329
Range on HMM: 61-124/302.0
VCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTI---IDFWRMIFQERAESILLL
 .||. .|||.    .  .|..|  |.   |. . | .| | . .     .||||.|||.  |. .|
pildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil
subfamily_CG42327_pd Subfamily CG42327 271-330 2.1e-06 21.7 In-house 43-104 (319) alignment 
Range on Protein: 271-330
Range on HMM: 43-104/319.0
SRV-KLKIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.||   .| .  .  |..|.||.     .. .|..| .|. .  ||||.... ..  |. |.
trvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 279-329 2.2e-06 21.2 In-house 86-138 (349) alignment 
Range on Protein: 279-329
Range on HMM: 86-138/349.0
KSRHGDYIHANYVKTNYLR--STFICSQGPLQHTIIDFWRMIFQERAESILLL
 ..  ||| |||.|   .     .|. | ||  |. ||...|  .. . .| |
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL
subfamily_eak_pd Subfamily eak 63-181 2.3e-06 21.3 In-house 33-155 (332) alignment 
Range on Protein: 63-181
Range on HMM: 33-155/332.0
RKLDAKQD-PSLTYDAYTKYMHKNrYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK---VG
 .|| .|   | .  | .. ...|   ..|  |   |.|   .  .  || |  .. . .   .| .  . .  .  ||.|...... .|. | .    .
adlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

REGRPRYWPSLG-VTETYGCIRVT
 |   .|.|  .     .| . |.
leksdkyfpdktreelkfGildve
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 269-323 3.2e-06 20.9 In-house 50-110 (347) alignment 
Range on Protein: 269-323
Range on HMM: 50-110/347.0
DNSRVKLKIDKSRH------GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
|..|| |  .||.         || | ..| .  .  .| .| || .|. |||.|..  . 
datrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv