Gene Y39A3A.4 in Caenorhabditis elegans

Synonym: CELE_Y39A3A.4, CELE_Y39A3A.4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf14
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP213_AA protein Get Run
CeleP213_AA_40-329 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 32-267 9.8e-169 554.7 In-house 3-241 (310) alignment
Range on Protein: 32-267
Range on HMM: 3-241/310.0
TEEDHLQYLKALENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGP
|.. ||.|||||||||..||||||.||||||||||||||.||||.||.||||||||.||||||.|||||||||||..|||||||||||||||||||||||
tddhhlkylkalenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgp

LQHTIIDFWRMIFQERAESILLLCKVGREGRPR---YWPSLGVTETYGCIRVTNFSESSEEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPD
|||||||||||||||||||||||||||.||||.   ||||||||||||||||||.||||||||||||||||||||||||||||||..|||||||||||||
lqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpd

CGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKDRLYVVC
.|||||||||||||||||||||||||||||||||||||.
rgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvv

0051299 (Phosphotyrosine protein) phosphatases II 42-267 3.1e-49 163.3 In-house 9-237 (288) alignment
Range on Protein: 42-267
Range on HMM: 9-237/288.0
ALENFIFSTEKLGIDGLVKQYRKLDAKQ-DPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDF
 |....  . . |. || .....| ... |..|.. .. ....|||| |....|.|||||.  ..  ..|||.|.|... .|  .||. ||||..|. ||
ellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedF

WRMIFQERAESILLLCKVGREG---RPRYWPSlGVTETYGCIRVTNFSESSeefeiCNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKC
|||..... . |  |.|.   |    ..|||. | ..||| |.||. || .     ..  ....   ...|    . | ..|  . ..|||| ||||   
WrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

HTVPQRLLAQVR----HGPCVVHCSAGKDRLYVVC
. .    |..      .||.|||||||..|  ...
llldflrlvrkalasgggpvvVHCsaGvgRtgtfi

0040438 (Phosphotyrosine protein) phosphatases II 43-262 1.3e-48 161.3 In-house 5-222 (317) alignment
Range on Protein: 43-262
Range on HMM: 5-222/317.0
LENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|.....   |..  .| .....|.  . .. .. .. . ..|||| |....|.|||||. ...  . |||.|.||.. .|. .||. ||||..|. ||||
lllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwr

MIFQERAESILLLCKVGREG---RPRYWPSlGVTETYGCIRVTNFSES-SEEFEICNLAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDekCH
|..... ..|. |..    |     .|||. | | ||| ..||. ||   ..... .| |.   |.          | ..|  . ...||| |||.   .
mvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgds..........esrtvthfhytgWpdhgvpp..sp

TVPQRLLAQVR------HGPCVVHCSAGKDR
.  ...| .||      .||..||||||..|
dllldfleavrealedpggpvlVHCsaGvgR

0036941 (Phosphotyrosine protein) phosphatases II 50-262 1.4e-48 161.1 In-house 7-220 (297) alignment
Range on Protein: 50-262
Range on HMM: 7-220/297.0
TEKLGIDGLVKQYRKLDA-KQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
...|.. .| |....|.  . ..||.. .. ....|||| |....|..||||   .. . |||.|.||.. .|  .||. ||||..|. |||||..... 
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnv

ESILLLCKV---GREGRPRYWPSL-GVTETYGCIRVTNFSESS---EEFEICNLAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTVPQ
..|. |...   |||  ..|||.  | . ||| ..||. |...   ... . .| ||.. ..          | ..|  . ...||| |||.   . .  
tvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng..........esrtvthfhytgwpdhgvpespaslldf

RLLAQV------RHGPCVVHCSAGKDR
  |..       ..|| .||||||. |
ielvrkvlkllpsggpvlVHCsaGvgR

0045450 (Phosphotyrosine protein) phosphatases II 35-262 1.8e-48 161.2 In-house 6-247 (307) alignment
Range on Protein: 35-262
Range on HMM: 6-247/307.0
DHLQYLKALENFIFSTEKLGIDGLVKQYRKLDAKQDP---SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS--RHGDYIHANYV--------KTNYL
...  .. |. ... . . .. || |...||   ...   . .. .. . ..|||| |....|..||||.  ..   ..|||.|.||        .. .|
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

RSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRP---RYWPSLGVTETYGCIRVTNFSESSEE-FEICNLAVTFVpdnvpvdeqPANLEGLR
  .||. ||||..|. |||||..... . |. |..    ||.   .|||. | . ||| ..||. ||. .. . . .| ||             . |...
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.........dgtgesrt

VSLIKWPNWPDCGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGKDR
|  . ...||| |||.   ...    ...       ..||..||||||..|
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgR

0050432 (Phosphotyrosine protein) phosphatases II 41-262 2.2e-48 160.5 In-house 27-245 (308) alignment
Range on Protein: 41-262
Range on HMM: 27-245/308.0
KALENFIFSTEKLGIDGLVKQYRKLDAKQD-PSLTYDAYTKYMHKNRYCDVVCLDNSRVKLkidkSRHGDYIHANYVKTN--YLRSTFICSQGPLQHTII
  |.   .  ..|.. .| .....| .... .. .. .  . ..|||| |....|.|||||    . . |||.|.||..   .|. .||. ||||..|. 
svldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntve

DFWRMIFQERAESILLLCKVGREGR---PRYWPSL--GVTETYGCIRVTNFSESSeE--FEICNLAVTFVPdnvpvdeqpaNLEGLRVSLIKWPNWPDCG
|||||..... . |  |.|    ||   ..|||.   | ...|| ..||. || . .  . . .| .|..           . | ..|  . ..|||| |
dFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlg..........dgesrtvthfhytnWpdhg

VPD--EKCHTVPQRLLAQVRHGPCVVHCSAGKDR
||.  | . .  ...  . ..||.|||||||  |
vPpspeilldflelvrkslpggpivVHCsaGvGR

0046845 (Phosphotyrosine protein) phosphatases II 58-267 2e-47 157.3 In-house 2-222 (284) alignment
Range on Protein: 58-267
Range on HMM: 2-222/284.0
LVKQYRKLDAKQDP---SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS--RHGDYIHANYVKTN-----YLRSTFICSQGPLQHTIIDFWRMIFQER
| .....|   . .   ||.. .. ....|||| |....|.||||||  ..   ..|||.|.||..      | . .||. ||||..|. |||||.....
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AESILLLCKVGREG---RPRYWPSLGVTETYGCIRVTNFSESS-EEFEICNLAVTFVPDnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPD------EKCH
.. |  |..    |    ..|||. | . ||| ..||. ||   . . . .| .|..           . | ..|  . ...||| |||.      | ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.........tgesrtvthfhytswpdhgvppspedlleflr

TVPQRLLAQVRHGPCVVHCSAGKDRLYVVC
.| . | .  ..|| |||||||. |  ...
lvrellenlpgggpivVHCsaGvgRtGtfi

0047943 (Phosphotyrosine protein) phosphatases II 50-267 5.9e-46 152.5 In-house 6-223 (273) alignment
Range on Protein: 50-267
Range on HMM: 6-223/273.0
TEKLGIDGLVKQYRKLDAKQD-PSLTYDAYTKYMHKNRYCDVVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
...||...| .....|   ..  . .. .. ....|||| |....|.|||||   .. . |||.|.||.. .|  .||. ||||..|. |||||......
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

ESILLLCKVGREGR---PRYWPSLGV--TETYGCIRVTNFSESS-EEFEICNLAVTFVPdnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDEKCHTVPQR
. |  |...   ||   ..|||. |   ..||| ..||. || . . . . .| .|..           . | . |  . ...||| |||.   . .   
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg..........tgesrtvthfhytgwpdhgvppslesllefi

LLAQV------RHGPCVVHCSAGKDRLYVVC
 |..       ..|| |||||||. |  ...
elvrkalealpsngpvvVHCsaGvgRtgtfi

0039614 (Phosphotyrosine protein) phosphatases II 39-262 2.2e-45 150.8 In-house 15-235 (297) alignment
Range on Protein: 39-262
Range on HMM: 15-235/297.0
YLKALENFIFSTEKLGIDGLVKQYRKLDAKQDPsLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS--RHGDYIHANYVKTNYL-RSTFICSQGPLQHT
.|..|. ... . .... .| ... .|   ...  .. .  . ..|||| |....|.||||||  ..   . |||.|.||.. .|   .||..||||..|
plsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IIDFWRMIFQERAESILLLCKVGREG--RPRYWPSLGVteTYGCIRVTNFSES-SEEFEICNLAVTFvpDNVPvdeqpanlegLRVSLIKWPNWPDCGVP
. |||||..... ..|. |.|    |   ..|||. |   ||| ..||. ..   . . . .| ||   .. .          . |  . ...||| |||
vedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..nges..........rtvthfqytgwpdhgvp

DEKCHTVPQRLLAQV------RHGPCVVHCSAGKDR
.   .      |..       ..||..||||||..|
pslellleflelvrealaelpkggpvlVHCsaGvgR

DSPc_SM00195 59-267 2.9e-45 150.0 In-house 3-213 (263) alignment
Range on Protein: 59-267
Range on HMM: 3-213/263.0
VKQYRKLDAKQDP-SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
 ....||.... | . |  .  | ..|||| .... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VGRE---GRPRYWPSL-GVTETYGCIRVTNFSESSEE--FEICNLAVTFVPDnvpvdeqpanLEGLRVSLIKWPNWPDCGVPD--EKCHTVPQRLLAQVR
   .      ||||.  | .||.| |.|.. .. ...  ... .| .|.  .           |  .|  ... |||| ||||  ...  . . .  . .
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksks

--HGPCVVHCSAGKDRLYVVC
  .||.||||||| .|  ...
tssgpivVhCsaGvgRtgtfv

PTPc_SM00194 59-267 2.9e-45 150.0 In-house 3-213 (263) alignment
Range on Protein: 59-267
Range on HMM: 3-213/263.0
VKQYRKLDAKQDP-SLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
 ....||.... | . |  .  | ..|||| .... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
keefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

VGRE---GRPRYWPSL-GVTETYGCIRVTNFSESSEE--FEICNLAVTFVPDnvpvdeqpanLEGLRVSLIKWPNWPDCGVPD--EKCHTVPQRLLAQVR
   .      ||||.  | .||.| |.|.. .. ...  ... .| .|.  .           |  .|  ... |||| ||||  ...  . . .  . .
eeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..........eetrkvtqyqyknWpdhgvpdstksvlellravkksks

--HGPCVVHCSAGKDRLYVVC
  .||.||||||| .|  ...
tssgpivVhCsaGvgRtgtfv

0043336 (Phosphotyrosine protein) phosphatases II 43-262 6e-45 149.2 In-house 7-223 (278) alignment
Range on Protein: 43-262
Range on HMM: 7-223/278.0
LENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|....    . .  .| ... .|.  . .. .. .. . ..|||| |....|.|||||. .... . |||.|.||..     .||..||||..|. ||||
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

MIFQERAESILLLCKVGREG---RPRYWPslGVTETYGCIRVTNFSES-SEEFEICNLAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDekCH
|..... ..|. |..    |     .|||  | ..||| ..||. .|   . . . .| ||   |.          | . |  . ...||| |||.    
mvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdg..........esrtvthyhylgwpdhgvpe..sl

TVPQRLLAQ------VRHGPCVVHCSAGKDR
.  ...| .       ..|| .||||||..|
sllldflkavrealedsngpvlVHCsaGvgR

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 265-331 1.2e-44 147.1 In-house 61-127 (310) alignment
Range on Protein: 265-331
Range on HMM: 61-127/310.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
|||||.|||||||||||..||||||||||||||||||||||||||||||||||||||||||||||||
vvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

0045098 (Phosphotyrosine protein) phosphatases II 64-262 1.1e-43 145.0 In-house 16-219 (278) alignment
Range on Protein: 64-262
Range on HMM: 16-219/278.0
KLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKlkidksrhgDYIHANYVKTNylRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKV---GRE
.|   .  . |.  | . ..|||| |....|.||||         |||.|.|...   . .||. ||||..|. |||||..... ..|. |...   |||
llllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgre

GRPRYWPSlGVTETYGCIRVTNFSESSEefeicNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQV-------------
  ..|||. | ..||| ..||..||.       .  .. .   . .  ....|| . |  .....||| |||..  ..  ..|| ..             
kcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

------RHGPCVVHCSAGKDR
      ..||..||||||..|
slllldsggpvlVHCsaGvgR

0040439 (Phosphotyrosine protein) phosphatases II 74-262 1.4e-41 138.1 In-house 4-192 (249) alignment
Range on Protein: 74-262
Range on HMM: 4-192/249.0
TYDAYTKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWPSl
..  . . ..|||| |....|.|||||.| ..  ..|||.|.|... |   .||. ||||..|. |||||..... ..|. |..     ||.  .|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

GVTETYGCIRVTNFSESSeE--FEICNLAVTFVpdnvpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQV------RHGPCVVHCSAGKD
| . .|| ..||..|. . .  . . .| .|..           . | ..|  | ...||| |||.   ...    ...       ..||..||||||..
ggsleygdftvtllsvev.kddytvrtleltnl..........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

R
|
R

Y_phosphatase Protein-tyrosine phosphatase 82-262 5e-41 136.0 Pfam-A 2-183 (235) alignment
Range on Protein: 82-262
Range on HMM: 2-183/235.0
MHKNRYCDVVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGR---EGRPRYWP-SLGVTETYGC
..|||| |... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|...     |  ..||| . . ..||| 
kkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

IRVTNF-SES--SEEFEICNLAVTFVPDNVpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGKDR
|.|..  .|.  ..|. . .| ..   ..          |  .|. . . |||| |||... . .   ...  .   ..||.|||||||  |
ikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgR

Y_phosphatase Protein-tyrosine phosphatase 82-262 5e-41 136.0 In-house 2-183 (235) alignment
Range on Protein: 82-262
Range on HMM: 2-183/235.0
MHKNRYCDVVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGR---EGRPRYWP-SLGVTETYGC
..|||| |... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|...     |  ..||| . . ..||| 
kkknRykdilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygd

IRVTNF-SES--SEEFEICNLAVTFVPDNVpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTV--PQRLLAQV--RHGPCVVHCSAGKDR
|.|..  .|.  ..|. . .| ..   ..          |  .|. . . |||| |||... . .   ...  .   ..||.|||||||  |
ikvelkekekedekeytlrklelkkkkees.........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgR

subfamily_PTPRD_pd Subfamily PTPRD 56-262 6.1e-40 132.4 In-house 23-227 (564) alignment
Range on Protein: 56-262
Range on HMM: 23-227/564.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
  . ..|.|.. .|  . .  ..    .|||| ..|  |.|||.| |...    ||| |.....   | ..| .||||..|| |||||..... ..| .|
lkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVml

CKVGREGR---PRYWPSLGvTETYGCIRVTNFS-ESSEEFEICNLAVtFVPDnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDEKCHTVP----QRLLAQ
 |.  .|.    .|||. | ||||| . ||  . |  ...||... .    .         . |   |   .. .||| |||.. .. .      | |..
tkleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfkl.kkkk.........ssesreVrqFhFtsWPdhgvpesatslLdlirkvralne

VRHGPCVVHCSAGKDR
  .|| |||||||  |
pdagPivVhCSaGVGR

0042113 (Phosphotyrosine protein) phosphatases II 78-262 7.8e-40 132.2 In-house 6-189 (245) alignment
Range on Protein: 78-262
Range on HMM: 6-189/245.0
YTKYMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSlGVTE
. . ..|||| |....|..||||. |... . |||.|.||.. .   .||..||||..|. |||||..... ..|. |..    ||   ..|||. | . 
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.gesl

TYGCIRVTNFSESSeEFEICNLAVTFVPDnvpvdeqpANLEGLRVSLIKWPNWPDCGVPD-----EKCHTVPQRLLAQVRHGPCVVHCSAGKDR
||| ..||. || . . ...   .. ...         . | . |  . . .||| ||||     ....   .. ||. ..||..||||||..|
tygdftvtllseeh.lddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgR

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 46-262 7.1e-38 125.3 In-house 6-222 (307) alignment
Range on Protein: 46-262
Range on HMM: 6-222/307.0
FIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQ
..  | . |.. || ..|.|  |.  ..| .|..   .|||| || | |..|. .|.|     |||||||. .      |||.||||. |. .|| |. |
wvqrtldkgvqalvdefrvlakktpegvtveafsantdknryqdvkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiq

ERAESILLLCKVGREGR---PRYWPSLGvtetyGciRVTNFSESSEEFEICNLAV-TFVPDNVPVDEQPANLE----GLRVSLIKWPNWPDCGVPDEKCH
|. ||...||||   ..    .|||        |  .   |.|...   . || . .. ||.  ..    ...       .. ..| |||| |||. .  
ekvesvimlckvielakikceqywplee.....g..qklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinlt

TVPQRLLAQVRHGPCVVHCSAGKDR
..      .  . | |||||||  |
ainlleavrydtnpvvvhcsaGvGr

subfamily_PTPRG_pd Subfamily PTPRG 54-260 3.9e-37 122.7 In-house 17-231 (563) alignment
Range on Protein: 54-260
Range on HMM: 17-231/563.0
GIDGLVKQYRKLDAKQDPS-LTYDA--YTKYMHKNRYCDVVCLDNSRVKLKIDKSRHG--DYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
|  |. ... .|  .  .. |....   ..  .||||...|  |.|||||.     ..  ||| |||..  .    || .||||..|. ||||||.....
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

ESILLLCK---VGREGRPRYWPSlGVTETYGCIRVTNFSEsseEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHT---VPQR
. | .. .    ||.  ..|||.   .|||| ..||  .|   |  ..    |.|  |. ....    . ..|   ....|||.|||. .      | ..
aiivmitnlvergrrkcdvYWPk.desetygalqvtliee...evlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

LLAQVR-HGPCVVHCSAGK
  |. .  || ||||||| 
saankaeaGPivvHcsaGv

subfamily_PTPRB_pd Subfamily PTPRB 56-262 4.8e-36 119.3 In-house 25-231 (293) alignment
Range on Protein: 56-262
Range on HMM: 25-231/293.0
DGLVKQYRKLDA-KQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILL
 .....| .| | ..| . . .  ..   |||| ...  |.||||| ....... ||| |||.. .  .  || .|||| .|. |||||....... |..
lrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivm

LCKVGREGR---PRYWPSLGVTETYGCIRVTNFSES-SEEFEICNLAVTFvpdnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDEKC------HTVPQRL
| ..  .|.    .|||.   . .|| |.||  .|.  |.. | .|...             . |  .|   ..  ||| |||..        .|| ...
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek............ekeerkvrqyhftsWpdhgvPektktlldfvrtvreai

LAQVRHGPCVVHCSAGKDR
  . ...| |||||||  |
ektaskrPivvhCsaGvGR

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 41-262 2e-35 117.5 In-house 12-236 (298) alignment
Range on Protein: 41-262
Range on HMM: 12-236/298.0
KALENFIFSTEKLGIDGLVKQYRKLDAKQD--PSLTYD--AYTKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHT
.||...   ..| .. |. .....|.. ..  .. ...   ...  .||||.|.. || ||| |.  |.  ..||| | ....   |..|| .|.||..|
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

IIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGvTETYGCIRVTNFSES-SEEFEICNLAVTfvpdnvpvdEQPANlEGLRVSLIKWPNWPDCGV
. |||||. .| ...| .| ..   ..   ..|||. | .|||| |.|.  |.    ......|.|.         ..  . .  .|  ... .||| ||
vedFWrmvteedigtiVmltnleeldktkyhkywPdeg.ketygeitvsllskeefadlivrklkvs.........kkkee.kerevrqlhftsWpdkgv

PDEKCHTVPQRL---LAQVRHG--PCVVHCSAGKDR
| ...  .  .      | . |  | .|.|||| .|
penatsvldllrkvrasqqqagnkpvivqCsaGvgR

subfamily_PTPN6_pd Subfamily PTPN6 48-262 5.4e-35 115.9 In-house 21-240 (306) alignment
Range on Protein: 48-262
Range on HMM: 21-240/306.0
FSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYL--RSTFICSQGPLQHTIIDFWRMIFQ
 |.|| |.    .. .. .||.  | .  | .....||||  ..  |..||.|| ..    ||| |||.|..    . ..| .|| |..|. |||||..|
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

ERAESILLLCKV---GREGRPRYWPSLGVTETYGCIRVTNFSESS-EEFEICNLAVTFVpdnvpvdeqPANLEGLRVSLIKWPNWPDCGVPDEKCHT---
| .. |... |    |.|   ||||.   .|.|| |.||| ||.| ..... .| |. .           . |  .|   .. .||| ||| .. .    
ensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.........kkkkeerevfqyhfksWPdhgvpkdpgavLdf

---VPQRLLA--QVRHGPCVVHCSAGKDR
   | ..     . ..|| |||||||  |
ledvnrkqeeleeaeagpivvhCsaGiGR

0037934 (Phosphotyrosine protein) phosphatases II 81-262 6.1e-35 116.3 In-house 10-191 (243) alignment
Range on Protein: 81-262
Range on HMM: 10-191/243.0
YMHKNRYCDVVCLDNSRVKLkidksRHGDYIHANYVKTNylrSTFICSQGPLQHTIID----FWRMIFQERAESILLLCKV---GREGRPRYWPslGVTe
 ..||||.|....|.|||||       .|||.||...      ..|..||||..|. |    ||||..... ..|. |..    |||. ..|||  | . 
nlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp..gev.

TYGCIRVTNFSESSEE-FEICNLAVTFVP-DNVPvdeqpanlegLRVSLIKWPNWPDCGVPDE--KCHTVPQR----------LLAQVRHGPCVVHCSAG
||| ..||. ||.. . . . .| .. .. |...          . |  . . .||| ||||.   .    .           |||  ..||..||||||
tygdftvtllseehlddytvrtlllenldlddlt..........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

KDR
..|
vgR

subfamily_Ptp69D_pd Subfamily Ptp69D 55-263 7.2e-35 115.6 In-house 21-233 (307) alignment
Range on Protein: 55-263
Range on HMM: 21-233/307.0
IDGLVKQYRKLDAKQDP-SLTYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESIL
  ||.| |.|| |.. . | .  .      |||| |..  |. ||||| |  . . ||| |...|.   . .||..|.|.. || |||||| .   . | 
dfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtliv

LLCKVGREGR---PRYWPSLgVTETYGCIRVTNFSES-SEEFEICNLAVTFVPDNVPvdEQpanLEGLRVSLIKWPNWPDCGVPdEKCHTVP---QRL--
.| ...   |   ..|||    .  || | |.  ||.  ... | .| |. . ....  |     .  .|   .. .|.|  || | ....    ...  
mlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesg..ev...edsrkvvqyhytgWkDskvP.evargllklieqvre

LAQVRHGPCVVHCSAGKDRL
| .  ..| ||||||| .| 
lyklnrsPivvhCsaGvgrs

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 81-262 1e-34 114.7 In-house 48-232 (305) alignment
Range on Protein: 81-262
Range on HMM: 48-232/305.0
YMHKNRYCDVVCLDNSRVKLkiDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRP---RYWPSLGVTE---T
  .|||| || |||| ||||  . .   .||||||| |      |||.| ||..|  ||| | .|.. |.|..||..   |      |..|    .    
eagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

YGCIRVTNFSESSEEFEICNLAVTFVPDNVPVDEQPANlEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKDR
 .  ...   |||..... . | . | . | | | | . . ..|.  .| .||| |||      .     |.. .|| |||||||  |
ekgqkisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigr

subfamily_PTPN12_pd Subfamily PTPN12 77-267 1.4e-33 111.1 In-house 36-225 (290) alignment
Range on Protein: 77-267
Range on HMM: 36-225/290.0
AYTKYMHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVT
  .. ..|||| |..  |.|||.|. ... .  ||| ||..|  . . ..| .|||| .|. ||||||.. . | ....|..   |.    ||||. | .
ekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegee

ET-YGCIRVTNFSESS--EEFEICNLAVTFVpdnvpvdeqpanLEGLRVSLIKWPNWPDCGVPDEKCHTVP----QRLLAQVRHGPCVVHCSAGKDRLYV
|. .| ..||. .|    ..| |  |.|..              |  .|  ... .||| |||  . . .      | | .  . | |||||||  |  .
elefgefevtleeekavdddflirtLkveaq............kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGt

VC
..
ii

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 42-262 2.8e-33 109.9 In-house 10-234 (305) alignment
Range on Protein: 42-262
Range on HMM: 10-234/305.0
ALENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTK------YMHKNRYCDVVCLDNSRVKLkiDKSRHGDYIHANYVKTNYLR-STFICSQGPLQH
 .|.|.  .  .|.| | ...|.|     | .|  |.         . |||| || | |.| |||  ||    ||||||||    .    |||.||||..
iveqfvlraldvgvdklreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldq

TIIDFWRMIFQERAESILLLCKVGREG---RPRYWPSL-GVT-ETYGCIRVTNFSESSEEFEICNLAVTFVpdNVPV-DEQPanlegLRVSLIKWPNWPD
|| .|| |. |.. | |..|||    |     .|||   |   |  . | | | | |       .. .| .  |.    .|      . |  ..| .|||
tidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitll..nltysgdqk.....msvrhlqwtewpd

CGVPDekCHTVPQRLLAQVRH--GPCVVHCSAGKDR
 |||   |.     ||. .|    | |||||||  |
rgvpp..ckltslellsairgskvpivvhcsagigr

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 50-265 3.6e-33 110.0 In-house 14-229 (318) alignment
Range on Protein: 50-265
Range on HMM: 14-229/318.0
TEKLGIDGLVKQYRKLDAKQDPSLTYDAYTK-YMHKNRYCDVVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQER
 .. |   | ..| .|. ... . .... ..   .|||| ...  |..||||.  . .   ||| |||.  .  . ..| .|.|| .|| |||||...  
lresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqn

AESILLLCKVGREGR---PRYWPSLGvTETYGCIRVTNfsesSEEFEICNLAVTfvpdNVPVDEQPANlEGLRVSLIKWPNWPDCGVPDEKCHTVP----
.  |..| ..  .|.    ||||| | ...|| ..|.     .||.|. .. .     .. | ..  . |   |   .. .||| |||.. .. .     
savivmltqeeergkakvhryWPskg.srsygklvvel....keevelsdyvlr....efkvtrteee.esrqvrqyhytsWpdegvpesgaslldlvrq

-QRLLAQVRHGPCVVHCSAGKDRLYV
 ..  ..  .|| |||||||  |  |
vskaqqksgagpivvhCsaGvGrtGv

subfamily_PTPN3_pd Subfamily PTPN3 53-265 6.4e-33 108.9 In-house 12-224 (280) alignment
Range on Protein: 53-265
Range on HMM: 12-224/280.0
LGIDGLVKQYRKLDAKQD-PSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLR----STFICSQGPLQHTIIDFWRMIFQER
|    ...|. .|  |.   ...    .. ..|||| |..  |. |||||  ..   ||| ||||. .         .| .||||..|  |||.|.....
lesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqk

AESILLLCKVGREGR---PRYWPSLGVTETYGCIRVTNFSEsseefeicNLAVTFVPDNVPVDEQPANlEGLRVSLIKWPNWPDCGVPDEKCHTVP----
.. |..|  .  .||    .|||. . . .||...|.  .|        .   ..|  .. . .. .. |  ..  ... .||| ||||.. . .     
sslivmlttlverGrvkChqyWPetedeleygefsvkceke........detksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefver

QRLLAQVRHGPCVVHCSAGKDRLYV
 | | .... | ||||||| .|  |
vrklrsgkeePvvvhCsaGigrtGv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 81-262 7.5e-33 108.8 In-house 9-188 (250) alignment
Range on Protein: 81-262
Range on HMM: 9-188/250.0
YMHKNRYCDVVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG--RPRYWPSlGVTETYGC
  .|||| |.. ||.||| |. .|  .. ||| | ....   |..|| .|||||.|| |||||...| ...|..| ..  ..   ..|||   ..|.|| 
nkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv.ekaekyGd

IRVTNFSES-SEEFEICNLAVTfvpDNVPVDEQpanleglRVSLIKWPNWPDCGVPDEKCHTV-----PQRLLAQVRHGPCVVHCSAGKDR
..|. .|.    .... .| ..    .   ||.        |  ... .||| |||..    .      |.   |.  .| .|.||||  |
vtvsllskeefadytkrklkls...kakkader.......ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 42-262 9.1e-33 108.1 In-house 13-229 (290) alignment
Range on Protein: 42-262
Range on HMM: 13-229/290.0
ALENFIFSTEKLGIDGLVKQYRKLDAKQDP-----SLTYDAYTKYmHKNRYCDVVCLDNSRVKLKidKSRHGDYIHANYVKTnyLRSTFICSQGPLQHTI
|.|.|  .. | ..|.| |.| .      |        .|. |.. .|||| |||| | .|| ||     .|||.||||||   |...|| .||.|. |.
afekfasdvvkknvdelakeyleklkpylpvqylerkifdkntef.kknrykdvvcndktrvilk..dGydGdyvhanyvkG..lkamfiltqGalkdtv

IDFWRMIFQERAESILLLCKVGREGRPR---YWPS-LGVTETYGCIRVTNFSESSEEFEICNLAVTFVpDNVpvDEQPAnleglRVSLIKWPNWPDCGVP
||.|||. ||..  | .||..  .|...   |.|   | . |.| | |.   |.... .|    ..   |    . .       ..  .|   |||  |.
idiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvr.dkd..sGkeh.....klkhlkikswpdksva

DEKCHTVpqRLLAQVR--HGPCVVHCSAGKDR
  .   .  |.|  .|   || |||||||  |
lstlall..rtlrilrkasGpvvvhcsaGiGr

subfamily_PTPN23_pd Subfamily PTPN23 57-268 4.7e-32 105.9 In-house 16-231 (288) alignment
Range on Protein: 57-268
Range on HMM: 16-231/288.0
GLVKQYRKLDAKQDPS---LTYDAYTKYMHKNRYCDVVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRS-TFICSQGPLQHTIIDFWRMIFQERAESIL
.| |....|. |||      .  .  .| .|||. |..  |..||||.   . . ||| | .||     . .||..|.||| |. |||.|....... | 
aldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviV

LLCKVGREGRP---RYWPS-LGVTETYGCIRVTNFSESSEEfeicnlavTFVPDNVPVDEQPANLEgLRVSLIKWPNWPDCGVPD------EKCHTVPQR
.| .    |.|   ||||.  | |...| ..||  |. . |        |.|  .. .. ..|.     ||.... .||. |||.      .  . | . 
mllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvrete........thvervlkletldadav.ksvshlqltsWpelGvPasPetllqfldevesa

--LLAQVRHGPCVVHCSAGKDRLYVVCL
     .  . | ||||||| .|  |..|
yeavqrksktPlvvhCsaGvgRtgvfal

subfamily_PTPN9_pd Subfamily PTPN9 44-238 5.8e-32 105.9 In-house 4-195 (297) alignment
Range on Protein: 44-238
Range on HMM: 4-195/297.0
ENFIFSTEKLGIDGLVKQYRKLDAKQDPS-LTYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|...   .. |. ||.|.| .. ...    ...      ..|||| ||.|.|..||.|. .|.  . |||.||.|     . .||  ||||..|. ||||
eelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWr

MIFQERAESILLLCKVGREGR---PRYWP-SLGVTETYGCIRVTNFSES-SEEFEICNLAVtfvpDNVPVDeqpanlEGLRVSLIKWPNWPDCGVPDEKC
|......  |..  .|  .||    .||| . . .. .| ..|.| .   .|....  | .    .||  .      |  .|.  .   ||| |||..  
mvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvlei....knvkte......esrkvthfqflsWPdyGvPssaa

HT
  
sl

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 52-259 8.4e-32 105.4 In-house 17-222 (288) alignment
Range on Protein: 52-259
Range on HMM: 17-222/288.0
KLGIDGLVKQYRKL-DAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAE
. . .|....|..|   ... | |    ..  .|||| ... .|  |||||  .. .  ||| |.|.. .  . ..|..||||..|. |||.........
arnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

SILLLCKV---GREGRPRYWPSLGVTETYGCIRVTNFSESSEEfEICNLAVTFVpdnvpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQ
 |. | ..   |..   .|||. .  . || . ||  ..  .| .. .  .  .           . . |..   ..  ||| |||. |   .  .   .
tivmltelveggktkCeeYWPdadkpknyGsvtvtlveskele.dfvlrkllle..........kkkteleitqyqylaWpdhgvPeskapllellrqvk

VR----HGPCVVHCSAG
|      || .||||||
vanqadtgpiivhCsaG

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 54-262 1.5e-31 104.5 In-house 13-221 (281) alignment
Range on Protein: 54-262
Range on HMM: 13-221/281.0
GIDGLVKQYRKLDA--KQDPSlTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAES
   |....|.|| |   .... |     . ..|||| ..|  |..|||. . ... . ||| ||.|..      .| .|||. ... .||.|....... 
dnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsa

ILLLCKVGREGR---PRYWPSLGVTETYGCIRVTNFSESSEEfeicnlavTFVPDNVPVdEQpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLA--
| .. .   .|.    ||||    . .|| ..|.. .|....        |..  .. . |.  . |  .|. ... .||| |||..  . .  |     
ivmvtreieagklkChrYWPddnselkygdvtvkstaeeeka........tyierkfkl.er.esgetreveqlaytaWPdhGvPattkellefrkevlk

-QVR--HGPCVVHCSAGKDR
 . .  . | |.|||||  |
ltekktkaplvihCsaGvGr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 41-262 3.4e-31 103.5 In-house 7-229 (305) alignment
Range on Protein: 41-262
Range on HMM: 7-229/305.0
KALENFIFSTEKLGIDGLVKQYRKLDAKqDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDF
. |...|.....   .|| .||..|  . . |.  .  ..  .|||. ... ||..|..|. ..| .  ||| |.||..   . ..| .||||..|. ||
ddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf

WRMIFQERAESILLLCKVGREGR---PRYWPSLG-VTETYGCIRVTNFSE-SSEEFEICNLAVTFVPDnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDE
||.|..|. ..|..|.|.  .|.    .|||     .. .| . |.  || . ... . .| ...  .         . |.  |.  .  .||| |||..
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.........dkesrtvlqyqltdWPdhGvpqf

KCH--TVPQRLLAQVRHG---PCVVHCSAGKDR
     .. .|.  . ...   | .||||||  |
atsllslikrvqkdqkkdkgvpllVhCsagvgR

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 46-262 3.8e-31 102.8 In-house 1-213 (281) alignment
Range on Protein: 46-262
Range on HMM: 1-213/281.0
FIFSTEKLGIDGLVKQYRKLDAKqDPSLTYDAYTK--YMHKNRYCDVVCLDNSRVKLKI--DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
| .|..|. .| . ... .|     ||    .. .    .|||| .. ||| |||.||.   .    |||||||... .|.  .| .||| . |  ||||
famssqkmtlddfkqefsnlpgd.ppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwr

MIFQERAESILLLCKVGREGR---PRYWPslgvTETYGCIRVTNFSESSEEFEICNLAVTfVPDNVPVDEqpanlEGLRVSLIKWPNWPDCGVPDEKCht
||.|| . .|..||..    |     |.|     ... |... ..| | |.  . .  ||    |.  .      |   ..   | .|||  ||.     
miwqenttaivmlcqfletnrekcaeyfp....rnahcclqfdklsvsyedstvnkslvt.trlnlsyeg.....etrlithwlwkewpdwqvpesse..

VPQRLLA--QVRHGPCVVHCSAGKDR
|  ..|   . |  | |.|||||  |
vmlkilrkirarstppvihcsagvgr

subfamily_PTPRA_pd Subfamily PTPRA 79-263 5.1e-31 102.8 In-house 56-242 (330) alignment
Range on Protein: 79-263
Range on HMM: 56-242/330.0
TKYMHKNRYCDVVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGRE---GRPRYWPSLGVTeT
 . ..|||. ...  | ||| |   .   . ||| | ...    . .|| .|||...|. ||||||.. .. .|..| ..         .|||. |.  |
eenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlv.t

YGCIRVT-NFSESSEEFEICNLAVTFVPDNVPVDEQpaNLeglrVSLIKWPNWPDCGVPDEKCHTVP----QRLLAQVRHGPCVVHCSAGKDRL
|| |||. . .. .... . .. |. .||.   ...   |    |. ...  ||| ||| |    .      . | |.  || |||||||  | 
yGnirvevedetvlvdytvrkflvqqlpdatrekks..rl....vrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrt

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 79-262 9.1e-31 101.9 In-house 26-214 (274) alignment
Range on Protein: 79-262
Range on HMM: 26-214/274.0
TKYMHKNRYCDVVCLDNSRVKLKIDKSRH--GDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLG--
..  .||||....  .|||| |. ..|..   .|| |||.|  ..   ...  ||||..|. ||||||.||... |..| |.  . .    .|.|     
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

-VTETYGCIRVTNFSE-SSEEFEICNLAVTFVPDNVPvdeqpanleglrVSLIKWPNWPDCGVPDEK------CHTVPQ-RLLAQVRHGPCVVHCSAGKD
 ..|.|| . ... .  . ..... .| .  . ..              |  . ...|||  .||.       .. | . |  .. . .| |||||||  
eiserygdveikvekiverndysvrklvlkylerers............vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiG

R
|
r

subfamily_PTPRK_pd Subfamily PTPRK 82-263 1.5e-30 101.1 In-house 44-224 (314) alignment
Range on Protein: 82-263
Range on HMM: 44-224/314.0
MHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG---RPRYWPSLgvTETYGC
 .|||. |..  |.|||.|. ||   . ||| |... .    . ||  |||||.|. ||||....|.. ||..| ..  .|     .|||    ||.|| 
reknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed..tevygd

IRVTNFSESSEEfEICNlaVTFVPDNvpvdEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTV---PQ-RLLAQVRHGPCVVHCSAGKDRL
|.|.  . . .. |. .   .|   .     . .  |   |  ... .||| .|| ..   .    .     . ..|. |||||||  | 
ikvelvetella.elvv..rifrvek....largqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrt

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 43-262 2.2e-30 100.8 In-house 10-229 (319) alignment
Range on Protein: 43-262
Range on HMM: 10-229/319.0
LENFIFSTEKLGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
|.. .   .. |  .| |....|.  .. ...     .  .|||| ...  |..||.| ..| .   ||| |... .   |. ||  |.||..|| ||||
LkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MIFQERAESILLLCKVGREGR---PRYWPSLGvTETYGCIRVTNFS-ESSEEFEICNLAvtfvpdnvpVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCH
|...|..  ...|.|.  ...    .|||.    |.|| . ||  . |  |...| .|          .... ...|  .|.  .. .||| .||..   
mvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklk.........lnkkssevetRevkhfqyteWpdhdvPekats

TVP--QRL---LAQVRHGPCVVHCSAGKDR
 .   .|.     .  .|| |||||||  |
lldllkrirksrektqsgPivvhCsaGvGR

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 74-263 9.1e-28 92.5 In-house 54-238 (319) alignment
Range on Protein: 74-263
Range on HMM: 54-238/319.0
TYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCkvgREGRPRYWPSLGV-
|.    .   |||. ...  |...|||. ..     ||| | .|.    .  .| .||||. |. ||||||.. .. .|.||    ..   .|||  .| 
tfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt...kdkcsqywplkivi

TETYGCIRVTNFSESSEefeicnlavtFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCSAGKDRL
.|  . ..|.   |..|          .|  .. . |.  . .  ..   ..  ||| ||||     .    . | | .  .   . |||||||  | 
keerfkvkvdsveetae..........yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrt

0041856 (Phosphotyrosine protein) phosphatases II 82-262 1.3e-27 92.0 In-house 2-122 (182) alignment
Range on Protein: 82-262
Range on HMM: 2-122/182.0
MHKNRYCDVVCLDNSRvklkidksrHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCkvgregRPRYWPslgvtetygcirvt
..|||| |... |.||         . |||.||..  ..  ..||. ||||..|. ||.||. ...  .|. |.       ..|||              
ldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywp..............

nfsesseefeicnlavtfvpdnvpvdeqpaNLEGLRVSLIKWPNWPDCGVPDekcH--TVPQRLLAQVRHGPCVVHCSAGKDR
                              .|.   .  ... .||| ||||      ..     .. ..||..||||||..|
..............................ellerlgiqylylpwpDhgvpd...ldelldfieevleeggpvlVHCsaGvgR

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 74-263 1.8e-27 91.6 In-house 18-202 (284) alignment
Range on Protein: 74-263
Range on HMM: 18-202/284.0
TYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCkvgREGRPRYWPSLGV-
|.    .   |||. ...  |...|||. ..     ||| | ...    .  .| .||||. |. ||||||.. .. .|.||    ..   .|||  .| 
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...kdkcsqywplkivi

TETYGCIRVTNFSESSEefeicnlavtFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTV---PQ-RLLAQVRH--GPCVVHCSAGKDRL
.|  . ..|.  .||.|          .|  .. . |.  . .  ..   ..  ||| ||||   . .    . | | .  .   . |||||||  | 
keerfkvkvdsveesee..........yvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrt

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 43-260 4.6e-27 89.6 In-house 7-227 (290) alignment
Range on Protein: 43-260
Range on HMM: 7-227/290.0
LENFIFSTEKLGIDGLVKQYRKLDAKQ-DPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKiDKSRHGD----YIHANYVKTNYLRSTFICSQGPLQHTII
. .|.   .. | .|  .|. .||. . . . |..  ..  ..||. ..|  |. |. |. ..| | |    ||.| |.|    .  .|  |||...|..
fgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLr.pisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

DFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVTEtYGCIRVTNFSESSEEfEICNLAVTfvpdnvpVDEQPANLEGLRVSLIKWPNWPDCG-V--
|||..| ||.   |..|...  ||.     |||. .... || ....  .|.. . |. .  .        | .. .. .   |   .  ||.. | |  
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetln.eyierkle.......vknknsagakqsvtqyqitnwdstgkvtn

PDEKCHTVPQRLLAQVRH--GPCVVHCSAGK
|    ... ..   | ..  .. |||||.. 
pqtillvieemyktqrkrgntsivvHCSdtv

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 56-262 5.2e-27 89.6 In-house 24-225 (315) alignment
Range on Protein: 56-262
Range on HMM: 24-225/315.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|. ..|  .   |   |     ..  .|||| ...  |.|||.|  ...  | ||. ||...    .  .|..|||.  .. ||||..|.|    |..|
ngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml

CKVGREG-R--PRYWPSLgvTETYGCIRVTNFSESSE-EFEICNLAVTFvPDNVpvdeqpAnleglRVSLIKWPNWPDCGVPDEKCHTV------PQRLL
 ..  .  |   .|||      .|| | ||  ||  . |. .  |.|.|  ||.             |  ...  ||| |||      .       |   
tnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvf.gdni......r.....evvqlhytswpdmgvpkytiplmnlirtvkqhht

AQVrhGPCVVHCSAGKDR
..|  |. |||||||. |
nsv..gaivvhcsaGvGr

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 47-262 8.5e-26 85.6 In-house 10-217 (288) alignment
Range on Protein: 47-262
Range on HMM: 10-217/288.0
IFSTEKLGIDGLVKQYRKLdAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKiDKSRHgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQE
|    . ...|| |.||    .. .  . |.. .   ..|| .. . | .||||. | .    ||.|| | ..  .  .||.| ||. ||  .|.|....
irlvlqiaveglkkeyrds.pneasidiidsfianptrdryenlprcditrvkls.ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmlles

RAESILLLCKVGREG---RPRYWPSLgVTETYGCIRVTNFSESSEeFEICN-LAVTFVPDNVPVDEQPanleglRVSLIKWPNWPDCGVPDEkcHTVPQR
  | |..||..   |      |.||  . |.    |. .    .   .|   . |. .  . ...|.        |  . . .|.| |||..  .  | |
dveyivmlcellekGkeksaeyfPsk.lGekarigrlctvvkkkr.adidklvkvsllriskegeekv......ivkilhlleWdddgvPen..ylsplr

LLAQVR--HGPCVVHCSAGKDR
||  ..  . | |||.|||  |
llevlkslqkPivvhssaGvGr

0051429 (Phosphotyrosine protein) phosphatases II 108-262 1e-25 86.4 In-house 4-163 (272) alignment
Range on Protein: 108-262
Range on HMM: 4-163/272.0
GDYIHANYVKTNYL---RSTFICSQGPLQHTIIDFWRMiFQERAESILLLCKVG---REGRPRYWP-----------SLGVTETYGCIRVTNFSESSEEF
..||.|..|....    . ....|.|||..|. ||||.  ...  .|. |...    |.. .||||           .   | .||..|||..||.  ..
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

eicnlavtFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAqvrHGPCVVHCSAGKDR
        .. ..  .  .  . |...| .. . .||| |||.| .... . ||.   .||..|||||||||
........yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdR

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 64-262 2.4e-25 84.1 In-house 18-216 (285) alignment
Range on Protein: 64-262
Range on HMM: 18-216/285.0
KLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKidkSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---R
|.     |  || ||      |||.|| |....|| ||    .  |||||....     .||.| .||||  |. |||.||.||.   .|.|| .     
kikgymppnctytayeanpdlnryadvrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggv

EGRPRYWP-SLGVTETYGCIRVTnFSESSEEfeicNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVP-QRLLAQV--RHGPCVVH
|    |.|  ||    .|   .| ..|  ||     .| | .     .. . |. | | .  .. | |||   |..    .   . . .|  .  | .||
ekcalyypeklgevvkfgkyeit.lteckee....aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvh

CSAGKDR
||||  |
csagvgr

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 56-264 1.2e-24 81.6 In-house 15-241 (301) alignment
Range on Protein: 56-264
Range on HMM: 15-241/301.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKS---RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESIL
... .||..|. ..| | |     .  . ||. ... .|. |. ||  ..    . .|| |.|..    .  || .|||...|..||||.|.||.  ||.
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

LLCKVGR---EGRPRYWPS-LGVTETYGCIRVTNFSES-SEEFEICNLAVTFVpDNVP---VD---EQPANLEGLRVSLIKWPNWPDCGV---PDEKCHT
 ...      .   .|||.    .|..| . ||  .|    .| | .|.|.   |      .    .  .. ..  |  ..  .||. ||   |    . 
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiq.dgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

VPQRLLAQ--VRHGPCVVHCSAGKDRLY
. . . .|  .  || |||||..  |  
iddvihrqqkigggpvvVHCSdtVsrsG

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 44-262 1.7e-24 81.3 In-house 8-224 (287) alignment
Range on Protein: 44-262
Range on HMM: 8-224/287.0
ENFIFSTEKLGIDGLVKQYRKLDA--KQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWR
 .|. . .. | .|  .|.  |.   ... ..| .  ..  .|||. ...  || || ||    .| ||| | ....   .  || ...|. .|. .||.
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWk

MIFQERAESILLLCKV---GREGRPRYWPSLGVtETYGCIRVTNFSESSEEfeicnlavTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCG-VPDEKC-
.| ... . |..||.     .|   .|||.     ..|  ...  .|  ..         ..  .. | ..  . . ..|   .  ||.. | |.. .  
liddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevna........gyierklevknknkagdkqqvkqyqitnWdstgkvtepqti

-HTVPQRLLAQVRH--GPCVVHCSAGKDR
   . ..  .| ..  .. |||||..  |
llvieemyktqrkrgntsivvhCsdtvGr

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 80-260 2.1e-24 80.8 In-house 37-221 (287) alignment
Range on Protein: 80-260
Range on HMM: 37-221/287.0
KYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPR---YWPSLGVTETYG
  ..||||.||. .|..|| |  .     ||| |||| .     .||..|||.  |. ||||.....|. |.... .   |.| .   |||   |    |
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvG

CIRVTNFSESSEEFEICNLAVTFVpdnvPVDEQPANLeglrVSLIKWPNWPDCGVPDE-----------KCHTVPQRLLaqVRHGPCVVHCSAGK
   |. .. .  | | .  |.  .     .. . |..    |  ... .||| ...             | |   .|       || |||...| 
GysvvlldydikePeygvralrli....dletrearv....vkqldllswPdkvlaPtavglirfvldvkqhielarda..sevGPlvvhddvGi

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 80-267 2.9e-24 80.5 In-house 43-228 (315) alignment
Range on Protein: 80-267
Range on HMM: 43-228/315.0
KYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPS-LGVTET
  ..|||| ... ||..||||  ||.| . ||| | |.|.     ..|.|||||. .. |||||..||.. .| .. |  .. .    .|||   . .  
infkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsve

YGCIRVTNFSESSEEFEICNLAVTFVPDnvpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTVpqRLLAQVR------HGPCVVHCSAGKDRLYVVC
.| |.|. .| ..    .    ||   .           |  .|.  .. .||| ||. .    .  .|. .|.      . . .||||||  |  ||.
fGsikvellsleadtdgvarklvtrkse...........esrtvtqfqftewPdkGvdkqtssll..klikevkadngkkefsllvhcsaGvGrtGvvi

subfamily_egg_pd Subfamily egg 69-194 3e-24 80.3 In-house 28-161 (307) alignment
Range on Protein: 69-194
Range on HMM: 28-161/307.0
QDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC-KVGREGRPRYW
.. |||  |   ...| |   | | | |||||.. . .. .|.||||.|| . |  .||..| ||. |  |||||.|||. . |..|  ..  |  . ||
deislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyyw

PSLGV---TETYGCIRVTNFSESSE---EFEICN
|           | .|..|.   |.    | . .
pkaesdslvtvpGslrienlkvdskadplfrvtk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 63-263 4.3e-24 80.0 In-house 2-211 (270) alignment
Range on Protein: 63-263
Range on HMM: 2-211/270.0
RKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVK-TNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGRE
..|| ..  . .  ....  . ||| |..   ..||.|. ...  .  || ||||.  .  . ..|...|||. |. .|||||..|....|... ..  .
keldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEk

GR---PRYWPSLG---VTETYGCIRVTNFSESSEEFeicnlavtFVPDNVPVDEQPanlEGLRVSLIKWPNWPDCGVPDEKC-HTVPQRLL---AQV---
||    ||||.     |. ..| |.|.. ||. ||.        ..  .. . |.    |  |.    . .||| ||| |.   . .. ||   ..|   
grkkCerYWpaepkekvkledgkikvlalseekeeg........yiltrlrleekg...eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrs

-----RHGPCVVHCSAGKDRL
     . .|..|||||| .| 
ekeldkaePllvHcsaGvgRt

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 60-267 6.2e-24 79.4 In-house 13-217 (283) alignment
Range on Protein: 60-267
Range on HMM: 13-217/283.0
KQYRKLDAKQDPSlTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVK--TNY-LRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.....|   . .. . ..  .  .|||. ..|  |. ||.|| .     ||| | ..    .|     .| .|.||..|..|||.|.|.|.. .|..| |
evlkrlsvpdlda.diasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

VGREGR---PRYWPSLGvTETYGCIRVTNFSES-SEEFEICNLAVTFVpdnvpvdeqPANLEGLRVSLIKWPNWPDCGvPDEKCHTV-----PQRLLAQV
.  . |    .|||. | .| ||   ||   |  |. | | .| .             .  . | ..  .  .| ..| ..    ..      . |  . 
lqedlrikCsqyWPkrG.sedyGeftvtlrkettsnsfiikelllrvn.........ssakstlllahyqvidWleyg.eqaiinslvkfnkvislqtes

RHGPCVVHCSAGKDRLYVVC
..|| |||||.|  |  | .
kkgPivvhCstgiGrtavfi

0049772 (Phosphotyrosine protein) phosphatases II 66-262 6.4e-24 80.7 In-house 31-225 (314) alignment
Range on Protein: 66-262
Range on HMM: 31-225/314.0
DAKQDPSLTYDAYTKYMHKNRYCDVVCLDnSRVKLKIDKSRHGDYIHANYVKTNylrSTFICSQGPLQHTIIDF----------WRMIFQERAESILLLC
 . .. ...   . . ..|||| |... | .||.|.    .  |||.|.||..     .||..||||..|..||          |||....   .. . .
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------KVGREGRPrywpslgvtetygcI----------RvtnfsesseefeicnlavtfvpdnvpvDEQ--PANLEGLRVSLIK
                       .  |..                         .                           .|.  |  .|.| . .. 
srdevladelsrLdaAlgKtpllildgng..............neptaadlellk...........................eelydpelferlgikylr

WpNWPDCGVPDEKCHTVPQRLLAQ-VRHGPCVVHCSAGKDR
. ..|| ..|...      ... .  ..|| .|||.|||.|
i.pvpDgsaplledfdeflefieeadkggpvlvHCkaGkgR

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 56-262 6.7e-24 79.6 In-house 23-234 (325) alignment
Range on Protein: 56-262
Range on HMM: 23-234/325.0
DGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
||. ...  | ...  . .  .  . . |||. .|| ||.||| |.  | . . ||| |.|....  . .|. .| || .|| |.||.... |.  ...|
dgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl

CKV--GREGRPRYWPSL-GVTETYGCIRVTNFseSSEEFeiCnlavTFVPDNVPVdEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVP---------QR
 ..  | .    |||   | . |.| ..|     . ||.        .|   . |  |. . | . |   ..  |.| ||.   .  ..         .|
neldlgkdrcavywpkemgksktfGglevklr..tieei..s....dyvhrvldv.kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavser

LLA-QVRHGPCVVHCSAGKDR
. |     .| .||||||  |
vtantkastpilvhcsaGvGr

subfamily_PTPN13_pd Subfamily PTPN13 79-263 9.7e-24 79.1 In-house 35-216 (273) alignment
Range on Protein: 79-263
Range on HMM: 35-216/273.0
TKYMHKNRYCDVVCLDNSRVKLKIDKSrhgdYIHANYVKTNYLRST--FICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVTE
 . ..|||| .|.  |..||||. . .    || |...| .    .  .| .|||| .|. |||.|... .|| | .. .   .|.    ||||.    .
kenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkk

T--YGCIRVTNFSesseefeICNLAvTFVPDNVPVDEQpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQ-RLLAQV--RHGPCVVHCSAGKDRL
.  .. ..|..         . .|  .||  .. | .. .  |  .|. ... .||| ||| .  . .   . ....   .|| |||||||  | 
lkvsnrlevellk.......vqkld.gfvvralavkds.esgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrs

subfamily_PTPN1_pd Subfamily PTPN1 79-268 9.8e-24 78.6 In-house 30-220 (290) alignment
Range on Protein: 79-268
Range on HMM: 30-220/290.0
TKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVTETY
 .   .||| ||   | ||.||. ..    ||| |. |. . ..  .| .|||| .|.  ||.|...... ....| ||  ...    .|||.   ... 
penrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekel

G----CIRVTNFSE-SSEEFEICNLAVTFvpdnvpvdeqPANLEGLRVSLIKWPNWPDCGVPDEKCHTVpqRLLAQVR--------HGPCVVHCSAGKDR
      ..|.  || ..... .  | ..               |   ..  ..  ||| |||.     .  ..| .||        .|| |.|||||  |
lledtklkvkliseerksyytvrllelen..........lktqetreilhfhyttwpdfgvpespaafl..kflfkvresGslssdvGpavihcsaGiGr

LYVVCL
   .||
sGtfcl

DSPc_SM00195 265-331 1.2e-23 79.2 In-house 35-102 (263) alignment
Range on Protein: 265-331
Range on HMM: 35-102/263.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
ilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

PTPc_SM00194 265-331 1.2e-23 79.2 In-house 35-102 (263) alignment
Range on Protein: 265-331
Range on HMM: 35-102/263.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| ...  . |||.|||.|..  ....|. ||||..|. |||||...|. . |. |..
ilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlte

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 83-267 1.3e-23 77.9 In-house 45-227 (515) alignment
Range on Protein: 83-267
Range on HMM: 45-227/515.0
HKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRP---RYWPS-LGVTETYGC
.|||| ... .|..||||  |. . | ||. | |...     ..|.||||.. .. ||||...||.   | .. |  .. .    .|||   | .  .| 
kknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGs

IRVTNFSESSEEFEICNlAVTFVPDNvpvdeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTvpQRLLAQVR--H----GPCVVHCSAGKDRLYVVC
|.|   | ..    |    .| . ..          .   |   .. .||| ||| .       .|. .|.  |     | ..|||||  |  ||.
ikvelvsleactggikr.kltvlkgd..........dsrtvtqfhfteWPdkGvpkhtssl..lklikevkadhgqythpliihcsaGvGrtGvvi

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 81-267 3.4e-23 77.2 In-house 51-235 (297) alignment
Range on Protein: 81-267
Range on HMM: 51-235/297.0
YMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLrsTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG--RPRYWPSLGVTEtYGC
 ..|.|| ...  | |||||.|  .    ||. | .||.|     .|..| | . |. |||.|...|..  |..| .  ..     |||.  |||. .| 
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvtt.fGd

IRVTNFSESSEEfeicnlavTFVPDNVPVDEQPANLEGLrVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVR-------HGPCVVHCSAGKDRLYVVC
. |.  | |. |         |.  .. | .. |  . . |   .. .|||  |. ..  .  . |. .||       .|| .|||.||  |  |..
vsvvllsvsere........Gfikrelevtkgkakarrv.vkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

subfamily_ptpA1_pd Subfamily ptpA1 57-267 5.6e-23 76.3 In-house 22-247 (418) alignment
Range on Protein: 57-267
Range on HMM: 22-247/418.0
GLVKQYRKLDAKQDPSLTYDAYTKY-MHKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRsTFICSQGPLQHTIIDFWRMIFQERAESILLL
 . ...| |.    || | .   |.   |||| ... .. .||.|| |.     ||| |||.   | .  |||.||||  || |||||....|.  |..|
kikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivml

CKVGREGR---PRYWPSLGVTETYGCIRVTNfsESSEEFEICNLAVTFVPDNVP-VDEQPANLEGL--RVSLIKWPNWPDCGVPDEK------CHTVPQR
 .   . |    ||||     | .      |  |    . .  . |   |.      .    .||    ..  ..  |||  .||         |.. .|
sresencrikcdrywpeqiggeqfsiygngn..evfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnr

----LLAQVRHGPCVVHCSAGKDRLYVVC
    . .  |  | .||||||  |   .|
qnqiipssdrnvpiivhcsagvgrtgtfc

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 71-277 1e-22 75.2 In-house 40-241 (439) alignment
Range on Protein: 71-277
Range on HMM: 40-241/439.0
PSLTYDAYTKymHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRprYWPSL
 ||. . | .   |||| ||. .| .|| | .|    |  || |||.|  |    .| .||| ..|  ||||.......  |. |...    .  |||| 
aslaaqeydq..tknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk..ywpsd

GVTeTYGCIRVTnfseSSEEFEICNLAVTFVpdNVPVDEQPANLEgLRVSLIKWPNWPDCGVPDEKCHTVPQ-RLLA----QVRHGPCVVHCSAGKDRLY
. .  || | |        . |. | ..  .  .|  . . .. |   |  ...  |||  || .  | .   | .     .   || |||||||  |  
aev.cygdiavr....vdrnielpnyvirgf..kvfnerdtteke.rtvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtG

-VVCLDNSRVKLKI
 ...|| .  .||.
tiialdialeqlkl

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 75-270 1.1e-22 75.1 In-house 37-230 (312) alignment
Range on Protein: 75-270
Range on HMM: 37-230/312.0
YDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSlgVTET
  |. |.   ||| .. | |  |  |  |.     |||||.||       |.|.||||. |.  ||.. .   . ||.||| .  .|  .      ... 
ctaflkfkdlnrypniqcwdrgrftlagden...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcaky..isdi

YGCIRVT---NFSESSEEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDeKCHTVpQRLLAQVRH--GPCVVHCSAGKDRLYVVCLD
 | . .     ..|.  | ||   .   .   |      |  .  ..   .|  ||| |.||  | |  .|||. |..   | . |||||  |   ..| 
vgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpd.scdta.lrllsavkkdkkpviahcsagvgrtgtlali

N
.
e

0051299 (Phosphotyrosine protein) phosphatases II 265-331 1.3e-22 76.0 In-house 58-125 (288) alignment
Range on Protein: 265-331
Range on HMM: 58-125/288.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||.  ..  ..|||.|.|... .|  .||. ||||..|. |||||..... . |  |.|
ilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltk

0036941 (Phosphotyrosine protein) phosphatases II 265-331 1.4e-22 75.8 In-house 48-111 (297) alignment
Range on Protein: 265-331
Range on HMM: 48-111/297.0
VVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|..||||   .. . |||.|.||.. .|  .||. ||||..|. |||||..... ..|. |..
ilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlte

0050432 (Phosphotyrosine protein) phosphatases II 265-331 1.5e-22 75.8 In-house 77-141 (308) alignment
Range on Protein: 265-331
Range on HMM: 77-141/308.0
VVCLDNSRVKLkidkSRHGDYIHANYVKTN--YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||    . . |||.|.||..   .|. .||. ||||..|. |||||..... . |  |.|
ilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtk

0046845 (Phosphotyrosine protein) phosphatases II 265-331 2.6e-22 75.0 In-house 37-110 (284) alignment
Range on Protein: 265-331
Range on HMM: 37-110/284.0
VVCLDNSRVKLKIDKS--RHGDYIHANYVKTN-----YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.||||||  ..   ..|||.|.||..      | . .||. ||||..|. |||||....... |  |..
ilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmlte

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 83-263 2.8e-22 74.1 In-house 5-186 (237) alignment
Range on Protein: 83-263
Range on HMM: 5-186/237.0
HKNRYCDVVCLDNSRVKLKIDKSRhGDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKV---GREGRPRYWPSLGVTETYGCI
 |||| ..|. | ||| ||   |   ||| |.|.|  .    ..|..||||. .  |||.|..||.   |..|  .    ..   .||||    ..|| .
iknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygvl

RVTNfsESSEEFEICNLAVTFVPDNVPVDeqpanleGLRV-SLIKWPNWPDCGVPDEKCHTV--PQRLLAQVRH----GPCVVHCSAGKDRL
 |.      |||    .    .  .. .        ..|.    ..  ||| |||.. .  .   .... . .|    || ..|||||  | 
tvsl..kkkeefsdytvrslllskrltlk.......evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrt

subfamily_PTPN14_pd Subfamily PTPN14 62-268 3.8e-22 73.6 In-house 29-248 (300) alignment
Range on Protein: 62-268
Range on HMM: 29-248/300.0
YRKLDAKQDPSLTY-DAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNY--LRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKV-
| ..  |.  .|..  .  .  .|||. ||.  ...||.|.  |  . .|| |  .|.     . ..| .||||..|. |||.|....  . |..| .  
yeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteee

--GREGRPRYWPSLG---VTETYGCIRV-TNFSESSEEFEICNLAVTFVPDNvpvdEQpanlegLRVSLIKWPNWPDCGVPDE---------KCHTVPQR
  |.|   .|.|.|.    | ..|  .| |.|||.|. .    | . ..| .    |.        |  ... .||| |||..         . . | ..
edgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpsk....ee......rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrk

LLAQV----RHGPCVVHCSAGKDRLYVVCL
   .|    .. | .||||||  |  |. |
tnseveskeskPPvlvhCsaGvGrtGvlil

0040438 (Phosphotyrosine protein) phosphatases II 265-331 4.2e-22 74.2 In-house 52-119 (317) alignment
Range on Protein: 265-331
Range on HMM: 52-119/317.0
VVCLDNSRVKLKIDKS-RHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||. ...  . |||.|.||.. .|. .||. ||||..|. |||||..... ..|. |..
ilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLte

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 81-266 4.3e-22 73.1 In-house 45-186 (392) alignment
Range on Protein: 81-266
Range on HMM: 45-186/392.0
YMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVgREGRprywpslgvtetygcir
 ..|||| ... .|..||||  || . . ||. | |...     ..|.||||   .. |||||.|||.. .| .. |. .||                  
nlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtkl.kegd.................

vtnfsesseefeicnlavtfvpdnvpvdeqpaN-LEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHG----PCVVHCSAGKDRLYVV
                                .  .   |.  .. .||| .||   .  .      .. .|    | ..|||||  |  ||
................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvv

Y_phosphatase Protein-tyrosine phosphatase 265-331 5.7e-22 73.6 Pfam-A 10-75 (235) alignment
Range on Protein: 265-331
Range on HMM: 10-75/235.0
VVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|..
ilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmlts

Y_phosphatase Protein-tyrosine phosphatase 265-331 5.7e-22 73.6 In-house 10-75 (235) alignment
Range on Protein: 265-331
Range on HMM: 10-75/235.0
VVCLDNSRVKLKIDKSRHGdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
... |..||||| .....  ||.|||||.    ..||..||||..|| |||||..||. ..| .|..
ilpydktrvklkgsegpsd.YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmlts

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 77-235 1.5e-21 71.5 In-house 29-183 (297) alignment
Range on Protein: 77-235
Range on HMM: 29-183/297.0
AYTKYMHKNRYCDVVCLDNSRVKLKIDKsRHGDYIHANYVKT--NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPR---YWPSL-G
     ..|||| |..  |..||||.       ||| |.||    .     .|..||||. |. |||......    | ...|.  .|| .   ||||  .
krnsslrknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

VTETYGCIRVTNFSESSEEFEICNLavTFVP--DNvpvdeqpanLEGLRVSLIKWPNWPDCGVPDEK
   . | . |   |. |.||.   |  | .               |   |  ... .||| ||| . 
erlkagdvvveflsstsdefdrvil..telqliyr.........sesrvvrhvqflswpdhGvpsdl

0047943 (Phosphotyrosine protein) phosphatases II 265-331 2.3e-21 71.9 In-house 47-110 (273) alignment
Range on Protein: 265-331
Range on HMM: 47-110/273.0
VVCLDNSRVKLkidKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||   .. . |||.|.||.. .|  .||. ||||..|. |||||....... |  |..
ilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLte

0045450 (Phosphotyrosine protein) phosphatases II 265-331 2.8e-21 72.0 In-house 64-140 (307) alignment
Range on Protein: 265-331
Range on HMM: 64-140/307.0
VVCLDNSRVKLKIDKS--RHGDYIHANYV--------KTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|..||||.  ..   ..|||.|.||        .. .|  .||. ||||..|. |||||..... . |. |..
ilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmlte

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 59-155 9.1e-21 68.7 In-house 25-115 (303) alignment
Range on Protein: 59-155
Range on HMM: 25-115/303.0
VKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKiDKSrhgdYIHANYVKTNYLRSTfICSQGPLQHTIIDFWRMIFQERAESILLLC
|... |. .   ||.. . . | |.|||..||.||| |.|||  | |    ||||.|.. .  . . | .| ||.||  |||.|| ...   .||| 
vnefekvvsylppsvsknqfvknmdknrfvdvicldhskvkls.dss....yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvllll

subfamily_CG7180_pd Subfamily CG7180 79-263 1.4e-20 68.1 In-house 40-237 (296) alignment
Range on Protein: 79-263
Range on HMM: 40-237/296.0
TKYMHKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR--PRYWPSLGvTETY
.. . |||. .||  |. || | |.|   . ||| | || .      .|  ..| ..|. .|||....| ....  |.|..   .  | |||  .  | |
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnks.keqy

GCIRVTNFS-ESSEEFEICNLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPD-CGVPDE-----KCHTVPQRLLAQV----RHGPCVVHCSAGKDRL
| | |   . ..  ...| .. .|     .   |.. . |   | |...  |.    ||       .     . .  .|     .|| ||..| |. | 
geifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRs

0043147 (Phosphotyrosine protein) phosphatases II 107-262 3.1e-20 68.1 In-house 4-113 (172) alignment
Range on Protein: 107-262
Range on HMM: 4-113/172.0
HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVgregrprywpslgvtetygcirvtnfsesseefeicnlavtfvpdnvpv
. |||.|.|....|    ||. ||||..|. |||||. ..    |. |..                                                  
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

dEQPANLEGLRVSLIKWPNWPDCGVPdEKCHTVP-----QRLLAQVRHGPCVVHCSAGKDR
 . .. |.   .  . . .||| |||    .        ..|||. ..||..||||||..|
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgR

0039614 (Phosphotyrosine protein) phosphatases II 265-331 4.2e-20 67.8 In-house 65-134 (297) alignment
Range on Protein: 265-331
Range on HMM: 65-134/297.0
VVCLDNSRVKLKIDKS--RHGDYIHANYVKTNYL-RSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.||||||  ..   . |||.|.||.. .|   .||..||||..|. |||||..... ..|. |.|
ilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtk

0043336 (Phosphotyrosine protein) phosphatases II 265-331 4.5e-20 67.7 In-house 54-121 (278) alignment
Range on Protein: 265-331
Range on HMM: 54-121/278.0
VVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||. .... . |||.|.||..     .||..||||..|. |||||..... ..|. |..
ilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLte

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 265-330 1.1e-19 65.3 In-house 57-120 (305) alignment
Range on Protein: 265-330
Range on HMM: 57-120/305.0
VVCLDNSRVKLkiDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
| |||| ||||  . .   .||||||| |      |||.| ||..|  ||| | .|.. |.|..||
vgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlc

0040439 (Phosphotyrosine protein) phosphatases II 265-331 1.9e-19 65.7 In-house 20-87 (249) alignment
Range on Protein: 265-331
Range on HMM: 20-87/249.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|.|||||.| ..  ..|||.|.|... |   .||. ||||..|. |||||..... ..|. |..
ilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLts

0045098 (Phosphotyrosine protein) phosphatases II 265-330 3.9e-19 64.6 In-house 42-96 (278) alignment
Range on Protein: 265-330
Range on HMM: 42-96/278.0
VVCLDNSRVKlkidksrhgDYIHANYVKTNylRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
....|.||||         |||.|.|...   . .||. ||||..|. |||||..... ..|. |.
ilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 264-331 4.6e-19 63.2 In-house 45-114 (281) alignment
Range on Protein: 264-331
Range on HMM: 45-114/281.0
YVVCLDNSRVKLKI--DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
 . ||| |||.||.   .    |||||||... .|.  .| .||| . |  ||||||.|| . .|..||.
nipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcq

0046846 (Phosphotyrosine protein) phosphatases II 106-262 6.9e-19 63.7 In-house 10-122 (176) alignment
Range on Protein: 106-262
Range on HMM: 10-122/176.0
RHGDYIHANYVKTNYlrstFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR---PRYWPSlgvTETYGCirvtnfsesseefeicnlavtfvpd
 . |||.||.. ...    .|. |||| .|. ||..|..... . .. |..    ||   |.|||     |..|.                         
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi.........................

nvpvdeqpanleglrvsLIKWPNWPDCGVPDEK--CHTVPQRLLAQVRHGPCVVHCSAGKDR
                  ... .||| |||| .  .. . .   |. ..|| .||||||. |
.................qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigR

0036282 (Phosphotyrosine protein) phosphatases II 108-267 7.7e-19 63.5 In-house 2-122 (174) alignment
Range on Protein: 108-267
Range on HMM: 2-122/174.0
GDYIHANYVKTNYLRSTFICSQGPLQhtiidFWRMIFQERAESILLLCKVGR---EGRPRYWPSlgvtetygcirvtnfsesseefeicnlavtfvpdnv
 |||.|.... .|  . .|..||||.     ||.|..... .... |..      .. ..|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

pvdeqPANLEGLRVSLIKWPNWPDCGVPDE----KCHTVPQRLLAQVRHGPCVVHCSAGKDRLYVVC
       . .   .  ... .||| ||||     ..    .. |.. ..||..||||||..|  ...
.....lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlv

subfamily_PTPRD_pd Subfamily PTPRD 265-330 8e-19 62.7 In-house 57-123 (564) alignment
Range on Protein: 265-330
Range on HMM: 57-123/564.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.|  |.|||.| |...    ||| |.....   | ..| .||||..|| |||||..... ..| .| 
ivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

subfamily_egg_pd Subfamily egg 264-329 1e-18 62.1 In-house 48-114 (307) alignment
Range on Protein: 264-329
Range on HMM: 48-114/307.0
YVVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
 | | | |||||.. . .. .|.||||.|| . |  .||..| ||. |  |||||.|||. . |..|
rvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 82-262 2.6e-18 60.8 In-house 51-227 (301) alignment
Range on Protein: 82-262
Range on HMM: 51-227/301.0
MHKNRYCDVVCLDNSRVKLKIDKSRHGdyIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSLGvTETYGCIRVT
 .|.||  | |  .. |..  |  |    ||||...|.     ||..||||. |  ||| |. |   | | .|..   .   .    |  ...   ... 
kdkhryptvPckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylp.vkisekldig

NFSESSEEFEICnLAVTFVPDNVPVDEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKDR
 |.   .. |   |    .  .. | .   ...   |   .. .|.| |||  . ..     |..  . | |||||||  |
rfkikiknkeli.lnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksekPivvhcsaGiGr

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 265-330 5e-18 59.8 In-house 65-126 (290) alignment
Range on Protein: 265-330
Range on HMM: 65-126/290.0
VVCLDNSRVKLKidKSRHGDYIHANYVKTnyLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
||| | .|| ||     .|||.||||||   |...|| .||.|. |.||.|||. ||..  | .||
vvcndktrvilk..dGydGdyvhanyvkG..lkamfiltqGalkdtvidiwrmvlqekvaaivmlc

subfamily_PTPRN_pd Subfamily PTPRN 75-266 6.3e-18 59.5 In-house 50-241 (297) alignment
Range on Protein: 75-266
Range on HMM: 50-241/297.0
YDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLR-STFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG---RPRYWPSL
     |...|||. .|.  |.|||||| . |. . ||| |  .  .  | ...| .|||| .|. |||.|.... .  |. |...  ||     ||||  
vakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpde

GvTETYGCIRVTNFSES--SEEFeicnLAVTFVPDNVPVDeqpanlEGLRVSLIKWPNWPDCGVPDEKCHTVPQRL-LA---QVRHGPCVVHCSAGKDRL
| .|.|.   |   ||   ....    |  .|   |.  .      |   |.  ..  ||. ||| .    .  |  .    . |  | |||||.|  | 
G.sevyhiyevhlvsehiwcddy....lvrsfylknlqts......etrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrt

YVV
 | 
Gvy

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 83-262 6.5e-18 59.8 In-house 10-187 (239) alignment
Range on Protein: 83-262
Range on HMM: 10-187/239.0
HKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWPSlgVTETYGC
 ||||...|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|  .    ..   .|||    |  |  
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stskycn

IRVTNfsESSEEFeICNLAVTFVPDNVpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGKDR
.|||     .| |    .  |||  .|       . |   |   ..  ||| |||.     .  |  .  .      | |.|||||  |
lrvtl..rktevf.adyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 83-262 7.6e-18 59.5 In-house 9-186 (239) alignment
Range on Protein: 83-262
Range on HMM: 9-186/239.0
HKNRYCDVVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWPSlgVTETYGC
 ||||...|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|  .    ..   .|||    |  |  
aknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd..stskycn

IRVTNfsESSEEFeICNLAVTFVPDNVpvdeqpANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQR--LLAQVR--HGPCVVHCSAGKDR
.|||     .| |    .  |||  .|       . |   |   ..  ||| |||.     .  |  .  .      | |.|||||  |
lrvtl..rktevf.adyiirtfvmsqv......gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgr

subfamily_PTPRB_pd Subfamily PTPRB 265-330 7.9e-18 59.5 In-house 60-126 (293) alignment
Range on Protein: 265-330
Range on HMM: 60-126/293.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
..  |.||||| ....... ||| |||.. .  .  || .|||| .|. |||||....... |..| 
ilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmlt

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 265-331 8.1e-18 59.5 In-house 50-115 (307) alignment
Range on Protein: 265-331
Range on HMM: 50-115/307.0
VVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
| | |..|. .|.|     |||||||. .      |||.||||. |. .|| |. ||. ||...|||
vkcqdkgrivvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlck

0042113 (Phosphotyrosine protein) phosphatases II 265-331 1.2e-17 59.7 In-house 18-85 (245) alignment
Range on Protein: 265-331
Range on HMM: 18-85/245.0
VVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
....|..||||. |... . |||.|.||.. .   .||..||||..|. |||||..... ..|. |..
ilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLte

subfamily_PTPN12_pd Subfamily PTPN12 265-331 2.1e-17 57.9 In-house 49-116 (290) alignment
Range on Protein: 265-331
Range on HMM: 49-116/290.0
VVCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
..  |.|||.|. ... .  ||| ||..|  . . ..| .|||| .|. ||||||.. . | ....|.
ilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCr

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 266-331 4.5e-17 57.2 In-house 56-122 (305) alignment
Range on Protein: 266-331
Range on HMM: 56-122/305.0
VCLDNSRVKLKIDKSRH-GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
. ||..|..|. ..| .  ||| |.||..   . ..| .||||..|. ||||.|..|. ..|..|.|
tlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltk

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 265-329 5.9e-17 56.7 In-house 18-83 (250) alignment
Range on Protein: 265-329
Range on HMM: 18-83/250.0
VVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.. ||.||| |. .|  .. ||| | ....   |..|| .|||||.|| |||||...| ...|..|
iialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmL

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 265-331 9.7e-17 55.5 In-house 64-129 (305) alignment
Range on Protein: 265-331
Range on HMM: 64-129/305.0
VVCLDNSRVKlkIDKSRHGDYIHANYVKTNYLR-STFICSQGPLQHTIIDFWRMIFQERAESILLLCK
| | |.| ||  .||    ||||||||    .    |||.||||..|| .|| |. |.. | |..|||
vpcqdqsavk..ldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlck

subfamily_PTPN9_pd Subfamily PTPN9 265-329 1.2e-16 55.6 In-house 51-116 (297) alignment
Range on Protein: 265-329
Range on HMM: 51-116/297.0
VVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|.|.|..||.|. .|.  . |||.||.|     . .||  ||||..|. |||||......  |.. 
vlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmt

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 265-329 1.4e-16 55.7 In-house 65-130 (298) alignment
Range on Protein: 265-329
Range on HMM: 65-130/298.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.. || ||| |.  |.  ..||| | ....   |..|| .|.||..|. |||||. .| ...| .|
iialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVml

0051082 (Phosphotyrosine protein) phosphatases II 108-262 3.8e-16 54.5 In-house 3-105 (151) alignment
Range on Protein: 108-262
Range on HMM: 3-105/151.0
GDYIHANYVKTNylrstFICSQGPLQhtiiDFWRMIFQERAESILLLCKVG-REGRPRYWPSLGvtetygcirvtnfsesseefeicnlavtfvpdnvpv
 |||...||  .     ...|.|||.    ||.... ..   .|. |..   |.  |.|.|.||                                    
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg....................................

deqpanlegLRVSLIKWPNWPDCGVPD--EKCHTVPQRLLAqVRHGPCVVHCSAGKDR
         ..|  | ...||| |.|.  . .  . . ||.  ..||..|||||||.|
.........ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgR

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 265-330 5e-16 53.6 In-house 55-121 (318) alignment
Range on Protein: 265-330
Range on HMM: 55-121/318.0
VVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
..  |..||||.  . .   ||| |||.  .  . ..| .|.|| .|| |||||...  .  |..| 
ilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmlt

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 81-205 7e-16 52.9 In-house 47-187 (350) alignment
Range on Protein: 81-205
Range on HMM: 47-187/350.0
YMHKNRYCDVVCLDNSRVKLK--------IDKSR-HGDYIHANYVKTN----YLRSTF--ICSQGPLQHTIIDFWRMIFQERAESILLLCK---VGREGR
 . |||| ...  . ||||||        ...|    ||| |||.| .       . |  |  |.||. |. ||...|..   . || | .    ..|  
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

PRYWPSLGVTETygCIRVTNFSESSEEFEICNLAVTFVPDNVP
 |||. ... .    .....  |.  . . . | .. |  . .
yrYWqegsyddi..tvklaskwenimgindsslysadvkkeas

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 265-329 7.1e-16 53.1 In-house 56-121 (288) alignment
Range on Protein: 265-329
Range on HMM: 56-121/288.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.. .|  |||||  .. .  ||| |.|.. .  . ..|..||||..|. |||......... |. |
ilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivml

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 268-330 8.9e-16 52.8 In-house 40-105 (274) alignment
Range on Protein: 268-330
Range on HMM: 40-105/274.0
LDNSRVKLKIDKSRH--GDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 .|||| |. ..|..   .|| |||.|  ..   ...  ||||..|. ||||||.||... |..| 
nensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmlt

0049260 (Phosphotyrosine protein) phosphatases II 118-262 9.2e-16 53.4 In-house 4-102 (152) alignment
Range on Protein: 118-262
Range on HMM: 4-102/152.0
TNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVG---REGRPRYWpslgvtetygcirvtnfsesseefeicnlavtfvpdnvpvdeqpanle
  .    ||. |||. .|. |||||. .  .  |. |..     ... ..|.                                                
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................

glrvsLIKWPNWPDCGVPDEKCHTVPQRLL----AQVRHGPCVVHCSAGKDR
      ... .||| ||||   .     |.    |. ..||..||||||..|
.....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgR

subfamily_PTPRG_pd Subfamily PTPRG 264-329 1.6e-15 51.3 In-house 55-122 (563) alignment
Range on Protein: 264-329
Range on HMM: 55-122/563.0
YVVCLDNSRVKLKIDKSRHG--DYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
 .|  |.|||||.     ..  ||| |||..  .    || .||||..|. ||||||...... | ..
nivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmi

subfamily_Ptp69D_pd Subfamily Ptp69D 266-329 1.7e-15 52.0 In-house 58-122 (307) alignment
Range on Protein: 266-329
Range on HMM: 58-122/307.0
VCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.  |. ||||| |  . . ||| |...|.   . .||..|.|.. || |||||| .   . | .|
kafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivml

subfamily_PTPRK_pd Subfamily PTPRK 265-329 2.1e-15 51.4 In-house 52-117 (314) alignment
Range on Protein: 265-329
Range on HMM: 52-117/314.0
VVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
..  |.|||.|. ||   . ||| |... .    . ||  |||||.|. ||||....|.. ||..|
ilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivml

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 80-199 2.3e-15 51.3 In-house 32-150 (267) alignment
Range on Protein: 80-199
Range on HMM: 32-150/267.0
KYMHKNRYCDVVCLDNSRVKLKIDKSRhgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSL-GVTETYGCI
|   .||. |..  |..|| |.  .     || | ||.. . . .||  |.||. || ||. .| ...   | || ||. .  ...||   | .. |  .
knqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvftdnirlfwPPkmgqakkyqdl

RVTNFSESSE-EFEICNLAVTF
 |    |  | ...|  | . |
tvehslekeendyqiitlelkf

subfamily_PTPN6_pd Subfamily PTPN6 265-328 2.4e-15 51.3 In-house 63-128 (306) alignment
Range on Protein: 265-328
Range on HMM: 63-128/306.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNYL--RSTFICSQGPLQHTIIDFWRMIFQERAESILL
..  |..||.|| ..    ||| |||.|..    . ..| .|| |..|. |||||..|| .. |..
ilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivm

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 260-331 4.4e-15 50.5 In-house 51-124 (319) alignment
Range on Protein: 260-331
Range on HMM: 51-124/319.0
KDRLY-VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
|.|   ..  |..||.| ..| .   ||| |... .   |. ||  |.||..|| |||||...|..  ...|.|
knryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltk

0037934 (Phosphotyrosine protein) phosphatases II 265-331 5.8e-15 51.0 In-house 19-81 (243) alignment
Range on Protein: 265-331
Range on HMM: 19-81/243.0
VVCLDNSRVKLkidksRHGDYIHANYVKTNylrSTFICSQGPLQHTIID----FWRMIFQERAESILLLCK
....|.|||||       .|||.||...      ..|..||||..|. |    ||||..... ..|. |..
ilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmlte

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 265-329 7.7e-15 49.7 In-house 50-115 (281) alignment
Range on Protein: 265-329
Range on HMM: 50-115/281.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|  |..|||. . ... . ||| ||.|..      .| .|||. ... .||.|....... | ..
ivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmv

subfamily_ptpA1_pd Subfamily ptpA1 265-330 1.1e-14 49.0 In-house 56-121 (418) alignment
Range on Protein: 265-330
Range on HMM: 56-121/418.0
VVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRsTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.. .. .||.|| |.     ||| |||.   | .  |||.||||  || |||||....|.  |..| 
ilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmls

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 264-330 1.7e-14 49.0 In-house 33-100 (284) alignment
Range on Protein: 264-330
Range on HMM: 33-100/284.0
YVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 ..  |...|||. ..     ||| | ...    .  .| .||||. |. ||||||.. .. .|.|| 
hilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 264-330 1.7e-14 48.9 In-house 69-136 (319) alignment
Range on Protein: 264-330
Range on HMM: 69-136/319.0
YVVCLDNSRVKLK-IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 ..  |...|||. ..     ||| | .|.    .  .| .||||. |. ||||||.. .. .|.|| 
nilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 267-330 1.9e-14 48.2 In-house 55-119 (315) alignment
Range on Protein: 267-330
Range on HMM: 55-119/315.0
CLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 ||..||||  ||.| . ||| | |.|.     ..|.|||||. .. |||||..||.. .| .. 
PldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

subfamily_CG42327_pd Subfamily CG42327 83-236 2.1e-14 47.9 In-house 30-181 (319) alignment
Range on Protein: 83-236
Range on HMM: 30-181/319.0
HKNRYCDVVCLDNSRVKLK-IDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREG---RPRYWPS---LGVTET
 |.|. .|| | ..|| |. | .  .  |..|.||.     .. .|..| .|. .  ||||.... ..  |. |...   |    ..|.|.   |  |..
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YGCIRVTN-FSESSEEFEICNLAVTfvpdNVPVDEQpanleglRVSLIKWPNWPDCGVPDEKC
|| |.||    |. ... |  | .     .|  .|        |     | .|....|| |. 
yGdilvtlkgrevkdryaistlllk....rvdkees.......relthywykwleaevPaeea

subfamily_PTPRA_pd Subfamily PTPRA 265-330 3.6e-14 47.4 In-house 67-133 (330) alignment
Range on Protein: 265-330
Range on HMM: 67-133/330.0
VVCLDNSRVKLKI-DKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
..  | ||| |   .   . ||| | ...    . .|| .|||...|. ||||||.. .. .|..| 
ilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlt

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 265-331 3.7e-14 47.4 In-house 56-119 (287) alignment
Range on Protein: 265-331
Range on HMM: 56-119/287.0
VVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
..  || || ||    .| ||| | ....   .  || ...|. .|. .||..| ... . |..||.
ilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcq

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 265-329 5e-14 46.7 In-house 47-111 (287) alignment
Range on Protein: 265-329
Range on HMM: 47-111/287.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|. .|..|| |  .     ||| |||| .     .||..|||.  |. ||||.....|. |....
vlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitm

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 266-330 5.8e-14 46.3 In-house 55-120 (392) alignment
Range on Protein: 266-330
Range on HMM: 55-120/392.0
VCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
. .|..||||  || . . ||. | |...     ..|.||||   .. |||||.|||.. .| .. 
lpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 267-330 6e-14 46.0 In-house 54-118 (515) alignment
Range on Protein: 267-330
Range on HMM: 54-118/515.0
CLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 .|..||||  |. . | ||. | |...     ..|.||||.. .. ||||...||.   | .. 
PydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvt

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 265-331 6.4e-14 46.5 In-house 55-124 (290) alignment
Range on Protein: 265-331
Range on HMM: 55-124/290.0
VVCLDNSRVKLKiDKSRHGD----YIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.|  |. |. |. ..| | |    ||.| |.|    .  .|  |||...|..|||..| ||.   |..|..
ivvyddnritLr.pisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltn

subfamily_PTPN23_pd Subfamily PTPN23 266-330 7.7e-14 46.2 In-house 53-115 (288) alignment
Range on Protein: 266-330
Range on HMM: 53-115/288.0
VCLDNSRVKLKidkSRHGDYIHANYVKTNYLRS-TFICSQGPLQHTIIDFWRMIFQERAESILLLC
.  |..||||.   . . ||| | .||     . .||..|.||| |. |||.|....... | .| 
lPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmll

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 265-329 1e-13 46.2 In-house 57-122 (325) alignment
Range on Protein: 265-329
Range on HMM: 57-122/325.0
VVCLDNSRVKLKIDK-SRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|| ||.||| |.  | . . ||| |.|....  . .|. .| || .|| |.||.... |.  ...|
vvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 265-331 1.3e-13 45.5 In-house 42-108 (283) alignment
Range on Protein: 265-331
Range on HMM: 42-108/283.0
VVCLDNSRVKLKIDKSrhgDYIHANYVK--TNY-LRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.|  |. ||.|| .     ||| | ..    .|     .| .|.||..|..|||.|.|.|.. .|..| |
ivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltk

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 279-330 1.3e-13 45.4 In-house 66-117 (301) alignment
Range on Protein: 279-330
Range on HMM: 66-117/301.0
KSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.. . .|| |.|..    .  || .|||...|..||||.|.||.  ||. ..
dlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvt

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 265-329 2e-13 45.0 In-house 58-123 (315) alignment
Range on Protein: 265-329
Range on HMM: 58-123/315.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
..  |.|||.|  ...  | ||. ||...    .  .|..|||.  .. ||||..|.|    |..|
iiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivml

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 265-330 3.6e-13 44.1 In-house 44-107 (285) alignment
Range on Protein: 265-330
Range on HMM: 44-107/285.0
VVCLDNSRVKLKidkSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
| |....|| ||    .  |||||....     .||.| .||||  |. |||.||.||.   .|.||
vrcieetrvvlk...nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlc

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 268-329 5.1e-13 43.8 In-house 63-123 (297) alignment
Range on Protein: 268-329
Range on HMM: 63-123/297.0
LDNSRVKLKIDKSR-HGDYIHANYVKTNYLrsTFICSQGPLQHTIIDFWRMIFQERAESILLL
 | |||||.|  .    ||. | .||.|     .|..| | . |. |||.|...|..  |..|
ydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivml

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 270-329 5.9e-13 43.4 In-house 34-95 (270) alignment
Range on Protein: 270-329
Range on HMM: 34-95/270.0
NSRVKL-KIDKSRHGDYIHANYVK-TNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
..||.| ....  .  || ||||.  .  . ..|...|||. |. .|||||..|....|...
atRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmt

subfamily_PTPN1_pd Subfamily PTPN1 266-330 6.7e-13 43.0 In-house 42-103 (290) alignment
Range on Protein: 266-330
Range on HMM: 42-103/290.0
VCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
   | ||.||. ..    ||| |. |. . ..  .| .|||| .|.  ||.|...... ....| 
spydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmln

subfamily_PTPN3_pd Subfamily PTPN3 266-329 7.1e-13 43.1 In-house 51-115 (280) alignment
Range on Protein: 266-329
Range on HMM: 51-115/280.0
VCLDNSRVKLKidKSRHgDYIHANYVKTNYLR----STFICSQGPLQHTIIDFWRMIFQERAESILLL
.  |. |||||  .|.  ||| ||||. .         .| .||||..|  |||.|....... |..|
lpydatrvklk..eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivml

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 264-329 1.8e-12 41.5 In-house 55-114 (303) alignment
Range on Protein: 264-329
Range on HMM: 55-114/303.0
YVVCLDNSRVKLKiDKSrhgdYIHANYVKTNYLRSTfICSQGPLQHTIIDFWRMIFQERAESILLL
 |.||| |.|||  | |    ||||.|.. .  . . | .| ||.||  |||.|| ...   .|||
dvicldhskvkls.dss....yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlll

0044763 (Phosphotyrosine protein) phosphatases II 106-262 3.9e-12 41.7 In-house 16-123 (178) alignment
Range on Protein: 106-262
Range on HMM: 16-123/178.0
RHGDYIHANYVKTNylrsTFICSQGPlqhtiIDFWRMIFQERAESILLLCKVGREGR---PRYWPSLGVtetygcirvtnfsesseefeicnlavtfvpd
  .|||.|...  .     ...|..|      |..... ..   .|. |..  . |.   ..|||.                                  
ersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............................

nvpvdeqpanleglrvSLIKWPNWPDCGVPDEKCHTVPQRLLA---Q-VRHGPCVVHCSAGKDR
                   .. ..|| ||||   |.     .    .  ..||..||||||..|
................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgR

0041856 (Phosphotyrosine protein) phosphatases II 276-330 8.4e-12 40.5 In-house 12-66 (182) alignment
Range on Protein: 276-330
Range on HMM: 12-66/182.0
KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
 .| ||. |||.||..  ..  ..||. ||||..|. ||.||. ...  .|. |.
pydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 265-331 1.3e-11 39.1 In-house 52-115 (288) alignment
Range on Protein: 265-331
Range on HMM: 52-115/288.0
VVCLDNSRVKLKiDKSRHgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
. . | .||||. | .    ||.|| | ..  .  .||.| ||. ||  .|.|....  | |..||.
lprcditrvkls.ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlce

0049772 (Phosphotyrosine protein) phosphatases II 265-320 1.7e-11 39.9 In-house 55-116 (314) alignment
Range on Protein: 265-320
Range on HMM: 55-116/314.0
VVCLDnSRVKLKIDKSRHGDYIHANYVKTNylrSTFICSQGPLQHTIIDF----------WRMIFQ
... | .||.|.    .  |||.|.||..     .||..||||..|..||          |||...
ilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr

subfamily_CG7180_pd Subfamily CG7180 265-331 2e-11 38.1 In-house 51-118 (296) alignment
Range on Protein: 265-331
Range on HMM: 51-118/296.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
||  |. || | |.|   . ||| | || .      .|  ..| ..|. .|||....| ....  |.|
vvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 82-261 2.4e-11 38.3 In-house 19-203 (290) alignment
Range on Protein: 82-261
Range on HMM: 19-203/290.0
MHKNRYCDVVCLDNSRVKLKIDKSRH-GDYIHANYVKT-NYLRstFICSQGPLQHT-------IIDFWRMIFQERAESILLLCKVGREGRP-------RY
 ....  .|  . ..|| ||  ..|   ||||||.|.  | ||  .| .| |....       | .|| |. ||.....  ||..  . .        .|
hemdqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakY

WPS-LGVTETYGCIRVTNF-SESSEEFEICNLAVTFvpdnvpvD-EQPanlegLRVSLIKWPNWPDCGVPDEKCHTVPQRLLAQVRHGPCVVHCSAGKD
 |   |   ... . |     |  ...|. .| |.|       | |..     . |   .  .| .. |....   .      . .. | .|||  |  
vpesvgeelkfkgltvkCkskekeddvetRelvvkf.......ddeee.....ftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiS

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 67-176 3.1e-11 37.3 In-house 81-188 (244) alignment
Range on Protein: 67-176
Range on HMM: 81-188/244.0
AKQDPSLTYDAYTK-YMHKNRYCDVVCLDNSRVKLKiDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGrpRY
 . |||.  ||.     .|||    . .| .|| |    |    || | .|      . .| .| ||  | .|||.|...   . ...|  |  |    |
irpdpsvmkdafnpnnswknregaglpfdfnrvpls.kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed..ey

WPSLGVTETYG
||     | | 
wpdseplewye

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 73-156 3.9e-11 37.0 In-house 26-109 (332) alignment
Range on Protein: 73-156
Range on HMM: 26-109/332.0
LTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPL-QHTIIDFWRMIFQERAESILLLCK
 ||| . . |  ||   . |.| |||.|  .   . |.  |..|     .|..| .| |. .||   ||||. . .   ||..  
ntydkflnnmdmnriphlycfdhsrvelapqdg.kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 53-182 5.1e-11 36.5 In-house 23-155 (302) alignment
Range on Protein: 53-182
Range on HMM: 23-155/302.0
LGIDGLVKQYRKLDAKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKsrhGDYIHANYVKTNYLRSTFICSQGPLQHTI---IDFWRMIFQERAE
|    . |.. |.|. . .     |. | ..||.  || .||. .|||.  .    .|..|  |.   |. . | .| | . .     .||||.|||.  
ldtaevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkleaep...dsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

SILLLCKVGREGR--PRYWP-SLGVTETYGCIRVTN
|. .| .     .    ..|   |  ..|| ..| |
svvilvgeeelkktlselfpkksgdykeygkmfvNn

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 265-330 5.1e-11 36.7 In-house 57-123 (439) alignment
Range on Protein: 265-330
Range on HMM: 57-123/439.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
|. .| .|| | .|    |  || |||.|  |    .| .||| ..|  ||||.......  |. |.
vgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmlt

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 265-329 7.3e-11 36.7 In-house 12-76 (237) alignment
Range on Protein: 265-329
Range on HMM: 12-76/237.0
VVCLDNSRVKLKIDKSRhGDYIHANYVKT-NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|. | ||| ||   |   ||| |.|.|  .    ..|..||||. .  |||.|..||.   |..|
ivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivml

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 270-331 8.5e-11 36.1 In-house 64-123 (301) alignment
Range on Protein: 270-331
Range on HMM: 64-123/301.0
NSRVKLKIDKSRHgdYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
.. |..  |  |    ||||...|.     ||..||||. |  ||| |. |   | | .|..
stavevivdGkrv..PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgq

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 266-329 1.4e-10 35.5 In-house 43-107 (297) alignment
Range on Protein: 266-329
Range on HMM: 43-107/297.0
VCLDNSRVKLKIDKsRHGDYIHANYVKT--NYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.  |..||||.       ||| |.||    .     .|..||||. |. |||......    | ..
latddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmv

subfamily_PTPN14_pd Subfamily PTPN14 265-329 2e-10 35.2 In-house 58-124 (300) alignment
Range on Protein: 265-329
Range on HMM: 58-124/300.0
VVCLDNSRVKLKIDKSRHGDYIHANYVKTNY--LRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
|.  ...||.|.  |  . .|| |  .|.     . ..| .||||..|. |||.|....  . |..|
vlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

0043147 (Phosphotyrosine protein) phosphatases II 282-331 3e-10 35.6 In-house 4-53 (172) alignment
Range on Protein: 282-331
Range on HMM: 4-53/172.0
HGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK
. |||.|.|....|    ||. ||||..|. |||||. ..    |. |..
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnlte

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 67-150 3.3e-10 34.0 In-house 23-112 (347) alignment
Range on Protein: 67-150
Range on HMM: 23-112/347.0
AKQDPSLTYDAYTKYMHKNRYCDVVCLDNSRVKLKIDKSRHG------DYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAES
.   . .|.  . | . |||  ||   |..|| |  .||. .       || | ..| .  .  .| .| || .|. |||.|..  .   
nyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtq

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 260-330 6.8e-10 33.6 In-house 22-99 (290) alignment
Range on Protein: 260-330
Range on HMM: 22-99/290.0
KDRLYVVCLDNSRVKLKIDKSRH-GDYIHANYVKT-NYLRstFICSQGPLQHT-------IIDFWRMIFQERAESILLLC
. || |  . ..|| ||  ..|   ||||||.|.  | ||  .| .| |....       | .|| |. ||.....  ||
dqRlevpLveatrvvLkgygkrfnddyiHAnrvtcpnglr..liltqsPqekitekrnStiekfwwmakqEkvkqvVmlc

subfamily_PTPN13_pd Subfamily PTPN13 265-329 7.8e-10 33.5 In-house 46-108 (273) alignment
Range on Protein: 265-329
Range on HMM: 46-108/273.0
VVCLDNSRVKLKIDKSrhgdYIHANYVKTNYLRST--FICSQGPLQHTIIDFWRMIFQERAESILLL
|.  |..||||. . .    || |...| .    .  .| .|||| .|. |||.|... .|| | ..
vlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 265-330 1.5e-09 32.0 In-house 52-114 (312) alignment
Range on Protein: 265-330
Range on HMM: 52-114/312.0
VVCLDNSRVKLKIDKSrhgDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
. | |  |  |  |.     |||||.||       |.|.||||. |.  ||.. .   . ||.|||
iqcwdrgrftlagden...fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 265-329 1.7e-09 32.2 In-house 17-83 (239) alignment
Range on Protein: 265-329
Range on HMM: 17-83/239.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|
ivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 265-329 1.7e-09 32.2 In-house 16-82 (239) alignment
Range on Protein: 265-329
Range on HMM: 16-82/239.0
VVCLDNSRVKL-KIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLL
.|  | ||| | |. .  | ||| |.|..       ..|..|| .. .  |||||..|||   |..|
ivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivml

subfamily_PTPRN_pd Subfamily PTPRN 261-330 2e-09 31.6 In-house 60-132 (297) alignment
Range on Protein: 261-330
Range on HMM: 60-132/297.0
DR-LYVVCLDNSRVKLKIDKSR-HGDYIHANYVKTNYLR-STFICSQGPLQHTIIDFWRMIFQERAESILLLC
.|   |.  |.|||||| . |. . ||| |  .  .  | ...| .|||| .|. |||.|.... .  |. |.
nrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 264-330 2.4e-09 31.6 In-house 41-104 (267) alignment
Range on Protein: 264-330
Range on HMM: 41-104/267.0
YVVCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
...  |..|| |.    .  .|| | ||.. . . .||  |.||. || ||. .| ...   | || 
dnlpyddtrvilr...tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 82-205 1.4e-08 28.4 In-house 49-190 (349) alignment
Range on Protein: 82-205
Range on HMM: 49-190/349.0
MHKNRYCDVVCLDNSRVKLKID---------------KSRHGDYIHANYVKTNYLR--STFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGR--
. |||| |..  . ||||||                  ..  ||| |||.|   .     .|. | ||  |. ||...|  .. . .| | .   ..   
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

-PRYWPSLGVTETygCIRVTNFSESSEEFEICNLAVTFVPDNVP
  .||  |  ..    ... | |. . . . . | |  | |. .
cdiywqelsysni..tvklqnsslyianvqGnslrvstvkdtdn

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 270-329 2.8e-08 27.9 In-house 61-135 (350) alignment
Range on Protein: 270-329
Range on HMM: 61-135/350.0
NSRVKLK--------IDKS-RHGDYIHANYVKTN----YLRSTF--ICSQGPLQHTIIDFWRMIFQERAESILLL
 ||||||        ...| .  ||| |||.| .       . |  |  |.||. |. ||...|..   . || |
hsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsl

0046846 (Phosphotyrosine protein) phosphatases II 280-330 6.2e-08 28.1 In-house 9-55 (176) alignment
Range on Protein: 280-330
Range on HMM: 9-55/176.0
SRHGDYIHANYVKTNYlrstFICSQGPLQHTIIDFWRMIFQERAESILLLC
  . |||.||.. ...    .|. |||| .|. ||..|..... . .. |.
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlt

0051429 (Phosphotyrosine protein) phosphatases II 283-330 8.2e-08 27.7 In-house 4-53 (272) alignment
Range on Protein: 283-330
Range on HMM: 4-53/272.0
GDYIHANYVKTNYL---RSTFICSQGPLQHTIIDFWRMiFQERAESILLLC
..||.|..|....    . ....|.|||..|. ||||.  ...  .|. |.
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLr

PTPc_DSPc_SM00012 218-267 8.8e-08 27.7 In-house 2-57 (105) alignment
Range on Protein: 218-267
Range on HMM: 2-57/105.0
VSLIKWPNWPDCGVPDEKchTVPQRLLAQVRH--------GPCVVHCSAGKDRLYVVC
|. .....|||.|||.|   .   .||..|..        .|.||||||| .|  ...
vkhyhytgwpdhgvPees..dsilellravkknknksesskpvvVhCsaGvgRtgtfv

0036282 (Phosphotyrosine protein) phosphatases II 283-331 1.4e-07 26.9 In-house 2-45 (174) alignment
Range on Protein: 283-331
Range on HMM: 2-45/174.0
GDYIHANYVKTNYLRSTFICSQGPLQhtiidFWRMIFQERAESILLLCK
 |||.|.... .|  . .|..||||.     ||.|..... .... |..
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 123-182 2.1e-07 24.6 In-house 236-295 (440) alignment
Range on Protein: 123-182
Range on HMM: 236-295/440.0
STFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREGRPRYWPSLGVTETYGCIRVTN
 .||..| ||. |..||||.. . |  .|..| ..       |||    . |.| . |  
nafiatqmpldstvldfwrlvhdyristiimlnqlndktcsiywpvntrsvtfgpftvgh

0048179 (Phosphotyrosine protein) phosphatases II 186-262 2.6e-07 26.0 In-house 19-96 (144) alignment
Range on Protein: 186-262
Range on HMM: 19-96/144.0
SSEEFEICNLAVTFVPDNVPvdEQPANLEGLRVSLIKWPNWPDCGVPDEKCHTVPQ-----RLLAqvRHGPCVVHCSAGKDR
...  ....| .| | . ..  | . . ..  .  . . .||| ||||   .         ..|.  ..||..||||||..|
aldlellkklgittvinlte..eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgR

0048076 (Phosphotyrosine protein) phosphatases II 181-262 3.3e-07 25.6 In-house 14-94 (145) alignment
Range on Protein: 181-262
Range on HMM: 14-94/145.0
TNFSESSEEFEICNLAVTFVPDNvPVDEQPANlegLRVSLIKWPNWPDCGVPDE--KCHTVPQRLLAQV-RHGPCVVHCSAGKDR
 ..   ..  ....| .| | .    ...        .  . . .|||.||||      .. . . . . ..||..||||||..|
gslptaldlellkdlgittvlnl.tselelle...rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgR

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 102-192 5.7e-07 23.9 In-house 7-94 (130) alignment
Range on Protein: 102-192
Range on HMM: 7-94/130.0
IDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCKVGREgrPRYWPSLGVTETYGCiRVTNFSESSEEFEI
... .  .||.|..|      . .. .| ||  | .|||.|...   . ...|  |  |    |||     | |   ...  .   .||. 
vsrlqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee..deywpdsePlewyee.diivtltdrdefkn

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 264-328 9.7e-07 22.6 In-house 42-105 (332) alignment
Range on Protein: 264-328
Range on HMM: 42-105/332.0
YVVCLDNSRVKLKIDKSrHGDYIHANYVKTNYLRSTFICSQGPL-QHTIIDFWRMIFqERAESILL
.. |.| |||.|  .   . |.  |..|     .|..| .| |. .||   ||||.  ||  |..|
hlycfdhsrvelapqdg.kddfynaswvdgyskksayifaqapfndhteyvfwrmvs.erkpsmil

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 266-329 1.6e-06 21.7 In-house 61-124 (302) alignment
Range on Protein: 266-329
Range on HMM: 61-124/302.0
VCLDNSRVKLKidkSRHGDYIHANYVKTNYLRSTFICSQGPLQHTI---IDFWRMIFQERAESILLL
 .||. .|||.    .  .|..|  |.   |. . | .| | . .     .||||.|||.  |. .|
pildsnlvkle...aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvil

subfamily_CG42327_pd Subfamily CG42327 271-330 2.1e-06 21.7 In-house 43-104 (319) alignment
Range on Protein: 271-330
Range on HMM: 43-104/319.0
SRV-KLKIDKSRHGDYIHANYVKTN-YLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLC
.||   .| .  .  |..|.||.     .. .|..| .|. .  ||||.... ..  |. |.
trvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 279-329 2.2e-06 21.2 In-house 86-138 (349) alignment
Range on Protein: 279-329
Range on HMM: 86-138/349.0
KSRHGDYIHANYVKTNYLR--STFICSQGPLQHTIIDFWRMIFQERAESILLL
 ..  ||| |||.|   .     .|. | ||  |. ||...|  .. . .| |
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsL

subfamily_eak_pd Subfamily eak 63-181 2.3e-06 21.3 In-house 33-155 (332) alignment
Range on Protein: 63-181
Range on HMM: 33-155/332.0
RKLDAKQD-PSLTYDAYTKYMHKNrYCDVVCLDNSRVKLKIDKSRHGDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERAESILLLCK---VG
 .|| .|   | .  | .. ...|   ..|  |   |.|   .  .  || |  .. . .   .| .  . .  .  ||.|...... .|. | .    .
adlddyqrllsisetarleavnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

REGRPRYWPSLG-VTETYGCIRVT
 |   .|.|  .     .| . |.
leksdkyfpdktreelkfGildve

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 269-323 3.2e-06 20.9 In-house 50-110 (347) alignment
Range on Protein: 269-323
Range on HMM: 50-110/347.0
DNSRVKLKIDKSRH------GDYIHANYVKTNYLRSTFICSQGPLQHTIIDFWRMIFQERA
|..|| |  .||.         || | ..| .  .  .| .| || .|. |||.|..  . 
datrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkv