Gene Y39B6A.30 in Caenorhabditis elegans

Synonym: CELE_Y39B6A.30, CELE_Y39B6A.30

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily CelePTP-sf19
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP215_AA protein Get Run
CeleP215_AA_1055-1350 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1054-1358 1.3e-180 593.8 In-house 2-300 (301) alignment 
Range on Protein: 1054-1358
Range on HMM: 2-300/301.0
KRKIIEKWIMSKDYKDDQRTAKFCNTTIESVNASTIDKDHITESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQRVPIHANWIPTPGHPHRFIATQGPLTN
|.| |||||.|||.|||..||||.|||||.||..|||||||||||.|||.||||.|.|||||||||||||||.|||||||||||.|||||||||||||.|
kvkkiekwiiskdfkdddktakfynttienvnvttidkdhitesyaylpkdkhryptvPckPstavevivdGkrvPihanwiptsGhphrfiatqgPlkn

TCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFPflsktkNQLKIGRFEIKIKNTEYILNKKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYG
|.||||.||.|||||.|||.|||.|.|...|..|.|....      ..|.||||.|||||.|.||||||..|||||.||||||||||..|||||||| .|
tsedfwamlvqydvekivmlgqkvekleekceeylpvkis......ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrg

VPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWMTLGTMYRLIKEYGFDMKMYEKQ
|||||||||||||.|||||||||||||.|||||.||||||.|||||||||||||||||||.|||||||||||||||||||||.||||||||||||.||.|
vPkshaelfdlmelvkksekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlikeygfdmkiyeeq

MAMFT
.|||.
lamfd
0036941 (Phosphotyrosine protein) phosphatases II 1104-1357 2e-66 219.6 In-house 41-294 (297) alignment 
Range on Protein: 1104-1357
Range on HMM: 41-294/297.0
DKHRFPNVPCKPSTAVEViVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLK
.|.|...... ..| | .  |.    |.|...........|||||||| ||.|||| |.....|..|||. .  |.   .|  |.|      ... . |.
eknRykdilpydhtRVkl.ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp......leegeslt

IGRFEIKIKNTEYILNKKINQRTLEVVDStGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK------SEKPIVVHCSNGIGRSMAFIGTECLAR
 |.| .. ...|..|.. . .|||||.|  |.  .||..|..|  |  .||| |.|.|.|..| |.|      |..|..||||.|.|||..||. ... .
ygdftvtllsvevvllddytlrtlevtdt.gngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlq

EVE---ADPTIELTEALKHVREHRWNGVQTNSQLYWMtLGTMYRLIKEYGFDMKMYEKQMAMF
 .|     ... . ||.|..||.|.. ||| .|....   ... |.| . ... .... ....
qledklkeggvdileavkklReqRpgavqtleqyrfl.yeallellkkkltkepllklvllll
0040438 (Phosphotyrosine protein) phosphatases II 1088-1344 1.2e-64 213.9 In-house 29-276 (317) alignment 
Range on Protein: 1088-1344
Range on HMM: 29-276/317.0
TIDKDHITESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQRVP---IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMC
....|...... .   ||.|.|.... ... | . ..| . .   |.|.....| ....|||||||| ||.|||| |.....|..|||. .  |.   .|
slkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekc

TDYFPLwfpflsktKNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDStGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCS
  |.||        .. |..|.| ......|.  .. |. |||||.|. |.  .||..|..|  |. .|||.|. .|.|..|.|...    ..|..||||
aqYwpl........getltygdftvtllseee..lagitlrtlevedl.gdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCs

NGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWMtlgtmYRLIKEYG
.|.||...||. ... . .|   .. ..||.|..||.|...||| .|....     |... || 
aGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrfl.....ydalleyl
0045450 (Phosphotyrosine protein) phosphatases II 1052-1330 1.8e-60 200.6 In-house 8-295 (307) alignment 
Range on Protein: 1052-1330
Range on HMM: 8-295/307.0
KEKRKIIEKWIMSKDYKDDQRTAKFCNttiESVNASTIDKDHITESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQRVP----IHANWI--------PTPG
............ .  .. .. .|  .   . ..  ... ....... .   ||.|...... ..| | . . .....    |.|...        ... 
fidalkllllvllllldfltgllkefe...kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

HPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWfPFLSKTKNqlkigrFEIKIKNTEYilNKKINQRTLEVVDSTGKFATR
....|||||||| .|.|||| || ...|..|||  .  |.   .|  |.|.        .|      | .. ...|.   ...  ||||| |. |.. .|
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygn......ftvtllseeh..ldgytvrtlevtdldgtgesr

TLMHYQYSEWTGYGVPKSHAELFDLMEIVKK------SEKPIVVHCSNGIGRSMAFIGTECLAREVEADPT---IELTEALKHVREHRWNGVQTNSQLYW
|..|..| .| ..|||.| .||.|..|.|.|      ...|..|||| |.||...||.   . | .|...|   . | ||.|..||.|...||. .|...
tvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrf
0050432 (Phosphotyrosine protein) phosphatases II 1093-1331 6.8e-60 198.3 In-house 59-291 (308) alignment 
Range on Protein: 1093-1331
Range on HMM: 59-291/308.0
HITESYTYLPEDKHRFPNVPCKPSTAVEVivDGQRVPIHANWIPTP--GHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPL
 .. ..     ||.|......  .. | .  |.    |.|......  ..|..|||||||| ||.|||| |.....|..|||. .  ||    |  |.||
eysvallpenkdkNrykdilpydhsRVkl..degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwpl

WFpflsktK-NQLKIGRFEIKIKNTEYilNKKINQRTLEVVDSTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS--EKPIVVHCSNGIGRSM
        . . |..|.| ......|   .. . .||||.... ..  .||..|..|  |  .||| | ..|.|..|.|.||  ..|||||||.|.||..
el......gggsleygkftvtllseev..lddytvrtleltnlgdg.esrtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtG

AFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
.||  ..| . .|.. .. . ||.|..||.|.. ||| .|....
tfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl
0039614 (Phosphotyrosine protein) phosphatases II 1088-1331 9.9e-58 191.3 In-house 45-281 (297) alignment 
Range on Protein: 1088-1331
Range on HMM: 45-281/297.0
TIDkdhITESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQ----RVPIHANWIPTPGH-PHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTd
..|   ..... .   ||.|...... ... | . . .        |.|...... . ...||||||||..|.|||| |. ...|..|||  .  |.   
kpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.

MCTDYFPLWFPflsktknqlKIGRFEIKIKNTEYilNKKINQRTLEVVDsTGKFatRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK------SEKPIV
.| .|.|             . |.| .. ...|.  .. ...|||||.. .|.   ||..|.||  |  .||| |.. |....|.|..      ...|..
kcaqywpeegg.........tygdftvtllkveh..ldgytvrtlevtn.nges..rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvl

VHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
||||.|.||. .||.   . . .|   .. . ||.|..||.|...||| ||... 
VHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfl
0043336 (Phosphotyrosine protein) phosphatases II 1086-1330 2e-57 190.2 In-house 29-268 (278) alignment 
Range on Protein: 1086-1330
Range on HMM: 29-268/278.0
ASTIDKDHITESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQRVP---IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTD
  ....|... .. .   ||.|...... ... | . ..| . .   |.|...... .|..||||||||..|.|||| |. ...|..|||  .  |.   
llsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrv

MCTDYFPlwfpflsktKNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDsTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK----SEKPIVVH
 |  |.|         .. |..|.| .. ...|.  .. . .|||||.. .|.  .|| .||.|  |  .||| | . |.|....|..    |..|..||
kcaqYwp.........ggsltygdftvtllkeeh..lddytvrtlevtn.lgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVH

CSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
||.|.||...||. . | . .|   .. | ||.|..||.|.. ||| ||...
CsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrf
0047943 (Phosphotyrosine protein) phosphatases II 1101-1331 4.4e-57 189.0 In-house 37-264 (273) alignment 
Range on Protein: 1101-1331
Range on HMM: 37-264/273.0
LPEDKHRFPNVPCKPSTAVEViVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWfpflskTKN
   ||.|......  .. | .  ||    |.|...... ....|||||||| ||.|||| |.....|..|||  .  |.    |  |.||.        .
enkdknrykdilpydhsrvkl.gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwple......gge

-QLKIGRFEIKIKNTEYilNKKINQRTLEVVDSTGKFaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK------SEKPIVVHCSNGIGRSMAFIGTE
  |. |.| ......|.  .. . .||||....  .  .|| .|..| .|  .||| | ..|....|.|.|      |..|.|||||.|.||...||  .
lsltygkftvtllseet..kddytvrtleltnlgtge.srtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfiald

CLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
.| . .|.  .. . ||.|..|..|...||| .|....
llldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 1095-1331 8.9e-56 184.8 In-house 42-278 (288) alignment 
Range on Protein: 1095-1331
Range on HMM: 42-278/288.0
TESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQ---RVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLw
. ..     .|.|......  .. | . | ..      |.|..|... ....|||||||| ||.|||| |.....|..|||. .  |.    |  |.|| 
saallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.

fpflsktKNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDST---GKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCSNGIG
       .. |..|.. ......|   .... .|||||.. .   |.  .|| .|..|  |  .||| |  .|.|....|.|.    ..|.|||||.|.|
.......ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvg

RSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
|...||  ..| . .|.  .... ||.|..||.|.. ||| .|... 
RtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfv
0046845 (Phosphotyrosine protein) phosphatases II 1098-1331 2.6e-55 183.2 In-house 24-266 (284) alignment 
Range on Protein: 1098-1331
Range on HMM: 24-266/284.0
YTYLPEDKHRFPNVPCKPSTAVEVIVDGQR----VPIHANWIPTP-----GHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYF
. .   .|.|......  .. | . . ...      |.|......      ....|||||||| ||.|||| |.....|..|||. .  ||   .|  |.
llpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYw

PLWfpflsktKNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS------EKPIVVHCSNG
||.       .. |..|.| ......|.  .. . .||||...   .  .||..|..| .|  .||| | . |......|...      ..|||||||.|
ple.......gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaG

IGRSMAFIGTECLAREVEADP---TIELTEALKHVREHRWNGVQTNSQLYWM
.||...||  ..| . .|..    .. . ||.|..||.|.. ||| .|... 
vgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfv
Y_phosphatase Protein-tyrosine phosphatase 1104-1331 3e-55 182.6 Pfam-A 3-229 (235) alignment 
Range on Protein: 1104-1331
Range on HMM: 3-229/235.0
DKHRFPNVPCKPSTAVEV-IVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQL
.|.|......  .| |..   .|.   |.||.. .  ....|||||||| .|.|||| |..|..|. |||  .  |.    | .|.|      ......|
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeeeesl

KIGRFEIKIKNTEYILNKKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECLARE
. |......|. |   .|... |.||. ..... ..|......| .|. .|||.|  .|.||.. |.||.    .|.|||||.|.||.. |.  ..| ..
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VEADPTIELTEALKHVREHRWNGVQTNSQLYWM
.||. .... ...|..|..| . ||. .|....
leaeeevdvlqivkelRkqRpgmvqsleqYifl
Y_phosphatase Protein-tyrosine phosphatase 1104-1331 3e-55 182.6 In-house 3-229 (235) alignment 
Range on Protein: 1104-1331
Range on HMM: 3-229/235.0
DKHRFPNVPCKPSTAVEV-IVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQL
.|.|......  .| |..   .|.   |.||.. .  ....|||||||| .|.|||| |..|..|. |||  .  |.    | .|.|      ......|
kknRykdilpydktrvklkgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp......eeeeesl

KIGRFEIKIKNTEYILNKKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECLARE
. |......|. |   .|... |.||. ..... ..|......| .|. .|||.|  .|.||.. |.||.    .|.|||||.|.||.. |.  ..| ..
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

VEADPTIELTEALKHVREHRWNGVQTNSQLYWM
.||. .... ...|..|..| . ||. .|....
leaeeevdvlqivkelRkqRpgmvqsleqYifl
DSPc_SM00195 1081-1331 7.7e-55 181.4 In-house 6-254 (263) alignment 
Range on Protein: 1081-1331
Range on HMM: 6-254/263.0
IESVNASTIDKdHITESYTYLPEDKHRFPNVPCKPSTAVEVIVDG---QRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKR
.|....|| .| ..||.     ..|.|. |...  .| |..  .    .   |.||.| .. .....||||||| .|.|||| | .. .|. |||. .  
fekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ENLTDMCTDYFPLWFpflsktKNQLKIGRFEIKIKNTEYILnKKINQRTLEVVDSTGkFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEK----
||    |..|.|         ... ..|....|....|    ..|..||||.   .    ||.. .||| .|.  |||.|. ....|.. ||||..    
engkekcdrywpees......ggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

PIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
|||||||.|.||. .|. .... ...|.. .... | .|..|..| . |||  |. ..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
PTPc_SM00194 1081-1331 7.7e-55 181.4 In-house 6-254 (263) alignment 
Range on Protein: 1081-1331
Range on HMM: 6-254/263.0
IESVNASTIDKdHITESYTYLPEDKHRFPNVPCKPSTAVEVIVDG---QRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKR
.|....|| .| ..||.     ..|.|. |...  .| |..  .    .   |.||.| .. .....||||||| .|.|||| | .. .|. |||. .  
fekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteee

ENLTDMCTDYFPLWFpflsktKNQLKIGRFEIKIKNTEYILnKKINQRTLEVVDSTGkFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEK----
||    |..|.|         ... ..|....|....|    ..|..||||.   .    ||.. .||| .|.  |||.|. ....|.. ||||..    
engkekcdrywpees......ggketfgkisvklvevekkk.deiilrtleltkegk.eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

PIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
|||||||.|.||. .|. .... ...|.. .... | .|..|..| . |||  |. ..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfi
0040439 (Phosphotyrosine protein) phosphatases II 1094-1330 2.5e-54 179.8 In-house 3-237 (249) alignment 
Range on Protein: 1094-1330
Range on HMM: 3-237/249.0
ITESYTYLPEDKHRFPNVPCKPSTAVEVIVDGQRVP---IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPL
..... .   ||.|.|.... ... | . . . . .   |.|..|... ...|||||||||..|.|||| || ......|||. .  |.    |  |.||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

wfpflsktKNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDStGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK------SEKPIVVHCSNGIG
        .. |..|.| .. ...|.  .... .||||.... ..  .|| .|.||  |  .|||.| ..|.|..|.|.|      ...|..||||.|.|
........ggsleygdftvtllsvev..kddytvrtleltnl.ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvg

RSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
|. .||.   . . .|   .. | ||.|..|..|...||. .|...
RtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrf
0042113 (Phosphotyrosine protein) phosphatases II 1102-1331 4.5e-54 178.8 In-house 9-235 (245) alignment 
Range on Protein: 1102-1331
Range on HMM: 9-235/245.0
PEDKHRFPNVPCKPSTAVEVIVDGQRV---PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpflskt
  ||.|...... ..| | . .|| .    .|.|...... ....||||||||..|.|||| || ......|||. .  |.    |  |.||        
nkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl........

KNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDsTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK-----SEKPIVVHCSNGIGRSMAFIGTE
.. |..|.| .. ...|.  .... .|||||.. .|.. .|. .||.|  | ..||| ... |.|..|.|.|     |..|..|||| |.||...||.  
gesltygdftvtllseeh..lddytvrtlevtn.lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

CLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
 ... .|.  .. | ||.|..|..|.. ||| ||....
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl
0045098 (Phosphotyrosine protein) phosphatases II 1093-1331 3e-51 169.8 In-house 24-264 (278) alignment 
Range on Protein: 1093-1331
Range on HMM: 24-264/278.0
HITESYTYLPEDKHRFPNVPCKPSTAVEvivDgqrvPIHANWIPTPghPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwf
 ||..    . ||.|...... ... |    |     |.|..|...  |..|||||||| .|..||| || ......|||  .  |.    |  |.|   
eitpalylgnldknRykdilpydhsrVk...d....YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp...

PflsktKNQLKIGRFEIKIKNTEYIlnKKINQRTLEVVDS---TGKFATRTLMHYQYSEWTGYGVPKSH--AELFDLMEIVKK-----------------
.     .. | .|.|.......|..  ...  |||.|..       . .|.. |..|  |  .||| ..  . ...|.| ...                 
e.....ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

SEKPIVVHCSNGIGRSMAFIGTECLAREVeaDPTIELTEALKHVREHRWN-GVQTNSQLYWM
|..|..|||| |.||. ....  .. . .  .... | ||.|..|..|..  ||. .|....
sggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrfl
0037934 (Phosphotyrosine protein) phosphatases II 1100-1330 2.4e-46 153.6 In-house 8-233 (243) alignment 
Range on Protein: 1100-1330
Range on HMM: 8-233/243.0
YLPEDKHRFPNVPCKPSTAVEVivDGqRVPIHANWIPTPGhphRFIATQGPLTNTCED----FWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpfl
.   .|.|...... . . | .  .|    |.||.|. ..   |.|||||||..|.||    || || ......|||. .  |.    |  |.|      
penlsknrysdilpydhsrvkl..eg.sdyinanliyvtp...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp......

sktkNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVK------------KSEKPIVVHCSNGI
    ..  .|.|.......|.   ... .|||...    .  ||. .||.|  | ..||| |.. | |....|.            .|..|..|||| |.
....gevtygdftvtllseeh..lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSMAFIGTECLAREVeadpTIELTEALKHVREHRWN-GVQTNSQLYW
||. ..|    . . .    .. | ||.|..||.|.. .||| ||...
gRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrf
subfamily_PTPRD_pd Subfamily PTPRD 1130-1329 7.7e-41 135.3 In-house 79-271 (564) alignment 
Range on Protein: 1130-1329
Range on HMM: 79-271/564.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflskTKNQLKIGRFEIKIKNTEYIlnKKINQRTLEV
| |..| .  ... .||||||| .|.|||| |....... |||  . .|. .. | .|.|        .|.. ..|.........| .  ...  ||...
INAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWP........ekgtetygeltVtleeeeel..adyeirtfkl

vDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTN
   . .  .|.  .... .|   |||.| ..| ||.. |...    ..|||||||.|.||. .||  ... . .... |... . .|..|..|   |||.
.kkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte

SQLY
.|  
eQYi
subfamily_PTPRB_pd Subfamily PTPRB 1089-1331 1.5e-39 130.8 In-house 37-277 (293) alignment 
Range on Protein: 1089-1331
Range on HMM: 37-277/293.0
IDKD-HITESYTYLPEDKHRFPNVPCKPSTAVEV--IVDG-QRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMC
..||  .. . .   ..| |. |.     . |..  . |  .   | ||.||    |. |||||||| .| .||| |...  .. |||. |  |.    |
vgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkC

TDYFPLWfpflsktKNQLKIGRFEIKIKNTEYIlnKKINQRTLEVVDstgKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS------EKPIVVH
 .|.|         ...   |  .......|    ..   |.|..     . ..|....|..  |. .|||.. . | |... |...      ..|||||
eeYWPad.......eepvlyGdikvtlvaeeel..edwvirelkiek...ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvh

CSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
|| |.||. .||  . | ...| . .....  . ..||.| . |||..|  ..
CsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1103-1331 7.5e-39 128.5 In-house 48-271 (288) alignment 
Range on Protein: 1103-1331
Range on HMM: 48-271/288.0
EDKHRFPNVPCKPSTAVEVIV---DGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflsKTK
..| |..|.     ..|..       .   | |..|   .. ...|||||||..| .||| .  ..... |||. .  |.    | .|.|       ...
akknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWP.......dad

NQLKIGRFEIKIKNTEYIlnKKINQRTLEVVdstGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS---E-KPIVVHCSNGIGRSMAFIGTECL
.. . | .........    ... .|.|...    |   ... .|||  |.  |||.|.|.|..|...|| .   . .||.||||.|.||.  ||  ..|
kpknyGsvtvtlveskel..edfvlrkllle...kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdal

AREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
  .||.. .|.........|..| . ||| .|  ..
idaveeedyiDvagtvaklRkqRallvqtlkqYefi
0041856 (Phosphotyrosine protein) phosphatases II 1104-1333 1.9e-37 124.0 In-house 3-165 (182) alignment 
Range on Protein: 1104-1333
Range on HMM: 3-165/182.0
DKHRFPNVPCKPSTAvevivdgQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGqkrenltdmCTDYFPlwfpflsktknqlk
||.|...... . .            |.||..  . .. ||||||||| .|..||. || .... .||.           .  |.|              
dknrysdilpydhsr.......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp..............

igrfeikiknteyilnkkinqrtlevvdstgKFATRTLMHYQYSEWTGYGVPKsHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREveadp
                               .. .|. ..|.|  | ..|||    ||.|..|.|.....|..|||| |.||. ....   . .      
...............................ellerlgiqylylpwpDhgvpd.ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkkl.....

TIELTEALKHVREHRWNGVQTNSQLYWMTL
 . |.||.|.||..|...|.| .|...  |
gvsleeavklvrsrRpgmvitpnqyfflql
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1103-1332 5.3e-37 122.2 In-house 49-280 (305) alignment 
Range on Protein: 1103-1332
Range on HMM: 49-280/305.0
EDKHRFPNVPCKPSTAVEVIVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLW-FPFLSKTKNQ
..| |. .| |     | .        ||||.. ||  |.||| || || .|| ||| | .|  || | |. .  |  .  |..||.    . |.  ...
agknrykdvgcldnnrvklegpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg

LKI-GRFEIKiKNTEYILNKKIN-QRTLEVVDSTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREV
 ||  .||   .. ..  . | . ..|  |.. .|.  .|   || . .|   ||| .   ...|.|  . |  ||||||| ||||. . .  | .  ..
qkisvkfess.vtlkfrkdakakvtetvlviegpge.karkvthyhwidwpdrgvpaadlailellekarpskgpivvhcsagigrtgsvvmleyildql

EADPTIELTEA-LKHVREHRWNGVQTNSQLYWMT
 |   || |.  |...|| | | .||. |  .. 
lagqiiedtdkilqkireqrnnsiqtdaqylfvh
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1126-1328 3.1e-36 120.1 In-house 73-272 (305) alignment 
Range on Protein: 1126-1328
Range on HMM: 73-272/305.0
QRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEYIlnKKINQR
..  | |... .  . ...|..|||| || .||| ..... |..|||. . .|.  | |  |.|       ..... ..|.|....|... .  .   .|
dsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWp......esktekkefgefsvelksekta..sdyieR

TLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS-----EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWN
 |..    ..  .||...||  .|   |||.. . | .|.. |.|.     ..|..||||.|.||. .||  .     .... .... | ||..|..| .
klkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmk

GVQTNSQL
 |||  | 
mvqtldqY
subfamily_PTPN13_pd Subfamily PTPN13 1102-1329 8.1e-36 118.7 In-house 37-259 (273) alignment 
Range on Protein: 1102-1329
Range on HMM: 37-259/273.0
PEDKHRFPNVPCKPSTAVEVIVDGQrvPIHANWIPTP--GHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpfLSKTK
 .|| |. ||     | |..  .|    | |..|  |   . ...||.|||| .|..||| |. . ..| |.|  ...|.    |  |.|      || |
nkdknryrnvlPydetrvklgdegg..yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywP.....esknk

NQLKIGRFEIkiKNTEYILNKKINQRTLEVVDSTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIV---KKSEKPIVVHCSNGIGRSMAFIGTECLA
.    .|.|.  .. ..   .  ..|.|.| ||  . ..| ..| .. .|  .|||.| |||  ..  |   .... ||||||| ||||| ..|  . . 
klkvsnrlev..ellkvqkldgfvvralavkdsesg.esrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvl

REVEADPTIELTEALKHVREHRWNGVQTNSQLY
  .| |  ....| ....|| |   |||. |  
glierdkefdvkeivrklreqrqgvvqtkdqyi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1092-1342 1e-35 118.4 In-house 38-285 (319) alignment 
Range on Protein: 1092-1342
Range on HMM: 38-285/319.0
DHITESYTYLPEDKHRFPNVPCKPSTAVEV-IVDGQR--VPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYF
|..... .   ..| |..|.     | | .  .||.     | |..| .  . ..|||||.|| || |||| |. ....  .||  .  |.|   .  |.
dtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkyw

PlwfpflskTKNQLKIGRFEIKIKNTEYILNkkINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE-----KPIVVHCSNGI
|        ..|  . ||. ..... |   .  .  | |..   ...  ||...|.|| ||.  .||..   | ||.. ..||      .|||||||.|.
p........eenfeeyGrlivtleeeeeled..yiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGv

GRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQlYWMTLGTMYRLIKE
||  .||  .     |. . .... .  ...|  |   ||...| | .   ..   .. 
GRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeq.Ykfiyealleavea
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1102-1331 1.6e-35 117.6 In-house 41-269 (307) alignment 
Range on Protein: 1102-1331
Range on HMM: 41-269/307.0
PEDKHRFPNVPCKPSTAVEVIVDGQRV-PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFP---FLSK
  || |. .|.|.  . . | .||     ||||.. .  .|..||..|||| ||  .|| | .| .|| ..|. .  |     | .|.||        ..
ntdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfge

TKNQLKIGRFEIKIKNTEyilNKKINQRTLEVVDSTGkfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLA-
. | . .  . .|    .   .. ||  ||.|. . .   .||. |.|...|   |||.      .|.| |.  . |.||||| |.||| . ..   .  
apntisvanlgakklapd...edlinvttlkvdwaqk...srtiqhlqwenwpdrgvpqinltainlleavrydtnpvvvhcsaGvGrsGtivaislvqd

REVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
. ..     .. . .. .|..|   .||. |  ..
kmiaGinckdmkklveelrsqrhyaiqteaqylyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1102-1331 2.6e-35 116.9 In-house 41-268 (281) alignment 
Range on Protein: 1102-1331
Range on HMM: 41-268/281.0
PEDKHRFPNVPCKPSTAVEVIVDGQ---RVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFpflskt
   |.|. |.     | |.|  . .      | ||..|.   ....||||||. .....|| |.....|. |||  .. |.    |  |.|         
nvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddn......

kNQLKIGRFEIKIKNTEyiLNKKINQRTLEVVDSTGkfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIV-----KKSEKPIVVHCSNGIGRSMAFIGTE
 ..||.| . .| ...|   ...  .|....  ..|   ||.. . .|  |   |||.. .||..  . |     ||.. |.|.||| |.||. ..|. .
.selkygdvtvkstaee..ekatyierkfkleresg..etreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyialD

CLAREVEAD-PTIELTEALKHVREHRWNGVQTNSQLYWM
 |...|||. ....... ....|..|   |||  |  ..
rlvkaveaeleeldvkavvaelrkernlmvqtvvqyefv
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1129-1330 3.2e-35 116.7 In-house 76-271 (318) alignment 
Range on Protein: 1129-1330
Range on HMM: 76-271/318.0
PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflskTKNQLKIGRFEIKI----KNTEYILnkkinq
 | ||.|.   . . .||.|.||..|.|||| |. . .   |||. |..|.  . .  |.|         |.  ..|.  ...    . ..|.|      
yinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWP........skgsrsygklvvelkeevelsdyvl......

RTLEVVDsTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE-----KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRW
|...|   |.. ..|.   |.| .|.  |||.| |.| ||.  |.| .     .||||||| |.||   ||  . | . ..|. .... .  |..||.| 
refkvtr.teeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrn

NGVQTNSQLYW
  |||..|  .
lmvqtedqyef
0043147 (Phosphotyrosine protein) phosphatases II 1128-1331 1e-34 115.1 In-house 6-153 (172) alignment 
Range on Protein: 1128-1331
Range on HMM: 6-153/172.0
VPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKrenltdmctdyfplwfpflsktknqlkigrfeikiknteyilnkkinqrtl
  |.|...... .|.||||||||| ||..||| || .... |||.  .                                                    
dyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...................................................

evvDSTGKFATRTLMHYQYSEWTGYGVPkSHAELFDLMEIVKK-----SEKPIVVHCSNGIGRSMAFIGTECLAreveadPTIELTEALKHVREHRWNGV
     .... .|. ..|.|  |  .||| . . | ...|....     ...|..|||| |.||. ...    .         . | ||...|||.|...|
...lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgav

QTNSQLYWM
|. ||... 
qnpsqyrfl
subfamily_PTPN3_pd Subfamily PTPN3 1130-1330 3.2e-34 113.1 In-house 68-266 (280) alignment 
Range on Protein: 1130-1330
Range on HMM: 68-266/280.0
IHANW----IPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflsKTKNQLKIGRFEIKIKNTeyILNKKINQR
| ||.    ||. |   |.|||||||..|..||| |. . ... |||. .  |.    |  |.|       .|...|. |.|..|....    .|..  |
inanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWP.......etedeleygefsvkceke..detksyvlr

TLEVVDSTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNG
 | . |.. |   |.... || .|.  |||...|......| |.|     |.|.||||| ||||.  .|  |     .||   .   . ....|. | . 
elvlkdketk.eerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqraml

VQTNSQLYW
|||.||  .
vqtasqykf
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1102-1330 3.4e-34 113.5 In-house 56-281 (298) alignment 
Range on Protein: 1102-1330
Range on HMM: 56-281/298.0
PEDKHRFPNVPCKPSTAVEVIV---DGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflskT
 ..| |....    |. | .     | .   | | .. .  . . |||||.|||.| |||| |....|.. |||. . .|  .  .. |.|        .
nkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywP........d

KNQLKIGRFEIKIKNTEYilNKKINQRTLEVVDSTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS-----EKPIVVHCSNGIGRSMAFIGTE
... . |.........|     .. .|.|.| ... .  .|.. . ....|.  |||. .  ..||.. |..|     .||..|.||.|.||| .||  .
egketygeitvsllskee..fadlivrklkvskkkee.kerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaid

CLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
 .   |... .... ...| .|..| . |||..|  .
svlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvf
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1124-1329 8.7e-34 111.8 In-house 54-258 (274) alignment 
Range on Protein: 1124-1329
Range on HMM: 54-258/274.0
DGQRVPIHANWIPTPGH-PHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEYILNKKI
| .   | ||.|  ...  . ..||||||.|| .||| |. | .|. |||  . .|.  . |. |||       ... ...    ...||... . ... 
dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP......daedyeiserygdveikvekiverndy

NQRTLEVVDSTGkfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE-------KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVR
. |.| .  ..    .|...|| |..|    .|..  .|.||.. |..|.        |.||||| ||||  .||...   |..... .... .   ..|
svrklvlkyler...ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlr

EHRWNGVQTNSQLY
 .|   |||..|  
ldrGGmvqtseqye
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1094-1345 1.4e-33 111.1 In-house 36-278 (288) alignment 
Range on Protein: 1094-1345
Range on HMM: 36-278/288.0
ITESYTYLPeDKHRFPNVPCKPSTAVEVIvDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfp
| .|.   |  . |. |.|.   | | .  |     |.|| ...  ...|.| .| ||  | | .| ||.. |||.|||. .  |   .   .|||    
iidsfianp.trdryenlprcditrvkls.ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP....

flSKTKNQLKIGRFEIKIKNTEYILNKKINQRTLEVVDSTGKFAtrTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTE
  ||  .. .|||.   .|.    ..| ..  .| .   . .     . .  . ||   |||...   . |.|..|. .||||||.|.|.||....| . 
..sklGekarigrlctvvkkkradidklvkvsllriskegeekv..ivkilhlleWdddgvPenylsplrllevlkslqkPivvhssaGvGrtgtlilil

CLAREVEADPTIELTEALKHVREHRWNGVQTNSQ-LYWMTLGTMYRLIKEYGF
  .. .  |  . . . |.. ||.| . .||. | ||   .   . |.| |  
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1101-1333 1.5e-33 110.8 In-house 54-283 (305) alignment 
Range on Protein: 1101-1333
Range on HMM: 54-283/305.0
LPEDKHRFPNVPCKPSTAVEVIVDGQRVPIHANWIPTPGHPH-RFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpfLSKTK
. . | |. .|||.  .|| .        ||||..  |  |. |||..|||| .| ..|| |..|  ||.|||. .  |     |..|.|.        |
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpa....aqgek

NQLKIGRFEIKIKNTEYILN-KKINQRTLEVVDSTGKfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTEC-LAR
 .|| |    ..  .  .    .|.  .|..  | ..  . .. | |..||   |||  .   ..|.  .. |. ||||||| ||||. . .  |  | .
lelksgivvenvsgskpmerdaeiqitllnltysgdq..kmsvrhlqwtewpdrgvppckltslellsairgskvpivvhcsagigrtgtivaieyilek

EVEADPTIELTEALKHVREHRWNGVQTNSQLYWMTL
  |  |   . | .| .|..|   .|.. |  ..  
iaenkpcppmpelvkalrdqrafsiqndvqylfihr
subfamily_PTPN12_pd Subfamily PTPN12 1130-1329 2.3e-33 110.3 In-house 71-267 (290) alignment 
Range on Protein: 1130-1329
Range on HMM: 71-267/290.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEYiLNKKINQRTLEV
| ||.|  .  ....||.||||..| .||| |.....|| .||  .. |.    |  |.|      ......|..| ||.. .. .  ... .  |||.|
inanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp......eegeeelefgefevtleeeka.vdddflirtLkv

VDStgkFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVK----KSEKPIVVHCSNGIGRSMAFIGTECLAREVEA---DPTIELTEALKHVREHRWNGV
  .    ..|..  ..| .|   |||.|. .|..|.| |.    ....|.||||| |.||  . |  .   . ..|   ...... . . ..|..|   |
eaq...kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalv

QTNSQLY
||. |  
qtkeqye
0051429 (Phosphotyrosine protein) phosphatases II 1130-1340 2.4e-33 111.3 In-house 7-226 (272) alignment 
Range on Protein: 1130-1340
Range on HMM: 7-226/272.0
IHANWIPTPGH---PHRFIATQGPLTNTCEDFWMMlMQYDVEHIVMFGQKRENLTDMCTDYFP----LWFPFLSKTKNQLKIGRFEIKIKNTEYILNkkI
|.|......|.   |.|.....|||..|..||| .  .... .||.. .  |   . |  | |    |..|.|. .  .  .|.. ...  .|. |.  .
iNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld..y

NQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHaeLFDLMEIVKKsEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIE--------LTEALKHV
  |.|...   .  ..|..||..|  |  .|||..   | .|.|.. . ..|..|||| |..|.  ..    |.. |...  ..        | ||....
ilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveel

REHRWNGVQTNSQLYWMTLGTMYRLI
|..| . |||  |...     .  | 
raqrpgavqteeqylflyeallellr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1085-1329 1.2e-32 108.1 In-house 30-268 (287) alignment 
Range on Protein: 1085-1329
Range on HMM: 30-268/287.0
NASTIDKDHITESYTYLPEDKHRFPNVPCKPSTAVeVIVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMC
.  | ..|..| . .   .|| |. ..  .    | .. . .   | | .| .  . ..||....|..||  .|| .. .  |. |||  |..|| ...|
eqvtqredevthniasqnkdknRltqilvpdnyrv.llkgehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevc

TDYFPlwfpflsKTKNqLKIGRFEIKIKNTEyiLNKKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYG-VPKSHAELFDLMEIVKKS----EKPIVVHC
 .|.|       ..|. . .| ..|.. | |   |..  .|.|||  .. . ...... ||. .|   | |..  . |. . | .|.     . .|||||
yqyWp.......eeks.vvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhC

SNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLY
|...|||  |.  .   .... . .|.. . ||. |  . . ||| .|  
sdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqyk
subfamily_PTPN9_pd Subfamily PTPN9 1104-1330 2.2e-32 107.3 In-house 44-281 (297) alignment 
Range on Protein: 1104-1330
Range on HMM: 44-281/297.0
DKHRFPNVPCKPSTAVEVI-VDGQRV--PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpflsKTKN
 | |. .| |  .| | .  ||..     |.||..    ... |||||||| .|..|||.|. . .|  |||  .  |.    |. |.||      ....
eknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpl......eees

QLKIGrfEIKIKNTEYILNKKINQRTLEVVDSTgKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK-----------------SEKPIVVHCSNGI
. . |  .....| |   ... ..|.||. ... .  .|...|.|.  |  ||||.| |.|.|..| |..                 |. ||||||| ||
saefg..dlsvsnveveeeedykvrvleiknvk.teesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGi

GRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
||. .||  .    ..|   |....|..|..|. |   .||. | ..
GrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyef
subfamily_PTPN1_pd Subfamily PTPN1 1125-1331 2.5e-32 106.7 In-house 54-263 (290) alignment 
Range on Protein: 1125-1331
Range on HMM: 54-263/290.0
GQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFPflsktKNQLKIGRFEIKIKNTEYILNKKINQ
..   | |. .  .   ...| |||||.||.. || |. . .   .||. .  |. .  |..|.|         ...|..   ..|.|  .   ...   
adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee.....ekellledtklkvkliseerksyytv

RTLEVVDSTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS------EKPIVVHCSNGIGRSMAFIGTECLAREVEADPT---IELTEALKHVR
|.||. . . .  ||...|. |  |. .|||.| | .....  |..|        | |.||| ||||| .|.  ...  ..|.      ... . | ..|
rllelenlktq.etreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelr

EHRWNGVQTNSQLYWM
..|   .||  || . 
kyrlGliqtadqlrfs
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1107-1331 4.6e-32 106.1 In-house 25-256 (270) alignment 
Range on Protein: 1107-1331
Range on HMM: 25-256/270.0
RFPNVPCKPSTAVEV---IVDGQRVPIHANWIP-TPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpflsKTKNQL
|. ..  .| | | .     | .   | ||...   |.....||..||| .| ..|| |...  |. |||  .  |. .. |  |.|       ..|...
RyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa......epkekv

KIGRFEIKIKNTEYILNKKINQRTLEVVdSTGKfaTRTLMHYQYSEWTGYGVPKSHA------ELFDLMEIVKKS----E--KPIVVHCSNGIGRSMAFI
|.   .||. ...   ..   .. |..  ..|.  .| |.|..| .|   |||...       .|  ... |..|    .  .|..||||.|.||.  .|
kledgkikvlalseekeegyiltrlrle.ekge..errlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

GTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
 ..   | .| .  ..... ....|..| . ||.  |  ..
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyefl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1104-1348 6.5e-32 105.3 In-house 58-287 (290) alignment 
Range on Protein: 1104-1348
Range on HMM: 58-287/290.0
DKHRFPNVPCKPSTAVeVIVDG-QRVPIHANWIPtpGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQL
 | |. .|.|   | | .. || .   .|||..   |    || |||.|..|  |.| |..| .|  |||. .  |.    | .|.|       |  . |
kknrykdvvcndktrv.ilkdGydGdyvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyyp......ekeGevl

KIGRFEIKIKNTEyILNKKINQRTLEVVDST-GKfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREVEA
 .| . .   . .   ...| ..|| | |   ||     | |..   |    |..|   |. .. |..|   |.||||| ||||. .|.  |  .. .  
tfGeitvlcseed.dkdaniikktlsvrdkdsGk..ehklkhlkikswpdksvalstlallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilld

DPTIELTEALKHVREHRWNGVQTNSQlYWMtLgtmYRLIKEYGFDMK
   ..| .  . .|. | | || . | | . |    ... ..| |.|
Gkeldlldlvralrnsrlnsvqvdiq.yla.l...veilldlGkdfk
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1127-1329 1.5e-31 104.4 In-house 76-273 (290) alignment 
Range on Protein: 1127-1329
Range on HMM: 76-273/290.0
RVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflsKTKNQLkIGRFEIKIKNtEYILNkKINQRT
   |.| .|    . ...||||||..||  ||| ...| .|  |||  .  |. .. |  |.|       .....  .| |.||. | | .|| .. .|.
neyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWp.......dsdtka.ygefsiklln.eetln.eyierk

LEVVDSTGKFATRTLMHYQYSEWTGYG-VPKSHAELFDLMEIVK----KSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNG
||| ... . |......|| . |   | |.. .. |  . |..|    . ...||||||...|||  |. ..     .. .  |.. . ||. |  . . 
levknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgs

VQTNSQLY
|||. |. 
vqtvqqyq
subfamily_PTPRK_pd Subfamily PTPRK 1123-1329 4.3e-31 102.9 In-house 65-267 (314) alignment 
Range on Protein: 1123-1329
Range on HMM: 65-267/314.0
VDGQ--RVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNqlkIGRFEIKIKNTEyiLNK
.||.     | |..| .  .|. ||.||||| .| .||| .. ...   |||  .  |.    |. |.|       .|.     | ..... .||  |..
idgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP......edtev...ygdikvelvete..lla

KINQRTLEVVD-STGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVR
.. .|.. |   . |. ..|.. ..|.  |. ..||.|   |..|.  ||||.     .||||||.| ||. .||  . .   .| . .... .| | .|
elvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlr

EHRWNGVQTNSQLY
... | |.|. |  
srkvnmveteeqyk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1130-1353 4.3e-31 103.1 In-house 49-275 (290) alignment 
Range on Protein: 1130-1353
Range on HMM: 49-275/290.0
IHANWIPTPgHPHRFIATQGPLTNT-------CEDFWMMLMQYDVEHIVMFGQKRENLTD----MCTDYFPlwfpflSKTKNQLKIGRFEIKIknTEYIL
|||| .  | .  |.|.|| |....        |.|| | .|  |...|| ..  |. ..     |. |.|       .  ..||.. ...|   .. . 
iHAnrvtcp.nglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvp......esvgeelkfkgltvkC..kskek

NKKINQRTLEVVdsTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREVE-ADPTIELTEALKHVREH
.. ...|.|.|    ..    |. |.....|.   |....  | .|.. ||.|. |..||| .|| || |.   .     .      ..|...|| .|..
eddvetRelvvk..fddeeeftvtHsllkgWnklnvqedtktllsliqkvkasktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkq

RWNGVQTNSQLYWMTLGTMYRLIKEY-GFDMKMYE-KQ
| . .... .| ..  | . ..|...  |  .  | | 
ralaitsalelafvdagivllaievldqfaeeetekka
0049260 (Phosphotyrosine protein) phosphatases II 1135-1331 7.9e-31 102.2 In-house 2-142 (152) alignment 
Range on Protein: 1135-1331
Range on HMM: 2-142/152.0
IPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFplwfpflsktknqlkigrfeikiknteyilnkkinqrtlevvdstg
|.  ..|..|||||||. ||..||| || .... .|||  .  |.  . |  |.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

kfatrtlmHYQYSEWTGYGVPKSHAELFDLMEIV----KKSEKPIVVHCSNGIGRSMAFIGTECLAreveadPTIELTEALKHVREHRWNGVQTNSQLYW
        .|..  |  .|||...  | .|....    .....|..|||| |.||. ...    .         ..| ||...|||.|...|.. .||..
........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrf

M
 
l
subfamily_PTPN6_pd Subfamily PTPN6 1129-1343 4.8e-30 99.6 In-house 83-296 (306) alignment 
Range on Protein: 1129-1343
Range on HMM: 83-296/306.0
PIHANWIP--TPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflsKTKNQLKIGrfEIKIKNTEYILNKKINQRT
 | || |   ..|. ...||||| |..| .||| |..| . . |||  .. |   ..|. |.|       ..... . |  .|...|..   ... . |.
yinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWP.......deeekeeyG..kisvtnvseksladYilRe

LEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS--------EKPIVVHCSNGIGRSMAFIGTECLAREVE---ADPTIELTEALKHVR
| |   . |  .|....|.. .|   ||||.   . |..| |..         . |||||||.||||  .|| ...| . .|    |  |.. .. | ||
lsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvr

EHRWNGVQTNSQLYWmtlgtMYRLIKEY
|.|   |||..|  .     .|. ||.|
eqrsglvqteqqykf.....vykaikky
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1132-1330 5.4e-30 99.4 In-house 42-233 (250) alignment 
Range on Protein: 1132-1330
Range on HMM: 42-233/250.0
ANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDmCTDYFPlwfpflskTKNQLKIGRFEIKIKNTEYIlnKKINQRTLEVVd
| .. .    . ||||||||..| |||| |....... |||. . .|.    ...|.|        ...  | |   ......|      . .|.| .  
asflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP........vekaekyGdvtvsllskeef..adytkrklkls.

STGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE-----KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNS
.. |   |.. ....  |   |||.     ..|.. |..|.     .|..|.||.|.||| |||  ...   .. . .... . .| .|..| . |....
kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesle

QLYW
|  .
qyvf
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1129-1328 6.9e-30 99.0 In-house 79-268 (315) alignment 
Range on Protein: 1129-1328
Range on HMM: 79-268/315.0
PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWfpflsktknQLKIGRFEIKIKNTEYilNKKINQRTLE
 . ||.|.   ...|.||.|||.... .||| .....|. .|||. .  |.   ..  |.|           ..  |.. .  |. |.  |...  ||| 
yvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.........kviyGkitvtrkseev..nteytvrtls

VVDstgKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQT
||    .   |... ..|. |   ||||.   | .|.  ||.       .||||||.|.||. .||  ...  ..||.  |.. .... ||. | . ||.
vvf...gdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqv

NSQL
  | 
aeqy
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1130-1328 8.3e-30 98.6 In-house 60-255 (283) alignment 
Range on Protein: 1130-1328
Range on HMM: 60-255/283.0
IHANWIP---TPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflskTKNQLKIGRFEIKIKNtEYIlNKKINQRT
| | .||      . ...|..|.|| .|  ||| |. . ..  |||. . .|.|   |. |.|         .   . | | . ... |.  ..   .. 
inavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWP........krGsedyGeftvtlrk.ett.snsfiike

LEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAEL--FDLMEIV--KKSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGV
| .  ..   .|  | |||. .|. ||       |  |...     .. . |||||||.||||. .||.  .   .. ..  ... . .| .||.|   |
lllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmav

QTNSQL
||  | 
qtldqy
subfamily_PTPN23_pd Subfamily PTPN23 1138-1329 8.8e-30 98.5 In-house 80-270 (288) alignment 
Range on Protein: 1138-1329
Range on HMM: 80-270/288.0
PGHPhRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEYilNKKINQRTLEVvDSTGKFA
|| |  |||||.|| .|  |||.|...  .. |||  .| |     .  |.|      ... .  | | ... .|...    ..  .|.|.. .  .. |
pgcP.dfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwP......edkgetvkfgdlsvtlksvre..tethvervlkl.etldada

TRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK--------SEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTI-ELTEALKHVREHRWNGVQTNSQL
.....| |. .|. .|||.|  .|..... |..        |..|.||||| |.||. .|    . .||.|... . .. . ....|| | . ||...||
vksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeql

Y
 
k
subfamily_PTPRG_pd Subfamily PTPRG 1130-1331 2.3e-29 97.1 In-house 79-279 (563) alignment 
Range on Protein: 1130-1331
Range on HMM: 79-279/563.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflsKtKNQLKIGRFEIKIKNTEYILNKkiNQRTLEV
| ||.|    . . ||||||||..|..||| |. .  |. |||  .  |.    |  |.|       |  . ...| ........| .     ..||| .
inAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWP.......k.desetygalqvtlieeevlaly..tvrtlvi

VD-----STGKFATRTLMHYQYSEWTGYGVPKShaELFDLMEIVKKSE------KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHR
 .        .   .. ..|.|..|   |||..  .|..|. ..|.|        |||||||.|.||.  .|  . | ...... .... . |||.| .|
knlklkkkkqcdteklvrqyhytkWPdhgvPeh..slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqR

WNGVQTNSQLYWM
 . |||. | ...
nflvqteEqYifl
subfamily_Ptp69D_pd Subfamily Ptp69D 1130-1344 2.5e-29 97.4 In-house 79-286 (307) alignment 
Range on Protein: 1130-1344
Range on HMM: 79-286/307.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWfpflsktkNQLKIGrfEIKIKNTEYILNKKINQRTLEV
| |..| .  . ..||| |.|. .| .||| |... .|. |||  .  |   . |  |.|          .. . |  .| .|  .    ..  .|.|.|
inasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie........devqyg..dilvklvseekhsdyiiReldv

VDSTG----KFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIV----KKSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNG
           ..| .. |.| .|  . ||..   |..|.| |    |... |||||||.| |||  |.  . |  ...|. .... |  |..|..|   
skkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnll

VQTNSQLYWmtlgtMYRLIKEYG
||   |  .     .|| . .| 
vqsleqYvf.....lyralldys
subfamily_PTPRA_pd Subfamily PTPRA 1130-1343 3e-29 96.9 In-house 89-294 (330) alignment 
Range on Protein: 1130-1343
Range on HMM: 89-294/330.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflskTKNQLKIGRFEIKIKNTEYILNKKINQRTLE-
| | .|    . ..|||.|||...| |||| |. ...   |||. . .|   . |. |.|        ..  .  |   ....... . .  . .  .. 
inasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP........deGlvtyGnirvevedetvlvdytvrkflvqq

VVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQT
. |.| . ..| .  . .  |   |||     ...|.. ||| .     ||||||| |.||. .||  . .   |.|.  ... |..|..|  | . |||
lpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqt

NSQLYWmtlgtMYRLIKEY
. |  .     .|. ..||
deqyef.....iykvlley
0036282 (Phosphotyrosine protein) phosphatases II 1130-1330 3e-29 97.3 In-house 5-161 (174) alignment 
Range on Protein: 1130-1330
Range on HMM: 5-161/174.0
IHANWIPTPGHPHRFIATQGPLTntcedFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpflsktknqlkigrfeikiknteyilnkkinqrtlev
|.|...     . |.||.||||.     || || .......||. . .|.   .| .|.|                                        
inaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.......................................

vdsTGKFATRTLMHYQYSEWTGYGVPKSHAeLFDLMEIVKKS-----EKPIVVHCSNGIGRSMAFIGTECLAREVEaDPTIELTEALKHVREHRWNGVQT
   . .. .|. ..|.|  | ..||| ..  |......|..      ..|..|||| |.||. ....   . |  .  ....  . .. .| .| ..|||
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

NSQLYW
 ||...
psQyrf
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1102-1329 4.7e-29 96.5 In-house 46-278 (325) alignment 
Range on Protein: 1102-1329
Range on HMM: 46-278/325.0
PE--DKHRFPNV-PCKPSTAVEVIV--DGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMfGQKRENLTDMCTDYFPlwfpflS
||  .| ||.|| . . | .| .    |..   | |... .    . |.|.| |||.| .|.| .....    .|.   . ..  | |. |.|       
penkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv.lneldlgkdrcavywp......k

KTKNQLKIGRFEIKIKNTEYIlnKKINQRTLEVVDSTgKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK----------SEKPIVVHCSNGIGRS
.  .  . | .|.|..  | |      .| |.| .   |  ||..  .|.  |   ||.|  | |  ....||.          .  ||.||||.|.||.
emgksktfGglevklrtieei..sdyvhrvldvkqvk.kGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrt

MAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLY
 .||   ... .|  .  ... . .|..|..| . |.|  |  
Gvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1130-1332 8.7e-29 95.8 In-house 92-284 (319) alignment 
Range on Protein: 1130-1332
Range on HMM: 92-284/319.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGqkrenlTDMCTDYFPLwfpflsktKNQLKIGRFEIKIKNTEYILNkkINQRTLEV
| | ..    .. ..||.|||| || .||| |. .|..  ||..        |.|..|.||        | . | .||..|..  |   .     | .|.
inasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywpl........kivikeerfkvkvdsveetae..yvvrdiel

VDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVK------KSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQ
 . . .   | .  . .  |  .|||.. ..|. |.. |.      . ...|||||| |.||. ..|  ..|   .. .  ... . .. .|. | . ||
sedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvq

TNSQLYWMT
   | ... 
dlvqykfiy
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1130-1333 1.1e-28 95.6 In-house 56-249 (284) alignment 
Range on Protein: 1130-1333
Range on HMM: 56-249/284.0
IHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGqkrenlTDMCTDYFPLwfpflsktKNQLKIGRFEIKIKNTEYILNkkINQRTLEV
| | .|    .....||||||| || .||| |. .|..  ||..        |.|..|.||        | . | .||..|..  |   .     | .|.
inasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl........kivikeerfkvkvdsveesee..yvvrdiel

VDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVK------KSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQ
 . . .   |..  . .  |  .|||.. ..|. |.. |.      . ...|||||| |.||. ..|  ..|   .. .  ... . .. .|. | . ||
sedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvq

TNSQLYWMTL
   | ...  
dlvqykfiys
0046846 (Phosphotyrosine protein) phosphatases II 1123-1330 1.7e-28 95.0 In-house 8-164 (176) alignment 
Range on Protein: 1123-1330
Range on HMM: 8-164/176.0
VDGQRVPIHANWIPTPghphRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFPFLSktknqlkigrfeikiknteyilnkki
 |.  . |.||.| ..    |.||||||| .|..||. || .......|.. . .|     |..|.|..  .                            
ldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

nqrtlevvdstgkfatrtlmHYQYSEWTGYGVPKShAELFDLMEIVKKSE---KPIVVHCSNGIGRSMAFIGTEclarEVEADPTIELTEALKHVREHRW
                    .|..  |  .||| . . |..|.|....     .|..|||| ||||. ...        .| .  . . |||..|||.|.
....................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRp

-NGVQTNSQLYW
 . ||| .|...
lgavqtpeQyrf
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1103-1360 1.8e-28 94.1 In-house 44-295 (312) alignment 
Range on Protein: 1103-1360
Range on HMM: 44-295/312.0
EDKHRFPNVPCKPSTAVEVIVDgQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFPFLSKTKNQL
 |  |.||. |       .  | .   ||||..    .| ||..||||| |||  || . .      |...    |. .. |. |      |.     ..
kdlnrypniqcwdrgrftlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrv

KIGR-FEIKIKNTEyilNKKINQRTLEVV-DSTGKfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREVE
      ||.|       . || .| | ||  .||.     | |||.. |  .|.| |    . |.  |||  ||.. ||| |.||. ...  | .   . 
yteycteieiggks...kdkithrvlkvvvkatgq..esklnhyqwaswpdhgmpdscdtalrllsavkkdkkpviahcsagvgrtgtlaliesmiaalr

ADPTIELTEALKHVREHRWNGVQTNSQlYWMTLGTMYRLIKEYGFdMKMYEKQMAMFTDV
     .. ...  .|  |   |..  | | ..| ..  ..   |. .|  |.... | ..
hprkqnvkdsfvllrkdrarsvrvfpq.yvyalrcvleflyskgl.ykrneqewtkfket
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1103-1342 5.9e-28 92.6 In-house 36-273 (285) alignment 
Range on Protein: 1103-1342
Range on HMM: 36-273/285.0
EDKHRFPNVPCKPSTAVeVIVDGQRVPIHANWIPTPGHPH-RFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQ
 |  |. .| |   | | |. . .|  |||.|.  ||. .  .|.||||| .|  ||| |. |  . ...|.    |   . |. |.|       |  . 
pdlnryadvrcieetrv.vlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp......eklgev

LKIGRFEIKIKNT--EYILNKKINqrTLEVVDSTGKFAT-RTLMHYQYSEWTGYGVPKSHAELFDLMEIVKK---SEKPIVVHCSNGIGRSMAFIGTECL
.|.|..|| . .   | |    .|  .| |...    .    . | |   |     |.    . .| . |||    ||||.|||| |.||. .|.| .  
vkfgkyeitlteckeeaiagtiln..altvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidya

AREVEADPTIELTEALKHVREHRWNGVQTNSQLYWMTLGTMYRLIKE
.  .  .| ||. . .. .|  |.. ||.  |. .. .  |  .| |
tirimenpniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1072-1331 9.1e-28 92.2 In-house 23-276 (297) alignment 
Range on Protein: 1072-1331
Range on HMM: 23-276/297.0
RTAKFCNTTIESVNASTIDKDHITESYTYLpeDKHRFPNVPCKPSTAVEVIVDGQR---VPIHANWIPtpGHPHRFIATQGPLTNTCEDFWMMLMQYDVE
| ... .  .  . ...| ..  .|    .  .| |. |.    |  |.. . ..      . | ...  |  ||.|.|| |  .| .||| |.....| 
rhtdvfseeflclpeaniqpqtvaekkvnf..eksRYkniLPydssRvkLaivnddpdsDyvnasfvk..gnkhrlittqmPmkatvadfWamvldeqvs

HIVMFGQKRENLTdMCTDYfplWFpflSKTK-NqlkIGRFEIKIKNTEYilNKKINQRTLEVVDSTGKfATRTLMHYQYSEWTGYGVPK--SHAELFDLM
 |||  .. |.    |. |   |.    |.  .    |   .... ..    .   .|.|||  .  | |.| .  ||. ||    |..  | . | .|.
tivmlnddnerdk.kcary...Ws...dkgvtt...fGdvsvvllsvse..reGfikrelevtkgkak.arrvvkqyqfveWPdkaverkdsassllkli

EIVKK-----SEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
. |.|     .| |..|||..|.||   ..  .    |.. . .... . .|..|..| . |||. |  ..
sevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfv
WSN Domain of unknown function 40-106 7.2e-27 83.1 Pfam-A 2-68 (69) alignment 
Range on Protein: 40-106
Range on HMM: 2-68/69.0
KPTDYLDHITIIAHIANGITLQAGLMNGTIPINEVVGEMLNLGSANVSDLINYKPDKILELIKKLKE
.....|....|||...|||.|||||.||.|||..|. |.||.||...|.|.....||. | ..||.|
elqtvleklsiiaRvtngIyLqaglingsipiddviaELLnigssslsqllkidvdklkeklnklse
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1129-1329 9.2e-27 88.3 In-house 73-266 (515) alignment 
Range on Protein: 1129-1329
Range on HMM: 73-266/515.0
PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEYILNkkINQRTLE
 . |  ||.    . .||.|||.  . .||| ...|..|  |.|  ...|.    |. |.|       |  . .| | .....  .|   .    .|.|.
yfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP......dkpgdsvkfGsikvelvsleactg..gikrklt

VVDSTGkfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQT
|. .     .||.  ... ||   ||||    |. |.  || ..     |...||| |.||   .|  .    ...   .... . .. .|..|   |||
vlkgdd...srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqt

NSQLY
. |  
qeqya
subfamily_PTPN14_pd Subfamily PTPN14 1138-1328 1.2e-26 88.4 In-house 89-285 (300) alignment 
Range on Protein: 1138-1328
Range on HMM: 89-285/300.0
PGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpfLSKTKNQLKIGRFEIKIKNTEYILNKKINQRTLEVVDSTgkfA
 |. . .|..|||| .|..||| |. . .|. |||  ...|.  . .  |||     |.. |.... |.|..  | .|       .. .|. . |     
ggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPk....leskkktvefgkfkvttkfsedsdsvittglklkhlpsk...e

TRTLMHYQYSEWTGYGVPKSHAELFDLMEIVK-------------KSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQT
 ||..| || .|.  |||.   . .. .| |.             .|. |..||||.|.||.   | .. |   .| . .|.. ..|...|| |   |||
ertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqt

NSQL
 .| 
laqY
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1105-1330 4.9e-26 86.3 In-house 47-268 (315) alignment 
Range on Protein: 1105-1330
Range on HMM: 47-268/315.0
KHRFPNVPCKPSTAVE--VIVD-GQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQ
| |. |.    |. |   || |  ..  | |  |..  . . .||.||||  . .||| |..|..|  |||  .|.|.    |  |.|       .  . 
knryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP......drkads

LKIGRFEIKIKNTEYIlnKKINQRTLeVVDSTGkfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCSNGIGRSMAFIGTECLAR
 . | ..... ..|        .| | |.  .   ..||.  .|. ||   ||.|  . |. |.  || .    | ...|||| |.||.  .|  .    
vefGsikvellslead..tdgvarkl.vtrkse..esrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevva

EVEADPTIELTEALKHVREHRWNGVQTNSQLYW
...   .... . .| .|..|   |||. .  .
qikrtrsvdvfnfvknlrakrpylvqteeeyaf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1154-1330 2e-24 81.1 In-house 40-212 (255) alignment 
Range on Protein: 1154-1330
Range on HMM: 40-212/255.0
TCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpflsKTKNQLKIGrfEIKIKNTEyiLNKKINQRTLEVVDSTG-KFATRTLMHYQYSEWTGY
| . |. ...| . | .||..   |.  . |  ||||      .  ..||.   ....  |.     ..  ||||..   | |  |.|. ||.|  |   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl......ekdeklkla..dvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPKSHAELFDLMEIVKKSeKPIVVHCSNGIGRSMAFIGTECLAR----EVEADPTIEL--TEALKHVREHRWNGVQTNSQLYW
  |.   |.  .. .|..| |..|||||.||||| ||. .| . .     ..  .|.||   . |...|..|   ..|  || .
naPelareilnilkvvrds.ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1102-1328 4.2e-24 79.7 In-house 37-258 (281) alignment 
Range on Protein: 1102-1328
Range on HMM: 37-258/281.0
PEDKHRFPNVPCKPSTAVEVIV----DGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSK
 . | |. |.||   . |.. |          ||||.| .|   . .| ||||  .|  ||| |. | .   |||. |  |   . |..|||       .
nnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp......rn

TKNQLKIGRFEIKIKNTeyILNKKINQRTLEVVDsTGkfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAR
..  |.. .. .. ...   .|| .    |..    |   || . |. . ||  . ||.|   .. ..  ..    | |.||| |.||| ...  |   .
ahcclqfdklsvsyeds..tvnkslvttrlnlsy.eg..etrlithwlwkewpdwqvpessevmlkilrkirarstppvihcsagvgrsgtlmaveialq

EVEADPTI-ELTEALKHVRE-HRWNGVQTNSQL
 . .  |. .. . . |.|   |   |||  | 
sihshftlpdikqivshlrvtgraasvqtlqqy
0049772 (Phosphotyrosine protein) phosphatases II 1081-1331 1.5e-23 79.4 In-house 25-272 (314) alignment 
Range on Protein: 1081-1331
Range on HMM: 25-272/314.0
IESVNASTIDKDHITESYTYLPEDKHRFPNVPCKPsTAVEVivDGQRV----PIHANWIPTPghpHRFIATQGPLTNTCEDF----------WMML--MQ
. ... |.. . .|. .. .|  || |...... . . | .  .|. |     |.|... ..    .|||||||| .|..||          | |    .
lnrrslsvlpeltilvadlflnrdknryldilpad.nrvil..pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgd

YDVEHIVM---------------------FGQKRENLtdmctdyfplwfpflsktknqlkigrfeiKIKNTEYILNKKinqrtlEVVDSTgKFATRTLMH
..|  |||                     . .  .|                               . . ... . |      |....  .. .|. ..
lnvrdivmsrdevladelsrLdaAlgKtpllildgng.............................neptaadlellk......eelydp.elferlgik

YQYSEWTGYGVPkSHAELFDLMEIVKK--SEKPIVVHCSNGIGRSMAFIGTECLAREVeadpTIELTEALKHVREHRW-----NGVQTNSQLYWM
| .  ......| . . . ...|....   ..|..|||. |.||.  |. . .| .       . | |||..||. |      . ...  |....
ylripvpDgsap.lledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefi
0051082 (Phosphotyrosine protein) phosphatases II 1129-1330 2.4e-23 77.8 In-house 5-144 (151) alignment 
Range on Protein: 1129-1330
Range on HMM: 5-144/151.0
PIHANWIPTPghphrFIATQGPLTntceDFWMMLMQYDVEHIVMFGQKRENLtdMCTDYFPLWFpflsktknqlkigrfeikiknteyilnkkinqrtle
.|.....        .....|||     ||. .| .... .||.. .. |.   .|..|.| .                                     
yinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg....................................

vvdstgkfatRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS-EKPIVVHCSNGIGRSMAFIGTECLAREveadptIELTEALKHVREHRWNGVQTNSQ
          ....|...  |. .|.| | ... ...|.. .  ..|..|||| |.||. ....  ....       . | |||...|..|.. ||.| |
..........ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

LYW
 . 
flf
subfamily_hpo-7_pd Subfamily hpo-7 1151-1330 5.7e-23 76.1 In-house 43-218 (263) alignment 
Range on Protein: 1151-1330
Range on HMM: 43-218/263.0
LTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLwfpflsKTKNQLKIGrfEIKIKNTEYILnkKINQRTLEVVDSTG-KFATRTLMHYQYSEW
| .| . |. .. |   | .||..   |.  . |  ||||      .  ...|.   ....  |. .   ..  .|||..   | |  |.|. ||.|  |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl......ekdekqkla..nvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgW

TGYGVPKSHAELFDLMEIVKKSeKPIVVHCSNGIGRSMAFIGTECLAR----EVEADPTIEL--TEALKHVREHRWNGVQTNSQLYW
     |.   | . .......| |..|||||.||||| ||  .| . .     ..  .|.||   . |...|..|   ..|  || .
iekndpelareilnilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1127-1329 2.8e-22 73.8 In-house 70-283 (301) alignment 
Range on Protein: 1127-1329
Range on HMM: 70-283/301.0
RVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPL-------WFPFLSKTKNQLKIGRFEIKIKNTeYILN
|  | |..|    . ..|||.|||. .|  ||| ...|. . .|||  ...|.  . |. |.|          ||  . .|.  .  | |.  |   | .
reyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnv.kiqd

KKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGV-PKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHV
   |...   .. . ........ .|  .|   || .  .  |  . .....       |.|||||....||  ..  .     . |.  ... .  | |
gsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkav

REHRWNGVQTNSQLY
|  .   |.|  |  
rrskpgaVtTLeqyt
subfamily_CG7180_pd Subfamily CG7180 1140-1327 3.3e-22 73.5 In-house 83-278 (296) alignment 
Range on Protein: 1140-1327
Range on HMM: 83-278/296.0
HPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTdMCTDYFPLWFpflsktknQLKIGRFEIKIKNTE-----YILNKKINQR--TLEVVDS
... .| |..| ..| ..|| .. . ... .|.  .. .    |. .|.|           . . | ....| ...      | . |....  .|   . 
kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks........keqygeifveiveekqyanlkirtfkltkkivalteqek

TGKFATRTLMHYQYSEWTG-YGVPKSHAELFDLMEIVK----KS-----EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGV
  |  ||.....|. ||     || | . | .|.. |.    |      |.|.||..|.| .|| .... .     || .  ... ||.| .|..| . |
qvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLv

QTNSQ
..  .
envee
0044763 (Phosphotyrosine protein) phosphatases II 1127-1332 3.6e-22 74.3 In-house 18-164 (178) alignment 
Range on Protein: 1127-1332
Range on HMM: 18-164/178.0
RVPIHANWIPtpghPHRFIATQGPltntcEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFPflsktknqlkigrfeikiknteyilnkkinqrt
  .|.|..|     |. ......|     .|.. .| .... |||.. .  |.    |  |.|  .                                  
sdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................................

levvdstgkfatrtlMHYQYSEWTGYGVPKSHAELFDLMEIVK----KSEKPIVVHCSNGIGRSMAFIGTECLAREveadpTIELTEALKHVREHRWnGV
               ..|..  . ..||| . . .....|...    ....|..|||| |.||| ...    . .       . | ||...|||.|. .|
...............iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaielvrerRp.iv

QTNSQLYWMT
.. .||... 
pnpgqlrqLy
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1138-1330 1.5e-21 71.7 In-house 41-230 (237) alignment 
Range on Protein: 1138-1330
Range on HMM: 41-230/237.0
PGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflsKTKNQLKIGRFEIKIKNTEYILNKKInqRTLEVVDSTGKFA
 | |...||.|||| ..|.||| |. |     |||.    |.    | .|.|       .|..    | . . .|  | . .  .  |.| ..  . .  
dgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.......stdqpaaygvltvslkkkeefsdytv..rslllskrltlke

TRTLMHYQYSEWTGYGVPKSHAELFDL-MEIVKKSEK-----PIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
 | .  ||.. |   |||.  | |. .  .|...|..     | ..||| |.||.  |.  ... |. .    ... . .. . | |   .||. |  .
vrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1139-1333 3.8e-20 67.1 In-house 48-234 (239) alignment 
Range on Protein: 1139-1333
Range on HMM: 48-234/239.0
GHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfPFLSKTKNqlkigrFEIKIKNTEYILNKKInqRTLeVVDSTGKFAT
| |. .||||| .. .. ||| |. |     |||.    |     | .|.|      ||  |      . . ...|| . .  |  ||. |.   |.   
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycn......lrvtlrktevfadyii..rtf.vmsqvgqtee

RTLMHYQYSEWTGYGVPKSHAELFDLME-IVKKS---EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWMTL
| . .|... |   |||.  . .. |   | | |    .| |.||| |.||. ||.  ... |. . . |... . .| .|| |   |||. |  .. |
ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1139-1333 3.9e-20 67.0 In-house 49-235 (239) alignment 
Range on Protein: 1139-1333
Range on HMM: 49-235/239.0
GHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfPFLSKTKNqlkigrFEIKIKNTEYILNKKInqRTLeVVDSTGKFAT
| |. .||||| .. .. ||| |. |     |||.    |     | .|.|      ||  |      . . ...|| . .  |  ||. |.   |.   
gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstskycn......lrvtlrktevfadyii..rtf.vmsqvgqtee

RTLMHYQYSEWTGYGVPKSHAELFDLME-IVKKS---EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWMTL
| . .|... |   |||.  . .. |   | | |    .| |.||| |.||. ||.  ... |. . . |... . .| .|| |   |||. |  .. |
ryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1094-1330 1.3e-19 65.1 In-house 33-268 (287) alignment 
Range on Protein: 1094-1330
Range on HMM: 33-268/287.0
ITESYTylpEDKHRFPNVPCKPSTAVEVIVDGQRV--PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlw
 .| ..     | |. .|     | | .  .|.     | ||....  . ..|||.|||.. |  ||| ....  .  ...  .. |.    |  |.|  
aeelaa...vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP..

fpflsKTKNQLKIGRFEIKIKNTEyILNKKINQRTLEVVDSTGKFAtRTLMHYQYSEWTGYGVPKSHAEL----FDL---MEIVKKSE--KPIVVHCSNG
     . .  ...| . . . . . |.. .   |.| ..|  .. | | .  ... .|   ... .   |    .|    .|. ....   |.|||.. |
.....erevPmrvGGysvvlldyd.ikePeygvralrlidletrea.rvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvG

IGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
||||  .. |  | .  |    .. . .. ..||.|   ||.  ||  
iGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrl
subfamily_egg_pd Subfamily egg 1087-1328 2.2e-19 64.3 In-house 25-259 (307) alignment 
Range on Protein: 1087-1328
Range on HMM: 25-259/307.0
STIDKDHITESYTYLPEDKHRFPNVPCKPSTAVEVI-VDGQRV--PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENltDM
 ..|.  .|....    .| | . |.|| |. |..    || .   |||| .        || .| || || .||| |..| .|..|||.  ..|.  . 
esvdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CTDYFPLwfpfLSKTKNQLKIGRFEIKIKNTEYILNKKINQRTLEVVDSTgkFATRTLMHYQYsEWTGYGvpKSHAElFDLMEIVKKSEKPIVVHCSNGI
|  |.|       .   ..  | ..|.  . .   .   .   | .| .      | | |.|. ..   .  . .   . ..  ...  ||.||.. .|.
ceyywpk....aesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg.dvnnss..dvysp.lrvlrklrnlskpvvvqdilGv

GRSMAFIGTECLAREVEADPTIE--LTEALKHVREHRWNGVQTNSQL
 .. ...  |    ..   |.    . .| . .| .|   |..  . 
skaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvlly
subfamily_PTPRN_pd Subfamily PTPRN 1143-1329 2.2e-19 64.3 In-house 101-282 (297) alignment 
Range on Protein: 1143-1329
Range on HMM: 101-282/297.0
RFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQlkIGRFEIKIKnTEYILNKKINQRTLEVVDsTGKFATRTLM
 .|||||||..|  ||| |. .  |  ||.. . .|. .  |. |.|       . ..    . .|...  .|.|  .    |.. . .   .  |||. 
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywp......deGsev..yhiyevhlv.sehiwcddylvrsfylkn.lqtsetrtvt

HYQYSEWTGYGVPKSHAELFDLMEIVKKSE----KPIVVHCSNGIGRSMAFIGTECL-AREVEADPTIELTEALKHVREHRWNGVQTNSQLY
 . .  |.  ||| |   |...   | ||      |||||||.| ||. ..|  . . .| .     |... .|.|.|. | . |.|..|. 
qfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfe
0048076 (Phosphotyrosine protein) phosphatases II 1220-1332 7.6e-19 63.3 In-house 26-136 (145) alignment 
Range on Protein: 1220-1332
Range on HMM: 26-136/145.0
KKINQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS---EKPIVVHCSNGIGRSMAFIGTECLAReveadPTIELTEALKHVRE
|. . .|.  . |. .. .|. ..|.|  | ..||| ... | ...|....    ..|..|||| |.||. ....  .. .       . | |||..||.
kdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrs

HRWNGVQTNSQLYWMT
.|...|.. .||... 
qrpgavpnpgqlrfly
PTPc_DSPc_SM00012 1241-1328 8.1e-19 63.1 In-house 2-96 (105) alignment 
Range on Protein: 1241-1328
Range on HMM: 2-96/105.0
LMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEK------PIVVHCSNGIGRSMAFIGTECLAREVEAD-PTIELTEALKHVREHRWNGVQTNSQL
..||.|..|.  |||..  ....|.. |||...      |.|||||.|.||.  |.  ..| . .|.   .... . .|..|..| . |||. | 
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqy
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1104-1331 1.4e-17 58.3 In-house 54-282 (310) alignment 
Range on Protein: 1104-1331
Range on HMM: 54-282/310.0
DKHRFPNVPCKPSTAVEVIVDGQRV--PIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWfpFLSKTKNQ
 | |. .| |. .. | . .|  |    ||||.. |      || .||||  |  ||| |..|   | |... .  |.    |  |.|     ...|   
hknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpsl..gvtetygc

LKIGRFEIKIKNTEyILNKKI--NQRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREV
...  .    .. | | |  .      . | .   ..    .   .. .|   |||  .        . .    | ||||| |..|  . .  .     .
irvtnlsesseefe.icnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkl

EADPTIELTEALKHVREHRWNGVQTNSQLYWM
.    ... |   ... .|   .||. |  ..
drglkvdaeevktellksraiciqtelqylii
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1104-1331 1.4e-17 58.2 In-house 47-228 (392) alignment 
Range on Protein: 1104-1331
Range on HMM: 47-228/392.0
DKHRFPNVPCKPSTAV--EVIVDG-QRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLtdmctdyfplwfpflsktkn
 | |. |.    |. |  ||| |  ..  . | .||.    . .||.||| . . .||| |..| .|  |.|  . .|                      
kknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd....................

qlkigrfeikiknteyilnkkinqrtlevvdsTGKfATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS----EKPIVVHCSNGIGRSMAFIGTECLA
                                 |.  .||   ....||   .|||  . |. ... ||       .|...||| |.||.   |  ... 
................................kgd.dartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvv

REVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
   .    ... . .  .|..|   |||. |  ..
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1150-1335 1.6e-17 57.9 In-house 99-284 (302) alignment 
Range on Protein: 1150-1335
Range on HMM: 99-284/302.0
PLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEYILN-----KKINQRTLEVVDSTGKF-ATRTLMH
|  .|.| .| .. ||.|  .| . .  |.    |..|.        | ...|| ||. .| .. .  |.     |...  |.|. ..  |    .|.  
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyys......dkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdi

YQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWMTLGT
 ..| |  .| ||     .|..   .   | ..||||.|.||. ...           . . .| . .. ||. |.  ||...|| .. |  
lafsawpdhGapkeaytaldilkfcesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1081-1328 2.1e-17 58.0 In-house 12-248 (267) alignment 
Range on Protein: 1081-1328
Range on HMM: 12-248/267.0
IESVNASTIDKDHITESYTYLPEDKHRFPNV-PCKpSTAVeVIVDGQRVPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMfgqkren
 | ..  . ..  |. |..   ....|. .. | .  | | .. . ..  | | .. .    . ||.||.|| ||  ||. ......|  ||.       
felikkisdtsstisqsiaeknqernrlddnlpyd.dtrv.ilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvivl.......

LTDMCTDYFPLWFPF-LSKTKNQLKIgrfeikikNTEYILNKKINQR---TLEVVDSTGkfATRTLMHYQYSEWTGYGVPKSHA-ELFDLME--IVKKSE
||   ||  .| .|  . ..|.   .          |. |.|. |.    |||.       ... .  | | .|      | .   || ..    ... .
ltkvftdnirlfwPPkmgqakkyqdl........tvehslekeendyqiitlelkfkne..sahnvtlyyykkwnintnnkpylkplfgilaknqlengn

KPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQL
.|.||.||.|.||| .|.  .   . .  . . .. . |...|. |   |.|  . 
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkery
0048179 (Phosphotyrosine protein) phosphatases II 1231-1331 5.5e-17 57.3 In-house 39-137 (144) alignment 
Range on Protein: 1231-1331
Range on HMM: 39-137/144.0
DSTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS---EKPIVVHCSNGIGRSMAFIGTECLAreveaDPTIELTEALKHVREHRWNGVQTNSQ
.    | .|. ..|..  | ..||| . . | ...|....    ..|..|||| |.||. ...    .         . | |||..||..|...|.. .|
eyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpgq

LYWM
|...
lrfL
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1103-1330 8e-17 55.8 In-house 49-270 (439) alignment 
Range on Protein: 1103-1330
Range on HMM: 49-270/439.0
EDKHRFPNVPCKPSTAVEViVDGQR----VPIHANWIPTPGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTdmctdyfplWFPFLSKT
. | |. .|     | | .  .         | ||.|     .. .||||||  .|..||| ....  . .|||. .  |            ..|  ...
qtknrykdvgafdhtrvtl.qeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk.........ywpsdaev

KNQLKIGRFEIKIKNTEYILNkkiNQRTLEVVDSTGKfaTRTLMHYQYSEWTGYGVPKSHAELFDLMEIVK-----KSEKPIVVHCSNGIGRSMAFIGTE
     . | . .|.  .|..      . ..  |.| |   ||.....|  |    ||   . . |..  ..     .   |.||||| |.||. . |  .
cygdiavrvdrnielpnyvir...gfkvfnerdttek..ertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiiald

CLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYW
    .. ..  ...   .| .|..| . ||.  |  .
ialeqlklenkvdikgivkvlrkqrkqmvqalcqyvf
subfamily_ptpA1_pd Subfamily ptpA1 1130-1292 2.7e-15 51.1 In-house 78-249 (418) alignment 
Range on Protein: 1130-1292
Range on HMM: 78-249/418.0
IHANWIPTpGHPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPLWFP--FLSK-TKNQLKIGRFEIKIKNTEYILNKKINQRT
| ||.|    .|..||.||||| ||  ||| |. .  .  |||. .. ||    |  |.|       .|   . .  .| . ... .     ...|  | 
inanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrn

LEVvdsTGKFATRTLMHYQYSEWTGYGVPKSHAELFDLME--------IVKKSE--KPIVVHCSNGIGRSMAFIGT
. .   | .  || . .|||  |  . .|     . .|.         |.  |.   ||.|||| |.||. .|  .
irl...tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfcta
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1126-1259 3.3e-14 47.4 In-house 58-184 (297) alignment 
Range on Protein: 1126-1259
Range on HMM: 58-184/297.0
QRVPIHANWIPTPG--HPHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKNTEyilNKKIN
.|  | |...  |   .. ..| .|||| .| .||| .... ||  |||  . .|.  | |. |.|      |  ...|| | . ..   .      . .
erdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp......svvqerlkagdvvveflsst...sdefd

QRTLEVVDSTGKFATRTLMHYQYSEWTGYGVPKSHA
.  |  .    .  .| . | |.  |  .|||    
rviltelqliyrsesrvvrhvqflswpdhGvpsdle
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1142-1319 1.2e-13 45.7 In-house 4-183 (198) alignment 
Range on Protein: 1142-1319
Range on HMM: 4-183/198.0
HRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTdmcTDYfPLWFPFLSKtkNQLKIGRFEIKIKNTEYILNKKINQRTLeVVDSTGKFATRTL
.|.|||| || .|  ||| |. .    ||||  . . |     .|| |...|         | | . .  |      .  |    | . ..|   .|| .
rryiatqhplretladfwqmvwetgsghivmvnddqknke...ady.pfywpttes..gtgkygslsvttktittkpdytitalil.tnnttappstrei

MHYQYSEWTGYGVPKSHA---ELFDLMEIVKKSEK----PIVVHCSNGIGRSMAFIGTECLAREVEADPT--IELTEALKHVREHRW
 |||.. |     |.       .    |. || |.    |..||||.| | .  |.  .   |  |   |  ..| |  | .|. | 
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarc
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1142-1319 1.3e-13 45.6 In-house 5-184 (199) alignment 
Range on Protein: 1142-1319
Range on HMM: 5-184/199.0
HRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTdmcTDYfPLWFPFLSKtkNQLKIGRFEIKIKNTEYILNKKINQRTLeVVDSTGKFATRTL
.|.|||| || .|  ||| |. .    ||||  . . |     .|| |...|         | | . .  |      .  |    | . ..|   .|| .
rryiatqhplretmadfwqmvwetgsghivmvnddqknke...ady.pfywpttes..gtgkygslsvttktittkpdytitalil.tnnttappstrei

MHYQYSEWTGYGVPKSHA---ELFDLMEIVKKSEK----PIVVHCSNGIGRSMAFIGTECLAREVEADPT--IELTEALKHVREHRW
 |||.. |     |.       .    |. || |.    |..||||.| | .  |.  .   |  |   |  ..| |  | .|. | 
shyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarc
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1076-1330 9e-13 42.5 In-house 23-270 (303) alignment 
Range on Protein: 1076-1330
Range on HMM: 23-270/303.0
FCNTTIESVNAsTIdKDHITESYTYLPEDKHRFPNVPCKPSTAVEViVDGqrVPIHANWIPTPGHpHRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQ
 .   .| | .  .   ...        || || .| |   . |..  |     |||...    . .. | || ||. |. ||| |...  |  ....  
iavnefekvvs.yl.ppsvsknqfvknmdknrfvdvicldhskvkl.sds..syihasyleldss.kkailtqlplshtaadfwqmiieqkvkcvllllt

KRENlTDMCT-DYFPLWFPFLSKTKNQLKIGRFeikiKNTEyiLNKKINQRTLEVvdSTGKFATRTLMHyQYSEWTGYGV-----PKSHAELFDLMEIVK
  |   ..     ||    ||   .  ...| |    |. |  | .  . . | |  | |.. .   .| .| .|    .     ||   ....|  ...
dsey.dklggdsvfprnqdflkfeersirvgef....krve..lgdgwvlkvlsv..sngdyksflhvh.hykawphnsipsdgspkfvkqiwqlqsvlr

KS--EKPIVVHCSNGIGRSMAFIGTECLAREV-EADPTIELTEALKHVREHRWNGVQTNSQLYW
|    .| |     | ||. .|   |     . . .....|   |. ||. |   ||  ||.  
kysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsv
subfamily_CG42327_pd Subfamily CG42327 1123-1270 6.8e-11 36.4 In-house 52-192 (319) alignment 
Range on Protein: 1123-1270
Range on HMM: 52-192/319.0
VDGQRVPIHANWIPTPGHP-HRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpFLSKTKNQLKIGRFEIKIKNTEYilNKK
 | .   ..|...  .      .||.| .| ..  ||| .. .     ||   .  |.  ..|..|.|         .|.   | . . .|. |   ...
dddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylP....tketldntslyGdilvtlkgrev..kdr

INQRTLeVVDSTGKFATRTLMHYQYsEWTGYGVPKSHAELFDLMEIVKK
    || ..    |  .| | || | .|   .|| ..| |. ..  |..
yaistl.llkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1237-1331 1.8e-09 31.5 In-house 87-186 (440) alignment 
Range on Protein: 1237-1331
Range on HMM: 87-186/440.0
ATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKS-----EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLYWM
 .||| .|.|  |   ||||  . .. ... |..|     . |..|||| | ||.   |  ... ||..    |..   .. .|. | . |||  |  ..
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv
subfamily_eak_pd Subfamily eak 1142-1286 2.4e-09 31.1 In-house 93-225 (332) alignment 
Range on Protein: 1142-1286
Range on HMM: 93-225/332.0
HRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFPlwfpflSKTKNQLKIGRFEIKIKntEYILNKKINQRTLEVvdSTGKfATRTL
...| |  .  .    || |...     ||.. .. |.  .    |||       ||...|| | .... |  |.. ..... | ||.  | |   |  .
rkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfp......dktreelkfGildverk..efvkrniletrllel..skGn.ethrv

MHYQYSEWTGYGVPKSHaELFDLMEIVKKSEKPIVVHCSNGIGRS
.||..  || . .|| . ... | ...|.   . ..   . . .|
lhykvfGwtettlpkye.dflalrkvmkevGvlllivmksallss
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1138-1189 2.1e-08 28.3 In-house 104-151 (350) alignment 
Range on Protein: 1138-1189
Range on HMM: 104-151/350.0
PghphRFIATQGPLTNTCEDFWMMLMQYDVEHIVMFGQKRENLTDMCTDYFP
     ..||||.|| .| .||. .... .|. |..  .. |.  . |  |..
f....kYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWq
subfamily_CG42327_pd Subfamily CG42327 1269-1330 9.4e-08 26.1 In-house 244-306 (319) alignment 
Range on Protein: 1269-1330
Range on HMM: 244-306/319.0
KKSEKPIVVHCSNGIGRSMAFIGTECLAREVEAD-PTIELTEALKHVREHRWNGVQTNSQLYW
..|  |.|||||.|.||.   | ..   |..|    .... . . .||. | . |.|  |  .
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyef
PTPc_motif_SM00404 1237-1327 1e-07 26.9 In-house 45-130 (140) alignment 
Range on Protein: 1237-1327
Range on HMM: 45-130/140.0
ATRTLMHYQYSEWTGYGVPKSHAELFDLMEIVKKSEKPIVVHCSNGIGRSMAFIGTECLAREveadpTIELTEALKHVREHRwNGVQTNS-Q
  ....... .. .   . |   .. | .| ..|... ..|||  |. || ..|  ... ..      ..| ||.. |.| | . .. |   
sgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryr.....qlslaeayefvkerR.piispnlnf
DUF1510 Protein of unknown function (DUF1510) 856-967 1.7e-07 20.1 Pfam-A 15-123 (217) alignment 
Range on Protein: 856-967
Range on HMM: 15-123/217.0
ILFVVIPVVLILVVLVIGgIVFFWNRRREEKCKE-KEAEEENEKlipERKRMEAIKEEEERVKAEREKVKKEEERLKAEEEKVKVEKEKVKAEEEKVKVE
.| . | .|..|.|.| .  ....|   ... .. .|.|.....   |..  | .||||.   .. .| ...|.. | ||.. . |.|| |.|||. . |
vLniaiaiVvvlivivaa.qllvgnskskkasadeeeeeksede...ekteeeevkeeekeaakdedkeddsesekkdeeseeeeeeekekkeeeseede

KERNKEKVKAEEE
|| .... . .|.
keteekeesnvek
0038934 (Phosphotyrosine protein) phosphatases II 1242-1331 9.8e-07 24.1 In-house 80-169 (194) alignment 
Range on Protein: 1242-1331
Range on HMM: 80-169/194.0
MHYQYSEWTGYGVPKSHAELFDLMEIV-----KKSEKPIVVHCSNGIGRSMAFIGTECLAREveadpTIELTEALKHVREHRWNGVQTNSQLYWM
..|    . ..|.. | . |.. ...|     ..... ..|||  |.||.  ...   . |       . . ||....|| | ..... ..| ..
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrl.....gmsaeeAialfrekRpgaipnqdyleal
subfamily_PTPDC1_pd Subfamily PTPDC1 1235-1331 1.7e-06 22.6 In-house 77-168 (182) alignment 
Range on Protein: 1235-1331
Range on HMM: 77-168/182.0
KFATRTLMHYQYSeWTGYGVPkSHAELFDLMEIVKKS--EKPIVVHCSNGIGRSMAFIGTECLAREveadpTIELTEALKHVREHRWNGVQTNSQLYWM
... . ...|... |. |||. |  ...|.. .|. .  |. . |||  | ||    | .  .  .      ..  .|.| ||..| . .|| .|.  .
almeqgiyvynfg.wkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelv
DUF3377 Domain of unknown function (DUF3377) 846-881 3.9e-06 16.5 Pfam-A 21-56 (74) alignment 
Range on Protein: 846-881
Range on HMM: 21-56/74.0
TVSNESSDFPILFVVIPVVLILVVLVIGGIVFFWNR
.|...|.   .. ||||.|| | .||.   ...  |
evddvsgtvnavaVviPlvLalCiLvlvytivqfkr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1272-1329 4.9e-06 20.6 In-house 228-285 (297) alignment 
Range on Protein: 1272-1329
Range on HMM: 228-285/297.0
EKPIVVHCSNGIGRSMAFIGTECLAREVEADPTIELTEALKHVREHRWNGVQTNSQLY
. ...|||| |.|||   . .. ..  .  .   . .  |...|| |   |||  |  
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfe