Gene Y39B6A.18 in Caenorhabditis elegans

Synonym: CELE_Y39B6A.18, CELE_Y39B6A.18

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP214_AA protein Get Run
CeleP214_AA_1009-1291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1008-1306 1.1e-179 590.6 In-house 2-300 (301) alignment 
Range on Protein: 1008-1306
Range on HMM: 2-300/301.0
KVKKVELWTMSLPNKDDHKPAKFYNTTIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGKRAPIHANWVPTPGHPHRFIATQSPINA
||||.|.|..| ..|||.|.|||||||||||||||||||||||||||||.||||||||||||||||||||||||.||||||.||.||||||||||.|...
kvkkiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkn

TCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHV
|.||||||..||.||.|||.|.|||........|||......|..|||.||..|...|..|.|..|...|.|||||||.||.||||||.|..|||||||.
tsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPksha

ETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTLGTMYRLIKEYGFDMKIYDQQMAMFN
|...|||.|||||||||||||.|||||.||||||||||.||||||||||||||||.||||||||||||||||||||.||||||||||||||..|.|||.
elfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeqlamfd
0036941 (Phosphotyrosine protein) phosphatases II 1058-1306 3.7e-62 205.6 In-house 41-295 (297) alignment 
Range on Protein: 1058-1306
Range on HMM: 41-295/297.0
DKHRYPTVPCKPSTAVEViVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMI
.|.||. ... ..| | .  |..   |.|..|........||||| | . |.|||| |.... |..|||. . ||....    | |.. .. |..|.|..
eknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftv

KMTNMDFIVQKNIMRRSFKVADStGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIGTEYLARQVE---
...... .  ... .| ..| |  |.   ||.||..|  | . ||| |. .  ...|.|.|      |..|..||||.|.|||..||. ... .|.|   
tllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledkl

ADPTIELTEALKHLHEHRWNGVQTNSQLYWMtLGTMYRLIKEYGFDMKIYDQQMAMFN
  ... . ||.|.| |.|.. ||| .|....   ... |.| . ... .... .....
keggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepllklvlllls
0040438 (Phosphotyrosine protein) phosphatases II 1032-1292 1.6e-60 200.4 In-house 19-276 (317) alignment 
Range on Protein: 1032-1292
Range on HMM: 19-276/317.0
NTTIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK---RAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVG
    |  .. ....|...... .   ||.||| ... ... | . ..|.      |.|..|..| ....|||||.| . |.|||| |.... |..|||. 
alleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLt

RKVEYWKNIHNDYLPMwpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADStGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIV
. .|....    | |.  .. |..|.|........    ..|  | ..| |. |.   ||.||..|  | . |||.|. .  ...|.|...    ..|..
eleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvl

VHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMtlgtmYRLIKEYG
||||.|.||...||. ... .|.|   .. ..||.|.| |.|...||| .|....     |... || 
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl.....ydalleyl
0045450 (Phosphotyrosine protein) phosphatases II 1005-1278 4.8e-59 195.9 In-house 7-295 (307) alignment 
Range on Protein: 1005-1278
Range on HMM: 7-295/307.0
KLLKVKKVELWTMSLPNKDDHKPAKFYNttiENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK----RAPIHANWV--------PTP
......| .|. . |. .. .. .| ..   . ..||... ....... .   ||.||. ... ..| | . . ..       |.|..|        ...
lfidalkllllvllllldfltgllkefe...kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAARTLTHY
 ....|||||.| . |.|||| |. .. |..|||. . ||.....   | |   .  |. |.| .......   .... .| ..| |. |..  ||.||.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthf

QYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPT---IELTEALKHLHEHRWNGVQTNSQLYW
.|  | . |||.|  |. ...|.|.|      ...|..|||| |.||...||.  .. ||.|...|   . | ||.|.| |.|...||. .|...
hytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf
0050432 (Phosphotyrosine protein) phosphatases II 1045-1279 2.2e-56 186.8 In-house 57-291 (308) alignment 
Range on Protein: 1045-1279
Range on HMM: 57-291/308.0
KDHITESYAYLPEDKHRYPTVPCKPSTAVEVivDGKRAPIHANWVPTP--GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYL
   .. ..     ||.||. ...  .. | .  |..   |.|..|...  ..|..|||||.| . |.|||| |.....|..|||. . ||. ..    | 
lleysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYw

PMWPR-NDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS--EKPIVVHCSNGIGRSMAFIG
|. .  . |..|.| .......   ......| ... .. ..   ||.||..|  | . ||| |  .  ...|.|.||  ..|||||||.|.||...|| 
plelgggsleygkftvtllseev..lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfia

TEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
 ..| .|.|.. .. . ||.|.| |.|.. ||| .|....
ldllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0047943 (Phosphotyrosine protein) phosphatases II 1055-1279 8.4e-54 178.2 In-house 37-264 (273) alignment 
Range on Protein: 1055-1279
Range on HMM: 37-264/273.0
LPEDKHRYPTVPCKPSTAVEViVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRN-DLQVG
   ||.||. ...  .. | .  ||.   |.|..|... ....||||| | . |.|||| |.... |..|||. . || ... .  | |..  .  |..|
enkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltyg

RFMIKMTNMDFivQKNIMRRSFKVADSTGKFaARTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIGTEYLARQV
.| .......    .... | ... ..  .   || ||..|  | . ||| |  .  |..|.|.|      |..|.|||||.|.||...||  ..| .|.
kftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldql

EADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|.  .. . ||.|.| ..|...||| .|....
ekeggvdvleavkllrsqRpgmvqtpeqyrfl
0039614 (Phosphotyrosine protein) phosphatases II 1041-1279 1.6e-53 177.5 In-house 42-281 (297) alignment 
Range on Protein: 1041-1279
Range on HMM: 42-281/297.0
TTIDKDhITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK----RAPIHANWVPTPGH-PHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWK
  .  | ..... .   ||.||. ... ... | . . ..       |.|..|... . ...||||| | . |.|||| |. .. |..|||. . ||...
lslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr

nIHNDYLPMWPRndlQVGRFMIKMTNMDFivQKNIMRRSFKVADsTGKFaaRTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSN
    .| |       . |.| ..... .    .....| ..| . .|.   ||.||.||  | . ||| |.   .|..|.|..      ...|..||||.
.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsa

GIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|.||. .||.  .. .|.|   .. . ||.|.| |.|...||| ||... 
GvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 1048-1279 1.6e-53 177.3 In-house 20-266 (284) alignment 
Range on Protein: 1048-1279
Range on HMM: 20-266/284.0
ITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK----RAPIHANWVPTP-----GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIH
.. ....   .|.||. ...  .. | . . ..       |.|..|...      ....||||| | . |.|||| |.....|..|||. . ||. .. .
lsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekc

NDYLPMWpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS------EKPIVVHCSNGIG
  | |..  . |. |.|........   ......| ... .   .   ||.||..| .| ..||| |     |....|...      ..|||||||.|.|
aqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvg

RSMAFIGTEYLARQVEADP---TIELTEALKHLHEHRWNGVQTNSQLYWM
|...||  ..| .|.|..    .. . ||.|.| |.|.. ||| .|... 
RtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
0043336 (Phosphotyrosine protein) phosphatases II 1034-1278 7.8e-53 175.1 In-house 23-268 (278) alignment 
Range on Protein: 1034-1278
Range on HMM: 23-268/278.0
TIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGKR---APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRK
  |  .......|... .. .   ||.||. ... ... | . ..|..     |.|..|... .|..||||| | . |.|||| |. .. |..|||. . 
llefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtel

VEYWKNIHNDYLPmwpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAaRTLTHYQYSQWAERGVPKSHVETYELMEMVKK----SEKPIVVH
||....    | |   .. |..|.| .......   ......| ..| .   ..  || |||.|  | . ||| |     .....|..    |..|..||
velgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdges.rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVH

CSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
||.|.||...||. ..| .|.|   .. | ||.|.| |.|.. ||| ||...
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf
0051299 (Phosphotyrosine protein) phosphatases II 1048-1279 1.6e-52 174.1 In-house 41-278 (288) alignment 
Range on Protein: 1048-1279
Range on HMM: 41-278/288.0
ITESYAYLPEDKHRYPTVPCKPSTAVEVIVDGK---RAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPM
.. ..     .|.||. ...  .. | . | ..      |.|...... ....||||| | . |.|||| |.....|..|||. . ||. ..    | |.
lsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl

wpRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADST---GKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAF
  .. |..|..........   ..... | ..| . .   |.   || ||..| .| . ||| |  .  .....|.|.    ..|.|||||.|.||...|
..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtf

IGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|  ..| .|.|.  .... ||.|.| |.|.. ||| .|... 
ialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
Y_phosphatase Protein-tyrosine phosphatase 1058-1279 1.7e-51 170.3 Pfam-A 3-229 (235) alignment 
Range on Protein: 1058-1279
Range on HMM: 3-229/235.0
DKHRYPTVPCKPSTAVEV-IVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
.|.||.....  .| |..   .|.   |.||.| .  ....||||| |.. |.||||.|..|..|. |||. . .|  ..  ..| |   .. |. |.. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT
.....     .|... | ... ..... . |......| .| ..|||.|  .  .|...|.||.    .|.|||||.|.||.. |.  ..| .|.||. .
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

IELTEALKHLHEHRWNGVQTNSQLYWM
... ...|.| ..| . ||. .|....
vdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 1058-1279 1.7e-51 170.3 In-house 3-229 (235) alignment 
Range on Protein: 1058-1279
Range on HMM: 3-229/235.0
DKHRYPTVPCKPSTAVEV-IVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
.|.||.....  .| |..   .|.   |.||.| .  ....||||| |.. |.||||.|..|..|. |||. . .|  ..  ..| |   .. |. |.. 
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdik

IKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT
.....     .|... | ... ..... . |......| .| ..|||.|  .  .|...|.||.    .|.|||||.|.||.. |.  ..| .|.||. .
velkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeee

IELTEALKHLHEHRWNGVQTNSQLYWM
... ...|.| ..| . ||. .|....
vdvlqivkelRkqRpgmvqsleqYifl
0040439 (Phosphotyrosine protein) phosphatases II 1049-1278 2.7e-51 170.0 In-house 4-237 (249) alignment 
Range on Protein: 1049-1278
Range on HMM: 4-237/249.0
TESYAYLPEDKHRYPTVPCKPSTAVEVIVDGKRAP---IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMw
.... .   ||.||| ... ... | . . ... .   |.|...... ...|||||| | . |.|||| |. .. ...|||. . ||....    | |. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

pRNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADStGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK------SEKPIVVHCSNGIGRSMAFIG
 .. |..|.|........    .....| ... .. ..   || .|.||  | . |||.|  .. ...|.|.|      ...|..||||.|.||. .||.
.ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

TEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
  .. .|.|   .. | ||.|.| ..|...||. .|...
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
DSPc_SM00195 1045-1279 9.1e-51 168.1 In-house 16-254 (263) alignment 
Range on Protein: 1045-1279
Range on HMM: 16-254/263.0
KdHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDY
| ..||.     ..|.||  ...  .| |..  .    .   |.||.. .. .....|||| | . |.|||| |... .|. |||. . .|  |.  ..|
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

LPMWPRNDLQVGRFMIKMTNMDFIVqKNIMRRSFKVADSTGkFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEK----PIVVHCSNGIGRSMAF
 |    .  ..|.. .|... .    ..| .| ...   .    .|..|.||| .| ..|||.|. .. ||...||||..    |||||||.|.||. .|
wpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
. .... ...|.. .... | .|.| ..| . |||  |. ..
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 1045-1279 9.1e-51 168.1 In-house 16-254 (263) alignment 
Range on Protein: 1045-1279
Range on HMM: 16-254/263.0
KdHITESYAYLPEDKHRYPTVPCKPSTAVEVIVDG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDY
| ..||.     ..|.||  ...  .| |..  .    .   |.||.. .. .....|||| | . |.|||| |... .|. |||. . .|  |.  ..|
k.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdry

LPMWPRNDLQVGRFMIKMTNMDFIVqKNIMRRSFKVADSTGkFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEK----PIVVHCSNGIGRSMAF
 |    .  ..|.. .|... .    ..| .| ...   .    .|..|.||| .| ..|||.|. .. ||...||||..    |||||||.|.||. .|
wpeesggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVhCsaGvgRtgtf

IGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
. .... ...|.. .... | .|.| ..| . |||  |. ..
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
0042113 (Phosphotyrosine protein) phosphatases II 1056-1279 9.5e-50 164.6 In-house 9-235 (245) alignment 
Range on Protein: 1056-1279
Range on HMM: 9-235/245.0
PEDKHRYPTVPCKPSTAVEVIVDGKRA---PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwpRNDLQV
  ||.||. ... ..| | . .|| .    .|.|..|... ....||||| | . |.|||| |. .. ...|||. . .|....    | |.  .. |..
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl..geslty

GRFMIKMTNMDFivQKNIMRRSFKVADsTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK-----SEKPIVVHCSNGIGRSMAFIGTEYLARQV
|.|........    .....| ..| . .|..  |. .||.|  | . ||| ..    ...|.|.|     |..|..|||| |.||...||.  ....|.
gdftvtllseeh..lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

EADPTIELTEALKHLHEHRWNGVQTNSQLYWM
|.  .. | ||.|.| ..|.. ||| ||....
ekelgvsleeavkelrsqRpgavqtpsqyrfl
0045098 (Phosphotyrosine protein) phosphatases II 1046-1279 5.8e-48 159.0 In-house 23-264 (278) alignment 
Range on Protein: 1046-1279
Range on HMM: 23-264/278.0
DHITESYAYLPEDKHRYPTVPCKPSTAVEvivdgkrAPIHANWVPTPghPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPmw
. ||..    . ||.||. ... ... |          |.|......  |..||||| | . |..||| |. .. ...|||. . ||. ..    | |  
seitpalylgnldknRykdilpydhsrVk.......dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp..

PRNDLQVGRFMIKMTNMDFIvqKNIMRRSFKVADS---TGKFAARTLTHYQYSQWAERGVPKSH--VETYELMEMVKK-----------------SEKPI
... |. |.| ....... .  ...  | ..| .       .  |..||..|  | . ||| ..      ||.|....                 |..|.
eggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpv

VVHCSNGIGRSMAFIGTEYLARQVeaDPTIELTEALKHLHEHRWN-GVQTNSQLYWM
.|||| |.||. ....  .. ...  .... | ||.|.| ..|..  ||. .|....
lVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl
0037934 (Phosphotyrosine protein) phosphatases II 1054-1278 1.1e-42 141.7 In-house 8-233 (243) alignment 
Range on Protein: 1054-1278
Range on HMM: 8-233/243.0
YLPEDKHRYPTVPCKPSTAVEVivDGkRAPIHANWVPTPGhphRFIATQSPINATCED----FWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPmwprND
.   .|.||..... . . | .  .|    |.||... ..   |.|||| | . |.||    || |. .. ...|||. . ||....    | |    ..
penlsknrysdilpydhsrvkl..eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp....ge

LQVGRFMIKMTNMDFivQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVK------------KSEKPIVVHCSNGIGRSMAF
 . |.|.......     .... | ...     .   |. .||.|  | . ||| |.   ......|.            .|..|..|||| |.||. ..
vtygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtl

IGTEYLARQVeadpTIELTEALKHLHEHRWN-GVQTNSQLYW
|   .. ...    .. | ||.|.| |.|.. .||| ||...
iaaylmllll....gvdleeavkllreqRpgkavqtpsqyrf
subfamily_PTPRD_pd Subfamily PTPRD 1084-1291 4.2e-39 129.6 In-house 79-280 (564) alignment 
Range on Protein: 1084-1291
Range on HMM: 79-280/564.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWpRnDLQVGRFMIKMTNMDfiVQKNIMRRSFKVaDSTGK
| |... .  ... .|||| |.. |.|||| |....... |||. . .|  |.  ..| |   .   ..|........      .... |.||.   . .
INAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeee..eladyeirtfkl.kkkks

FAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQlYWM
  .|. ..... .| ..|||.|  .  .|.. |...    ..|||||||.|.||. .||  ... ...... |... . .|.| ..|   |||..| |  
sesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQ.YiF

tlgtMYRLIKEY
    ... | |.
....iheailea
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1058-1280 7.2e-39 128.3 In-house 50-280 (305) alignment 
Range on Protein: 1058-1280
Range on HMM: 50-280/305.0
DKHRYPTVPCKPSTAVEVIVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVG----
.| ||  | |     | .        ||||.| ||  |.||| ||.|.. || ||| ||.|  || | |.   .|   .   .|..   .. |.      
gknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgq

RFMIKMT---NMDFIVQKN-IMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEA
. ..|.    ...|  . .  ....  | . .|.  ||  ||| . .| .|||| . .   ||.|  . |  ||||||| ||||. . .  ||.  |. |
kisvkfessvtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildqlla

DPTIELTEA-LKHLHEHRWNGVQTNSQLYWMT
   || |.  |... | | | .||. |  .. 
gqiiedtdkilqkireqrnnsiqtdaqylfvh
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1053-1279 5.6e-36 119.1 In-house 38-268 (281) alignment 
Range on Protein: 1053-1279
Range on HMM: 38-268/281.0
AYLPEDKHRYPTVPCKPSTAVEVIVDG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPmWPRND
|     |.||  .     | |.|  .    .   | ||.||.   ....||||.|. |....|| | ....|. |||| |..|  |     | |  ....
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWP.ddnse

LQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKfaARTLTHYQYSQWAERGVPKSHVETYELMEMV-----KKSEKPIVVHCSNGIGRSMAFIGTEYLA
|..| ...|.|.     ... ..| ||.  ..|.  .|.... .| .| . |||..  |  |  . |     ||.. |.|.||| |.||. ..|. . |.
lkygdvtvkstaee..ekatyierkfkleresge..treveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlv

RQVEAD-PTIELTEALKHLHEHRWNGVQTNSQLYWM
..|||. ....... ...| ..|   |||  |  ..
kaveaeleeldvkavvaelrkernlmvqtvvqyefv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1040-1303 7.9e-36 118.7 In-house 32-298 (319) alignment 
Range on Protein: 1040-1303
Range on HMM: 32-298/319.0
VTTIDKDHITESYAYLPEDKHRYP-TVPCKPSTAVEVIVDGKRA--PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKN
. . ..|.....     ..| ||.  ...  .  |   .||.     | |... .  . ..|||||.|.. | |||| |  ..|.  .||. . ||  | 
lkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkv

IHNDYlpmWPRND-LQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-----KPIVVHCSNG
  . |   ||...  . ||..... . .   ..... | .|.   ...  .|...|.|| .|.. .||..     .|.. ..||      .|||||||.|
klkky...wpeenfeeyGrlivtleeee..eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaG

IGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQlYWMTLGTMYRLIKEYGFDMKIYDQQMA
.||  .||  .    .|. . .... .  ..|   |   ||...| | .   ..   .. .  .... | .. 
vGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq.Ykfiyealleaveagdteievqdlrdr
subfamily_PTPRB_pd Subfamily PTPRB 1043-1279 9.8e-36 118.3 In-house 37-277 (293) alignment 
Range on Protein: 1043-1279
Range on HMM: 37-277/293.0
IDKD-HITESYAYLPEDKHRYPTVPCKPSTAVEV-IVDG--KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIH
..||  .. . .   ..| ||  .     . |..  ...  .   | ||..|    |. ||||| |.  | .||| |... ... |||. . ||  |   
vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

NDYlpmWPRN--DLQVGRFMIKMTNMDfiVQKNIMRRSFKVADstgKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS------EKPIVVHCSNG
..|   ||..  . . |   ..... .  .... . |..|.     . . |....|..  |.. |||..     .....|...      ..||||||| |
eeY...WPadeepvlyGdikvtlvaee..eledwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaG

IGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
.||. .||  . | ...| . .....  . .| |.| . |||..|  ..
vGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1056-1279 1.6e-35 117.6 In-house 41-269 (307) alignment 
Range on Protein: 1056-1279
Range on HMM: 41-269/307.0
PEDKHRYPTVPCKPSTAVEVIVDGKRA-PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGR
  || ||  |.|.  . . | .||  .  ||||.. .  .|..||..| | ..|  .||||..| .|| ..|. . .|  |   ..| |.   . |  | 
ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfge

FMIKMTNMDFIVQKNIM-RRSFKVADSTGKF--AARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLAR-QVEAD
    ..  .. ..|        .|..   ..   .||..|.|...| .||||.  . . .|.| |.  . |.||||| |.||| . ..  ..    ..  
apntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGi

PTIELTEALKHLHEHRWNGVQTNSQLYWM
   .. . .. | ..|   .||. |  ..
nckdmkklveelrsqrhyaiqteaqylyl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1058-1279 1.7e-35 117.4 In-house 49-271 (288) alignment 
Range on Protein: 1058-1279
Range on HMM: 49-271/288.0
DKHRYPTVPCKPSTAVEVIV---DGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDL--QV
.| ||. .     ..|..       .   | |...   .. ...||||.|. .| .||| .  ..... |||.   ||  |.  ..|   || .|   . 
kknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeY...WPdadkpkny

GRFMIKMTNMDfiVQKNIMRRSFKVAdstGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS---E-KPIVVHCSNGIGRSMAFIGTEYLARQVE
| . .....     ..... |.. .     |   ...|.|||  |.. |||.|. .  ||...|| .   . .||.||||.|.||.  ||  . |  .||
Gsvtvtlvesk..eledfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidave

ADPTIELTEALKHLHEHRWNGVQTNSQLYWM
.. .|........| ..| . ||| .|  ..
eedyiDvagtvaklRkqRallvqtlkqYefi
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1055-1280 1.1e-34 114.5 In-house 54-282 (305) alignment 
Range on Protein: 1055-1280
Range on HMM: 54-282/305.0
LPEDKHRYPTVPCKPSTAVEVIVDGKRAPIHANWVPTPGHPH-RFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDL--Q
. . | ||  |||.  .|| .        ||||.|  |  |. |||..| |.. | ..|| | .|  ||.|||. . ||  |    .| |.   . |  .
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

VGRFMIKMTNMDFIV-QKNIMRRSFKVADSTGKfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLA-RQVEA
 |  . ...    .  . .|    .... | ..    .. | |...| .||||  .. . ||.  .. |. ||||||| ||||. . .  ||.  .  | 
sgivvenvsgskpmerdaeiqitllnltysgdq..kmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilekiaen

DPTIELTEALKHLHEHRWNGVQTNSQLYWMT
 |   . | .| | ..|   .|.. |  .. 
kpcppmpelvkalrdqrafsiqndvqylfih
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1083-1280 2.3e-34 113.9 In-house 76-272 (318) alignment 
Range on Protein: 1083-1280
Range on HMM: 76-272/318.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWP-RNDLQVGRFMIKMTNmDFIVQKNIMrRSFKVADsT
 | ||...   . . .||.|.|.  |.|||| |  . .   |||. ...|  |.  . |   || ..  . |. ...... .. ... .. |.|||   |
yinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhry...WPskgsrsygklvvelke.evelsdyvl.refkvtr.t

GKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQl
.. . |.   |.| .|...|||.| ..  .|.  |.| .     .||||||| |.||   ||  . | ....|. .... .  |.| |.|   |||..| 
eeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedq.

YWMT
| . 
yefi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1080-1276 3.1e-33 110.2 In-house 73-272 (305) alignment 
Range on Protein: 1080-1276
Range on HMM: 73-272/305.0
KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVAD
..  | |..| .  . ...|..|.|.. | .||| . ... |..|||. . ||  |.  . | |   ... . |.|......      .. . | .|.. 
dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksek..tasdyieRklkisi

STGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK----S-EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNS
  ..   ||...||  .| . |||..     .|.. |.|    . ..|..||||.|.||. .||  .    ..... .... | ||.| ..| . |||  
ededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtld

QL
| 
qY
subfamily_PTPN3_pd Subfamily PTPN3 1058-1278 4.1e-33 109.5 In-house 43-266 (280) alignment 
Range on Protein: 1058-1278
Range on HMM: 43-266/280.0
DKHRYPTVPCKPSTAVEViVDGKRAPIHANWV----PTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwPRNDLQVG
.| ||  .    .| |.. ....   | ||.|    |. |   |.|||| |.. |..||| |  . ... |||.   ||  .     | |  . . |. |
sknryrdilpydatrvkl.kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPe.tedeleyg

RFMIKMTNMDfiVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEA
.|..|... |   .|... | . . |.. |   |.... || .|.. |||... .  |..| |.|     |.|.||||| ||||.  .|  |     .||
efsvkceked..etksyvlrelvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalaliea

DPTIELTEALKHLHEHRWNGVQTNSQLYW
   .   . .... . | . |||.||  .
aepvypldivrtmrdqramlvqtasqykf
0051429 (Phosphotyrosine protein) phosphatases II 1084-1288 5.2e-33 110.2 In-house 7-226 (272) alignment 
Range on Protein: 1084-1288
Range on HMM: 7-226/272.0
IHANWVPTPGH---PHRFIATQSPINATCEDFWAMcMQYEVEHIVMVGRK--------VEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMR
|.|..|...|.   |.|..... | ..|..|||..  .. . .||.. .           || .|.  .||.... . ..  ... .|.. .... ... 
iNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyil

RSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHveTYELMEMVKKsEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIE--------LTEALKHLHE
| . .    .  .||...|..| .|  .|||..     ||.|.. . ..|..|||| |..|.  ..   .|...|...  ..        | ||...| .
rellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelra

HRWNGVQTNSQLYWMTLGTMYRLI
.| . |||  |...     .  | 
qrpgavqteeqylflyeallellr
0041856 (Phosphotyrosine protein) phosphatases II 1058-1281 7.4e-33 109.0 In-house 3-165 (182) alignment 
Range on Protein: 1058-1281
Range on HMM: 3-165/182.0
DKHRYPTVPCKPSTAvevivdgKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrKVEYWKnihndylpmwprndlqvgrfmi
||.||. ... . .            |.||..  . .. |||||| | . |..||. |  .. . .||..   . ||                       
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywp......................

kmtnmdfivqknimrrsfkvadstgKFAARTLTHYQYSQWAERGVPKsHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQveadpTIELTE
                         ..  |. ..|.| .|   |||    |.....|.|.....|..|||| |.||. ....  .. ..      . |.|
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....gvslee

ALKHLHEHRWNGVQTNSQLYWMTL
|.|.. ..|...|.| .|...  |
avklvrsrRpgmvitpnqyfflql
subfamily_PTPN12_pd Subfamily PTPN12 1083-1277 1.3e-32 107.9 In-house 70-267 (290) alignment 
Range on Protein: 1083-1277
Range on HMM: 70-267/290.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIvQKNIMRRSFKVADStg
 | ||..  .  ....||.|.|. .| .||| | ....|| .||. |.||  |.  . | |    ..|..| | ..... . . ..... |..||  .  
YinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav.dddflirtLkveaq..

kFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEAD---PTIELTEALKHLHEHRWNGVQTNSQ
  . |... ..| .| ..|||.|. .  ||.|.|..    ...|.||||| |.||  . |  .|  ....|.   ..... . . .| ..|   |||. |
.kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeq

LY
  
ye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1059-1291 2.9e-32 106.9 In-house 46-276 (288) alignment 
Range on Protein: 1059-1291
Range on HMM: 46-276/288.0
KHRYPTVPCKPSTAVEVIvDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIK
. ||  .|.   | | .  |     |.|| |..  ...|.| .|.|.|.| | .| | .. .||.|||. . .|  |.  ..|.|.   .  ..||.   
rdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigrlctv

MTNMDFIVQKNIMRRSFKVADSTGKFAarTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEA
. .    ..| .    ...   . .     . .  . .| . |||....    |.|..|. .||||||.|.|.||....| .   ....  |  . . . 
vkkkradidklvkvsllriskegeekv..ivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlililialeslrlddflgirsl

LKHLHEHRWNGVQTNSQ-LYWMTLGTMYRLIKEY
|..| |.| . .||. | ||   .   . |.| |
laklreerfkaiqtemqylyvhrcvleelllkky
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1082-1278 7.6e-32 105.7 In-house 85-281 (298) alignment 
Range on Protein: 1082-1278
Range on HMM: 85-281/298.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPR-NDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADS
  | | .. .  . . ||||| |...| |||| | ...... |||.   .|  |   . |   ||  .  . |.. ... . .  .. ... | .||...
dYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhky...wPdegketygeitvsllske..efadlivrklkvskk

TGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS-----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQ
. .   |.. . ....|...|||. .    .|.. |..|     .||..|.||.|.||| .||  . .  .|... .... ...| | ..| . |||..|
kee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeq

LYW
  .
Yvf
subfamily_PTPN13_pd Subfamily PTPN13 1041-1277 3.6e-31 103.4 In-house 24-259 (273) alignment 
Range on Protein: 1041-1277
Range on HMM: 24-259/273.0
TTIDKDHITESYAylPEDKHRYPTVpcKPSTAVEVIVDGKRAPIHANWVPTP--GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIH
 ..|. ..... .   .|| ||  |   |  .  |..... . | |...  |   . ...||.| |.  |..||| |  . ..| |.||  ..|  |   
kpldtcevgkkke..nkdknryrnv..lPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkc

NDYLPMWPRNDLQVGR-FMIKmtNMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELME---MVKKSEKPIVVHCSNGIGRS
. | |   .. |.|   . ..  ...   ...   |...| ||  . ..| ..| .. .| . |||.| .|  ...     ..... ||||||| |||||
hrywPesknkklkvsnrleve..llkvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrs

MAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
 ..|  . .   .| |  ....| ...| | |   |||. |  
Gtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyi
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1058-1296 3.9e-31 102.8 In-house 58-287 (290) alignment 
Range on Protein: 1058-1296
Range on HMM: 58-287/290.0
DKHRYPTVPCKPSTAVeVIVDGK-RAPIHANWVPtpGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
 | ||  |.|   | | .. ||     .|||.|   |    || || ....|  |.| | .| .|  |||.   .|  |   ..| |    . |  | . 
kknrykdvvcndktrv.ilkdGydGdyvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeit

IKMTNMDfIVQKNIMRRSFKVADST-GKfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIEL
.  .. |   ..||... . | |   ||     | |..   | .. |..| .    .. ...|   |.||||| ||||. .|.  |  .. .     ..|
vlcseed.dkdaniikktlsvrdkdsGk..ehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilldGkeldl

TEALKHLHEHRWNGVQTNSQlYWMTLgtmyRLIKEYGFDMK
 .  . | . | | || . | | . .    ... ..| |.|
ldlvralrnsrlnsvqvdiq.ylalv....eilldlGkdfk
subfamily_Ptp69D_pd Subfamily Ptp69D 1082-1310 6.7e-31 102.5 In-house 77-303 (307) alignment 
Range on Protein: 1082-1310
Range on HMM: 77-303/307.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWP-RNDLQVGRFMIKMTNMDFivQKNIMRRSFKVADS
  | |... .  . ..||| | |..|| .||| | .. ||. |||.    |. ..  . |   ||  .  | |  ..|. . ..  ... ..|...|.  
dYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakY...Wpiedevqygdilvklvseek..hsdyiiReldvskk

TGK----FAARTLTHYQYSQWAERGVPKSHVETYELMEMV----KKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQT
  .     . | .. |.| .| .  ||..     .|.|.|    |... |||||||.| |||  |.  . |  |..|. .... |  |.|...|   || 
keesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqs

NSQLYWmtlgtMYRLIKEYGFDmKIYDQQMAMFNDVVK
  |  .     .|| . .|       |...  ..| ..
leqYvf.....lyralldyssy.gdtdedvddledaie
subfamily_PTPRK_pd Subfamily PTPRK 1077-1277 7.9e-31 102.0 In-house 65-267 (314) alignment 
Range on Protein: 1077-1277
Range on HMM: 65-267/314.0
VDGK--RAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIKMTNMDfiVQKNIMRRS
.||      | |... .  .|. ||.|| |.. | .||| .  ...   |||.   ||  .     |   || .  . | . ... ...  ...... | 
idgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky...WPedtevygdikvelvete..llaelvvri

FKVAD-STGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNG
|.|   . |. . |.. ..|. .|.. .||.|     .|.  ||||.     .||||||.| ||. .||  . .   .| . .... .| | | ... | 
frveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnm

VQTNSQLY
|.|. |  
veteeqyk
0043147 (Phosphotyrosine protein) phosphatases II 1082-1279 1.1e-30 102.0 In-house 6-153 (172) alignment 
Range on Protein: 1082-1279
Range on HMM: 6-153/172.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKveywknihndylpmwprndlqvgrfmikmtnmdfivqknimrrsfkvaDST
  |.|...... .|.|||||| | . |..|||.|. .. . |||.. .                                                   .
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................lyd

GKFAARTLTHYQYSQWAERGVPkSHVETYELMEMVKK-----SEKPIVVHCSNGIGRSMAFIGTEYLArqveadPTIELTEALKHLHEHRWNGVQTNSQL
...  |.  .|.|  |   ||| .    .|..| ...     ...|..|||| |.||. ...   ..         . | ||.... |.|...||. ||.
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsqy

YWM
.. 
rfl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1084-1293 1.7e-30 101.1 In-house 49-265 (290) alignment 
Range on Protein: 1084-1293
Range on HMM: 49-265/290.0
IHANWVPTPgHPHRFIATQSPI-------NATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHN----DYLPMWPRNDLQVGRFMIKMTNMdfIVQKNIMR
|||| |  | .  |.|.||||        |.| |.|| | .| .|...||..   |  .| ..     | |.   ..|... . .| ...  . .... .
iHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCksk..ekeddvet

RSFKVAdsTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEyLARQVE--ADPTIELTEALKHLHEHRWNGV
|   |    ..    |.||.....| .. |....    .|...||.|. |..||| .|| || |.   . |. |        ..|...|| | ..| . .
Relvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaii.lgyQkiaetsgsvkledvlkalrkqralai

QTNSQLYWMTLGTMYRLIKEYGF
... .| ..  | . ..|...  
tsalelafvdagivllaievldq
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1061-1279 2.4e-30 100.4 In-house 25-256 (270) alignment 
Range on Protein: 1061-1279
Range on HMM: 25-256/270.0
RYPTVPCKPSTAVEV---IVDGKRAPIHANWVP-TPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFM
||  .  .| | | .     | . | | ||.|.   |.....||...| ..| ..|| | .. .|. |||.   .|  ..  . | |  | . ...   .
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkledgk

IKMTNMDFIVQKNIMRRSFKVAdSTGKfaARTLTHYQYSQWAERGVPKSHV---ETYELMEMVKKS-------E--KPIVVHCSNGIGRSMAFIGTEYLA
||....    ..  ...  ..  ..|.   | |.|..| .| ..|||...    .| .|..|...        .  .|..||||.|.||.  .| ...  
ikvlalseekeegyiltrlrle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtlialDiav

RQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWM
| .| .  ..... ...| ..| . ||.  |  ..
rlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_PTPN9_pd Subfamily PTPN9 1057-1278 3.4e-30 100.1 In-house 43-281 (297) alignment 
Range on Protein: 1057-1278
Range on HMM: 43-281/297.0
EDKHRYPTVPCKPSTAVEVI-VDGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVG
  | ||  | |  .| | .  ||..     |.||.|    ... ||||| |.. |..||| |  . ||  |||. | ||  .   . |   || .. .. 
leknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqy...Wpleeessa

RF-MIKMTNMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK-----------------SEKPIVVHCSNGIGRSM
.|  ....|..  .... . |.... ... .   |..||.|.  | . |||.|  .  ...|.|..                 |. ||||||| ||||. 
efgdlsvsnveveeeedykvrvleiknvkte.esrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtG

AFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
.||  ..   ..|   |....|..|.| . |   .||. | ..
tfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1025-1277 5.1e-30 99.4 In-house 16-268 (287) alignment 
Range on Protein: 1025-1277
Range on HMM: 16-268/287.0
HKPAKFYNTTIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPSTAVeVIVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHI
.|  . ...    ..  | ..|..| . |   .|| |.  .  .    | .. . .   | | .. .  . ..||...||.  |  .|| .  . .|. |
akgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrv.llkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMVGRKVEYWKNIHNDYlpmWPRND-LQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERG-VPKSHVETYELMEMVKKS---
||. .. |  ...  .|   || .. . .| . |...| .  |... . | ..|  .. . . .... ||. .| ..| |..       . ||.|.    
vmlcqekendeevcyqy...WpeeksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

-EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
 . .||||||...|||  |.  .   .... . .|.. . ||.    . . ||| .|  
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqyk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1088-1278 6.8e-30 99.1 In-house 44-233 (250) alignment 
Range on Protein: 1088-1278
Range on HMM: 44-233/250.0
WVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNiHNDYLPMwpRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTgKFAAR
.. .    . |||||.|..|| |||| | ...... |||.   .|  |.  ..|.|.   .  . |  .... . .  .  ... | .|..  . |   |
flhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv..ekaekyGdvtvsllske..efadytkrklklskak.kader

TLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
.. .... .| ..|||.      ||.. |..|.     .|..|.||.|.||| |||  . .  ... . .... . .| | ..| . |....|  .
ivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvf
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1083-1277 2.9e-29 96.9 In-house 78-273 (290) alignment 
Range on Protein: 1083-1277
Range on HMM: 78-273/290.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDlqVGRFMIKMTNMDfIVQkNIMRRSFKVADSTG
 |.| ..    . ...||||.|.. |  ||| . .| .|  |||.   .|  |.  . | |  . ..  .| | ||..|   ... ....| ..| ... 
yinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtka..ygefsikllnee.tln.eyierklevknkns

KFAARTLTHYQYSQWAERG-VPKSHVETYELMEMVK----KSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
. |....|.|| . | . | |.. .  .  . ||.|    . ...||||||...|||  |. ..    ... .  |.. . ||..   . . |||. |. 
agakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1057-1277 1e-27 92.0 In-house 29-258 (274) alignment 
Range on Protein: 1057-1277
Range on HMM: 29-258/274.0
EDKHRYPTVPCKPSTAVEVIVDGKRAP----IHANWVPTPGH-PHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQ
. | || |.   . . | .  .  ...    | ||..  ...  . ..||| |.  | .||| |  | ||. |||. .  |  ..  . | |     ...
qtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyeis

VGRFMIKMTNMDFIVQKNIMRRSFKVADSTGkfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE-------KPIVVHCSNGIGRSMAFIGTEYLA
     ..... . . ...   |.. .  ..     |...|| |..| .. .|..  .  .|.. |..|.        |.||||| ||||  .||...   
erygdveikvekiverndysvrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

RQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
||.... .... .   .|  .|   |||..|  
rqlreeivvdvlkivcnlrldrGGmvqtseqye
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1078-1276 1.1e-27 91.8 In-house 74-268 (315) alignment 
Range on Protein: 1078-1276
Range on HMM: 74-268/315.0
DGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIkmTNMDFIVQKNIMRRSFkv
| .   . ||...   ...|.||.|.|  |. .||| . ..... .|||.   ||  |.  . |   || ...  |.. .  | ..  |....  |..  
dphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaeky...wpdkkviyGkitv..trkseevnteytvrtl..

aDSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKK----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTN
   . .   |..  ..|. | . ||||. .   .|.  ||.    |  .||||||.|.||. .||  . .  |.||.  |.. .... . . | . ||. 
.svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqva

SQL
 | 
eqy
subfamily_PTPRG_pd Subfamily PTPRG 1078-1279 4.5e-27 89.5 In-house 70-279 (563) alignment 
Range on Protein: 1078-1279
Range on HMM: 70-279/563.0
DG---KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwpRNDLQVGRFMIKMTNMDFIVQK---NIM
 |   |   | ||..    . . ||||| |.. |..||| |  . .|. |||.   ||  ..  . | |    . ...| . ..... . ..     ...
pgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlv

RRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVetYELMEMVKKSE------KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEH
 . .|. .   .   .. ..|.|..| . |||.. .  ..|. ..|.|        |||||||.|.||.  .|  . | .|.... .... . |||.. .
iknlklkkkkqcdteklvrqyhytkWPdhgvPehsl..pvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraq

RWNGVQTNSQLYWM
| . |||. | ...
RnflvqteEqYifl
0049260 (Phosphotyrosine protein) phosphatases II 1091-1279 7e-27 89.4 In-house 4-142 (152) alignment 
Range on Protein: 1091-1279
Range on HMM: 4-142/152.0
TPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLpmwprndlqvgrfmikmtnmdfivqknimrrsfkvadstgkfaartlt
  ..|..||||| | . |..||| |  .. . .|||. . .| .|  .. |                                                 
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi................................................

HYQYSQWAERGVPKSHVETYELMEMV----KKSEKPIVVHCSNGIGRSMAFIGTEYLArqveadPTIELTEALKHLHEHRWNGVQTNSQLYWM
.|.. .|   |||...   ..|....    .....|..|||| |.||. ...   ..         ..| ||.... |.|...|.. .||.. 
qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1083-1276 7.8e-27 88.5 In-house 73-265 (515) alignment 
Range on Protein: 1083-1276
Range on HMM: 73-265/515.0
PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTG
 . |  .|.    . .||.| | .|. .||| . .|..|  |.|| .. |  |     | |  | . .. | . ...  ..     . ..| ..|  .  
yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsle..actggikrkltvlkgdd

kfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
   .||.| ... .| ..||||       |.  || .    . |...||| |.||   .|  .    ...   .... . .. . ..|   |||. | 
...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqy
WSN Domain of unknown function 27-93 9.4e-27 82.7 Pfam-A 2-68 (69) alignment 
Range on Protein: 27-93
Range on HMM: 2-68/69.0
KPTDYLDHITIIAHIANGITLQAGLMNGTIQIDEVVGEMLNLGSANVSDLINYKPDKILELIKKLKE
.....|....|||...|||.|||||.||.| ||.|. |.||.||...|.|.....||. | ..||.|
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_PTPN23_pd Subfamily PTPN23 1091-1277 1.4e-26 87.9 In-house 79-270 (288) alignment 
Range on Protein: 1091-1277
Range on HMM: 79-270/288.0
TPGHPhRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRfmIKMTNMDFIVQKNIMRRSFKVADsTGKFAARTLT
.|| |  |||||.|.. |  ||| | ..  .. |||.  | |  |.  . | |    .  . |   ...|  .    .. ..| .|.    .. | ....
spgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd..lsvtlksvretethvervlklet.ldadavksvs

HYQYSQWAERGVPKSHVETYELMEMVKK--------SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTI-ELTEALKHLHEHRWNGVQTNSQLY
| |. .|.| |||.|  .  .... |..        |..|.||||| |.||. .|      .|..|... . .. . ...| | | . ||...|| 
hlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlk
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1057-1290 7.3e-26 85.8 In-house 36-273 (285) alignment 
Range on Protein: 1057-1290
Range on HMM: 36-273/285.0
EDKHRYPTVPCKPSTAVeVIVDGKRAPIHANWVPTPGHPH-RFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRF
 |  ||  | |   | | |. .  |  |||.|.  ||. .  .|.|| |.  |  ||| |  | .. ...|.   .|   .    | |    . ...|..
pdlnryadvrcieetrv.vlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

MIKMTNMDFIVQKNIMRRSFKVADSTGK-FAARTLTHYQYSQWAERGVPKSH---VETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
 | .|.         .  .. | ..         . | |   | ..  |.     .| |. .. |.  ||||.|||| |.||. .|.| .| . ..  .|
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirimenp

TIELTEALKHLHEHRWNGVQTNSQLYWMTLGTMYRLIKE
 ||. . .. ..  |.. ||.  |. .. .  |  .| |
niemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1080-1277 8e-26 85.6 In-house 71-267 (315) alignment 
Range on Protein: 1080-1277
Range on HMM: 71-267/315.0
KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRfmIKMTNMDFIVQKNIMRRSFKVAD
..  | |  ...  . . .||.| | .|. .||| | .|..|  ||||  | |  |   . | |    .  . |   ||.. ..   . . . | . . .
dsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGs..ikvellsleadtdgvarklvtrk

STgkfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQ
|    . ||.| .|. .| ..||.|      .|.  || .    | ...|||| |.||.  .|  .    |..   .... . .| | ..|   |||. .
se...esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteee

LY
  
ya
subfamily_PTPN1_pd Subfamily PTPN1 1059-1279 8.7e-26 85.3 In-house 35-263 (290) alignment 
Range on Protein: 1059-1279
Range on HMM: 35-263/290.0
KHRYPTVPCKPSTAVEvIVDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPR-NDLQVGRFMI
. ||  |     . .. . ...   | |. |  .   ...| || |.  |.. || |  . .   .||. . ||  ..   .| |.  . . |..    .
lnryrdvspydhsrik.leradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtkl

KMTNMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS------EKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
|.. .   .... ..| ... . . .  .|...|. | .|.. |||.|     ...  |..|        | |.||| ||||| .|.  . .  ..|.  
kvkliseerksyytvrllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkd

T---IELTEALKHLHEHRWNGVQTNSQLYWM
    ... . | .| ..|   .||  || . 
dlssvdikkvllelrkyrlGliqtadqlrfs
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1084-1281 9.2e-26 86.0 In-house 56-249 (284) alignment 
Range on Protein: 1084-1281
Range on HMM: 56-249/284.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkveywKNIHNDYLPMwpRNDLQVGRFMIKMTNMDFIVQknIMRRSFKVADSTGK
| | ..    .....|||| | . | .||| |  .|..  ||..       |.   .| |   . . . .|| .|.. ..   .   . |...... . .
inasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl..kivikeerfkvkvdsveesee..yvvrdielsedgke

FAARTLTHYQYSQWAERGVPKSHVETYELMEMVK------KSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
   |... . .  | . |||.. ..   |.. |.      . ...|||||| |.||. ..|  . |  ... .  ... . .. | . | . ||   | .
kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqyk

WMTL
..  
fiys
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1041-1281 1.2e-25 85.6 In-house 44-285 (319) alignment 
Range on Protein: 1041-1281
Range on HMM: 44-285/319.0
TTIDKDHITESYAYLPE--DKHRYPTVPCKPSTAVEV-IVDGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkveywK
. .  .  . ..| |..  || |.  .     . | .  ..|.     | | .|    .. ..||.| | . | .||| |  .|..  ||..       |
cklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......k

NIHNDYLPMwpRNDLQVGRFMIKMTNMDFIVQknIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVK------KSEKPIVVHCSN
.   .| |   . . . .|| .|.. ..   .   . |...... . .   | .| . .  | . |||.. ..   |.. |.      . ...|||||| 
dkcsqywpl..kivikeerfkvkvdsveetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsa

GIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTL
|.||. ..|  . |  ... .  ... . .. | . | . ||   | ...  
GvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiys
subfamily_PTPN6_pd Subfamily PTPN6 1056-1278 2.1e-25 84.3 In-house 96-288 (306) alignment 
Range on Protein: 1056-1278
Range on HMM: 96-288/306.0
PedkhryptvpckpstavevivdgkrapihanwvptpghPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLqVGRf
                                        ...||||  ...| .||| | .| . . |||. ..||  |.    | |   ...   |. 
s......................................dksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGk.

mIKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS--------EKPIVVHCSNGIGRSMAFIGTEYLARQV
 |..||..   ... . |...|.  . |  .|.. .|.. .| . ||||.     ...| |..         . |||||||.||||  .|| .. | ...
.isvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkli

E---ADPTIELTEALKHLHEHRWNGVQTNSQLYW
|    |  |.. .. | ..|.|   |||..|  .
ekkgldadidiqklvksvreqrsglvqteqqykf
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1084-1278 2.8e-25 84.1 In-house 82-275 (297) alignment 
Range on Protein: 1084-1278
Range on HMM: 82-275/297.0
IHANWVPtpGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIhNDYlpmWPRNDLQ-VGRFMIKMtnMDFIVQKNIMRRSFKVADSTG
. | .|.  |  ||.|.|| | .|| .||||| ....|  |||.  . |  |.    |   |. .  .  |   ...  .    ..  ..|...|. .  
vnasfvk..gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdkkc.ary...WsdkgvttfGdvsvvl..lsvsereGfikrelevtkgka

KfAARTLTHYQYSQWAERGVPK--SHVETYELMEMVKK-----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQ
| | | .  ||. .| .. |..  |     .|.. |.|     .| |..|||..|.||   ..  .    ... . .... . .|.| ..| . |||. |
k.arrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeq

LYW
  .
ykf
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1085-1276 3e-25 83.7 In-house 61-255 (283) alignment 
Range on Protein: 1085-1276
Range on HMM: 61-255/283.0
HANWVP---TPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwpRNDLQVGRFMIKMTNMdfIVQKNIMRRSFKVADST
 | ..|      . ...|..|||.. |  ||| |  . ..  |||. .  |  .     | |   |   . | | . . .     ..  ... . .  ..
navfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPk..rGsedyGeftvtlrke..ttsnsfiikelllrvns

GKFAARTLTHYQYSQWAERGvPKSHVETY---ELM-EMV-KKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
   ..  |.|||. .| | | ... ...    ...     .. . |||||||.||||. .||.      .. ..  ... . .| . |.|   |||  | 
sakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqy
subfamily_PTPRA_pd Subfamily PTPRA 1087-1291 4.2e-25 83.3 In-house 92-294 (330) alignment 
Range on Protein: 1087-1291
Range on HMM: 92-294/330.0
NWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRND-LQVGRFMIKMTNMDFIVQKNImrRSFKV---ADSTG
 ..    . ..|||.| | . | |||| |  ...   |||.    |  ..  . |   || .  .  |   ... ..  .|.  .  | | |   .|.| 
sfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqy...wPdeGlvtyGnirvevedetvlvdytv..rkflvqqlpdatr

KFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
. ..| .. . .  | . |||   .   .|.. ||| .     ||||||| |.||. .||  . .  .|.|.  ... |..|.|   | . |||. |  .
ekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyef

mtlgtMYRLIKEY
     .|. ..||
.....iykvlley
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1052-1314 4.3e-25 83.1 In-house 38-301 (312) alignment 
Range on Protein: 1052-1314
Range on HMM: 38-301/312.0
YAYLP-EDKHRYPTVPCKPSTAVEVIVDgKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLP-MWPRND
 |.|   |  ||| . |       .  | .   ||||.|    .| ||..||.|.. ||  || ...      |...   ||   .    |.  .    |
taflkfkdlnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

LQVGRFMIK---MTNMDFIVQKNIMRRSFKVA-DSTGKfaARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLAR
|.  |   .     ..    . .|  | .||   .||.     | |||.. | . |.| |   .. |.  |||  ||.. ||| |.||. ...  | .  
ledhrvyteycteieiggkskdkithrvlkvvvkatgq..esklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmia

QVEADPTIELTEALKHLHEHRWNGVQTNSQlYWMTLGTMYRLIKEYGFdMKIYDQQMAMFNDVVKRLEA
 .      .. ...  |   |   |..  | | ..| ..  ..   |. .|  .|... |...  ...|
alrhprkqnvkdsfvllrkdrarsvrvfpq.yvyalrcvleflyskgl.ykrneqewtkfketyakika
0036282 (Phosphotyrosine protein) phosphatases II 1084-1278 2e-24 81.6 In-house 5-161 (174) alignment 
Range on Protein: 1084-1278
Range on HMM: 5-161/174.0
IHANWVPTPGHPHRFIATQSPINatcedFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMwprndlqvgrfmikmtnmdfivqknimrrsfkvadsTGK
|.|...     . |.||.| | .     ||.|. .. ....||. . .|  .    .| |.                                    . .
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................lre

FAARTLTHYQYSQWAERGVPKSHVeTYELMEMVKKS-----EKPIVVHCSNGIGRSMAFIGTEYLARQVEaDPTIELTEALKHLHEHRWNGVQTNSQLYW
.  |.  .|.|  |  .||| ...  .|... |..      ..|..|||| |.||. ....  .. |. .  ....  . .. |. .| ..||| ||...
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrf
0046846 (Phosphotyrosine protein) phosphatases II 1082-1278 9.5e-24 79.5 In-house 13-164 (176) alignment 
Range on Protein: 1082-1278
Range on HMM: 13-164/176.0
APIHANWVPTPghphRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLqvgrfmikmtnmdfivqknimrrsfkvadst
  |.||.. ..    |.|||| |.. |..||..|  .. ....|..   ||. .    .| | . ....                               
dyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...............................

gkfaartltHYQYSQWAERGVPKShVETYELMEMVKKSE---KPIVVHCSNGIGRSMAFIGTEylarQVEADPTIELTEALKHLHEHRW-NGVQTNSQLY
         .|..  | . ||| .    .||.|....     .|..|||| ||||. ...        .| .  . . |||... |.|. . ||| .|..
.........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQyr

W
.
f
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1057-1278 2.8e-23 77.1 In-house 39-268 (287) alignment 
Range on Protein: 1057-1278
Range on HMM: 39-268/287.0
EDKHRYPTVPCKPSTAVEVIVDGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWpRNDLQVGR
  | ||  |     | | .  .|.   . | ||.|..  . ..|||.|.|| ||  ||| . .. ..  .... |.||  ..    | |   .  ..|| 
vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvGG

FMIKMTNMDFIvQKNIMRRSFKVADSTGKfAARTLTHYQYSQWAERGVPKSHVETY-------ELMEMVKKSE--KPIVVHCSNGIGRSMAFIGTEYLAR
. . . . |   . .   |.....|  ..  || .  ... .| ..... . |          . .|. ....   |.|||.. |||||  .. |  | .
ysvvlldydik.ePeygvralrlidletr.earvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
. |    .. . .. .| |.|   ||.  ||  
rledlGrvdvaavvirlreyraalvqavvqlrl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1046-1277 4e-23 77.1 In-house 36-278 (325) alignment 
Range on Protein: 1046-1277
Range on HMM: 36-278/325.0
DHITESYAYLPE--DKHRYPTV-PCKPSTAVEVI--VDGKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEvEHIVMVGRKVEYWKNIHND
| |.   | .||  .| |.. | . . | .| .    |..   | |... .    . |.|.|.|  || .|.| . ....   .|.|  ...  |.    
dgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvvvlneldlgkdrcav

YLPMWPRNDLQVGRFMIKMTNMDFIvqKNIMRRSFKVADSTGkFAARTLTHYQYSQWAERGVPKSHVETYELMEM-------VK---KSEKPIVVHCSNG
| |    .  . | . .|.  .. |   . . | ..| .  .   .|..  .|.  | . ||.|       ....       |.   |.  ||.||||.|
ywpkemgksktfGglevklrtieei..sdyvhrvldvkqvkk.GetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

IGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
.||. .||    .. .|  .  ... . .|.| ..| . |.|  |  
vGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyi
subfamily_PTPN14_pd Subfamily PTPN14 1093-1276 5.4e-23 76.4 In-house 90-285 (300) alignment 
Range on Protein: 1093-1276
Range on HMM: 90-285/300.0
GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMW--PRNDLQVGRFMIKMTNMDfiVQKNIMRRSFKVADSTGKfAARTLT
|. . .|..|.|.. |..||| |  . .|. |||. .. |  |.    |.|     .. .. |.| .     .    . .. ...|.     |   ||. 
gkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfse..dsdsvittglklkhlpsk.eertvw

HYQYSQWAERGVPKSHVETYELMEMVK-------------KSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
| ||  |...|||.   .  . .|.|.             .|. |..||||.|.||.   | .. |   .| . .|.. ..|..| | |   ||| .| 
hlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqY
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1106-1276 5.5e-22 73.1 In-house 38-210 (255) alignment 
Range on Protein: 1106-1276
Range on HMM: 38-210/255.0
NATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNmdfiVQKNIMRRSFKVADSTG-KFAARTLTHYQYSQWAERGVPK
  | . |. . .| . | .||..   |  ..  . |.|.   . |..    .  |.       ... |  ..    | |  ..|..||.|  | |.  |.
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWieknaPe

SHVETYELMEMVKKSeKPIVVHCSNGIGRSMAFIGTEYLAR----QVEADPTIEL--TEALKHLHEHRWNGVQTNSQL
   |  ... .|..| |..|||||.||||| ||. .|.. .    ...  .|.||   . |..| ..|   ..|  ||
lareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlql
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1082-1277 2.4e-21 70.7 In-house 71-283 (301) alignment 
Range on Protein: 1082-1277
Range on HMM: 71-283/301.0
APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTN----MDFIVQK---------
  | |...    . ..|||.|.|.. |  ||| . .|. . .||||  . |  |.  . | |    .. ..| | ....|     ||....         
eyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgs

--NIMRRSFKVADSTgkfAARTLTHYQYSQWAERGV---PKSHVETY--ELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKH
  . . |.|||  .    ...... .|  .| . ||   |.  ..     ..   | .  |.|||||....||  ..  .    |. |.  ... .  | 
nngyierkfkvksdk...sswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtka

LHEHRWNGVQTNSQLY
.   .   |.|  |  
vrrskpgaVtTLeqyt
subfamily_CG7180_pd Subfamily CG7180 1084-1275 3.1e-21 70.3 In-house 73-278 (296) alignment 
Range on Protein: 1084-1275
Range on HMM: 73-278/296.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKnIHNDYLPMWPrnDLQVGRFMIKMTNMDFIvqKNIMRRSFKVADS---
| | .| .  ... .| |. | . | ..|| .  . |.. .|.. .. .. |   ..|.|       | | .........     |.  | ||.      
inavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqy..anlkirtfkltkkiva

------TGKFAARTLTHYQYSQWAE-RGVPKSHVETYELMEMVK----K-----SEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHE
        |   |.....|. .|     || |     ||...|.    |      |.|.||..|.| .|| .... .    .|| .  ... ||.| | .
lteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrr

HRWNGVQTNSQ
.| . |..  .
sRpqLvenvee
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1056-1275 6.8e-21 69.2 In-house 37-257 (281) alignment 
Range on Protein: 1056-1275
Range on HMM: 37-257/281.0
PEDKHRYPTVPCKPSTAVEVIV--DG--KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQ
 . | ||  .||   . |.. |          ||||.. .|   . .| || | . |  ||| |  | .   |||. . .|  ..   .|.|   .  ||
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcclq

VGRFMIKMtnMDFIVQKNIMRRSFKVADStGkfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
. .. ..    |  |.| ..   ....   |   .| .||. . .| .  ||.|     ...  ..    | |.||| |.||| ...  |   . . .  
fdklsvsy..edstvnkslvttrlnlsye.g..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialqsihshf

TI-ELTEALKHLHE-HRWNGVQTNSQ
|. .. . . ||.   |   |||  |
tlpdikqivshlrvtgraasvqtlqq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1031-1278 7.4e-21 69.1 In-house 22-270 (439) alignment 
Range on Protein: 1031-1278
Range on HMM: 22-270/439.0
YNTTIENVNVTTIDKDHITESYAY-LPEDKHRYPTVPCKPSTAVEV-IVD--GKRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVM
..   |..| |  |   |.   |    . | ||  |     | | .  .    .   | ||..     .. .|||| | . |..||| . ..  . .|||
fkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivm

VGRKVEYWKnihndylpMWPRNDLQV-GRFMIKMTNmdFIVQKNIMRRSFKVADSTGKF-AARTLTHYQYSQWAERGVPKSHVETYELMEMV-----KKS
.   || .|         || ..  . |  ....     |   | . | ||| .   .    ||. ...|  | .. ||       ...  .     |. 
ltnlvesyk........ywpsdaevcygdiavrvdr..nielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
  |.||||| |.||. . |  .    |. ..  ...   .| |...| . ||.  |  .
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1092-1278 1.4e-20 68.5 In-house 41-230 (237) alignment 
Range on Protein: 1092-1278
Range on HMM: 41-230/237.0
PGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRnDLQVGRFMIKMTNMDFIVQknIMRRSFKVADSTGKFAARTLTH
 | |...||.| |....|.||| |  |     |||.   .|  .    .| |   .     | . . ..  . . .     ||. ..  . .   | .  
dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq.paaygvltvslkkkeefsd..ytvrslllskrltlkevrlihq

YQYSQWAERGVPKSHVETYELM-EMVKKSEK-----PIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
||.. | .||||.       .  .....|..     | ..||| |.||.  |.  . . || .    ... . .. . | |   .||. |  .
yqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvf
0051082 (Phosphotyrosine protein) phosphatases II 1083-1278 4e-20 67.4 In-house 5-144 (151) alignment 
Range on Protein: 1083-1278
Range on HMM: 5-144/151.0
PIHANWVPTPghphrFIATQSPinatCEDFWAMCMQYEVEHIVMVGRKVEYWknihnDYLPMWPRNDlqvgrfmikmtnmdfivqknimrrsfkvadstg
.|....|        ..... |     .||...  .. . .||..  ..|.       .   .|...                                 
yinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.....ycpeylpelg.................................

kfaaRTLTHYQYSQWAERGVPKSHVETYELMEMVKKS-EKPIVVHCSNGIGRSMAFIGTEYLARQveadptIELTEALKHLHEHRWNGVQTNSQLYW
    ....|...  | . |.| |  .  |..|.. .  ..|..|||| |.||. ....   ....      . | |||......|.. ||.| | . 
....ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflf
0044763 (Phosphotyrosine protein) phosphatases II 1081-1280 4.5e-20 67.5 In-house 18-164 (178) alignment 
Range on Protein: 1081-1280
Range on HMM: 18-164/178.0
RAPIHANWVPtpghPHRFIATQSPinatcEDFWAMCMQYEVEHIVMVGRKVEYWkniHNDYLPMWP---Rndlqvgrfmikmtnmdfivqknimrrsfkv
  .|.|...     |. ..... |     .|....  .. . |||..   .|..   .....| ||                                  
sdyinaseil....pglylgslpp.....addlellkelgithivnlteelelg...flkcdpywpeeag..............................

adstgkfaartlTHYQYSQWAERGVPKSHVETYELMEMVK----KSEKPIVVHCSNGIGRSMAFIGTEYLARQveadpTIELTEALKHLHEHRWnGVQTN
             .|..  .   ||| .   ..|..|...    ....|..|||| |.||| ...   .. ..      . | ||.....|.|. .|.. 
............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.ivpnp

SQLYWMT
.||... 
gqlrqLy
0049772 (Phosphotyrosine protein) phosphatases II 1034-1279 4.9e-20 67.9 In-house 24-272 (314) alignment 
Range on Protein: 1034-1279
Range on HMM: 24-272/314.0
TIENVNVTTIDKDHITESYAYLPEDKHRYPTVPCKPsTAVEVivD-----GkRAPIHANWVPTPghpHRFIATQSPINATCEDF----------WAMC--
.. ... ... . .|. .. .|  || ||. ... . . | .  .     |  . |.|..| ..    .||||| | . |..||          | |   
vlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil..pglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlr

MQYEVEHIVM---------------------VGRKVEYWknihndylPMWPRNDLQVGRfmikmtnmdfivqknimrrsfKVADSTgKFAARTLTHYQYS
 .. |  |||                       .  ..         ....  ||.  .                     .. ..  ..  |.  .| . 
gdlnvrdivmsrdevladelsrLdaAlgKtpllildgng........neptaadlellk.....................eelydp.elferlgikylri

QWAERGVPkSHVETYELMEMVKK--SEKPIVVHCSNGIGRSMAFIGTEYLARQVeadpTIELTEALKHLHEHRW-----NGVQTNSQLYWM
 .   ..| .    .|..|....   ..|..|||. |.||.  |. . || ..      . | |||..... |      . ...  |....
pvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1093-1281 5.7e-20 66.5 In-house 49-235 (239) alignment 
Range on Protein: 1093-1281
Range on HMM: 49-235/239.0
GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFkVADSTGKFAARTLTHY
| |. .||||  ..... ||| |  |     |||.   .|  |.   .|   || .  .   . . . . .  |  . . |.| |    |.   | . .|
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy...wpdstskycnlrvtlrkte..vfadyiirtf.vmsqvgqteeryvyqy

QYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTL
... | ..|||.       |   . |      .| |.||| |.||. ||.  . . || . . |... . .| ..| |   |||. |  .. |
hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1093-1281 5.7e-20 66.5 In-house 48-234 (239) alignment 
Range on Protein: 1093-1281
Range on HMM: 48-234/239.0
GHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRFMIKMTNMDfiVQKNIMRRSFkVADSTGKFAARTLTHY
| |. .||||  ..... ||| |  |     |||.   .|  |.   .|   || .  .   . . . . .  |  . . |.| |    |.   | . .|
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy...wpdstskycnlrvtlrkte..vfadyiirtf.vmsqvgqteeryvyqy

QYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTL
... | ..|||.       |   . |      .| |.||| |.||. ||.  . . || . . |... . .| ..| |   |||. |  .. |
hftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
PTPc_DSPc_SM00012 1189-1276 2.6e-19 64.7 In-house 2-96 (105) alignment 
Range on Protein: 1189-1276
Range on HMM: 2-96/105.0
LTHYQYSQWAERGVPKSHVETYELMEMVKKSEK------PIVVHCSNGIGRSMAFIGTEYLARQVEAD-PTIELTEALKHLHEHRWNGVQTNSQL
..||.|..| . |||..  .  ||.. |||...      |.|||||.|.||.  |.  ..| .|.|.   .... . .|.| ..| . |||. | 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
subfamily_hpo-7_pd Subfamily hpo-7 1107-1276 3.3e-19 63.8 In-house 45-216 (263) alignment 
Range on Protein: 1107-1276
Range on HMM: 45-216/263.0
ATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFivqkNIMRRSFKVADSTG-KFAARTLTHYQYSQWAERGVPKS
 | . |. .  | . | .||..   |  ..  . |.|.   . ...    .  |..      ... .. ..    | |   .|..||.|  | |.  |. 
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndpel

HVETYELMEMVKKSeKPIVVHCSNGIGRSMAFIGTEYLAR----QVEADPTIEL--TEALKHLHEHRWNGVQTNSQL
  | .........| |..|||||.||||| ||  .| . .    ...  .|.||   . |..| ..|   ..|  ||
areilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqL
subfamily_PTPRN_pd Subfamily PTPRN 1097-1277 7.7e-19 62.5 In-house 101-282 (297) alignment 
Range on Protein: 1097-1277
Range on HMM: 101-282/297.0
RFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGR-FMIKMTnMDFIVQKNIMRRSFKVADSTGKfAARTLTHYQYS
 .||||.|...|  ||| |  .  |  ||.. |  |   .  . |   || .  .|   . ...   . |  .. . ||| . .   .  .||.| . . 
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckry...wpdeGsevyhiyevhlv.sehiwcddylvrsfylknlqts.etrtvtqfhfl

QWAERGVPKSHVETYELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYL-ARQVEADPTIELTEALKHLHEHRWNGVQTNSQLY
 | |.||| |     |.   | ||      |||||||.| ||. ..|  . . .| .     |... .|.|| . | . |.|..|. 
swpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe
subfamily_egg_pd Subfamily egg 1042-1252 8.4e-19 62.4 In-house 26-233 (307) alignment 
Range on Protein: 1042-1252
Range on HMM: 26-233/307.0
TIDKDHITESYAYLPEDKHRYPTVPCKPSTAVEVIV-DGKR--APIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYwkNIH
..|.  .|....    .| | . |.|| |. |.. .  |.     |||| |        || .|.|.  | .||| | .| ||..|||.  ..|   .  
svdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

NDYlpmWPRNDLQVGRF---MIKMTNMDFIVQKNIMRRSFKVADSTGKFAARTLTHYQYsQWAERGvpKSHVeTYELMEMVKKSEKPIVVHCSNGIGRSM
. |   ||. . .  ..    ....|..   . . . |  |.    |.   | | |.|. .. . .  . .   .... ....  ||.||.. .|. .. 
eyy...wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerflehwqg.dvnnss..dvys.plrvlrklrnlskpvvvqdilGvskaa

AFIGTEYLARQVEADPT
...  |    ..   |.
tlvaieiallsllrGpi
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1058-1279 9.3e-18 58.8 In-house 54-282 (310) alignment 
Range on Protein: 1058-1279
Range on HMM: 54-282/310.0
DKHRYPTVPCKPSTAVEVIVDGKRA--PIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRNDLQVGRF
 | ||  | |. .. | . .|  |    ||||.| |      || .| |.. |  ||| | .|   | |... . .|  .     |   ||   .     
hknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgy...wpslgvtetyg

MIKMTNMDFIVQK--------NIMRRSFKVADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQV
 |..||.    ..         ..     | .   ..    ..  .. .| .||||  .. |     . .    | ||||| |..|  . .  ..   ..
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkl

EADPTIELTEALKHLHEHRWNGVQTNSQLYWM
.    ... |   .|. .|   .||. |  ..
drglkvdaeevktellksraiciqtelqylii
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1035-1276 5.3e-17 56.7 In-house 12-248 (267) alignment 
Range on Protein: 1035-1276
Range on HMM: 12-248/267.0
IENVNVTTIDKDHITESYAYLPEDKHRYPTVpcKPSTAVEVIVDGKRAP-IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKveY
 |...  . ..  |. |.|   ....|.  .   |     ||.  |    | | .| .    . ||.|| |.. |  ||. . ....|  ||.. .   .
felikkisdtsstisqsiaeknqernrlddn..lpyddtrvilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkv..f

WKNIHNDYLPM----WPRNDLQVGRFMIKMTNMDFIVQKNImrrSFKvaDStgkfAARTLTHYQYSQWAERGVPKSHVETYE-L--MEMVKKSEKPIVVH
  ||.  . |        .|| | . . |  |   |.  ..    ||  .     .|. .| | | .|      | ...    .   . ... ..|.||.
tdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfk..ne....sahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvva

CSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQL
||.|.||| .|.  .   ...  . . .. . |... . |   |.|  . 
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1103-1283 2.4e-16 54.1 In-house 98-284 (302) alignment 
Range on Protein: 1103-1283
Range on HMM: 98-284/302.0
SPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMRRSFKVA------DSTGKFAARTLTHYQYSQ
 | . |.| .||.  ||.|  .| .   ||  ..   .|     .. |. ||. .|  ...  ...   ..|||.       . . |   .|.   ..| 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYWMTLGT
| . | ||    . ...   .   | ..||||.|.||. ...   |       . . .| . .. . . |.  ||...|| .. |  
wpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
0048076 (Phosphotyrosine protein) phosphatases II 1161-1280 3.7e-16 54.6 In-house 21-136 (145) alignment 
Range on Protein: 1161-1280
Range on HMM: 21-136/145.0
NMDFIVQKNIMR-RSFkvaDSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMV---KKSEKPIVVHCSNGIGRSMAFIGTeYLARQveadPTIELT
..... . .| .  ..    |. ..  |. ..|.|  |  .||| ..   .|..|..    |...|..|||| |.||. ....  || ..      . | 
dlellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa.ylmll....lgvsle

EALKHLHEHRWNGVQTNSQLYWMT
|||......|...|.. .||... 
ealelvrsqrpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1096-1266 4.5e-16 53.6 In-house 4-182 (198) alignment 
Range on Protein: 1096-1266
Range on HMM: 4-182/198.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkvEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNI--MRRSFKVADSTGKFAARTLTHYQ
.|.|||| |.  |  ||| |  .    |||||    .  ||   ||  .||  .  .|..         |. |    .     . ..|   ..| ..|||
rryiatqhplretladfwqmvwetgsghivmvn...ddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YSQWAERGVPKSHVETY---ELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT--IELTEALKHLHEHR
.. | |.  |.  .         |. || |     |..||||.| | .  |.  .   |  |   |  ..| |  | | . |
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1096-1266 4.9e-16 53.5 In-house 5-183 (199) alignment 
Range on Protein: 1096-1266
Range on HMM: 5-183/199.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGrkvEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNI--MRRSFKVADSTGKFAARTLTHYQ
.|.|||| |.  |  ||| |  .    |||||    .  ||   ||  .||  .  .|..         |. |    .     . ..|   ..| ..|||
rryiatqhplretmadfwqmvwetgsghivmvn...ddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

YSQWAERGVPKSHVETY---ELMEMVKKSE----KPIVVHCSNGIGRSMAFIGTEYLARQVEADPT--IELTEALKHLHEHR
.. | |.  |.  .         |. || |     |..||||.| | .  |.  .   |  |   |  ..| |  | | . |
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqar
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1059-1278 5.8e-16 52.9 In-house 48-227 (392) alignment 
Range on Protein: 1059-1278
Range on HMM: 48-227/392.0
KHRYPTVPCKPSTA--VEVIVDG-KRAPIHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWknihndylpmwprndlqvgrf
| ||  .    |.   .||| |  ..  . | ..|.    . .||.|.|  |. .||| | .| .|  |.|| .  |                       
knryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....................

mikmtnmdfivqknimrrsfkvadsTGKfAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADP
                          |.  ||| . .....| ...|||      .... ||       .|...||| |.||.   |  . .  . .   
.........................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktr

TIELTEALKHLHEHRWNGVQTNSQLYW
 ... . .  ....|   |||. |  .
mvdvfnfvtnirrkrpymvqtkeqyaf
0048179 (Phosphotyrosine protein) phosphatases II 1177-1279 4.7e-15 51.1 In-house 37-137 (144) alignment 
Range on Protein: 1177-1279
Range on HMM: 37-137/144.0
VADSTGKFAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS---EKPIVVHCSNGIGRSMAFIGTEYLArqveaDPTIELTEALKHLHEHRWNGVQTN
. .    |  |. ..|..  |  .||| .    .|..|....    ..|..|||| |.||. ...    .         . | |||......|...|.. 
teeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnp

SQLYWM
.||...
gqlrfL
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1079-1204 1.4e-12 42.1 In-house 57-181 (297) alignment 
Range on Protein: 1079-1204
Range on HMM: 57-181/297.0
GKRAPIHANWVPTPG--HPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIKMTNMDFI-VQKNIMrRSF
 .|  | |..|  |   .. ..| .| |..|| .||| . .. .|  |||| .  |  ..    | |    . |. | ....         .. |.   .
terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.tel

KVADStgkFAARTLTHYQYSQWAERGVPK
..         | ..| |.  | . ||| 
qliyr...sesrvvrhvqflswpdhGvps
subfamily_ptpA1_pd Subfamily ptpA1 1084-1241 1e-11 39.2 In-house 78-250 (418) alignment 
Range on Protein: 1084-1241
Range on HMM: 78-250/418.0
IHANWVPTpGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVE--------YWK-NIHNDYLPMWPRNDLQVGRFMIKMTNMDFIVQKNIMRRS
| ||..    .|..||.|| |.  |  ||| |  .  .  |||. |. |        ||  .|  . . ..   .  .| . ... ..    ...|. | 
inanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrn

FKVadsTGKFAARTLTHYQYSQWAERGVPKSHVETYELME--------MVKKSE--KPIVVHCSNGIGRSMAFIGTE
 ..   | .  .| .|.|||  | .. .|       .|.         ..  |.   ||.|||| |.||. .|  . 
irl...tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1047-1291 9.7e-10 32.5 In-house 38-278 (303) alignment 
Range on Protein: 1047-1291
Range on HMM: 38-278/303.0
HITESYAYLPEDKHRYPTVPCKPSTAVEViVDgkRAPIHANWVPTPGHpHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKnIHNDYlpMWP
...        || |.  | |   . |..  |   . |||...    . .. | || |.. |. ||| | ..  |  ....    || | .  |.  ..|
svsknqfvknmdknrfvdvicldhskvkl.sd..ssyihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvlllltdseydk.lggds..vfp

RND--LQVGRFMIKMTNMdfiVQKNIMRR-SFKV-ADSTGKFAARTLThYQYSQWAERGVPKS-----HVETYELMEMVKKS--EKPIVVHCSNGIGRSM
||.  |.    .|.. ..    . ...   ..|| . | |.. .     ..| .|    .|         . ..|  ...|    .| |     | ||. 
rnqdflkfeersirvgef...krvelgdgwvlkvlsvsngdyksflhv.hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgrag

AF--IGTEYLARQVEaDPTIELTEALKHLHEHRWNGVQTNSQLYWmtlgtMYRLIKEY
.|  . | .|. . | .....|   |. . . |   ||  ||.       .| |. |.
tfalfetahlslhse.qasldlvkclenvrngrlhavqnlsqfsv.....vytllaeh
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1184-1280 3e-09 30.7 In-house 86-187 (440) alignment 
Range on Protein: 1184-1280
Range on HMM: 86-187/440.0
FAARTLTHYQYSQWAERGVPKSHVETYELMEMVKKS-----EKPIVVHCSNGIGRSMAFIGTEYLARQVEADPTIELTEALKHLHEHRWNGVQTNSQLYW
  .||| .|.|  | ..||||      .... |..|     . |..|||| | ||.   |  . . |...    |..   .. ... | . |||  |  .
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

MT
. 
vh
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1096-1162 3.9e-09 30.7 In-house 104-165 (350) alignment 
Range on Protein: 1096-1162
Range on HMM: 104-165/350.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYlpmWPRndLQVGRFMIKMTNM
...||||.|.  | .||. .... .|. |...  .||.  .  . |   |..  ...  . .|....
fkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrY...Wqe..gsydditvklask
subfamily_CG42327_pd Subfamily CG42327 1060-1208 2.2e-08 28.1 In-house 32-182 (319) alignment 
Range on Protein: 1060-1208
Range on HMM: 32-182/319.0
HRYPT-VPCKPST--AVEVIVDGKRAPIHANWVPTPGHP-HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRF
 |.   ||  ..     ..  | |   ..|..|  .      .||.| . . .  ||| .  .     || .    |   .   .|||     | .    
srvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntslyG

MIKMTNMDFIVQKNiMRRSFKVADSTGKFAARTLTHYQYsQWAERGVPKSHVE
 |..|  .  |...    |  .     |  .| |||| | .| | .|| ..  
dilvtlkgrevkdr.yaistlllkrvdkeesrelthywy.kwleaevPaeeaa
subfamily_eak_pd Subfamily eak 1096-1231 2.2e-08 27.9 In-house 93-222 (332) alignment 
Range on Protein: 1096-1231
Range on HMM: 93-222/332.0
HRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRKVEYWKNIHNDYLPMWPRNDLQVGRFMIkmTNMDFIVQKNIMRRSFKVadSTGKFAaRTLTHYQYS
...| |  . .     || | ..     ||..  .||   . .. |.|   |. |. | . .  .  .|. ....  | ...  | |  .   . ||.. 
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGildv..erkefvkrniletrllel..skGnet.hrvlhykvf

QWAERGVPKSHvETYELMEMVKKSEKPIVVHCSNGI
 |.|  .|| . .   | ...|.   . ..   . .
Gwtettlpkye.dflalrkvmkevGvlllivmksal
TMEM154 TMEM154 protein family 811-871 2.1e-07 22.4 Pfam-A 37-99 (146) alignment 
Range on Protein: 811-871
Range on HMM: 37-99/146.0
AAAVGSSTVSTVSDES--SDFpILFVVIP-VVLILVALVIggIVFIWYRKREEKRKE--KEAEEEN
.| |... ..   ...   .. .| ..|| |||||. ||.  .... ..||  ...|  .| |.|.
sanvnleegelseksadqael.vlmiiiPsvvLillllvv..vilvikkkrkrrKqeetsedeked
PTPc_motif_SM00404 1191-1274 8.8e-07 23.9 In-house 51-128 (140) alignment 
Range on Protein: 1191-1274
Range on HMM: 51-128/140.0
HYQYSQWAERGVPKSHVETYELMEMVKKSEKPIVVHCSNGIGRSMAFIGTEYLARQveadpTIELTEALKHLHEHRwNGVQTNS
... ..  .  . |   .... .| ..|... ..|||  |. || ..|  ... ..      ..| ||.. ..| | . .. | 
qiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr.....qlslaeayefvkerR.piispnl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1084-1203 1.9e-06 21.7 In-house 125-237 (244) alignment 
Range on Protein: 1084-1203
Range on HMM: 125-237/244.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRkVEYWKNIHNDYLPM-WPRNDLQVgrfmiKMTNMDfiVQKNIMRRSFKVaDSTG
| | .|   |    .| || |.  |  ||| | ..  |. .|..|  ||   .   |  |. |  .|. |      .|. |    |||    ... .|  
inasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs.veeedeywpdseplewyeeditv.....tltdrd..efknikasnlei.esdm

KFAARTLTHYQYSQWAERGV-P
. . ..|| .| |.|   |  |
neshqaltmfqisnwpsdgttp
subfamily_CG42327_pd Subfamily CG42327 1217-1278 2.2e-06 21.6 In-house 244-306 (319) alignment 
Range on Protein: 1217-1278
Range on HMM: 244-306/319.0
KKSEKPIVVHCSNGIGRSMAFIGTEYLARQVEAD-PTIELTEALKHLHEHRWNGVQTNSQLYW
..|  |.|||||.|.||.   | ..   |..|    .... . . .. . | . |.|  |  .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef
DUF1510 Protein of unknown function (DUF1510) 831-943 2.5e-06 16.3 Pfam-A 15-125 (217) alignment 
Range on Protein: 831-943
Range on HMM: 15-125/217.0
ILFVVIPVVLILVALVIGGIVFIWYRKREEKRKEKEAEEENEKLIAERERMRAIKEEEeRVKAEREK-----VKKEEERLKAEEEKVKVEKernkekVKA
.| . | .|..|...| . ... .  .......|.|.|.....  .| |..   ..|.   ....|.      |.||.. ..|||| |.|.       . 
vLniaiaiVvvlivivaaqllvgnskskkasadeeeeeksedeekteeeevkeeekea.akdedkeddsesekkdeeseeeeeeekekkee......ese

EEERLKAEEEKVKIEKEK
|.|. ..|.|. ..||| 
edeketeekeesnvekei
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1084-1201 2.8e-06 21.7 In-house 16-125 (130) alignment 
Range on Protein: 1084-1201
Range on HMM: 16-125/130.0
IHANWVPTPGHPHRFIATQSPINATCEDFWAMCMQYEVEHIVMVGRkVEYWKNIHNDYLPM-WPRNDLQVGrfMIKMTNMdfivqKNIMRRSFKVADSTg
|.|..|   |.   .. || |. .|. ||| | ..  |. .|..|  ||   .   |  |. |  .|. |   . .  ..     |||    ... .   
inasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veeedeywpdsePlewyeediivt..ltdrdef.....knikasnleiesdl.

KFAARTLTHYQYSQWAERG
. . ..|| .| |.|   |
neshqaltmfqisnwpsdg
DUF3377 Domain of unknown function (DUF3377) 818-857 5.6e-06 16.1 Pfam-A 18-57 (74) alignment 
Range on Protein: 818-857
Range on HMM: 18-57/74.0
TVSTVSDESSDFPILFVVIPVVLILVALVIGGIVFIWYRK
.| .|.|.|.   .. ||||.|| |  ||.   ..   ||
ivvevddvsgtvnavaVviPlvLalCiLvlvytivqfkrk
MFS_1 Major Facilitator Superfamily 805-877 5.8e-06 11.5 Pfam-A 127-189 (352) alignment 
Range on Protein: 805-877
Range on HMM: 127-189/352.0
GTGTGAAAAVGSSTVSTVSdESSDFPILFVVIPVVLILVALviggiVFIWYRKREEKRKEKEAEEENEkliaE
..|....|..|    . .. .|  .. .|... .|..|.|.     .|...  .|..........| |     
sagfslGailgpllgglla.sslgWravfyilaivsllaav.....lfllllpeepperkrkspkeee....g
DUF2763 Protein of unknown function (DUF2763) 742-811 6.7e-06 13.0 Pfam-A 19-86 (91) alignment 
Range on Protein: 742-811
Range on HMM: 19-86/91.0
QNVPSAFQSFDNFLQLFFASQQTISVPPPNPQSNSGGVNTGGTGNGNGSGGpsGDTGTGPTGSGTGTGAA
. .   | .. .|..||| .   . |  .. ...| . .  ... |.| .|  |  . |. | | |  | 
siivdfflgilefislFFrtllspevekarrknssskkkiddgrGgpgapg..Ggrrlgrigggggpsap