Gene Y41D4A.5 in Caenorhabditis elegans

Synonym: CELE_Y41D4A.5, Y41D4A.5

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
CeleP217_AA protein Get Run
CeleP217_AA_94-369 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PTPN12_pd Subfamily PTPN12 88-379 1.7e-126 416.0 In-house 2-288 (290) alignment 
Range on Protein: 88-379
Range on HMM: 2-288/290.0
EEAYTPQDYLRRFYQIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENP-EGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWK
||... ... ..|.... ..||...|..|..|.. .......|||.|||||||.|||..|..|.. ..|.||..|. . ||.|.||||.|||.|||..|.
eekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWr

MIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEEKLFDDDeYLMRCLKMENQttGECRKVHQLHYREWPDHGCPSGEKQLLNMIDL
||.|..|..||..|..|||.|.||||||||...|.  ||..|.|||||| .||| .|.|.||.|.|  .|.|||.|.||..|||||.||..|.||..|.|
miweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavddd.flirtLkveaq..kesrkvyqfhYtaWPDhgvPssakslleliel

MENIHEevspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETL-HSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGIIEEPK
.....|    ....|..||||||||||||||||...||..|||.. ...|.| ||..||||||..|||..|...|....|......|.|||| |
vrelqe....sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieekk
0050432 (Phosphotyrosine protein) phosphatases II 108-373 2.7e-85 281.7 In-house 50-304 (308) alignment 
Range on Protein: 108-373
Range on HMM: 50-304/308.0
EKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIqkdsENPEGYMNASLIQLP--GGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVEL
| |..   .  ..|  |..  .|||.||||||..|| .    ... .| |||.....  . . .|||.|.||| |.. .|.|. |..|...| |.|||| 
ellsvkplleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklven

NKIKCERYWPEQVG-ESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHeevspqDSSPILV
...||..|||. .| .|. .|.. .|| .|.   .|.| .| |...|  .|| |.|...||  |||||.|.  ..||....|... .      ...||.|
grekcaqYwplelgggsleygkftvtllseev..lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl......pggpivV

HCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLG
|||||||||||.||.  . ||...|  . .|.|..| .||.||. |||| .|..|..|... |....| 
HCsaGvGRtGtfialdllleqleke..ggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0036941 (Phosphotyrosine protein) phosphatases II 105-377 3.3e-84 278.0 In-house 18-286 (297) alignment 
Range on Protein: 105-377
Range on HMM: 18-286/297.0
VEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIqkdSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVE
  .| |.. . .  ..|  |..  .|||.||||||..|| .   .... .| |||...... | .|||.|.||| |....|.|. |..|. .| |..|||
efeellpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelve

LNKIKCERYWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQdsSPILV
|...||..|||. .|||  .||. .|| ... ...|.| .| |....  .|| |.|...||  |||||.|.  ..||..|.|.......  ..  .|.||
lgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsg..gpvlV

HCSAGVGRTGTIIAINFIREQMKAE-TLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGIIEE
||||||||.||.||.  . .|.. . . . .||. .| .||.||. .||| .|..|...... .....| ... 
HCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl
0046845 (Phosphotyrosine protein) phosphatases II 114-374 1.4e-82 272.5 In-house 16-280 (284) alignment 
Range on Protein: 114-374
Range on HMM: 16-280/284.0
AEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE--NPEGYMNASLIQLP-----GGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELN
 ..  ..|..|... .|||.||||||..|| ..  ..  .  .| |||... .       | .|||.|.||| |....|.|. |..|...| |..||| .
lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelveng

KIKCERYWPEQvGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQT-TGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvsPQDSSPILVH
..||..|||.  ||.  .||. .|| .|.   .| | .| |...|   ||| |.|...|| .|||||.|.  ..||....|.....|.    ...||.||
rekcaqYwple.gevltygdftvtllseev..kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen..lpgggpivVH

CSAGVGRTGTIIAINFIREQMKAET-LHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGI
||||||||||.||.  . ||...|  |. .|....|  ||.||  |||| .|..||..... |....|..
CsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltl
0051299 (Phosphotyrosine protein) phosphatases II 95-368 1.6e-82 272.5 In-house 8-286 (288) alignment 
Range on Protein: 95-368
Range on HMM: 8-286/288.0
DYLRRFYQIRVEQEKLRMEAEYRS----------ECAVAPQHYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDE
. |..... ..   . ....|..            .|. |... .|||.||||||..|| ..  .. .. .| |||.|...  | .|||.|.||| |...
eellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntved

WWKMIDEHRVSLVVILCKLVELNKIKCERYWPEqvGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQ----TTGECRKVHQLHYREWPDHGCPSGEKQ
.|.|. |..|...|.|.|||||...||..|||.  |.|. .||. .|| .|.   .|.| .| |...|      .||.|.|...||  |||||.|.  ..
FWrmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseev..lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLNMIDLMENIHEevspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
||... |. . ..    ....|..||||||||||||.||.  . ||...|  . .|....| .||.||  |||| .|..||..... |.
lldflrlvrkala....sgggpvvVHCsaGvgRtgtfialdllleqleke..ggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 98-386 2.6e-82 271.9 In-house 15-294 (317) alignment 
Range on Protein: 98-386
Range on HMM: 15-294/317.0
RRFYQIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLV
. |.... | |.|.    .  ..|  |..  .|||.|||||| .|| .. ... .. .| |||... |  |..|||.|.||| |.. .|.|. |..|...
sdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VILCKLVELNKIKCERYWPEqvGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevsp
| |..|.||...||..|||.  ||.  .||. .|| .|.   .... .|.|..|.  ..|.|.|...||  |||||.|.  ..||........  |    
vmLteleelgrekcaqYwpl..getltygdftvtllseee..lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale....

QDSSPILVHCSAGVGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLGIIEEPKLDLAPPV
....|.|||||||||||||.||.  . ||.. |    .|..  | .||.||. .||| .|..|...... |..|.|  .. ..| |... 
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg..gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllk
DSPc_SM00195 113-368 5.3e-81 267.2 In-house 12-262 (263) alignment 
Range on Protein: 113-368
Range on HMM: 12-262/263.0
E-AEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKC
.  . ....|  ..  ..|||..|||||..||...|. . ... | ||. |...  | ..||.|.||| |....|.|. |..|...|.|.. .| .|.||
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

ERYWPEQVGESELFGDYEITLEEEKLFDdDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVspqdSSPILVHCSAGV
.|||||. |..| ||.....| |..  . ||. .| |....... | |||.|..|..|||||.|. .|..|...  ... ...     |.||.|||||||
drywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGv

GRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|||||...|..| .....|.   .||| .|  |||||..||||..|..|....|. |.
gRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 113-368 5.3e-81 267.2 In-house 12-262 (263) alignment 
Range on Protein: 113-368
Range on HMM: 12-262/263.0
E-AEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKC
.  . ....|  ..  ..|||..|||||..||...|. . ... | ||. |...  | ..||.|.||| |....|.|. |..|...|.|.. .| .|.||
stspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekc

ERYWPEQVGESELFGDYEITLEEEKLFDdDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVspqdSSPILVHCSAGV
.|||||. |..| ||.....| |..  . ||. .| |....... | |||.|..|..|||||.|. .|..|...  ... ...     |.||.|||||||
drywpeesggketfgkisvklvevekkk.deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts....sgpivVhCsaGv

GRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|||||...|..| .....|.   .||| .|  |||||..||||..|..|....|. |.
gRtgtfvtidiilskleeekk..vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0047943 (Phosphotyrosine protein) phosphatases II 111-367 6.9e-81 267.0 In-house 23-271 (273) alignment 
Range on Protein: 111-367
Range on HMM: 23-271/273.0
RMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIqkdSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKC
..  ..  ..|. |..  .|||.||||||..|| .   .... .| |||.....  | .|||.|.||| |....|.|. |..|...| |..||||...||
slkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekc

ERYWPEQVGE-SELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQdsSPILVHCSAG
..|||. .|| |. .|.. .|| .|.   .| | .| |...|  |||.|.|...|| .|||||.|.  ..||..|.|.....|..  .  .|..||||||
aqYwpleggelsltygkftvtllseet..kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn..gpvvVHCsaG

VGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
||||||.||.  . .|...|  . .|.. .|  ||.||  |||| .|..|...... |
vgRtgtfialdllldqleke..ggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPRD_pd Subfamily PTPRD 102-368 3.8e-80 265.1 In-house 24-281 (564) alignment 
Range on Protein: 102-368
Range on HMM: 24-281/564.0
QIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSEN-PEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILC
..  | .|.... . . | | .|.  |.||| .|..||..|| ..|   .    |.||| |.    . ..||.|.||. |....|.|. |...| .|.| 
kfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

KLVELNKIKCERYWPEQvGeSELFGDYEITLEEEKLFDDdeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspQDSS
||.| .| ||..||||. | .| .|....|||||. . |  | .| .|...... | |.|.| |. .||||| |   ..||..|. .....|    .|. 
kleEkgkvkchkYWPek.g.tetygeltVtleeeeelad..yeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne....pdag

PILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
||.|||||||||||| |.|. . |..|.|  . .||.. |..|||||  ||||..|..|.|. |. . 
PivVhCSaGVGRTGtfividamlerikee..ktvDiyqyvkalrkqRnamVqteeQYiFiheaileal
0045450 (Phosphotyrosine protein) phosphatases II 88-369 1.1e-78 260.4 In-house 17-305 (307) alignment 
Range on Protein: 88-369
Range on HMM: 17-305/307.0
EEAYTPQDYLRRFYQIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE--NPEGYMNASLI--------QLPGGKTEFIAAQAPL
. .....| | ....   .  ..  .  .  ..|  |..  .|||.|||||| .|| ..  ..  .. .| ||| .        . .  |..|||.|.||
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

PATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQvGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQ-TTGECRKVHQLHYREWPDHGCPSG
| |....|.|. |..|...| |..||||...|| .|||.  ||.  .|.. .|| .|.   .|.| .|.|....   ||| |.|...|| .|||||.|. 
petvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseeh..ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpps

EKQLLNMIDLMENIHEEVspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHS-IDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
 ..||..|.......||   ....|.|||||||||||||.||.  . .|...|  .. .|..  | .||.||  .||...|..|...... ...
feelldfieevrkaleel..pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0039614 (Phosphotyrosine protein) phosphatases II 85-373 2.7e-78 258.7 In-house 16-294 (297) alignment 
Range on Protein: 85-373
Range on HMM: 16-294/297.0
LKEEEAYTPQDYLRRFYQIRVEQEKLRMEAEYrSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE--NPEGYMNASLIQLPGG-KTEFIAAQAPLPATL
|. ....   . .  ..... | |.|    .   ..|  |..  .|||.|||||| .|| ..   .  ..  | |||... .   . .|||.|.||| |.
lsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

DEWWKMIDEHRVSLVVILCKLVELNKiKCERYWPEQVGeseLFGDYEITLEEEKLfdDDEYLMRCLKMENqtTGECRKVHQLHYREWPDHGCPSGEKQLL
. .|.|. |..|. .| |.|||||.. ||..|||| .|    .||. .|| ...   .| | .| |...|  .|| |.|....|  |||||.|.  ..||
edFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkveh..ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelll

NMIDLMENIHEEVspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLG
....|......|   ... |.|||||||||||||.||.  . ||.. |  . .|..  | .||.||  .||| .|..|...... ...|.|.
eflelvrealael..pkggpvlVHCsaGvgRtGtfiaaylmleqleke..ggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0043336 (Phosphotyrosine protein) phosphatases II 100-368 5.2e-77 254.3 In-house 19-277 (278) alignment 
Range on Protein: 100-368
Range on HMM: 19-277/278.0
FYQIRVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVI
.. .. | |.|.    .  ..|  |... .|||.|||||| .|| ..  ..... .| |||.. ..  ...|||.|.||| |.. .|.|. |..|. .| 
ktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivm

LCKLVELNKIKCERYWPeqvGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspQD
|..||||...|| .|||   |.|. .||. .|| .|.   .| | .| |...|  .||.|.|...||  |||||.|.  ..||...  . .. |     .
LtelvelgrvkcaqYwp...ggsltygdftvtllkeeh..lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale....ds

SSPILVHCSAGVGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
..|.|||||||||||||.||.  . ||.. |    .|..  | .||.||...|||..|..|...... |.
ngpvlVHCsaGvgRTGtfialyllleqlekeg..gvdleeavkelreqRpgavqtpsqyrflyealleyl
Y_phosphatase Protein-tyrosine phosphatase 128-365 2.1e-76 251.8 Pfam-A 3-234 (235) alignment 
Range on Protein: 128-365
Range on HMM: 3-234/235.0
ARNRYRDILPYDKNRVEIqKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDY
 .|||.|||||||.||.. |.||.|. | ||. ...   | .|||.|.||. |....|.|. ...|...|.|..|.| .. ||..||||. .||. .||.
kknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EITLEEEKLFDDDEYLMRCLKMENQTTG-ECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHeevsPQDSSPILVHCSAGVGRTGTIIAINFIREQM
...|.|..  |..|| .| |.......  | |.|.|||| .|||||.|.  |.||..|. .|. .     ..|.|..||||||||||||..|.... ||.
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleql

KAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIA
.||    .|.. .| .|||||..|||. .|..|....|.
eaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 128-365 2.1e-76 251.8 In-house 3-234 (235) alignment 
Range on Protein: 128-365
Range on HMM: 3-234/235.0
ARNRYRDILPYDKNRVEIqKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDY
 .|||.|||||||.||.. |.||.|. | ||. ...   | .|||.|.||. |....|.|. ...|...|.|..|.| .. ||..||||. .||. .||.
kknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltygdi

EITLEEEKLFDDDEYLMRCLKMENQTTG-ECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHeevsPQDSSPILVHCSAGVGRTGTIIAINFIREQM
...|.|..  |..|| .| |.......  | |.|.|||| .|||||.|.  |.||..|. .|. .     ..|.|..||||||||||||..|.... ||.
kvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk....eaksgpvvVhCsaGvgRtgtfvaldilleql

KAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIA
.||    .|.. .| .|||||..|||. .|..|....|.
eaeee..vdvlqivkelRkqRpgmvqsleqYiflykail
0045098 (Phosphotyrosine protein) phosphatases II 106-370 2.8e-75 248.5 In-house 13-274 (278) alignment 
Range on Protein: 106-370
Range on HMM: 13-274/278.0
EQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEiqkdsenpeGYMNASLIQLPggKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVEL
 ...|..   .. ..|. . ....|||.|||||| .||          .| |||.|. .  ...|||.|.||| |.. .|.|. |.... .| |..||||
fefllllgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

NKIKCERYWPEqvGESELFGDYEITLEEEKLFddDEYLMRCLKMENQ----TTGECRKVHQLHYREWPDHGCPSGE--KQLLNMIDLMENIHEEVSPQ--
...||..||||  |.|. .||...||..|. .  |.| .| |...|     ...|.|.|..|||  |||||.|| .  |..|.... ... .... ..  
grekcaqywpe..ggsltygdftvtllseevl..ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

-------DSSPILVHCSAGVGRTGTIIAINFIREQMkaEtlHSIDIFGLVMTLRKQRAS-MVQTQDQFQFVHRCIASYCRR
       .. |.|||||||||||||..|.  ..|..  |  . .|..  | .||.||   .||...|..|...... . .|
sslllldsggpvlVHCsaGvgRtGtlvaaylmlell..e..ggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRB_pd Subfamily PTPRB 107-370 1.5e-74 245.7 In-house 31-287 (293) alignment 
Range on Protein: 107-370
Range on HMM: 31-287/293.0
QEKLR-MEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVE
 |.|. .. .   ..| ...  |.|||..|||||..||.... ..|. . |.||. |.    . ||||.| ||| |.|. |.|. |...| .|.| .|||
yeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiivmltqlve

LNKIKCERYWPEQVgESELFGDYEITLEEEKlfDDDEYLMRCLKMENqtTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevSPQDSSPILV
  |.|||.|||..  |. |.|| ..|| .|.  . ... .| ||.|.  . |.|||.|.|.  ||||| |.  |.||...  ... .|  . ....||.|
kgkvkCeeYWPade.epvlyGdikvtlvaee..eledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie..ktaskrPivv

HCSAGVGRTGTIIAINFIREQMKAetLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRR
||||||||||| ||.. . ....      .||||.|. ||..|...|||..|. |.|.|. ...|.
hCsaGvGRtGtfialdrllqaiee..edyvdifgivaelReeRnllvqtekqYifihqcvldllrk
0040439 (Phosphotyrosine protein) phosphatases II 119-369 1.8e-73 242.5 In-house 4-247 (249) alignment 
Range on Protein: 119-369
Range on HMM: 4-247/249.0
ECAVAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEq
..|  | .  .|||.|||||| .|| ..  .. .. .| |||.| ..  |..|||.|.||| |.. .|.|. |.... .| |..||||...||..|||. 
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl.

vGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVspQDSSPILVHCSAGVGRTGTII
 |.|  .||. .|| ...    |.| .| |...|  .|| |.|....|  |||||.|.  ..||..|.......||    ...|.|||||||||||||.|
.ggsleygdftvtllsvev..kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel..pkggpvlVHCsaGvgRtGtfi

AINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
|.  . ||.. |  . .|..  | .||.||  .||...|..|...... ...
aaylmleqleke..lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_PTPN6_pd Subfamily PTPN6 83-370 2e-73 242.1 In-house 15-299 (306) alignment 
Range on Protein: 83-370
Range on HMM: 15-299/306.0
EFLKEEEAYTPQDYLRRFYQIRVEQeklrMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENPEGYMNASLIQ--LPGGKTEFIAAQAPLPAT
|. |||| .. ...   | ... |.    ..  .  . .  |.   .|||. |||.|..|| ....|   . |.||. |.  ..| ....||.|  |..|
elekeeeslekagfeeefeelqqee....akkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclett

LDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESElFGDYEITLEEEKlfDDDEYLMRCLKME-NQTTGECRKVHQLHYREWPDHGCPSGEKQ
. ..|.|. .    ..|.. | || .| || ||||..  ..| .|....|  .||  . ..| .| |... ... .|.|.|.|.|...|||||.|.  ..
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvsek..sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpga

LLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETL-HSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRR
.|.... ... .||.. ... ||.||||||.|||||.| |. . .... . |   |||  ||...|.||  .|||..|..||.. |. | ..
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 108-366 1.1e-72 239.5 In-house 28-277 (288) alignment 
Range on Protein: 108-366
Range on HMM: 28-277/288.0
EKL-RMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVEL
..|  .| .  .. .  ..   .||||.||||| .||...| . |. . |.||| |.  ..| ..||.|.||..|....|... |...| .| | .||| 
nsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktstivmltelveg

NKIKCERYWPEQvGESELFGDYEITLEEEKlfDDDEYLMRCLKMEnqTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVspqdSSPILVH
.| |||.|||.. .. ...|. ..|| |.|  . .....| | .|   ... ....|..|  ||||| |  ...||.... ... ...     . ||.||
gktkCeeYWPda.dkpknyGsvtvtlvesk..eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad....tgpiivh

CSAGVGRTGTIIAINFIREQMKAetLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIAS
|||||||||| ||.. . .....     ||..| |  ||||||..|||. |..|......|
CsaGvGrtgtFialdalidavee..edyiDvagtvaklRkqRallvqtlkqYefiyevlls
0042113 (Phosphotyrosine protein) phosphatases II 119-368 5.7e-71 234.1 In-house 2-243 (245) alignment 
Range on Protein: 119-368
Range on HMM: 2-243/245.0
ECAVAPQHYARNRYRDILPYDKNRVEIQKDSENP-EGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEq
..|  | .  .|||.|||||| .|| .. |....  .| |||.. ..  .  |||.|.||| |.. .|.|. |.... .| |....||...||..|||. 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

vGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvspQDSSPILVHCSAGVGRTGTII
 |||  .||. .|| .|.   .|.| .| |...|  ..| |.|...||  |||||.|.  ..||......... .|    .. |.|||||||||||||.|
.gesltygdftvtllseeh..lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae...dsngpvlVHCsaGvgRtGtfi

AINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|.  . ||...|  . ....  |  ||.||  .|||..|..|...... ..
aaylmleqleke..lgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 104-368 1.3e-70 233.0 In-house 23-280 (318) alignment 
Range on Protein: 104-368
Range on HMM: 23-280/318.0
RVEQEKL-RMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCK
  | |.| | |..  |  .. |   |.||| .||.||. ||..|. .....  |.||. |.    | ..|||||||| |....|.|. |   ...|.| .
seeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltq

LVELNKIKCERYWPEQvgESELFGDYEITLEEEKLFddDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHeevSPQDSSP
..|  |.|..||||..  .|. .|.  ..|.||. .  ..|..| .|.... . | |.|.| || .|||.| |.   .||...   ....    ... .|
eeergkakvhryWPsk..gsrsygklvvelkeevel..sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaq...qksgagp

ILVHCSAGVGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|.|||||||||||. ||.. . |..|||.|  .|.|. |..||.||  ||||.||..|..  .  . 
ivvhCsaGvGrtGvfiavdillerikaeal..vDvfqtvkqlreqrnlmvqtedqyefiydvlleal
0037934 (Phosphotyrosine protein) phosphatases II 119-367 4e-69 228.1 In-house 3-241 (243) alignment 
Range on Protein: 119-367
Range on HMM: 3-241/243.0
ECAVAPQHYARNRYRDILPYDKNRVEIqkdsENpEGYMNASLIQLPGGkteFIAAQAPLPATLDE----WWKMIDEHRVSLVVILCKLVELNKIKCERYW
 .|  |..  .|||.|||||| .|| .    |. ..| ||.||. ...   .|| |.||| |...    .|.|. |.... .| |..||||...||..||
siallpenlsknrysdilpydhsrvkl....eg.sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PeqvgESELFGDYEITLEEEKLFDDdeYLMRCLKMENQT-TGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEE-----VSPQDsSPILVHCSA
|    ... .||...|| .|. .||  | .| |..||   ....| |...||  |||||.|.  ..||...| . .. ||     . ... .|.||||||
p....gevtygdftvtllseehldd..ytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg.gpvlVHCsa

GVGRTGTIIAINFIREQMkaetlhSIDIFGLVMTLRKQRAS-MVQTQDQFQFVHRCIASY
|||||||.||.  . ...      ..|..  | .||.||   .|||..|..|...... .
GvgRtGtliaaylmllll......gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 113-371 4.2e-69 227.8 In-house 28-279 (281) alignment 
Range on Protein: 113-371
Range on HMM: 28-279/281.0
EAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENP-EGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCE
. .  .. . |..   .|||..|  ||. ||......||    |.||. ..   |..|.||.|.|.||.|...|.|. |..||..|.. . .| .|.|| 
gvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkCh

RYWPEQVGeSELFGDYEITLEEEKlfDDDEYLMRCLKMeNQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMidlMENIHEEVSPQDSSPILVHCSAGVG
||||..   .  .||. .. ..|.  .  .|. | .|. ....|| |.|.||.|  ||||| |.  |.||.     .....  ...   |...|||||||
rYWPddns.elkygdvtvkstaee..ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellef...rkevlkltekktkaplvihCsaGvG

RTGTIIAINFIREQMKaETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRH
|||| ||.. . .... ..|...|.  .|. |||.|  ||||  |..||.. .  .  ..
rtGtyialDrlvkave.aeleeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_PTPN13_pd Subfamily PTPN13 112-364 1.2e-68 226.3 In-house 23-265 (273) alignment 
Range on Protein: 112-364
Range on HMM: 23-265/273.0
MEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSEnpegYMNASLIQLPGGKTEF--IAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIK
. .  ..| .   .. ..||||..||||. ||......     |.|||||..| || |.  ||.| ||| | .. |.|. | ........ . .| .|.|
lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvk

CERYWPEQVGESeLFGDYEITLEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspqDSSPILVHCSAG
|.|||||. ... |     ...| .|. . |.. .| |..... .|| |.| .|.. .||||| ||  ..||...  . ....     |..||.||||||
chrywPesknkk.lkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.....dagPivvhcsaG

VGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
.||.||.|.|. . . .. ..  ..|.  .| .||.|| ..|||.||. ||.. |
iGrsGtlitidvvlglierdk..efdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 104-368 1.1e-66 220.1 In-house 26-283 (319) alignment 
Range on Protein: 104-368
Range on HMM: 26-283/319.0
RVEQEKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKL
. | ..|..  .   . |  ..   .|||..||.||. || ...  . .   |.||| |.    ...|||.||||  |....|.|. |...| ||.|.||
ekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeessivvmltkl

VELNKIKCERYWPEQvgESELFGDYEITLEEEKlfDDDEYLMRCLKMeNQTTGEC--RKVHQLHYREWPDHGCPSGEKQLlnmIDLMENIHEEVSPQDSS
||  |.|...||||.  . | .| . .|||||.    ..| .| ||. |. ..|   |.| . .| |||||. |   ..|   .||...|.. .. ..| 
veklkvklkkywpee..nfeeyGrlivtleeee..eledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatsl...ldllkrirksrektqsg

PILVHCSAGVGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|| |||||||||||| |... . |..| |..  .|.|  | .|| ||  |||...|..|..  .  . 
PivvhCsaGvGRtGtfivldamlervkeegv..lDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPN23_pd Subfamily PTPN23 107-371 2.3e-66 218.6 In-house 25-283 (288) alignment 
Range on Protein: 107-371
Range on HMM: 25-283/288.0
QEKLRMEAEYRSeCAVAPQHYARNRYRDILPYDKNRVEIQkdsENPEGYMNASLIQ-LPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVEL
..|   ||. || .|.|  .  .||.|||||||.||| ..   .. . |.||| .. |  |  .|||.||||. || ..|.|. | ..|..|.| .  ||
eqkqdkearkrs.iaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeel

NKIKCERYWPEQVGESELFGDYEITLEEEKlfDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQDSSPILVH
.| |..|||||. ||.. |||...||....  . ...  | ||.| . . . ..|  |.. .||..| |.  ..||...| .|. .|.|  .   |..||
gkpkvdrYwPedkgetvkfgdlsvtlksvr..etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvh

CSAGVGRTGTIIAI-NFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRH
|||||||||..  .   .||  | . |  .||  .| .||.||  |||...|..|.   .  . || 
CsaGvgRtgvfalvyaavrelekgngl..ldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 110-368 3.2e-66 218.5 In-house 31-283 (305) alignment 
Range on Protein: 110-368
Range on HMM: 31-283/305.0
LRMEaEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENP-EGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKI
| .| |   .     .. |.||...| ..|..|. ........ . |.||| ..   .| ..|.||.||. |....|..| | .|| .|.|.|||| .| 
lyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkd

KCERYWPEQVGESELFGDYEITLEEEKLFDDdeYLMRCLKMEN-QTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHeevSPQDSSPILVHCS
||..||||...|.. ||.....|..|| . |  |..| ||. . ..  | | | |..  .||||| |     ||..|. ... .   . .   |.|||||
kCrqYWpesktekkefgefsvelksektasd..yieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdq...kkdkgvpllVhCs

AGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|||||||. ||..   |..|.|   ..|.|... .||..|  ||||.||..|.|  .. . 
agvgRtGvfiavdialerlkkE..evvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 96-367 7.4e-66 217.4 In-house 29-289 (298) alignment 
Range on Protein: 96-367
Range on HMM: 29-289/298.0
YLRRFYQIRVEQEKLRMEaeyRSECAVAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVS
|   | ...  ..... |    .| | .|.   .||| ||...|. || ..| |...   |.||| ..   |.. |||.||||..|. ..|.|. |. ..
yalefqrlnsvsseieee...ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

LVVILCKLVELNKIKCERYWPEQvgESELFGDYEITLEEEKLFDDdeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLnmiDLMENIHEev
 .|.| .|.||.|.|...|||..  ..| .|. ...| ... | |  . .| ||...... . |.|.|||. .|||.| |. .. .|   ||.....   
tiVmltnleeldktkyhkywPde..gketygeitvsllskeefad..livrklkvskkkeekerevrqlhftsWpdkgvpenatsvl...dllrkvra..

SPQDSS--PILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
|.|..   |..|.|||||||.|| |||. . |..|.|  ...|.|  | .|||.|. .|||..|. |..  .  .
sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkke..qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlea
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 119-368 1.1e-64 213.7 In-house 41-288 (325) alignment 
Range on Protein: 119-368
Range on HMM: 41-288/325.0
ECAVAPQHYARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILcKLVELNKIKCERYWPEQ
. |. |.  |.||.......||.|| ..   ..|.  |.||| ..   .|  |.||||||.||... |... . | |.||.|   ..|.| .|  |||..
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvl.neldlgkdrcavywpke

VGESELFGDYEITLEEEKLFddDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSP--QDSSPILVHCSAGVGRTGT
.|.|  ||  |. |   . .   .|..| |.. .   || | |.|.... |.| | .     |.....|.....| |    . |.||||||||||||||.
mgksktfGglevklrtieei..sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGv

IIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
 |..  . ...  |.  ..|||| |  |||.| |||.| ||. ... ... . 
fislysalakviees..rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPN3_pd Subfamily PTPN3 111-366 1.6e-64 212.6 In-house 26-273 (280) alignment 
Range on Protein: 111-366
Range on HMM: 26-273/280.0
RMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSEnpeGYMNASLIQL--PGG--KTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELN
| . .   ..|  |.  ..||||||||||. ||.... .     |.||. ...  |.    . .||.| ||. |  ..|.|. |...||.|.|  |||  
rkkpglaisaarkpenlsknryrdilpydatrvklkeset...dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

KIKCERYWPEqVGESELFGDYEITLEEEklFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHeevsPQDSSPILVHC
..|| .||||  ...  .|......|.|    . .|..| | .....| | ||..|| | .||||| |. ....|.... .....      ...|..|||
rvkChqyWPe.tedeleygefsvkceke..detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr....sgkeePvvvhC

SAGVGRTGTIIAINFIREqmKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIAS
|||.|||| .|...      . |. ... .  .| |.| |||..|||..|..||  .|  
saGigrtGvlilletala..lieaaepvypldivrtmrdqramlvqtasqykfvCeailk
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 108-371 5.7e-64 210.8 In-house 10-271 (274) alignment 
Range on Protein: 108-371
Range on HMM: 10-271/274.0
EKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDS-ENP-EGYMNASLIQLPGGKT-EFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVE
| | . ...  |    . .  .|||..||| .. || ....| |..   |.||  |. .....  ..|.| ||| |....|.|| ...|...|.| || |
eflelPlnfdqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklke

LNKIKCERYWPEQVGE--SELFGDYEITLEeeKLFDDDEYLMRCLKMENQTTgeCRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSpQDSSPI
 |. ||..|.|.. .   || .|| ||. |  |  . ..| .| | .....   .|.|.   | .||||  |   ..||.... .|. .|| . .  .|.
aneqkCavyfPdaedyeiserygdveikve..kiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeen.aklapv

LVHCSAGVGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRH
.||||||.||||  |||.    |...|.   .|....|  || .|  ||||..|....|| .. | .| 
vvhCsaGiGrtGcfiaisiavrqlreei..vvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 123-371 2.7e-62 205.2 In-house 17-267 (270) alignment 
Range on Protein: 123-371
Range on HMM: 17-267/270.0
APQHYARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQ-LPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGE
| .. . |||.||||  . || ... .|...  |.||  ..   | |...|||..|||.|| ..|.|| |..|. .|.. .|.| .. |||||||....|
aargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

SELFGDYEITLEEEKLFDDDEYLMRCLKMEnqTTGECRKVHQLHYREWPDHGCPSGEK---QLLNMIDLMENIHEEVSPQDSS-PILVHCSAGVGRTGTI
.  . | .|.   ..   .. |... |..|  ..|| |..   .| .||||| |. |    .  ... .......  . .| . |.|||||||||||||.
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

IAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRH
||.... . .. .  ...|.  ..  |||.|  .||. .|..|... .. |..| 
ialDiavrlLeet..kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
subfamily_PTPN14_pd Subfamily PTPN14 111-369 2.1e-61 202.6 In-house 34-297 (300) alignment 
Range on Protein: 111-369
Range on HMM: 34-297/300.0
RMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENPEGYMNASLIQLPGG--KTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKI
.....   ..|  |.   .||..|.|||..||||..   || .||.||| |. . |  . ..|.||.||. |. ..|.|. |. |.|.|.| .  |  | 
kkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgke

KCERYWPEQ--VGESELFGDYEITLEEEKlfDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQD-----SSP
|. .|.|..    ..  || ...| .  .  | | .  ..||..   ..| |.|. | | .|||||.|.  |. |. .. .. . .... .      . |
ksfkyfPkleskkktvefgkfkvttkfse..dsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

ILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
.|||||||||||| .|  ... . .. .  ..|||   . .||.|| ..|||  |..||.. .  | .
vlvhCsaGvGrtGvlilsdlliatlehn..eeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPRA_pd Subfamily PTPRA 118-367 3.3e-61 202.0 In-house 50-294 (330) alignment 
Range on Protein: 118-367
Range on HMM: 50-294/330.0
SECAVAPQHYARNRYRDILPYDKNRVEIQ-KDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPE
 | |   .   .||. .||||| .|| .. |. ..   |.||| |.    | .||||| |.  |....|.|| |.. . .|.| .| | .. ||..|||.
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

QVgeSELFGDYEITLEEEKLFDDdeYLMRCLKME--NQT--TGECRKVHQLHYREWPDHGCPSGEKqllNMIDLMENIHeEVSPQDSSPILVHCSAGVGR
.   .  .|.  ...|.|..  |  | .| . ..  ...    . | |.|.|.. ||| | |.  .    |..|..... .. .| ..|| |||||||||
eG..lvtyGnirvevedetvlvd..ytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi...Gmlkllkkvk.klnqqsagpivvhcsaGvGr

TGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
||| |... . |..||| .  .|.|. |  ||.||. ||||. |..|... .  |
tGtfivldavlervkaerk..vdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Ptp69D_pd Subfamily Ptp69D 106-368 1.9e-60 199.6 In-house 27-286 (307) alignment 
Range on Protein: 106-368
Range on HMM: 27-286/307.0
EQEKLRME-AEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKD-SENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLV
| |||  .  .  .. .       .||| || ..||.|| ..|   ..   |.||| |.    | .|||||.|. ||....|.|| |  | |.|.| .| 
eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlt

ELNKIKCERYWPEQvgESELFGDYEITLEEEKLFddDEYLMRCLKMENQT-----TGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVspqd
| |. ||..|||..  .   .||  ..| .|.    ..| .| |.. ..        . ||| | || .|.|   |   . ||..|. ......      
eknrkkcakYWpie..devqygdilvklvseekh..sdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln....

SSPILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
 |||.|||||||||.|...|.. . .|.|||  ...|||  |  ||.||  .||  .|..|..| .. | 
rsPivvhCsaGvgrsgifvaldsllqqlkae..dkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPRN_pd Subfamily PTPRN 94-366 2.9e-60 198.5 In-house 22-290 (297) alignment 
Range on Protein: 94-366
Range on HMM: 22-290/297.0
QDYLRRFYQIRVEQEKLR-MEAEYRSE-CAVAPQHYARNRYRDILPYDKNRVEIQKD-SENPEGYMNASLIQLP-GGKTEFIAAQAPLPATLDEWWKMID
.|.|.   ... | | |   ||| ...  | |..   .||....||||..||..... |.. . |.||| |      .. .||.|.||..|. ..|.|. 
edhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvw

EHRVSLVVILCKLVELNKIKCERYWPEQvgESELFGDYEITLEEEKLFDDDeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMEN
|. | ..| |..| | .  .|.||||..   ||... ||. |  |... || ||.| . . |  | | | | |.|.  ||..|.|.  | ||..   .. 
eqGvvvivnltrleeegvkqckrywpde..Gsevyhiyevhlvsehiwcdd.ylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk

IHEEvspqDSSPILVHCSAGVGRTGTIIAINFIREQMKaETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIAS
 .       |.||.||||.|.||||. |.|... ....   .. |||   .  || ||. .|.|.|||.|.  ..| 
syrG....rscpivvhcsdGaGrtGvyilidlvlnrll.kGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPRG_pd Subfamily PTPRG 113-367 9.1e-60 197.4 In-house 34-286 (563) alignment 
Range on Protein: 113-367
Range on HMM: 34-286/563.0
EAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENPEG--YMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKC
. .   | . .|.   .||| .|..||. ||.... ... .   |.||. |.    . .|||.| ||. |.| .|.|| |..|...|.. .||| .. ||
skdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkc

ERYWPEqvGESELFGDYEITLEEEKLF---DDDEYLMRCLKMENQTT-GECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMenihEEVSPQDSSPILVHC
..|||.   ||| .|  ..||.||. .      .  .. ||....    . ..| | || .||||| |. .   |...       .   ...  ||.|||
dvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks....saankaeaGPivvHc

SAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
||||||||| |... . .|...|  .....||.. ..| ||  .|||..|..|.|  . . 
saGvgrtGtyivldtllkqiqqe..navnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 115-369 1.6e-59 196.3 In-house 33-278 (315) alignment 
Range on Protein: 115-369
Range on HMM: 33-278/315.0
EYRSECAVAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERY
 ||   |  .. . .|||..|||.|..|| ..  | .  . |.||| |.       .||.|.||.|..|..|.|. ...|. .|.. |. | .|||| .|
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqy

WPEQVGESELFGDYEITLEEEKlfDDDEYLMRCLKMENqtTGECRKVHQLHYREWPDHGCPSGEKqllNMIDLMENIHEEvSPQDSSPILVHCSAGVGRT
||.. ..|  || ....| . .   | .  .| | . .  . | |.| | ...||||.| .        .. |. ..  .   ..  ..|||||||||||
wPdrkadsvefGsikvellsle..adtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqts...sllklikevkad.ngkkefsllvhcsaGvGrt

GTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
| .|.|. . .|.| .  .|.|.| .| .||..|  .|||.... |..  .  .  
Gvvisidevvaqikrt..rsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN1_pd Subfamily PTPN1 109-364 2.9e-59 195.2 In-house 14-267 (290) alignment 
Range on Protein: 109-364
Range on HMM: 14-267/290.0
KLRMEA-EYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSEnpeGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNK
..| || ... . |  |.  ..|||||. |||. |.......     |.||||..|.  | ..| .| ||| | | .|.|. |..   ||.| |.|| ..
dirkeasdfptreaklpenrnlnryrdvspydhsrikleradn...dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeq

IKCERYWPEQVGESEL-FGDYEITLEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENihEEVSPQDSSPILVHC
||| .|||..  |.|| . | .....  .  . ..| .| |..||..| |.|.. . ||  ||| | |.   ..|...  . .    .  .|  | ..||
ikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvre..sGslssdvGpavihc

SAGVGRTGTIIAINFIREQMKAE-TLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
|||.||.||.. .. .  .....  | |.||   .. |||.|  ..||.||..| .  |
saGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylai
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 121-367 3.2e-59 195.2 In-house 4-241 (250) alignment 
Range on Protein: 121-367
Range on HMM: 4-241/250.0
AVAPQHYARNRYRDILPYDKNRVEIQKDS-ENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIkCERYWPeqVG
|  ||   .||| ||...|. || ..|.. ..   |.||| ..   ..  |||.|.||.||. ..|.|. |. .. .|.| .|.| .|  ...|||  | 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP..ve

ESELFGDYEITLEEEKLFDDdeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLnmiDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAI
..| .||  ..| ... | |  | .| ||. ...  . | | |||.  ||| | |   .  |   .|..... .    ...|..|.|||||||.|. |||
kaekyGdvtvsllskeefad..ytkrklklskakkaderivrqlhfvvWPdkgvPevatavL...ellkkvqasqqqagnaPvivqCsaGvgrsGafiai

NFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
. . |..| |  . .|.| .. .|||.|  .|....|. ||.. |  .
davlerlkke..kvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 126-368 5.1e-59 194.7 In-house 43-276 (515) alignment 
Range on Protein: 126-368
Range on HMM: 43-276/515.0
HYARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELF
 . .|||..|||||..|| ..   .||.  |.||| |.       .||.|.|..|..|..|... ...|. .... || | .|||| .|||.. |.|  |
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GDYEITLEeeKLFDDDEYLMRCLKMENQTTgeCRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSpqdsSPILVHCSAGVGRTGTIIAINFIRE
| ... |    |  . . . | |..  .    .| | | |. ||||.| |   . || .|  .   |....     |...|||||||||| .|.|. .  
Gsikvelv..sleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt....hpliihcsaGvGrtGvvisidsvva

QMKaeTLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
..|  | ...|.| .|  .|..|  .||||.|. |..  .  . 
hak..ttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 112-368 8.9e-58 190.4 In-house 32-283 (290) alignment 
Range on Protein: 112-368
Range on HMM: 32-283/290.0
MEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSENP---EGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKI
 | |.  . .....   .||...|..|| ||. ... |...   . |.||. |.    | ..||.|.|.. || ..||.|....|. .|.|.. .| .| 
gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkv

KCERYWPEQvgESELFGDYEITLEEEKLFDddEYLMRCLKMENQTT-GECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvspQDSSPILVHCS
||  |||..  ... .| ..|.| .|. ..  ||  | |...|... |....|.|..   |...|    ..  | .|  |....     .   .|.||||
kCqqYWpds..dtkaygefsikllneetln..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrk...rgntsivvHCS

AGVGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
..|||... .|..   ...| |    ||.| .. ..| |.  .|||..|.|.... . .| 
dtvgrsavfcaaattinkckteg..vidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 116-367 6.8e-57 187.9 In-house 40-283 (297) alignment 
Range on Protein: 116-367
Range on HMM: 40-283/297.0
YRSECAVAPQ-HYARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIqlPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKiKCERY
 ...     .  . ..||..|||||..||...   ..|.  |.||| .  .| | ..|. | | .||....|.|. ...|| .|.| .. | .| || ||
iqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfv..kgnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPEQVGESelFGDYEITLeeEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSgEKQLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRT
|...   .  |||  ..|  . . .   .. | |..... .   | |.| .. ||||.  .  ...   ...|....... | . ..|.||||.||||||
Wsdkgvtt..fGdvsvvl..lsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaver.kdsassllklisevrkdfsqnaegPllvhclaGvGrt

GTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
| ...|. .  ..| |  ...||||||  ||..|  .|||..|..||.  .  .
gvlltidsvvaeakre..kevdifglvkklrqerpylvqtkeqykfvyvavlea
subfamily_PTPRK_pd Subfamily PTPRK 119-368 1.8e-56 186.3 In-house 36-277 (314) alignment 
Range on Protein: 119-368
Range on HMM: 36-277/314.0
ECAVAPQHYARNRYRDILPYDKNRVEIQKDSEN-PEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQ
..|   .. ..||. |||.||. || ..   ..    |.||.||      ..||..| ||. |. ..|... ... . .|.| .|||  ..|| .||||.
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

vgeSELFGDYEITLEEEKLfdDDEYLMRCLKMEN--QTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvspqDSSPILVHCSAGVGRTGT
   .| .|| ...| | .|  . |...| ...|.  ..  | |.|.|...  ||||. |  .. ||...  ... .||    .  .|.|||||| |||||
...tevygdikvelvetel..laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee....eaGrivvhCsaGaGrtGt

IIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
 |||. . . .. | .  .|.|  | |||...  ||.|..|..|..  |   |
fiaidivldmieregv..vdvfnavktlrsrkvnmveteeqykfiydvileac
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 105-364 1.9e-56 186.7 In-house 29-287 (319) alignment 
Range on Protein: 105-364
Range on HMM: 29-287/319.0
VEQEKLRMEAEYRSECA-----------VAPQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHR
..... ..|.|.|  |              .|   .||. .||..|||.| ... . |.   |.||| ..    |  .|||| ||. ||...|.|| |..
fdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyn

VSLVVILCklvelnKIKCERYWPEQVGESELFGDYEITLEEEKlfddDEYLMRCLKMEN-QTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIH
.| .|.|       | || .||| .. . |  .. .... ||     .|| .| ... .     . ||..| |.. |||.| |    .|. ... .. ..
cstivllt......kdkcsqywplkivikeerfkvkvdsveet....aeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhlt

EEVspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
.    ..  .|.|||||||||||. |... . ..|| |    .|.. .|  ||.||  .||   |..|..  .
ske..nhranivvhcsaGvGrtGvyivldvlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_PTPN9_pd Subfamily PTPN9 108-370 3.1e-56 185.6 In-house 23-292 (297) alignment 
Range on Protein: 108-370
Range on HMM: 23-292/297.0
EKLRME-AEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVEL
...| | .| . ...  .    .||| |.| ||. || ..| .| .   |.||. ..    |  |||.| ||. | ...|.|. |..|  .|.  ..|| 
aeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvver

NKIKCERYWPEQVGESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIH----EEVSP-----
 ..|| .|||.. ..|. |||....  | .    ..| .| |...| .|.| |||    .  |||.| ||  ..||.... . .      .|...     
grlkcgqyWpleeessaefgdlsvsnvevee..eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkgh

QDSSPILVHCSAGVGRTGTIIAINFIREQMKAetLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRR
 .  ||.||||||.||||| |....  ....   .  .|..  | .||.||| ..||..|..| . ..  |  .
psgPPivvhcsaGiGrtGtfitldiclsrlee..vgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 123-364 1.8e-55 183.4 In-house 22-251 (284) alignment 
Range on Protein: 123-364
Range on HMM: 22-251/284.0
APQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCklvelnKIKCERYWPEQVGES
 .|   .||. .||..|||.| ... . |.   |.||| |.    |  .||.| ||. ||...|.|| |...| .|.|       | || .||| .. . 
ldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplkivik

ELFGDYEITLEEEKlfddDEYLMRCLKMEN-QTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVspQDSSPILVHCSAGVGRTGTIIAIN
|  .. .... ||     .|| .| ... .     . ||..| |.. |||.| |    .|. ... .. ...    .. ..|.|||||||||||. |...
eerfkvkvdsvees....eeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske..nhranivvhcsagvgrtgvyivld

FIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
 . ..|| |    .|.. .|  ||.|| ..||   |..|..  .
vlldrmkeek..qvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 117-367 2.3e-55 182.6 In-house 38-277 (287) alignment 
Range on Protein: 117-367
Range on HMM: 38-277/287.0
RSECAVAPQHYARNRYRDILPYDKNRVEIQkdsENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPE
    ..|.|   .||...||..|..|| ..   .. . |.||. |.    | .||.|..|.  |. ..||.||...|. .|.||.. | .. .| .||||
evthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe

QvgESELFGDYEITLEEEKlfDDDEYLMRCLKMENQT-TGECRKVHQLHYREWPDHGCPSGEKQLLNMIDlmENIHEEVSPQdSSPILVHCSAGVGRTGT
.  .| ..|.|.|.| .|.    ..|..| |...|.. .|. ..|.| .. .|...|  .  .  | .|.  | ....  .   ..|.||||..|||...
e..ksvvlGeyniellnee..vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie..emyktqrkrg.ntsivvhCsdtvGrsam

IIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
 .|..   .. | |    ||.| ..   | |.  .||| .|..|.   .  |
fcaaattinkckteG..viDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 127-364 9.5e-54 177.4 In-house 50-275 (315) alignment 
Range on Protein: 127-364
Range on HMM: 50-275/315.0
YARNRYRDILPYDKNRVEI-QKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQvgeSELFG
  .||| .|..||| ||..   . ..   |.||..|.    |  .||||.|..|.....|... |. .. .|.| .||| .| |.|.|||..     ..|
kqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyG

DYEITLEEEKLFddDEYLMRCLkmENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSpqdsSPILVHCSAGVGRTGTIIAINFIREQ
 . .|. .|. .  .|| .| |        . |.| ||||  ||| | |     |.|.|  .   |..      ..|.|||||||||||| |... . .|
kitvtrkseevn..teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv....gaivvhcsaGvGrtGtfitldavldq

MKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
..|| .  ||.. ..  .|..|  |||. .|.||..  .
aeaena..idvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 126-369 4.6e-51 168.3 In-house 38-278 (287) alignment 
Range on Protein: 126-369
Range on HMM: 38-278/287.0
HYARNRYRDILPYDKNRVEIQKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQvGESELFG
   .||| |.||.|..|| . ...|    |.||  .     . .|||||.|..||. ..|... |.|.. |... . ||  . || .||||.     . |
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPer.evPmrvG

DYEITLEEEKLFDDDeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNM-IDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIRe
 | ..| . .  . . | .|.|.. .  | |.| |.||.. .|||.. .     |. . .|  ..|  . . ..  |..||...|.||.|...|.  .  
GysvvlldydikePe.ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv.

QMkAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
..  | |  .|.   |. ||..||..||.  |....   ...| .
sr.ledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 108-368 6e-48 158.1 In-house 22-293 (301) alignment 
Range on Protein: 108-368
Range on HMM: 22-293/301.0
EKLRMEAEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSE---NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVE
..|. . . ...  .  .. | ||...| .||.||. ... ..     . |.||| |.    |..|||||.|.  || ..|..| ..... .|....| |
kelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlke

LNKIKCERYWPEQVGESELFGDYEITLEEEKLFDD---------------DEYLMRCLKMENQTtgECRKVHQLHYREWPDHGCPSGEKQLLNMIDlmEN
  | |||.|||.   ||| ||  ..|| .|. . |               . |..| .|....   . ..| ||.  .||..|     .  |. ||  . 
gtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqvid..dv

IHEEVSPQdSSPILVHCSAGVGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
|| . ..   .|..||||..|.|.|. ....   || |||.   .|.|... ..|...  .|.| .|. ...  |  | 
ihrqqkig.ggpvvVHCSdtVsrsGvYcsvsiglEQckaegV..VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 114-364 1.5e-47 156.9 In-house 21-262 (283) alignment 
Range on Protein: 114-364
Range on HMM: 21-262/283.0
AEYRSECAVAPQHYARNRYRDILPYDKNRVEIQKDSEnpeGYMNASLIQLP---GGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKC
 .  ...|.| ..   ||...|.|.|..|||.. .|.    |.||. | .      . ..|.||.||  |  ..|||. ..... .|.| || | ..|||
pdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

ERYWPEQvGeSELFGDYEITLEEEKlfDDDEYLMRCLKMENQTTGECRK-VHQLHYREWpdhgCPSGEKQLLNMIDLMENIHEEVSPQDSSPILVHCSAG
 .|||.. | || .|.. .||..|     . . .. | . .... .    .    . .|       ||.  .| .  .. .      .  .||.||||.|
sqyWPkr.G.sedyGeftvtlrket..tsnsfiikelllrvnssakstlllahyqvidW....leygeqaiinslvkfnkvislqteskkgPivvhCstg

VGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
.|||.. ||.    .....|..  .|.|  |  .|.||  .|||.||...||  .
iGrtavfiaasasvkdaltesv..vdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 128-368 2.7e-47 156.3 In-house 43-277 (307) alignment 
Range on Protein: 128-368
Range on HMM: 43-277/307.0
ARNRYRDILPYDKNRVEIQKDSENpEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDY
 .|||.|.   ||.|. .. |      |. |  . .      ||.|| || .|  ..| |. ...|  |..|||..|| |||||.||| . |.   ||. 
dknryqdvkcqdkgrivvkfdgla.sdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvfgea

EITLEEE----KLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEkqlLNMIDLMENIHeevspQDSSPILVHCSAGVGRTGTIIAINFIR
  |.  .    | .  || |.   ... . ....| ...| . .|||.|.|  .   |. |.|.| ..      |  |..|||||||||.|||.|| ...
pntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavr.....ydtnpvvvhcsaGvGrsGtivaislvq

EQMKAeTLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
..| |      |.  ||  ||.||   .||. |. ..|| . .| 
dkmia.Ginckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 127-364 1.7e-46 153.3 In-house 4-235 (237) alignment 
Range on Protein: 127-364
Range on HMM: 4-235/237.0
YARNRYRDILPYDKNRVEIQKDSENpEGYMNASLIQ-LPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQvGESELFG
 ..||| .|  ||..|| ..    .   |.||. .. . |   ..|||| || .. |..|.|. . . |..|.|  |.| |..|| .|||.   . . .|
kiknrygnivaydhsrvvlkgagsg.sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpaayg

DYEITLEEEKLFDDdeYLMRCLKMENQT-TGECRKVHQLHYREWPDHGCPSGEKQLLNMIDlmeNIHEEVS-PQDSSPILVHCSAGVGRTGTIIAINFIR
 . ..|  .. | |  | .|.| . ...   | | .|| ..  |||.| |     || .     || ..    ..|.| ..|||||||||| .. |. . 
vltvslkkkeefsd..ytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrk...niinrsphvsesgpwiihcsagvgrtgiflvidaml

EQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
 | | .  . .||.  | .. ..|  ..||.||. |.|. |
rqakek..kvvdiynyvysieedrpyiiqtkdqyvfihqti
0051429 (Phosphotyrosine protein) phosphatases II 153-373 6.6e-46 152.4 In-house 4-230 (272) alignment 
Range on Protein: 153-373
Range on HMM: 4-230/272.0
EGYMNASLIQLPGG---KTEFIAAQAPLPATLDEWWKMiDEHRVSLVVILCKLVELNKIKCERYWP----------EQVGESELFGDYEITLEEEKLFDD
.|| ||. .  .|.   .  ......|||.| ...|..  |.... .| |....|... ||.||||          . . .. |.|.. .|| .|.|..|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

deYLMRCLKMENQ-TTGECRKVHQLHYREWPDHGCPSGEkqLLNMIDLMENiheevspqdSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHS-----
  |..| | .... ..|| |.|..|||. ||||| |. .  ||....|. .         . |.|||||||..||||..|.  . ... .||        
..yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

-IDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHLG
 . ... |  ||.||. .|||..|..|...... . |..|.
nlyleeaveelraqrpgavqteeqylflyeallellrslls
subfamily_CG7180_pd Subfamily CG7180 100-366 2e-45 149.7 In-house 14-288 (296) alignment 
Range on Protein: 100-366
Range on HMM: 14-288/296.0
FYQIRVEQEKLRMEAEYRSECAV--APQHYARNRYRDILPYDKNRVEIQK-DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLV
 ...  ..|    .     .||     .   .||. ...|||.||| ..| | |. . |.||. ..    | |.|  .||   |.||.|... .. .| |
kfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VILCKLVELNKiKCERYWPEQVgeSELFGDYEITLEEEKLFD-DDEYLMRCLKM-------ENQTTGECRKVHQLHYREWPD-HGCPSGEKQLLNMIDLM
|.|.|  . .| ..  |||..    | .|. .. . ||| .     . ..  |.       |.| . | | |......||.  . .|.  . |....  .
vvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrv

ENIHEEV-SPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIAS
. . |.|   .. .|..|..| |..|.|  .||.   |... |  . .|.|. | |||..|  .|.. ......   .  
rlwrekvdedpeegPvvvvssdGasRsGvylaidanlelveke..eevdvFeavktlrrsRpqLvenveeYkyiYdvlle
0041856 (Phosphotyrosine protein) phosphatases II 128-370 3.8e-45 149.1 In-house 3-173 (182) alignment 
Range on Protein: 128-370
Range on HMM: 3-173/182.0
ARNRYRDILPYDKNRveiqkdsenPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCklvelnkikCERYWPeqvgeselfgdy
 .|||.|||||| .|         .  | ||.|.  .   |.|||.|.||. |. ....|. |......| |.         .|.|||            
dknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp............

eitleeeklfdddeylmrclkmenqtTGECRKVHQLHYREWPDHGCPSgEKQLLNMIDLMENiheevspqDSSPILVHCSAGVGRTGTIIAINFIREQmk
                          . . | ..|..|  |||||.|.   .||..|. ...        .. |.|||||||||||||..|. .....  
..........................ellerlgiqylylpwpDhgvpd.ldelldfieevle........eggpvlVHCsaGvgRtgtlvaaylmkkl..

aetlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRR
     .....  | ..|..|  ||.| .|..|.....  ....
.....gvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 114-364 1.3e-44 147.4 In-house 34-275 (439) alignment 
Range on Protein: 114-364
Range on HMM: 34-275/439.0
AEYRSECAVAPQHYA--RNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKikc
 .|. ....| |.|   .|||.|. ..|  || .|.    |   |.||  |.    .  .||.|.|   | |..|... |.... .| |..|||  |   
pdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk...

erYWPEQvgESELFGDyeITLEEEKLFDDDEYLMRCLKMEN--QTTGECRKVHQLHYREWPDHGCPSgekQLLNMIDLMENIHEEVSPQDSSPILVHCSA
  ||| .  .   .||  |..  ..  .  .| .| .|. |  .||   | | |.||  |||.  |.   |   ..|..  |      ..  |..|||||
..ywpsd..aevcygd..iavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpa...qashvldflrainsandkeeygpvvvhcsa

GVGRTGTIIAINFIREQMKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
||||||||||..   ||.|.|    .|| |.|  |||||  |||.  |. |.. ..
gvGrtGtiialdialeqlklen..kvdikgivkvlrkqrkqmvqalcqyvfiynav
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 125-367 7.9e-44 144.8 In-house 42-270 (288) alignment 
Range on Protein: 125-367
Range on HMM: 42-270/288.0
QHYARNRYRDILPYDKNRVEIQkdsENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELF
.  .|.||...   |  || ..   ..|. |..| ..     |  .| ||||| .|..| |||. |  |  .|.||.|.|. | | . |.| ..||.  .
anptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GDYeITLEEEKLfDDDEYLMRCLKMENQTTGECRK-VHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspqdssPILVHCSAGVGRTGTIIAINFIR
| .  |   .|  .| . |..   . .. .|| .. | .||..||.|.| |   .  |.... ......        ||.||.|||||||||.| | .. 
grl.ctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslqk........PivvhssaGvGrtgtlililial

EQMKAETLHSidIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
|... .   .  |  |.  ||..|   .||. |. .||||.  .
eslrlddflg..irsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 127-367 1.3e-43 143.8 In-house 56-288 (305) alignment 
Range on Protein: 127-367
Range on HMM: 56-288/305.0
YARNRYRDILPYDKNRVEIQKDSenPEGYMNASLIQLPG-GKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFG
 ..|||.|.   |.. | ..| |  |  |. |  .  |   .  ||.|| ||  |.||.| |. ...|  .|.||| ||| |.|| .|||   ||   . 
itknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

DY-EI-TLEEEKLFDDD-EYLMRCLKMEnQTTGECRKVHQLHYREWPDHGCPSGEkqlLNMIDLMENIHEevspqDSSPILVHCSAGVGRTGTIIAINFI
    .  .   | .. | |  .  |..   . ..   | .|.. |||| | |      |  ..|.  |          ||.||||||.||||||.||..|
sgivvenvsgskpmerdaeiqitllnlt.ysgdqkmsvrhlqwtewpdrgvppck...ltslellsairg.....skvpivvhcsagigrtgtivaieyi

REQMkAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
 |.. ||  .   .  || .|| |||  .|.. |. |.|| .  |
leki.aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 127-363 3.3e-42 139.3 In-house 9-236 (239) alignment 
Range on Protein: 127-363
Range on HMM: 9-236/239.0
YARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQ-LPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGEselF
 |.||| .|. ||..|| ..| |..|   |.||| ..   |    .||.|  . ..  ..|.|. . |  ..|.|  |.|  | || .|||.   .   .
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...y

GDYEITLEEEKLFDDdeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLnmiDLMENIHEEVSPqDSSPILVHCSAGVGRTGTIIAINFIRE
 .  .|| . ..| |  |..| . | .    | | |.| |.  |||.| |     .|    |  .| ..  |  . | ..||||||||||... |. .  
cnlrvtlrktevfad..yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl...glrrkitkdslp.garpwvihcsagvgrtgaflvidamlr

QMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRC
| | .  ...|||  | ..|..|  |||| .|. |.| .
qakkq..ktvdifnyvkairedrphmvqtseqyvfihla
0036282 (Phosphotyrosine protein) phosphatases II 154-361 3.8e-42 139.3 In-house 3-163 (174) alignment 
Range on Protein: 154-361
Range on HMM: 3-163/174.0
GYMNASLIQLPGGKTEFIAAQAPLPatldeWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEqvgeselfgdyeitleeeklfdddeylmrclkmenQT
 |.||| . |    ...|| |.||.      |.|. |.... || |....||.. || .||||                                     
dyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................lr

TGECRKVHQLHYREWPDHGCPSGEKqLLNMIDLMENIHEEvspQDSSPILVHCSAGVGRTGTIIAINFIREQMKaetLHSIDIFGLVMTLRKQRASMVQT
. . | ..|..|  |||||.|. .. ||......|....|    .. |.|||||||||||||..|.  .  ...      .|.. || .||.||  ||||
edlerlgiqylylpwpDhgvpdlsi.llefvkfveealse...dpggpvlVHCsaGvgRtGtlvaaylmlrgll...eslvdaldlvrelRlqrpgmvqt

QDQFQFVH
..|..|..
psQyrfly
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 127-363 4e-42 139.0 In-house 8-235 (239) alignment 
Range on Protein: 127-363
Range on HMM: 8-235/239.0
YARNRYRDILPYDKNRVEIQKDSENPE-GYMNASLIQ-LPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGEselF
 |.||| .|. ||..|| ..| |..|   |.||| ..   |    .||.|  . ..  ..|.|. . |  ..|.|  |.|  | || .|||.   .   .
kaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsk...y

GDYEITLEEEKLFDDdeYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLnmiDLMENIHEEVSPqDSSPILVHCSAGVGRTGTIIAINFIRE
 .  .|| . ..| |  |..| . | .    | | |.| |.  |||.| |     .|    |  .| ..  |  . | ..||||||||||... |. .  
cnlrvtlrktevfad..yiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavl...glrrkitkdslp.garpwvihcsagvgrtgaflvidamlr

QMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRC
| | .  ...|||  | ..|..|  |||| .|. |.| .
qakkq..ktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 126-367 6.5e-41 134.9 In-house 56-282 (290) alignment 
Range on Protein: 126-367
Range on HMM: 56-282/290.0
HYARNRYRDILPYDKNRVeIQKDSEnPEGYMNASLIQlpGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFG
.. .|||.|.   || || | ||   .  |. |  ..  | |. || .| .| .|  . |.|. ...|. .|.||.|.|  | |||.|.||. ||   ||
efkknrykdvvcndktrv.ilkdGy.dGdyvhanyvk..GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

DYEITLEEEKLfDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIheevspqdSSPILVHCSAGVGRTGTIIAINFIReQ
.. ..  ||.  .|..  .. | . .. .|   |.. |. . |||.  .  .  || ..  . ..        | |. ||||||.|||||..||.    |
eitvlcseedd.kdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka........sGpvvvhcsaGiGrtGtfvaievgl.q

MKAETlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
.  .  ...|. .|| .||. |.. || . |.  . . .  .
illdG.keldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 116-363 7.7e-41 134.8 In-house 35-231 (392) alignment 
Range on Protein: 116-363
Range on HMM: 35-231/392.0
YRSECAVAPQHYARNRYRDILPYDKNRVEI-QKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNkikceryw
|.  .|  .    .|||..|||||..|| .   |  . . |.||| |.    .  .||.|.| .|.||..|.|. ...|. .... || | .        
ypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

peqvgeselfgdyeitleeeklfdddeylmrclkmenqTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspQDSSPILVHCSAGVGRTG
                                         ..| | | |. ||||.. |     ||..|  ..  .     | . |...||||||||||
......................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfG....qythpliihcsagvgrtg

TIIAINFIREQmkAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRC
 .|.|. .  .  |.. . .|.| .|  .|..|  ||||..|. |.. .
vvisidsvvah..akktrmvdvfnfvtnirrkrpymvqtkeqyafiyga
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 124-371 1.4e-39 130.7 In-house 46-290 (305) alignment 
Range on Protein: 124-371
Range on HMM: 46-290/305.0
PQHYARNRYRDILPYDKNRVEIqkDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESEL
 |.  .|||.|.   |.||| .  ..  |  |. |  .  |     || .||||  |  ..| |  ...|  . .||.|.|    ||  |.. . ..   
aqeagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

FG--DYEITLEEE-----KLFDDDEYLMRCLKM-ENQTTGECRKVHQLHYREWPDHGCPSGEKQLlnmIDLMENIHeevsPqDSSPILVHCSAGVGRTGT
|   .  |..  |     |. .| .  ..  ..  . . .. ||| . |. .||| | |. .  .   ..|.|.      |    || ||||||.||||.
feekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlai...lellekar....p.skgpivvhcsagigrtgs

IIAINFIREQMKAETLHSiDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRH
.. ...| .|. |      |   ... .|.||   .||..|. |||. |  |.|..
vvmleyildqllagqiie.dtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk
0043147 (Phosphotyrosine protein) phosphatases II 151-361 1.5e-39 130.8 In-house 3-154 (172) alignment 
Range on Protein: 151-361
Range on HMM: 3-154/172.0
NPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLvelnkikcerywpeqvgeselfgdyeitleeeklfdddeylmrclkmE
... |.|||.. |.   ..||| |.||. ||.. |.|. |. ....| |..|                                               .
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

NQTTGECRKVHQLHYREWPDHGCPsGEKQLLNMIDLMENIHeevSPQDSSPILVHCSAGVGRTGTIIAINFIReqmkaetlHSIDIFGLVMTLRKQRASM
. .....| . |..|  |||||.|   ..||..........     ... |.|||||||||||||..|.  ..        ......  | ..|..|  .
ydpellerlgiqylylpwpDhgvp.llellleflefidell...alspggpvlVHCsaGvgRtgtlvaaylml........lglsleeavalvrekRpga

VQTQDQFQFVH
||...| .|..
vqnpsqyrfly
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 106-371 9.4e-39 128.0 In-house 11-262 (267) alignment 
Range on Protein: 106-371
Range on HMM: 11-262/267.0
EQEKLRMEAEYRSE--CAVAPQHYARNRYRDILPYDKNRVEIQKDSENpegYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLV
| |...  .. .|   . .| .  .|||. | ||||..|| ...  |.   |.||| ..    |  ||. | ||  |  .....| ...|. .|.| |  
efelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivlltkvf

eLNKIKceRYWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMENQTTgecRKVHQLHYREWPDHgcpSGEKQLLNmiDLMENIHEEVSPQDSSPIL
  ..|.  ..|| ..|... . |  .    ||  .| . .   ||..|...   ..|   .|..|      . .|  |.   |.  . ..   . . |..
.tdnir..lfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesa...hnvtlyyykkwnin...tnnkpylk..plfgilaknqlengnrPlv

VHCSAGVGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRH
|.||.||||.|| . |.   |..| |     ||| ... .|.|| ..|.|.... ..|. .| | .  
vacsdGvGrsGtflvidsqleraktegv..sdifdflrkirsqriglvdtkeryiyihellaeyaegr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 124-363 1.1e-38 127.8 In-house 31-290 (297) alignment 
Range on Protein: 124-363
Range on HMM: 31-290/297.0
PQHYARNRYRDILPYDKNRVEIQKDSENpEGYMNASLIQLPGGKT--EFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGES
.    .||||||| .|..|| ...   . . |.||  . .|  ..   .| || || ||.|..|... |. |  .|...|| |  . ||  |||. |.| 
nsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvqer

ELFGDYEITLEEEKLFDDDEYLMRCLKMENQttGECRKVHQLHYREWPDHGCPSGEKQL-----------------LNMIDL--------MENIHEEvSP
   ||. .    .   . |   .  |..  .   | |.|.   .  ||||| ||  ..|                 | ....        .| .. |  |
lkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslrae.mp

QdSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHsiDIFGLVMTLRKQRASMVQTQDQFQFVHRC
. . ..||||||||||.| ..  . | .... . .   |.  ..  ||.||| .||| .||....  
r.nayllvhcsaGvGrsGvvvlsdvilaklrkkrip..dvaailsilreqrarlvqtleqfellyda
0049260 (Phosphotyrosine protein) phosphatases II 166-361 4.7e-37 122.4 In-house 7-143 (152) alignment 
Range on Protein: 166-361
Range on HMM: 7-143/152.0
GKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWpeqvgeselfgdyeitleeeklfdddeylmrclkmenqttgecrkvhQLHY
 ..||||.|.|.| ||...|.|. |. .. .| |..|.||.|.|||.|.                                               | ..
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylh

REWPDHGCPSGEKQLLNMIDLMENIheevSPQDSSPILVHCSAGVGRTGTIIAINFIReqmkaetlHSIDIFGLVMTLRKQRASMVQTQDQFQFVH
  |||||.|. .  || .....| .      ... |.|||||||||||||..|.  ..        . ....  |  .|..|  .|....| .|..
lpwpDhgvpdlsqlllflllfiekl....aldkggpvlVHCsaGvgRtgtlvaaylml........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_ptpA1_pd Subfamily ptpA1 118-319 1.1e-36 121.5 In-house 37-249 (418) alignment 
Range on Protein: 118-319
Range on HMM: 37-249/418.0
SECAVAPQ--HYARNRYRDILPYDKNRVEIQKDSE-NPEGYMNASLIQLPGGKtEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYW
|| .   .    ..||| .||| .. ||...|  . .   |.||  |.    | .||..| ||| |. ..|.|. | |. ..|.| .  |  .|||.|||
setsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsresencrikcdryw

PEQVGE---------SELFGDYEITLEEEKLFDDDEYLMRCLKMenQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPQ--DSSPIL
|||.|           |.|| | . | |     . | . | ...     || | . | .|  ||||  |   . . ...  . | .... |      ||.
peqiggeqfsiygngnevfgtysvelveviqdpereiitrnirl..tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpii

VHCSAGVGRTGTIIAI
||||||||||||. . 
vhcsagvgrtgtfcta
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 129-368 3.2e-36 119.8 In-house 38-270 (285) alignment 
Range on Protein: 129-368
Range on HMM: 38-270/285.0
RNRYRDILPYDKNRVEIQKDSenpEGYMNASLIQLPGG-KTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDY
 ||| |.   .. || ...       |. || ...||  .. .|..| ||| || ..|.|| . ... |..|| |.|    ||  |.||..||   || |
lnryadvrcieetrvvlknhd...rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgky

EITLEEEKLFDDDEYLMRCLKMENQ--TTGECRKVHQLHYREWPDHGCPSGEKqllNMIDLMENIHeEVSPQDsSPILVHCSAGVGRTGTIIAINFIREQ
|||| | |       .. .| . |   .. |   . ...   |||. .|   .    ||.| . .. .| |..  || |||||||||| |.. |..   .
eitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedar...pmielykwvk.kvnpke.kpicvhcsagvgrtatfvgidyatir

MKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYC
.  .    |... .|  .|  |   ||.. || |..  .  | 
imen..pniemldivremramrfqavqshmqflflyvvlmeyf
0046846 (Phosphotyrosine protein) phosphatases II 155-366 4.1e-36 119.7 In-house 14-171 (176) alignment 
Range on Protein: 155-366
Range on HMM: 14-171/176.0
YMNASLIQLPggktEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESElfgdyeitleeeklfdddeylmrclkmenqtt
| ||.||  .     .|| |.||| || ....|. |.....|| |...|||...|| .||||  ...                                 
yinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi................................

gecrkvhQLHYREWPDHGCPSGeKQLLNMIDLMENIHEEvspqDsSPILVHCSAGVGRTGTIIAINFIREQmkaetlHSIDIFGLVMTLRKQRA-SMVQT
       | ..  |||||.|.  ..||........  .|    .  |.|||||||.|||||..|.  .. .      . ....  . ..|.||   .|||
.......qylhlpwpDhgvpdl.elllellefirealke....g.gpvlVHCsaGigRtgtlvaayllele......kglsveealalvreqRplgavqt

QDQFQFVHRCIAS
..| .|.....  
peQyrflyefell
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 127-360 1.8e-35 117.2 In-house 51-273 (301) alignment 
Range on Protein: 127-360
Range on HMM: 51-273/301.0
YARNRYRDILPYDKNRVEIQKDSENPEgyMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGD
  ..||  .    .  ||. .| .     . |  |. .|    |||.|.||..| ...| |.  . |  .|.|.. || .. ||| | | ...|.   | 
kdkhryptvPckPstavevivdGkrvP..ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

YEITLEEEKLFDDDEYLMRCLKMENQTTG-ECRKVHQLHYREWPDHGCPSGEKQllnMIDLMENIHEevspqDSSPILVHCSAGVGRTGTIIAINFIREQ
..|......|  ...   | |..|. |   . | |    | ||.|.| | .  .   . |||| . .        ||.||||||.||. . |. ...  .
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshae...lfdlmelvkk.....sekPivvhcsaGiGrsvafigteylare

MKAETlhSIDIFGLVMTLRKQRASMVQTQDQFQFV
..|.    |..   .  ||..| . |||. |. ..
veadp..tieltealkhlrehrwngvqtnsqlywm
0049772 (Phosphotyrosine protein) phosphatases II 111-373 2.1e-34 115.1 In-house 31-285 (314) alignment 
Range on Protein: 111-373
Range on HMM: 31-285/314.0
RMEAEYRSECAVAPQHYARNRYRDILPYDkNRVEIQKDSENPEGYMNASLIQLPggkTEFIAAQAPLPATLDEW----------WKMI--DEHRVSLVVI
..  |.    |  . .  .||| ||||.| ||| ... . .  .| ||| .  .     |||.|.||. |..            |.|.  ....|  .|.
svlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivm

---------------------LCKLVELNKIKCERYWPEQVgeselfgdyeitleeEKLFDDDEYlmrclkmenqttgeCRKVHQLHYREWPDHGCPsGE
                     |..| ... . .......                 | |.|.. .               | . ....  .||...|  .
srdevladelsrLdaAlgKtpllildgngneptaadlellk...............eelydpelf..............erlgikylripvpDgsap.ll

KQLLNMIDLMENIheevspQDSSPILVHCSAGVGRTGTIIAINFIREQMKaetlhsIDIFGLVMTLRKQRA-----SMVQTQDQFQFVHRCIASYCRRHL
.... .....|.       .. .|.||||.||.||||| ... ..  ...      ...   .  .|..|      .......|..|.....  |... .
edfdeflefieea......dkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

G
.
k
PTPc_DSPc_SM00012 259-365 1.3e-33 110.7 In-house 1-104 (105) alignment 
Range on Protein: 259-365
Range on HMM: 1-104/105.0
KVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEVSPqdSSPILVHCSAGVGRTGTIIAINFIREQMKAETlHSIDIFGLVMTLRKQRASMVQTQDQFQ
.|...|| .|||||.|.  . .|.... ... ... .   |.|..||||||||||||..|.  . .|...|| ...||| .|  |||||..||||..|..
tvkhyhytgwpdhgvPeesdsilellravkknknkses..skpvvVhCsaGvgRtgtfvaldillqqleket.kevdifqivkelrkqRpgmvqteeqyl

FVHRCIA
|..|...
flyrall
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 175-365 2.7e-32 106.4 In-house 98-285 (302) alignment 
Range on Protein: 175-365
Range on HMM: 98-285/302.0
APLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLE-----EEKLFDDDEYLMRCLKMENQTTGE--CRKVHQLHYRE
 |   ||. .| .|....|..|| ||..|| .. ||  |. ..||.   || | ..        |.. |  .. .  ....|. . .   . |. |..  
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGCPSGEKQLLNMIDLMENIHEEVspqdsspiLVHCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIA
||||| |   .. |...   |   ..|        |||||||||||||..|| .  .  . .  .  |.  .|. .|. |   ||...|  ..  |..
wpdhGapkeaytaldilkfcesykknv........lvhcsaGvGrtGtlvaikyGiqlcskk..kvtdllsivlpvrqcryGavqdeqqliylllcvt
0044763 (Phosphotyrosine protein) phosphatases II 137-364 1.1e-30 102.0 In-house 1-167 (178) alignment 
Range on Protein: 137-364
Range on HMM: 1-167/178.0
PYDKNRVEIQKDSENPEG-YMNASLIQlPGgkteFIAAQAPLpatlDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGeselfgdyeitleeek
|.| .|| ... .  . . |.||| |  ||    ......|      ...... |. ....| |.. .||...|| .||||. |                
pldrtrvllsnleglersdyinaseil.pg....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

lfdddeylmrclkmenqttgecrkvHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspQDSSPILVHCSAGVGRTGTIIAINFIREQmkaetlhSID
                          | ..  .||||.|.  ...|......|....    .. .|.||||||||||.||..|.  ....       ...
.........................iqylhipipDhgvpdllehflefvefieeald....ekggpvlVHCsaGvgRsgtlvaaylmkkl.......gls

IFGLVMTLRKQRAsMVQTQDQFQFVHRCI
..  .  .|..|  .|....| ...... 
leeaielvrerRp.ivpnpgqlrqLyefe
0051082 (Phosphotyrosine protein) phosphatases II 153-364 1.9e-30 100.8 In-house 3-149 (151) alignment 
Range on Protein: 153-364
Range on HMM: 3-149/151.0
EGYMNASLIQlPGgkteFIAAQAPLPatldEWWKMIDEHRVSLVVILCKLVELNkiKCERYWPEQVgeselfgdyeitleeeklfdddeylmrclkmenq
..| |.| .  .|    ... ..||.    . .... |. .. .| |....| .  .| .|.||.                                   
sdyinfsyvt.gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

ttgecRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENiheevspQDSSPILVHCSAGVGRTGTIIAINFIReQMkaetlhsIDIFGLVMTLRKQRASMVQ
     ..|.....  |||.|.|   ...|....|...       ... |.|||||||.|||||..|.  .  ..       ....  .  .|..|  .||
.....ievlhipildwpdpglplsfdavleflellld.......kkngpvlvHCsaGkgRTGtlvalylml.lg.......vsleealeeyrlkrpgvvq

TQDQFQFVHRCI
. .||.|.....
pnqqflfqlfal
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 124-373 7.3e-29 95.3 In-house 35-274 (281) alignment 
Range on Protein: 124-373
Range on HMM: 35-274/281.0
PQHYARNRYRDILPYDKNRVEIQK--DSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGES
|    .||| .|   |  ||...     .|   |. |  |. |  |  .| .| |   |  ..|.|| .   . .|.||...| |. ||  |.| .    
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahcc

ELFGDYEITLEEEKLfdDDEyLMrCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNmidLMENIHEevspqDSSPILVHCSAGVGRTGTIIAINF
  |  . .. |.  .  .   |.   ...    || | . .  ..||||   |   . .|.   .. .|.       |.| ..||||||||.||..|.. 
lqfdklsvsyedstv..nks.lv.ttrlnlsyegetrlithwlwkewpdwqvpessevmlk...ilrkira.....rstppvihcsagvgrsgtlmavei

IREQMKAEtLHSIDIFGLVMTLRK-QRASMVQTQDQFQFVHRCIASYCRRHLG
  . ...  .   ||  .|  ||   ||. ||| .|. .. . .  .   .  
alqsihsh.ftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvaykq
0048076 (Phosphotyrosine protein) phosphatases II 212-365 1.2e-27 91.7 In-house 1-140 (145) alignment 
Range on Protein: 212-365
Range on HMM: 1-140/145.0
RYWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLkmENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvspqdSSPILVHCSAGVG
.||| .. ..  .|..  .|. | | | . ..  .|   . .... |.. |..|  |||||.|.  ..||......|....|       |.|||||||||
pywpseilpglylgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealke.....ggpvlVHCsaGvg

RTGTIIAINFIREqmkaetlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIA
||||..|.  ...       ......  .  .|.||  .|....|..|..... 
Rtgtlvaaylmll.......lgvsleealelvrsqrpgavpnpgqlrflyefel
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 118-367 2.7e-27 90.3 In-house 35-275 (312) alignment 
Range on Protein: 118-367
Range on HMM: 35-275/312.0
SECAVAPQHYARNRYRDILPYDKNRVEIQKDsENpeGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQ
|||.   .    ||| .|  .|. |  .  | ||   |. | ....      |...|.||  |   .|..      . ...|| .||    || .|  . 
sectaflkfkdlnrypniqcwdrgrftlagd.en..fyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdi

VGESELFgDYEITLE-----EEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDlmeNIHeevspQDSSPILVHCSAGVGR
||  .|  |. .  |     |      |    | ||.  ..||.  |. .  .  ||||| |      | ..     ..     .|  |.. ||||||||
vgfvdle.dhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls...avk.....kdkkpviahcsagvgr

TGTIIAINFIREQMKAETLHS-IDIFGLvmtLRKQRASMVQTQDQFQFVHRCIASY
|||.. |. .   ..        |.| |   |||.||  |..  |. .. ||.  .
tgtlaliesmiaalrhprkqnvkdsfvl...lrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 125-370 7.8e-27 88.6 In-house 51-292 (310) alignment 
Range on Protein: 125-370
Range on HMM: 51-292/310.0
QHYARNRYRDILPYDKNRVEIQKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEqVGESELF
..  .||| |..  |. || .. |    | |. |  ..    .. || .| ||  |. ..|.|| . |   ...||| .|  . ||  |||  .| .| .
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywps.lgvtety

GDYEITLEEEK--LFDDD----EYLMRCLKMENQTT-GECRKVHQLHYREWPDHGCPSgEKQLLNMIDLMENIHEevspqdsSPILVHCSAGVGRTGTII
|   .|   |    |.       ..   . ...| .  .  .|  ... .||| | |  ||       |. ..          | .||||||..|.....
gcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpd.ekchtvpqrllaqvrh.......gpcvvhcsagkdrlyvvv

AINFIREqmKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRR
|...  .  |..  . .|.  ..  |.|.||  .||. |. ...|    ..| 
alklkid..kldrglkvdaeevktellksraiciqtelqyliidrvriifarg
0048179 (Phosphotyrosine protein) phosphatases II 213-362 1e-25 85.5 In-house 2-139 (144) alignment 
Range on Protein: 213-362
Range on HMM: 2-139/144.0
YWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMENQTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEevspqDSSPILVHCSAGVGR
..| .. ..  .|..  .|. | | . . ..  .|  |   . . | ..|...  |||||.|.  ..||......|...|     .. |.||||||||||
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.....eggpvlVHCsaGvgR

TGTIIAINFIReqmkaetLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHR
|||..|.  ..       .. ....  .  .|..|  .|....|..|...
tgtlvaaylmk.......klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 109-372 3.5e-24 79.7 In-house 34-289 (302) alignment 
Range on Protein: 109-372
Range on HMM: 34-289/302.0
KLRME-AEYRSeCAVAPQHYARNRYRDILPYDKNRVeiqKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATL---DEWWKMIDEHRVSLVVILCKLVE
|.    ..  . | .  .. ..|.  |.  .|.|.|   | ...|. |.||| ...|  . . | || |   .    .|.|.|. ....  |||| .  |
kidtmkvdlek.Ckafkknlkknqsedvpildsnlv...kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeee

LNKiKCERYWPEQVGESELFGDYEITLEEEKLFDDDEyLMRCLKMENQTTGECRKVHQLHYREWPDHGCPsgeKQLLNMIDLMENIHEEVSPQDSSpILV
|.|   . ..|.. |. . .|.  .     .  ....  . .. .  .   .   .   .   |...  |   ..  ..|  ....... .. |.. ...
lkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvp...vkyaeliktaakvfakkikaden.tvi

HCSAGVGRTGTIIAINFIREQMKAEtlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCRRHL
    |.|| |....     |.....  .   |  .|...|.||...|.. .|. ....... | ....
vSknGaGRagafltlavaveklqkg..kepnikeivksiRsqRpravdslkQyvslyialllyikkkv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 125-217 4.6e-24 79.8 In-house 46-153 (350) alignment 
Range on Protein: 125-217
Range on HMM: 46-153/350.0
QHYARNRYRDILPYDKNRVEIQ---------KDSENPEGYMNASLIQLP----GGKTEF--IAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIK
. .|.|||..||||...||...         | | ... |.||. ..|.      ...|  ||.||||| |.|...|.| .  | ... | ..||||  |
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CERYWPEQ
|.|||.| 
cyrYWqeg
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 152-365 1e-23 79.0 In-house 45-256 (290) alignment 
Range on Protein: 152-365
Range on HMM: 45-256/290.0
PEGYMNASLIQLPGGkTEFIAAQAPLPAT-------LDEWWKMIDEHRVSLVVILCKLVELNKI----KCERYWPEQVGESELFGDYEITLeeEKLFDDD
 ..|. |. .. | |  ..|. |.|. ..       . ..| |. . .|  || ||.  | ..      |..| ||.|||.  |.. ..     .   .|
nddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC..kskeked

EYLMRCLKMENQTTGECrKVHQLHYREWPDHGCPSGEKQLLNMIDlmeNIHeevspQDSSPILVHCSAGVGRTGTIIAINfIREQMKAETLHSIDIFGLV
.  .| | .. .   |  .|    ...| .   .  .| ||..|.   ...     .  .|..|||  |. |  .. ||. .  |. ||| .|. .  ..
dvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliq...kvk.....asktpvivHcvdGiSrsAalaaii.lgyQkiaetsgsvkledvl

MTLRKQRASMVQTQDQFQFVHRCIA
 .|||||| ..... .. ||   | 
kalrkqralaitsalelafvdagiv
subfamily_CG42327_pd Subfamily CG42327 121-284 1.7e-23 77.8 In-house 23-187 (319) alignment 
Range on Protein: 121-284
Range on HMM: 23-187/319.0
AVAPQHYARNRYRDILPYDKNRVEIQKDSENP-EGYMNASLIQLPG-GKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQV
.| .    ..|. ...|  . ||  |. .... . |..|| .. .   .. .||||..|  .  ..|... | .   .| |..| ||   .| .|.| . 
evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

G--ESELFGDYEITLEEEKLfdDDEYLMRCLKMENQTTGECRKVHQLHYrEWPDHGCPSGEKQLLNMI
.  . .|.||. .|| . .   .|.|..  | . .    |.|..    | .|.. . |. |. |. |.
tldntslyGdilvtlkgrev..kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 229-365 5.8e-23 75.9 In-house 64-191 (440) alignment 
Range on Protein: 229-365
Range on HMM: 64-191/440.0
ITLEEEKLFDDDEYLMRCLkMenqTTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvspQDSSPILVHCSAGVGRTGTIIAINFIREQMKa
. ||| |   |..|.     .   .  |.| ..| ||. |||.| |     .|.||. ... .|.     ..|.|||||||.|||| |||.. |  . | 
vmleevkgvpdsdyinasy.i...ngiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqek...agngpllvhcsagagrtgviiavdsilreak.

eTLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIA
     |||| .. ..|..|  |||| .|. ||| .. 
.rsdqidifsfinsmrnnrpqmvqtpeqyafvheavl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 256-369 3.1e-21 70.5 In-house 213-345 (350) alignment 
Range on Protein: 256-369
Range on HMM: 213-345/350.0
ECRKVHQLHYREWPDHGCPSGEKQLLNMID----LME--NIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIRE---QMKAET--LHSI--------DI
.   |.||... |.| .     ...|....    |..  . .. .  . |||||||||||||||||....... .    ..  |   . .         |
dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDli

FGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
. .|  ||||| ||||. ||| |.. ..  | .
siivnelrkqrismvqnldqfifiYeallfyfa
subfamily_egg_pd Subfamily egg 154-381 4.2e-21 69.9 In-house 69-283 (307) alignment 
Range on Protein: 154-381
Range on HMM: 69-283/307.0
GYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNkiKCERYWPEQVGESELFGDYEITLEEEKLFDDDEYLMRCLKMENqT
 .. |  ..      ||| |||||  | |..|.|. . .|  .|.|   .| .  .|| |||    .|  .    . .|  |. .  . |.|  |.    
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkese..rceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.v

TGEcrkVHQLHYREWP-DHGCPSGEKQLLNMIDLMEniheevspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDIFGLVMTLRKQRASMVQ
 |.     ...   |  |    |     |... ..         . | |..|..  || ...|..||.    ..    .    .   |. ||..|   |.
Ggd...deerflehwqgdvnnssdvysplrvlrklr........nlskpvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsve

TQDQFQFVHRCIASYCRRHLGIIEEPKLD
.  .. ||.| .. . |  .|  .|  .|
svllylfvyrlvlfffrdvigsakeldvd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 172-359 2.6e-20 67.6 In-house 39-212 (255) alignment 
Range on Protein: 172-359
Range on HMM: 39-212/255.0
AaqaplpaTLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEeklfDDDEYLMRCLKMENQTT--GECRKVHQLHYREWP
        |.|.....|   . . ||.|| . | .. ||..|.| .  |   . | ..|  .       . ..| |..  . .   . ..|.  .|. |.
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk....ssadvvlrtleitstlgekkkthtvkhysykGWi

DHGCPSGEKQLLNMIDLMeniheevspQDSSPILVHCSAGVGRTGTIIAINFIRE----QMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQF
..  |   ...||.. ..         .|| ...||||.|.||. . . ....      ...      .|   |.  ||..|.. ..|  |. |
eknaPelareilnilkvv.........rdsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 128-367 2e-18 61.1 In-house 49-278 (303) alignment 
Range on Protein: 128-367
Range on HMM: 49-278/303.0
ARNRYRDILPYDKNRVEIQKDSenpegYMNASLIQLPGGKTeFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVgESELFGDY
 .||. |..  |. .|..   |     |. || ..|   |   | .| ||. |  ..|.|| | .|  |..|    | .|.  .  .|..  .   | . 
dknrfvdvicldhskvklsdss.....yihasyleldsskk.ailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq.dflkfeer

EITLEEEKLFD-DDEYLMRCLKMENQTTGECrkVHQLHYREWPDHGCPSG-EKQLLNMIDLMENIHEEVSpqDSSPILVHCSAGVGRTGTIIAINFIREQ
 | . | |  .  | . .. | . | .      .|  ||..||    ||    .... |  .. .    |  ||.| .    .|.||.||.  ..     
sirvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsdgspkfvkqiwqlqsvlrkys..dstptvymslsgcgragtfalfetahls

MKAETlHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASY
...|   |.|.   . ..|. |   ||   || .|.  .| .
lhseq.asldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_CG42327_pd Subfamily CG42327 298-369 5.9e-18 59.6 In-house 246-316 (319) alignment 
Range on Protein: 298-369
Range on HMM: 246-316/319.0
DSSPILVHCSAGVGRTGTIIAINFIREQMkAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
.  |. |||| ||||||..|| ..  ...  |. .|.||  ||  .|..||| |.|..|..|... .  |..
sqGPlvvhcsdGvGrtGlviasdiairsl.eeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 253-369 2.4e-17 57.3 In-house 213-345 (349) alignment 
Range on Protein: 253-369
Range on HMM: 213-345/349.0
TTGECRKVHQLHYREWPDHGCPSGEKQLLNMIDLMENIHEE------VSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLH----------SIDI
.. .  .. || ...|.| .     . .|. ..  ... ..      .  ...|..||||||| ||||... .... . ..  . .             |
avekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDli

FGLVMTLRKQRASMVQTQDQFQFVHRCIASYCR
.  | .||||| ||||   || ... ..  |..
siivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_hpo-7_pd Subfamily hpo-7 177-359 4.4e-17 56.9 In-house 43-218 (263) alignment 
Range on Protein: 177-359
Range on HMM: 43-218/263.0
LPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEEEKLfdddEYLMRCLKMENQTT--GECRKVHQLHYREWPDHGCP
|  |.|. ...|   . . ||.||   | .. ||..|.| .  |   . . ...  . .     . |.. |.. ..     . ..|..  |. |...  |
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs....dvllktlellstlgeKkkthtvkhysykgWiekndp

SGEKQLLNMIDLMeniheevspQDSSPILVHCSAGVGRTGTIIAINFIRE----QMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQF
   .. ||....          ..| .. ||||.|.||.     ....      ...      .|   |.  ||..|.. ..|  |. |
elareilnilkva.........rnskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf
subfamily_eak_pd Subfamily eak 128-287 1.1e-16 55.2 In-house 54-207 (332) alignment 
Range on Protein: 128-287
Range on HMM: 54-207/332.0
ARNrYRDILPYDKNRVEIQKDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDY
 ||   .|.|||.. |..     |..||.||||....    ..| . ..    .  .|.|. | .   .| | . |||.  | ..|.|..  |   || .
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

EITLEEEklFDDDEYLMRCLKMenQTTGECRKVHQLHYREWPDHGCPSGEkQLLNMIDLM
...  |      . . .| |..  .   |  .|.  ..  | .   |  | ..| . . |
dverkef..vkrniletrllel..skGnethrvlhykvfGwtettlpkye.dflalrkvm
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 125-216 1.2e-15 51.8 In-house 47-155 (349) alignment 
Range on Protein: 125-216
Range on HMM: 47-155/349.0
QHYARNRYRDILPYDKNRVEIQKD---------------SENPEGYMNASLIQLPGGK--TEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNK
. .|.|||.|||||.  || ..|                |  .. |.||  ..|.  .    .|| |||||.|.|...|.|   .| ||. | .  ||. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

IKCERYWPE
 ||..|| |
ekcdiywqe
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 95-232 5.3e-14 46.4 In-house 67-196 (244) alignment 
Range on Protein: 95-232
Range on HMM: 67-196/244.0
DYLRRFYqIRVEQEKLRMEAEYRsECAVAPQHYARNRYRDILPYDKNRVEIQKDSENpEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVS
||.   | |.  |. .| .     . |. |.   .||    ||.| ||| . | |   . |.|||..   |  .|.| .| ||  |  ..|||. |  | 
dyinany.iqgsqniirpdpsvm.kdafnpnnswknregaglpfdfnrvplskgsmg.ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvn

LVVILCKLVELnkikcERYWPEQVGESELFGDYEITLE
..|.|  . |      . |||.         |  .|| 
vlvvlgsveee.....deywpdseplewyeeditvtlt
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 166-361 6.6e-14 46.5 In-house 3-197 (199) alignment 
Range on Protein: 166-361
Range on HMM: 3-197/199.0
GKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEeeKLFDDDEYLMRCLKMENQTTG--ECRKVHQL
|.  .||.| ||  |. ..|.|. |     .|..      ..     |||     .  .|   .| .   .    .| . .| . |.||     |.. . 
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk..tittkpdytitaliltnnttappstreishy

HYREWPDHGCPSGEkQLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVH
 .  | ..  |     .. ..    ..      .  .|..|||| | | || ..|..      .      .|.| .   ||. |  .. . ....|..
qftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 166-361 6.7e-14 46.5 In-house 2-196 (198) alignment 
Range on Protein: 166-361
Range on HMM: 2-196/198.0
GKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELNKIKCERYWPEQVGESELFGDYEITLEeeKLFDDDEYLMRCLKMENQTTG--ECRKVHQL
|.  .||.| ||  || ..|.|. |     .|..      ..     |||     .  .|   .| .   .    .| . .| . |.||     |.. . 
gqrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttk..tittkpdytitaliltnnttappstreishy

HYREWPDHGCPSGEkQLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDIFGLVMTLRKQRASMVQTQDQFQFVH
 .  | ..  |     .. ..    ..      .  .|..|||| | | || ..|..      .      .|.| .   ||. |  .. . ....|..
qftswkekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 304-365 1.1e-12 42.1 In-house 2-61 (69) alignment 
Range on Protein: 304-365
Range on HMM: 2-61/69.0
VHCSAGVGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCIA
||||.| ||||| |||     ..|.| |  .|||  |  .|| |  ||  .... |.|  ..
vhcssGtGrtGtfiaimvemariksekl..vdifnnvqymrkcrpmmvmneneymfihdalv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 303-364 2.1e-12 41.2 In-house 2-61 (69) alignment 
Range on Protein: 303-364
Range on HMM: 2-61/69.0
LVHCSAGVGRTGTIIAINFIREQMKAETLhsIDIFGLVMTLRKQRASMVQTQDQFQFVHRCI
.||||.| |||||.|||     ..|.| |  .|||  |  .|| |  ||  . .. |.|  .
vvhcssgtgrtgtfiaimvemariksekl..vdifnnvqymrkcrpmmvmneieyifihdal
0038934 (Phosphotyrosine protein) phosphatases II 262-363 1.5e-11 39.8 In-house 81-172 (194) alignment 
Range on Protein: 262-363
Range on HMM: 81-172/194.0
QLHYREWPDHGCPSGEKQLLNMIDLMENIHEEvspQDSSPILVHCSAGVGRTGTIIAINFIR-EQMKAETlhsidifgLVMTLRKQRASMVQTQDQFQFV
. .   .||.|..   ..||. .||.. ...|   . .  ..||| ||.|||||..|   |   .|.||          . ..|  | .....||... .
eylklpfpddgtvPsleillrfldlvdeflne...dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaee........AialfrekRpgaipnqdyleal

HRC
.. 
lkr
subfamily_PTPDC1_pd Subfamily PTPDC1 265-362 3.8e-11 37.7 In-house 87-170 (182) alignment 
Range on Protein: 265-362
Range on HMM: 87-170/182.0
YREWPDHGCPSGEkQLLNMIDLMENIHEEvspQdssPILVHCSAGVGRTGTIIAINFIREQ-MKAEtlHSidifglVMTLRKQRASMVQTQDQFQFVHR
   |.|.| .| | ..|... ...   .|   .    . ||| || |||| .||  ..  . ..||  ..      . ..|..|.. .||..| ..|. 
nfgwkDygvasle.riLdivkvvafalqe...g...kvavhChaGlGrtGvliacylvyakrltae..ka......iklvrskrpksiqtreqvelvke
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 147-200 8.2e-10 32.7 In-house 64-117 (347) alignment 
Range on Protein: 147-200
Range on HMM: 64-117/347.0
KDSENPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILC
  ....|.|.||| |..   ..|.| .| ||| |. ..|||.   .|. || . 
sraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 136-229 3e-09 31.3 In-house 3-82 (130) alignment 
Range on Protein: 136-229
Range on HMM: 3-82/130.0
LPYDKNRVEiqkdsenPEGYMNASLIQLPGGKTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKLVELnkikcERYWPEqvgeSELFGDYE--I
|... .|..        . |.|||.. | |  .|.. .|.|| .|  ..|||. |  | ..|.|  . |      . |||.    || .  ||  |
lefevsrlq.......gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd....sePlewyeedi
subfamily_PTEN_pd Subfamily PTEN 237-360 8.4e-09 30.7 In-house 73-172 (184) alignment 
Range on Protein: 237-360
Range on HMM: 73-172/184.0
FDDDEYLMRCLKMENQttgecrkvhqlhyrewpDHGCPSgekqLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDI
.| ...  |  ... .                 ||  |.    |  . ...|.|.. .. ...  . ||| || ||||..|.  .. ...  .. .....
ydskkfdgrvavypfd.................Dhnppp....lelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealel

FglvMTLRKQRASMVQTQDQFQFV
|   .. | . .. |.   |  .|
f...aeaRtknkkgvtiPsqrRYv
PTEN_1 264-325 1.5e-08 29.7 In-house 98-156 (196) alignment 
Range on Protein: 264-325
Range on HMM: 98-156/196.0
HYREWPDHGCPSgekqLLNMIDLMENIHEEVSPQD-SSPILVHCSAGVGRTGTIIAINFIREQ
. ....||| ||    |  ..|  ....| .. ..    .|||| ||.||.||..|   .. .
lhfpieDhgaps....lselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykg
subfamily_VSP_pd Subfamily VSP 279-361 3.1e-08 27.8 In-house 108-192 (212) alignment 
Range on Protein: 279-361
Range on HMM: 108-192/212.0
QLLNMIDLMENIHEEVSPQDSSPILVHCSAGVGRTGTIIAINFIREQMKAETLHSIDIFGLVMTLRKQR--ASMVQTQDQFQFVH
.| ... . ....| .. . .  . .||  | ||||||.   ..  ..  .. .|.| ||   | ...      |||  | ..|.
kleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvg
subfamily_DSP23_pd Subfamily DSP23 269-362 3.3e-08 28.3 In-house 60-140 (148) alignment 
Range on Protein: 269-362
Range on HMM: 60-140/148.0
PDHgCPSGEKQLLNMIDLMENIHEEvspqdSSPILVHCSAGVGRTGTIIAINFIREQMKAETlhsiDIfglVMTLRKQRASMVQTQDQFQFVHR
.|. .|   .|. ... ..|. .|      .  . |||  | |||||..|  ...|.  | .    .    .  .|..|   |.| .| . |. 
ddy.hppaleqvvefvrvveeaeek.....neavsvhcllgrgrtgtmlacylvkerklaaa....ea...iaevrrlrpgsvetveqeklvrd
DSPc Dual specificity phosphatase, catalytic domain 266-358 7.7e-08 27.3 Pfam-A 38-124 (133) alignment 
Range on Protein: 266-358
Range on HMM: 38-124/133.0
REWPDHGCPSGEKQLLNMIDLMENIHE---EVsPQDSSPILVHCSAGVGRTGTIIaINFIREQMKAETLHSIDIFglvmtlrKQRASMVQTQDQFQ
 |  . ..|  ...  .. . .|.. |   ..  |.   .|||| ||. |..|.| | .. .... .. . ....       |.|.|..  ...|.
seieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatli.iaYlmktknlslneAyefv.......kerrskispnagfl
DSPc Dual specificity phosphatase, catalytic domain 266-358 7.7e-08 27.3 In-house 38-124 (133) alignment 
Range on Protein: 266-358
Range on HMM: 38-124/133.0
REWPDHGCPSGEKQLLNMIDLMENIHE---EVsPQDSSPILVHCSAGVGRTGTIIaINFIREQMKAETLHSIDIFglvmtlrKQRASMVQTQDQFQ
 |  . ..|  ...  .. . .|.. |   ..  |.   .|||| ||. |..|.| | .. .... .. . ....       |.|.|..  ...|.
seieylripvedetetkiskeleeavefieka.eqkgkkvlVHCqaGisRSatli.iaYlmktknlslneAyefv.......kerrskispnagfl
PTPc_motif_SM00404 276-357 1.4e-07 26.5 In-house 62-130 (140) alignment 
Range on Protein: 276-357
Range on HMM: 62-130/140.0
GEKQLLNMIDLMENIheevsPQDSSPILVHCSAGVGRTGTIIainfIREQMKAETLHSIDIFGLVmtlRKQRaSMVQTQDQF
  |.| ...| .||.      ..   .|||| ||| |..|.|    | . |. . |   . . .|   ...| .... . .|
lskyldkvldfiena.....ekkggkvlVHCqaGvSRSatli....iaYlmryrqlslaeayefv...kerR.piispnlnf
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 167-227 4e-07 23.7 In-house 235-291 (440) alignment 
Range on Protein: 167-227
Range on HMM: 235-291/440.0
KTEFIAAQAPLPATLDEWWKMIDEHRVSLVVILCKlveLNKIKCERYWPEQVgESELFGDY
|  |||.| || .|. ..|... ..|.| ...| .   ||   |  ||| .   |  || .
knafiatqmpldstvldfwrlvhdyristiimlnq...lndktcsiywpvnt.rsvtfgpf
subfamily_CDC14_pd Subfamily CDC14 299-354 2e-06 21.9 In-house 263-320 (328) alignment 
Range on Protein: 299-354
Range on HMM: 263-320/328.0
SSPILVHCSAGVGRTGTIIAINFIREQ--MKAETLHSIDIFGLVMTLRKQRASMVQTQ
.  | ||| ||.|||||.||  ....     ||..  . |    . . .|.  ... |
eGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfleekq
subfamily_PRL_pd Subfamily PRL 272-330 2.8e-06 21.5 In-house 66-121 (151) alignment 
Range on Protein: 272-330
Range on HMM: 66-121/151.0
GCPSGEKQLLNMIDLMENIHEEvspQDSSPILVHCSAGVGRTGTIIAINFIREQMKAET
| .  |. . . ..|... ..|   . .| . ||| ||.||.  ..|. .| . || | 
GavPpeevveeWlellkekfke...epkstvavhcvaGlGraPvlvalalieaGmkyed
subfamily_CDKN3_pd Subfamily CDKN3 265-362 7.7e-06 19.6 In-house 104-190 (202) alignment 
Range on Protein: 265-362
Range on HMM: 104-190/202.0
YREWPDHGCPSgekqLLNMIDLMENIHEEVspQDSSPILVHCSAGVGRTGTIIAINFIreqMKAETLHSIDIFGLVMTLRKQRAsmVQTQDQFQFVHR
.   .| . |.      . ....|...  .  ..    ||||  |.||.  .||  ..   .  .|..  |    .  |.  ||  .||  |..... 
hypiadglvpd....iasclkileelrinl..kayrktlvhcygglgrsslviaclll...ylddtiepkdaidklrdlkgsra..iqtvkqynylse